Academic literature on the topic 'Intervalle libre'
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Journal articles on the topic "Intervalle libre"
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Bonin, B., and B. Trojak. "Intervalle libre et/ou rémission." L'Encéphale 35 (October 2009): S172—S177. http://dx.doi.org/10.1016/s0013-7006(09)72524-2.
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Sportiche, S. "Quel est le profil clinique des patients avec trouble bipolaire répondeur au lithium ?" European Psychiatry 28, S2 (2013): 96–97. http://dx.doi.org/10.1016/j.eurpsy.2013.09.258.
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Le lithium reste le « gold standard » du traitement prophylactique dans les troubles bipolaires. En moyenne, chez 80 % des patients bipolaires traités par lithium, celui-ci a un effet préventif à long terme permettant une réduction du nombre d’épisodes thymiques, avec une réponse complète dans 30 à 60 % des cas. Toutefois, 20 % des patients sont non répondeurs et chez 30 à 50 % des patients la réponse n’est que partielle [1]. Dans les études antérieures, certaines variables ont été identifiées comme de possibles facteurs prédictifs d’une bonne réponse prophylactique au lithium : une bonne réponse initiale au traitement en aigu, une séquence manie-dépression intervalle libre, des antécédents familiaux de troubles bipolaires répondeurs au lithium, une apparition tardive de la maladie. À l’inverse, une comorbidité psychiatrique comme les troubles addictifs ou de la personnalité, une séquence dépression-manie-intervalle libre et la présence de cycles rapides représenteraient de potentiels facteurs de risque d’une mauvaise réponse 2,3. Cependant, en raison de l’absence de consensus sur la définition de la réponse prophylactique au lithium, les données de la littérature sont parfois contradictoires. Ainsi, malgré les nombreuses études antérieures, il n’existe toujours aucun marqueur prédictif unanime de la réponse au lithium. L’objectif de cette étude est d’identifier les facteurs cliniques associés à la réponse prophylactique au lithium, évaluée par le questionnaire d’ALDA [4], dans une population de 227 patients traités par lithium pendant plusieurs années. Nos résultats montrent que le sous-type bipolaire de type I, une histoire d’épisodes mixtes ou saisonnier, la rémission incomplète après un épisode, les antécédents de traumatisme dans l’enfance et la comorbidité avec un trouble addictif sont associés à mauvaise réponse au lithium dans les troubles bipolaires. les patients présentant ces caractéristiques pourraient bénéficier d’un autre traitement prophylactique en monothérapie ; une association avec le lithium pourrait être discutée dans certains cas.
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Castadot, Pierre, Nicolas Magné, Martine Roelandts, Pauline Gastelblum, Nordeyn Oulad Ben Taib, and Paul Van Houtte. "Métastase d'un épendymome lombosacré avec très long intervalle libre : cas clinique et revue de la littérature." Cancer/Radiothérapie 10, no. 3 (2006): 148–51. http://dx.doi.org/10.1016/j.canrad.2006.02.003.
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Ziani, El Mostafa, Mustapha Bennouna, and Raymond Boissier. "Une technique ultrasonore pour la supervision des canaux d’irrigation ouverts." Revue des sciences de l'eau 20, no. 3 (2007): 287–97. http://dx.doi.org/10.7202/016503ar.
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Résumé Cet article présente un débitmètre à ultrasons conçu en tant que capteur intelligent pour la mesure des écoulements en surface libre ou en conduites fermées. Ce type de débitmètre peut être utilisé pour des applications industrielles ou de gestion de l’eau. Il répond à la forte demande des autorités de supervision des ressources en eau dans les régions semi-arides d’agriculture irriguée. Un état de l’art et les principes généraux des mesures de débits de liquide par ultrasons sont donnés. Le débitmètre original proposé utilise le principe de la mesure des délais entre les impulsions envoyées vers l’amont et vers l’aval dans le fluide. L’approche repose sur la mesure de la différence du temps de transit des ondes acoustiques sur une ou plusieurs cordes de mesure, réparties sur un intervalle suffisant, de manière à assurer la précision requise. Cette méthode permet une véritable intégration du profil des vitesses, ce qui assure une meilleure précision. La vitesse du son dans le fluide est éliminée des calculs grâce à l’utilisation des temps de transmission réciproques. Les calculs de débit sont assurés par un micro-contrôleur. Les calculs théoriques et les technologies proposées ont donné lieu à la réalisation d’un prototype expérimental. Une première application de ce débitmètre à ultrason est réalisée en laboratoire en conduite fermée dans une installation d’essai comportant une seule paire de transducteurs à ultrason. Une seconde application expérimentale est menée sur un banc d’essai comprenant un canal artificiel de forme trapézoïdale de dimensions géométriques bien déterminées avec une pente variable. Ces tests ont permis de vérifier la précision de l’appareil et de valider les techniques et les principes mis en oeuvre dans la conception du débitmètre.
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Bylicki, O., C. Segura, C. Chouaid, et al. "Efficacité du pemetrexed en 2e ligne dans les CBNPC avancé après un intervalle libre ou un traitement de maintenance par gemcitabine ou erlotinib dans l’étude IFCT-GFPC 05-02." Revue des Maladies Respiratoires 30 (January 2013): A16. http://dx.doi.org/10.1016/j.rmr.2012.10.056.
