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Journal articles on the topic 'Intervertebral disc'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Jiang, Feng. "Nucleus Pulposus Cell Senescence in IVDD: Mechanisms and Therapeutic Perspectives." International Journal of Biology and Life Sciences 10, no. 1 (2025): 61–67. https://doi.org/10.54097/2ggt8s93.

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Intervertebral disc degeneration (IVDD) is a common spinal pathological process that leads to the degeneration of the structure and function of the intervertebral disc, causing low back pain and nerve root compression. The molecular mechanism of intervertebral disc degeneration is not fully understood, but cellular senescence is an important factor. This article summarizes the characteristics, causes, signal transduction pathways and treatment methods of cellular senescence in intervertebral disc degeneration, including inhibiting the expression or activity of genes or signal pathways related

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2

Chavan, Dr Vishwajeet R., and Dr Sanjay Patil. "Radioneucleoplasty Therapy in Intervertebral Disc Herniation." Indian Journal of Applied Research 4, no. 4 (2011): 441–42. http://dx.doi.org/10.15373/2249555x/apr2014/136.

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3

Bodnarchuk, J. A., M. V. Khyzhnjak, О. О. Potapov, and N. G. Chopik. "BIOCHEMICAL AND BIOMECHANICAL SUBSTANTIATION OF REPARATIVE REGENERATION OF INTERVERTEBRAL DISCS IN PATIENTS WITH DEGENERATIVE DISC DISEASES." Eastern Ukrainian Medical Journal 8, no. 3 (2020): 249–54. http://dx.doi.org/10.21272/eumj.2020;8(3):249-254.

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Degenerative disc diseases occupy the second place in the overall structure of morbidity with temporary disability. In 40% of patients with spinal osteochondrosis, diseases of the locomotor apparatus and connective tissue cause primary disability. Disc degeneration is a pathological process that is the main cause of low back pain and is observed in the vast majority of people at some point in their lives. The influence of mechanical stress leads to degenerative changes in the tissues of the nucleus pulposus of the intervertebral disc. Limited transport and low cellular saturation of the discs

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4

ANDERSSON, GUNNAR B. J., HOWARD S. AN, THEODORE R. OEGEMA, and LORI A. SETTON. "INTERVERTEBRAL DISC DEGENERATION." Journal of Bone and Joint Surgery-American Volume 88, no. 4 (2006): 895–99. http://dx.doi.org/10.2106/00004623-200604000-00028.

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5

KATZ, MICHAEL M., ALAN R. HARGENS, and STEVEN R. GARFIN. "Intervertebral Disc Nutrition." Clinical Orthopaedics and Related Research &NA;, no. 210 (1986): 243???245. http://dx.doi.org/10.1097/00003086-198609000-00035.

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6

Cassidy, J. David, Dwight Loback, Ken Yong-Hing, and Stanley Tchang. "Intervertebral Disc Derniation." Spine 17, no. 5 (1992): 570–74. http://dx.doi.org/10.1097/00007632-199205000-00016.

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7

Fairbank, Jeremy. "Prolapsed intervertebral disc." BMJ 336, no. 7657 (2008): 1317–18. http://dx.doi.org/10.1136/bmj.39583.438773.80.

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8

Bhettay, E., D. Joubert, O. L. Meyers, and B. Cremin. "Intervertebral Disc Calcification." Clinical Pediatrics 31, no. 7 (1992): 446–47. http://dx.doi.org/10.1177/000992289203100714.

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9

Skalli, Wafa, and Jean Dubousset. "Intervertebral disc transplantation." Lancet 369, no. 9566 (2007): 968–69. http://dx.doi.org/10.1016/s0140-6736(07)60469-3.

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10

Wu, Jiann-Jiu, and David R. Eyre. "Intervertebral Disc Collagen." Journal of Biological Chemistry 278, no. 27 (2003): 24521–25. http://dx.doi.org/10.1074/jbc.m302431200.

