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Dissertations / Theses on the topic 'Intracellular pathways'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2024

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1

Wilson, Rona Kirstin. "Intracellular pathways in prion peptide trafficking." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433105.

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2

`Arnold, Claire. "Intracellular signalling pathways in myeloproliferative neoplasms." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680884.

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3

Vicario, Chiara. "Magnetogenetic Control of Intracellular Signaling Pathways." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066581/document.

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Le contrôle de l'organisation spatiotemporelle des biomolécules à l'intérieur des cellules vivantes est fondamental pour déchiffrer les mécanismes qui règlent les voies de signalisation cellulaire et leur régulation. Dans ce projet de thèse nous présentons une nouvelle méthode pour induire une perturbation très spécifique et locale des voies de signalisation à l'intérieur des cellules vivantes: la magnétogénétique. Elle est basée sur l'utilisation de nanoparticules magnétiques biofonctionnalisée, pour induire et maintenir des gradients de protéines à l'intérieur des cellules vivantes.Nous avon

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4

Hutchinson, James Lawrence. "Salmonella interactions with host intracellular trafficking pathways." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611631.

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5

Nesbeth, Darren Nicholas. "Biochemical studies of intracellular trafficking pathways in eukaryotes." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313830.

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6

Romero, Alirio Jose Melendez. "Intracellular signalling pathways activated by Fc#gamma#RI." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266462.

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7

Cullen, Peter J. "A study of the regulation of intracellular calcium." Thesis, University of East Anglia, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277302.

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8

Behar, Marcelo S. Dohlman Henrik G. "Dynamic regulation and information transfer in intracellular-signaling pathways." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1546.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Physics and Astronomy." Discipline: Physics and Astronomy; Department/School: Physics and Astronomy.

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9

Pouliot, Philippe. "Implication of intracellular signalling pathways in allergic asthma pathogenesis." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115896.

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The regulation of systemic immune responses is dependent on individual cell responses that will concur to induce a coherent response against a stimulus. In turn, cell response is dependent on the processing of intracellular signals generated at the cell membrane and transmitted through successive protein modifications to the nucleus in order to activate gene transcription. This is referred to as intracellular signalling. Tight control of these mechanisms is required to generate an appropriate cell response to environmental stimulations and globally to establish an appropriate immune response.

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10

Fitzgerald, Jonathan Basil. "Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33869.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.<br>Includes bibliographical references (p. 152-167).<br>Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a transient hydrostatic pressure buildup and fluid exudation from the compacted matrix until relaxation leads to a new equilibrium compressed state. Dynamic co

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11

Sumita, Takuya. "Studies on intracellular protein degradation pathways in plant fungal pathogens." Kyoto University, 2019. http://hdl.handle.net/2433/242706.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21829号<br>農博第2342号<br>新制||農||1068(附属図書館)<br>学位論文||H31||N5201(農学部図書室)<br>京都大学大学院農学研究科地域環境科学専攻<br>(主査)教授田中千尋, 教授本田与一, 准教授刑部正博<br>学位規則第4条第1項該当

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12

BONFILI, LAURA. "Modulation of intracellular proteolytic pathways in neoplastic and neurodegenerative diseases." Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401774.

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The ubiquitinâ€proteasome system (UPS) and autophagy, the two major intracellular protein degradation systems, play a critical role in the regulation and maintenance of cellular homeostasis. The proteasome is known to degrade the majority of intracellular proteins, including cyclins, metabolic enzymes, antigen, transcription factors, and tumour suppressor proteins. Autophagy, or selfâ€eating, is a lysosomal degradation pathway in charge of recycling dysfunctional organelles and aggregated proteins. Impairments in the functionality of proteolytic pathways favour the accumulation of misfolded

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13

Birdsell, Dawn Nice. "REGULATION OF AQUAPORIN-1 ION CHANNEL FUNCTION BY INTRACELLULAR SIGNALING PATHWAYS." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1143%5F1%5Fm.pdf&type=application/pdf.

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14

Roberts, Susan Read. "Mechanotransduction pathways associated with intracellular calcium in chondrocytes within 3D constructs." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270626.

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15

Rapecki, Stephen Edward. "Regulation of leukocyte cytokine production by inhibitors of intracellular signalling pathways." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368573.

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16

Heyward, Catherine Anne. "Investigation of potential phosphatidic acid target proteins in intracellular signalling pathways." Thesis, Birmingham City University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479113.

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17

Liu, Ke, University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Role of second messengers in controlling growth patterns of corneal epithelial cells." THESIS_CSTE_SFH_Liu_K.xml, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh

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18

Rosowski, Emily E. (Emily Elizabeth). "Modulation of innate immune signaling pathways by the intracellular pathogen Toxoplasma gondii." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83639.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Toxoplasma gondii, an obligate intracellular protozoan parasite, is one of the most successful eukaryotic pathogens. It can infect virtually any warm-blooded animal, including humans, in whom it can cause serious disease. Its success is likely due to its ability to mo

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19

Koudelka, Juraj. "Determining TrkB intracellular signalling pathways required for specific aspects of gustatory development." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8830.

