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Journal articles on the topic 'Intimal layer of large arteries'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Zhang, Hui, Ryu Watanabe, Gerald J. Berry, et al. "Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis." Proceedings of the National Academy of Sciences 114, no. 6 (2017): E970—E979. http://dx.doi.org/10.1073/pnas.1616848114.

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Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4+ T cells and macrophages form organized granulomatous lesions in the walls of affected arteries, destroy the tunica media, and induce ischemic organ damage through rapid intimal hyperplasia and luminal occlusion. Pathogenic mechanisms remain insufficiently understood; specifically, it is unknown whether the unopposed activation of the immune system is because of deficiency of immunoinhibitory checkpoints. Transcriptome analysis of GCA-affe

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2

Planas-Rigol, Ester, Nekane Terrades-Garcia, Marc Corbera-Bellalta, et al. "Endothelin-1 promotes vascular smooth muscle cell migration across the artery wall: a mechanism contributing to vascular remodelling and intimal hyperplasia in giant-cell arteritis." Annals of the Rheumatic Diseases 76, no. 9 (2017): 1624–34. http://dx.doi.org/10.1136/annrheumdis-2016-210792.

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BackgroundGiant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function.ObjectiveTo investigate whether ET-1 induces a migratory myofibroblastic phenotype in human TA-derived vascular smooth muscle cells (VSMC) leading to intimal hyperplasia and vascular occlusion in GCA.Method

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3

Castro Júnior, Cyro, Adamastor Humberto Pereira, and Márcio Bastiani Pasa. "Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs." Acta Cirurgica Brasileira 21, no. 3 (2006): 139–43. http://dx.doi.org/10.1590/s0102-86502006000300004.

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PURPOSE: To compare through digital morphometry, the intimal thickening of the common ilíac arteries (CIA) in pigs, submitted to angioplasty and angioplasty followed by stent implantation. METHODS: Angioplasty was performed in 10 pigs in both CIA, followed by a stent implantation in the left CIA. After four weeks, the aorto-iliac segment was dissected. Histologic slices where divided in three groups: left CIA in the area of the proximal (group 1) and distal (group 2) implantation site of the stent and the region of angioplasty in the right CIA (group 3). The histological slices were digitalize

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Mantskava, Maya, and Nana Momtselidze. "Clinical markers of functional condition of resistive arteries in the young men." Russian journal of biomechanics. 23, no. 4 (2019): 500–504. http://dx.doi.org/10.15593/rjbiomech/2019.4.09.

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Research of resistive vessels, assessment of their functional state is one of the key issues of blood circulation from the point of view of physics, angiology, rheology, blood biomechanics and related sciences. The article examined some physical quantities that describe the functional state of resistive arteries. According to the results of our study, such physical components as the thickness of the intimal medial layer, the coefficient of resistance of the resistive arteries and Young's module turned out to be interesting pathophysiological markers that can reflect the change in the vascular

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Akhtar, R., N. Schwarzer, M. J. Sherratt, et al. "Nanoindentation of histological specimens: Mapping the elastic properties of soft tissues." Journal of Materials Research 24, no. 3 (2009): 638–46. http://dx.doi.org/10.1557/jmr.2009.0130.

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Although alterations in the gross mechanical properties of dynamic and compliant tissues have a major impact on human health and morbidity, there are no well-established techniques to characterize the micromechanical properties of tissues such as blood vessels and lungs. We have used nanoindentation to spatially map the micromechanical properties of 5-μm-thick sections of ferret aorta and vena cava and to relate these mechanical properties to the histological distribution of fluorescent elastic fibers. To decouple the effect of the glass substrate on our analysis of the nanoindentation data, w

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6

Anda, Takeo, Wataru Haraguchi, Hajime Miyazato, et al. "Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma." Journal of Neurosurgery 109, no. 3 (2008): 492–96. http://dx.doi.org/10.3171/jns/2008/109/9/0492.

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The authors describe a very rare case of intravascular large B-cell lymphoma in a woman whose ruptured distal middle cerebral artery (MCA) aneurysms were filled with lymphoma cells. A 69-year-old woman who had undergone artificial graft replacement for an aortic aneurysm presented with transient left hemiparesis. Magnetic resonance imaging demonstrated a small fresh cerebral infarction in the right frontal lobe, although major cervical and cerebral arteries were shown to be intact on MR angiography. Antiplatelet and anticoagulation treatments commenced. On the 21st day after onset, the patient

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Watanabe, Ryu, Toshihisa Maeda, Hui Zhang, et al. "MMP (Matrix Metalloprotease)-9–Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis." Circulation Research 123, no. 6 (2018): 700–715. http://dx.doi.org/10.1161/circresaha.118.313206.

