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1

Yu, A.-Yong, Hua Guo, Qin-Mei Wang, Fang-Jun Bao, and Jing-Hai Huang. "Pupil Dilation with Intracameral Epinephrine Hydrochloride during Phacoemulsification and Intraocular Lens Implantation." Journal of Ophthalmology 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/4917659.

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Objective. To investigate mydriatic effect of intracamerally injected epinephrine hydrochloride during phacoemulsification and intraocular lens (IOL) implantation.Methods. Eighteen cataract patients for bilateral phacoemulsification were enrolled. To dilate pupil, one eye was randomly selected to receive intracamerally 1 mL epinephrine hydrochloride 0.001% for 1 minute after corneal incision (intracameral group), and the contralateral eye received 3 drops of compound tropicamide 0.5% and phenylephrine 0.5% at 5-minute intervals 30 minutes before surgery (topical group). Pupil diameters were measured before corneal incision, before ophthalmic viscoelastic device (OVD) injection, after OVD injection, before IOL implantation, and at the end of surgery.Results. At each time point, the mean pupil diameter in the intracameral group was2.20±0.08,5.09±0.20,6.76±0.19,6.48±0.18, and5.97±0.24 mm, respectively, and in the topical group it was7.98±0.15,7.98±0.15,8.53±0.14,8.27±0.16, and7.93±0.20 mm, respectively. The topical group consistently had larger mydriatic effects than the intracameral group (P<0.05). The onset of mydriatic effect was rapid in the intracameral group. There was no difference in surgical performance or other parameters between groups.Conclusions. Intracameral epinephrine hydrochloride appears to be an alternative to the mydriatic modalities for phacoemulsification and IOL implantation. In comparison with topical mydriatics, intracameral epinephrine hydrochloride offers easier preoperative preparation, more rapid pupil dilation, and comparable surgical performance.
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2

Karp, Carol L., Terry A. Cox, Michael D. Wagoner, Reginald G. Ariyasu, and Deborah S. Jacobs. "Intracameral anesthesia." Ophthalmology 108, no. 9 (September 2001): 1704–10. http://dx.doi.org/10.1016/s0161-6420(01)00793-x.

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3

Anderson, Nicole J. "Intracameral Anesthesia." Archives of Ophthalmology 117, no. 2 (February 1, 1999): 225. http://dx.doi.org/10.1001/archopht.117.2.225.

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4

Keating, Gillian M. "Intracameral Cefuroxime." Drugs 73, no. 2 (January 22, 2013): 179–86. http://dx.doi.org/10.1007/s40265-013-0011-9.

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5

Rush, Sloan W., Duy Vu, and Ryan B. Rush. "The Safety and Efficacy of Routine Administration of Intracameral Vancomycin during Cataract Surgery." Journal of Ophthalmology 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/813697.

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Purpose. To evaluate the safety and efficacy of intracameral vancomycin during cataract surgery using a standardized dosage and delivery technique.Methods. The charts of 20,719 consecutive eyes that underwent phacoemulsification with intraocular lens implantation in a single ambulatory surgery center were retrospectively reviewed over a 5-year period.Results. The first 11,333 consecutive cases did not receive intracameral vancomycin, whereas the next 9,386 consecutive cases all received intracameral vancomycin. There were no significant differences in the baseline characteristics between the cohort of subjects who received intracameral vancomycin and the cohort of subjects that did not. There were a total of 11 subjects (0.97 cases per 1,000) that developed postoperative endophthalmitis in the group that did not receive intracameral vancomycin, whereas there were no cases of postoperative endophthalmitis in the group that received intracameral vancomycin (p= 0.0015). The overall rate of intraoperative and postoperative complications and the final postoperative visual acuities were similar among cohorts. There were no cases of toxic anterior segment syndrome occurring in either group during the study period.Conclusions. Routine administration of intracameral vancomycin during cataract surgery significantly decreased the incidence of postoperative endophthalmitis and was not associated with an increased incidence of postoperative adverse events.
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6

Bowen, Randy C., Andrew Xingyu Zhou, Sailaja Bondalapati, Thomas W. Lawyer, Karisa B. Snow, Patrick R. Evans, Tyler Bardsley, et al. "Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis." British Journal of Ophthalmology 102, no. 9 (January 11, 2018): 1268–76. http://dx.doi.org/10.1136/bjophthalmol-2017-311051.

