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Journal articles on the topic 'Intestine microbiota'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Ma, Wenyao, Zhe Han, Xinlei Liu, et al. "Distinct Effects of Lactiplantibacillus plantarum HNU082 on Microbial Single-Nucleotide Variants in Large Intestine and Small Intestine." Microorganisms 13, no. 4 (2025): 731. https://doi.org/10.3390/microorganisms13040731.

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The intestinal tract extends several times the length of bodies, with varying environmental conditions across different segments (small intestinal and large intestinal), thereby harboring distinct gut microbiota. Most studies focused on the quantitative responses of gut microbiota upon probiotics entering the gut, without an in-depth analysis of how the genetic change in local gut microbiota. Therefore, in this experiment, C57BL/6J male mice were once administered Lactiplantibacillus plantarum HNU082 (Lp082). Then, the mice were euthanized on the 1st, 3rd, and 7th days after gavage, and the co

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Shang, Yongquan, Huaming Zhong, Gang Liu, et al. "Characteristics of Microbiota in Different Segments of the Digestive Tract of Lycodon rufozonatus." Animals 13, no. 4 (2023): 731. http://dx.doi.org/10.3390/ani13040731.

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The gastrointestinal tract of animals contains microbiota, forming a complex microecosystem. Gut microbes and their metabolites can regulate the development of host innate and adaptive immune systems. Animal immune systems maintain intestinal symbiotic microbiota homeostasis. However, relatively few studies have been published on reptiles, particularly snakes, and even fewer studies on different parts of the digestive tracts of these animals. Herein, we used 16S rRNA gene sequencing to investigate the microbial community composition and adaptability in the stomach and small and large intestine

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Wang, Shumeng, Junyi Luo, Hailong Wang, et al. "Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond." International Journal of Molecular Sciences 25, no. 6 (2024): 3478. http://dx.doi.org/10.3390/ijms25063478.

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The intestinal ecological environment plays a crucial role in nutrient absorption and overall well-being. In recent years, research has focused on the effects of extracellular vesicles (EVs) in both physiological and pathological conditions of the intestine. The intestine does not only consume EVs from exogenous foods, but also those from other endogenous tissues and cells, and even from the gut microbiota. The alteration of conditions in the intestine and the intestinal microbiota subsequently gives rise to changes in other organs and systems, including the central nervous system (CNS), namel

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Wang, Xinzhou, Peng Zhang, and Xin Zhang. "Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity." Molecules 26, no. 19 (2021): 6076. http://dx.doi.org/10.3390/molecules26196076.

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Probiotics are beneficial active microorganisms that colonize the human intestines and change the composition of the flora in particular parts of the host. Recently, the use of probiotics to regulate intestinal flora to improve host immunity has received widespread attention. Recent evidence has shown that probiotics play significant roles in gut microbiota composition, which can inhibit the colonization of pathogenic bacteria in the intestine, help the host build a healthy intestinal mucosa protective layer, and enhance the host immune system. Based on the close relationship between the gut m

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Ruigrok, Renate A. A. A., Valerie Collij, Paula Sureda, et al. "The Composition and Metabolic Potential of the Human Small Intestinal Microbiota Within the Context of Inflammatory Bowel Disease." Journal of Crohn's and Colitis 15, no. 8 (2021): 1326–38. http://dx.doi.org/10.1093/ecco-jcc/jjab020.

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Abstract Background and Aims The human gastrointestinal tract harbours distinct microbial communities essential for health. Little is known about small intestinal communities, despite the small intestine playing a fundamental role in nutrient absorption and host-microbe immune homeostasis. We aimed to explore the small intestine microbial composition and metabolic potential, in the context of inflammatory bowel disease [IBD]. Methods Metagenomes derived from faecal samples and extensive phenotypes were collected from 57 individuals with an ileostomy or ileoanal pouch, and compared with 1178 ge

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Kaibysheva, V. O., M. E. Zharova, K. Yu Filimendikova, and E. L. Nikonov. "Diseases Associated with Disturbed Intestinal Microbiota." Doctor.Ru 20, no. 4 (2021): 40–45. http://dx.doi.org/10.31550/1727-2378-2021-20-4-40-45.

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Objective of the Review: To discuss changes in intestinal microbiota in various diseases. Key Points. Microbial intestinal imbalance plays an important role in pathogenesis and/or progression of a number of diseases, namely of Clostridium difficile-associated disorders, intestinal inflammations, obesity, colorectal cancer, autistic disorders and other. Moreover, therapies involving faecal microbiota transplantation, use of pro- and prebiotics, metabiotics proved efficient in management of some of the above disorders. Conclusion. So far, some mechanisms have been explored which explain possible

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GIURGIU, Gheorghe, and Manole COJOCARU. "Natural Neuroimunomodulation in Coronavirus Infection." Annals of the Academy of Romanian Scientists Series on Biological Sciences 9, no. 2 (2020): 80–87. http://dx.doi.org/10.56082/annalsarscibio.2020.2.80.