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Rationale: Giant cell arteritis (GCA)—a primary vasculitis of medium and large arteries—is associated with vessel wall damage, elastic membrane fragmentation, and vascular remodeling. Proteinases are believed to contribute to pathogenesis by degrading extracellular matrix and causing tissue injury. Objective: The MMP (matrix metalloproteinase)-9—a type IV collagenase—is produced in the vasculitic lesions of GCA. It is unknown which pathogenic processes are MMP-9 dependent. Methods and Results: The tissue transcriptome of GCA-affected temporal arteries contained high amounts of MMP-9 transcript

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8

Franco, E., D. Iancu, E. Cavallone, et al. "P391 THE DIAGNOSTIC CHALLENGE BETWEEN CHRONIC PULMONARY EMBOLISM AND PULMONARY ARTERY SARCOMA: A CASE REPORT." European Heart Journal Supplements 25, Supplement_D (2023): D198. http://dx.doi.org/10.1093/eurheartjsupp/suad111.462.

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Abstract We report the case of a 63–year–old obese and hypertensive woman, admitted in hospital with worsening dyspnea for 2 weeks and syncope. A suspected chronic thromboembolism was diagnosed nine months before for a similar clinical picture; hematologic screening excluded thrombophilia and NOACs were prescribed. Two–dimensional transthoracic echocardiography showed enlargement of right chambers, the interventricular septum shifted to the left ventricle, showing “D” sign. Color Doppler flow imaging showed moderate regurgitation in tricuspid valve, with indirect pulmonary pressure estimation

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9

Sun, Bing, Anthony P. Davenport, and Morris J. Brown. "Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small intramyocardial compared with large epicardial coronary arteries." Clinical Science 84, no. 1 (1993): 55–60. http://dx.doi.org/10.1042/cs0840055.

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1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries. 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. The density of specific binding sites was higher (maximum binding site density 231 ± 14 fmol/mg of protein) in the small coronary arteries than in the la

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10

Greco, Francesco, Laura Quercioli, Angela Pucci, et al. "Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques." Metabolites 11, no. 4 (2021): 250. http://dx.doi.org/10.3390/metabo11040250.

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Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events. The investigation of atherosclerotic plaques is made difficult by their highly heterogeneous nature. Here we propose a spatially resolved approach based on matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging to investigate lipids in specific regions of atherosclerotic plaques. The method was applied to a small dataset including symptomatic and asymptomatic human carotid atherosclerosis pla

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11

Zeng, Zhongqing, Yongyi Yin, Kung-Ming Jan, and David S. Rumschitzki. "Macromolecular transport in heart valves. II. Theoretical models." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H2671—H2686. http://dx.doi.org/10.1152/ajpheart.00608.2006.

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This paper proposes a new, two-dimensional convection-diffusion model for macromolecular transport in heart valves based on horseradish peroxidase (HRP) experiments on rats presented in the first of the papers in this series (Part I; Zeng Z, Yin Y, Huang AL, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 292: H2664–H2670, 2007). Experiments require two valvular intimae, one underneath each endothelium. Tompkins et al. (Tompkins RG, Schnitzer JJ, Yarmush ML. Circ Res 64: 1213–1223, 1989) found large variations in shape and magnitude in transvalvular 125I-labeled low-density lipoprotein

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Al-Abdula, Maha Abdul-Hadi Abdul-Rida. "Aortic arch in rabbits: Morophological and Histological study." Iraqi Journal of Veterinary Medicine 40, no. 2 (2017): 107–12. http://dx.doi.org/10.30539/iraqijvm.v40i2.121.

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The study aimed to investigate the morphological and histological variations of the aortic arch of local breed rabbits (Oryctylagus conniculus). Nine adult local rabbits were obtained to study the aortic arch (four animals for corrosion cast technique, two injected with colored latex and three for histological study). All the rabbits were euthanized and exsanguinatd, for the cast of the aortic arch they injected by self polymerizing resin via the left ventricle of the heart and the specimens were macerated in (KOH %25) for two weeks and the cast of the aortic arch were prepared. Two main branc

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13

Ferrara, Dardo E., Daiana Weiss, Peter H. Carnell, et al. "Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 1 (2006): R114—R123. http://dx.doi.org/10.1152/ajpregu.00449.2005.

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Traditional imaging with one-photon confocal microscopy and organic fluorophores poses several challenges for the visualization of vascular tissue, including autofluorescence, fluorophore crosstalk, and photobleaching. We studied human coronary arteries (HCAs) and mouse aortas with a modified immunohistochemical (IHC) “en face” method using quantum dot (Qdot) bioconjugates and two-photon excitation laser scanning microscopy (TPELSM). We demonstrated the feasibility of multilabeling intimal structures by exciting multicolored Qdots with only one laser wavelength (750 nm). Detailed cell structur

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14

Viviano, Stephen L., Laurel K. Chandler, and Jonathan D. Keith. "Ultrahigh Frequency Ultrasound Imaging of the Hand: A New Diagnostic Tool for Hand Surgery." HAND 13, no. 6 (2017): 720–25. http://dx.doi.org/10.1177/1558944717731856.