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BackgroundCurrent practice methods are unclear as to the most safe and effective prophylactic pharmacotherapy and method of delivery to reduce postoperative endophthalmitis occurrence.MethodsA systematic review and meta-analysis using Meta-analysis of Observational Studies in Epidemiology guidelines was performed to compare the efficacy of intracameral cefuroxime, moxifloxacin and vancomycin in preventing postphacoemulsification cataract surgery endophthalmitis. A safety analysis of intracameral antibiotics was concurrently performed.Data sourcesBIOSIS Previews, CINAHL, ClinicalTrials.gov, Cochrane Library, Dissertations & Theses, EMBASE, PubMed, ScienceDirect and Scopus were searched from inception to January 2017. Data were pooled using a random effects model. All articles were individually reviewed and data were extracted by two independent reviewers. Funnel plot, risk of bias and quality of evidence analyses were performed.ResultsSeventeen studies with over 900 000 eyes were included, which favoured the use of intracameral antibiotics at the end of cataract surgery (OR 0.20; 95% CI 0.13 to 0.32; P<0.00001). The average weighted postoperative endophthalmitis incidence rates with intracameral cefuroxime, moxifloxacin and vancomycin were 0.0332%, 0.0153% and 0.0106%, respectively. Secondary analyses showed no difference in efficacy between intracameral plus topical antibiotics versus intracameral alone (P>0.3). Most studies had low to moderate risk of bias. The safety analysis showed minimal toxicity for moxifloxacin. Dosing errors led to the majority of toxicities with cefuroxime. Although rare, vancomycin was associated with toxic retinal events.ConclusionIntracameral cefuroxime and moxifloxacin reduced endophthalmitis rates compared with controls with minimal or no toxicity events at standard doses. Additionally, intracameral antibiotics alone may be as effective as intracameral plus topical antibiotics.
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7

Galvis, Virgilio, Alejandro Tello, Mary Alejandra Sánchez, and Paul Anthony Camacho. "Cohort Study of Intracameral Moxifloxacin in Postoperative Endophthalmitis Prophylaxis." Ophthalmology and Eye Diseases 6 (January 2014): OED.S13102. http://dx.doi.org/10.4137/oed.s13102.

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We conducted a cohort study to evaluate post-cataract surgery endophthalmitis rates in relation to prophylactic intracameral moxifloxacin administration. A total of 2332 patients (2674 eyes) who underwent phacoemulsification by a single surgeon from January 2007 through December 2012 were included in the study. A total of 1056 eyes did not receive intracameral prophylactic moxifloxacin and the antibiotic was injected in 1618 eyes. The incidence of presumed postoperative endophthalmitis in the 2 groups was calculated. The rate of presumed infectious endophthalmitis after cataract surgery between January 2007 and June 2009 (without intracameral moxifloxacin) was 0.094%. The rate in the second period, from July 2009 to December 2012 (with prophylactic intracameral moxifloxacin), was 0%. In our patients, a decline in the incidence of presumed infectious postoperative endophthalmitis appeared to be associated with the application of intracameral moxifloxacin.
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8

Amireskandari, Annahita, Andrew Bean, and Thomas Mauger. "Toxic Anterior Segment Syndrome with Intracameral Moxifloxacin: Case Report and Review of the Literature." Case Reports in Ophthalmological Medicine 2021 (March 2, 2021): 1–6. http://dx.doi.org/10.1155/2021/5526097.

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A case of severe anterior segment toxicity secondary to high-volume, undiluted intracameral moxifloxacin for endophthalmitis prophylaxis is reported. We examine the other reported cases of toxicity after intracameral moxifloxacin, as well as iris depigmentation and transillumination syndromes after oral and topical fluoroquinolone exposure. Additionally, we review the literature on safety, efficacy, and appropriate dosing of intracameral antibiotics with a focus on moxifloxacin.
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Shen, Ying-Cheng, Mei-Yen Wang, Chun-Yuan Wang, Tsun-Chung Tsai, Hin-Yeung Tsai, Hsin-Nung Lee, and Li-Chen Wei. "Pharmacokinetics of Intracameral Voriconazole Injection." Antimicrobial Agents and Chemotherapy 53, no. 5 (March 2, 2009): 2156–57. http://dx.doi.org/10.1128/aac.01125-08.

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ABSTRACT Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-μg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.
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Montan, Per G., Gisela Wejde, Gabor Koranyi, and Margareta Rylander. "Prophylactic intracameral cefuroxime." Journal of Cataract & Refractive Surgery 28, no. 6 (June 2002): 977–81. http://dx.doi.org/10.1016/s0886-3350(01)01269-x.

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Montan, Per G., Gisela Wejde, Hans Setterquist, Margareta Rylander, and Charlotta Zetterström. "Prophylactic intracameral cefuroxime." Journal of Cataract & Refractive Surgery 28, no. 6 (June 2002): 982–87. http://dx.doi.org/10.1016/s0886-3350(01)01270-6.