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11

Rannou, François, Tzong-Shyuan Lee, Rui-Hai Zhou, et al. "Intervertebral Disc Degeneration." American Journal of Pathology 164, no. 3 (2004): 915–24. http://dx.doi.org/10.1016/s0002-9440(10)63179-3.

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12

Luk, Keith D. K., and Dino Samartzis. "Intervertebral disc “dysgeneration”." Spine Journal 15, no. 9 (2015): 1915–18. http://dx.doi.org/10.1016/j.spinee.2014.07.020.

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13

Simpson, Stephen T. "Intervertebral Disc Disease." Veterinary Clinics of North America: Small Animal Practice 22, no. 4 (1992): 889–97. http://dx.doi.org/10.1016/s0195-5616(92)50081-x.

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14

Horak, Z., P. Tichy, J. Koukalova, and R. Sedlacek. "ARTIFICIAL INTERVERTEBRAL DISC." Journal of Biomechanics 40 (January 2007): S602. http://dx.doi.org/10.1016/s0021-9290(07)70590-0.

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15

Guyer, Richard D., and Donna D. Ohnmeiss. "Intervertebral Disc Prostheses." Spine 28, supplement (2003): S15—S23. http://dx.doi.org/10.1097/01.brs.0000076843.59883.e1.

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16

Anderson, Paul A., and Jeffrey P. Rouleau. "Intervertebral Disc Arthroplasty." Spine 29, no. 23 (2004): 2779–86. http://dx.doi.org/10.1097/01.brs.0000146460.11591.8a.

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17

Fraser, R. D., O. L. Osti, and B. Vernon-Roberts. "Intervertebral disc degeneration." European Spine Journal 1, no. 4 (1993): 205–13. http://dx.doi.org/10.1007/bf00298361.

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18

Noerma Kurniawa, Ceccare, Yeni Cahyati, and Rizki Agung Basuki. "PERBANDINGAN POSISI KNEE JOINT FLEKSI DAN EXTENSI PEMERIKSAAN LUMBOSACRAL ANTERO POSTERIOR (AP) SUPINE DALAM MEMPERLIHATKAN DISCUS INTERVERTEBRALIS." JRI (Jurnal Radiografer Indonesia) 3, no. 1 (2021): 13–19. http://dx.doi.org/10.55451/jri.v3i1.55.

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Background : Supine examination of lumbosacral antero posterior projection (AP) is used to obtain a clear lumbosacral radiograph, one of which shows an intervertebral disc. The objective the research was to determine the knee joint flexion position and knee joint extension position on the antero posterior lumbosacral (AP) Supine examination in the appearance of intervertebral discs.  Methods : Research of the position of the knee joint flexion and extension on the lumbosacral antero posterior (AP) Supine examination in displaying intervertebral discs, this is a comparative descriptive st

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19

Fernandez-Moure, Joseph, Caitlyn A. Moore, Keemberly Kim, et al. "Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy." SAGE Open Medicine 6 (January 1, 2018): 205031211876167. http://dx.doi.org/10.1177/2050312118761674.

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Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. Literature has made substantial progress in understanding the biological basis of intervertebral disc, which is reviewed here. Current medical and surgical management strategies have shortcomings that do not lend promise to be effective solutions in the coming years. With advances in understanding the cell biology and characteristics of the

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20

Zhang, Teng, Tonghao Wang та Baoshan Xu. "Polystyrene nanoparticles carrying miR-375 alleviate inflammatory response of intervertebral disc nucleus pulposus cells via NF-κB signaling pathway". Materials Express 12, № 6 (2022): 794–801. http://dx.doi.org/10.1166/mex.2022.2215.