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Dionisio, Guilherme, and Wictor C. Magno. "Photogate de baixo custo com a porta de jogos do PC." Revista Brasileira de Ensino de Física 29, no. 2 (2007): 287–93. http://dx.doi.org/10.1590/s0102-47442007000200014.
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Apresentamos neste trabalho um dispositivo de baixo custo para medidas de intervalos de tempo, velocidades e acelerações, bastante útil no problema de queda livre e em outros experimentos de mecânica. Construímos uma photogate usando a porta de jogos do PC para fazer aquisição de dados e para obter a aceleração da gravidade. Obtemos boa concordância dos dados experimentais com um modelo teórico de um corpo em queda livre. Nosso trabalho ressalta uma forma de medir com precisão curtos intervalos de tempo, e abre novas possibilidades de aplicação ao ensino de física.
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Quirós Vásquez, Armando, Elizabeth Carpio-Rivera, and Walter Salazar-Rojas. "Efecto del calentamiento activo y de diferentes intervalos de recuperación sobre el rendimiento en natación." Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud 18, no. 1 (2020): e40846. http://dx.doi.org/10.15517/pensarmov.v18i1.40846.
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Propósito: Determinar el efecto del calentamiento activo con diferentes intervalos de recuperación en el rendimiento deportivo, en las pruebas de 50 y 200 metros libre. Metodología: Participaron 17 atletas (edad 13,5 ± 2,18 años), inscritos ante la Federación Costarricense de Deportes Acuáticos, con experiencia de entrenamiento y competición de 4,47 ± 1,28 años. Previo a la ejecución de las pruebas 50 y 200 metros libre, se realizaron 4 condiciones experimentales: Control (sin realizar calentamiento); Calentamiento (960 m) + descanso 20 min; Calentamiento (960 m) + descanso 10 min; Calentamiento (960 m) sin descanso. El orden de ejecución de las pruebas (50 y 200 metros libre) y la ejecución de las condiciones experimentales, fueron asignadas de forma aleatoria. El análisis estadístico se realizó mediante ANOVA de una vía de medidas repetidas, p <0,05. Resultados: No existió diferencia significativa en el rendimiento en una prueba de 50m libre (F=0,83, p= 0,48) ni en la prueba de 200m libre (F=0,88, p= 0,46), al realizar un calentamiento activo respecto a no realizarlo. No hubo influencia de los diferentes tiempos de recuperación en el rendimiento en ambas pruebas. Se observaron diferentes patrones de respuesta individual a las condiciones experimentales. Conclusión: De manera grupal, en nadadores jóvenes con poca experiencia, ejecutar un calentamiento activo previo a las pruebas de 50 y 200 metros libre, no mejora el rendimiento. Se recomienda que el entrenador ponga atención a la respuesta individualizada, para que elija el mejor protocolo (calentamiento o no) para mejorar el rendimiento deportivo de sus atletas.
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Saint-Jacques, Denis, and Alain Viala. "A propos du champ littéraire. Histoire, géographie, histoire littéraire." Annales. Histoire, Sciences Sociales 49, no. 2 (1994): 395–406. http://dx.doi.org/10.3406/ahess.1994.279266.
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Les quelques réflexions qui suivent sont faites à partir du livre de Pierre Bourdieu, Les Règles de l'art. Genèse et structure du champ littéraire. A partir de : en cela, elles répondent sans doute à l'un des voeux de l'ouvrage qui, dans ses énoncés volontiers programmatiques, tend à susciter des prolongements. A partir de et non pas sur : on ne traitera donc pas ici de son analyse de L'Éducation sentimentale et des débats qu'elle a, à juste titre, provoqués. Ni de ceux qu'a enclenchés le ton polémique exhibé par intervalles dans ce Livre.
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Wu, Jie. "Distribution des nombres $\mathcal {B}$-libres dans de petits intervalles." Journal de Théorie des Nombres de Bordeaux 5, no. 1 (1993): 151–63. http://dx.doi.org/10.5802/jtnb.85.
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Merino-Soto, César Ayax. "Intervalos de confianza para la diferencia entre coeficientes de validez de contenido (V Aiken): Una sintaxis SPSS." Anales de Psicología 34, no. 3 (2018): 587–90. http://dx.doi.org/10.6018/analesps.34.3.283481.
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El análisis el de la validez de contenido usualmente incluye medidas para cuantificar sumariamente las calificaciones de jueces expertos. Sin embargo, las diferencias entre grupos de jueces no han sido previamente planteadas, y es plausible que estas diferencias ocurran. El presente manuscrito plantea la comparación entre-grupos del coeficiente V Aiken, 1980), como una estrategia que debe ser implementada en el análisis de la validez de contenido. Se presenta un método basado en la construcción de intervalos de confianza para la diferencia entre coeficientes V, para dos grupos independientes. Finalmente, también se incluye un programa en sintaxis SPSS de libre distribución para su implementación.
Dissertations / Theses on the topic "Intervalle libre"
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TEISSEYRE, MONIQUE. "Le cancer intervallaire du sein." Montpellier 1, 1992. http://www.theses.fr/1992MON11220.
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Albernaz, Vinicius Gonzalez Peres. "Terapia citorredutora pré-operatória associada ou não à quimioterapia metronômica adjuvante com ciclofosfamida e piroxicam em cães com carcinoma de células escamosas cutâneo." Botucatu, 2019. http://hdl.handle.net/11449/180844.