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Dysbiosis of the nasopharyngeal microbiome attracts dysbiosis of the intestinal microbiome and activation of the intestinal microbiome-brain axis. If the first sign of the disease is quickly intervened with the modulation of the activity of the microbiome, implicitly of the immune system (neuroimmunomodulation), the appearance of the disease is eliminated. There is the microbiome: buccal, nasal, intestinal, cardiac, cutaneous and even the microbiome in the brain with which Covid-19 interacts. When the evolution is complicated, it is necessary to intervene with drug treatment to support the aff

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Li, Lin-Yi, Jie Zhou, Cun-Hao Mao, et al. "Exploration of the Effects of Agarwood Extract on the Inflammtory Microbiota in the Oral-Gut Axis." Science Journal of Public Health 12, no. 3 (2024): 79–82. http://dx.doi.org/10.11648/j.sjph.20241203.13.

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Agarwood, as a precious medicinal material with distinctive characteristics from Hainan, has been shown in recent studies to possess significant anti-inflammatory and antibacterial properties. With the rapid growth in public recognition of health concepts, oral health has garnered increased attention. The main focus of this study is the impact of agarwood extracts on the oral-gut axis microbiota. The relationship between the oral and gut microbiota is closely intertwined, where oral microbiota can directly colonize the intestine via saliva and other means, altering the original microbial compo

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Kwon, Jungnam, Dong Han Yeom, Moon Yong Lee, and Yong Sung Kim. "Role of the Small Intestinal Microbiota in Gastrointestinal Disorders." Korean Journal of Helicobacter and Upper Gastrointestinal Research 24, no. 4 (2024): 339–45. https://doi.org/10.7704/kjhugr.2024.0059.

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The small intestinal microbiota plays a crucial role in maintaining the health and pathogenesis of various gastrointestinal disorders. Despite extensive research on gut microbiota, studies focusing on the small intestine are limited owing to methodological challenges. This review discusses the taxonomic composition, microbial load, and diversity of normal small intestinal microbiota. Additionally, it highlights the role of small intestinal microbiota in gastrointestinal disorders, such as functional dyspepsia, small intestinal bacterial overgrowth, and nonsteroidal anti-inflammatory drug-induc

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Dedikova, Olga V., Irina N. Zakharova, Anastasiya E. Kuchina, Irina V. Berezhnaya, and Narine G. Sugian. "Formation of the infant's intestinal microbiota depending on the delivery method: long-term consequences and correction options: A review." Pediatrics. Consilium Medicum, no. 1 (June 6, 2023): 25–29. http://dx.doi.org/10.26442/26586630.2023.1.202092.

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Many studies have been devoted to human microbiome. It has been shown that the microbiome has a significant effect on almost all the vital functions of the host organism. The article addresses the role of various factors in newborns' intestinal microbiota formation. The main emphasis was on the delivery method since the intestinal microbiota of children born via vaginal delivery differs from those born by cesarean section. The microbiota of the mother's intestine and vagina greatly influences the formation of the intestinal microbiome. The delivery method affects not only the formation of the

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Bi, Kefan, Xujun Zhang, Wenbiao Chen, and Hongyan Diao. "MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review." Genes 11, no. 9 (2020): 1075. http://dx.doi.org/10.3390/genes11091075.

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MicroRNAs are small non-coding RNAs regulating gene expression at the post-transcriptional level. The regulation of microRNA expression in the gut intestine is gradually recognized as one of the crucial contributors of intestinal homeostasis and overall health. Recent studies indicated that both the microRNAs endogenous in the gut intestine and exogenous from diets could play influential roles in modulating microbial colonization and intestinal immunity. In this review, we discuss the biological functions of microRNAs in regulating intestinal homeostasis by modulating intestinal immune respons

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Singhal, Rashi, and Yatrik M. Shah. "Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine." Journal of Biological Chemistry 295, no. 30 (2020): 10493–505. http://dx.doi.org/10.1074/jbc.rev120.011188.

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The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also harbors a large and diverse microbial population collectively called the gut microbiome (microbiota). The microbiome–intestine cross-talk includes a dynamic exchange of gaseous signaling mediators generated by bacterial and intestinal metabolisms. Moreover, the microbiome initiates and maintains the hypoxic environment of the intestine that is critical for nutrient absorption, intestinal barrier function, and innate and adaptive immune responses in the mucosal cells of the intestine. The response t

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Kuznetsov, А. V., О. V. Sorokin, L. Yu Kostina, et al. "Morphological features and microbiota of the small intestine." Journal of Siberian Medical Sciences 7, no. 4 (2023): 7–22. http://dx.doi.org/10.31549/2542-1174-2023-7-4-7-22.

