Relevant bibliographies by topics / Intestinal Perforation

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Intestinal Perforation'

Author: Grafiati
Published: 4 June 2021
Last updated: 21 June 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Intestinal Perforation.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Intestinal Perforation"

1

Donahue, Laura. "Spontaneous Intestinal Perforation." Neonatal Network 26, no. 5 (2007): 335–51. http://dx.doi.org/10.1891/0730-0832.26.5.335.

Full text
Abstract:
SPONTANEOUS INTESTINAL perforations (SIPs) have been documented to occur in as many as 8.4 percent of very low birth weight (VLBW) newborns.1Gastrointestinal (GI) perforations first appeared in the literature in 1825 when Siebold described a gastric perforation in an estimated 34-week-gestational-age infant.2Thelander in 1939 described the first cases of spontaneous perforation in three stillborn infants as perforations proximal to the ileocecal valve.3
APA, Harvard, Vancouver, ISO, and other styles
2

Hafsi, Montacer, Marwa Moussi, Asma Zouaghi, et al. "Intestinal incarceration following aspiration evacuation: A case report." Edorium Journal of Gynecology and Obstetrics 9, no. 1 (2024): 5–8. http://dx.doi.org/10.5348/100035g06mh2024cr.

Full text
Abstract:
Uterine perforation is a frequently overlooked complication of operative procedures. The incidence of perforation is estimated to range from 1 to 4 per 1000 during curettages for pregnancy termination. Reported complications include uterine, digestive, and vesical perforations, hemorrhage, endometritis, and secondary infertility. However, intestinal incarceration after uterine perforation remains extremely rare. We present a case of uterine perforation occurring after an aspiration curettage, complicated by digestive incarceration.
APA, Harvard, Vancouver, ISO, and other styles
3

Li, Zhi-Wang, Tao-Feng Jiang, Cheng-Kun Yang, Zhi-Jie Xu, Wen-Biao Zhu, and En Li. "Recurrent small intestinal perforation from gastric mucosal heterotopia: A case report." World Journal of Gastrointestinal Surgery 16, no. 12 (2024): 3857–61. http://dx.doi.org/10.4240/wjgs.v16.i12.3857.

Full text
Abstract:
BACKGROUND Gastric mucosal heterotopia (GMH) is a rare, typically asymptomatic condition characterized by ectopic gastric mucosa in tissues outside the stomach. However, it can lead to severe complications, including small intestinal perforation. This case report highlights the unique clinical presentation of GMH-induced recurrent small intestinal perforations, which has been rarely documented. These findings emphasize the importance of considering GMH in patients with unexplained recurrent gastrointestinal perforations. CASE SUMMARY A 13-year-old female presented with acute abdominal pain. Her medical history included four prior surgeries for small intestinal perforations. Enhanced computed tomography revealed localized bowel thickening and perforation, prompting emergency surgery. A 20 cm segment of the ileum was resected and anastomosed. Pathological analysis confirmed extensive GMH with ulceration and perforation, identifying GMH as the cause of the recurrent perforations. Postoperatively, the patient recovered well with no recurrence by the 10-month follow-up. CONCLUSION GMH should be considered in cases of recurrent unexplained intestinal perforations.
APA, Harvard, Vancouver, ISO, and other styles
4

Masood, Irfan, Zain Majid, Ali Rafiq, Waqas Rind, Aisha Zia, and Sajjad Raza. "Multiple, Pan-Enteric Perforation Secondary to Intestinal Tuberculosis." Case Reports in Surgery 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/318678.

Full text
Abstract:
Free perforation is one of the most feared complications of the intestinal tuberculosis. The terminal ileum is the most common site of perforation, while the majority of (90%) perforations are solitary. Herein, we describe a case of a 25-year-old male who presented with generalized peritonitis requiring an emergency exploratory laparotomy, which revealed pan-enteric perforation characterized by multiple perforations of the small bowel extending 10–15 cm from the DJ flexure up to the terminal ileum. The perforations were primarily closed, while 6–8 cm of the diseased terminal ileum was resected and the two ends were brought out as double-barreled ostomy. To the best of our knowledge, such an extensive tuberculous perforation of the small bowel has not been previously reported in the literature before.
APA, Harvard, Vancouver, ISO, and other styles
5

Olgemoeller, Franziska, Jonathan J. Waluza, Dalitso Zeka, et al. "Intestinal Perforations Associated With a High Mortality and Frequent Complications During an Epidemic of Multidrug-resistant Typhoid Fever in Blantyre, Malawi." Clinical Infectious Diseases 71, Supplement_2 (2020): S96—S101. http://dx.doi.org/10.1093/cid/ciaa405.

Full text
Abstract:
Abstract Background Typhoid fever remains a major source of morbidity and mortality in low-income settings. Its most feared complication is intestinal perforation. However, due to the paucity of diagnostic facilities in typhoid-endemic settings, including microbiology, histopathology, and radiology, the etiology of intestinal perforation is frequently assumed but rarely confirmed. This poses a challenge for accurately estimating burden of disease. Methods We recruited a prospective cohort of patients with confirmed intestinal perforation in 2016 and performed enhanced microbiological investigations (blood and tissue culture, plus tissue polymerase chain reaction [PCR] for Salmonella Typhi). In addition, we used a Poisson generalized linear model to estimate excess perforations attributed to the typhoid epidemic, using temporal trends in S. Typhi bloodstream infection and perforated abdominal viscus at Queen Elizabeth Central Hospital from 2008–2017. Results We recruited 23 patients with intraoperative findings consistent with intestinal perforation. 50% (11/22) of patients recruited were culture or PCR positive for S. Typhi. Case fatality rate from typhoid-associated intestinal perforation was substantial at 18% (2/11). Our statistical model estimates that culture-confirmed cases of typhoid fever lead to an excess of 0.046 perforations per clinical typhoid fever case (95% CI, .03–.06). We therefore estimate that typhoid fever accounts for 43% of all bowel perforation during the period of enhanced surveillance. Conclusions The morbidity and mortality associated with typhoid abdominal perforations are high. By placing clinical outcome data from a cohort in the context of longitudinal surgical registers and bacteremia data, we describe a valuable approach to adjusting estimates of the burden of typhoid fever.
APA, Harvard, Vancouver, ISO, and other styles
6

Torosian, M. H., and A. D. Turnbull. "Emergency laparotomy for spontaneous intestinal and colonic perforations in cancer patients receiving corticosteroids and chemotherapy." Journal of Clinical Oncology 6, no. 2 (1988): 291–96. http://dx.doi.org/10.1200/jco.1988.6.2.291.