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Orientador: Juliany Gomes QuitzanResumo: O carcinoma de células escamosas (CCE) é uma neoplasia epitelial originada dos queratinócitos da pele de cães. Sua etiologia está relacionada à exposição a raios solares ultravioletas, o que o coloca como uma das neoplasias mais frequentes em países tropicais de clima quente. O CCE cutâneo tem comportamento invasivo local, baixa capacidade de metástase e frequentemente encontra-se associado à ceratose actinica. Neste estudo, objetivou-se avaliar o efeito do tratamento pré-operatório com piroxicam (Px) na expressão de COX-2 e Ki67, indicadores de inflamação e proliferação celular, respectivamente, em cães acometidos por CCE cutâneo. Além disso, o intervalo livre de doença (ILD) por um período de pelo menos 180 dias após excisão cirúrgica associada a regime de baixa dose diária com Px (0.3mg/kg) e ciclofosfamida (CYC; 15mg/m2) foi determinado nesta população. Não houve diferença estatística significativa na expressão de COX-2 após o tratamento pré-cirúrgico com Px; no entanto, houve diminuição no índice proliferativo marcado com Ki67 (P<0.05). Não foi encontrada alteração significativa no ILD no grupo tratado com Px e CYC (160 dias), quando comparado com o grupo controle retrospectivo (145 dias), tratado somente com ressecção cirúrgica. Não houve diferença estatística no ILD quando analisados o grau histológico, índice mitótico, tempo de evolução, metástase de linfonodos e o comprometimento das margens cirúrgicas. Adicionalmente, cães com estadiamento T4, independente do tratam... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Squamous cell carcinoma (SCC) is an epithelial neoplasm that arises from skin keratinocytes of the dogs. Its etiology is related to ultraviolet sunlight, which puts it as one of the most frequent neoplasm in tropical hot weather countries. Cutaneous SCC have a locally invasive, low metastatic behavior, and is often associated with actinic keratosis. This study aimed to evaluate the effect of pre-operative treatment with piroxicam (Px) on COX-2 and Ki67 expression, indicators of inflammation and cell proliferation, respectively. Besides that, the evaluation of disease-free interval (DFI) of these animals for at least 180 days after surgical excision associated with a daily low-dose treatment with Px (0.3mg/kg) and cyclophosphamide (CYC; 15mg/m2). There was no statically significant difference between COX-2 expression before and after treatment with Px; However, there was a significant decrease on Ki67 proliferative index (P<0.05). No significance was found in DFI when comparing the group treated with Px and CYC (160 days) and the control retrospective group (145 days), treated only with surgical resection. There was no statically difference on DFI when accessing histological grade, mitotic index, evolution time, lymph node metastasis, and incomplete surgical margins (P>0.05). Additionally, dogs with T4 stage, independent of the treatment, were 3.2 and 4.8-fold more likely to develop an early recurrence when comparing with T3 and T2, respectively. The results of this study demo... (Complete abstract click electronic access below)
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Dinis, Rúben Miguel de Sousa. "Avaliação de fatores de prognóstico associados ao fibrossarcoma no gato : estudo retrospetivo." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/13139.
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Dissertação de Mestrado Integrado em Medicina VeterináriaOs fibrossarcomas são neoplasias mesenquimatosas que ocorrem sobretudo na pele e tecido subcutâneo, sendo comuns na espécie felina. A excisão cirúrgica agressiva com amplas margens é o tratamento de eleição que pode ser associado a radioterapia, quimioterapia ou imunoterapia adjuvantes ou neoadjuvantes. Devido às características invasivas destes tumores, o prognóstico é reservado em relação ao controlo local, no entanto mesmo perante múltiplas recidivas a sobrevivência tende a ser prolongada. Torna-se por isso imperativo avaliar variáveis que possam ajudar o clínico e o dono a prever o sucesso terapêutico ou o curso da doença, e determinar que tratamentos complementares possam beneficiar o animal. O presente estudo retrospetivo teve como objetivo a avaliação de fatores de prognóstico, em 38 casos clínicos submetidos a cirurgia associado ou não a tratamento quimioterápico. A idade mediana foi de 10,3 anos, não houve predisposição de género, os gatos eram maioritariamente de raça Europeu Comum e a localização anatómica mais frequente foi a interescapular (32,4%). A recidiva ocorreu em 31,6% dos casos e a metastização em 7,9%. A mediana do intervalo livre de doença não foi atingida e a mediana do tempo de sobrevida foi de 761 dias. Não foi identificada uma associação entre o intervalo livre de doença e as variáveis: idade no momento do diagnóstico, género, localização tumoral, avaliação pré-cirúrgica com tomografia computorizada, ocorrência de deiscência de sutura cirúrgica, realização de quimioterapia e estatuto das margens histológicas. O estadiamento clínico foi o único fator de prognóstico identificado com influência no intervalo livre de doença. Os casos com tumores de menores dimensões (menores ou iguais a 5 cm; T1 e T2) apresentaram intervalos livres de doença mais longos que casos com tumores de maiores dimensões (maiores que 5 cm; T3). Os resultados obtidos sugerem que o tamanho tumoral está associado ao intervalo livre de doença, no entanto, outros estudos, com amostras e acompanhamento maiores, são necessários para apoiar estes resultados.
