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Journal articles on the topic 'Intima Hyperplasia'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Yan, Huifang, Xiwei Peng, Hao Xu, Jiahuan Zhu, and Changqing Deng. "Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination." Evidence-Based Complementary and Alternative Medicine 2018 (August 13, 2018): 1–15. http://dx.doi.org/10.1155/2018/1508637.

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VSMC proliferation and ECM deposition always resulted in intimal hyperplasia. Astragalus–Angelica combination has a protective effect on the cardiovascular system. The inhibition effect of different Astragalus–Angelica combination on the hyperplastic intima after vascular balloon injury in rats was investigated in this study. Astragalus–Angelica combination can inhibit the intima hyperplasia after balloon injury, in which a 1:1 ratio shows excellent results. Astragalus–Angelica combination can enhance the expression of smooth muscleα-actin (SMа-actin) and inhibit the expression of proliferatin

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Mesfin, G. M., M. J. Higgins, W. P. Brown, and D. Rosnick. "Cardiovascular Complications of Chronic Catheterization of the Jugular Vein in the Dog." Veterinary Pathology 25, no. 6 (1988): 492–502. http://dx.doi.org/10.1177/030098588802500613.

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Cardiovascular changes associated with indwelling catheters were evaluated in 51 adult beagle dogs catheterized for 4 to 9 weeks. Pathologic changes consistent with traumatic injury were in the vena cava and endocardium of the right atrium of 88% of cannulated dogs. Lesions were characterized by surface denudation and diffuse intimal thickening due to myointimal hyperplasia and deposition of extracellular matrix. Affected intima was lined by hyperplastic, poorly differentiated endothelial cells and contained round to oval cells with characteristics of smooth muscle cells. After 9 weeks, thicke

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Jalaeefar, Amirmohsen, Arash Mohammadi Tofigh, Atoosa Gharib, Mohsen Khandaghy, and Mohammad Reza Rahimi. "Effects of N-acetylcysteine on arterial neo-intimal hyperplasia in rat model of arteriovenous fistula." Journal of Vascular Access 20, no. 2 (2018): 190–94. http://dx.doi.org/10.1177/1129729818793368.

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Introduction: Arteriovenous fistula is the best choice for vascular access in hemodialysis patients. However, arteriovenous fistula dysfunction is a major clinical issue. The most common cause of arteriovenous fistula failure is intimal hyperplasia. In this study, we have investigated the effect of N-acetylcysteine on neo-intimal hyperplasia after arteriovenous fistula creation in rats. Methods: This study was conducted in 24 rats which were randomly divided into two groups: control and N-acetylcysteine groups. An end-to-side anastomosis was made between the femoral artery and vein. The contro

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Van Phung, Doan, Takeshi Kinoshita, Tohru Asai, and Tomoaki Suzuki. "Histological and Morphometric Properties of Skeletonized Gastroepiploic Artery and Risk Factors for Intimal Hyperplasia." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 7, no. 3 (2012): 191–94. http://dx.doi.org/10.1097/imi.0b013e318264f4cb.

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Objective The aim of the present study was to examine the histological and morphometric properties of skeletonized gastroepiploic artery (GEA) and the risk factors for intimal hyperplasia. Methods We obtained the redundant distal segments of skeletonized GEAs from 33 patients undergoing coronary bypass surgery and microscopically examined the transverse sections just distal to the most distal anastomoses. Intimal hyperplasia was evaluated on the basis of intima-to-media ratio and percentage of luminal narrowing. Risk factors were examined using multivariate linear regression analysis. Results

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Hirai, T., Y. Korogi, M. Harada, and M. Takahashi. "Prevention of Intimal Hyperplasia by Irradiation." Acta Radiologica 37, no. 1P1 (1996): 229–33. http://dx.doi.org/10.1177/02841851960371p147.

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Purpose: This experimental study was designed to investigate the effect of irradiation in prevention of intimal hyperplasia. Material and Methods: Twenty rabbits were divided into 4 groups, which were irradiated with 2, 5, 10, and 20 Gy, respectively. The intima of both femoral arteries was injured by air-drying, and irradiation was performed on the unilateral side. The contralateral femoral artery served as a control. Angiograms as well as histologic specimens were obtained 1 month later. Results: Marked intimal hyperplasia was observed in all control sites. There were no significant differen

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ARPA, Abdurrahman, and Pınar AYDIN OZTURK. "Histopathological effects of nimodipine and pentoxifylline on the vessel wall in end-to-end anastomoses in rat carotid arteries." Journal of Experimental and Clinical Medicine 39, no. 3 (2022): 879–83. http://dx.doi.org/10.52142/omujecm.39.3.54.

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When reperfusion following ischemia occurs, oxygen returns to the ischemic tissue, increasing free oxygen radicals and inducing paradox secondary damage. Before infarction, revascularization may influence the morbidity rate. Successful revascularization is not always achieved due to stenosis incidence, proliferation of smooth muscle cells, and intimal hyperplasia. This study compares the effects of nimodipine that prevents vasospasm and pentoxifylline, which stimulates growth factors and reduces collagen synthesis on intimal hyperplasia. Eighteen randomly selected Sprague-Dawley rats were divi

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Kachlik, David, Vaclav Baca, Petr Fara, et al. "Blood vessels of the normal and pathologically changed wall of the human vena saphena magna." Open Medicine 3, no. 4 (2008): 475–81. http://dx.doi.org/10.2478/s11536-008-0047-5.