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12

Fry, Luther L. "Intracameral Preserved Lidocaine." Journal of Cataract & Refractive Surgery 23, no. 1 (January 1997): 10. http://dx.doi.org/10.1016/s0886-3350(97)80141-1.

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13

Kaushik, Sushmita, Jagat Ram, Gagandeep Singh Brar, Arun Kumar Jain, Arunaloke Chakraborti, and Amod Gupta. "Intracameral Amphotericin B." Cornea 20, no. 7 (October 2001): 715–19. http://dx.doi.org/10.1097/00003226-200110000-00009.

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14

Maloof, Anthony, and Valarie Saw. "Prophylactic intracameral vancomycin." Journal of Cataract & Refractive Surgery 30, no. 8 (August 2004): 1610–11. http://dx.doi.org/10.1016/j.jcrs.2004.06.018.

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15

Bäckström, Gunnie, Björn Lundberg, and Anders Behndig. "Intracameral acetylcholine effectively contracts pupils after dilatation with intracameral mydriatics." Acta Ophthalmologica 91, no. 2 (March 16, 2012): 123–26. http://dx.doi.org/10.1111/j.1755-3768.2011.02376.x.

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Kim, Yu Jeong, Su Jin Park, Jong Yeon Lee, Dae Yeong Lee, and Dong Heun Nam. "Intraoperative Complications of Cataract Surgery Using Intracameral Illumination in the Elderly over 75 Years." Journal of Ophthalmology 2019 (January 10, 2019): 1–5. http://dx.doi.org/10.1155/2019/1594152.

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Purpose. To evaluate intraoperative complications and utilization of adjunctive devices between microscope and intracameral illuminations during cataract surgery in the elderly over 75 years. Design. A retrospective, consecutive, interventional case series Participants. Two hundred eighty-six eyes of 184 patients older than 75 years who underwent cataract surgery using microscope and intracameral illuminations. Methods. A chart review was performed on an advanced cataract surgery group of 141 consecutive cases in which the intracameral illumination was used and on a standard cataract surgery group of 145 consecutive cases in which the intracameral illumination was not used. Main Outcome Measures. Intraoperative complications (posterior capsule rupture, radial tear of the anterior capsule, dropped nucleus, or sulcus-implanted/sclera-fixated IOL) and utilization of adjunctive devices (pupil expansion device or anterior capsule staining). Results. The frequency of use of the pupil expansion device was lower in the advanced cataract surgery group than that in the standard cataract surgery group (0.7% vs 6.9%; p=0.007). Furthermore, the rates of a posterior capsule rupture and at least one intraoperative complication were lower in the advanced cataract surgery group than those in the standard cataract surgery group (0.7% vs 4.8%; p=0.067) (0.7% vs 7.6%; p=0.004). Conclusions. In the current cohort of patients over 75 years, the rate of intraoperative complications was lower when using the intracameral illumination than that when using the conventional method. Cataract surgery using intracameral illumination would be good option for elderly people.
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17

Lenci, Lucas T., Eric K. Chin, Christi Carter, Stephen R. Russell, and David R. P. Almeida. "Ischemic Retinal Vasculitis Associated with Cataract Surgery and Intracameral Vancomycin." Case Reports in Ophthalmological Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/683194.

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Recently, there have been reports suggesting that intracameral vancomycin has been associated with retinal vasculitis; some have described this phenomenon as postoperative hemorrhagic occlusive retinal vasculitis. We present a case of a 65-year-old woman who underwent uncomplicated phacoemulsification and posterior chamber intraocular lens implantation followed by intracameral antibiotic prophylaxis. Unlike prior reports, this report demonstrates a case of mild visual reduction and minimal inflammation with subtle but complete unilateral peripheral retinal ischemia associated with cataract surgery and intracameral vancomycin, suggesting a spectrum of toxicity that may be underrecognized.
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18

Schuster, Bradley L. "Intracameral lidocaine for phacoemulsification." Ophthalmology 108, no. 5 (May 2001): 833–34. http://dx.doi.org/10.1016/s0161-6420(00)00438-3.

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19

Lai, Jimmy S. M., Dennis S. C. Lam, and Ricky W. K. Law. "Combined topical-intracameral anesthesia." Ophthalmology 106, no. 9 (September 1999): 1644. http://dx.doi.org/10.1016/s0161-6420(99)90378-0.

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20

Clayman, Henry M. "Intracameral Failure of Polypropylene." Journal of Cataract & Refractive Surgery 15, no. 5 (September 1989): 598–600. http://dx.doi.org/10.1016/s0886-3350(89)80128-2.