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The aim of this study was to investigate the protective role of miR-375-loaded polystyrene nanoparticles (PSNPs) in inflammatory response within nucleus pulposus cells (NPC) in intervertebral disc. RT-qPCR was used to determine the miR-375 expression in the intervertebral disc NPCs and tissues from patients with inflammatory reaction. After transfection of PS-NPs carrying miR-375, MTT and flow cytometry experiment were conducted to assess proliferation, apoptosis and cell cycle of inflammatory cells in the intervertebral disc. The relationship between miR-375-loaded PS-NPs and NF-κB pathway wa

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21

Mitchell, Jeanette. "The intervertebral joints I: The intervertebral disc." South African Journal of Physiotherapy 47, no. 2 (1991): 34–36. http://dx.doi.org/10.4102/sajp.v47i2.762.

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The structure of the intervertebral disc is described in detail, some reference being made to clinically relevant aspects of the anatomy. Some biomechanical terms, such as motion and force, creep and hysteresis, are explained and discussed in relation to the intervertebral disc as a clinically important structure.

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22

MIKUCKYTĖ, Sandra, and Vytautas OSTAŠEVIČIUS. "Investigation of fluid flow velocity within the intervertebral disc." Mechanics 26, no. 6 (2020): 497–502. http://dx.doi.org/10.5755/j01.mech.26.6.25668.

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Enhancing fluid flow velocity within the intervertebral disc may allow to increase solute transportation rates and improve disc nutrition as the sufficient supply of the nutrients to cells of intervertebral disc is a key factor in order to avoid or delay processes of disc degeneration. Poroelastic finite element model of lumbar intervertebral disc is used to calculate fluid flow velocity with the intervertebral disc due to flexion, extension, lateral bending and axial rotation. When comparing the average of flow velocity, the highest values are calculated when flexion and extension moments wer

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23

Priymak, Maxim A., Alexei I. Gaivoronsky, Ivan V. Gaivoronsky, Gennadii I. Nichiporuk, Maria G. Gaivoronskaya, and Inga A. Goriacheva. "Lifetime morphological characteristics of the L<sub>IV</sub>-L<sub>V</sub> intervertebral disc in young and middle-aged adults." Bulletin of the Russian Military Medical Academy 24, no. 4 (2023): 689–96. http://dx.doi.org/10.17816/brmma110717.

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Morphoscopic and morphometric characteristics of the LIVLV intervertebral disc were assessed according to magnetic resonance images of the lumbar spine of 90 patients (66 men, 24 women). The morphometric parameters of the LIVLV intervertebral disc and nucleus pulposus were compared between young (1844 years old) and middle-aged (4560 years old) adults and in groups determined by sex and body type. In addition, morphoscopic characteristics, namely, the shape of the intervertebral disc and nucleus pulposus in the axial plane, were evaluated. Results. In normal intervertebral disc, LIVLV on the a

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24

Chabarova, Olga, Jelena Selivonec, and Alicia Menendez Hurtado. "Investigation of the Role of Osteoporotic Vertebra Degeneration on the Stability of the Lumbar Spine: In Silico Modelling under Compressive Loading." Bioengineering 11, no. 5 (2024): 507. http://dx.doi.org/10.3390/bioengineering11050507.

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An evaluation of the impact of osteoporosis on loss of spinal stability, with or without intervertebral disc degeneration, using computational analysis is presented. The research also investigates the correlation between osteoporosis and intervertebral disc degeneration. Three-dimensional finite element models of human lumbar spine segments were used to assess the influence of osteoporosis on spinal stability. Five different models of age-related degeneration were created using various material properties for trabecular bone and intervertebral discs. Calculation results indicate that in a spin

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25

Dheyaa Mousa, Ammar, and Ziad Shafeeq AlRawi. "Risk Factors for Lumbar Intervertebral Disc Herniation." International Journal of Science and Research (IJSR) 13, no. 12 (2024): 1560–68. https://doi.org/10.21275/sr241222232702.

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26

Swamy, A. "Material Selection for Modeling of Intervertebral Disc." International Journal of Scientific Engineering and Research 2, no. 4 (2014): 51–53. https://doi.org/10.70729/j2013240.