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AbstractThe vascular supply of the wall of human vena saphena magna was qualitatively studied by the use of several morphological methods on both normal and pathologically changed veins. The material was obtained from patients undergoing aortocoronary bypass or surgery of the varices, and material from cadavers. Under physiological conditions, the wall of vena saphena magna is supplied by delicate system of vasa vasorum, organized in a form of feeding vessels branched into an irregular loose adventitial mesh and continuing further as a microcirculatory network supplying the two outer thirds of

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Qian, Kun, Li Feng, Yujie Sun та ін. "Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model". BioMed Research International 2018 (12 липня 2018): 1–9. http://dx.doi.org/10.1155/2018/8973986.

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Inhibiting vascular endothelial foam is the focus of clinical attention. Using SonoVue (an ultrasound contrast agent), the salusin-α gene was transfected into the arterial intima of an atherosclerotic rabbit model induced by a high-fat diet in this study. Subsequently the model of blood lipid indexes, the pathological structure of the intima, and changes in molecules regulating atherosclerosis were investigated. The high-density lipoprotein C and apolipoprotein A values in the salusin-α gene overexpression (P) group were higher than those in the salusin-α gene interference (RP) group (P < 0

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Vazquez-Padron, Roberto I., Juan C. Duque, Marwan Tabbara, Loay H. Salman, and Laisel Martinez. "Intimal Hyperplasia and Arteriovenous Fistula Failure: Looking Beyond Size Differences." Kidney360 2, no. 8 (2021): 1360–72. http://dx.doi.org/10.34067/kid.0002022021.

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AbstractThe development of venous intimal hyperplasia (IH) has been historically associated with failure of arteriovenous fistulas (AVFs) used for hemodialysis. This long-standing assumption, made on the basis of histologic observations, has been recently challenged by clinical studies indicating that the size of the intima by itself is not enough to explain stenosis or AVF maturation failure. Irrespective of this lack of association, IH is present in most native veins and fistulas, is prominent in many patients, and suggests a role in the vein that may not be reflected by its dimensions. Ther

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Mitra, Amit K., Michael G. Del Core, and Devendra K. Agrawal. "Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies." Canadian Journal of Physiology and Pharmacology 83, no. 8-9 (2005): 701–15. http://dx.doi.org/10.1139/y05-080.

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Atherosclerosis and restenosis are the result of vascular injury followed by an inflammatory and fibroproliferative response that involves a large number of growth factors, cytokines, and cellular elements. Platelet activation and leukocyte recruitment into the arterial intima play a crucial role, initiating a whole spectrum of reactions leading to vascular smooth muscle cell hyperplasia and intimal migration. The roles of macrophages and lymphocytes and mast cells as mediators of inflammation and immune response is discussed, as are the roles of growth factors and cytokines. New light on the

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Galarza-Delgado, D. Á., J. R. Azpiri-López, I. J. Colunga-Pedraza, et al. "AB1212 PREVALENCE OF CAROTID SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH PSORIATIC ARTHRITIS VS RHEUMATOID ARTHRITIS: A CASE CONTROL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1897. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5197.

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Background:Rheumatic diseases such as Psoriatic Arthritis (PsA) and Rheumatoid Arthritis (RA) are associated with increased morbidity and mortality, mainly due to cardiovascular causes. Cardiovascular outcomes in patients with PsA and RA cannot be completely explained by traditional cardiovascular risk factors, suggesting that the systemic inflammation that characterizes these diseases may have an important role on accelerated atherosclerosis.1Objectives:To compare carotid intima-media thickness (cIMT) and asymptomatic carotid plaque (CP) prevalence, between patients with PsA, RA and controls.

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Aydin, Unal, Murat Ugurlucan, Funda Gungor, et al. "Effects of Atorvastatin on Vascular Intimal Hyperplasia: An Experimental Rodent Model." Angiology 60, no. 3 (2008): 370–77. http://dx.doi.org/10.1177/0003319708321102.

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Introduction Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. Materials and methods Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed. Results Atorvastatin administration significantly lowered tota

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Karagöz, Uğur. "Inhibitory effect of cilostazol on intimal hyperplasia and smooth muscle cell proliferation in a rabbit carotid artery anastomosis model." Cardiovascular Surgery and Interventions 10, no. 2 (2023): 103–8. http://dx.doi.org/10.5606/e-cvsi.2023.1481.