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Background: Ultrasonography is a cost-effective, noninvasive, and expedient imaging modality with numerous clinical applications. Conventional ultrasound uses transducers with frequencies that range from 5 to 12 MHz. However, ultrahigh frequency ultrasound (UHFUS) is capable of producing frequencies up to 70 MHz, which can achieve tissue resolution up to 30 μm. The purpose of our study is to present the capabilities of a novel technology and to describe its possible clinical applications for hand surgery. Methods: The Vevo 2100 (VisualSonics, Toronto, Canada) system was used to perform all ult

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15

Thyberg, Johan, Karin Blomgren, Joy Roy, Phan Kiet Tran, and Ulf Hedin. "Phenotypic Modulation of Smooth Muscle Cells after Arterial Injury Is Associated with Changes in the Distribution of Laminin and Fibronectin." Journal of Histochemistry & Cytochemistry 45, no. 6 (1997): 837–46. http://dx.doi.org/10.1177/002215549704500608.

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Earlier in vitro studies suggest opposing roles of laminin and fibronectin in regulation of differentiated properties of vascular smooth muscle cells. To find out if this may also be the case in vivo, we used immunoelectron microscopy to study the distribution of these proteins during formation of intimal thickening after arterial injury. In parallel, cell structure and content of smooth muscle α-actin was analyzed. The results indicate that the cells in the normal media are in a contractile phenotype with abundant α-actin filaments and an incomplete basement membrane. Within 1 week after endo

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Vilaplana-Carnerero, Carles, Maria Giner-Soriano, Àngela Dominguez, et al. "Atherosclerosis, Cardiovascular Disease, and COVID-19: A Narrative Review." Biomedicines 11, no. 4 (2023): 1206. http://dx.doi.org/10.3390/biomedicines11041206.

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Atherosclerosis is a chronic inflammatory and degenerative process that mainly occurs in large- and medium-sized arteries and is morphologically characterized by asymmetric focal thickenings of the innermost layer of the artery, the intima. This process is the basis of cardiovascular diseases (CVDs), the most common cause of death worldwide. Some studies suggest a bidirectional link between atherosclerosis and the consequent CVD with COVID-19. The aims of this narrative review are (1) to provide an overview of the most recent studies that point out a bidirectional relation between COVID-19 and

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Pasa, Márcio Bastiani, Adamastor Humberto Pereira, and Cyro Castro Júnior. "Morphometric analysis of intimal thickening secondary to stent placement in pig carotid arteries." Acta Cirurgica Brasileira 23, no. 2 (2008): 165–72. http://dx.doi.org/10.1590/s0102-86502008000200009.

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OBJECTIVE: To evaluate intimal thickening secondary to stent placement or to insertion of the delivery system without stent placement in pig carotid arteries. METHODS: Stents were placed in the right common carotid arteries of 7 pigs, and 7 other control pigs underwent only insertion of the delivery system without stent placement. Uninjured contralateral common carotid arteries of the two groups were also used as controls. Samples of arterial tissue, obtained from the area adjacent to the distal segment of the stent four weeks after placement, underwent morphometric analysis. Morphometric data

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18

Nakamura, Takamitsu, Takeo Horikoshi, and Kiyotaka Kugiyama. "Relationship of a thinned medial layer to the attenuated contractile response in atherosclerotic coronary arteries." American Journal of Physiology-Heart and Circulatory Physiology 318, no. 1 (2020): H135—H142. http://dx.doi.org/10.1152/ajpheart.00537.2019.

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Coronary arteries with advanced atherosclerosis do not necessarily have greater contractile responses than those with early atherosclerosis. This study aimed to clarify the relationship between thickness of the medial layer and the contractile response to acetylcholine (ACh) in coronary artery using optical coherence tomography (OCT). The OCT and the vasomotor response to ACh in the left anterior descending coronary artery were assessed in 32 patients with previous myocardial infarction. The intimal and medial layer areas were measured by planimetric analysis of the OCT images. The coronary co

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Megens, Remco T. A., Mirjam G. A. oude Egbrink, Jack P. M. Cleutjens, et al. "Imaging Collagen in Intact Viable Healthy and Atherosclerotic Arteries Using Fluorescently Labeled CNA35 and Two-Photon Laser Scanning Microscopy." Molecular Imaging 6, no. 4 (2007): 7290.2007.00021. http://dx.doi.org/10.2310/7290.2007.00021.

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We evaluated CNA35 as a collagen marker in healthy and atherosclerotic arteries of mice after both ex vivo and in vivo administration and as a molecular imaging agent for the detection of atherosclerosis. CNA35 conjugated with fluorescent Oregon Green 488 (CNA35/OG488) was administered ex vivo to mounted viable muscular (uterine), elastic (carotid), and atherosclerotic (carotid) arteries and fresh arterial rings. Two-photon microscopy was used for imaging. CNA35/OG488 labeling in healthy elastic arteries was compared with collagen type I, III, and IV antibody labeling in histologic sections. F

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Hu, Tingzhang, Song Lin, Ruolin Du, et al. "Design, preparation and performance of a novel drug-eluting stent with multiple layer coatings." Biomaterials Science 5, no. 9 (2017): 1845–57. http://dx.doi.org/10.1039/c7bm00417f.

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21

Biasetti, Jacopo, Pier Giorgio Spazzini, Ulf Hedin, and T. Christian Gasser. "Synergy between shear-induced migration and secondary flows on red blood cells transport in arteries: considerations on oxygen transport." Journal of The Royal Society Interface 11, no. 97 (2014): 20140403. http://dx.doi.org/10.1098/rsif.2014.0403.