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a single organ, without a clear division into segments. The problem of intestinal anastomotic leakage has not yet been resolved, and its proportion is from 3.4 to 15.3%, with a mortality rate of up to 18.6%. Identification of the anatomical features of different segments of the small intestine and their contents is of practical importance in surgery in terms of prevention of complications. Aim. Identification of morphological features of different segments of the small intestine and their microbiota. Materials and methods. An examination of 26 samples of the small intestine during autopsy was

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Neophytou, Constantina, and Chrysoula Pitsouli. "How Gut Microbes Nurture Intestinal Stem Cells: A Drosophila Perspective." Metabolites 12, no. 2 (2022): 169. http://dx.doi.org/10.3390/metabo12020169.

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Host-microbiota interactions are key modulators of host physiology and behavior. Accumulating evidence suggests that the complex interplay between microbiota, diet and the intestine controls host health. Great emphasis has been given on how gut microbes have evolved to harvest energy from the diet to control energy balance, host metabolism and fitness. In addition, many metabolites essential for intestinal homeostasis are mainly derived from gut microbiota and can alleviate nutritional imbalances. However, due to the high complexity of the system, the molecular mechanisms that control host-mic

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Kanezawa, Shini, Mitsuhiko Moriyama, Tatsuo Kanda, et al. "Gut-Microbiota Dysbiosis in Stroke-Prone Spontaneously Hypertensive Rats with Diet-Induced Steatohepatitis." International Journal of Molecular Sciences 24, no. 5 (2023): 4603. http://dx.doi.org/10.3390/ijms24054603.

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Metabolic-dysfunction-associated fatty-liver disease (MAFLD) is the principal worldwide cause of liver disease. Individuals with nonalcoholic steatohepatitis (NASH) have a higher prevalence of small-intestinal bacterial overgrowth (SIBO). We examined gut-microbiota isolated from 12-week-old stroke-prone spontaneously hypertensive-5 rats (SHRSP5) fed on a normal diet (ND) or a high-fat- and high-cholesterol-containing diet (HFCD) and clarified the differences between their gut-microbiota. We observed that the Firmicute/Bacteroidetes (F/B) ratio in both the small intestines and the feces of the

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Song, Xiaojun, Ying Lin, Yinfeng Zhang, et al. "Long-Term Tetrabromobisphenol A Exposure Induces Gut Microbiota Imbalance and Metabolic Disorders via the Peroxisome Proliferator-Activated Receptor Signaling Pathway in the Regenerated Gut of Apostichopus japonicus." Biology 12, no. 11 (2023): 1365. http://dx.doi.org/10.3390/biology12111365.

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Tetrabromobisphenol A (TBBPA), a commonly utilized brominated flame retardant, is found in many types of abiotic and biotic matrices. TBBPA can increase oxidative stress, disrupt the endocrine system, cause neurodevelopmental disorders and activate peroxisome proliferator-activated receptors to modulate lipid deposits in aquatic animals. However, the toxic mechanism of TBBPA on the gut microbiota and intestinal health remains unclear. Apostichopus japonicus is an ideal model for studying the relationship between environmental contaminants and intestinal health due to its unique capacity for ev

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Pohl, Judith-Mira, Sebastian Gutweiler, Stephanie Thiebes, et al. "Irf4-dependent CD103+CD11b+dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus." Gut 66, no. 12 (2017): 2110–20. http://dx.doi.org/10.1136/gutjnl-2017-313856.

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ObjectivePostoperative ileus (POI), the most frequent complication after intestinal surgery, depends on dendritic cells (DCs) and macrophages. Here, we have investigated the mechanism that activates these cells and the contribution of the intestinal microbiota for POI induction.DesignPOI was induced by manipulating the intestine of mice, which selectively lack DCs, monocytes or macrophages. The disease severity in the small and large intestine was analysed by determining the distribution of orally applied fluorescein isothiocyanate-dextran and by measuring the excretion time of a retrogradely

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Wang, Jian, Fengqi Li, Haiming Wei, Zhe-Xiong Lian, Rui Sun, and Zhigang Tian. "Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation." Journal of Experimental Medicine 211, no. 12 (2014): 2397–410. http://dx.doi.org/10.1084/jem.20140625.

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Influenza in humans is often accompanied by gastroenteritis-like symptoms such as diarrhea, but the underlying mechanism is not yet understood. We explored the occurrence of gastroenteritis-like symptoms using a mouse model of respiratory influenza infection. We found that respiratory influenza infection caused intestinal injury when lung injury occurred, which was not due to direct intestinal viral infection. Influenza infection altered the intestinal microbiota composition, which was mediated by IFN-γ produced by lung-derived CCR9+CD4+ T cells recruited into the small intestine. Th17 cells m

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Yamamoto, Yuri, Yumiko Nakanishi, Shinnosuke Murakami, et al. "A Metabolomic-Based Evaluation of the Role of Commensal Microbiota throughout the Gastrointestinal Tract in Mice." Microorganisms 6, no. 4 (2018): 101. http://dx.doi.org/10.3390/microorganisms6040101.

