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Dissertations / Theses on the topic 'Intima Hyperplasia'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Rösler, Stefan K. "Die Hämodynamik von femoro-cruralen Bypasanastomosen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2007. http://dx.doi.org/10.18452/15739.

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Die moderne Gefäßchirurgie bedient sich bei hohen Stadien der pAVK, spezieller Gefäßrekonstruktionen in Form von distalen End-zu-Seit-Gefäßanastomosen. Das langfristige Versagen der Gefäßanastomose hängt primär von der Entstehung einer subendothelialen Intimahyperplasie (IH) ab. Diese IH-Gebiete befinden sich je nach Anastomosengeometrie im Gebiet der Hauben- und Fersenzone sowie am Boden der Anastomose. // Mit Hilfe der Particle Image Velocimetry-Technik wird eine Taylor-Patch-, eine Miller-Cuff-Anastomose und eine femoro-crurale Patch-Prothese bezüglich ihrer Flussmuster sowie ihrer hämodyna

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2

Lima, Paulo Roberto da Silva. "Estudo comparativo da hiperplasia miointimal pós-angioplastia na artéria ilíaca externa de coelhos, com aterosclerose induzida, tratados com Allium sativum e colostazol." Universidade Federal de Alagoas, 2015. http://www.repositorio.ufal.br/handle/riufal/2098.

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Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Attempts have been made to inhibit intimal hyperplasia of the arteries with cilostazol and other drugs. Therefore, it is important to address the following research question: what is the difference between the mean of post-angioplasty m

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3

PRANDI, FRANCESCA. "Identification of early pathophysiological events underlying venous coronary bypass stenosis by a mechano-biology approach." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50493.

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Saphenous vein graft disease represents an unresolved problem in coronary artery bypass grafting. After surgery, progressive modification in the vein wall occurs, leading to occlusion of the graft lumen. This process, called intima hyperplasia, involves the participation of vein-resident cells as well as the recruitment of vein-extrinsic cells. Arterial wall strain has recently emerged as one of the factor that can contribute to the pathogenesis of the vein graft disease. Therefore, in collaboration with Department of Bioengineering, Politecnico di Milano we developed a culture system for the

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4

Chen, Changyi. "Intimal hyperplasia in endarterectomized arteries." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/25393.

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5

Jackson, Andrew John. "Cellular aspects of intimal hyperplasia formation." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2417/.

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Introduction: 12,000 infrainguinal bypass grafts are performed annually in the UK. Despite improvements in surgical technique, outcomes remain suboptimal: 20% of above knee grafts require intervention to maintain patency by 3 years. Only antiplatelet agents have been demonstrated thus far to improve graft survival. 80% of graft failure is as a result of intimal hyperplasia, an inflammatory process characterised by the proliferation and migration of vascular smooth muscle cells. Toll Like Receptors (TLR), part of the innate immune system, have been implicated in atherosclerosis formation but no

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6

Religa, Piotr. "Development of intimal hyperplasia in transplant arteriosclerosis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-448-8/.

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7

Porter, Karen Elizabeth. "An investigation into human vein graft intimal hyperplasia." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34203.

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The most common cause of vein bypass graft failure in the postoperative period of 1 month to 1 year is stenosis, which occurs in up to 30% of arterial reconstructions. This thesis investigates the intimal hyperplasia underlying such lesions using a laboratory model. The first chapter reviews the current literature regarding vein graft stenoses and is followed in Chapter 2 by a brief introduction to tissue and organ culture and their usefulness as investigative research tools. Before embarking on a study of a pathological condition, Chapter 3 studies the structure of the "normal" long saphenous

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8

Mellander, Stefan. "On cellular sources for intimal hyperplasia after vascular interventions /." Göteborg : Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/4440.

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9

Kanjickal, Deenu George. "Perivascular Drug Delivery Systems for the Inhibition of Intimal Hyperplasia." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1133715441.

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10

Sivanesan, Sharmila. "Correlating geometry, haemodynamics and intimal hyperplasia in radiocephalic arteriovenous fistulae." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337127.

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11

Favreau, John T. "Oscillatory wall strain reduction precedes arterial intimal hyperplasia in a murine model." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/172.