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Neurotrophins BDNF and NT4 influence the development of the rodent gustatory system. Despite binding to the same receptor, TrkB, they have different roles. BDNF is chemo-attractive for gustatory neurons and regulates gustatory neuron targeting and number during development. NT4 regulates gustatory neuron number earlier in development than BDNF, but it is not chemo-attractive and does not regulate gustatory neuron targeting. To elucidate the mechanisms that regulate these processes we have examined which TrkB intracellular signalling pathways are required for specific aspects of gustatory devel

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20

Vine, Sarah. "Modulation of intracellular signalling pathways in retinal microvascular cells by elevated glucose." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415918.

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21

Cerqueira, Vera. "Role of intracellular signalling pathways in conferring resistance to endocrine therapies in breast cancer." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4511.

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Breast cancer is the most prevalent form of cancer in women and accounts for 519,000 annual deaths (WHO Statistics). It has long been established that oestrogen (E2) stimulates tumour growth of oestrogen receptor (ER) positive breast cancer and is involved in the pathogenesis of the disease. Consequently, therapeutic approaches targeting the ER were developed. The use of endocrine therapy is an integral component in treating breast cancer however resistance to such drugs is a major limitation. Unfortunately, even initially responding tumours eventually develop resistance - acquired resistance.

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22

Pollock, Jamie. "Calcium mobilisation from intracellular stores in cultured DRG neurones : modulation by metabotropic glutamate receptors, TNF and sphingolipids." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325230.

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23

Jones, Sarah Elizabeth. "The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1668/.

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Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of research to augment prostate cancer therapies. In this study, the endogenous anti-inflammatory molecule cAMP was investigated as a mechanism by which to inhibit IL-6-induced STAT3 activation in the DU145, LNCaP and PZ-HPV-7 prostate epithelial cells. Elevation of cAMP attenuated IL-6-mediated activation

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24

Jury, Elizabeth Carole. "Dysregulated intracellular signalling pathways in T lymphocytes from patients with systemic lupus erythematosus." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411032.

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25

FUMAGALLI, SILVIA. "Characterization of the intracellular pathways involved in IL-22 production by dendritic cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29857.

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Dendritic cells (DCs) play a key role in the inflammatory process. They participate to the activation of the immune response by a direct cellular contact through receptor-ligand mediated interactions or by the production of specific cytokines able to modulate different cell type activity. In this study, we show that DCs produce the novel cytokine IL-22 in response to TLRs ligands and we studied IL-22 gene transcript modulation both in vitro (Bone Marrow-derived DCs) and in vivo (CD11c+) derived DCs. Several non hematopoietic cells, in particular epithelial cells, express the IL-22 receptor tha

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26

Raman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.

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27

Didangelos, Athanasios. "Intracellular signalling pathways activated in cartilage by injury and their modulation by synovial fluid." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445330.

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28

Perkins, Jonathan Edward. "A study of EGF-induced intracellular signalling pathways and effects in first trimester trophoblast." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398444.

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29

Rohwer, Forest. "Interleukin-2 activation of intracellular signaling pathways : effects on gene expression, proliferation, and apoptosis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9806513.

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30

Whitfield, Robert. "The role of intracellular signalling pathways in CHO cell growth in a synthetic environment." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6454/.

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Industrial batch and fed-batch culture of Chinese hamster ovary (CHO) cell lines for the production of recombinant proteins, utilises the ability of engineered CHO cells to grow and proliferate in suspension in a synthetic environment that is free of many of the extracellular signals (e.g. exogenous growth factors, cell to matrix and cell to cell contacts) that control growth in vivo. This functional capability derives from extensive cell culture experimentation and lengthy adaptation processes to generate production cell lines. Many different approaches have been used in this study to develop

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31

SALVATORE, DANIELA. "ASSESSMENT OF INTRACELLULAR REDOX-BALANCE ROLE IN TMZ-RESISTANCE-RELATED CYTOPROTECTIVE PATHWAYS IN GBM." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/702299.

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Background: Glioblastoma (GBM) represents the most aggressive astrocytic brain tumour in adults and exhibits a dismal prognosis related to resistance to therapy, which is principally based on Temozolomide plus RT (Stupp protocol). Among crucial factors which are involved in resistance to TMZ treatment, HIF-1α emerges since it activates several pathways, among which angiogenesis and EMT. Beyond its primary alkylating power, TMZ can exerts other secondary effects within cells, as ER stress-mediated ROS release from mitochondria and activation of autophagy. Several works have described HIF-1α deg

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32

Hofer, Matthias Philipp. "Identification and characterisation of regulators of oligodendrocyte precursor cell differentiation and associated intracellular signalling pathways." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648833.