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21

Myers, William G. "Safety of intracameral phenylephrine." Journal of Cataract & Refractive Surgery 42, no. 6 (June 2016): 944–45. http://dx.doi.org/10.1016/j.jcrs.2016.04.012.

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22

Delhiwala, Kushal, Rushik Patel, and Bakulesh Khamar. "Intracameral ‘Poké Ball' sign." Indian Journal of Ophthalmology - Case Reports 1, no. 3 (2021): 449. http://dx.doi.org/10.4103/ijo.ijo_3370_20.

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23

Nuzzi, Raffaele, Valentina Baratozzi, Maria Sole Polito, and Federico Tridico. "Efficacy and Safety of an Intracameral Combination of Two Mydriatics and an Anesthetic for Phacoemulsification in Complicated Patients." Open Ophthalmology Journal 12, no. 1 (December 31, 2018): 322–29. http://dx.doi.org/10.2174/1874364101812010322.

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Background: Advantages of intracameral mydriatics have been demonstrated in healthy patients, but safety and efficacy in complicated subjects remain to be assessed. Objective: The purpose of this study is to evaluate efficacy and safety of an intracameral combination of phenylephrine (0.31%), tropicamide (0.02%) and lidocaine (1%) (Mydrane®, Thea Inc.) in phacoemulsification surgery in subgroups of patients affected by different systemic and ocular diseases. Methods: 125 patients were recruited and compared with a control group of 39 patients. Both groups have been divided according to the presence/absence of ocular or systemic diseases. In course of surgery, grade of mydriasis and ocular analgesia have been evaluated by the surgeon. During follow-up, eventual adverse events have been monitored. Also, comfort reported by patients and surgeon has been investigated. Results: 99.2% of patients receiving the intracameral formulation achieved acceptable mydriasis (> 6 mm), maintained during capsulorhexis, phacoemulsification and IOL insertion without the need of additional mydriatics. No adverse events or sings of unsuccessful surgery were observed among treated patients. Conclusion: An intracameral mydriatic solution can be a safe and comfortable tool for inducing and maintaining intraoperative mydriasis and analgesia, even in complicated patients.
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Khripun, Kirill V., Yulia V. Kobinets, and Elizaveta S. Rozhdestvenskaya. "Initial positive first-hand experience of acute keratoconus treatment using platelet-rich serums." Ophthalmology journal 13, no. 4 (December 15, 2020): 67–72. http://dx.doi.org/10.17816/ov26058.

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Presentation of a clinical case of acute keratoconus treatment by the intracameral platelet-rich plasma administration. Clinical and morphological improvement was registered from the first postoperative day, corneal edema and bullous changes completely resolved during 3 weeks. No side effects were observed. The outcome is confirmed by anterior segment optical coherence tomography data Intracameral platelet-rich autologous plasma administration is a safe and effective method of acute keratoconus treatment.
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Bhatta, Subash, Nayana Pant, and Manish Poudel. "Postoperative endophthalmitis with and without intracameral moxifloxacin prophylaxis in a high volume surgery setting." BMJ Open Ophthalmology 6, no. 1 (June 2021): e000609. http://dx.doi.org/10.1136/bmjophth-2020-000609.

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ObjectiveThis study was conducted to understand the effects of intracameral moxifloxacin in decreasing the incidence of postoperative endophthalmitis after cataract surgery in an eye hospital with a high volume surgical load.Methods and analysisIn this single-centre, retrospective, clinical registry-based study, we compared the rates of postoperative endophthalmitis in 31 340 cataract surgery patients operated during 22 months after June 2018 who received intracameral moxifloxacin to 80 643 patients operated during 41 months before June 2018 who did not receive intracameral moxifloxacin. All patients received subconjunctival gentamycin and dexamethasone. Combined surgical procedures were excluded from the study.ResultsThere was a significant reduction (p<0.001) of postoperative endophthalmitis rates in cataract surgeries from 0.144% (116/80 643) to 0.025% (8/31 340) after initiation of intracameral moxifloxacin. Endophthalmitis rates decreased from 0.120% (12/9942) to 0.009% (1/10 787) in phacoemulsification group and from 0.147% (104/70 701) to 0.034% (7/20 553) in manual small-incision cataract surgeries. Gram-positive organisms including Coagulase-negative staphylococci (37.9%, n=11) and Staphylococcus aureus (S. aureus 34.5%, n=10) were the most common organisms isolated out of 29 culture-positive cases. 24.1% (28/116) endophthalmitis cases in group without moxifloxacin were culture positive compared with 14.3% (1/7) of cases in moxifloxacin group. 72% (n=8) of the Coagulase-negative staphylococci and 80% of S. aureus isolates (n=8) showed in vitro sensitivity to moxifloxacin.ConclusionProphylactic use of intracameral moxifloxacin injection in addition to subconjunctival gentamycin in cataract surgery is associated with a significant decrease in rates of postoperative endophthalmitis when compared with the use of subconjunctival gentamycin alone in high volume settings.
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Jiang, Guojian, and Tingjun Fan. "Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment." Oxidative Medicine and Cellular Longevity 2018 (July 8, 2018): 1–8. http://dx.doi.org/10.1155/2018/4967318.

