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Dissertations / Theses on the topic 'Intervertebral disc'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Stefanakis, Manos. "Biomechanics of intervertebral disc pain." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556723.

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'Background: Back pain is strongly (but variably) associated with degeneration of intervertebral discs. Mechanical loading has long been considered one of the causes of disc pathology and pain, but its precise role is poorly understood. In particular the spatial relation between load distribution inside the disc, the disc matrix changes as a result of load and their relationship with pain has not been researched. Methods: Distribution of compressive stress inside intervertebral discs from all regions of the spine was studied using stress profilometry in cadaveric motion segments. Matrix pathol

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2

Lemos, Felipe Fernandes [UNESP]. "Influência da desidratação no comportamento mecânico do disco intervertebral lombar." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/105330.

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Made available in DSpace on 2014-06-11T19:34:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-22Bitstream added on 2014-06-13T21:06:51Z : No. of bitstreams: 1 lemos_ff_dr_guara_parcial.pdf: 67760 bytes, checksum: 8abbb6c32f12d888cf49226d69fd138e (MD5) Bitstreams deleted on 2014-10-03T16:24:39Z: lemos_ff_dr_guara_parcial.pdf,Bitstream added on 2014-10-03T16:27:37Z : No. of bitstreams: 2 lemos_ff_dr_guara_parcial.pdf.txt: 11034 bytes, checksum: 59c288b2b373bbe58255effddd89bb52 (MD5) 000671151.pdf: 2407167 bytes, checksum: 0e13b6a8dfac5d68060ec4460476f509 (MD5) Bitstreams deleted

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González, Guitiérrez Ramiro Arturo. "Biomechanical study of intervertebral disc degeneration." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/76781.

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Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend and torsion loads, statically or dynamically, with load magnitudes corresponding to the physiological range. However, traditional testing does not give a view of the load and deformation states of the disc components: nucleus pulposus, annulus f

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4

Osti, Orso L. "Annular tears and intervertebral disc degeneration /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09pho85.pdf.

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5

Liu, Jane J. "Proteoglycans of the human intervertebral disc." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68204.

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The composition and heterogeneity of human intervertebral disc proteoglycans from different aged individuals were investigated. (1) The glycosaminoglycan content in the nucleus pulposus was greater than that in the annulus fibrosus at all ages. Glycosaminoglycan content increased from the infant to the young adult, and then decreased from the young to the mature adult. (2) Disc contained a higher content of hyaluronate than articular cartilage at all ages. (3) Proteolytically modified LP3 was predominant in the disc. (4) Very low link protein concentrations were observed in adult disc proteogl

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6

Naish, Claudia Martha. "Ultrasound imaging of the intervertebral disc." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288301.

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7

Molinari, Michael B. "Mechanical fractionation of the intervertebral disc." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:7385c54f-a3d0-4467-aca4-c7a9b8686982.

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Chronic lower back pain is a major public health problem, with direct and indirect economic costs comparable to those of heart disease, depression and diabetes. In many cases this pain derives from degeneration of the intervertebral disc (IVD), a fibrous, avascular tissue that sits between the vertebrae in the spinal column. A novel treatment approach for this ‘discogenic’ pain is the injection of a hydrogel that hybridises in situ and restores the normal biomechanical function of the disc. While a number of promising materials are currently under development, existing approaches to removing d

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8

Luxmoore, Bethany Jane. "Computational simulation of the intervertebral disc." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4685/.

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The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of these tissues is not well understood. The aim of this project was to investigate methods of deriving structural information about the tissues of the intervertebral disc for application in computational simulation, with particular focus on the mechanical function of the annulus fibrosis and how the behaviour of this tissue is governed by its su

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9

Jim, Jin-to. "Genetics and molecular characterization of degenerative disc disease." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35720189.

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10

Chan, Kit-ying, and 陳潔瑩. "Development of whole disc organ culture system and acellular disc scaffold for intervertebral disc engineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45600077.

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11

Jim, Bernice. "Early developments of an intervertebral disc model using bovine coccygeal discs." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110397.

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Degeneration of the lumbar disc, which frequently leads to low back pain, is an age related disease that often diminishes a patient's quality of life. Despite the continued efforts of research in this area, biological understanding of the disease remains unclear. The treatment strategies are few, with the gold standard being fusion of the motion segment, which permanently prevents any motion at the treated level of the spine. Although there are several new treatments available that attempt to recover some mechanical function of the motion segment, such as arthroplasty, they all remain unsatisf

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12

Lemos, Felipe Fernandes. "Influência da desidratação no comportamento mecânico do disco intervertebral lombar /." Guaratinguetá : [s.n.], 2011. http://hdl.handle.net/11449/105330.