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Objectives: This study aims to investigate the effect of cilostazol on intimal hyperplasia and smooth muscle cell proliferation in a rabbit carotid artery anastomosis model. Materials and methods: A total of 16 New Zealand male rabbits weighing 2 to 3 kg were used in this study. The rabbits were divided into two groups with eight in each group as Group A and Group B. A vertical neck incision was made in an appropriate position for all group rabbits and the right carotid artery was dissected. The same artery was transected and anastomosis using 8/0 polypropylene was performed with a continuous

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Sakarya, Ahmet, Hakan Uzun, Ayten Türkkanı, et al. "Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat." Journal of Reconstructive Microsurgery 35, no. 04 (2018): 244–53. http://dx.doi.org/10.1055/s-0038-1672130.

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Background The use of caffeine is not recommended prior to elective microsurgery due to its demonstrated negative effects on vessel anastomosis by the presumed sympathomimetic induction of vasoconstriction. In this study, we aimed to elucidate the systemic and local effects of caffeine on vessel diameter, anastomosis patency, and degree of intimal hyperplasia during the healing process. Methods Twenty-five rats were randomly assigned to five groups: (1) negative control, (2) preoperative systemic caffeine, (3) postoperative systemic caffeine, (4) perioperative systemic caffeine, and (5) a loca

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Kemahli, Mustafa Baris, Tugra Gencpinar, Huseyin Dursun, et al. "Effects Of Rivaroxaban And Apixaban On Intimal Hyperplasia In Rabbits." Turkish Journal of Vascular Surgery 31, no. 3 (2022): 148–56. http://dx.doi.org/10.9739/tjvs.2022.09.03.

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Aim: Intimal hyperplasia causes vascular occlusion and its optimal treatment is unknown. In this study, we evaluated the effectiveness of Apixaban and Rivaroxaban treatment for preventing intimal hyperplasia in rabbits. Material and Methods: The rabbits (n = 15) were randomly divided into three groups. Reanastomoses are applied to the carotid artery. All groups received 100 U/kg heparin sodium during the operation period. Group A (n = 5) as a control group had no medication. Group B (n = 5) was given Rivaroxaban 3 mg/kg/day. In-group C (n = 5) Apixaban was administered per orally 10 mg/kg. At

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Habibie, Yopie Afriandi, Dessy Rakhmawati Emril, Azharuddin, and Dedy Syahrizal. "Optimization of a local type rabbit model for arteriovenous fistula, focused on study neointimal hyperplasia." Bali Medical Journal 12, no. 2 (2023): 1426–30. http://dx.doi.org/10.15562/bmj.v12i2.4459.

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Link of Video Abstract: https://youtu.be/8kcI8mX5A6Y Background: Hemodialysis vascular access dysfunction is a significant cause of morbidity and mortality in hemodialysis patients. Over the past decades, numerous animal models have been developed. However, there needs to be more animal model protocol with rabbits to investigate neointimal hyperplasia in the arteriovenous fistula. This study aimed to explore an alternative rabbit model using a wild-type local model for investigating neointimal hyperplasia in the arteriovenous fistula. Methods: One local-type male rabbit performed arteriovenous

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Asfar, Sami, Ali Shuaib, Fatemah Al-Otaibi, Sora S. Asfar, and Narayana Kilarkaje. "A New Technique to Induce Experimental Myointimal Hyperplasia." Medical Principles and Practice 27, no. 5 (2018): 415–19. http://dx.doi.org/10.1159/000492575.

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Background: Arterial myointimal hyperplasia (MIH) has a significant impact on the long-term outcomes of vascular procedures such as bypass surgery and angioplasty. In this study, we describe a new and innovative technique to induce MIH using a dental flossing cachet in Wistar rats. Methods: The intimal damage in the common carotid artery was induced by inserting the tip of the dental flossing cachet through the external carotid artery into the common carotid artery and turning it on for 3 rounds of 20 s each (n = 10). After 2 weeks, the rats were anesthetized and the common carotid arteries of

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Zhang, Dechuan, Tieying Yin, Feifei Du, et al. "EVALUATION OF INTIMAL HYPERPLASIA AND THROMBOSIS AFTER IMPLANTATION OF PLATELET GLYCOPROTEIN IIIa MONOCLONAL ANTIBODY-ELUTING STENT IN NEW ZEALAND WHITE RABBIT AORTA OR ILIAC ARTERIES." Biomedical Engineering: Applications, Basis and Communications 27, no. 05 (2015): 1550046. http://dx.doi.org/10.4015/s1016237215500465.

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Since the percutaneous coronary intervention (PCI) was first introduced into China in 1984, this procedure has become widely accepted as an important step in coronary revascularization. This study aims to evaluate intimal hyperplasia and thrombosis after implantation of platelet glycoprotein IIIa monoclonal antibody (mAb)-eluting stent in the New Zealand white rabbit abdominal aorta or iliac artery by comparing CT angiography and pathological experiments. The antibody-eluting stents were prepared by the passive absorption method. Arterial intima in the stented segment and 0.5 cm adjacent to th

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Stolic, Radojica. "Dysfunction of the arteriovenous fistula for hemodialysis as a consequence of venous neointimal hyperplasia and treatment strategies." Srpski arhiv za celokupno lekarstvo 147, no. 9-10 (2019): 642–48. http://dx.doi.org/10.2298/sarh180413020s.