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Shear-induced migration of red blood cells (RBCs) is a well-known phenomenon characterizing blood flow in the small vessels (micrometre to millimetre size) of the cardiovascular system. In large vessels, like the abdominal aorta and the carotid artery (millimetre to centimetre size), the extent of this migration and its interaction with secondary flows has not been fully elucidated. RBC migration exerts its influence primarily on platelet concentration, oxygen transport and oxygen availability at the luminal surface, which could influence vessel wall disease processes in and adjacent to the in

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22

Goto, Kenichi, Koji Fujii, and Isao Abe. "Role of Gap-Junctions in Endothelium-Dependent Hyperpolarization in Rat Small and Large Mesenteric Arteries." Hypertension 36, suppl_1 (2000): 700. http://dx.doi.org/10.1161/hyp.36.suppl_1.700.

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P39 In arteries, acetylcholine (ACh) releases endothelium-derived hyperpolarizing factor (EDHF) which is distinct from nitric oxide. The identity of EDHF is still elusive; however several recent studies suggests the possible involvement of myoendothelial gap-junctions in small arteries. To elucidate the involvement of gap-junctions in EDHF responses, we examined the effects of 18α-glycyrrhetinic acid (18α-GA, 10 -4 mol/L), a gap junction inhibitor, on endothelium-dependent hyperpolarization and relaxation to ACh in rat small and large mesenteric arteries. Experiments were perfomed in the prese

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Tuttle, Jay L., Ryan D. Nachreiner, Amardip S. Bhuller, et al. "Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression." American Journal of Physiology-Heart and Circulatory Physiology 281, no. 3 (2001): H1380—H1389. http://dx.doi.org/10.1152/ajpheart.2001.281.3.h1380.

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The magnitude of shear stimulus has been shown to determine the level of growth factor expression in cell culture. However, little is known regarding what effect shear level has on specific arterial wall remodeling events in vivo. We have hypothesized that the rate of luminal diameter change and specific remodeling events within the arterial wall layers are dependent on shear level. Selective ligations were made to alter the number of microvascular perfusion units of mesenteric arteries within the same animal to ∼50%, 200%, and 400% of control. Arterial blood flow and wall shear rate were corr

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Аbdullaiev, R. Ya, I. A. Lurin, О. I. Grechanyk, et al. "Ultrasound diagnosis of firearm damage to major arteries of the neck." EMERGENCY MEDICINE 20, no. 8 (2025): 711–16. https://doi.org/10.22141/2224-0586.20.8.2024.1806.

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Background. The presence of large vessels, many vital structures, and the lack of protection make the neck particularly vulnerable to various injuries, including gunshot wounds. The purpose was to evaluate the possibilities of ultrasonography in the diagnosis of gunshot injuries of the major arteries of the neck. Materials and methods. The analysis of the ultrasonography results in diagnosis of gunshot injuries to the large vessels of the neck in 53 injured persons was carried out. Visualization of the large vessels of the neck was carried out using linear and microconvex sensors in the freque

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McCracken, M. D., and S. Patton. "Pulmonary Arterial Changes in Feline Dirofilariasis." Veterinary Pathology 30, no. 1 (1993): 64–69. http://dx.doi.org/10.1177/030098589303000108.

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Eleven cats with spontaneous dirofilariasis were necropsied; ten were domestic shorthairs and one was a Persian. The cats ranged in age from 1 to 10 years, and 6/11 cats were male. One to three heartworms were present in the right ventricle and pulmonary arteries of each of the 11 cats. Patchy areas of rugose thickening of the intima of the pulmonary trunk and marked villous endarteritis of lobar and medium-sized pulmonary arteries were observed. Affected larger vessels were partially occluded by large villous intimal proliferations that were lined by hyperplastic endothelial cells supported b

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DELAERE, O., U. MENNEN, W. VAN HEERDEN, E. RAUBENHEIMER, A. M. WIESE, and D. BOOMKER. "Side-Effects of Rinsing Fluids on the Rat Femoral Artery." Journal of Hand Surgery 22, no. 5 (1997): 568–73. http://dx.doi.org/10.1016/s0266-7681(97)80346-4.

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Rinsing rat femoral arteries with various fluids in experimental conditions similar to those in clinical practice was found to have deleterious effects on the intimal and medial layers of the vessels. No statistically significant difference was found between the effects of Ringer’s lactate and normal saline. Heparinized saline produced significantly less damage to the medial layer and less platelet cell deposition. Lignocaine 2% was found to be extremely damaging to the whole vessel wall, and highly thrombogenic. Nevertheless, all the arteries in each group remained patent 4 days after rinsing

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Bia, Daniel, Yanina Zócalo, Sandra Wray, and Edmundo I. Cabrera-Fischer. "Comparative in Vivo Analysis of the Role of the Adventitia and the Endothelium on Arterial Mechanical Function: Relevance for Aortic Counterpulsation." International Journal of Artificial Organs 40, no. 6 (2017): 286–93. http://dx.doi.org/10.5301/ijao.5000585.