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Resumo: A desidratação do núcleo pulposo que, juntamente com o anulus fibroso, compõe o disco intervertebral, participa do processo de degeneração da coluna vertebral. Torna-se importante entender como este processo de desidratação e a consequente alteração das propriedades mecânicas influenciam na biomecânica dessa articulação. O principal objetivo deste estudo é analisar a influência da desidratação no coeficiente de amortecimento viscoso e como esta variação pode alterar o comportamento mecânico do disco intervertebral lombar. Este estudo é composto de duas etapas: na primeira, o coeficient

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13

Kelempisioti, A. (Anthi). "Genetic risk factors for intervertebral disc degeneration." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526211350.

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Abstract Low back pain (LBP) is the leading cause of years lived with disabilities worldwide. Intervertebral disc (IVD) degeneration is a strong contributing factor to LBP. Recent studies have shown that genetic determinants contribute markedly to IVD degeneration but knowledge about the actual genes involved as well as their roles is still limited. The aim of this thesis work was to study genetic factors that may predispose to IVD degeneration. Using both family and case-control association study designs, variants in five genes showed association with IVD degeneration on magnetic resonance im

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14

Hristova, Gergana. "Calcification in Intervertebral Disc Degeneration and Scoliosis." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86948.

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In degenerative and scoliotic intervertebral discs (IVD), calcification is a pathological process that may lead to impairment of the nutrient supply and a disturbance in disc metabolism. However, the process of calcification in disc degeneration and scoliosis is not well understood. The purpose of this study was to assess the calcification markers in IVD of patients with degenerative disc disease and adolescent idiopathic scoliosis. For this purpose, 34 IVDs from 16 adult patients with degenerative disc disease and 25 IVDs from 9 adolescent patients with adolescent idiopathic scoliosis were ob

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15

Lam, Ka-lok Stephen, and 林家樂. "Biomechanics of the intervertebral disc allograft transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43773904.

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16

Johnson, Scott. "Scanning acoustic microscopy of the intervertebral disc." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393922.

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17

Fahmy, Amr. "Measuring the pressure of the intervertebral disc." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/361604/.

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Spinal musculoskeletal conditions are an economical burden; in the United States alone, the annual cost of these conditions is estimated to be $254 billion. These conditions are also a social burden; in the United States, for example, musculoskeletal problem is the number one reason for a visit to a physician. Most of these conditions are caused by degenerative changes in the vertebral column. Such degenerations are, often, the result of long-term changes in the intervertebral disc pressure. To date, the standard methodology to measure this pressure suffers from being invasive, which prevents

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18

Lam, Ka-lok Stephen. "Biomechanics of the intervertebral disc allograft transplantation." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43773904.

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19

Ho, Wai-hung Daniel. "Genetic study of lumber disc degeneration." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841215.

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20

Bibby, Susan R. S. "Cell metabolism and viability in the intervertebral disc." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249331.

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21

Jackson, Alicia R. "Transport and Metabolism of Glucose in Intervertebral Disc." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/479.

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Low back pain is a major social and economic dilemma in the United States. Despite its high impact, the origins of low back remain unclear. Nonetheless, degenerative changes to the intervertebral discs (IVD) of the spine have been implicated as a possible source leading to pain. Poor nutritional supply to the IVD is believed to play a primary role in the pathophysiology of disc degeneration. Since the disc is avascular, vital nutrients, such as glucose, must be supplied by surrounding blood vessels. However, the transport and metabolic properties of glucose in the IVD have not been full

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22

Walters, Rebecca. "Lumbar intervertebral disc infection pathology, prevention and treatment /." Click here to access, 2006. http://thesis.library.adelaide.edu.au/public/adt-SUA20061011.164644/index.html.

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Thesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, Discipline of Pathology, 2006.<br>Includes author's previously published papers. "March 2006" Includes bibliographical references. Also available in a print form.

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23

Hudgins, Robert Garryl. "Development and characterization of a prosthetic intervertebral disc." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/20675.

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24

Pockert, Aneta Joanna. "Aggrecanolytic ADAMTS Expression in Human Intervertebral Disc Degeneration." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492880.

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Low Back Pain (LBP) affects 60-80% of the population at some point in their lives with approximately 10% of sufferers being chronically disabled. Degeneration of the intervertebral disc (DIVD) has been identified as one of the main causes of LBP.

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25

Chan, Chun-wai, and 陳春慧. "In-vitro study of the cryopreserved intervertebral disc." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290380.

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26

Lim, Foon Lian. "Role of cadherin 2 in the intervertebral disc." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198869.