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Cardiovascular diseases (CVD) remain the most common cause of death in the United States. Additionally, peripheral artery disease affects thousands of people each year. A major underlying cause of these diseases is the occlusion of the coronary or peripheral arteries due to arteriosclerosis. To overcome this, a number of vascular interventions have been developed including angioplasty, stenting, endarterectomies and bypass grafts. Although all of these methods are capable of restoring blood flow to the distal organ after occlusion, they are all plagued by unacceptably high restenosis rates. Wh

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12

Bastijanic, Jennifer M. "Multifunctional Biomimetic Modifications to Address Endothelialization and Intimal Hyperplasia in Vascular Grafts." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1428065969.

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13

Dunlop, Paul. "Clincial and laboratory aspects of intimal hyperplasia in lower limb bypass grafts." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34332.

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This thesis examines aspects of intimal hyperplasia in infrainguinal bypass grafts. There are 3 introductory chapters. Chapter 1 describes the aetiology and treatment of lower limb vascular disease, with particular reference to atherosclerosis. Chapter 2 is a review of the literature regarding the vascular biology of intimal hyperplasia. Chapter 3 is a review of the techniques of cell and organ culture used in the study of vascular disorders. Chapter 4 is composed of four clinical studies of infrainguinal grafts performed at the Leicester Royal Infirmary. There is a prospective study of the lo

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14

Soleimani, Behzad. "Mechanisms of Cardiac Allograft Vasculopathy : Insights from experimental models of transplant intimal hyperplasia." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498247.

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15

TOLVA, VALERIO STEFANO. "A successful experimental model for intimal hyperplasia prevention using a resveratrol delivering balloon." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/76760.

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Restenosis due to intimal hyperplasia is a major clinical problem that compromises the success of angioplasty and endovascular surgery. The pathogenesis of restenosis is multifactorial, involving such events as endothelial injury, inflammation, platelet activation, and hyperplasia of the intima, primarily due to vascular smooth muscle cell replication (vSMC). The incidence of intimal hyperplasia varies in different risk populations, e.g., diabetic patients, up to 35% of whom require bare metal stent implantation; clinical evidence has shown that this value is reduced but continues to cause pro

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16

Cole, Jonathan Samuel. "Pulsatile, non-Newtonian blood flows through typical arterial bypass graft models." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326405.

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17

Hofstra, Leonard. "Intimal hyperplasia in human vascular grafts a study in peripheral bypasses and arteriovenous fistulas /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=7934.

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18

Robb, Tiffany Marie. "Immune Mechanisms of Extracellular Matrix Remodeling in the Common Carotid: A Model of Intimal Hyperplasia." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/228464.

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Intimal hyperplasia (IH) is characteristic of a cell population increase within the innermost layer of the arterial wall. It is hypothesized that extracellular matrix vascular remodeling secondary vascular injury is dependent upon the Th17 subset of the CD4+ lymphocytes. Male C57BL/6J and FVB/NJ murine strains underwent complete left common carotid artery ligation for periods of 14 and 28 days. A therapeutic simvastatin model was carried out in the FVB/NJ strain and involved a daily subcutaneous injection regimen of 40 mg/kg/mouse beginning 72 hours prior to and daily following a 14 day caroti

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19

Rocha, Laura de Andrade da. "Caracterização do perfil dos componentes do sistema das cininas, óxido nítrico e metaloproteinases como marcadores na reestenose precoce de stents revestidos pós angioplastia transluminal percutânea periférica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-20072016-115252/.

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Introdução: A reestenose pós tratamento endovascular de lesões ateroscleróticas em artérias periféricas é a principal desvantagem desta técnica minimamente invasiva. A inflamação vascular após angioplastia com balão e/ou implante de stent desempenha um papel importante na proliferação de células do músculo liso vascular e posterior crescimento de uma neoíntima, e vários marcadores inflamatórios têm sido referidos como potenciais preditores dessa complicação, porém os fatores que contribuem para a estenose intra-stent no segmento vascular periférico não foram completamente elucidados. Recenteme

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20

Bu, De-xiu. "The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-615-8/.