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The introduction of intracameral anaesthesia by injection of lidocaine has become popular in cataract surgery for its inherent potency, rapid onset, tissue penetration, and efficiency. However, intracameral lidocaine causes corneal thickening, opacification, and corneal endothelial cell loss. Herein, we investigated the effects of lidocaine combined with sodium ferulate, an antioxidant with antiapoptotic and anti-inflammatory properties, on lidocaine-induced damage of corneal endothelia with in vitro experiment of morphological changes and cell viability of cultured human corneal endothelial cells and in vivo investigation of corneal endothelial cell density and central corneal thickness of cat eyes. Our finding indicates that sodium ferulate from 25 to 200 mg/L significantly reduced 2 g/L lidocaine-induced toxicity to human corneal endothelial cells, and 50 mg/L sodium ferulate recovered the damaged human corneal endothelial cells to normal growth status. Furthermore, 100 mg/L sodium ferulate significantly inhibited lidocaine-induced corneal endothelial cell loss and corneal thickening in cat eyes. In conclusion, sodium ferulate protects human corneal endothelial cells from lidocaine-induced cytotoxicity and attenuates corneal endothelial cell loss and central corneal thickening of cat eyes after intracameral injection with lidocaine. It is likely that the antioxidant effect of sodium ferulate reduces the cytotoxic and inflammatory corneal reaction during intracameral anaesthesia.
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Cone, Robert E., Subhasis Chattopadhyay, Roshan Pais, Sourojit Bhowmick, Roshanak Sharafieh, Yen Lemire, and James O'rourke. "The Induction of Circulating, ACAID-Inducing Monocytes Requires CCR2/CCL2-Dependent Migration of Circulating F4/80+ Cells into the Anterior Chamber." Ophthalmology and Eye Diseases 2 (January 2010): OED.S6113. http://dx.doi.org/10.4137/oed.s6113.

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To determine the origin of peripheral blood mononuclear cells (PBMC) that activate regulatory T cells in anterior chamber-associated immune deviation (ACAID), fluorescein-labeled PBMC were intravenously injected into mice before the mice received an intracameral injection of antigen. Six-24 hr after intracameral injection, fluorescein-labeled PBMC increased in the iris. Twenty-four-48 hr labeled cells decreased in the iris and increased in the thymus and spleen. The entry of the labeled PBMC into the anterior chamber and subsequent production of PBMC that transfer ACAID required the expression of CCR2 by the PBMC and the production of the chemokine CCL2 by the recipient of the PBMC. The results suggest that the intracameral injection of antigen induces i) the infiltration of F4/80+ PBMC into the AC, ii) where these PBMC are converted to a regulatory phenotype, and iii) recirculate to activate T cells that suppress cell-mediated immunity.
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Sun, Bin-jia, Rong-mei Peng, Qing Lu, and Jing Hong. "Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes." Journal of Ophthalmology 2019 (May 7, 2019): 1–15. http://dx.doi.org/10.1155/2019/3054758.

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Purpose. To evaluate the safety and pharmacokinetic changes of ganciclovir (GCV) intraocular injection. Methods. GCV (2 mg/0.1 mL) was injected into rabbit eyes. Aqueous GCV concentration was detected by high-performance liquid chromatography. Potential toxicity was assessed by slit-lamp examination, optical coherence tomography, fundus examination, confocal microscopy, and histology. Results. Aqueous GCV concentrations were 24.83 ± 6.41 μg/mL, 0.65 ± 0.52 μg/mL, and undetected on the 1st, 3rd, and 7th day after intravitreal injection. GCV could not be detected on the first day after intracameral injection. No corneal abnormality was found after intravitreal injection, but retinal edema was observed on the first day which receded later. Corneal edema was obvious with endothelial cytoarchitecture damaged after intracameral injection; fluid retention also existed in retina. Conclusions. GCV intravitreal injection offers effective, sustained drug concentration in the anterior chamber, and its damage to retina receded over time. Intracameral injection results in rapid drug elimination and severe damage to endothelium and thus is not recommended.
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Gimbel, Howard V., and Ran Sun. "Prophylactic intracameral vancomycin and CME." Ophthalmology 107, no. 9 (September 2000): 1614–15. http://dx.doi.org/10.1016/s0161-6420(00)00124-x.