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27

Stepanov, Ivan A., and Vladimir A. Beloborodov. "A LONG-TERM OUTCOMES OF LUMBAR DISK ARTHROPLASTY AND LUMBAR INTERBODY FUSION IN SURGICAL TREATMENT OF LUMBAR INTERVERTEBRAL DISK DEGENERATIVE DISEASE: A SYSTEMATIC REVIEW." Baikal Medical Journal 3, no. 3 (2024): 39–47. http://dx.doi.org/10.57256/2949-0715-2024-3-39-47.

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Relevance. Patients with long-standing discogenic low back pain who do not show clinical improvement after conservative treatment are referred for surgical treatments such as lumbar fusion or total disc arthroplasty. The purpose –– to evaluate the long-term effectiveness and safety of total intervertebral disc arthroplasty (TDA) and lumbar interbody fusion (LIF) in patients with degenerative lumbar intervertebral disk disease. Material and methods. A comprehensive literature search strategy was developed in the PubMed/Medline and Cochrane Central Register of Randomized Controlled Trials databa

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28

Ding, Huaili, Lijun Liao, Peichun Yan, Xiaolin Zhao, and Min Li. "Three-Dimensional Finite Element Analysis of L4-5 Degenerative Lumbar Disc Traction under Different Pushing Heights." Journal of Healthcare Engineering 2021 (July 19, 2021): 1–9. http://dx.doi.org/10.1155/2021/1322397.

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Objective. To study and analyze the changes of intervertebral foramen height and area of the degenerative L4-5 intervertebral disc under different pushing heights by the finite element method. Methods. CT and MRI images of T12-S1 segments were obtained from a healthy volunteer who met the inclusion criteria. A DR machine was used to capture images of the lumbar lateral section before and after simultaneous pushing of the L4 and L5 spinous processes by manipulation called Daogaijinbei, and the measurement showed that the displacement changes of L4 and L5 were both approximately 10 cm, so the pu

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29

Ylinen, P., R. M. Tulamo, M. Kellomäki, P. Türmälä, P. Rokkanen, and T. Palmgren. "Lumbar intervertebral disc replacement using bioabsorbable self-reinforced poly-L-lactide full-threaded screws, or cylindrical implants of polylactide polymers, bioactive glass and Polyactive™." Veterinary and Comparative Orthopaedics and Traumatology 16, no. 03 (2003): 138–44. http://dx.doi.org/10.1055/s-0038-1632777.

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SummaryIntervertebral disc surgery leads to changes in the segmental anatomy and mobility, and subsequently to degenerative changes in the lumbar spine. Artificial intervertebral disc implants sufficient to replace the human lumbar intervertebral disc have been developed and the requirements for these defined. This is to our knowledge the first study on bioabsorbable intervertebral disc replacement implants. SR-PLLA screws, previously used in orthopaedic internal fixations, and cylindrical implants, specifially developed for this experimental preliminary study, were used to replace lumbar inte

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30

Allen, D. A., E. R. Schertel, M. D. Barnhart, et al. "Outcome and prognostic factors in nonambulatory Hansen Type I intervertebral disc extrusions: 308 cases." Veterinary and Comparative Orthopaedics and Traumatology 19, no. 01 (2006): 29–34. http://dx.doi.org/10.1055/s-0038-1632970.

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SummaryThoracolumbar intervertebral disc disease is the most common cause of caudal paresis in dogs (1). Whilst the pathogenesis of the extrusion has been widely studied, treatment protocols and prognostic factors relating to outcome remain controversial. Recent studies have examined a multitude of factors relating to time to regain ambulation after decompressive surgery. Most intervertebral disc herniations occur in the thoracolumbar region, causing upper motor neuron signs in the rear limbs, which are thought to have a more favourable prognosis compared to the lower motor neuron signs create

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31

Gonchigar, Uma, Taryn Cazzolli, Samon Tavakoli-Sabour, and Viktor Bartanusz. "A lumbar chondroma originating from the intervertebral disc." Surgical Neurology International 14 (February 24, 2023): 67. http://dx.doi.org/10.25259/sni_1171_2022.