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21

Krishnan, Aadithya. "SIMVASTATIN INCORPORATED PERIVASCULAR POLYMERIC CONTROLLED DRUG DELIVERY SYSTEM FOR THE INHIBITION OF VASCULAR WALL INTIMAL HYPERPLASIA." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1186425531.

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22

Fouquet, Olivier. "Les greffons vasculaires en chirurgie coronaire Does a skeletonized internal thoracic artery give less postoperative complications than a non-skeletonized artery for patients undergoing surgery for coronary artery bypass?" Thesis, Angers, 2019. http://www.theses.fr/2019ANGE0039.

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L’utilisation de greffons artériels (Artère Thoracique Interne (Ati)) et/ou veineux est habituelle au cours de pontages coronaires.1) L’hyperplasie intimale (HI) d’une veine est un mécanisme adaptatif lorsque la veine est soumise à un flux artériel. Certaines solutions de conservation semblent limiter cette HI dans des études in vitro. 2) Deux types de circulation extra-corporelle (CEC) sont utilisables : CEC centrifuge dite non pulsée et CEC à galets dite pulsée. L’absence de pulsatilité est à l’origine d’une réaction inflammatoire systémique et créée une altération du tonus myogénique d’artè

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23

Olojugba, Deji H. "Clinical aspects of vein graft stenosis and the role of endothelin and its inhibitors in intimal hyperplasia." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29616.

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This thesis looks at clinical and biological aspects of vein graft stenoses in order to improve on existing management strategies and to explore the possibility for a new pharmacological therapy using antagonists of the endothelin system. After an overview of peripheral vascular disease, the introductory chapters discuss vein graft surveillance, intimal hyperplasia and properties of the vasoactive peptide, endothelin. The work described consists of clinical and laboratory based research. In the clinical chapters a retrospective study analysed the influence of patient factors on the outcome of

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24

Black, Melanie Kim. "The compounding effects of obesity on the development of Intimal Hyperplasia following vascular intervention : a histopathological analysis." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/2775.

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Includes abstract.<br>Includes bibliographical references (leaves 100-111).<br>This study examines the histopathological response to injury following both balloon angioplasty and endovascular stenting in the Zucker rat, a model that allows interpretation of the role of obesity as well as progressive glucose intolerance and hyperinsulimaemia. Lean and obese Zucker fatty rats and Zucker diabetic fatty rat (ZDF) were subjected to balloon injury with or without stenting. The development of IH, along with the histological response to injury was analyzed.

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25

Nishio, Hiroomi. "MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model." Kyoto University, 2019. http://hdl.handle.net/2433/242371.

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26

Beneli, Cristina Tonin. ""Hiperplasia intimal arterial decorrente de um modelo experimental de estenose aórtica intrínseca: estudo morfológico, morfométrico e ultraestrutural"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-22092006-114410/.

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O objetivo do presente trabalho foi avaliar a morfologia e a ultraestrutura da hiperplasia intimal arterial decorrente de um modelo de estenose aórtica experimental, através da inserção de um pino de acrílico no orifício da artéria renal esquerda. Realizamos um estudo morfológico e ultraestrutural em 64 ratos Wistar, machos, com peso médio de 250 g, divididos em 4 subgrupos de acordo com o dia da eutanásia (1, 7, 15 e 30 dias de pós-operatório). O segmento da aorta envolvendo o pino foi retirado e estudado com diferentes protocolos para: microscopia óptica de alta resolução, microscopia eletrô

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27

Campos, César Presto. "Estudo da perviedade e do perfil sérico de marcadores inflamatórios com uso de stents impregnados de carbono no território vascular periférico." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-25072018-103058/.

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Introdução: Um dos fatores mais comuns de falha do procedimento das angioplastias vasculares periféricas é a estenose recorrente (reestenose). A inflamação vascular após angioplastia e implante de stent desempenha papel importante na proliferação de células do músculo liso vascular e posterior crescimento de neoíntima hipertrófica. Diversos estudos têm sugerido que a superfície dos stents, quando impregnada com determinadas moléculas, pode limitar a reestenose de forma eficaz. O carbono diamante, polímero de hidrocarboneto amorfo, pode ser usado para essa finalidade, reduzindo liberação de íon

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28

Shukla, Nilima. "Pathophysiology and treatment of intimal hyperplasia and vein graft failure : a focus on risk factors, nitric oxide and oxidant stress." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397800.