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Commensal microbiota colonize the surface of our bodies. The inside of the gastrointestinal tract is one such surface that provides a habitat for them. The gastrointestinal tract is a long organ system comprising of various parts, and each part possesses various functions. It has been reported that the composition of intestinal luminal metabolites between the small and large intestine are different; however, comprehensive metabolomic and commensal microbiota profiles specific to each part of the gastrointestinal lumen remain obscure. In this study, by using capillary electrophoresis time-of-fl

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Smirnova, Galina I., Vladimir S. Labinov, and Anatoliy A. Korsunskiy. "Irritable bowel syndrome in children: pathogenetic significance of disorders of intestinal microbiota." Russian Pediatric Journal 27, no. 1 (2024): 49–54. http://dx.doi.org/10.46563/1560-9561-2024-27-1-49-54.

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Irritable bowel syndrome (IBS) is the most common functional disorder of the intestine in children. In recent years, IBS has been defined as functional pathology of the intestine, manifested by visceral recurrent pain that occurs at least once per week, characterized by the following two or more signs: associated with defecation; with changes in the frequency and shape of stools. These symptoms had to be noted in the patient for the last 3 months, with a total duration of at least 6 months, without signs of organic damage to the gastrointestinal tract (GIT). The gut microbiota is of particular

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Ren, Wenkai, Shuai Chen, Liwen Zhang, et al. "Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17." Mediators of Inflammation 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2839232.

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This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage ofFirmicutesand increasingBacteroidetesin the jejunum and ileum; (2) enhancing the percentage ofFirmicutesbut decreasingBacteroidetesin the colon and feces; (3) decreasingLactobacillusin t

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Li, Xiaoyu, Zhibang Yang, Jia Liu, and Ying Jiang. "High-throughput Sequencing Analysis and Function Prediction of Lung Microbiota in Healthy Rats." International Journal of Healthcare and Medical Sciences, no. 53 (March 15, 2019): 12–17. http://dx.doi.org/10.32861/ijhms.53.12.17.

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To form the basis of a respiratory disease model in rats by investigating the microbial distribution and composition in the lower respiratory tracts of normal rats. Methods: DNA was extracted from the intestine, trachea, bronchus and lung samples collected from healthy rats under sterile conditions. The 16S rDNA V4-V5 region was sequenced using Illumina high-throughput technology. Results: The sequencing results showed that there was no significant difference in abundance and species diversity of microbiota between the lower respiratory and the intestine. The microbiota structure analysis show

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Lee, Gilbert Aaron, Yu-Wei Chang, Wan-Li Lin, et al. "Modulatory Effects of Heat-Inactivated Streptococcus Thermophilus Strain 7 on the Inflammatory Response: A Study on an Animal Model with TLR3-Induced Intestinal Injury." Microorganisms 11, no. 2 (2023): 278. http://dx.doi.org/10.3390/microorganisms11020278.

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Rotavirus infections result in severe gastroenteritis with a detrimental inflammatory response in the intestine. Because probiotics have an anti-inflammatory effect and can modulate the gut microbiota profile, they can be used as a biotherapy for inflammatory intestinal diseases. In this study, we isolated Streptococcus thermophilus strain 7 (ST7) from cow milk and examined the effect of heat-inactivated ST7 on the intestinal histopathological score, inflammatory cytokine levels, T-cell activation and effector function, and microbiome profile in a mouse model with intestinal injury induced by

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Lietzén, Martin S., Maria Angela Guzzardi, Ronja Ojala, et al. "Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI." Nutrients 16, no. 20 (2024): 3554. http://dx.doi.org/10.3390/nu16203554.

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Background/Objectives: Obesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influence the risk of obesity and gut microbiome. However, the role of genetics on the effects of exercise on intestinal GU and microbiome is unclear. Methods: Twelve monozygotic twin pairs discordant for BMI (age 40.4 ± 4.5 years, BMI heavier 36.7 ± 6.0, leaner 29.1 ± 5.7, 8 female pairs) performed a six-month-long training intervention. Small intestine and colon

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Wronka, Dorota, Anna Karlik, Julia O. Misiorek, and Lukasz Przybyl. "What the Gut Tells the Brain—Is There a Link between Microbiota and Huntington’s Disease?" International Journal of Molecular Sciences 24, no. 5 (2023): 4477. http://dx.doi.org/10.3390/ijms24054477.

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The human intestinal microbiota is a diverse and dynamic microenvironment that forms a complex, bi-directional relationship with the host. The microbiome takes part in the digestion of food and the generation of crucial nutrients such as short chain fatty acids (SCFA), but is also impacts the host’s metabolism, immune system, and even brain functions. Due to its indispensable role, microbiota has been implicated in both the maintenance of health and the pathogenesis of many diseases. Dysbiosis in the gut microbiota has already been implicated in many neurodegenerative diseases such as Parkinso

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Amillano-Cisneros, Jesús Mateo, Perla T. Hernández-Rosas, Bruno Gomez-Gil, et al. "Loss of gut microbial diversity in the cultured, agastric fish, Mexican pike silverside (Chirostoma estor: Atherinopsidae)." PeerJ 10 (March 7, 2022): e13052. http://dx.doi.org/10.7717/peerj.13052.