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One of the main problems related to inadequate planning of vascular access is dysfunction during maturation. Arteriovenous fistula dysfunction is most often a consequence of neointimal hyperplasia. Important causes for initial dysfunction of the fistula include narrow lumens of the arteries and veins used for anastomosis, damage to the vascular endothelium during fistula creation, previous venipuncture, postoperative development of venous collaterals, the impact force of friction on the arteriovenous anastomosis, a genetic predisposition for development of vascular stenosis, neointimal hyperpl

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Hollingsworth, S. J., C. B. Tang, and S. G. E. Barker. "The Effects of Heparin on Cultured Explants of Varicose Long Saphenous Vein." Phlebology: The Journal of Venous Disease 16, no. 2 (2001): 60–67. http://dx.doi.org/10.1177/026835550101600203.

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Objective: To examine the effects of heparin on smooth muscle cells (SMCs) in explants of varicose, long saphenous vein (LSV). Procedures: Explants of varicose LSV were cultured for 7 days either alone, or with heparin at 10, 100 or 1000 IU/ml (Monoparin). At 7 days, cultured explants were analysed for changes in intimal and medial thickness and by immuno-histochemistry. Comparisons were made with explants at initial isolation and with similar, cultured explants of normal LSV. Results: In normal LSV, by day 7, SMC-derived neo-intimal hyperplasia developed ( p<0.01) with an increase in intim

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Hariri, R. J., D. R. Alonso, D. P. Hajjar, D. Coletti, and M. E. Weksler. "Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury." Journal of Experimental Medicine 164, no. 4 (1986): 1171–78. http://dx.doi.org/10.1084/jem.164.4.1171.

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Old Fischer 344 rats are more susceptible to vascular lesions after arterial endothelial injury than are young animals. Thus, 20-26-mo-old Fischer 344 rats developed greater and more persistent intimal proliferative lesions than did 2-5-mo-old rats after aortic endothelial denudation. 3 d after deendothelialization, intimal thickness was increased two-fold in both old and young animals. However, 14 d after endothelial injury, intimal thickness had increased nearly five times in old animals, but had regressed to normal in young animals. Intimal thickness of young aortic grafts transplanted into

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Chang, Hong, Huan Lei, Yizhou Zhao, et al. "Yiqihuoxuejiedu Formula Restrains Vascular Remodeling by Reducing the Inflammation Reaction and Cx43 Expression in the Adventitia after Balloon Injury." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/904273.

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Vascular remodeling is closely related to hypertension, atherosclerosis, and restenosis after PCI. Considerable evidence indicates that the activation and proliferation of adventitial fibroblasts play key roles in vessel injury. The inflammatory response and high expression of connexins contribute to adventitial remodeling. Therefore, reducing inflammation reaction and connexins expression in adventitia may become a new target to prevent vascular remodeling. Yiqihuoxuejiedu formula, composed of TCM therapeutic principle of supplementing qi, activating blood and detoxification, can inhibit rest

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Wang, Yung-Chun, Dunpeng Cai, Xiao-Bing Cui, Ya-Hui Chuang, William P. Fay, and Shi-You Chen. "Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization—Brief Report." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 6 (2021): 2019–26. http://dx.doi.org/10.1161/atvbaha.121.316293.

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Objective: The objective of this study is to determine the role of JAK3 (Janus kinase 3) in reendothelialization after vascular injury. Methods and Results: By using mouse carotid artery wire injury and rat balloon injury model, we found that JAK3 regulates reendothelialization and endothelial cell proliferation after vascular injury. JAK3 and phospho-JAK3 levels were increased in neointimal smooth muscle cells in response to vascular injury in mice. JAK3 deficiency dramatically attenuated the injury-induced intimal hyperplasia in carotid arteries of both male and female mice. Importantly, JAK

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Liu, Chengwei, Xuesong Zhang, Shi Wang, et al. "Transfected Early Growth Response Gene-1 DNA Enzyme Prevents Stenosis and Occlusion of Autogenous Vein GraftIn Vivo." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/310406.

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The aim of this study was to detect the inhibitory action of the early growth response gene-1 DNA enzyme (EDRz) as a carrying agent by liposomes on vascular smooth muscle cell proliferation and intimal hyperplasia. An autogenous vein graft model was established. EDRz was transfected to the graft vein. The vein graft samples were obtained on each time point after surgery. The expression of the EDRz transfected in the vein graft was detected using a fluorescent microscope. Early growth response gene-1 (Egr-1) mRNA was measured using reverse transcription-PCR andin situhybridization. And the prot

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Costa, Regina de Faria Bittencourt da, Djalma José Fagundes, Yara Juliano, Neil Ferreira Novo, and Wilma Therezinha Trench Vieira. "Effects of external gamma radiation on femoral artery reimplantation in rats: morphometrical analyzes." Acta Cirurgica Brasileira 18, no. 2 (2003): 86–96. http://dx.doi.org/10.1590/s0102-86502003000200004.