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Purpose The comparative effect of the intimal and adventitial layers on arterial biomechanics control, in basal and altered conditions, remains to be elucidated. This study aimed ( 1 ) to characterize the arterial conduit (CF) and buffering (distensibility) function of the iliac arteries in in vivo animals, in which the intimal and adventitial layers were removed; ( 2 ) to determine the effects of intra-aortic ballon pumping (IABP) on simultaneously de-adventitialized (DA) and de-endothelialized (DE) iliac arteries before and after induced heart failure. Methods Pressure and diameter signals w

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Arai, Daisuke, Akira Ishii, Hideo Chihara, Hiroyuki Ikeda, and Susumu Miyamoto. "Histological examination of vascular damage caused by stent retriever thrombectomy devices." Journal of NeuroInterventional Surgery 8, no. 10 (2015): 992–95. http://dx.doi.org/10.1136/neurintsurg-2015-011968.

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Background and objectivesAlthough the recently marketed stent retriever thrombectomy devices have demonstrated a high recanalization rate and favorable clinical outcomes, there is a concern about the risks of intimal injuries when pulling out the stent in the unfolded position. In this study, the Solitaire Flow Restoration System and the Trevo retriever were used in a histopathological comparison of vascular injuries caused by stent retriever thrombectomy devices.MethodsRabbit carotid arteries were used in the experiments with stent retriever thrombectomy devices. Carotid artery samples were h

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Rogowska, Anna, Łukasz Obrycki, Zbigniew Kułaga, Claudia Kowalewska, and Mieczysław Litwin. "Remodeling of Retinal Microcirculation Is Associated With Subclinical Arterial Injury in Hypertensive Children." Hypertension 77, no. 4 (2021): 1203–11. http://dx.doi.org/10.1161/hypertensionaha.120.16734.

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The aim of the study was to assess the relationship between hypertensive target organ damage and vessel density (VD), foveal thickness, thickness of retinal nerve fiber layer, ganglion cell complex, and foveal avascular zone (FAZ) using optical coherence tomography angiography in a nonselected group of hypertensive children. One hundred fifty-seven children (56 girls) in mean age 14.9±2.9 years, in whom arterial hypertension was ultimately diagnosed were included in the study. FAZ, whole, fovea, parafovea superficial VD, whole, fovea, parafovea deep VD, foveal thickness, retinal nerve fiber la

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Lewis Clarson, John. "Visualizing arteriosclerosis in dental radiographic shots: case report and literature review." Brazilian Journal of Implantology and Health Sciences 3, no. 1 (2021): 36–48. http://dx.doi.org/10.36557/2674-8169.2021v3n1p36-48.

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Dentists are trained to identify atheromatous plaques of the intimal layer of the common carotid artery on panoramic radiographs, but are less familiar with medial layer arteriosclerosis, which results in “pipe-stem” calcifications that may present on intraoral as well as extraoral dental radiographs. Medial arteriosclerosis is often found in diabetics and patients with chronic kidney disease, and is a strong predictor of stroke and cardiovascular events. Two case reports are presented that illustrate the presentation of medial arteriosclerosis in facial and maxillary arteries on dental radiog

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Titov, Vladimir N., T. A. Rozhkova, and V. A. Amelyushkina. "Atheromatosis of arterial intima." Clinical Medicine (Russian Journal) 94, no. 8 (2016): 582–90. http://dx.doi.org/10.18821/0023-2149-2016-94-8-582-590.

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Phylogenetically late arterial intima of the elastic type contains no proteins for the transfer of ligandless oxidized low density lipoproteins (LDLP) for sedentary macrophages adsorbed on the matrix. Phylogenetically early cells realize the extracellular digestive reaction by releasing proteolytic enzymes (metalloproteinases) into intimal matrix that hydrolize matrix proteoglycans, adsorbed ligandless LDLP, detritus, and complete lysosomal hydrolysis of the most hydrophobic polyenic cholesterol esters (poly-ECS). Smooth muscle cells migrate from the middle muscular layer of the arterial wall,

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JI, Q., Y. Q. MEI, X. S. WANG, and D. W. WUSHA. "WALL SHEAR AND CIRCUMFERENTIAL STRESS CHANGES IN A PORCINE DOUBLE-LAYER VEIN GRAFT." Journal of Mechanics in Medicine and Biology 11, no. 05 (2011): 1059–70. http://dx.doi.org/10.1142/s0219519411004320.

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This study aimed to evaluate short-term changes of wall shear stress and circumferential stress in a self-designed double-layer vein graft in a porcine vein graft model. In this study, left and right hind femoral arteries of 40 white pigs were randomly divided into an experimental group (double-layer vein graft) and a control group (single-layer vein graft). At one hour and then at one, two and four weeks after venous bypass grafting, sets of ten animals underwent Doppler-ultrasonic and electromagnetic flowmeter examinations to calculate wall shear stress in middle sections of the vein grafts.