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29

Anglin, Sandra Sophia Charmain. "The role of the local renin-angiotensin system in the development of fibrocellular intimal hyperplasia following balloon catheter-induced injury in the rat." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307441.

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30

Jackson, Mark John Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "A study of vein graft haemodynamics using computational fluid dynamics techniques." Awarded by:University of New South Wales, 2007. http://handle.unsw.edu.au/1959.4/38575.

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Atherosclerosis, the leading cause of mortality in Western societies, affects large elastic arteries, causing focal deposition of proliferative inflammatory and lipid-laden cells within the artery. Several risk factors have been causally implicated in the ???reaction to injury??? hypothesis first described by Ross in 1969. The ???injury??? sustained by endothelial cells may be either mechanical or chemical. Environmental factors have a role in the production of chemical agents that are injurious to the endothelium. Mechanical stresses such as wall tensile stress are proportional to systemic bl

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31

Beneli, Cristina Tonin. "Estudo da participação das metaloproteinases 2 e 9 no desenvolvimento da hiperplasia intimal decorrente de modelo experimental de estenose intrínseca da aorta." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-12012010-192629/.

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As metaloproteinases têm sido implicadas no desenvolvimento de hiperplasias intimais em diferentes situações. O objetivo do presente trabalho foi avaliar a participação das metaloproteinases 2 e 9 no desenvolvimento da hiperplasia intimal decorrente de modelo experimental de estenose intrínseca da aorta. Este modelo consiste na inserção de um pino acrílico na aorta de ratos. Foram utilizados 288 ratos Wistar machos, com peso médio de 250 g, os quais foram separados em quatro grupos: (1) controle sham-operado, (2) controle sham-operado tratado com doxiciclina, (3) estenosado e (4) estenosado tr

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32

Mauro, Maria Fernanda Zuliani. "Análise volumétrica da hiperplasia intimal intra-stent farmacológico em pacientes diabéticos tratados com ou sem cilostazol." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-04102013-090756/.

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Fundamentos: Ensaios prévios reunindo pacientes em series consecutivas ou randomicas sem cegamento evidenciaram beneficio da adição do cilostozol à terapia antiplaquetária em diabéticos submetidos ao implante de stents coronários farmacológicos com redução nas taxas de reestenose binária, perda tardia intra-stent e revascularização tardia da lesão alvo. Objetivos: O objetivo primário deste estudo foi verificar se a adição do cilostazol à dupla terapia antiplaquetária, proporcionaria uma redução adicional da hiperplasia intimal em diabéticos após o implante de stent farmacológico, mensurada por

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33

Li, Jun. "Pre-existing intimal hyperplasia and overexpression of TGF-ß1 in saphenous vein grafts before myocardial revascularization in humans: implications for aortocoronary saphenous vein graft disease." Ulm : Univ. Ulm , Med. Fak, 2001. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-8610.

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34

Stevenson, Mark Daniel. "Three-Dimensional Matrices Used to Characterize Cellular Behavior." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354643898.

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35

Kamann, Stefanie. "Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2013/6468/.

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Die Restenose stellt ein zentrales Problem der interventionellen Kardiologie dar und ist häufigste Komplikation nach perkutanen Angioplastieverfahren. Hauptursache dieser Wiederverengung des Gefäßes ist die Bildung einer Neointima durch die Proliferation transdifferenzierter vaskulärer glatter Muskelzellen und die Sekretion extrazellulärer Matrix. Die Entstehung reaktiver Sauerstoffspezies (ROS) und die Entzündungsreaktion nach der Gefäßverletzung werden als frühe, die Neointimabildung induzierende Prozesse diskutiert. Im Rahmen dieser Arbeit wurden mehrere Projekte bearbeitet, die Aufschluss

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36

Kaur, Kuljeet. "Synthesis, evaluation, and applications of hydrogen sulfide-releasing supramolecular materials." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/104204.