ABSTRACT - EVALUATION OF PROGNOSTIC FACTORS ASSOCIATED WITH FIBROSSARCOMA IN CAT - RETROSPECTIVE STUDY - Fibrosarcomas are mesenchymal neoplasms occurring mainly in the skin and subcutaneous tissue, being common in the feline species. Aggressive surgical excision with wide margins is the treatment of choice that may be associated with adjuvant or neoadjuvant radiotherapy, chemotherapy or immunotherapy. Due to the invasive characteristics of these tumors, the prognosis is reserved in relation to the local control, however even in the case of multiple relapses the survival tends to be long. It is therefore imperative to evaluate variables that may help the clinician and the owner to predict the therapeutic success or course of the disease and determine which complementary treatments may benefit the animal. The present retrospective study had as objective the evaluation of prognostic factors, in 38 clinical cases submitted to surgery associated or not to chemotherapeutic treatment. The median age was 10.3 years, there was no gender predisposition, the cats were mostly of European Common breed and the most frequent anatomic location was the interscapular (32.4%). Recurrence occurred in 31.6% of cases and metastasis in 7.9%. The median disease free interval was not reached and the median survival time was 761 days. No association was identified between the disease free interval and the variables: age at diagnosis, gender, tumor location, pre-surgical evaluation with computed tomography, surgical suture dehiscence, use of chemotherapy and histological margins status. Clinical staging was the only prognostic factor identified with influence on the disease free interval. Cases with smaller tumors (less than or equal to 5 cm, T1 and T2) had longer disease-free intervals than cases with larger tumors (greater than 5 cm, T3). The results suggest that tumor size is associated with the disease free interval, however, other studies, with larger samples and follow-up, are necessary to back up these results.
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Dhouibi, Hedi. "Utilisation des réseaux de Petri à intervalles pour la régulation d'une qualité : application à une manufacture de tabac." Ecole Centrale de Lille, 2005. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2005/50376-2005-Dhouibi.pdf.
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La première partie de ce travail est consacrée à l'introduction d'un nouvel outil de modélisation - les Réseaux de Petri à Intervalles - pour répondre à un besoin de spécification, validation et évaluation des systèmes de production intégrant des contraintes d'intervalles de validité sur une qualité donnée. Le premier chapitre situe la contribution applicative par rapport à l'état de l'art en la restreignant à la régulation sur la commande locale pour les ateliers en fonctionnements répétitifs. Ensuite, L'extension de certaines propriétés structurelles des réseaux de Petri P-temporels à des problématiques non temporelles est alors étudiée avec ce nouvel outil. La deuxième partie de ce travail développe une validation applicative sur une manufacture de tabac. Une construction systématique du modèle Réseaux de Petri à Intervalles est proposée. La méthodologie s'appuie sur les statistiques de production de l'atelier. En s'appuyant sur ce modèle, un réglage est analytiquement calculé en prenant en compte les spécifications de robustesse. Ensuite, une commande réactive est proposée pour faire face aux dérives lentes du procédé. Enfin, l'efficacité de la conduite est démontrée en la simulant sur un ensemble de données de production différent de celui qui a été utilisé pour la construction du modèle. Le présent travail a donc introduit un outil de modélisation dont la pertinence est avérée, au moins sur ce type d'application. Reste que l'abstraction fonctionnelle de l'outil ouvre des champs applicatifs qui restent à explorer, tant d'un point de vue analyse que d'un point de vue mise en œuvreIn the first part of this work, a new modeling tool - Interval Constrained Petri Nets (ICPN) - is introduced to allow us specify, validate and evaluate the performance of the production systems integrating constraints of validity intervals. In a first step, the applicative contribution of this new model in comparison with the methods and tools being used is presented. This applicative contribution is limited to regulation of local control for workshops in a repetitive functioning mode. After that, the extension of some structural properties of P-time Petri Nets of this new tool on non temporal constraints is studied. Part tow of this work develops an applicative validation on a tobacco manufacturing. A systematic methodology based on production data is proposed to construct the model Interval Constrained Petri Nets. This new model used to calculate a setting taking into account robustness specifications. Then, a reactive control is proposed in order to take into account drifts in the process. The control law thus obtained is validated using a second set of production data. The present work therefore introduces a new modeling tool whose pertinence is proved, at least of this type of application. However, the functional abstraction of this tool opens fields of application that have yet to be explored
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Pedreira, Gonçalo Gomes Ferreira Marques. "Identificação e análise de variáveis com influência no intervalo livre de doença pós-cirúrgico de neoplasias malignas orais no cão : um estudo retrospetivo." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/19749.