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Bhardwaj, Rajeev, Ranjana Gupta, Sivaji Patibandla, Himanshu Tanwar, Mehroj Ahmed, and Gaurav Aggrawal. "Takayasu Arteritis Presenting as Severe Pulmonary Hypertension." ASEAN Heart Journal 30, no. 2 (2021): 5–8. http://dx.doi.org/10.31762/ahj2130.0202.

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Takayasu arteritis is an inflammatory disease of large- and medium-sized arteries, with a predilection for the aorta and its branches. Advanced lesions demonstrate a panarteritis with intimal proliferation. It can affect the aorta, subclavian artery, renal artery, iliac artery, coronary artery, and other blood vessels. Pulmonary arteritis is very uncommon in TA. We describe a case of TA, who primarily presented with pulmonary hypertension.

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Zhang, Dechuan, Tieying Yin, Feifei Du, et al. "EVALUATION OF INTIMAL HYPERPLASIA AND THROMBOSIS AFTER IMPLANTATION OF PLATELET GLYCOPROTEIN IIIa MONOCLONAL ANTIBODY-ELUTING STENT IN NEW ZEALAND WHITE RABBIT AORTA OR ILIAC ARTERIES." Biomedical Engineering: Applications, Basis and Communications 27, no. 05 (2015): 1550046. http://dx.doi.org/10.4015/s1016237215500465.

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Since the percutaneous coronary intervention (PCI) was first introduced into China in 1984, this procedure has become widely accepted as an important step in coronary revascularization. This study aims to evaluate intimal hyperplasia and thrombosis after implantation of platelet glycoprotein IIIa monoclonal antibody (mAb)-eluting stent in the New Zealand white rabbit abdominal aorta or iliac artery by comparing CT angiography and pathological experiments. The antibody-eluting stents were prepared by the passive absorption method. Arterial intima in the stented segment and 0.5 cm adjacent to th

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Moore, J. A., and C. R. Ethier. "Oxygen Mass Transfer Calculations in Large Arteries." Journal of Biomechanical Engineering 119, no. 4 (1997): 469–75. http://dx.doi.org/10.1115/1.2798295.

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The purpose of this study was to model the transport of oxygen in large arteries, including the physiologically important effects of oxygen transport by hemoglobin, coupling of transport between oxygen in the blood and in wall tissue, and metabolic consumption of oxygen by the wall. Numerical calculations were carried out in an 89 percent area reduction axisymmetric stenosis model for several wall thicknesses. The effects of different boundary conditions, different schemes for linearizing the oxyhemoglobin saturation curve, and different Schmidt numbers were all examined by comparing results a

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Mendoza, Bernardo, George H. Meier, Kathleen Carter, et al. "Are There Long-Term Consequences of Iliac Artery Trauma during Endograft Implantation? Results of Serial Duplex Ultrasound Follow-up." Journal for Vascular Ultrasound 29, no. 2 (2005): 71–73. http://dx.doi.org/10.1177/154431670502900203.

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Purpose The implantation of abdominal aortic endografts requires the insertion of large devices that have the potential to traumatize the iliac arteries, particularly on the ipsilateral side, where the main body of the endograft is introduced. The consequences of this potential trauma are unknown, but the possibility for significant injury remains. For this reason, a prospective measurement of iliac intimal medial thickness by serial duplex ultrasound was undertaken to determine the effect of endograft placement on iliac arteries. Methods A total of 117 patients had duplex evaluation of their

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Ghaleh, Bijan, Luc Hittinger, Song-Jung Kim, et al. "Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 2 (1998): H539—H551. http://dx.doi.org/10.1152/ajpheart.1998.274.2.h539.

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Coronary vascular responses to acetylcholine (ACh, 3 μg/kg iv), nitroglycerin (NTG, 25 μg/kg iv), and a 20-s coronary artery occlusion (reactive hyperemia, RH) were investigated in seven conscious dogs with severe left ventricular (LV) hypertrophy and chronic coronary pressure overload (CCPO) due to supravalvular aortic banding and in seven control dogs. All dogs were instrumented for measurement of ultrasonic coronary diameter (CD) and Doppler coronary blood flow (CBF). LV-to-body weight ratio was increased by 82% in CCPO dogs. In control dogs, ACh increased CD (+5.9 ± 1.7%). This response wa

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Egorova, N. P., and D. K. Garmaeva. "THE ULTRASONIC EVALUATION OF THE DIAMETER OF COMMON CAROTID ARTERIES AND THE THICKNESS OF THE INTIMA-MEDIA COMPLEX IN EVENKS OF THE ARCTIC ZONE OF THE REPUBLIC SAKHA (YAKUTIA)." Morphological newsletter 27, no. 4 (2019): 21–26. http://dx.doi.org/10.20340/mv-mn.19(27).04.21-26.