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H2S is a biologically relevant signaling gas that is endogenously produced throughout the body. The (patho)physiological roles of H2S have led researchers to develop various compounds that decompose to release H2S (H2S donors) for exogenous H2S administration. However, many small molecule H2S donors suffer from poor solubility, low stability, and lack of control over H2S release rates. As a result, there has been an increasing interest in utilizing supramolecular materials for exogenous H2S delivery. With growing potential applications of supramolecular H2S-releasing materials, it is importan

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37

Elesbão, João Luiz de Lara. "Análise morfométrica da carótida de suínos submetidos à angioplastia com implante de stent de cromo-cobalto." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/23010.

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OBJETIVO: analisar, por meio de morfometria digital, a reação intimal presente na artéria carótida de suínos submetidos à angioplastia isoladamente e à angioplastia seguida de implante de stent de cromo - cobalto. MATERIAIS E MÉTODOS: em oito suínos sadios foi realizada a angioplastia isolada da artéria carótida comum (ACC) direita e angioplastia com implante de um stent de cromo – cobalto expansível por balão na artéria carótida comum esquerda. Após período de quatro semanas, os animais foram submetidos à eutanásia para a retirada de amostras de tecido arterial e preparo de lâminas histológic

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AHMED, MOHAMED MOHAMED NORAH. "The innovation of Multilayered Aneurysm Repair Stents (MARS) in treatment of thoraco-abdominal aneurysms." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41912.

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Background Morbidity and mortality from Thoraco-abdominal aneurysms are tremendous. Preoperative assessment in predicting cardiac and pulmonary risk factors in order to reduce cardiopulmonary complications, paraplegia, and renal failure are the main determinants of postoperative mortality and therefore gained substantial attention during the last decades.(Jacobs MJ et al.,2007) Left heart by-pass, CSF drainage and epidural cooling have significantly reduced the paraplegia rates. Monitoring MEPs allowed detection of cord ischemia,(spinal cord ischemic injury, SCII) guiding aggressive surgical

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39

Pham, Dung. "Développement de bloqueurs de l'angiotensine II et de l'endothéline pour un traitement local de l'hyperplasie intimale dans le modèle de dommage vasculaire chez le rat et le furet." Thèse, Université de Sherbrooke, 2004. http://savoirs.usherbrooke.ca/handle/11143/4191.

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L’athérosclérose et ses complications demeurent une des causes majeures de décès dans les pays industrialisés. L’angioplastie coronarienne n’a pas cessé de progresser et atteint de hauts niveaux de réussite technique. Toutefois, des obstacles majeurs au succès à long terme de l'angioplastie persistent (Davies et Hagen, 1994). C’est le cas de la resténose. Plus de 30 à 60% des artères coronariennes ayant subies une angioplastie sont des cas de resténose, survenant durant la première année de la procédure (Kitazume et al, 1995). Plusieurs facteurs de risques menant vers la resténose post-angiopl

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40

Rückert, Ralph-Ingo. "Experimentelle und klinische Untersuchungen zur Optimierung der Hämodynamik in termino-lateralen Prothesenbypass-Anastomosen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13760.

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Die subendotheliale myointimale Hyperplasie (MIH) stellt eine der Hauptursachen für die Ausbildung von Stenosen und Verschlüssen im Bereich von Anastomosen dar. Besondere Bedeutung hat die MIH in termino-lateralen Anastomosen. An der Entstehung der MIH sind hämodynamische Faktoren entscheidend beteiligt. Ausgehend von der Annahme, daß eine Veränderung der Anastomosenform die Hämodynamik beeinflussen kann, wurde in der vorliegenden Arbeit eine neue Anastomosenform, die femorocrurale Patchprothese (FCPP), entwickelt mit dem Ziel einer Optimierung der Strömungsverhältnisse im Anastomosenbereich.

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Smirnova, Natalia. "Identification d'une nouvelle cible pour la prévention de la resténose intra-stent : la phosphoinositide 3-kinase gamma." Toulouse 3, 2013. http://www.theses.fr/2013TOU30136.