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33

Nguyen, Bao-Anh Vu. "Characterisation and modulation of the intracellular inflammatory signalling pathways activated during surgery with cardiopulmonary bypass." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/33259.

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Surgery with cardiopulmonary bypass (CPB) is associated with post-operative complications due to systemic inflammation. However, the intracellular signalling pathways that promote inflammation in cardiac surgery with CPB are uncertain. The studies presented in this thesis were designed to illuminate these molecular mechanisms, thereby informing the development of novel anti-inflammatory strategies. This was addressed through a clinical trial to determine the effects of CPB on inflammatory signalling in leukocytes (Chapter 4). In this study, the induction of reactive oxygen species (ROS) and th

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34

Thakker, Parva. "T Cell Intrinsic and Extrinsic Role of XIAP, During CD8 T Cell Response Against Intracellular Pathogens." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42419.

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The magnitude and effectiveness of CD8 response against intracellular pathogens is directed by survival and apoptotic signals that govern the fate of T cells. XIAP is a bona fide endogenous inhibitor of apoptotic signals. In this thesis, I have investigated the role of XIAP at various stages of CD8 T cell response. I used both in vivo and in vitro models to show that XIAP acts in a CD8 T cell extrinsic and intrinsic manner to regulate the expansion and contraction phases of the CD8 T cell response, respectively. During the expansion phase, XIAP prevents the cell death of APCs to promote APC-

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35

Marshall, Kirsty Mary. "Investigation of the intracellular pathways required for 5HT-induced mitogenesis and their role in pulmonary hypertension." Connect to e-thesis, 2007. http://theses.gla.ac.uk/103/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references. Print version also available.

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36

Marshall, Kirsty M. "Investigation of the intracellular pathways required for 5HT-induced mitogenesis and their role in pulmonary hypertension." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/103/.

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ABSTRACT Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterised by increased pulmonary vascular resistance and elevated pulmonary artery pressure, leading to right ventricular failure and eventually death. The monoamine 5-hydroxytryptamine (5HT) has been implicated in the processes of pulmonary vasoconstriction and pulmonary artery remodelling that contribute to the development of the PAH. However, the signalling mechanisms utilised by 5HT that contribute to pulmonary vascular remodelling are still unclear and appear to be cell-type specific, with much of the wor

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37

Hutchinson, J. L. "Intracellular targeting mechanisms of Salmonella virulence effector proteins, and bacterial interactions with host antigen presentation pathways." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604849.

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SPI2 effectors are responsible for an observed <i>Salmonella-</i>specified downregulation of MHC Class II at the surface of infected cells. The cooperative contribution of SPI2 effector interactions to the maturation of the <i>Salmonella-</i>containing vacuole (SCV) leads to the hypothesis that correct localisation of effectors following their secretion into the host cell is important to their function. Work described herein characterises the localisation of a key virulence factor, SifA, which contains a cysteine-rich C-terminal motif previously proposed to be a site for host lipid attachment.

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38

Rohl, Joan. "Intracellular trafficking and secretion of matrix metalloproteinases during macrophage migration." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/102374/1/Joan_Rohl_Thesis.pdf.

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This thesis advances the knowledge of intracellular trafficking pathways for the cell surface delivery of Matrix metalloproteinases 9 and 14 in macrophages. As elevated and persistent levels of these proteolytic enzymes contribute to excessive inflammation and poor wound healing outcomes, the findings from this thesis could lead to the development of improved therapeutics for the treatment of chronic wounds. Trafficking machinery proteins responsible for cell surface delivery of Matrix metalloproteinase 14, matrix degradation and macrophage invasion was identified and could be used as novel th

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39

Hurst, Samantha. "n-3 Polyunsaturated fatty acid effects on inflammatory mediator activity and intracellular signalling pathways in chondrocyte metabolism." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55511/.

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Previous studies have shown that supplementation of n-3 polyunsaturated fatty acids (PUFAs) has a beneficial effect on reducing the expression and activity of degradative enzymes and inflammatory factors known to cause damage and destruction of cartilage in arthritic diseases. The aims of this thesis was to use a well-established in vitro model of cartilage degradation to further these studies and to investigate how n-3 PUFAs effect the expression of inflammatory factors at a proteomic level and to use specific inhibitors to identify possible signalling pathways involved in cartilage metabolis

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40

Pirkl, Martin Franz-Xaver [Verfasser], and Rainer [Akademischer Betreuer] Spang. "Indirect inference of synergistic and alternative signalling of intracellular pathways / Martin Franz-Xaver Pirkl. Betreuer: Rainer Spang." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1110148615/34.