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Dissertação de Mestrado Integrado em Medicina VeterináriaA cavidade oral é a quarta localização anatómica mais comum no cão para o desenvolvimento de cancro. As neoplasias malignas não odontogénicas caninas mais comuns são, por ordem decrescente de prevalência, o melanoma maligno, o carcinoma espinocelular, o fibrossarcoma e o osteossarcoma. A maioria são tumores com comportamento invasivo, podendo ocorrer metastização, sendo a excisão cirúrgica com amplas margens a abordagem terapêutica mais rápida, económica e eficaz. Massas com maior dimensão e com localização caudal apresentam pior prognóstico. Apesar das melhorias nas técnicas de diagnóstico e na abordagem terapêutica que se tem visto ao longo das últimas décadas, continua a haver uma grande taxa de recidiva e mortalidade nestas neoplasias devido à dificuldade de deteção destas e em conseguir uma excisão cirúrgica completa. Neste estudo retrospetivo o objetivo foi estudar que variáveis clínicas e histopatológicas influenciam o prognóstico de 43 cães com neoplasias orais malignas submetidas a cirurgia associada ou não a quimioterapia. Não houve predisposição de género, a idade mediana foram 10 anos, a localização mais frequente foi a maxilar caudal, o tipo histológico mais prevalente foi o carcinoma espinocelular, a taxa de recidiva local foi de 32,5%, 17 casos tinham margens contaminadas e a taxa de mortalidade foi de 48,8% ao fim de 3 anos de acompanhamento. Foi identificada associação do intervalo livre de doença com o tipo histológico, o estado das margens histológicas, o tamanho e a localização tumorais.
ABSTRACT - Identification and analysis of variables with influence on the post-surgical disease-free interval in malignant oral neoplasia in the dog – a retrospective study - The oral cavity is the fourth most common anatomical location in the dog for the development of cancer. The most common non odontogenic oral malignant neoplasms are, by decreasing prevalence, the malignant melanoma, squamous cell carcinoma, fibrosarcoma and osteosarcoma. Most are tumours with invasive behaviour, metastasis may occur, and surgical excision with wide margins is the fastest, most economical and effective therapeutic approach. Larger masses with caudal location have worst prognosis. Despite the improvements in diagnostic techniques and therapeutic approaches that have been seen over the last decades, there is still a high rate of recurrence and mortality in these cancers due to the difficulty in detecting them and achieving complete surgical excision. In this retrospective study the objective was to study which clinical and histopathological variables influence the prognosis of 43 dogs with malignant oral neoplasms submitted to surgery associated or not with chemotherapy. There was no gender predisposition, the median age was 10 years, the most frequent location was in the maxilla and caudal, the most prevalent histological type was squamous cell carcinoma, the local recurrence rate was 32.5%, 17 cases had contaminated margins and the mortality rate was 48.8%. An association was identified between disease- free interval and histological type, completeness of histological margins, tumour size and location.
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Goze, Nicolas. "N-ary algebras. Arithmetic of intervals." Phd thesis, Université de Haute Alsace - Mulhouse, 2011. http://tel.archives-ouvertes.fr/tel-00710165.
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This thesis has two distinguish parts. The first part concerns the study of n-ary algebras. A n-ary algebra is a vector space with a multiplication on n arguments. Classically the multiplications are binary, but the use of ternary multiplication in theoretical physic like for Nambu brackets led mathematicians to investigate these type of algebras. Two classes of n-ary algebras are fundamental: the associative n-ary algebras and the Lie n-ary algebras. We are interested by both classes. Concerning the associative n-ary algebras we are mostly interested in 3-ary partially associative 3-ary algebras, that is, algebras whose multiplication satisfies ((xyz)tu)+(x(yzt)u)+(xy(ztu))=0. This type is interesting because the previous woks on this subject was not distinguish the even and odd cases. We show in this thesis that the case n=3 can not be treated as the even cases. We investigate in detail the free partially associative 3-ary algebra on k generators. This algebra is graded and we compute the dimensions of the 7 first components. In the general case, we give a spanning set such as the sub family of non zero vector is a basis. The main consequences are the free partially associative 3-ary algebra is solvable. In the free commutative partially associative 3-ary algebra any product on 9 elements is trivial. The operad for partially associative 3-ary algebra do not satisfy the Koszul property. Then we study n-ary products on the tensors. The simplest example is given by a internal product of non square matrices. We can define a 3-ary product by taking A . ^tB . C. We show that we have to generalize a bit the definition of partial associativity for n-ary algebras. We then introduce the products -partially associative where is a permutation of the symmetric group of degree n. Concerning the n-ary algebras, two classes have been defined: Filipov algebras (also called recently Lie-Nambu algebras) and some more general class, the n-Lie algebras. Filipov algebras are very important in the study of the mechanic of Nambu-Poisson, and is a particular case of the other. So to define an approach of Maurer-Cartan type, that is, define a scalar cohomology, we consider in this work Fillipov as n-Lie algebras and develop such a calculus in the n-Lie algebras frame work. We also give some classifications of n-ary nilpotent algebras. The last chapter of this part concerns my work in Master on the Poisson algebras on polynomials. We present link with the Lie algebras is clear. Thus we extend our study to Poisson algebras which associated Lie algebra is rigid and we apply these results to the enveloping algebras of rigid Lie algebras. The second part concerns intervals arithmetic. The interval arithmetic is used in a lot of problems concerning robotic, localization of parameters, and sensibility of inputs. The classical operations of intervals are based of the rule : the result of an operation of interval is the minimal interval containing all the result of this operation on the real elements of the concerned intervals. But these operations imply many problems because the product is not distributive with respect the addition. In particular it is very difficult to translate in the set of intervals an algebraic functions of a real variable. We propose here an original model based on an embedding of the set of intervals on an associative algebra. Working in this algebra, it is easy to see that the problem of non distributivity disappears, and the problem of transferring real function in the set of intervals becomes natural. As application, we study matrices of intervals and we solve the problem of reduction of intervals matrices (diagonalization, eigenvalues, and eigenvectors).