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PURPOSE: To investigate the effects of external gamma radiation on rat femoral artery reimplant. METHODS: Sixty-two male Wistar rats were distributed in two groups I (Control) and II (Irradiated), both formed by three observation subgroups: 2 (10 animals), 7 (11) and 21(10) postoperative days (PO). The right femoral artery of each animal was split up and reimplanted (end-to-end anastomosis), through microsurgery technique. In the first PO day group II animals were irradiated with a single dose of 15Gy, external source. The histological analysis, qualitative and descriptive analysis, was accomp

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Tatic, Vujadin, Vladimir Kanjuh, Sasa Rafajlovski, Dusan Suscevic, and Radoje Ilic. "Morphological changes in aorto-coronary vein graft: The analysis of autopsy and biopsy material." Vojnosanitetski pregled 61, no. 5 (2004): 499–506. http://dx.doi.org/10.2298/vsp0405499t.

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Background. Patients with implanted aortic coronary grafts have different survival time, which raises the question why the efficacy of graft implants is so poor. The aim of this study was to present the results of the analysis of morphological changes in the vein grafts taken after the death of patients who died after surgery in different time intervals, as well to present the analysis of the grafts obtained after surgical reintervention. Methods. The total number of 656 grafts of 308 dead patients was analyzed, as well as 76 grafts from 40 patients who underwent surgical reintervention. Accor

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Kachlík, Stingl, Sosna, et al. "Morphological features of vasa vasorum in pathologically changed human great saphenous vein and its tributaries." Vasa 37, no. 2 (2008): 127–36. http://dx.doi.org/10.1024/0301-1526.37.2.127.

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Background: The question whether the primary increase of vasa vasorum (VV) of venous wall (i) plays an initial role in varicogenesis or (ii) is an expression of impairment of the nutritional conditions in superficial veins of lower extremities is not unambiguously solved yet. The aim of the study was to describe the arrangement of the VV within the wall of the human great saphenous vein (GSV) qualitatively, and of its tributaries at different stages of varicosis and in other pathological states like thrombophlebitis or phlebosclerosis. Material and methods: 22 patients deserving an aorto-coron

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Cherian, S. M., Y. V. Bobryshev, S. J. Inder, et al. "Involvement of Dendritic Cells in Long-Term Aortocoronary Saphenous Vein Bypass Graft Failure." Cardiovascular Surgery 7, no. 5 (1999): 508–18. http://dx.doi.org/10.1177/096721099900700507.

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Antigen-presenting dendritic cells are present in atherosclerotic lesions in human arterial intima, but have not been investigated in atherosclerotic and hyperplastic stenotic lesions that affect vein grafts used as arterial conduits. This study was undertaken to examine whether dendritic cells are present in aortocoronary artery saphenous vein bypass grafts affected by high-grade atheromatous stenosis. Stenotic saphenous vein coronary artery bypass grafts (angiographic luminal stenosis > 75%) were harvested from 10 patients (nine male, one female), aged 42–71 years (mean 56.5) at re-do ope

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Gregory, Elaine K., Antonio R. Webb, Janet M. Vercammen, Megan E. Flynn, Guillermo A. Ameer, and Melina R. Kibbe. "Periadventitial atRA citrate-based polyester membranes reduce neointimal hyperplasia and restenosis after carotid injury in rats." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 10 (2014): H1419—H1429. http://dx.doi.org/10.1152/ajpheart.00914.2013.

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Oral all-trans retinoic acid (atRA) has been shown to reduce the formation of neointimal hyperplasia; however, the dose required was 30 times the chemotherapeutic dose, which already has reported side effects. As neointimal formation is a localized process, new approaches to localized delivery are required. This study assessed whether atRA within a citrate-based polyester, poly(1,8 octanediolcitrate) (POC), perivascular membrane would prevent neointimal hyperplasia following arterial injury. atRA-POC membranes were prepared and characterized for atRA release via high-performance liquid chromat

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Pei, Fang, Hua Pei, Chunhua Su та ін. "Fisetin Alleviates Neointimal Hyperplasia via PPARγ/PON2 Antioxidative Pathway in SHR Rat Artery Injury Model". Oxidative Medicine and Cellular Longevity 2021 (21 квітня 2021): 1–15. http://dx.doi.org/10.1155/2021/6625517.

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The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. Fisetin, a plant flavonoid polyphenol, has been reported to be antioxidative and potent senolytic. It is unknown whether fisetin would inhibit neointimal hyperplasia. Theref

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Jahan, Reza, Timothy D. Solberg, Daniel Lee, et al. "Stereotactic Radiosurgery of the Rete Mirabile in Swine: A Longitudinal Study of Histopathological Changes." Neurosurgery 58, no. 3 (2006): 551–58. http://dx.doi.org/10.1227/01.neu.0000197335.93538.bd.

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Abstract OBJECTIVE: Stereotactic radiosurgery is an established, effective treatment for brain arteriovenous malformations. The mechanisms of vessel occlusion in arteriovenous malformations has not been extensively evaluated. To better understand these mechanisms, we report histopathological changes in the swine rete mirabile after stereotactic radiosurgery. METHODS: Thirty-five swine were used, 15 as nonradiated controls and 20 as radiated. Two in the control group and five in the radiated group were sacrificed before the study endpoint. Tissue was obtained from 13 nonradiated (4 at 3 mo, 5 a

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Baeza, Ciro, Marta Ribagorda, Carla Maya-Lopez, et al. "NIK Is a Mediator of Inflammation and Intimal Hyperplasia in Endothelial Denudation-Induced Vascular Injury." International Journal of Molecular Sciences 25, no. 21 (2024): 11473. http://dx.doi.org/10.3390/ijms252111473.