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Fenzl, Robert E., and James P. Gills. "Intracameral lidocaine in routine phacoemulsification." Ophthalmology 107, no. 10 (October 2000): 1803–4. http://dx.doi.org/10.1016/s0161-6420(00)00236-0.

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Liebmann, Jeffrey M., Keith Barton, Robert N. Weinreb, David A. Eichenbaum, Preeya K. Gupta, Cathleen M. McCabe, Jeremy D. Wolfe, Iqbal Ahmed, Arsham Sheybani, and E. Randy Craven. "Evolving Guidelines for Intracameral Injection." Journal of Glaucoma 29 (March 2020): S1—S7. http://dx.doi.org/10.1097/ijg.0000000000001451.

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Bala, Chandra. "Intracameral antibiotic: the Vancomycin conundrum." Clinical & Experimental Ophthalmology 44, no. 9 (December 2016): 753–54. http://dx.doi.org/10.1111/ceo.12847.

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Chia, K., and S. Teoh. "Transient amaurosis with intracameral lidocaine." Eye 23, no. 6 (July 11, 2008): 1483. http://dx.doi.org/10.1038/eye.2008.201.

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Haripriya, Aravind, and David F. Chang. "Intracameral antibiotics during cataract surgery." Current Opinion in Ophthalmology 29, no. 1 (January 2018): 33–39. http://dx.doi.org/10.1097/icu.0000000000000445.

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Grisanti, Salvatore, Sabine Biester, Swaantje Peters, Olcay Tatar, Focke Ziemssen, and Karl Ulrich Bartz-Schmidt. "Intracameral Bevacizumab for Iris Rubeosis." American Journal of Ophthalmology 142, no. 1 (July 2006): 158–60. http://dx.doi.org/10.1016/j.ajo.2006.02.045.

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Kodjikian, Laurent, Carole Burillon, and Justus G. Garweg. "Intracameral vancomycin and endophthalmitis prophylaxis." Journal of Cataract & Refractive Surgery 30, no. 10 (October 2004): 2030. http://dx.doi.org/10.1016/j.jcrs.2004.08.016.

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Sangtam, Tiakumzuk, and André Mermoud. "Intracameral triamcinolone acetonide in phacotrabeculectomy." Journal of Cataract & Refractive Surgery 40, no. 4 (April 2014): 691–92. http://dx.doi.org/10.1016/j.jcrs.2014.02.011.

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Lim, Chris H. L., Sarah C. Williams, Steven T. H. Yun, Felicia A. Aulia, Zachary E. McPherson, Dinuksha De Silva, Simon Irvine, and Ian C. Francis. "Persistent concerns regarding intracameral cefuroxime." Journal of Cataract & Refractive Surgery 40, no. 7 (July 2014): 1236–37. http://dx.doi.org/10.1016/j.jcrs.2014.05.015.

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Shams, Fatemeh, Amir A. Jafari, and David Mansfield. "Cardiovascular hazard of intracameral phenylephrine." Journal of Cataract & Refractive Surgery 41, no. 9 (September 2015): 2021–22. http://dx.doi.org/10.1016/j.jcrs.2015.08.002.

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Srinivasan, Sathish. "Intracameral mydriatics during cataract surgery." Journal of Cataract & Refractive Surgery 44, no. 3 (March 2018): 257–58. http://dx.doi.org/10.1016/j.jcrs.2018.03.007.

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Galvis, Virgilio, and Alejandro Tello. "Intracameral antibiotics and endophthalmitis incidence." Journal of Cataract & Refractive Surgery 39, no. 2 (February 2013): 312–13. http://dx.doi.org/10.1016/j.jcrs.2012.12.007.

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42

Mustapha, Mushawiahti, Muhammad Hazzril Hamzah, Soon Ken Chow, Nur Syuhada Zulkifli, Zalikha Abdul Latiff, Diana Melissa Dualim, Su Gaik Cheah, and Mae Lynn Catherine Bastion. "Sub-tenon Anaesthesia versus Intracameral Anaesthesia in Patients Undergoing Cataract Extraction: A Comparative Study of the Level of Pain, Visual Perception and Anxiety." International Journal of Medical Students 2, no. 2 (June 22, 2014): 49–52. http://dx.doi.org/10.5195/ijms.2014.83.