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Nunes, Daniela Sharon de Souza. "Patologia clínica de gatas com tumores mamários submetidas a quimioterapia com doxorrubicina." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2014. http://hdl.handle.net/10400.5/6797.
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Dissertação de Mestrado Integrado em Medicina VeterináriaA maioria das neoplasias mamárias na espécie felina é maligna e muito agressiva, traduzindo-se num elevado poder invasivo e capacidade de metastização. Por conseguinte, tem havido vários tentativas para usar a quimioterapia como adjuvante à cirurgia, de modo a prolongar a sobrevivência destes animais. Todavia, a eficácia desta terapêutica ainda não está completamente estabelecida. Deste modo este estudo tem como objetivo avaliar o benefício da quimioterapia como complemento da cirurgia. Este estudo retrospetivo incidiu na análise de 46 animais (grupo 1 - gatas tratadas cirurgicamente, n=32; grupo 2 - gatas tratadas com cirurgia e quimioterapia com doxorrubicina, n=14) com carcinomas mamários, diagnosticados no Laboratório de Anatomia Patológica da FMV-UL, tendo sido comparadas as diferenças entre os dois grupos de tratamento no que diz respeito ao tempo de sobrevida e ao intervalo livre de doença. Adicionalmente avaliou-se a influência de alguns fatores no tempo de sobrevida e no intervalo livre de doença das gatas pertencentes ao grupo 2. Foram avaliadas as diferenças entre os dois grupos das variáveis clínicas e histopatológicas, nos dois grupos. Em relação ao tempo de sobrevida, o grupo 1 apresentou um valor de mediana de 292 dias face aos 776 dias pertencentes aos animais do grupo 2 (p= 0,053). Quanto ao intervalo livre de doença, obtiveram-se os valores de 292 dias e 1199 dias para os grupos 1 e 2, respetivamente (p= 0,200). Comparando os dois grupos em relação ao tempo de sobrevida, tendo em conta os diversos fatores analisados, não se verificaram diferenças significativas à exceção do subgrupo da raça Europeu Comum (p=0,022) e do subgrupo com presença de necrose (p= 0,043). Relativamente ao intervalo livre de doença, ao comparar os dois grupos, também não se verificaram diferenças significativas exceto no subgrupo de idade < 10 anos (p=0,025) e no subgrupo de tumores com ausência de necrose (p=0,023). Não foram encontradas outras diferenças significativas quer na avaliação dos diferentes fatores no tempo de sobrevida e no intervalo livre de doença, quer no estudo das variáveis clínicas e histopatológicas. O uso da quimioterapia adjuvante com doxorrubicina apresenta neste estudo um resultado benéfico, necessitando no entanto de investigação adicional, nomeadamente de estudos prospetivos.
ABSTRACT - CLINICAL PATHOLOGY IN CATS WITH BREAST TUMORS UNDERGOING CHEMOTHERAPY WITH DOXORUBICIN - Most mammary tumors in feline species are malignant and very aggressive, resulting in highly metastatic and invasive tumors. Therefore, various attempts have been made to use adjuvant chemotherapy following surgery in order to prolong the survival of these animals. However, the effectiveness of this treatment is not yet very well established. Hence, this study aims to evaluate the benefit of adjuvant chemotherapy compared to surgery alone. This retrospective study focused on the analysis of 46 animals (group 1 - cats treated surgically, n = 32 ; group 2 - cats treated with surgery and chemotherapy with doxorubicin, n = 14) with breast carcinomas diagnosed in the Laboratório de Anatomia Patológica da FMV-UL, comparing the differences between the two treatment groups regarding survival time and disease-free interval. Additionally, the influence of some factors on survival time and disease-free interval of the cats from group 2 was evaluated. Clinical data and histopathological variables were analysed in the two groups. Group 1 had a median survival time of 292 days compared to 776 days in group 2 (p=0.053). Median disease-free interval times for group 1 and 2 were 292 days and 1199 days, respectively (p=0.200). Comparing the two groups in relation to survival time, no significant differences were found taking into account the several factors analyzed, except for the subgroup of the European shorthair cats (p=0.022) and the subgroup with the presence of necrosis (p= 0.043). Regarding disease-free interval, when comparing the two groups, there were no significant differences except in the subgroup of age <10 years (p=0.025) and in the subgroup of tumors with absence of necrosis (p=0.023). No other significant differences were found in the analysis, neither for the survival times and disease-free interval nor in the clinical and histopathological variables. The use of adjuvant chemotherapy with doxorubicin in this study shows a benefic result, however it requires further investigation, including prospective studies.
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PAIVA, Carina Batista. "Associação da expressão do Ki67 e linfonodos axilares metastáticos com a sobrevida livre de doença no câncer de mama invasivo." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/20411.