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Intervertebral disc (IVD) degeneration could lead to many serious complications including low back pain and disc herniation. However, the mechanism of disc degeneration is not fully understood, hindering the development of the therapeutics to cure this disease. The integrity of the nucleus pulposus (NP), which is derived from the notochord and situated in the core of the IVD, has long been implicated in the function and homeostasis of the IVD. Previous puncture-induced disc degeneration mouse model showed segregation of NP cell mass during the early stage of disc degeneration, indicating that

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27

Palfrey, Rachel Melanie. "The anatomy and microcirculation of the intervertebral disc." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/16138.

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Low back pain is a costly financial and loss of productivity societal issue. Although its aetiology is unclear, it has been associated with the intervertebral disc and its degeneration which has been thought to be caused in part by poor nutrition. In this thesis the caudal disc of skeletally mature equines is utilised as an animal model. Techniques such as x-ray, light imaging, histology and magnetic resonance imaging were employed to investigate the vascular and structural anatomy of the disc and its surroundings and the uptake of tracers within the disc tissue. A detailed study of the anatom

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28

Chan, Chun-wai. "In-vitro study of the cryopreserved intervertebral disc." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290380.

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29

Moore, Robert James. "Vascularization of the intervertebral disc in pathological conditions /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phm8233.pdf.

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30

Wang, Shaobai. "In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/70430.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Knowledge of lumbar spine biomechanics in living human subjects is fundamental for understanding mechanisms of spinal injury and pathology, for improvement of corresponding clinical treatments, and for design of spinal prosthesis. However, due to the complicated spine anatomy and loading conditions as well as high risks in these direct measurements, it has been a challenge to determine the in vivo biomechanics of the

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31

Chokhandre, Snehal K. "A Biomechanical Comparison Between a Biological Intervertebral Disc and Synthetic Intervertebral Disc Implants Under Complex Loading: An In Vitro Study." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1187022568.

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32

Jim, Jin-to, and 詹展韜. "Genetics and molecular characterization of degenerative disc disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35720189.

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33

Baumhardt, Raquel. "TRATAMENTO CLÍNICO DE CÃES COM DIAGNÓSTICO PRESUNTIVO DE DOENÇA DO DISCO INTERVERTEBRAL." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/10201.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Intervertebral disc disease (IVD) is a common pathology in clinical neurology of dogs, representing 45.8% of neurological cases treated at Veterinary Hospital of the Universidade Federal de Santa Maria. The most affected segments are the thoracolumbar (T3-L3) and cranial cervical (C1-C5) of the spinal cord. The clinical sign occurs due a combination of the compressive effect of the disc material and the injury of impact on spinal cord, probably due to an extrusion. A clinical sign varies according to the affected segment of the s

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34

Travascio, Francesco. "Modeling Molecular Transport and Binding Interactions in Intervertebral Disc." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/322.

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Low back pain represents a significant concern in the United States, with 70% of individuals experiencing symptoms at some point in their lifetime. Although the specific cause of low back pain remains unclear, symptoms have been strongly associated with degeneration of the intervertebral disc. Insufficient nutritional supply to the disc is believed to be a major mechanism for tissue degeneration. Understanding nutrients' transport in intervertebral disc is crucial to elucidate the mechanisms of disc degeneration, and to develop strategies for tissue repair (in vivo), and tissue engineering (in

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35

Antoniou, John. "Quantitative biochemical changes in the human lumbar intervertebral disc." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0028/NQ50103.pdf.

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36

Vignollet, Julien. "Computational strategies toward the modelling of the intervertebral disc." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3774/.

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Lumbar back pain has considerable socio-economical impacts, motivating a recently increasing interest from the research community. Yet, mechanisms triggering pain are not fully understood and this considerably hinders the development of efficient treatments and therapies. The objective of this thesis is to participate to the general understanding of the biomechanics of the spine through the development of computational strategies for the intervertebral disc. The intervertebral disc is a complex structure mainly comprised of the nucleus pulposus and the annulus fibrosus. The nucleus pulposus is

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37

Ho, Grace, and 何秀慧. "Intervertebral disc regeneration by use of autologous mesenchymal stemcells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31541616.

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38

Lam, To-kam, and 林吐金. "Fate of notochord descendent cells in the intervertebral disc." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50567160.

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39

Alexander, Lyndsay Ann. "The effect of position on the lumbar intervertebral disc." Thesis, Robert Gordon University, 2014. http://hdl.handle.net/10059/1020.

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This thesis comprises three phases with a combined aim which was to investigate the effect of position on the lumbar intervertebral disc (IVD). The effect of position on the lumbar IVD in asymptomatic subjects and subjects with discogenic low back pain (DLBP) was explored using positional Magnetic Resonance Imaging (pMRI). Convenience samples of 11 asymptomatic and 34 DLBP subjects were recruited to have sagittal and axial pMRI scans performed in sitting (Neutral, Flexed and Extended), standing and lying (Supine and Prone extension) positions. The sagittal plane migration of the nucleus pulpos

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40

Lee, Tsz Yan Juliana. "Technique and method development for intervertebral disc (IVD) research." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/43799.