Full text
Abstract:
Thirty patients with lymphoma (12), leukemia (two), myeloma (one), or metastatic solid tumors (15) were explored for 31 episodes of spontaneous intestinal perforation during an 11-year period at Memorial Sloan-Kettering Cancer Center. Twenty-three patients (76.6%) were receiving corticosteroids alone or in combination with chemotherapy and seven patients (23.4%) were receiving chemotherapy alone at the time of perforation. Fourteen perforations (45%) occurred in the small intestine and 17 perforations (55%) occurred in the colon. Malignancy was histologically demonstrated at the site of perforation in 16 patients (52%). Twenty major postoperative complications occurred in 15 patients (50%) and the operative mortality rate was 53%. Factors such as age, sex, duration or type of symptoms, site of perforation, malignancy at the site of perforation, peripheral leukocyte count, and serum albumin and total protein levels were not significantly related to patient survival. Early diagnosis and aggressive surgical intervention is essential to improve survival following intestinal perforation in this high-risk population.
APA, Harvard, Vancouver, ISO, and other styles
7

H. B., Shashikumar, Madhu B. S., and Shyama S. "Gastro intestinal perforations: an audit from a tertiary care teaching hospital, Mysore, India." International Surgery Journal 5, no. 11 (2018): 3484. http://dx.doi.org/10.18203/2349-2902.isj20184613.

Full text
Abstract:
Background: Peritonitis secondary to hollow viscus perforation is one of the most frequently encountered surgical emergencies in India. The objective of this study was to study the demographic and clinical profile of gastro intestinal perforations and surgical procedures done for the same in a tertiary care teaching hospital.Methods: This study was performed on 46 cases of hollow viscus perforation admitted in K. R. Hospital from January to June 2018. The presenting symptoms, age and sex profile, risk factors, site of perforation, the surgical procedure they underwent, post-operative complications were assessed and analyzed.Results: The most common age group affected was 21-30 years out of which 89.1 % were males. Gastric perforations were the most common type (56.5%) and jejunal perforations were the least common (6.5%). Abdominal pain was the main presenting symptom in all the cases. Fever was found to be a significant history in cases of ileal perforation (p=0.001) as was history of trauma in cases of jejunal perforation (p=0.001). Guarding, rigidity and air under the diaphragm were seen consistently in most cases. Graham’s patch repair was the most common surgical procedure performed. Ileostomy was the most common surgery done for ileal perforations. Wound infections were the most common post-operative complication observed and death occurred in 13% of cases mostly due to sepsis and cardio pulmonary complications.Conclusions: This study showed an increased incidence of perforation in younger age group which is alarming. The rise in the frequency of gastric perforations points towards an unhealthy lifestyle and dietary habits.
APA, Harvard, Vancouver, ISO, and other styles
8

Nicolodi, Gabriel Cleve, Cesar Rodrigo Trippia, Maria Fernanda F. S. Caboclo, et al. "Intestinal perforation by an ingested foreign body." Radiologia Brasileira 49, no. 5 (2016): 295–99. http://dx.doi.org/10.1590/0100-3984.2015.0127.

Full text
Abstract:
Abstract Objective: To identify the computed tomography findings suggestive of intestinal perforation by an ingested foreign body. Materials and Methods: This was a retrospective study of four cases of surgically proven intestinal perforation by a foreign body, comparing the computed tomography findings with those described in the literature. Results: None of the patients reported having ingested a foreign body, all were over 60 years of age, three of the four patients used a dental prosthesis, and all of the foreign bodies were elongated and sharp. In all four patients, there were findings indicative of acute abdomen. None of the foreign bodies were identified on conventional X-rays. The computed tomography findings suggestive of perforation were thickening of the intestinal walls (in all four cases), increased density of mesenteric fat (in all four cases), identification of the foreign body passing through the intestinal wall (in three cases), and gas in the peritoneal cavity (in one case). Conclusion: In cases of foreign body ingestion, intestinal perforation is more common when the foreign body is elongated and sharp. Although patients typically do not report having ingested such foreign bodies, the scenario should be suspected in elderly individuals who use dental prostheses. A computed tomography scan can detect foreign bodies, locate perforations, and guide treatment. The findings that suggest perforation are thickening of the intestinal walls, increased mesenteric fat density, and, less frequently, gas in the peritoneal cavity, often restricted to the point of perforation.
APA, Harvard, Vancouver, ISO, and other styles
9

Lipatov, V. A., V. P. Gavrilyuk, D. A. Severinov, and O. V. Padalkina. "Simulation of intestinal perforation in experiment." Experimental and Clinical Gastroenterology, no. 6 (October 22, 2024): 139–44. http://dx.doi.org/10.31146/1682-8658-ecg-226-6-139-144.

Full text
Abstract:
The current problem of neonatal and pediatric surgery remains the tactics of surgical treatment and postoperative management of patients with perforated peritonitis. Mortality with perforation of the stomach and intestines in children in the newborn period reaches about 40-80 %. The combination of the syndrome of increased intra-abdominal pressure and multiple organ failure causes the extremely serious condition of patients. In this connection, new approaches to the surgical treatment of such patients are currently being actively developed. For this, new medical devices are tested in experimental practice, but the problem of such studies, first of all, lies in the lack of an adequate model of the pathological process. The aim of the work is to analyze the methods of experimental modeling of intestinal perforations described in the public domain. For this, a study was conducted of the most significant scientific publications of such databases as Google Scholar, PubMed, Scopus, eLIBRARY. The present work provides a detailed description of existing options for modeling perforations of various parts of the gastrointestinal tract (stomach, small intestine and colon), depending on the goals of the experiment. Several rather rare techniques based on the introduction of microorganisms are also presented. In addition, the article describes the method proposed by the authors for modeling perforation using laparoscopic access.
APA, Harvard, Vancouver, ISO, and other styles
10

Abhishek, Jain, Jain Trilok, Kumar Badaya Dinesh, and Jain Vinita. "Assessment of the Surgical Profile among Patients of Gastro-Intestinal Tract Perforation." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 786–89. https://doi.org/10.5281/zenodo.11221453.