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Marcadores biológicos são requeridos para estimar o risco de recorrência da doença em mulheres com câncer de mama. O Ki67 é um marcador de proliferação celular e seu valor preditivo e prognóstico tem sido estudado como um importante biomarcador de rotina na prática clínica. Nosso estudo teve como objetivo avaliar a relação entre a intensidade da expressão do Ki-67 e o envolvimento de linfonodos axilares com metástases com a sobrevida livre de doença em mulheres com câncer de mama. Esse estudo foi retrospectivo e 134 pacientes foram elegíveis para o estudo. A associação entre os escores do Ki67 e outros fatores prognósticos, tais como tamanho do tumor, grau, status dos linfonodos axilares, invasão perineural e linfovascular, biomarcadores RE, RPg e HER-2 foram avaliados, além da análise de sobrevivência. Dos 134 pacientes, 53 tiveram recorrência da doença. O valor da mediana dos escores do Ki67 foi de 30% de todos os pacientes. Um total de 78 (58,25) dos pacientes tiverm escores alto do Ki67. A associação estatisticamente significante foi entre os escores altos do Ki67 com o grau histológico (p<0.001), subtipos moleculares (p<0.001), receptores de estrógeno (p=0.023) e receptores de progesterona (p=0.001). A sobrevida livre de doença em indivíduos com Ki67 alto e axila clinicamente negativa apresentou um menor tempo em meses em comparação com os indivíduos com escores do Ki67 baixo (p=0.049).
Biological markers are required to estimate the risk of disease recurrence in women with breast cancer. The Ki 67 is a cell proliferation marker and its predictive and prognostic value has been studied as an important marker in routine clinical practice. Our study aimed to evaluate the relationship between the intensity of Ki67 expression and involvement of axillary lymph nodes with metastases to the disease-free survival in women with breast cancer. This was a retrospective study and 134 patients were eligible for the study. The association between the scores of Ki67 and other prognostic factors such as tumor size, grade, status of axillary lymph nodes, perineural invasion and lymphovascular, in addition to biomarkers ER, PgR, and HER2 were evaluated, as well as survival analysis. Of the 134 patients, 53 have had recurrence of disease. The median value of Ki scores 67 was 30% of all patients. A total of 78 (58.25) of the patients had high scores Ki 67. A statistically significant association was between high scores of Ki67 with the histological grade, molecular subtypes of progesterone receptors estrogen receptors. A statistically significant association was between high scores of Ki67 with the histological grade (p <0.001), molecular subtypes (p <0.001), estrogen receptor (p = 0.023) and progesterone receptors (p = 0.001). The disease-free survival in patients with high Ki67 and clinically negative axilla had a shorter time in months compared to individuals with low Ki67 scores (p = 0.049).
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Filho, Paulo Roberto de Alcantara. "Caracterização molecular de tumores de mama triplo-negativos com diferença de expressão de SPARC." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-16112017-091605/.
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O câncer de mama triplo negativo (TNBC) é um dos tumores mais agressivos, muitas vezes resistentes à terapia sistêmica e com evolução para doença metastática. O entendimento de sua biologia e a concepção de novos tratamentos são essenciais para melhorar o seu prognóstico. Atualmente, as opções de tratamento são reduzidas e a quimioterapia ainda é o tratamento padrão. A expressão de SPARC (secreted protein acidic and rich in cysteine) é supostamente alterada em várias doenças malignas. No entanto, pouco se sabe sobre o valor prognóstico do SPARC em pacientes com TNBC. Usando uma pequena coorte de descoberta de TNBC muito bem caracterizada em relação à expressão do SPARC e comportamento clínico, conseguimos identificar vários genes como diferencialmente expressos na comparação entre amostras de TNBC / SPARC negativo vs. TNBC / SPARC positivo. Cinco desses genes diferencialmente expressos, SOHLH2, DNAJC12, LIM-1, CEACAM-5 e CTAG1A foram escolhidos para serem validados por imuno-histoquímica (IHC) em tissue microarrays (TMAs) contendo uma coorte independente de TNBC. Para acessar o valor prognóstico desses potenciais novos biomarcadores, avaliamos a associação entre a expressão de IHC e os resultados das pacientes pela análise de Kaplan-Meier para a coorte de validação. Foi observado que a coloração negativa da expressão de SOHLH2 e coloração positiva de DNAJC12 e LIM1 mostrou uma tendência a ser correlacionada com um pior prognóstico tanto para a sobrevida livre de doença quanto para sobrevida global. Nossos resultados fornecem novas informações sobre alterações transcriptômicas associadas ao comportamento clínico de TNBC que podem servir como ferramenta potencial para a identificação e caracterização de novos biomarcadores candidatos como fatores prognósticos e preditivos para pacientes com TNBC no futuroTriple-negative breast cancer (TNBC) is one of the most aggressive, therapy-resistant, and metastatic tumors. Understanding of its biology and designing new treatments are essential to improve its prognosis. Currently, treatment options are reduced, and chemotherapy is still the standard treatment. SPARC (secreted protein acidic and rich in cysteine) expression is reportedly altered in various malignancies. However, little is known regarding the prognostic value of SPARC in TNBC patients. Using a small discovered cohort of TNBC very well characterized regarding SPARC expression status and clinical behavior, we were able to identify several genes as differentially expressed in the comparison between TNBC/SPARC negative vs. TNBC/SPARC positive samples. Five of these differentially expressed genes, SOHLH2, DNAJC12, LIM, CEACAM-5 and CTAG1A were chosen to be validated by immunohistochemistry (IHC) on tissue microarrays (TMAs) containing an independent cohort of TNBC. To access the prognostic value of these potential new biomarkers, we evaluated the association between the IHC expression and patient\'s outcomes by Kaplan-Meier analysis for the validation cohort. We found that negative staining of SOHLH2 expression and positive staining of DNAJC12 and LIM1 showed a trend to be correlated with a poor prognosis for both disease-free survival and overall survival. Our findings provide new information on transcriptome changes associated the clinical behavior of TNBC that may serve as a potential tool for the identification and characterization of new candidate biomarkers as prognostic and predictive factors for patients with TNBC in the future
Books on the topic "Intervalle libre"
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Annie, Cœurdevey, Bent Margaret, Powers Harold, Blackburn Bonnie J, and Centre d'études supérieures de la Renaissance. Programme Ricercar., eds. Lire composer, analyser à la Renaissance. Minerve, 2003.