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L'angioplastie avec pose de stent est le traitement de prédilection de la plaque d'athérome symptomatique. Une complication fréquente de cette intervention est la resténose intra-stent qui mène à une nouvelle obstruction de la lumière artérielle. Cette pathologie repose sur le processus d'hyperplasie intimale, combinaison d'une inflammation locale et d'une modulation phénotypique des cellules musculaires lisses (CML) de la paroi artérielle. Afin de pallier à cette pathologie, les stents ont été recouverts d'agents anti-prolifératifs. Bien qu'efficace dans la prévention de la resténose, l'utili

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Grudtner, Marco Aurelio. "Análise histológica e histomorfométrica de carótidas após o implante de stent de cromocobalto sem e com revestimento de polímero : modelo experimental porcino." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/24269.

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Introdução: Apesar dos avanços significativos no tratamento endovascular das doenças arteriais coronarianas e periféricas, a reestenose intra-stent continua sendo o principal limitante a médio prazo desses procedimentos. O mecanismo da reestenose intra-stent é principalmente a hiperplasia intimal, já que o stent impede a retração elástica aguda e resiste ao remodelamento geométrico negativo tardio. A hiperplasia intimal ocorre basicamente em resposta à formação de trombo local, à inflamação e às dissecções intimais e mediais secundárias à injúria causada pelo stent, sendo o grau de resposta in

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Heise, Michael. "Der Einfluss der hydraulischen Impedanz auf die Prognose und lokale Hämodynamik femoro-infrainguinaler Rekonstruktionen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13922.

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Durch die intraoperative Anwendung der extrakorporalen Bypassflow-Messung wurde zum ersten Mal die Messung und Berechnung der hydraulischen Impedanz möglich. Von den in der vorgelegten Untersuchung berücksichtigten Variablen des hydraulischen Impedanzkonzeptes zeigte sich, dass die Phasenverschiebung zwischen Druck- und Flusskurven, gemessen als erster Impedanzphasenwinkel, die größte klinische Bedeutung hatte. Mit Hilfe der Phasenverschiebung wurde die Langzeitprognose von femoro-poplitealen und insbesondere cruralen Bypässen eindeutig vorhersagbar. Sämtliche Bypässe zu Ausstromgebieten, die

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Kokkalis, Efstratios. "Fluid dynamic assessments of spiral flow induced by vascular grafts." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/5b96492f-983f-4baa-8e48-20da6939e65c.

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Peripheral vascular grafts are used for the treatment of peripheral arterial disease and arteriovenous grafts for vascular access in end stage renal disease. The development of neo-intimal hyperplasia and thrombosis in the distal anastomosis remains the main reason for occlusion in that region. The local haemodynamics produced by a graft in the host vessel is believed to significantly affect endothelial function. Single spiral flow is a normal feature in medium and large sized vessels and it is induced by the anatomical structure and physiological function of the cardiovascular system. Grafts

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Harrington, Jennifer Jean. "Monitoring of vascular health in children at risk for atherosclerosis." Thesis, 2014. http://hdl.handle.net/2440/84913.

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Adult cardiovascular disease has its origins in childhood, and adolescence is a critical period in determining lifetime risk. Early changes in arterial structure and function measured non-invasively have prognostic significance. Assessment of vascular structure and function provide an opportunity to test intervention strategies at an age when vascular damage is potentially reversible. Understanding the relative sensitivity of these markers of vascular damage is essential in identifying children at risk and enabling evaluation of clinical and public health interventions. In a cross-sectional st

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Ma, Yu-Dong, and 馬郁東. "The role and underlying mechanism of pyrogallol and caveolin-1 on down-regulation of VSMC migration and intima hyperplasia in carotid ligation mouse model." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/33506614471642656100.

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碩士<br>國立東華大學<br>生物技術研究所<br>98<br>Caveolin-1 (Cav-1) is identified as the major unit forms scaffold structure, regulates several signaling pathway and abundantly expressed in vascular smooth muscle cell (VSMC). VSMC migration contributes to intimal hyperplasia, which is involved in several vascular diseases including atherosclerosis. Previous study demonstrated that Cav-1-deficient VSMC showed an abnormal increase in proliferation and migration rate as compared with wild-type. The mechanism of Cav-1 in VSMC proliferation is already demonstrated, but the role of Cav-1 in VSMC migration has not b

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Varga, Martin. "Allogenní štěp v rekonstrukční cévní chirurgii-použití imunosuprese v experimentu." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-322655.