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Intervertebral disc (IVD) degeneration is one of the major causes of low back pain. The direct and indirect cost of managing back pain posts heavy socioeconomic burden to the society. Improved technologies and techniques together with well documented experiments will benefit the research field by saving effort in doing the optimization in every laboratory and avoiding experiment failure due to incomplete understanding of the procedures. These can accelerate scientific discovery, reduce the sacrifice of animals and enable a more effective use of funding. Nucleus pulposus (NP) is the central par

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41

Wan, Simon. "Self-assembling peptide hydrogel for intervertebral disc tissue engineering." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/selfassembling-peptide-hydrogel-for-intervertebral-disc-tissue-engineering(1f931e1e-6b9b-49a7-bd30-2572ff0338fa).html.

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The intervertebral disc (IVD), situated between adjoining vertebrae, consists of the gelatinous nucleus pulposus (NP) in the centre surrounded by the tougher annulus fibrosus (AF). Its main roles are to distribute loads and to act as joints. With aging, degenerative disc disease (DDD) occurs due to an imbalance in anabolic and catabolic events in the IVD, which results in a loss of function. Lower back pain (LBP) affects 84% of people at some point in their lifetime and is strongly associated with DDD. Current LBP treatments have limited long term efficacy and are symptomatic rather than curat

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42

Ross, Edward R. S. "Stiffness : a key mechanical factor in normal, degenerate and artificial lumbar intervertebral discs." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3213.

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This thesis describes the development of artificial disc technology for the replacement of intervertebral discs in the human lumbar spine. The clinical problem is back pain. There may be a relationship between certain forms of back pain and disc degeneration. The mechanical properties of human intervertebral discs are examined in detail. The genetic basis of disc degeneration is presented. The hypothesis is that such degeneration leads to a loss of normal stiffness in the segments affected leading to abnormal mechanical behaviour which in turn leads to pain. The evidence for this is presented.

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43

Baptista, Josemberg da Silva. "Análise do envelhecimento e degeneração de discos intervertebrais humanos cervicais e lombares." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-07022014-142752/.

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INTRODUÇÃO: A degeneração do disco intervertebral (DIV) é um processo crônico e apontado como o maior causador de cervicalgia e lombalgia. Esse processo geralmente conta com a degradação da matriz extracelular, expressão de citocinas inflamatórias e fatores angiogênicos e axonogênicos. Entretanto, muito pouco se sabe sobre esse processo em DIVs assintomáticos durante o envelhecimento, principalmente no segmento cervical. O objetivo desse estudo foi de delinear o perfil de moléculas relacionadas à degeneração discal em DIVs cervicais e lombares. MÉTODOS: Discos intervertebrais humanos cervicais

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44

Ho, Wai-hung Daniel, and 何偉雄. "Genetic study of lumber disc degeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841215.

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45

Hoschouer, Clifford Jason. "Material Analysis of the Intervertebral Disc and the use of Flexible Bodies in Disc Modeling." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1321974899.

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46

Casa, Nara Lígia Leão. "Associação entre polimorfismos na região VNTR do gene aggrecan e a hérnia de disco lombar." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/6830.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-02-09T10:36:15Z No. of bitstreams: 2 Dissertação - Nara Lígia Leão Casa - 2015.pdf: 3128154 bytes, checksum: 290faf6f7e255eb06dcfd7b0baf48e03 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-02-09T10:36:36Z (GMT) No. of bitstreams: 2 Dissertação - Nara Lígia Leão Casa - 2015.pdf: 3128154 bytes, checksum: 290faf6f7e255eb06dcfd7b0baf48e03 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made avail

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Ho, Grace. "Intervertebral disc regeneration by use of autologous mesenchymal stem cells." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31541616.

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48

Fernando, Hanan Nirosha. "Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/286.

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Back pain is the second most common neurological ailment in the United States and the leading cause of pain and disability. More than 80% of the total US population experiences back-pain during their life time and the annual back pain related healthcare costs exceed 100 billion dollars. While the exact cause of low back pain (LBP) is still unknown, degeneration of the intervertebral disc (IVD) has been suggested as a primary contributor. IVD is the largest avascular tissue in the human body and it is composed of three integrated tissues (annulus fibrosus - AF, nucleus pulposus - NP and cart

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49

Houben, Gerard Boudewijn. "Swelling and compression of intervertebral disc tissue model and experiment /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6705.

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Dimitri, Helene Karen. "The influence of compensation on recovery following intervertebral disc surgery /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09HS/09hsd5826.pdf.

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