Full text
Abstract:
Background: Gastrointestinal tract perforation occurs when pathology of any specific disease involves the entire depth of the gastrointestinal tract. Gastrointestinal tract perforation leads to the contamination of peritoneal cavity with intestinal contents. According to previous researches it was reported that perforations can be occurred anywhere in full length of gastrointestinal tract. Material & Methods: Patients who were diagnosed as perforation and peritonitis on the basis of laboratory diagnosis and clinical examination were enrolled by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant. Results: In the present study, out of total study participants abdominal pain was the most common presenting symptom present in patients which was followed by fever, abdominal distension and vomiting. On the basis of time of perforation, 10% cases presented within12 hour, between 12 and 24 hour was reported among in 50% cases, in the rage of 24 and 48 hour seen in 20% patients, in the range of 48 and 72 hour reported in 10% cases, in range of 72 and 96 hour reported in10% cases. Near about all patients were operated in the range of 12 hours of hospitalization. We found that majority of cases had circular perforation of typhoid at antimesenteric border which was followed by tubercular elliptical perforation on the antimesenteric border and traumatic type perforation. Conclusion: The most common presenting symptoms present among patients were abdominal pain, abdominal distension, vomiting, fever and obstipation. We found that majority of cases had circular perforation of typhoid at an times enteric border which was followed by tubercular elliptical perforation on the antimesenteric border and traumatic type perforation. Keywords: Gastro-intestinal tract perforation, signs and symptoms, presentation.    
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Intestinal Perforation"

1

Pires, Sara Duarte Sequeira. "Peritonite secundária a perfuração intestinal por ingestão de corpo estranho em canídeos : a propósito de quatro casos clínicos." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11427.

Full text
Abstract:
Dissertação de Mestrado Integrado em Medicina Veterinária<br>A realização deste trabalho baseia-se em quatro casos clínicos de peritonite secundária a perfuração intestinal por ingestão de corpo estranho. Este é um processo infecioso, no qual a contaminação da cavidade peritoneal leva à libertação de substâncias vasoativas e ao aumento da permeabilidade vascular, o que predispõe a uma situação de hipovolémia e choque sético. O diagnóstico é realizado sobretudo com o recurso à imagiologia (radiografia e ecografia) e análise do líquido peritoneal. É importante a realização de análises sanguíneas para avaliar o estado do animal e corrigir eventuais desequilíbrios. A abordagem passa pelo tratamento pré-cirúrgico de forma a estabilizar a hipovolémia, os desequilíbrios ácido-base e eletrolíticos, assim como, pela correção cirúrgica da fonte de contaminação peritoneal. As particularidades da abordagem cirúrgica variam entre autores e consoante a situação clínica concreta do paciente. No pós-cirúrgico podem surgir algumas complicações associadas à doença em si, à técnica cirúrgica utilizada ou a fatores intrínsecos ao paciente. Geralmente o prognóstico é reservado e as taxas de mortalidade são elevadas.<br>ABSTRACT - Secondary peritonitis in dogs due to bowel perforation because of ingestion of foreign bodies – presentation of four clinical cases - This document is based in four clinical cases of secondary peritonitis due to bowel perforation because of ingestion of foreign bodies. The related inflammation releases vasoactive substances and that leads to the increase of vascular permeability and consequently to hypovolemia and septic shock. The diagnosis is based in imaging tests (radiology and ultrasound) and in peritoneal fluid analysis. Blood analyses are important to evaluate the animal’s clinical status and correct imbalances. First the hypovolemia, the electrolytic and acid-basic imbalances should be corrected. Then a surgical treatment is necessary to correct the source of contamination. There are some differences in the surgical technique depending on the surgeon choice and to the animal’s clinical status. After the surgery some complications could be present associated with the disease, due to the surgical technique or because of the animal’s intrinsic factors. In general the prognosis is guarded and there is a high mortality rate.
APA, Harvard, Vancouver, ISO, and other styles
2

Tarnowietzki, Evelyne [Verfasser]. "Die Rolle von HIF-1alpha in der Pathogenese der nekrotisierenden Enterokolitits und fokaler intestinaler Perforation bei Frühgeborenen / Evelyne Tarnowietzki." Ulm : Universität Ulm, 2020. http://d-nb.info/1223986020/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tarnowietzki, Evelyne Diana [Verfasser]. "Die Rolle von HIF-1alpha in der Pathogenese der nekrotisierenden Enterokolitits und fokaler intestinaler Perforation bei Frühgeborenen / Evelyne Tarnowietzki." Ulm : Universität Ulm, 2020. http://d-nb.info/1223986020/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gerwien, Marina [Verfasser], and Klaus-Dieter [Akademischer Betreuer] Rückauer. "Nekrotisierende Enterocolitis : Literaturübersichtsarbeit bezüglich der Nekrotisierenden Enterocolitis (NEK) sowie Deskription eines Patientenkollektivs mit NEK oder Fokaler Intestinaler Perforation (FIP) unter besonderer Berücksichtigung prognostisch relevanter Faktoren." Freiburg : Universität, 2012. http://d-nb.info/1114887374/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

"Necrotizing enterocolitis versus spontaneous intestinal perforation in high risk neonates: comparative investigations of plasma profiles of immunoregulatory proteins and specific expressions in intestinal tissues." 2011. http://library.cuhk.edu.hk/record=b5894836.