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By ultrasonography was study the anatomical structure of the common carotid arteries and the total thickness of their inner and middle membranes (intima-media complex) in Evenks in the Arctic zone of the Republic of Sakha (Yakutia), depending on age and gender. It were studied 210 patients aged 21 to 74 years, the average age was 47 years. The thickness of the intima-media complex was measured on the back (relative to the sensor) vessel wall 1-1,5 cm proximal to the bifurcation. In the presence of thickening of the complex, the measurement was performed in the zone of maximum visual thickening

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Mahaparea, A.P.K., G. Srinivas, D.V. Ramanjaneyulu, et al. "An Essential Parameters of Peripheral Vascular Disease Include Etiology, Risk Factors, Epidemiology and Pathophysiology." Journal of Cardiovascular, Cardiopulmonary Rehabilitation Nursing 3, no. 1 (2025): 16–23. https://doi.org/10.5281/zenodo.14958089.

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<em>A major contributor to morbidity and limb loss in the US is peripheral vascular diseases. Patients with peripheral vascular disease benefit from improved outcomes due to early detection and risk factor modification. This exercise discusses the fundamentals of managing and evaluating peripheral vascular disease, looks at both surgical and non-surgical treatment options, and emphasizes the value of an interprofessional team in assessing this condition. One of the leading causes of morbidity and limb loss in the US is peripheral vascular diseases. Along with peripheral vascular disease, early

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Mahaparea, A.P.K., G. Srinivas, D.V. Ramanjaneyulu, et al. "An Important Parameters of Peripheral Vascular Disease Include Diagnosis, Differential Diagnosis, Treatment, Prognosis and Complications." Journal of Cardiovascular, Cardiopulmonary Rehabilitation Nursing 3, no. 1 (2025): 24–31. https://doi.org/10.5281/zenodo.14958310.

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<em>Peripheral vascular diseases are a significant cause of morbidity </em><em>as well as</em><em> limb loss in the United States. Early identification and risk factor modification are </em><em>responsible </em><em>to </em><em>enhance</em><em> the outcomes in patients </em><em>along </em><em>with peripheral vascular disease. This activity </em><em>explains about</em><em> the principles of evaluation and management of peripheral vascular disease and explores the surgical and non-surgical treatment alternatives, and highlights the importance of the interprofessional team in the evaluation of thi

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Huang, Y., K. M. Jan, D. Rumschitzki, and S. Weinbaum. "Structural Changes in Rat Aortic Intima Due to Transmural Pressure." Journal of Biomechanical Engineering 120, no. 4 (1998): 476–83. http://dx.doi.org/10.1115/1.2798017.

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Huang et al. (1997) propose a new hypothesis and develop a mathematical model to explain rationally the in vitro and in situ measured changes (Tedgui and Lever, 1984; Baldwin and Wilson, 1993) in the hydraulic conductivity of the artery wall of rabbit aorta with transmural pressure. The model leads to the intriguing prediction that this hydraulic conductivity would decrease by one half if the thin intimal layer between the endothelium and the internal elastic lamina volume-compresses approximately fivefold. This paper presents the first measurements of the effect of transmural pressure on inti

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Giesen, Peter, Billie Fyfe, John Fallon, et al. "Intimal Tissue Factor Activity Is Released from the Arterial Wall after Injury." Thrombosis and Haemostasis 83, no. 04 (2000): 622–28. http://dx.doi.org/10.1055/s-0037-1613874.

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SummaryTissue factor (TF), the initiator of coagulation, has been implicated as a critical mediator of arterial thrombosis. Previous studies have demonstrated that TF is rapidly induced in the normal rodent arterial wall by balloon injury, but is not associated with fibrin deposition. A second injury, however, performed 10–14 days after the first, is followed by small platelet-fibrin microthrombi. This study was undertaken to better localize active TF in balloon-injured rat arteries and to explore possible mechanisms underlying the apparent discrepancy between injury-induced TF expression and

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Hua, Le H., Robert L. Dodd, and Neil E. Schwartz. "Concurrent Stenoocclusive Disease of Intracranial and Extracranial Arteries in a Patient with Polycythemia Vera." Case Reports in Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/151767.

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Moyamoya disease is a stenoocclusive disease involving the intracranial carotid and proximal middle cerebral arteries. There are rarely any additional extracranial stenoses occurring concurrently with moyamoya. The pathophysiology of moyamoya remains obscure, but hematologic disorders, notably sickle-cell anemia, have been associated in some cases. We describe the novel case of polycythemia vera associated with severe steno-occlusive disease of both intracranial and extracranial large arteries. A 47-year-old woman with polycythemia vera had multiple transient ischemic attacks, and noninvasive

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Khokhlunov, S. M., D. V. Kuznetsov, A. A. Gevorgyan, et al. "Functional state of coronary shunts from the radial artery in the presence of morphological changes in its wall." Grekov's Bulletin of Surgery 182, no. 2 (2023): 38–45. http://dx.doi.org/10.24884/0042-4625-2023-182-2-38-45.

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The OBJECTIVE of the research was to study the patency of coronary shunts from the radial artery in the presence of morphological changes in its wall in the period from 40 to 52 months after surgery.METHODS AND MATERIALS. Fragments of 110 radial arteries taken from 103 patients for coronary artery bypass grafting in the period from 2018 to 2021 were subjected to histological examination. To assess the functional state of the shunts in the period from 40 to 52 months after surgery, computed tomography of the coronary arteries (CTCA) with contrast was performed in 66 patients.RESULTS. Histologic

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Holzapfel, Gerhard A., Gerhard Sommer, Christian T. Gasser, and Peter Regitnig. "Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 5 (2005): H2048—H2058. http://dx.doi.org/10.1152/ajpheart.00934.2004.