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(ENGLISH) Background: The investigation of the immunosuppression usage in cardiovascular surgery and interventional cardiology is, at present, concentrated on three main topics: 1) influence on intimal hyperplasia of coronary and peripheral vascular reconstructions 2) influence on rejection of allogeneic vascular grafts and 3) influence on intimal hyperplasia of coronary arteries after endovascular interventions. Modern immunosuppressive drug FK506 (Tacrolimus) could have a positive effect for these indications. In experimental study, FK506 inhibited rejection of arterial allografts and also i

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Cheng, Ting-Tzu, and 鄭汀孜. "The role of cannabinoid system in the development of intimal hyperplasia on vessels after angioplasty injury." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/00492904163642238444.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>95<br>Abstract In ten major causes of the death in Taiwan, cardiovascular disease and hypertension are all relate to atherosclerosis. The main methods to treat coronary artery disease are percutaneous transluminal coronary angioplasty, with or without stent implantation. But within the following 6 months after the operation, nearly 30 - 50％ of the patients have coronary restenosis. Previously, reports showed that cannabinoid system might play a role in the treatment of atherosclerosis. Delta-9-tetrahydrocannabinol, or 6a, 7, 8, 10a-tetrahydro-6,6,9-trimethyl-3-pent

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Chen, Yi-Jen, and 陳倚蓁. "Paeonia suffruticosa Andr. inhibits aortic smooth muscle cell migration in vitro and intimal hyperplasia in vivo." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/y688xj.

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碩士<br>中國醫藥大學<br>中國藥學暨中藥資源學系碩士班<br>100<br>Cerebral and cardiovascular diseases are mainly caused by the pathogenesis of arterial vascular smooth muscle. Paeonia suffruticosa Andr. (abbreviated as PSex)is a well-known traditional Chinese herbal medicine. Ancient Chinese medicine literatures have showed that various effects of this herb on human sickness such as reducing heat, promoting blood flow and eliminating stasis. Paeonol (2′-hydroxy-4′-methoxyacetophenone) is one of the main components extracted from PSex. Paeonol was reported to have multi-biological activites such as anti-inflammatory,

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"Role of TRPM2 in neointimal hyperplasia, vascular smooth muscle cell migration and proliferation." 2013. http://library.cuhk.edu.hk/record=b5549799.

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血管內膜的進行性增厚是動脈粥樣硬化的重要標誌，並最終導致閉塞性血管病。血管內膜增生的一個主要因素是血管中膜的平滑肌細胞遷移至內膜層並增殖。大量研究證實，在動脈粥樣硬化的發生發展中，過量產生的活性氧簇（ROS）參與了血管壁的增厚。M型瞬時受體電位通道亞家族的成員TRPM2在血管平滑肌細胞中有表達，它能被ROS激活並對Ca²⁺通透，但其在血管平滑肌中的功能以及與心血管疾病的聯繫尚未見報道。<br>本論文著眼於探討TRPM2在鼠和人血管內膜增生中的作用。用血管外周套管法建立在體齧齒類動脈內膜增生模型。套管放置2周後，大鼠股動脈可見明顯的內膜增厚。免疫染色顯示新生內膜及其鄰近中膜區域內有大量增殖細胞核抗原陽性細胞，提示在增生的動脈中，細胞週期活動增強。動脈內膜和中膜内二氫乙錠螢光信號顯著增強，提示了ROS的過量生成。免疫染色和免疫印跡法均顯示，套管損傷導致TRPM2表達上調。免疫螢光雙標TRPM2與α-平滑肌肌動蛋白顯示內膜區域有大量TRPM2陽性的平滑肌細胞。與正常股動脈中膜平滑肌細胞相比，次黃嘌呤和黃嘌呤氧化酶在套管損傷的動脈來源的新生內膜平滑肌細胞中引起更大幅度的細胞內鈣離子濃度升高，而TRPM2抑制性抗體TM2E3預處理可消除這種差異。套管放置3周可引起小鼠頸動脈新生內膜形成，並伴隨著TRPM2表達上調。敲除TRPM2基因可顯著抑制內膜增生。取冠狀動脈搭橋術後殘餘的大隱靜脈，離體培

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