Full text
Abstract:
Leung, Wan Lun Fiona.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 179-204).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>中文摘要 --- p.v<br>Acknowledgement --- p.viii<br>List of Abbreviations and Symbols x --- p.vi<br>List of Tables --- p.xx<br>List of Figures --- p.xxi<br>Chapter CHAPTER ONE --- Introduction --- p.1<br>Chapter 1.1 --- General Overview --- p.1<br>Chapter 1.2 --- Necrotizing Enterocolitis (NEC) --- p.3<br>Chapter 1.2.1 --- Epidemiology of NEC --- p.3<br>Chapter 1.2.2 --- "Clinical Presentation, Diagnosis and Management of NEC" --- p.5<br>Chapter 1.2.3 --- Pathophysiology of NEC --- p.9<br>Chapter 1.2.3.1 --- Prematurity --- p.9<br>Chapter 1.2.3.2 --- Bacterial Colonization --- p.12<br>Chapter 1.2.3.3 --- Enteral Feeding --- p.15<br>Chapter 1.2.3.4 --- Hypoxia and Ischemia --- p.16<br>Chapter 1.2.3.5 --- Genetic Polymorphism --- p.17<br>Chapter 1.2.3.6 --- Inflammatory Mediators --- p.20<br>Chapter 1.3 --- Spontaneous Intestinal Perforation (SIP) --- p.24<br>Chapter 1.3.1 --- Epidemiology of SIP --- p.24<br>Chapter 1.3.2 --- "Clinical Presentation, Diagnosis and Management of SIP" --- p.26<br>Chapter 1.3.3 --- Risk Factors of SIP --- p.28<br>Chapter 1.3.3.1 --- Prematurity --- p.29<br>Chapter 1.3.3.2 --- Use of Drugs --- p.30<br>Chapter 1.4 --- Comparison between NEC and SIP --- p.32<br>Chapter 1.5 --- Role of Cytokines in Pathogenesis of NEC and SIP --- p.38<br>Chapter 1.6 --- Immunoregulatory Molecules of Interest in This Study --- p.46<br>Chapter 1.6.1 --- Angiopoietin-2 (Ang-2) --- p.46<br>Chapter 1.6.2 --- v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2 (avian) (ErbB3) --- p.48<br>Chapter 1.6.3 --- Type II Interleukin-1 Receptor (IL-1RII) --- p.52<br>Chapter 1.6.4 --- Urokinase Plasminogen Activator Receptor (uPAR) --- p.54<br>Chapter CHAPTER TWO --- Objectives --- p.57<br>Chapter CHAPTER THREE --- Materials and Methodology --- p.58<br>Chapter 3.1 --- Overview of the Experimental Procedures --- p.58<br>Chapter 3.1.1 --- Investigation on the Profile of Circulatory Immunoregulatory Proteins in Plasma of NEC and SIP High Risk Neonates --- p.58<br>Chapter 3.1.2 --- Investigation on the mRNA Expression Level of Targeted Immunoregulatory Molecules on Resected Intestinal Tissues in NEC and SIP Neonates --- p.58<br>Chapter 3.1.3 --- Investigation on the mRNA and Protein Expression Levels of Targeted Immunoregulatory Molecules in Human Intestinal Cell Lines --- p.60<br>Chapter 3.2 --- Reagents and Lab-wares with Their Sources --- p.61<br>Chapter 3.3 --- Study Population --- p.63<br>Chapter 3.4 --- Collection of Neonatal Whole Blood Samples --- p.65<br>Chapter 3.5 --- Cytokine Antibody Array Analyses --- p.67<br>Chapter 3.6 --- Enzyme-linked Immunosorbant Assays (ELISA) --- p.69<br>Chapter 3.6.1 --- Angiopoietin-2 --- p.69<br>Chapter 3.6.2 --- sErbB3 --- p.71<br>Chapter 3.6.3 --- sIL-lRII --- p.72<br>Chapter 3.6.4 --- suPAR --- p.74<br>Chapter 3.7 --- Collection of Neonatal Resected Intestinal Tissues --- p.76<br>Chapter 3.8 --- Resected Intestinal Tissue RNA Isolation --- p.78<br>Chapter 3.9 --- Purity Assessment of the Purified Tissue RNA Samples --- p.80<br>Chapter 3.10 --- Integrity Assessment of the Purified Tissue RNA Samples --- p.81<br>Chapter 3.11 --- In vitro Stimulation of Human Enterocytes by Lipopolysaccharides (LPS) and/or Platelet Activating Factor (PAF) --- p.84<br>Chapter 3.12 --- mRNA Expression Level Assessment of Selected Target Genes in Resected Intestinal Tissues and Human Intestinal Cell Lines --- p.86<br>Chapter 3.12.1 --- Synthesis of First Strand cDNA --- p.86<br>Chapter 3.12.2 --- Quantitative Polymerase Chain Reaction (qPCR) --- p.87<br>Chapter 3.13 --- Statistical Analysis --- p.89<br>Chapter CHAPTER FOUR --- Screening of Immunoregulatory Target Protein Molecules in Plasma of NEC and SIP Patients by Cytokine Array Analyses --- p.104<br>Chapter 4.1 --- Results --- p.104<br>Chapter 4.1.1 --- Screening of Detectable Immunoregulatory Target Molecules --- p.104<br>Chapter 4.1.2 --- Selection of Target Molecules Based on the Fold Change in NEC or SIP Compared with Control Samples --- p.105<br>Chapter 4.1.2.1 --- Similar Regulation of Target Molecules in Both NEC and SIP patients --- p.105<br>Chapter 4.1.2.2 --- Differential regulation of Target Molecules in NEC and SIP Patients --- p.106<br>Chapter 4.1.2.3 --- "Relative Normalized Expressions of Selected Circulatory Immunoregulatory Protein Molecules in NEC, SIP and Control Neonates" --- p.108<br>Chapter 4.1.2.3.1 --- Anti-inflammation --- p.108<br>Chapter 4.1.2.3.2 --- Pro-inflammation --- p.109<br>Chapter 4.1.2.3.3 --- Cell Growth --- p.110<br>Chapter 4.1.2.3.4 --- Wound Healing --- p.110<br>Chapter 4.1.2.3.5 --- Angiogenesis --- p.111<br>Chapter 4.1.2.3.6 --- "Anti-apoptosis, Cell Adhesion and Extracellular Matrix Organization" --- p.112<br>Chapter 4.1.3 --- Further Selection of Novel Target Molecules Based on Statistical Significance and Fold Change of NEC versus SIP --- p.113<br>Chapter 4.2 --- Discussion --- p.115<br>Chapter CHAPTER FIVE --- Validation of Target Proteins in Plasma of NEC and SIP Patients by Enzyme-linked Immunosorbant Assay --- p.132<br>Chapter 5.1 --- Results --- p.133<br>Chapter 5.1.1 --- Demographic Data of the Study Group --- p.133<br>Chapter 5.1.2 --- "Comparison of Plasma Levels of Target Proteins between NEC, SIP and Respective Controls" --- p.134<br>Chapter 5.1.3 --- Longitudinal Study of the Pre- and Post-operative Target Proteins Levels in Plasma --- p.136<br>Chapter 5.2 --- Discussion --- p.138<br>Chapter CHAPTER SIX --- Investigation on mRNA Expression Levels of Target Immunoregulatory Protein Molecules in Intestinal Tissue and Intestinal Cell Lines --- p.151<br>Chapter 6.1 --- Results --- p.152<br>Chapter 6.1.1 --- mRNA Expression Levels of Target Molecules in the Diseased Margin of Resected Intestinal Tissues of NEC and SIP patients --- p.152<br>Chapter 6.1.2 --- mRNA Expression Levels of Target Molecules in the Macroscopically Normal and Diseased Margin of Resected Intestinal Tissues of NEC and SIP patients --- p.154<br>Chapter 6.1.3 --- mRNA Expression Levels of Target Molecules in Human Intestinal Cell Lines upon LPS and PAF Challenge --- p.156<br>Chapter 6.1.3.1 --- FHs-74 Int Cell Line --- p.156<br>Chapter 6.1.3.2 --- Caco-2 Cell Line --- p.157<br>Chapter 6.2 --- Discussion --- p.158<br>Chapter CHAPTER SEVEN --- General Discussion --- p.171<br>Chapter 7.1 --- Overall Findings --- p.171<br>Chapter 7.2 --- Limitations of Study --- p.174<br>Chapter 7.3 --- Future Investigations --- p.177<br>References --- p.179
APA, Harvard, Vancouver, ISO, and other styles
6

Hein, Vicky. "Nekrotisierende Enterokolitis und Fokale Intestinale Perforation." 2020. https://ul.qucosa.de/id/qucosa%3A73262.