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Background: Chondromas, benign cartilaginous primary bone tumors, seldom occur in the spine. Most spinal chondromas arise from the cartilaginous parts of the vertebra. Chondromas originating from the intervertebral disc are extraordinarily rare. Case Description: A 65-year-old female experienced recurrence of low back pain and left-sided lumbar radiculopathy after microdiscectomy and microdecompression. A mass continuous with the intervertebral disc was found to be compressing the left L3 nerve root and was resected. Histologic examination revealed a benign chondroma. Conclusion: Chondromas de

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32

Underberg, Julius, Arianna Maiolini, Maja Waschk, and Daniela Schweizer. "Extensive Epidural Hemorrhage Associated with Thoracolumbar Disc Extrusion in French Bulldogs." Veterinary Sciences 11, no. 11 (2024): 573. http://dx.doi.org/10.3390/vetsci11110573.

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(1) Background: Intervertebral disc extrusion may be accompanied by extensive epidural hemorrhage (EEH) and result in spinal cord compression. EEH is more commonly seen in French Bulldogs compared to other breeds. The majority of French Bulldogs have lumbar intervertebral disc extrusion, but it is unclear if there is an association between the site of thoracolumbar disc extrusion and EEH. This retrospective study’s aim was to investigate the association and prevalence between the site of thoracolumbar intervertebral disc extrusion and EEH in French Bulldogs. (2) Methods: Thoracolumbar MRI of F

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33

Maltseva, V. "Effect of Pb exposure on the cells and matrix of the intervertebral disc of rats." Regulatory Mechanisms in Biosystems 8, no. 2 (2017): 217–23. http://dx.doi.org/10.15421/021734.

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Degenerative spine diseases are common throughout the world. There are many factors that lead to these diseases. One of these exogenous factors may be Pb exposure. Most of the fundamental investigations about the negative effects of the Pb exposure have investigated the impact of high doses of Pb, while Pb exposure in low concentrations has been insufficiently studied. The nutrition of the intervertebral disc is provided by the vessels that grow into the vertebral bodies and the paravertebral tissue. This suggests the possibility that Pb penetrates from the bone to the intervertebral disc toge

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34

Zhang, Hua, Wei Li, YaoHong Wu, et al. "Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells." Stem Cells International 2022 (April 23, 2022): 1–15. http://dx.doi.org/10.1155/2022/1121064.

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The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine. However, the harsh microenvironment within the intervertebral disc is the main limitation of its regeneration. The osmolarity of the intervertebral disc is higher than that of other tissues, which has an important influence on the biological characteristics of NPMSCs. In this study, we observed the effect of different osmolarities on the biological characteristic

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35

Zhang, Jing, Wentao Zhang, Tianze Sun, et al. "The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells." Stem Cells International 2022 (November 7, 2022): 1–24. http://dx.doi.org/10.1155/2022/8671482.

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Intervertebral disc degeneration is the main cause of low back pain. Traditional treatment methods cannot repair degenerated intervertebral disc tissue. The emergence of stem cell therapy makes it possible to regenerate and repair degenerated intervertebral disc tissue. At present, mesenchymal stem cells are the most studied, and different types of mesenchymal stem cells have their own characteristics. However, due to the harsh and complex internal microenvironment of the intervertebral disc, it will affect the biological behaviors of the implanted mesenchymal stem cells, such as viability, pr

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36

Domanski, Janusz, Konstanty Skalski, Roman Grygoruk, and Adrian Mróz. "Rapid prototyping in the intervertebral implant design process." Rapid Prototyping Journal 21, no. 6 (2015): 735–46. http://dx.doi.org/10.1108/rpj-09-2013-0096.