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Background: Phacoemulsification is a modern method of cataract extraction. Sub-tenon anaesthesia used to be the preferred anaesthetic technique for this procedure before intracameral anaesthesia gained its popularity in recent years. Nevertheless, many surgeons still believe that sub-tenon anaesthesia is better than topical anaesthesia. This study aimed to evaluate and compare the experiences of patients who were treated for cataract by phacoemulsification surgery using either sub-tenon or intracameral anaesthesia. Methods: Cross-sectional study conducted at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia. Participants were asked to complete a questionnaire within 1-2 hours following surgery. The questionnaires were designed to gather information on the patient’s level of anxiety, visual perception and amount of pain experienced during cataract surgery. Results: A total of 62 patients were included in the study. Thirty-one patients received anaesthesia by sub-tenon injection, whereas another 31 patients received anaesthesia by intracameral injection. There were no significant differences in the level of pain experienced by the two groups of patients during instillation of anaesthesia and during surgery (p=0.205 and p=0.592, respectively). There were also no significant differences in terms of visual perception and anxiety levels during surgery between the two groups (p=0.178 and p=0.731, respectively). Conclusion: Intracameral anaesthesia obviates the need for an injection during cataract surgery and is as comfortable for patients as sub-tenon anaesthesia in terms of visual perception, level of pain, and anxiety.
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Shakya, Kiran, Sangita Shakya, Ram Prasad Pokhrel, and Om Krishna Malla. "Topical proparacaine vs combined topical-intracameral lidocaine anesthesia in phacoemulsification surgery with preoperative counseling about intraoperative visual fear." Journal of Advanced Academic Research 4, no. 1 (March 31, 2018): 82–88. http://dx.doi.org/10.3126/jaar.v4i1.19521.

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Background Phacoemulsication under topical anesthesia makes a quickest visual recovery and reduces surgical time. Topical anesthesia with supplementary intracameral lidocaine may reduce some pain during iris manipulation or iris diaphragm movement.Objective To study the anesthetic efficacy of topical 0.5% proparacaine hydrochloride versus combined topical - intracameral 1% lidocaine injection during phacoemulsification surgery.Method Total 80 patients divided into A and B, each group having 40 patients was enrolled in this study. Phacoemulsification was performed on group A under topical anesthesia with proparacaine hydrochloride 0.5% and on group B under combined topical - intracameral injection of 0.5cc 1% lidocaine. Preoperatively, all patients received counseling about the potential intraoperative visual fear. Each patient was shown visual analogue scale 10 minutes after completion of surgery and was recorded their pain score. Unco-operative patients and previous history of ocular trauma were excluded.Results According to visual analogue scale, on group A, 30% felt no pain, 50% felt mild pain and 20% felt tolerable moderate pain (level 4) and on group B, 80% felt no pain and 20% felt mild pain. The group A perceived pain higher than group B (P <0.001). Mean operation time was 10 minutes. Most of the patients in A and B groups had no eye movement (Group A: 88% and Group B: 95%).Conclusions The combined topical proparacaine - intracameral injection of lidocaine anesthesia is better than topical proparacaine during phacoemulsification ensuring patients and surgeons comfort. Preoperative counseling helps the patients to focus on operating microscope light during surgery.
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Schell, Jonathan C., Steven B. Koenig, Kenneth Bastin, and William J. Wirostko. "Intracameral bevacizumab administered for non-small cell lung cancer metastasis to iris." Clinics and Practice 1, no. 2 (May 30, 2011): 39. http://dx.doi.org/10.4081/cp.2011.e39.

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Ocular iris metastasis from lung cancer is uncommon. We report a patient with metastatic non-small cell lung cancer who was found to have a metastatic lesion to the iris. Local therapy for pain control and vision loss was administered with intracameral bevacizumab. Complete resolution of pain, improvement in vision, and near complete resolution of iris tumor were seen within two months. No ocular toxicity to anterior segment structures was detectable on corneal pachymetry and corneal specular microscopy. This is the first case report demonstrating safety and efficacy of intracameral bevacizumab for iris metastasis from non-small cell lung cancer.
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Chowdhury, Tuhin, and Aditya Pradhan. "Acute Hydrops with Micro-Cornea – an Extremely Rare Condition: A Case Report." Ophthalmology @ Point of Care 1, no. 1 (January 2017): oapoc.0000003. http://dx.doi.org/10.5301/oapoc.0000003.

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Purpose To report the first case of a one-eyed child with micro-cornea, coloboma of iris and acute hydrops without any other disorder of the cornea or systemic disease. Methods Intracameral injection of perfluoro propane (C3F8) gas was performed under general anaesthesia. Results Resolution of the hydrops was observed at 1st week of follow-up, which was confirmed by anterior segment optical coherence tomography. Patient was subsequently lost to follow-up. Conclusions Intracameral injection of perfluoro propane gas is an effective way to quickly resolve acute hydrops. In this specific case, the patient presented with micro-cornea and no other corneal abnormalities.
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Gungor, SirelGur, Begum Bulam, Ahmet Akman, and Meric Colak. "Comparison of intracameral dexamethasone and intracameral triamcinolone acetonide injection at the end of phacoemulsification surgery." Indian Journal of Ophthalmology 62, no. 8 (2014): 861. http://dx.doi.org/10.4103/0301-4738.141045.