Full text
Abstract:
Die Nekrotisierende Enterokolitis (NEK) und die Fokale Intestinale Perforation (FIP) sind schwere Erkrankungen, die in den ersten Lebenswochen von Frühgeborenen auftreten können und durch den Grad der Unreife (niedriges Gestationsalter und Geburtsgewicht) gefördert werden. Als weitere Einflussfaktoren werden insbesondere die Ernährung, Medikamente (prä- und postnatale Steroide, Antibiotika, H2-Blocker, Morphin, Indometacin, Ibuprofen) sowie perinatale Faktoren (Tokolyse, vorzeitiger Blasensprung, AIS und andere Infektionen der Mutter) kontrovers diskutiert. Diese Variablen und das resultierende Outcome wurden anhand der am UKL im Zeitraum von Januar 2008 bis Dezember 2014 geborenen Frühgeborenen mit einem Geburtsgewicht von unter 750 g retrospektiv untersucht. In die Analyse eingeschlossen wurden 168 Kinder, von denen 21 Kinder (12,5 %) eine NEK und 9 Kinder (5,4 %) eine FIP entwickelten. Die Analyse der Einflussfaktoren auf die Kinder und ihr weiteres Leben wurde in die Analyse der Gesamtpopulation (alle 138 gesunden Kinder gegenüber den 30 erkrankten Kindern), sowie mehrere Subpopulationen (alle vor der vollendeten 25. SSW geborenen Kinder und ein Vergleich der an NEK mit den an FIP erkrankten Kindern) aufgeteilt. Ein niedriges Geburtsgewicht sowie ein jüngeres Gestationsalter zur Geburt sind entscheidende Einflussfaktoren auf die untersuchten Erkrankungen. Ebenso zeigt sich ein vermehrtes Auftreten von NEK/FIP bei niedrigem Nabelschnur-pH-Wert (Mittelwert NEK/FIP: 7,22; Mittelwert gesund: 7,28), niedrigem Hämatokritwert (Mittelwert NEK/FIP: 40,5; Mittelwert gesund: 46,4), schlechter respiratorischer Situation sowie Ibuprofen- und Opioideinsatz. Kein Einfluss ließ sich durch die pränatale Steroidgabe, ein AIS, den Einsatz von Tokolyse, einen vorzeitigen Blasensprung, den Apgar-Wert sowie durch eine Pantoprazol- oder Antibiotikaverabreichung nachweisen. Erkrankte Kinder hatten eine um 7 % erhöhte Mortalität, verbrachten eine längere Zeit im Krankenhaus (im Schnitt 36 Tage länger), hatten ein höheres Entlassungsgewicht (rund 630 g mehr) und wurden erst später voll enteral ernährt (im Mittel 21 Tage später) als nicht erkrankte Kinder. Die erste Fütterung erhielten die später erkrankten Kinder 6 Stunden später als Kinder, die nicht erkrankten. Ebenso erhielten die später an einer NEK/FIP erkrankten Kinder länger Glucose, bevor sie Frauenmilch gefüttert bekamen und schieden seltener aus (Stuhlgang und Erbrechen/Spucken). Der Einsatz postnataler Steroide hatte einen Einfluss auf die Auftretenswahrscheinlichkeit einer FIP (67 %), aber nicht einer NEK (19 %). Weitere Studien zur klareren Differenzierung der neu gefundenen Faktoren Nabelschnur-pH-Wert und Hämatokritwert sind nötig, um die Erkrankungen gegebenenfalls früher zu erkennen, entsprechend zu therapieren und damit die Mortalität zu reduzieren. Die vorliegenden Daten verdeutlichen, dass die FIP und die NEK im Hinblick auf das klinische Management zusammen analysiert werden können.
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Intestinal Perforation"

1

Hylton, Jared, and Sarah Deverman. Necrotizing Enterocolitis. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0001.

Full text
Abstract:
Necrotizing enterocolitis (NEC) is a potentially life-threatening condition that affects mainly preterm infants. It is one of the most common surgical emergencies in the neonatal intensive care unit. While medical management is the first line of treatment, if that fails, NEC becomes a surgical emergency, and the pediatric anesthesiologist must be prepared. This chapter covers the pathogenesis, risk factors, clinical presentation and diagnosis, prevention, medical and surgical management, pre- and intraoperative anesthetic assessment, and postoperative management of NEC. Topics covered include intestinal perforation, necrotizing enterocolitis, neonatal anesthesia, pneumatosis intestinalis, prematurity, and ventilatory management. The chapter ends with review questions on the chapter’s content.
APA, Harvard, Vancouver, ISO, and other styles
2

Puntis, John. Necrotizing enterocolitis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0007.

Full text
Abstract:
Necrotizing enterocolitis is a common and serous disease predominantly affecting premature newborns, with an incidence, morbidity, and mortality that has remained unchanged for several decades. Around 7% of infants between 500g and 1500g birth weight are affected, with the disease often manifesting with vomiting, bilious aspirates, distended abdomen, and blood in stools around 8–10 days of age. Medical management includes decompression of the gastrointestinal tract via a nasogastric tube, broad-spectrum antibiotics, and bowel ‘rest’ (total parenteral nutrition). Surgical intervention is required for intestinal perforation or ongoing deterioration despite medical management. The pathogenesis is multifactorial and includes genetic predisposition, gastrointestinal immaturity, imbalance in microvascular tone, abnormal intestinal microbiological colonization, and a highly immunoreactive intestinal mucosa. Breast milk feeds appear to confer some degree of protection.
APA, Harvard, Vancouver, ISO, and other styles
3

Fraser, Britt. Acute Fluid Resuscitation for Intussusception. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0004.