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Teleost fish are the most diverse group of extant vertebrates and have varied digestive anatomical structures and strategies, suggesting they also possess an array of different host-microbiota interactions. Differences in fish gut microbiota have been shown to affect host development, the process of gut colonization, and the outcomes of gene-environment or immune system-microbiota interactions. There is generally a lack of studies on the digestive mechanisms and microbiota of agastric short-intestine fish however, meaning that we do not understand how changes in gut microbial diversity might i

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Diehl, Gretchen, Carolina Galan, Randy Longman, Takeshi Egawa, Yi Yang, and Dan Littman. "The microbiota conditions CX3CR1+ intestinal mononuclear phagocytes to limit intestinal inflammation. (MUC2P.822)." Journal of Immunology 192, no. 1_Supplement (2014): 68.6. http://dx.doi.org/10.4049/jimmunol.192.supp.68.6.

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Abstract Regulation of intestinal immune responses requires distinguishing normal beneficial bacteria (the microbiota) from pathogens capable of inducing disease. While it is clear that the intestine and intestinal immune system recognize and respond to the microbiota, it is unclear how this recognition influences subsequent immune responses. One intestinal antigen presenting cell population, characterized by expression of the chemokine receptor CX3CR1, has been described as tissue resident macrophages. In contrast to previous reports, we recently demonstrated that CX3CR1+ cells migrate from t

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Malygina, Olga G., Anna A. Usynina, and Anna A. Makarova. "Association between Intestinal Microbiota in Infants and their Neurodevelopment: Systematic Literature Review on Scoping Review Methodology." Current Pediatrics 23, no. 1 (2024): 13–20. http://dx.doi.org/10.15690/vsp.v23i1.2706.

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Background. The long-term effects of large intestine microbiota or its disorders on human health remain largely unexplored. Particularly the issue of an association between the intestinal microbiota in newborns and infants with their further neurodevelopment remains unclear. Objective. The aim of the study is to systematically summarize studies' results on the association of large intestine microbiota (its normal composition and in case of any disorders) in newborns and infants and their neurodevelopment until the age of 1 year. Methods. The search of publications was performed in the followin

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Lv, Xinjia, Shihao Li, Yang Yu, Xiaojun Zhang, and Fuhua Li. "Crustin Defense against Vibrio parahaemolyticus Infection by Regulating Intestinal Microbial Balance in Litopenaeus vannamei." Marine Drugs 21, no. 2 (2023): 130. http://dx.doi.org/10.3390/md21020130.

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Crustins are a kind of antimicrobial peptide (AMP) that exist in crustaceans. Some crustins do not have direct antimicrobial activity but exhibit in vivo defense functions against Vibrio. However, the underlying molecular mechanism is not clear. Here, the regulatory mechanism was partially revealed along with the characterization of the immune function of a type I crustin, LvCrustin I-2, from Litopenaeus vannamei. LvCrustin I-2 was mainly detected in hemocytes, intestines and gills and was apparently up-regulated after Vibrio parahaemolyticus infection. Although the recombinant LvCrustin I-2 p

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Zhou, Lei, Ke-tao Lin, Lian Gan, et al. "Intestinal Microbiota of Grass Carp Fed Faba Beans: A Comparative Study." Microorganisms 7, no. 10 (2019): 465. http://dx.doi.org/10.3390/microorganisms7100465.

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Many reports of the intestinal microbiota of grass carp have addressed the microbial response to diet or starvation or the effect of microbes on metabolism; however, the intestinal microbiota of crisp grass carp has yet to be elucidated. Moreover, the specific bacteria that play a role in the crispiness of grass carp fed faba beans have not been elucidated. In the present study, 16S sequencing was carried out to compare the intestinal microbiota in the fore-, mid- and hind-intestine segments of grass carp following feeding with either faba beans or formula feed. Our results showed that (1) the

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Zamudio Tiburcio, Alvaro, Héctor Bermudez Ruiz, Silverio Alonso Lopez, and Pedro Antonio Reyes Lopez. "Breast Cancer and Intestinal Microbiota Transplantation." Journal of Clinical Research and Clinical Trials 2, no. 3 (2023): 1–8. http://dx.doi.org/10.59657/2837-7184.brs.23.018.