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Purpose – The purpose of this paper is to present the methodology of a design process of new lumbar intervertebral disc implants with specific emphasis on the use of rapid prototyping technologies. The verification of functionality of artificial intervertebral discs is also given. The paper describes the attempt and preliminary research to evaluate the properties of the intervertebral disc implant prototypes manufactured with the use of different rapid prototyping technologies, i.e. FDM – fused deposition modelling, 3DP – 3D printing and SLM – selective laser melting. Design/methodology/approa

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37

Williams, Shawn P. "Regenerating of Intervertebral Disc." Physical Medicine, Rehabilitation & Disabilities 3, no. 2 (2017): 1–7. http://dx.doi.org/10.24966/pmrd-8670/100022.

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38

Cason, Garrick W., and Harry N. Herkowitz. "Cervical Intervertebral Disc Replacement." Journal of Bone and Joint Surgery-American Volume 95, no. 3 (2013): 279–85. http://dx.doi.org/10.2106/jbjs.j.01042.

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39

Haughton, Victor. "Imaging Intervertebral Disc Degeneration." Journal of Bone and Joint Surgery (American) 88, suppl_2 (2006): 15. http://dx.doi.org/10.2106/jbjs.f.00010.

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40

HAUGHTON, VICTOR. "IMAGING INTERVERTEBRAL DISC DEGENERATION." Journal of Bone and Joint Surgery-American Volume 88 (April 2006): 15–20. http://dx.doi.org/10.2106/00004623-200604002-00004.

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41

Blumenkopf, B. "Thoracic intervertebral disc herniations." Neurosurgery 23, no. 1 (1988): 36???40. http://dx.doi.org/10.1097/00006123-198807000-00008.

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42

Kuo, Ya-Wen, and Jaw-Lin Wang. "Rheology of Intervertebral Disc." Spine 35, no. 16 (2010): E743—E752. http://dx.doi.org/10.1097/brs.0b013e3181d7a839.

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43

Gruber, Helen, Edward Hanley, Kelly Leslie, and Jane Ingram. "Human intervertebral disc cells." Spine Journal 2, no. 5 (2002): 105–6. http://dx.doi.org/10.1016/s1529-9430(02)00230-9.

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44

Ricketson, Robert, James W. Simmons, and Bill O. Hauser. "The Prolapsed Intervertebral Disc." Spine 21, no. 23 (1996): 2758–62. http://dx.doi.org/10.1097/00007632-199612010-00010.

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45

Finkel, Howard Z. "Intraradicular, Intervertebral Disc Herniation." Spine 22, no. 9 (1997): 1028–29. http://dx.doi.org/10.1097/00007632-199705010-00017.

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46

JAFFRAY, DAVID, and JOHN P. OʼBRIEN. "Isolated Intervertebral Disc Resorption." Spine 11, no. 4 (1986): 397–401. http://dx.doi.org/10.1097/00007632-198605000-00020.

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47

Mellion, B. Theo, John P. Laurent, and William C. Watters. "Childhood intervertebral disc calcification." Child's Nervous System 9, no. 4 (1993): 233–38. http://dx.doi.org/10.1007/bf00303576.

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48

Czervionke, Leo F. "LUMBAR INTERVERTEBRAL DISC DISEASE." Neuroimaging Clinics of North America 3, no. 3 (1993): 465–85. https://doi.org/10.1016/s1052-5149(25)00177-7.

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49

Huddleston, P. "Cervical Intervertebral Disc Replacement." Yearbook of Orthopedics 2013 (2013): 84. https://doi.org/10.1016/j.yort.2013.04.015.

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50

Du, Yuxiang, Zhikun Wang, Yangming Wu, Chengyi Liu, and Lingli Zhang. "Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for Intervertebral Disc Regeneration." Stem Cells International 2021 (July 28, 2021): 1–12. http://dx.doi.org/10.1155/2021/2130727.

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Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back pain (LBP), which has become more prevalent from 21 century, causing an enormous economic burden for society. However, in spite of remarkable improvements in the basic research of IVD degeneration (IVDD), the effects of clinical treatments of IVDD are still leaving much to be desired. Accumulating evidence has proposed the existence of endogenous stem/progenitor cells in the IVD that possess the ability of proliferation and differentiation. However, few studies have reported the biological properties and

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