Full text
Abstract:
Intussusception occurs when a proximal section of bowel invaginates into more distal bowel and is then advanced by peristalsis. It is the most common cause of intestinal obstruction in infants, and untreated can lead to bowel ischemia and perforation. Early recognition and treatment can prevent the need for surgical intervention and complications. Intussusception can also result in significant dehydration due to vomiting and diarrhea. An essential aspect of the perioperative management is to identify and treat dehydration.
APA, Harvard, Vancouver, ISO, and other styles
4

Stevens, Philip, and Paul Dark. Ileus and obstruction in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0182.

Full text
Abstract:
Obstruction is the commonest cause of acute intestinal failure in critical care. Management is dependent upon whether it is adynamic or mechanical in origin. Paralytic ileus is managed conservatively by correction of electrolyte disturbances, nutritional support, and minimization of enterostatic drug use. Pharmacological agents aimed at reducing sympathetic stimuli may be useful, although widespread application is limited due to anti-muscarinic side effects. Peripherally acting μ‎-opioid receptor antagonists, may have a role, although data in critical illness are lacking. Prokinetic agents have not been shown to reduce ileus in clinical trials. Colonoscopic decompression may be required when conservative management fails. Rarely, surgical decompression becomes necessary if ileus arises in the context of abdominal compartment syndrome. Mechanical obstruction is more likely to require surgery, although adhesional obstruction, responsible for 80% of small bowel obstruction, may settle within 7 days of conservative management. Large bowel obstruction is more commonly due to tumours, diverticular stricture, or volvulus, and more likely to require endoscopic or surgical intervention. The hallmark of obstruction is colic, characterized by an inability to settle, in contrast to the peritonitic patient who lies completely still. Peritonitis in the presence of obstruction indicates possible perforation or necrosis for which urgent operative intervention is required. Clinical features may be absent in sedated patients hence the index of suspicion should remain high in any critically-ill patient intolerant of enteral feeding.
APA, Harvard, Vancouver, ISO, and other styles
5

PEDARRE-E. Etude du traitement chirurgical de la perforation intestinale au cours de la fièvre typhoïde. Hachette Livre - BNF, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

White, Maddie. Colorectal and lower gastrointestinal surgery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642663.003.0019.

Full text
Abstract:
The lower gastrointestinal tract includes most of the small intestine and all of the large intestine. The patient presenting with an acute abdomen may have a bowel obstruction which could lead to ischaemia and perforation. Thorough assessment and close observation are imperative, because, if surgical intervention is indicated, this needs to be performed promptly. This chapter provides an overview of inflammatory bowel disorders, tumours, hernias, obstructions, the acute abdomen, ischaemic bowel, complications of bowel surgery, and stomas.
APA, Harvard, Vancouver, ISO, and other styles
7

Symptômes du Cancer Colorectal: Saignement Rectal, Douleur Abdominale, Changements Dans les Selles, Perte de Poids, Fatigue, Ballonnements, anémie, Satiété Précoce, Sentiment de Selles Incomplètes, Obstruction Ou Perforation Intestinale. Independently Published, 2021.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Keshav, Satish, and Alexandra Kent. Inflammatory bowel disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0203.

Full text
Abstract:
Inflammatory bowel disease (IBD) encompasses ulcerative colitis (UC) and Crohn’s disease (CD). Both conditions cause chronic relapsing inflammation in the gastrointestinal (GI) tract, but have different characteristics. UC causes diffuse mucosal inflammation limited to the colon, extending proximally from the anal verge, with the rectum involved in 95% of patients. UC is described in terms of the disease extent: proctitis (confined to the rectum), proctosigmoiditis (disease confined to the recto-sigmoid colon), distal disease (distal to the splenic flexure), and pan-colitis (the entire large intestine). The extent of disease can change, with proximal extension seen in approximately a third of patients with proctitis, although there is great variation between studies. CD causes inflammation that can affect the entire thickness of the wall of the intestine, and is not confined to the mucosa. CD can affect any part of the GI tract. The terminal ileum is affected in approximately 80% of cases, the colon in approximately 60% of cases, and the rectum and perianal region in approximately 40% of cases. CD is classified by location (ileal, colonic, ileocolonic, upper GI tract), by the presence of stricturing or penetrating disease, and by the age of onset (before or after the age of 40). Penetrating disease refers to the development of fistulae, which can lead to complications such as abscesses or perforations. An earlier age at onset is associated with more complicated disease. The diagnosis of UC or CD is established through a combination of clinical, endoscopic, radiological, and histological criteria rather than by any single modality. Occasionally, it is not possible to establish an unequivocal diagnosis of CD or UC in IBD, and a third category, accounting for nearly 10% of cases, is used, termed IBD unclassified.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Intestinal Perforation"

1

Shao, Yen-Chen, Ming-Yin Shen, and William Tzu-Liang Chen. "Laparoscopic Hartmann’s Procedure." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_23.

Full text
Abstract:
AbstractHartmann’s procedure, Hartmann’s resection, or Hartmann’s operation is the surgical resection consisting of sigmoidectomy without intestinal restoration. It contains an end-colostomy and closure of a rectal stump. It was first described by Henri Albert Hartmann (1860–1952) for resection of rectal or sigmoid cancer [1]. Nowadays, Hartmann procedure is usually used in treating malignant obstruction of left-sided colon or in emergent conditions, such as sigmoid colon perforation [2], mostly because of diverticulum disease. The advantage of Hartmann’s procedure is reduction in morbidity and mortality in emergent settings because it avoids the possibility of complications from a colorectal anastomosis. For patients with unstable hemodynamic status, or multiple comorbidity or inflammatory condition of the intestinal tissue, which would make performing a colorectal anastomosis difficult or have a higher risk of anastomotic leakage, this procedure is simple and fast, and meanwhile preserve the chance of restoration of intestine continuity after patients’ general condition got improvement. However, the Hartmann reversal rate is variable in different studies, ranging from 0 to 50% [3, 4]. The morbidity rate of Hartmann reversal is up to 55%, and the mortality rate is ranging from 0 to 14% [5–7]. A study showed reversal of Hartmann between 3 and 9 months associated with increased risk of postoperative complications [8]. The mean interval from Hartmann procedure to its reversal is ranging from 7.5 to 9.1 months [3, 5]. We usually delay the reversal of Hartmann’s operation at least 6 months later in our daily practice. Hartmann’s procedure and/or reversal of Hartmann’s procedure could be conventional or laparoscopic. Laparoscopic reversal of Hartmann’s procedure is associated with less complications compared to the conventional method, especially in wound infection, anastomotic leakage, and cardiopulmonary complications [3].
APA, Harvard, Vancouver, ISO, and other styles
2