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Breast cancer has been studied relating it to the intestinal microbiota and its own microbiota. Giving a primary role to the dysbiosis that occurs in both the mammary gland and the intestine. Likewise, metabolic processes and immunological eventualities have been considered as determining factors; By the way, many of them are determined by the intestinal microbiota itself, which is given the deserved name of endocrine gland, because it acts at a distance, and it is not only the super-organ or the new organ, but the multiple studies have generated this honorable new consideration. We break down

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Fadieienko, G. D., O. Y. Gridnyev, and N. I. Chereliuk. "Intestinal microbiota and metabolically associated steatotic liver disease: current understanding of the problem. Review." Modern Gastroenterology, no. 3 (September 19, 2024): 39–52. http://dx.doi.org/10.30978/mg-2024-3-39.

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Cross‑interaction of microbes, microbial products, and the intestinal barrier are components of the so‑called «intestine‑liver axis», as the liver and intestines have a close two‑way relationship. In patients with metabolically associated steatotic liver disease (MASLD), significant characteristic changes in the intestinal microbiome are observed, in particular, the growth of gram‑negative bacteria, which contributes to the formation of a pro‑inflammatory status (primarily due to endotocins) and disruption of metabolic processes, while an increase in Bacteroides and Ruminococcus and a decrease

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Acquarone, Mario, Alejandro Salgado-Flores, and Monica Alterskjær Sundset. "The Bacterial Microbiome in the Small Intestine of Hooded Seals (Cystophora cristata)." Microorganisms 8, no. 11 (2020): 1664. http://dx.doi.org/10.3390/microorganisms8111664.

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Arctic hooded seals (Cystophora cristata) are monogastric carnivores that go through extreme fasting and re-feeding in early life. They are born isolated on sea ice; suckle high-fat milk for four days and may then fast for up to one month before they start hunting and feeding on small prey (fish and crustaceans). Previous studies of the gut microbiota in pinnipeds have focused on the large intestine, while little data exist on the small intestinal microbiota. In this study, the bacterial microbiome in the proximal and distal small intestine of four captive two-year old seals (two males and two

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Zhi, Wenbo, Kai Tang, Jinsong Yang, et al. "Research on the Gut Microbiota of Hainan Black Goat." Animals 12, no. 22 (2022): 3129. http://dx.doi.org/10.3390/ani12223129.

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The intestine of animals is a complex micro-ecosystem containing a large number of microbiomes, which is essential for the host’s health development. The Hainan black goat with good resistance and adaptability is a unique species in Hainan, China. These unique physiological characteristics are inseparable from their intestinal microbiota. In this study, high-throughput sequencing was used to investigate bacterial communities in different segments of the intestinal tract of Hainan black goat. The results showed that the indices of Chao1 and ACE in the cecum and colon were significantly greater

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Belova, G. V., and A. A. Tashmatova. "Brain and microbiota: a new regulator of critical illnesses." Filin’s Clinical endoscopy 66, no. 1 (2024): 41–48. http://dx.doi.org/10.31146/2415-7813-endo-66-1-41-48.

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One of the current interdisciplinary problems of medicine, including in patients with critical conditions, in particular with brain damage, is the correction of microecological disorders of the intestine. Based on the analysis of the composition, assessment of the functions of the intestinal microflora and the mechanisms for implementing the relationships "microflora - macroorganism", "intestine-brain", "intestine-liver", as well as the causes leading to their microecological disorders, the need and possibility of timely correction are shown.

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Zabolotneva, A. A., M. D. Makeev, A. V. Fesenko, S. A. Roumiantsev, and A. V. Shestopalov. "Supplementation with Pentadecylresorcinol to a High-Fat Diet Increases the Predicted Representation of Enzymes and Metabolic Pathways for Vitamin B12 Synthesis by the Gut Microbiota Of C57bl6 Mice." Obesity and metabolism 22, no. 1 (2025): 4–11. https://doi.org/10.14341/omet13198.

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5-Pentadecylresorcinol (C15) is a natural alkylresorcinol that has been shown to protect against complications caused by imbalanced nutrition. Although the exact mechanisms of beneficial activity of C15 are not known, we assume that the protective effects of C15 on metabolic health are mediated by their modulatory influence on the composition of the intestinal microbiota and functional activity. Cobamides and vitamin B12 are believed to be crucial modulators of mammalian gut ecosystems. We proposed that C15 may influence the representation of enzymes and pathways for vitamin B12 synthesis in t

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Wang, Kai, Hailiang Zhang, Lirong Hu, et al. "Characterization of the Microbial Communities along the Gastrointestinal Tract in Crossbred Cattle." Animals 12, no. 7 (2022): 825. http://dx.doi.org/10.3390/ani12070825.

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The gastrointestinal microbiota greatly affects the health status and production performance of bovines. Presently, many studies have used high-throughput sequencing methods to investigate the gastrointestinal microbiome in bovines. However, the microbiome profile of crossbred cattle across the whole gastrointestinal tract (GIT) has not been thoroughly reported. In this study, the digesta at ten regions (including the rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, cecum, colon, and rectum) of the GIT were collected in three Simmental × Holstein crossbred heifers aged 17 months,

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Elson, Charles O., and Katie L. Alexander. "Host-Microbiota Interactions in the Intestine." Digestive Diseases 33, no. 2 (2015): 131–36. http://dx.doi.org/10.1159/000369534.