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41

Xiong, Qingming. "Anaplasma phagocytophilum and Ehrlichia ewingii Exploit Host Signaling Pathways for Their Infection." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1245167091.

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42

Matos, Pinto Thiago. "Computational models of intracellular signalling and synaptic plasticity induction in the cerebellum." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11560.

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Many molecules and the complex interactions between them underlie plasticity in the cerebellum. However, the exact relationship between cerebellar plasticity and the different signalling cascades remains unclear. Calcium-calmodulin dependent protein kinase II (CaMKII) regulates many forms of synaptic plasticity, but very little is known about its function during plasticity induction in the cerebellum. The aim of this thesis is to contribute to a better understanding of the molecular mechanisms that regulate the induction of synaptic plasticity in cerebellar Purkinje cells (PCs). The focus of t

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43

Biever, Anne. "Regulation of the protein synthesis machinery in the striatum." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT002.

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Le striatum dorsal et le noyau accumbens (NAc) jouent un rôle crucial dans la sélection et l’exécution de mouvements résultant de l’intégration de signaux dopaminergiques et d’informations glutamatergiques sensorielles. A ce jour, les mécanismes moléculaires à travers lesquels la dopamine (DA) régule la plasticité des neurones épineux moyens du striatum (MSNs) sont peu connus. La synthèse des protéines est un événement essentiel requis pour la plasticité synaptique et la mémoire à long terme. Dans de nombreuses régions cérébrales, l’initiation, étant l'étape limitante de la synthèse protéique,

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44

Al-Rasheed, Nawal Mohammed. "Proinsulin C-peptide : activation of intracellular signalling pathways and modulation of transcription factors in opossum kidney proximal tubular cells." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/29949.

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In recent years an increasingly substantial body of data, supports a role for C-peptide in several biological activities. However, the precise molecular mechanisms of C-peptide action are not fully understood. The aim of this thesis was to study the intracellular signalling pathways and the transcription factors that C-peptide activates in proximal tubular cells using opossum kidney cells (OK) as a model. Using specific inhibitors and phospho-specific antibodies, intracellular signalling pathways activated by C-peptide were examined by kinase assay and Western blotting. The results show that C

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45

Watt, Fiona Elizabeth. "Investigation of the effects of injury upon intracellular signalling pathways and expression of inflammatory response genes in articular cartilage." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4701.

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Damage to joints predisposes to osteoarthritis. The mechanism by which injury to cartilage might lead to net matrix loss and cartilage degeneration remains unknown. Following experimental sharp injury to porcine articular cartilage (dissection from, or scoring of the articular surface), our group has previously shown rapid activation of the 3 mitogen activated protein kinase (MAPK) pathways in cartilage. Activation of ERK, and probably also p38 MAPK, is due to release of fibroblast growth factor (FGF) from the matrix after injury. However, despite a long search, the cause of JNK activation fol

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46

Ng, Dominic Chi Hiung. "Characterizing intracellular signaling mechanisms involved in the progression of cardiac hypertrophy and failure : involvement of JAK/STAT and MAPK pathways." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2003. http://theses.library.uwa.edu.au/adt-WU2003.0032.

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[Truncated abstract] The innate ability of the heart to compensate for an increase in workload as a result of disease or injury, through an increase in size and mass is known as cardiac hypertrophy. The hypertrophy of the heart compensates for an increase in workload with an increase in cardiac output. However, excessive hypertrophy can result in cardiac dysfunction and substantially increases the risk of cardiac failure and mortality. The molecular mechanisms that regulate the development of cardiac hypertrophy and cardiac failure are not entirely understood. Traditionally, the G-protein Cou

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47

Velthuis, Jarig Herman Lambertus. "Natural killer cell-induced apoptosis in rat colon carcinoma cells : a study on effector mechanisms and their intracellular signaling pathways /." Leiden : [Universiteit Leiden], 2003. http://catalogue.bnf.fr/ark:/12148/cb399324262.

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48

Tjong, Yung-wui, and 鍾勇會. "Mechanisms of endogenous nitric oxide production and intracellular pathways in rat hippocampal CA1 calcium response to hypoxia and in-vitro ischemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30073005.

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49

Liu, Ke. "Role of second messengers in controlling growth patterns of corneal epithelial cells." Thesis, View thesis, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh

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50

Guo, Daorong. "Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/531.

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During development, axons respond to a variety of guidance cues in the environment to navigate to the proper targets. Sonic hedgehog (Shh), a classical morphogen, has been shown to function as a guidance factor that directly acts on the growth cones of various types of axons. We previously found that Shh affects retinal ganglion cell (RGC) axonal growth and navigation in a concentration-dependent manner. However, the signaling pathways that mediate such events are still unclear. In this thesis, we show that high concentrations of Shh induce growth cone collapse and repulsive turning of the chi

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