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Neointimal hyperplasia is the main cause of vascular graft failure in the medium term. NFκB is a key mediator of inflammation that is activated during neointimal hyperplasia following endothelial injury. However, the molecular mechanisms involved in NFκB activation are poorly understood. NFκB may be activated through canonical (transient) and non-canonical (persistent) pathways. NFκB-inducing kinase (NIK, MAP3K14) is the upstream kinase of the non-canonical pathway. We have now explored the impact of NIK deficiency on neointimal hyperplasia following guidewire-induced endothelial cell injury a

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Chen, Yuh-Fung, Kuo-Jen Wu, Lian-Ru Siao, and Huei-Yann Tsai. "Trilinolein, a Natural Triacylglycerol, Protects Cerebral Ischemia through Inhibition of Neuronal Apoptosis and Ameliorates Intimal Hyperplasia via Attenuation of Migration and Modulation of Matrix Metalloproteinase-2 and RAS/MEK/ERK Signaling Pathway in VSMCs." International Journal of Molecular Sciences 23, no. 21 (2022): 12820. http://dx.doi.org/10.3390/ijms232112820.

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Cerebrovascular disease is one of the leading causes of disability and death worldwide, and seeking a potential treatment is essential. Trilinolein (TriL) is a natural triacylglycerol presented in several plants. The effects of TriL on cerebrovascular diseases such as cerebral ischemia and carotid stenosis have never been studied. Accordingly, we investigated the protection of TriL on cerebral ischemia/reperfusion (I/R) and vascular smooth muscle cell (VSMC) migration in vivo and in vitro. The cerebral infarction area, the intima to media area (I/M ratio), and proliferating cell nuclear antige

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Szabo, Balazs, Balazs Gasz, Laszlo Adam Fazekas, et al. "Heterogeneous Maturation of Arterio-Venous Fistulas and Loop-Shaped Venous Interposition Grafts: A Histological and 3D Flow Simulation Comparison." Biomedicines 10, no. 7 (2022): 1508. http://dx.doi.org/10.3390/biomedicines10071508.

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Vascular graft maturation is associated with blood flow characteristics, such as velocity, pressure, vorticity, and wall shear stress (WSS). Many studies examined these factors separately. We aimed to examine the remodeling of arterio-venous fistulas (AVFs) and loop-shaped venous interposition grafts, together with 3D flow simulation. Thirty male Wistar rats were randomly and equally divided into sham-operated, AVF, and loop-shaped venous graft (Loop) groups, using the femoral and superficial inferior epigastric vessels for anastomoses. Five weeks after surgery, the vessels were removed for hi

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Toshmatova, Mahfuza, Sentaro Nakanishi, Yukiharu Sugimura, et al. "Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses." Materials 12, no. 20 (2019): 3351. http://dx.doi.org/10.3390/ma12203351.

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Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we examined surface coating with laminin in a standardized rat implantation model. Detergent-decellularized aortic grafts from donor rats (n = 37) were coated with laminin and systemically implanted into Wistar rats. Uncoated implants served as controls. Implant re-colonization and remodeling were examined by scanning electron microscopy (n = 10), histology and immu

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Grudzinska, Monika K., Krzysztof Bojakowski, Joanna Soin, Frank Stassen, Cecilia Söderberg-Nauclér, and Piotr Religa. "RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima." Herpesviridae 1, no. 1 (2010): 7. http://dx.doi.org/10.1186/2042-4280-1-7.

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Bodnar, P. Ya. "Structural features of the lower limb deep vein remodeling as a morphologic component in the pathogenesis of pulmonary thromboembolism in cancer patients." Reports of Morphology 25, no. 4 (2019): 11–16. http://dx.doi.org/10.31393/morphology-journal-2019-25(4)-02.

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Oncological patients are at high risk of developing thromboembolic complications, which is a manifestation of a complex set of symptoms – cancer. At the same time, the analysis of the literature shows that the question of the involvement of structural changes of the vascular wall in the pathogenesis of possible primary thrombus formation in cancer patients remains open. The aim of the study – to study the structural features of remodeling of the deep vein of the lower extremity as a morphological link of pathogenesis of pulmonary embolism in cancer patients. Retrospective analysis of 54 protoc

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Kim, Jung-Hwan, Eui Hwa Jang, Ji-Yeon Ryu, et al. "Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model." International Journal of Molecular Sciences 24, no. 4 (2023): 3306. http://dx.doi.org/10.3390/ijms24043306.