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The comprehensive collection of bacterial species, termed microbiota, within human and other mammalian hosts has profound effects on both innate and adaptive immunity. Multiple host innate mechanisms contribute to intestinal homeostasis, including epithelial production of protective mucin layers maintaining spatial segregation in the intestine as well as epithelial cell secretion of a broad range of antimicrobial peptides. Additionally, epithelial cells employ autophagy to contain and eliminate invading bacteria; interestingly, genetic variants in specific autophagy genes are linked to suscept

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Graziela, Rodrigues da Costa, Rodrigues Pinheiro Luann, Marta Nascimento de Oliveira Freitas Francisca, and Sakamoto Figueiredo Rebeca. "A ALTERAÇÃO FUNCIONAL DA MICROBIOTA INTESTINAL E SUA RELAÇÃO COM A OBESIDADE." RevistaFT 27, no. 127 (2023): 65. https://doi.org/10.5281/zenodo.10071865.

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A obesidade é uma causa presente há muitos anos, porém devido ao conhecimento de suas causas e consequências passou a ser considerada uma doença crônica não transmissível. A microbiota intestinal vem sendo estudada em relação a sua atuação em diversas doenças metabólicas. Diante disso, o objetivo deste trabalho foi identificar a relação da obesidade com a microbiota intestinal, observa-se que essa relação de microbiota e obesidade, exerce um grande papel para o desenvolvimento nas desordens metabólicas associadas. Foi desenvolvida uma revisão integrativa de estudo sobre a relação da alteração

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Maier, Irene. "Radiation Impacts Microbiota Compositions That Activate Transforming Growth Factor-Beta Expression in the Small Intestine." Microbiology Research 14, no. 2 (2023): 673–88. http://dx.doi.org/10.3390/microbiolres14020048.

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The composition of the gut microbiota represents an early indicator of chronic post-radiation outcomes in elderly bone and gastrointestinal homeostasis. Fecal microbiota analyses revealed that the relative abundances of Bacteroides massiliensis, Muribaculum sp., or Prevotella denticola were different between conventional microbiota (CM) and anti-inflammatory restricted microbiota (RM). The murine RM was found conditional on mucosa-associated dysbiosis under both, disturbances of interleukin (IL)-17 signaling and exposure to radiation alone. This review discusses the hypothesis that intestinal

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Shanahan, Erin R., Gerald Holtmann, and Mark Morrison. "Life in the small intestine: the forgotten microbiome?" Microbiology Australia 38, no. 3 (2017): 116. http://dx.doi.org/10.1071/ma17045.

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The gastrointestinal (GI) microbiota is now widely accepted to be an important modulator of our health and well-being. The microbes colonising the GI tract aid in promoting gut and immune homeostasis, while alterations in the composition and/or density of these microbes, often referred to as dysbiosis, have been implicated in many intestinal and extra-intestinal disorders. As a result, the GI microbiota is of increasing interest as a therapeutic target. This is particularly the case in the context of GI disorders linked to chronic inflammation of the mucosa. In this article, we focus on the sm

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Mishra, Silvash Prasad, and Ravi Kant Avvari. "A preliminary study on the effects of human microRNAs on gut microbiota." Journal of Medical pharmaceutical and allied sciences 12, no. 3 (2023): 5868–73. http://dx.doi.org/10.55522/jmpas.v12i3.5021.

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MicroRNAs (miRNAs) play a key role in disease manifestation, metabolic processes and immune regulation and modulation of the host. MiRNAs can be found in abundance in fecal samples of humans and are present in intracellular, extracellular fluid and extracellular vesicles. Abundance of miRNAs is found to be in ileal lumen as compared to the colon, whereas gut microbiota is more in colon, not in ileum. Still the effect of miRNA is found where the gut microbiota is more, which is by co-localizing with the nucleic acid of the bacteria. Some human miRNAs can regulate the non-coding RNAs in bacteria

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Yi, Ruiya, Bo Yang, Hongjie Zhu, et al. "Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish." Nutrients 16, no. 11 (2024): 1562. http://dx.doi.org/10.3390/nu16111562.

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The imbalance of gut microbiota is an important factor leading to inflammatory bowel disease (IBD). Diffusible signal factor (DSF) is a novel quorum-sensing signal that regulates bacterial growth, metabolism, pathogenicity, and host immune response. This study aimed to explore the therapeutic effect and underlying mechanisms of DSF in a zebrafish colitis model induced by sodium dextran sulfate (DSS). The results showed that intake of DSF can significantly improve intestinal symptoms in the zebrafish colitis model, including ameliorating the shortening of the intestine, reducing the increase in

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Cotter, Paul D. "Small intestine and microbiota." Current Opinion in Gastroenterology 27, no. 2 (2011): 99–105. http://dx.doi.org/10.1097/mog.0b013e328341dc67.