Vishnu Priya, M., Touzeen Hussain, G. Muthukumaran, and P. Tarun Varma. "Fish Bone-Induced Intestinal Perforation Complicated by Superior Mesenteric Artery Thrombosis —A Case Report." In Recent Developments in Microbiology, Biotechnology and Pharmaceutical Sciences. CRC Press, 2025. https://doi.org/10.1201/9781003618140-36.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Gordon, Phillip V., Jonathan R. Swanson, and Reese H. Clark. "Spontaneous Intestinal Perforation (SIP) is not Necrotizing Enterocolitis (NEC) But Remains the Major Confounder of NEC Data." In Necrotizing Enterocolitis. CRC Press, 2021. http://dx.doi.org/10.1201/9780429288302-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

"Malignant Intestinal Perforation." In Pocket Guide to Oncologic Emergencies. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781009052900.031.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pipal, Dharmendra Kumar, Vijay Verma, Saurabh Kothari, Vibha R. Pipal, and Latika Sharma. "Typhoid Intestinal Perforation: A Management Perspective." In Advanced Concepts in Medicine and Medical Research Vol. 5. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/acmmr/v5/6833e.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ghoda, Manoj. "Recurrent Dimness of Vision and Intestinal Perforation." In Bedtime Gastroenterology. Jaypee Brothers Medical Publishers (P) Ltd., 2007. http://dx.doi.org/10.5005/jp/books/10090_55.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Ghoda, Manoj. "Case-55 Recurrent Dimness of Vision and Intestinal Perforation." In Textbook of Biochemistry for Medical Students. Jaypee Brothers Medical Publishers (P) Ltd., 2007. http://dx.doi.org/10.5005/jp/books/10897_55.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

"Upper gastrointestinal surgery." In Oxford Handbook of Clinical Surgery, edited by Greg McLatchie, Neil Borley, Anil Agarwal, Santhini Jeyarajah, Rhiannon Harris, and Ruwan Weerakkody. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198799481.003.0008.

Full text
Abstract:
This chapter outlines the assessment and management of the patient who presents with dysphagia, haematemesis and upper gastrointestinal perforation. The conditions commonly affecting the oesophagus, stomach, duodenum, jejunum and ileum are described; oesophageal motility disorders, pharyngeal pouch, hiatus hernia, gastro-oesphageal reflux disease, oesophageal tumours, peptic ulcer disease, gastric tumours, chronic intestinal ischaemia and small bowel tumours. Procedures such as upper gastrointestinal endoscopy and surgery for morbid obesity are also discussed in this chapter.
APA, Harvard, Vancouver, ISO, and other styles
9

Reynolds, Maegan S., Yamini Jadcherla, and Esben Vogelius. "What’s That in the Diaper?" In Pediatric Emergency Radiology. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197628553.003.0004.

Full text
Abstract:
Abstract Bloody stools in a neonate can be from a variety of etiologies such as benign anal fissures or milk protein allergy, or from more life-threatening etiologies such as volvulus, infectious colitis, or necrotizing enterocolitis (NEC). Older children may have bloody stools associated with intussusception, usually diagnosed with ultrasound, and treated with contrast enema or Meckel’s diverticulum diagnosed with a technetium scintigraphy. NEC is most commonly seen in premature infants but must be excluded in infants presenting to the Emergency Department with bloody stools. An abdominal radiograph is the initial imaging modality of choice for the diagnosis of NEC. Pathognomonic features of NEC seen on x-ray include pneumatosis intestinalis (air within the bowel wall), portal vein air, or pneumoperitoneum from intestinal perforation. NEC should be managed with IV fluids, bowel rest with gastric decompression, IV antibiotics, and surgical consultation.
APA, Harvard, Vancouver, ISO, and other styles
10

Waldmann, Carl, Andrew Rhodes, Neil Soni, and Jonathan Handy. "Gastrointestinal disorders." In Oxford Desk Reference: Critical Care. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198723561.003.0021.

Full text
Abstract:
This chapter discusses gastrointestinal (GI) disorders and includes discussion on vomiting and gastric stasis/gastroparesis, gastric erosions, diarrhoea, upper GI haemorrhage (non-variceal), bleeding varices, intestinal perforation, intestinal obstruction, lower GI bleeding, colitis, pancreatitis, acute acalculous cholecystitis, splanchnic ischaemia, and abdominal hypertension (IAH) and abdominal compartment syndrome. The aim is to provide a summary of the extensive complex abdominal pathologies that can present to an intensive care clinician. Where appropriate, descriptions are provided on clinical presentation, epidemiology, diagnosis (including investigations), and management. Of note, the conditions covered can arise on the ward environment with subsequent requirement for intensive care, but they can also arise de novo on the intensive care unit itself, highlighting the need for intensive care clinicians to maintain a broad knowledge and understanding of their presentation and management.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Intestinal Perforation"

1

Trelles, D., D. S. Bustamante-Soliz, and N. Martinez. "Intestinal Perforation in COVID 19." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5269.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Trevisan, Bruno, Vanda Lais de Oliveira Turkot, Mauro Nicollas Oliveira Silverio, et al. "INTESTINAL PERFORATION FOLLOWING ACCIDENTAL METHOTREXATE INTOXICATION - CASE REPORT." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.2036.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Hamedi, Z., R. A. Jiwani, S. Kumar, N. Mainkar, and N. Sharma. "Nivolumab Induced Intestinal Perforation in a Patient with Lung Cancer." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4867.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Garg, Gunjal, Shabnam Pourbolghasem, Gongfu Zhou, et al. "Abstract 1378: Factors influencing survival in gynecologic oncology patients diagnosed with intestinal perforation and pneumatosis intestinalis." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1378.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Ruth, Nicola, Sebastian Broqn, Charlotte Roberts-Rhodes, SherShah Pervez, and Babu Kumararatne. "177 Intestinal perforation in preterm infants receiving non-invasive ventilation – a case series." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Glasgow, 23–25 May 2023. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2023. http://dx.doi.org/10.1136/archdischild-2023-rcpch.224.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Pervanlar, Ayşe, Ayça Sözen, Tuğba Erener Ercan, and David Terence Thomas. "P470 Spontaneous intestinal perforation in an extremely low birth weight infant: a case report." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.806.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Khatun, Salma, Timothy Bradnock, Judith Simpson, and Claire Granger. "1125 A retrospective comparison of short-term outcomes following spontaneous intestinal perforation and necrotising enterocolitis." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 15 June 2021–17 June 2021. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2021. http://dx.doi.org/10.1136/archdischild-2021-rcpch.415.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Petrone, A., P. Scrivano, A. Corsonello, et al. "Case report: Spontaneous pneumomediastinum (SPM) and intestinal perforation secondary to COVID-19 in the same patient." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2498.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Stewart, EJ, C. Granger, and J. O’Shea. "G457(P) Cases of neonatal spontaneous intestinal perforation in a tertiary care centre over a 5 year period." In Royal College of Paediatrics and Child Health, Abstracts of the Annual Conference, 24–26 May 2017, ICC, Birmingham. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313087.450.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Menardi, G., G. Tarasco, A. Castellino, et al. "5PSQ-065 Intestinal perforation after CRS and ICANS in a Car-T treated patient: a clinical case report." In 28th EAHP Congress, Bordeaux, France, 20-21-22 March 2024. British Medical Journal Publishing Group, 2024. http://dx.doi.org/10.1136/ejhpharm-2024-eahp.399.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Intestinal Perforation"