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We investigated the role of a sirolimus-embedded silk microneedle (MN) wrap as an external vascular device for drug delivery efficacy, inhibition of neointimal hyperplasia, and vascular remodeling. Using dogs, a vein graft model was developed to interpose the carotid or femoral artery with the jugular or femoral vein. The control group contained four dogs with only interposed grafts; the intervention group contained four dogs with vein grafts in which sirolimus-embedded silk-MN wraps were applied. After 12-weeks post-implantation, 15 vein grafts in each group were explanted and analyzed. Vein

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Planas-Rigol, Ester, Nekane Terrades-Garcia, Marc Corbera-Bellalta, et al. "Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis." Annals of the Rheumatic Diseases 76, no. 9 (2017): 1624–34. http://dx.doi.org/10.1136/annrheumdis-2016-210792.

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BackgroundGiant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function.ObjectiveTo investigate whether ET-1 induces a migratory myofibroblastic phenotype in human TA-derived vascular smooth muscle cells (VSMC) leading to intimal hyperplasia and vascular occlusion in GCA.Method

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Mullakhmetov, Rafael M., Mikhail V. Plotnikov, Elena E. Fomina, and Aleksandr V. Maksimov. "ULTRASOUND FINDINGS IN THE EARLY AND LONG-TERM PERIOD AFTER CAROTIDS ENDARTERECTOMY." Acta medica Eurasica, no. 2 (June 25, 2024): 19–26. http://dx.doi.org/10.47026/2413-4864-2024-2-19-26.

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Carotid endarterectomy is an effective method of primary and secondary prevention of acute cerebrovascular accident. However, surgical intervention is associated with a risk of acute cerebrovascular accident of up to 3% in asymptomatic and up to 6% in symptomatic patients, and in the long-term period after surgical treatment, there are risks of developing repeated stenoses in the reconstruction area. Object. To identify pathological ultrasound phenomena in the reconstruction area in the early and long-term period after carotid endarterectomy. Materials and methods. A retrospective analysis of

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Mejia-Vilet, J. M., Y. J. López-Hernández, J. I. Santander-Vélez, et al. "Angiotensin II receptor agonist antibodies are associated with microvascular damage in lupus nephritis." Lupus 29, no. 4 (2020): 371–78. http://dx.doi.org/10.1177/0961203320904787.

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Angiotensin II type 1 receptor agonist antibodies (AT1R-AAs) have been associated with hypertension, atherosclerosis and vascular inflammation in human diseases. The aim of the study was to evaluate the prevalence of AT1R-AAs in active lupus nephritis (LN) patients and their association with vascular damage. One hundred and seven active LN patients underwent a complete clinical examination, measurement of AT1R-AAs, ambulatory blood pressure monitoring, carotid intima-media thickness measurement and morphometric analysis of subintimal fibrosis and medial hyperplasia of the vessels in the kidney

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Albayrak, Gokhan, Erdem Silistreli, Bekir Ergur, et al. "Inhibitory effect of adenosine on intimal hyperplasia and proliferation of smooth muscle cells in a carotid arterial anastomosis animal model." Vascular 23, no. 2 (2014): 124–31. http://dx.doi.org/10.1177/1708538114533962.

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Purpose The effect of adenosine (9-β-0-ribifuranosyladenine) on the endothelial cell proliferation and neointimal hyperplasia is investigated in the rabbit carotid artery anastomosis model. Methods Twenty-eight New Zealand white rabbits were arranged in four groups of seven animals each. The right carotid arteries of each animal were transsected and re-anastomosed. The left sides remained as control. In Group A, no medication was used. In Group B, subcutaneous Adenosine was applied for 3 days. In Group C, the same dose was applied for 7 days, and in Group D for 21 days. After 28 days, the lumi

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Kural, Mehmet H., Guohao Dai, Laura E. Niklason, and Liqiong Gui. "An Ex Vivo Vessel Injury Model to Study Remodeling." Cell Transplantation 27, no. 9 (2018): 1375–89. http://dx.doi.org/10.1177/0963689718792201.

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Objective: Invasive coronary interventions can fail due to intimal hyperplasia and restenosis. Endothelial cell (EC) seeding to the vessel lumen, accelerating re-endothelialization, or local release of mTOR pathway inhibitors have helped reduce intimal hyperplasia after vessel injury. While animal models are powerful tools, they are complex and expensive, and not always reflective of human physiology. Therefore, we developed an in vitro 3D vascular model validating previous in vivo animal models and utilizing isolated human arteries to study vascular remodeling after injury. Approach: We utili

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Jahan, Reza, Timothy D. Solberg, Daniel Lee, et al. "An Arteriovenous Malformation Model for Stereotactic Radiosurgery Research." Neurosurgery 61, no. 1 (2007): 152–59. http://dx.doi.org/10.1227/01.neu.0000279736.07683.1e.

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Abstract OBJECTIVE To introduce the utilization of a swine arteriovenous malformation (AVM) model for stereotactic radiosurgery research and to describe the morphological changes in the vessels after radiation. METHODS The model was created in six animals by creation of a right-sided carotid-jugular fistula. Pre- and postsurgical hemodynamic evaluation was performed. The left rete was radiated in four animals; two animals were not radiated. All animals were sacrificed 4 months after surgery, and the bilateral retia were obtained at autopsy. RESULTS There were no procedure-related complications

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Roy, Joy, Phan Kiet Tran, Karin Lundmark, Adnan Rahman, and Ulf Hedin. "Control of Smooth Muscle Cell Proliferation – The Role of the Basement Membrane." Thrombosis and Haemostasis 82, S 01 (1999): 23–26. http://dx.doi.org/10.1055/s-0037-1615548.