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At autopsy, 13 nonstenotic human left anterior descending coronary arteries [71.5 ± 7.3 (mean ± SD) yr old] were harvested, and related anamnesis was documented. Preconditioned prepared strips ( n = 78) of segments from the midregion of the left anterior descending coronary artery from the individual layers in axial and circumferential directions were subjected to cyclic quasi-static uniaxial tension tests, and ultimate tensile stresses and stretches were documented. The ratio of outer diameter to total wall thickness was 0.189 ± 0.014; ratios of adventitia, media, and intima thickness to tota

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Meziani, Ferhat, Angela Tesse, Sandra Welsch та ін. "Expression and Biological Activity of Parathyroid Hormone-Related Peptide in Pregnant Rat Uterine Artery: Any Role for 8-Iso-Prostaglandin F2α?" Endocrinology 149, № 2 (2007): 626–33. http://dx.doi.org/10.1210/en.2007-0568.

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PTHrP is produced in vessels and acts as a local modulator of tone. We recently reported that PTHrP(1–34) is able to induce vasorelaxation in rat uterine arteries, but in pregnancy, this response is blunted and becomes strictly endothelium dependent. The present study aimed to get insights into the mechanisms involved in these changes because the adaptation of uterine blood flow is essential for fetal development. On d 20 of gestation, RT-PCR analysis of uterine arteries showed that PTH/PTHrP receptor (PTH1R) mRNA expression was decreased, whereas that of PTHrP mRNA was increased. This was ass

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Svyrydova, N. K., O. V. Popov, N. O. Kravchuk, et al. "The condition of the acute cerebral circulation for the ischemic type: the clinical case." East European Journal of Neurology, no. 5(5) (September 20, 2015): 9–12. http://dx.doi.org/10.33444/2411-5797.2015.5(5).9-12.

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Cardiovascular diseases (COD] occupy a leading place in the structure of general morbidity, primary disability and total mortality in Ukraine. Atherosclerosis is a systemic disease of the large and medium-sized arteries causing luminal narrowing (focal or diffuse) as a result of the accumulation of lipid and fibrous material between the intimal and medial layers of the vessel. Atherosclerosis involves an ongoing inflammatory response. Atherosclerosis leads to the formation of atherosclerotic plaques, which gradually increases in size and narrows the lumen of the vessel. Hypertension and athero

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Guo, Xiaomei, Xiao Lu, and Ghassan S. Kassab. "Transmural strain distribution in the blood vessel wall." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 2 (2005): H881—H886. http://dx.doi.org/10.1152/ajpheart.00607.2004.

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The transmural distributions of stress and strain at the in vivo state have important implications for the physiology and pathology of the vessel wall. The uniform transmural strain hypothesis was proposed by Takamyzawa and Hayashi (Takamizawa K and Hayashi K. J Biomech 20: 7–17, 1987; Biorheology 25: 555–565, 1988) as describing the state of arteries in vivo. From this hypothesis, they derived the residual stress and strain at the no-load condition and the opening angle at the zero-stress state. However, the experimental evidence cited by Takamyzawa and Hayashi ( J Biomech 20: 7–17, 1987; and

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Macchioni, Pierluigi, Giuseppe Germanò, Nicolò Girolimetto, et al. "Ultrasound Examination of Common Carotid Adventitial Thickness Can Differentiate Takayasu Arteritis and Large Vessel Giant Cell Arteritis." Journal of Personalized Medicine 14, no. 6 (2024): 627. http://dx.doi.org/10.3390/jpm14060627.

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Pathological studies have demonstrated that the adventitial layer is markedly thickened in Takayasu (TAK) as compared to large vessel giant cell arteritis (LV-GCA). An ultrasound (US) examination of the arterial vessels allows the determination of intima media thickness (IMT) and of adventitial layer thickness (extra media thickness (EMT)). No previous study has evaluated if there are differences in EMT thickness between TAK and LV-GCA. In this cross-sectional retrospective study of stored ultrasound (US) imaging, we have compared common carotid artery (CCA) EMT and IMT in a series of consecut

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Schriefl, Andreas J., Georg Zeindlinger, David M. Pierce, Peter Regitnig, and Gerhard A. Holzapfel. "Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries." Journal of The Royal Society Interface 9, no. 71 (2011): 1275–86. http://dx.doi.org/10.1098/rsif.2011.0727.

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The established method of polarized microscopy in combination with a universal stage is used to determine the layer-specific distributed collagen fibre orientations in 11 human non-atherosclerotic thoracic and abdominal aortas and common iliac arteries (63 ± 15.3 years, mean ± s.d.). A dispersion model is used to quantify over 37 000 recorded fibre angles from tissue samples. The study resulted in distinct fibre families, fibre directions, dispersion and thickness data for each layer and all vessels investigated. Two fibre families were present for the intima, media and adventitia in the aorta

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