Academic literature on the topic 'Intra-islet duct'

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Journal articles on the topic "Intra-islet duct"

1

Okano, Satoshi, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, and Osamu Nakajima. "Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice." Journal of Diabetes Research 2019 (April 24, 2019): 1–11. http://dx.doi.org/10.1155/2019/7234549.

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Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by senescence-associated secretory phenotype- (SASP-) like characters of islets. Earlier studies also showed that atypical duct-like structures in the pancreas developed age-dependently in Tg mice. Numerous reports have described that karyopherin alpha 2 (KPNA2) is highly expressed in cancers of different kinds. However, details of the expression of KPN
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2

Cardinale, Vincenzo, Savino Paradiso, and Domenico Alvaro. "Biliary stem cells in health and cholangiopathies and cholangiocarcinoma." Current Opinion in Gastroenterology 40, no. 2 (2024): 92–98. http://dx.doi.org/10.1097/mog.0000000000001005.

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Purpose of review This review discusses evidence regarding progenitor populations of the biliary tree in the tissue regeneration and homeostasis, and the pathobiology of cholangiopathies and malignancies. Recent findings In embryogenesis biliary multipotent progenitor subpopulation contributes cells not only to the pancreas and gall bladder but also to the liver. Cells equipped with a constellation of markers suggestive of the primitive endodermal phenotype exist in the peribiliary glands, the bile duct glands, of the intra- and extrahepatic bile ducts. These cells are able to be isolated and
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3

Paris, Maryline, Cécile Tourrel-Cuzin, Cédric Plachot та Alain Ktorza. "Review: Pancreaticβ-Cell Neogenesis Revisited". Experimental Diabesity Research 5, № 2 (2004): 111–21. http://dx.doi.org/10.1080/15438600490455079.

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β-cell neogenesis triggers the generation of newβ-cells from precursor cells. Neogenesis from duct epithelium is the most currently described and the best documented process of differentiation of precursor cells intoβ-cells. It is contributes not only toβ-cell mass expansion during fetal and nonatal life but it is also involved in the maintenance of theβ-cell mass in adults. It is also required for the increase inβ-cell mass in situations of increase insulin demand (obesity, pregnancy). A large number of factors controlling the differentiation ofβ-cells has been identified. They are classified
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4

Krakowski, ML, MR Kritzik, EM Jones, et al. "Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes." Journal of Endocrinology 162, no. 2 (1999): 167–75. http://dx.doi.org/10.1677/joe.0.1620167.

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The upregulation of a limited number of growth factors in our interferon-gamma transgenic model for regeneration within the pancreas lead us to propose that these factors are important during pancreatic regeneration. In this study, we have assessed the influence of two growth factors within the pancreas, epidermal growth factor (EGF) and keratinocyte growth factor (KGF), by ectopically expressing these proteins under the control of the human insulin promoter in transgenic mice. This beta-cell-targeted expression of either EGF or KGF resulted in significant morphological changes, including cell
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5

Gross, R., and P. Mialhe. "Free fatty acids and pancreatic function in the duck." Acta Endocrinologica 112, no. 1 (1986): 100–104. http://dx.doi.org/10.1530/acta.0.1120100.

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Abstract. The isolated perfused duck pancreas was used to study the effect of free fatty acids (FFA) on pancreatic function in vitro and to determine whether the FFA-glucagon negative feedback mechanism resulted from a direct inhibitory effect of FFA on the pancreatic A cell. Oleate, 2 mmol/l, increased the output rates of pancreatic somatostatin, glucagon and insulin. As there is poor morphological evidence in the duck for somatostatin to act as a paracrine intra-islet modulator, we reproduced in the pancreatico-duodenal artery, the rise in somatostatin level obtained in the pancreatic efflue
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6

Jiang, Z., and B. A. Woda. "Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat." Journal of Immunology 146, no. 9 (1991): 2990–94. http://dx.doi.org/10.4049/jimmunol.146.9.2990.

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Abstract The Biobreeding Worcester rat provides one of the best models of autoimmune diabetes. Immunopathologic studies of acute diabetes show that the islets are infiltrated by T cells and macrophages. It has been hypothesized that the islets are damaged by the secretion of cytokines such as IL-1 and TNF-alpha and that their function may be altered by IL-6. In this study, we utilized in situ hybridization to determine the expression of the IL-1, TNF, and IL-6 genes within the pancreas of the acute diabetic Biobreeding Worcester rat. These studies showed that cells expressing IL-1, TNF, and IL
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7

Yu-Wen, Tien, Chien Hung-Jen, Chiang Tsai-Chen, et al. "Local islet remodeling associated with duct lesion-islet complex in adult human pancreas." November 7, 2020. https://doi.org/10.5281/zenodo.4256579.

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<strong>Supplementary figure legends</strong> <strong>Supplementary Fig. 1 </strong>(Related to Fig. 1)<strong>. </strong>Gallery of pancreatic tissue maps showing peri-lobular islet aggregation and duct lesion (PanIN) -islet complex in human donor pancreases. Magenta: glucagon. Green: CK7. White: nuclei. Tile scanning and overlay of fluorescence and transmitted light signals are used to detect and identify the lesion-islet complex. <strong>Supplementary Fig. 2 </strong>(Related to Fig. 2)<strong>. </strong>Intra-islet ducts in human pancreas. This unique structure is identified in the PanIN-i
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8

Mei-Hsin, Chung, Chien Hung-Jen, Peng Shih-Jung, et al. "Multimodal 3-D/2-D human islet and duct imaging in exocrine and endocrine lesion environment: associated pancreas tissue remodeling." April 17, 2022. https://doi.org/10.5281/zenodo.6874103.

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<strong>Supplemental Materials</strong> <strong>Supplemental Figures</strong> <strong>Suppl. Fig. S1 </strong>(related to Fig. 1)<strong>. Multimodal imaging of islet aggregation with duct-islet cell cluster in PDAC surgical margin. </strong><strong>(A-I) </strong>and<strong> (J-R) </strong>are<strong> </strong>two examples of the coexistence of islet aggregation, PanIN, acinar atrophy, and fibrosis in the surgical margin distal to PDAC (case No. 1628870 and 4442070). In <em>G</em>, <em>H</em>, <em>P</em>, <em>Q</em>, varying amounts of mucin were observed in the duct lesions. In <em>I</em> an
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9

OKANO, SATOSHI, AKIRA YASUI, SHINICHIRO KANNO, et al. "2090-LB: Characters of Intra-islet Ductal Cells Related to Alpha-Cell Regeneration in Zinc-Binding Site–Mutated CRY1-Expressing Diabetic Mice." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-2090-lb.

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Introduction &amp; Objective: We previously suggested that the regions of intra-islet ductal cells (IIDCs) play roles as the source for endocrine cells, particularly for α-cells, in C414A-CRY1 transgenic mice (TG) (ADA 2023), the characters of IIDCs relevant to the α-cell neogenesis are yet unknown. To clarify the points, we conducted experiments in terms of reactivity to DBA-lectin as well as of the expression of TFF2. Methods: The cells constituting developed IIDC (of duct periphery longer than 500 µm) in TG were classified as strongly or weakly positive both for anti-TFF2 antibodies and for
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10

Bisambar, Chad, Andrew Collier, Fraser Duthie, and Carron Meney. "Non-functional duodenal neuroendocrine carcinoma: a rare cause of diabetes mellitus." Endocrinology, Diabetes & Metabolism Case Reports 2018 (August 23, 2018). http://dx.doi.org/10.1530/edm-18-0061.

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Summary A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary t
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