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SummaryIn atherogenesis and in response to vessel injury, arterial smooth muscle cells (SMCs) are activated from a quiescent, differentiated state into an actively proliferating and synthetic phenotype which migrate into the intima where the cells participate in the formation of a fibrous plaque or intimal hyperplasia. The mechanisms involved in the control of SMC function are not clear and no preventive therapy against SMC activation is available. Interactions between SMCs and the extracellular matrix have been shown to influence SMC structure and function through integrin-mediated signaling

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Koniari, Ioanna, Dimosthenis Mavrilas, Efstratios Apostolakis, et al. "Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aorta’s Stiffness in Hypercholesterolemic Rabbits." Journal of Cardiovascular Pharmacology and Therapeutics 21, no. 4 (2015): 412–22. http://dx.doi.org/10.1177/1074248415617289.

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Aims: This study aims to evaluate atherosclerosis, oxidative stress, and arterial stiffness attenuation by simvastatin and ivabradine in hyperlipidemic rabbits. Methods and Results: Forty rabbits were randomly divided into 4 groups: atherogenic diet (group C), atherogenic diet plus simvastatin (group S), atherogenic diet plus ivabradine (group I), and atherogenic diet plus simvastatin and ivabradine (group S + I). After 9 weeks, rabbits were euthanized and descending aortas excised for mechanical testing. Atherogenic diet induced the development of significant atherosclerotic lesions in group

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Sundt, Thoralf M., and Thoralf M. Sundt. "Principles of preparation of vein bypass grafts to maximize patency." Journal of Neurosurgery 66, no. 2 (1987): 172–80. http://dx.doi.org/10.3171/jns.1987.66.2.0172.

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✓ Experience in cardiovascular and peripheral vascular surgery with saphenous vein bypass conduits is reviewed. It is clear that meticulous technique and graft preparation are crucial to short-term and long-term patency. The risk of early thrombosis is related to damage to the graft 's native intima, graft flow, and coagulability of the patient 's blood. Attention to atraumatic harvesting techniques and perfection of anastomoses are crucial to minimizing intimal damage. Graft inflow and outflow are fundamental principles. The use of vitamin K antagonists and platelet inhibitors may improve gra

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Basi, David L., Neeta Adhikari, Ami Mariash, et al. "Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/− mice." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 1 (2007): H516—H521. http://dx.doi.org/10.1152/ajpheart.00246.2006.

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Redox factor-1 (Ref-1) is a multifunctional protein that regulates redox, DNA repair, and the response to cell stress. We previously demonstrated that Ref-1+/− mice exhibit a significantly reduced Ref-1 mRNA and protein levels within the vasculature, which are associated with increased oxidative stress. The goal of this study was to test the hypothesis that partial loss of Ref-1 altered the cellular response to vascular injury. Fourteen days after femoral artery wire injury, we found that vessel intima-to-media ratio was significantly reduced in Ref-1+/− mice compared with that in wild-type mi

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MAGUIRE, Janet J., Julie C. M. YU, and Anthony P. DAVENPORT. "ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels." Clinical Science 103, s2002 (2002): 184S—188S. http://dx.doi.org/10.1042/cs103s184s.

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We have determined the ability of the endothelin (ET)A receptor antagonist, PD156707 (CI 1020), to inhibit intimal proliferation in human saphenous veins maintained in organ culture. After 28 days in culture, veins exposed to 1µM PD156707 exhibited a significant reduction in intima to intima-plus-media ratio (I:I+M ratio) (0.14±0.02, n = 15) and an increase in lumen area (3.1±0.8mm2) compared with veins cultured without the antagonist (I:I+M, 0.29±0.02; lumen area, 2.5±0.7mm2; n = 23) but were not significantly different from pre-cultured controls (I:I+M, 0.15±0.02; lumen area, 4.4±1.2mm2; n =

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Yang, Genhuan, Rong Zeng, Xitao Song, Changwei Liu, and Leng Ni. "Sophocarpine Alleviates Injury-Induced Intima Hyperplasia of Carotid Arteries by Suppressing Inflammation in a Rat Model." Journal of Clinical Medicine 10, no. 22 (2021): 5449. http://dx.doi.org/10.3390/jcm10225449.

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Introduction: Balloon angioplasty is a commonly applied procedure for treating atherosclerotic vascular diseases. However, the maintenance of long-term lumen patency is relatively difficult due to the occurrence of restenosis. Previous research has shown that the occurrence of vascular wall inflammation is associated with higher rates of restenosis. Sophocarpine (SPC) can exert various therapeutic effects such as anti-oxidation, anti-inflammation, anti-tumor, antivirus and immune regulation. This study aimed to investigate whether SPC can alleviate intimal hyperplasia following balloon injury

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