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Zheng, Zhe, Yongshan Liao, Jianming Ye, et al. "Microbiota Diversity in Pearl Oyster Pinctada fucata martensii Intestine and Its Aquaculture Environment." Frontiers in Marine Science 8 (March 23, 2021). http://dx.doi.org/10.3389/fmars.2021.655698.

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Environmental microbiota plays a vital role in the intestinal microbiota of aquatic organisms. However, data concerning the association between the intestinal microbiota of pearl oyster Pinctada fucata martensii and the surrounding seawater are limited. The existing bacterial communities in pearl oyster intestine and surrounding water from two sites (D and H, within Liusha Bay in Guangdong, China) were investigated using 16S rRNA-based sequencing to explore the relationship among the two. D located in the inner bay, and H located in the open sea area outside bay. Results revealed the richness

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Yang, Sen, Lina Qiao, Jing Shi, et al. "Clinical Study of Correlation for the Intestinal and Pharyngeal Microbiota in the Premature Neonates." Frontiers in Pediatrics 9 (February 16, 2021). http://dx.doi.org/10.3389/fped.2021.632573.

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Objective: There are mutual influences between intestine and lung, that propose a concept of the gut-lung axis, but the mechanism is still unclear. Microbial colonization in early life plays an important role in regulating intestinal and lung function. In order to explore the characteristics of early microbiota on the gut-lung axis, we studied the correlation between intestinal and pharyngeal microbiota on day 1 and day 28 after birth in premature neonates.Methods: Thirteen neonates born at 26–32 weeks gestational age (GA) hospitalized at the neonatal intensive care unit (NICU) of the West Chi

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Zhang, Ruiyang, Junpeng Zhang, Wanyi Dang, David M. Irwin, Zhe Wang, and Shuyi Zhang. "Unveiling the Biogeography and Potential Functions of the Intestinal Digesta- and Mucosa-Associated Microbiome of Donkeys." Frontiers in Microbiology 11 (December 4, 2020). http://dx.doi.org/10.3389/fmicb.2020.596882.

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The intestinal microbial composition and metabolic functions under normal physiological conditions in the donkey are crucial for health and production performance. However, compared with other animal species, limited information is currently available regarding the intestinal microbiota of donkeys. In the present study, we characterized the biogeography and potential functions of the intestinal digesta- and mucosa-associated microbiota of different segments of the intestine (jejunum, ileum, cecum, and colon) in the donkey, focusing on the differences in the microbial communities between the sm

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Yang, Shiyong, Chaoyang Zhang, Wenqiang Xu, et al. "Heat Stress Decreases Intestinal Physiological Function and Facilitates the Proliferation of Harmful Intestinal Microbiota in Sturgeons." Frontiers in Microbiology 13 (March 7, 2022). http://dx.doi.org/10.3389/fmicb.2022.755369.

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Heat is a common source of stress in aquatic environments and can alter the physiological and metabolic functions of aquatic animals, especially their intestinal function. Here, the effects of heat stress on the structure and function of the intestine and the characteristics of the intestinal microbiota were studied in sturgeon (Acipenser baerii ♀ × Acipenser schrenckii ♂ hybrid F1). Sturgeons were exposed to sub-extreme (24°C) and extreme (28°C) high water temperatures for 12 days. The heat stress caused systemic damage to the intestine of sturgeons, which displayed severe enteritis in the va

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Guo, Xiao-jing, Tao Jiang, Xu-xiang Ma, et al. "Relationships Between Diurnal Changes of Tongue Coating Microbiota and Intestinal Microbiota." Frontiers in Cellular and Infection Microbiology 12 (March 31, 2022). http://dx.doi.org/10.3389/fcimb.2022.813790.

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The oral cavity and the intestine are the main distribution locations of human digestive bacteria. Exploring the relationships between the tongue coating and gut microbiota, the influence of the diurnal variations of the tongue coating microbiota on the intestinal microbiota can provide a reference for the development of the disease diagnosis and monitoring, as well as the medication time. In this work, a total of 39 healthy college students were recruited. We collected their tongue coating microbiota which was collected before and after sleep and fecal microbiota. The diurnal variations of to

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Ignatiou, Anastasia, and Chrysoula Pitsouli. "Host–diet–microbiota interplay in intestinal nutrition and health." FEBS Letters, June 30, 2024. http://dx.doi.org/10.1002/1873-3468.14966.

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The intestine is populated by a complex and dynamic assortment of microbes, collectively called gut microbiota, that interact with the host and contribute to its metabolism and physiology. Diet is considered a key regulator of intestinal microbiota, as ingested nutrients interact with and shape the resident microbiota composition. Furthermore, recent studies underscore the interplay of dietary and microbiota‐derived nutrients, which directly impinge on intestinal stem cells regulating their turnover to ensure a healthy gut barrier. Although advanced sequencing methodologies have allowed the ch

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