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Ozge, Gokhan, Onder Ayyildiz, Murat Kucukevcilioglu, and Tarkan Mumcuoglu. "Comparison of intracameral dexamethasone and intracameral triamcinolone acetonide injection at the end of phacoemulsification surgery." Indian Journal of Ophthalmology 63, no. 3 (2015): 287. http://dx.doi.org/10.4103/0301-4738.156945.

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Rabina, Gilad, Dana Barequet, Michael Mimouni, Shimon Kurtz, Gabi Shemesh, Amir Rosenblatt, and Eldar Rosenfeld. "Intracameral bevacizumab role in trabeculectomy: A 1-year prospective randomized controlled study." European Journal of Ophthalmology 30, no. 6 (September 9, 2019): 1356–61. http://dx.doi.org/10.1177/1120672119874682.

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Purpose: To evaluate the effect of intracameral Bevacizumab on trabeculectomy success rates. Methods: A prospective, randomized, interventional clinical trial. Patients with primary open-angle glaucoma were randomly assigned to two groups: trabeculectomy with mitomycin C and trabeculectomy with mitomycin C and intracameral bevacizumab. Complete success is defined as an intraocular pressure (IOP) reduction of at least 30% from baseline IOP to a measured pressure of between 5 and 18 mm Hg without the use of IOP lowering medications. Qualified success is defined as same achievement of reduced IOP, but with the use of IOP lowering medications. Overall success is defined as same achievement of reduced IOP with or without the use of IOP lowering medications. Results: Thirty-three patients in the mitomycin C group and 36 patients in the mitomycin C and bevacizumab group were included in final analyses. The IOP at presentation was 28.3 ± 8 and 28.4 ± 8.6 mm Hg, compared to 10.8 ± 3.4 and 12.3 ± 3.7 mm Hg at 12 months (p < 0.0001) for the mitomycin C group and the mitomycin C and bevacizumab group, respectively. Complete success at 12 months was achieved in 65% of the mitomycin C group compared to 60% of the mitomycin C and bevacizumab group (p = 0.77). Overall success was achieved in 82% compared to 80% of patients at 12 months (p = 0.78). Both groups showed a statistically significant reduction in IOP after 6 and 12 months (p ⩽ 0.001). There were no statistically significant differences in visual acuity and complications. Conclusion: Intracameral bevacizumab during mitomycin C trabeculectomy in patients with primary open-angle glaucoma apparently does not improve success rates. The adjuvant use of intracameral bevacizumab is therefore not justified.
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Terzariol, Mariana, Paula S. Hünning, Gustavo Brambatti, Luciane de Albuquerque, Carolina Neumann, and João A. T. Pigatto. "Effects of intracameral brilliant blue on the corneal endothelium of swine: in vitro study." Pesquisa Veterinária Brasileira 36, no. 8 (August 2016): 775–80. http://dx.doi.org/10.1590/s0100-736x2016000800016.

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Abstract: The aim was to investigate the ultrastructural changes in the corneal endothelium of pigs induced by intracameral 0.05% brilliant blue. Twenty swine corneas were separated into two groups, the right eye bulbs (control group) and the left eye bulbs (experimental group) of the same animal. All the eye bulbs were evaluated with specular microscopy. The cornea of the right eye bulbs was excised and in the left eye bulbs 0.2ml of 0.05% brilliant blue vital dye (OPTH-blue±) was injected into the anterior chamber, where it remained for one minute. Then the anterior chamber was cleaned with a balanced salt solution injection and the cornea was excised too. All the corneas were evaluated by scanning electron microscopy to evaluate the changes on the endothelium caused by the brilliant blue dye. There were no significant differences between the right corneal endothelium cells and the left corneal endothelium cells with scanning electron microscopy after intracameral use of 0.05% brilliant blue dye. The 0.05% brilliant blue dye concentration did not cause deleterious effects for the swine corneal endothelium after intracameral use and can be a choice for safe staining of the anterior capsule of the lens in cataract surgery.
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Arshinoff, Steve A., and Milad Modabber. "Injection volume and intracameral moxifloxacin dose." Journal of Cataract & Refractive Surgery 46, no. 1 (January 2020): 162–63. http://dx.doi.org/10.1097/j.jcrs.0000000000000007.

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