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Apezteguía, María del Carmen, and Julieta Ferrario, eds. Probabilidades y estadística. Editorial de la Universidad Nacional de La Plata (EDULP), 2019. http://dx.doi.org/10.35537/10915/74877.
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Este libro intenta dar una introducción a las ideas básicas de Probabilidades y Estadística. Fue concebido para ser usado por los estudiantes del ciclo básico de la Facultad de Ciencias Exactas de la UNLP (CiBEx), con conocimientos básicos de Análisis Matemático. La temática puede considerarse dividida en dos núcleos centrales: 1. Nociones básicas de probabilidades: son las herramientas necesarias para desarrollar las primeras nociones de inferencia estadística. 2. Algunos elementos de inferencia estadística: estimación puntual y mediante intervalos de confianza, test de hipótesis, regresión lineal. La gran mayoría de los temas son introducidos con ejemplos, tratando de enfatizar la manera correcta de encararlos.
Conference papers on the topic "Intervalle libre"
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"Modificación del intervalo QT tras el uso de Sevofluorano Propofol." In Resúmenes de trabajos libres congreso CLASA 2019. Sociedad de Anestesiología de Chile, 2019. http://dx.doi.org/10.25237/congresoclasa2019.102.
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van Velzen, L. P. M., M. Bruggeman, and J. Botte. "Proficiency Test for Non-Destructive Assay of 220 Litre Radioactive Waste Drums by Gamma Assay Systems." In The 11th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2007. http://dx.doi.org/10.1115/icem2007-7236.
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The European Network of Testing Facilities for the Quality Checking of Radioactive Waste Packages (ENTRAP) initiated a feasibility study on how to organize in the most cost effective way an international proficiency tests for non-destructive, gamma-ray based, assay of 220 liter radioactive waste drums in the European Union at a regular time interval of 2 or 3 years. This feasibility study addresses all aspects of proficiency testing on radioactive waste packages including the design of a commonly accepted reference 220 liter drum. This design, based on the international response on a send out questionnaire, includes matrixes, radioactive sources; a solution to overcome the tedious and expensive international transport costs of real or even simulated waste packages, general cost estimation for the organization of, and the participation in the proficiency test. The proposed concept for the proficiency testing and the estimated costs are presented. The participation costs of the first proficiency test are mainly determined by the manufacturing of the non-radioactive 220 liter drum (± 55%). Applied reference sources, transport of the drum and reference sources and participation costs in the proficiency test contribute each about ± 15%.
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Giddings, J. C. "AN IMMUNORADIOMETRIC ASSAY (IRMA) FOR HUMANTHROMBOMODULIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643963.
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Thrombomodulin was separated from detergent-soluble fractions of human placenta using a combination of DEAE-Sepharose and thrombin-Sepharose chromatography. The final product demonstrated one major band (Mr approximately 100000) and three minor bands (Mr 40000 - 80000) on SDS-polyacrylamide gel electrophoresis. The purified protein markedly enhanced the rate of activation of human protein C by thrombin in the presence of calcium ions. Polyclonal antibodies to the isolated thrombomodulin were raised in rabbits and were shown to inhibit thrombin co-factor activity. Immunofluorescence of fibroblasts and of human umbilical vein endothelial cells in culture demonstrated that thrombomodulin antigen was specifically located in endothelial cell membranes. Affinity purified antibody was labelled with 125I and was used to establish an immunoradiometric assay (IRMA). The method was sensitive to approximately 10.0μg purified thrombomodulin per litre. The concentration of thrombomodulin in detergent-solubilised endothelial cells obtained at intervals during primary culture was proportional to the number of cells harvested for assay and appeared to reflect cell growth. Confluent cells from four experiments (approximately 2 × 106 cells per culture dish) contained on average 8.4ng thrombomodulin. Incubation of confluent endothelial cells with medium containing 1 unit per ml human α-thrombin for 10 mins at 37°C reduced the amount of cellular thrombomodulin detected in this assay by up to 30%. Assays of human plasma confirmed that low levels of thrombomodulin are present in normal circulating blood. A mean level of 160μg per litre was detected in 20 normal donors. The levels of thrombomodulin antigen in 10 normal serum were not significantly different from those in the corresponding normal plasma. Preliminary results illustrated that increased levels of thrombomodulin might be found in the plasma of some patients with a variety of clinical disorders. The data suggest that quantitative assays of thrombomodulin might provide a useful index of endothelial disturbances in vivo.