1

Newman-Toker, David E., Susan M. Peterson, Shervin Badihian, et al. Diagnostic Errors in the Emergency Department: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), 2022. http://dx.doi.org/10.23970/ahrqepccer258.

Full text
Abstract:
Objectives. Diagnostic errors are a known patient safety concern across all clinical settings, including the emergency department (ED). We conducted a systematic review to determine the most frequent diseases and clinical presentations associated with diagnostic errors (and resulting harms) in the ED, measure error and harm frequency, as well as assess causal factors. Methods. We searched PubMed®, Cumulative Index to Nursing and Allied Health Literature (CINAHL®), and Embase® from January 2000 through September 2021. We included research studies and targeted grey literature reporting diagnostic errors or misdiagnosis-related harms in EDs in the United States or other developed countries with ED care deemed comparable by a technical expert panel. We applied standard definitions for diagnostic errors, misdiagnosis-related harms (adverse events), and serious harms (permanent disability or death). Preventability was determined by original study authors or differences in harms across groups. Two reviewers independently screened search results for eligibility; serially extracted data regarding common diseases, error/harm rates, and causes/risk factors; and independently assessed risk of bias of included studies. We synthesized results for each question and extrapolated U.S. estimates. We present 95 percent confidence intervals (CIs) or plausible range (PR) bounds, as appropriate. Results. We identified 19,127 citations and included 279 studies. The top 15 clinical conditions associated with serious misdiagnosis-related harms (accounting for 68% [95% CI 66 to 71] of serious harms) were (1) stroke, (2) myocardial infarction, (3) aortic aneurysm and dissection, (4) spinal cord compression and injury, (5) venous thromboembolism, (6/7 – tie) meningitis and encephalitis, (6/7 – tie) sepsis, (8) lung cancer, (9) traumatic brain injury and traumatic intracranial hemorrhage, (10) arterial thromboembolism, (11) spinal and intracranial abscess, (12) cardiac arrhythmia, (13) pneumonia, (14) gastrointestinal perforation and rupture, and (15) intestinal obstruction. Average disease-specific error rates ranged from 1.5 percent (myocardial infarction) to 56 percent (spinal abscess), with additional variation by clinical presentation (e.g., missed stroke average 17%, but 4% for weakness and 40% for dizziness/vertigo). There was also wide, superimposed variation by hospital (e.g., missed myocardial infarction 0% to 29% across hospitals within a single study). An estimated 5.7 percent (95% CI 4.4 to 7.1) of all ED visits had at least one diagnostic error. Estimated preventable adverse event rates were as follows: any harm severity (2.0%, 95% CI 1.0 to 3.6), any serious harms (0.3%, PR 0.1 to 0.7), and deaths (0.2%, PR 0.1 to 0.4). While most disease-specific error rates derived from mainly U.S.-based studies, overall error and harm rates were derived from three prospective studies conducted outside the United States (in Canada, Spain, and Switzerland, with combined n=1,758). If overall rates are generalizable to all U.S. ED visits (130 million, 95% CI 116 to 144), this would translate to 7.4 million (PR 5.1 to 10.2) ED diagnostic errors annually; 2.6 million (PR 1.1 to 5.2) diagnostic adverse events with preventable harms; and 371,000 (PR 142,000 to 909,000) serious misdiagnosis-related harms, including more than 100,000 permanent, high-severity disabilities and 250,000 deaths. Although errors were often multifactorial, 89 percent (95% CI 88 to 90) of diagnostic error malpractice claims involved failures of clinical decision-making or judgment, regardless of the underlying disease present. Key process failures were errors in diagnostic assessment, test ordering, and test interpretation. Most often these were attributed to inadequate knowledge, skills, or reasoning, particularly in “atypical” or otherwise subtle case presentations. Limitations included use of malpractice claims and incident reports for distribution of diseases leading to serious harms, reliance on a small number of non-U.S. studies for overall (disease-agnostic) diagnostic error and harm rates, and methodologic variability across studies in measuring disease-specific rates, determining preventability, and assessing causal factors. Conclusions. Although estimated ED error rates are low (and comparable to those found in other clinical settings), the number of patients potentially impacted is large. Not all diagnostic errors or harms are preventable, but wide variability in diagnostic error rates across diseases, symptoms, and hospitals suggests improvement is possible. With 130 million U.S. ED visits, estimated rates for diagnostic error (5.7%), misdiagnosis-related harms (2.0%), and serious misdiagnosis-related harms (0.3%) could translate to more than 7 million errors, 2.5 million harms, and 350,000 patients suffering potentially preventable permanent disability or death. Over two-thirds of serious harms are attributable to just 15 diseases and linked to cognitive errors, particularly in cases with “atypical” manifestations. Scalable solutions to enhance bedside diagnostic processes are needed, and these should target the most commonly misdiagnosed clinical presentations of key diseases causing serious harms. New studies should confirm overall rates are representative of current U.S.-based ED practice and focus on identified evidence gaps (errors among common diseases with lower-severity harms, pediatric ED errors and harms, dynamic systems factors such as overcrowding, and false positives). Policy changes to consider based on this review include: (1) standardizing measurement and research results reporting to maximize comparability of measures of diagnostic error and misdiagnosis-related harms; (2) creating a National Diagnostic Performance Dashboard to track performance; and (3) using multiple policy levers (e.g., research funding, public accountability, payment reforms) to facilitate the rapid development and deployment of solutions to address this critically important patient safety concern.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Intestinal Perforation' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography