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Relevant bibliographies by topics / Intracellular signal transduction / Dissertations / Theses

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Dissertations / Theses on the topic 'Intracellular signal transduction'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

McKay, Jodi Ho-Jung. "HRas intracellular trafficking and signal transduction." [Ames, Iowa : Iowa State University], 2007.

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2

Legewie, Stefan. "Systems biological analyses of intracellular signal transduction." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16018.

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An der Interpretation extrazellulärer Signale beteiligte Regulationsnetzwerke sind von zentraler Bedeutung für alle Organismen. Extrazelluläre Signale werden gewöhnlich durch enzymatische Kaskaden innerhalb weniger Minuten in den Zellkern weitergeleitet, wo sie langsame Änderungen der Genexpression bewirken und so das Schicksal der Zelle beeinflussen. Im ersten Teil der Arbeit wird durch mathematische Modellierung untersucht, wie die MAPK Kaskade Signale von der Zellmembran in den Kern weiterleitet. Es wurden Netzwerkeigenschaften herausgearbeitet, die verhindern, dass die MAPK Kaskade fälschl

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3

Bottomley, Matthew James. "Biophysical studies of intracellular signal transduction proteins : investigating the structure-function relationship." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286570.

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4

Hao, Baixia, and 郝佰侠. "Regulatory and functional studies of store-operated calcium entry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196486.

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Ca2+ signaling is essential for a wide variety of cellular activities, ranging from short term activities, such as synaptic and muscle contraction, to long term processes, such as proliferation and differentiation. Store-operated Ca2+ entry (SOCE), an important Ca2+ influx pathway in non-excitable cells, well coordinates Ca2+ release from ER and Ca2+ influx through plasma membrane. STIM1 and Orai1, serving as ER Ca2+ sensor and pore forming subunit, respectively, are the two essential components of SOCE machinery. In addition to activate Orai1 channel, studies have shown that STIM1 regulates o

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5

Kemp, Daniel M. "Reporter gene analysis of regulatory mechanisms in cAMP signalling." Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310202.

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6

Lau, See-yan. "A study of intracellular signals of K-opioids in non-neuronal cells /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19667139.

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7

Kawano, Yuichi. "Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3593-9/.

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8

劉思恩 and See-yan Lau. "A study of intracellular signals of K-opioids in non-neuronal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214290.

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9

Sadreev, Ildar. "Mathematical modelling of inter- and intracellular signal transduction : the regulatory role of multisite interactions." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/21212.

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Signalling processes regulate various aspects of living cells via modulation of protein activity. The interactions between the signalling proteins can occur at single or multiple sites. Although single site protein interactions are relatively easy to understand, these rarely occur in living systems. It is therefore important to investigate multisite interactions. Despite the recent progress in experimental studies, the underlying molecular mechanisms and molecular functions of the multisite interactions are still not clear and therefore require systems approaches for deeper understanding, for

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10

Li, Sen, and 李森. "Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46940546.

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11

Hassan, Mohamed. "Interference of Hepatitis C virus (HCV) core protein with intracellular signal transduction processes in liver cells /." Aachen : Shaker, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012995533&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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12

Chan, Ming Hang (Stanley), and stanley chan@baker edu au. "Investigation of The Intracellular Signalling Pathway for Interleukin-6 Gene Expression in Skeletal Muscle." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080206.091026.

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13

Hui, Xin [Verfasser], and Peter [Akademischer Betreuer] Lipp. "Protein Kinase C, the Spatial and Temporal Modulator of Intracellular Signal Transduction / Xin Hui. Betreuer: Peter Lipp." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1072409984/34.

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14

Winegar, Bruce D. (Bruce David). "Roles of Calcium Ions and Cyclic AMP in Olfactory Transduction." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331287/.

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The roles of Ca2 + and cAMP in olfactory transduction were explored using agents which affect calcium channels and second messenger systems. These agents were applied at certain calculated final concentrations onto olfactory epithelia of urethane-anesthetized frogs (Sana PiPlens) by two-sec aerosol spray. During extracellular recording, saturated vapors of isoamyl acetate were delivered every 100 sec in 0.3 sec pulses to produce an electroolfactogram (EOG). Inorganic cations that block inward calcium currents inhibit EOG responses with the following rank order: (La3+) > (Zn2+, Cd2+) > (Al3+,

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15

Tong, Chun-kit Benjamin, and 唐俊傑. "Molecular mechanism of disrupted capacitative calcium entry in familial Alzheimer's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205870.

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Presenilin (PS) is the catalytic subunit of the gamma-secretase which is responsible for the cleavage of amyloid precursor protein to form beta amyloid (Aβ). Mutations in PS cause familial Alzheimer’s disease (FAD) by increasing the Aβ plaques formation in the brain and thereby induce neurodegeneration. Apart from this, FAD-linked PS mutations have been demonstrated to disrupt cellular calcium (Ca2+) homeostasis. Ca2+is a vital secondary messenger that involved in various neurophysiological functions, including memory, learning, and neuroplasticity and mounting evidence suggesting that Ca2+dys

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16

Zhong, Zhihui. "Proinsulin c-peptide : membrane interactions and intracellular signaling /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-886-6.

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17

Öberg, Camilla. "The life and death of the notch intracellular domain /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-464-X/.

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18

Al-Khalili, Lubna. "Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-866-1/.

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19

Ng, Dominic Chi Hiung. "Characterizing intracellular signaling mechanisms involved in the progression of cardiac hypertrophy and failure : involvement of JAK/STAT and MAPK pathways." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2003. http://theses.library.uwa.edu.au/adt-WU2003.0032.

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[Truncated abstract] The innate ability of the heart to compensate for an increase in workload as a result of disease or injury, through an increase in size and mass is known as cardiac hypertrophy. The hypertrophy of the heart compensates for an increase in workload with an increase in cardiac output. However, excessive hypertrophy can result in cardiac dysfunction and substantially increases the risk of cardiac failure and mortality. The molecular mechanisms that regulate the development of cardiac hypertrophy and cardiac failure are not entirely understood. Traditionally, the G-protein Cou

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20

Webb, Dominic-Luc. "Temporal monitoring of intracellular Ca²⁺ signaling and origins of Ca²⁺ oscillations /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-741-3/.

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21

Hung, Chun-hin, and 孔進軒. "Effect of novel Chinese specific presenilin-1 V97L mutation on intracellular calcium homeostasis in human neuroblastoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193533.

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Presenilin-1 (PS1) mutations caused by the PSEN1 gene mutations are the major cause of early onset familial Alzheimer’s disease (EOFAD). Two Chinesespecific EOFAD related PS1 mutations, V97L and A136G, have been found. Studies suggested that V97L mutation lead to the overexpression of Aβ42 and tau hyperphosphorylation, which are the major hallmarks of Alzheimer’s disease (AD), while properties of A136G were unclear. Since calcium dysregulation was suggested to play an important role in AD, the research project investigated if V97L and A136G mutations also lead to altered endoplasmic reticulum

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22

Ontiveros, Steven J. "Intracellular trafficking of the hantaviral nucleocapsid protein and its function in modulation of immune signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/ontiveros.pdf.

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23

Kajikawa, Mariko. "An insulinotropic effect of vitamin D analog with increasing intracellular Ca[2+] concentration in pancreatic β-cells through non-genomic signal transduction". Kyoto University, 2001. http://hdl.handle.net/2433/150514.

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24

Kam, Wan-lung Kenneth. "Effect of ovariectomy and estrogen replacement on the [beta]-Adrenergic receptor signaling pathway and intracellular Ca2+ homeostasis in the rat heart." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31473143.

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25

Kinkl, Norbert. "Mechanisms of action of fibroblast growth factor 2 (FGF2) in rat retinal cells : photoreceptor survival and intracellular signaling." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13166.

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La dégénérescence des photorécepteurs est à l'origine de nombreuses pathologies rétiniennes aboutissant à une malvoyance voire à la cécité. Les facteurs neurotrophiques représentent une approche thérapeutique potentielle. Au cours de cette thèse nous nous sommes intéressés aux mécanismes d'actions in vitro d'un facteur neurotrophique exprimé dans la rétine, le FGF2. Afin d'étudier les effets directs du FGF2 sur la survie des photorécepteurs, nous avons mis au point un nouveau modèle de culture pure en photorécepteurs à partir de rétine jeune de rat. La pureté en photorécepteurs des cultures es

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26

Arastoo, Mohammed. "Characterisation of phospholipase C-η enzymes and their relevance to disease". Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/15698.

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Phospholipase C enzymes are a class of enzymes that catalyse the cleavage of the membrane phospholipid, phosphatidylinositol bisphosphate (PtdIns(4,5)P₂) into the second messengers, inositol trisphosphate (Ins(4,5)P₃) and diacylglycerol (DAG). Six classes of PLC enzymes have been identified based on their structure and mechanism of activation. PLCηs are the most recently identified family and consist of two isozymes, PLCη1 and PLCη2. The aim of this thesis is to further understand the mechanisms of PLCη activation, the role of PLCη2 in relation to neuritogenesis and their roles in certain dise

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27

Kral, Rosana Maria. "The versatility of Fas in death and survival signalling : role of a basic motif in the membrane-proximal intracellular region of the receptor." Nice, 2009. http://www.theses.fr/2009NICE4061.

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The receptor Fas/CD95 can trigger cell death if activated by its ligand, FasL. In addition, Fas can mediate proliferation and differentiation. An imbalance between these life-and-death decisions can cause diseases (e. G. Cancer), thus understanding how these different pathways are controlled is important for the development of therapeutic strategies. Our objective is to dissect the initial events of Fas-mediated signalling at the plasma membrane, focussing on the role of specialized nanodomains enriched in sphingolipids and cholesterol (SCNs or lipid rafts). Chakrabandhu et al. (2007) showed t

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Matos, Pinto Thiago. "Computational models of intracellular signalling and synaptic plasticity induction in the cerebellum." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11560.

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Many molecules and the complex interactions between them underlie plasticity in the cerebellum. However, the exact relationship between cerebellar plasticity and the different signalling cascades remains unclear. Calcium-calmodulin dependent protein kinase II (CaMKII) regulates many forms of synaptic plasticity, but very little is known about its function during plasticity induction in the cerebellum. The aim of this thesis is to contribute to a better understanding of the molecular mechanisms that regulate the induction of synaptic plasticity in cerebellar Purkinje cells (PCs). The focus of t

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29

Magno, Aaron. "Proteins associated with the intracellular signalling tail of the calcium-sensing receptor and their impact on receptor function." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0028.

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[Truncated abstract] The calcium-sensing receptor (CaR) is a G protein-coupled receptor that can respond to changes in extracellular calcium and plays an integral role in calcium homeostasis. Later studies revealed that the CaR was stimulated by not just calcium, but a diverse range of stimuli and that activation of the receptor regulated a host of different biological processes. The CaR is linked to these cellular responses via the various signalling pathways initiated by the receptor. Recent yeast two-hybrid studies have identified a number of accessory proteins that, through their interacti

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30

CORRICELLI, Mariangela. "Two different points of view on signal transduction: defective autophagy as a key feature of Cerebral Cavernous Malformations and c-Src as modulator of intracellular Ca2+ homeostasis." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2478764.

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Nel primo progetto abbiamo indagato il coinvolgimento dell’autofagia nella patogenesi delle Malformazioni Cavernose Cerebrali (CCM). CCM è una grave malattia cerebrovascolare che colpisce circa lo 0.3-0.5% della popolazione ed è caratterizzata da capillari dilatati e fragili che predispongono a convulsioni, deficit neurologici e fatali emorragie intracerebrali. CCM è una malattia genetica che può insorgere in modo sporadico o essere ereditata con modalità di trasmissione autosomica dominante. La causa è stata identificata in mutazioni che determinano la perdita di tre geni, KRIT1 (CCM1), CCM2

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31

Huang, Yun. "Integration of Extracellular and Intracellular Calcium Signals: Roles of Calcium-Sensing Receptor (CASR), Calmodulin and Stromal Interaction Molecule 1 (STIM1)." Atlanta, Ga. : Georgia State University, 2008. http://digitalarchive.gsu.edu/chemistry_diss/28/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from title page (Digital Archive@GSU, viewed July 1, 2010) Jenny J. Yang, committee chair; Edward Brown, Giovanni Gadda, Zhi-ren Liu, committee members. Includes bibliographical references (p. 230-258).

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32

Mennour, Sabrina. "Activité de liaison à l’ARN des protéines de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase) dans le mélanome LncRNA-Mediated Protein-Protein Scaffolding in Intracellular Signal Transduction Pathways." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL062.

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Des études récentes ont souligné l'importance des ARN dans la régulation des interactions protéine-protéine. En permettant l'assemblage de complexes protéiques nucléaires, les ARN non codants agissent comme des échafaudages et favorisent ainsi les interactions protéine-protéine afin de réguler l'état de la chromatine. Les ARN sont également capables d’interagir avec des protéines pour en moduler leurs activités, leurs interactions ou encore leurs localisations. Cependant, le rôle potentiel des ARN dans la régulation des interactions protéine-protéine dans les principales voies de transduction

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33

Rico, Bautista Elizabeth. "Negative regulation of growth hormone (GH) signaling /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-184-9/.

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34

Gatlin, Jesse C. "Eicosanoid-mediated repellent signaling in the nerve growth cone : a role for the PKC substrate MARCKS /." Connect to full text at ProQuest Digital Dissertations. IP filtered, 2005.

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Thesis (Ph.D. in Cell and Developmental Biology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 123-141). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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35

Del, Río Iñiguez Iratxe. "Intracellular vesicle traffic, immunological synapse and T cell activation. Modulation by Human Immunodeficiency Virus type 1 Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T cell activation Rab11-FIP3 regulation of Lck endosomal traffic controls TCR signal transduction." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS561.

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La formation et les fonctions de la synapse immunologique sont le résultat d’un processus de polarisation cellulaire du lymphocyte T. Ce processus dépend de l’action coordonnée du cytosquelette d’actine et de microtubules, et du trafic vésiculaire intracellulaire. Le récepteur T ainsi que des protéines impliquées dans sa signalisation intracellulaire sont associés à la membrane plasmique et à des compartiments vésiculaires endosomiaux, et circulent en continu entre ces deux localisations. Je montre dans cette thèse que la tyrosine kinase Lck et la GTPase Rac1 sont associés aux endosomes exprim

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36

Sammons, Wendy L. "Generation and characterization of an attenuated mutant in a response-regulator gene of Francisella tularensis live vaccine strain (LVS)." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002268.

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37

Aggarwal, Kamna. "A View of the IMD Pathway from the RHIM." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/463.

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Innate immunity is the first line of defense against invading pathogens. It functions to eliminate pathogens and also to control infections. The innate immune response is also important for the development of pathogen-specific adaptive immune responses. As a result, the study of innate immune signaling pathways is crucial for understanding the interactions between host and pathogen. Unlike mammals, insects lack a classical adaptive immune response and rely mostly on innate immune responses. Innate immune mechanisms have been widely studied in the fruit fly, Drosophila melanogaster. The genetic

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38

Girard, Emmanuelle. "Caractérisation de nouveaux régulateurs du transport intracellulaire du cholestérol : mise en évidence du rôle de la dynamine et des GTPases Rab7 et Rab9." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00923162.

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Le transport intracellulaire du cholestérol et sa distribution correcte au niveau des différentes membranes sont essentiels pour assurer de nombreuses fonctions cellulaires. Malgré l'importance de ce transport les mécanismes de sa régulation restent encore mal connus. L'objectif de cette thèse était de mieux caractériser les acteurs du transport intracellulaire du cholestérol. Dans ce contexte, nous nous sommes intéressés à deux acteurs de ce transport : la dynamine et les Rab GTPases. Dans la première partie de la thèse nous avons utilisé le dynasore, un inhibiteur pharmacologique de la dynam

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39

Pelletier, Nadine. "Régulation des gènes C/EBPS par des voies de signalisation intracellulaire dans les cellules épithéliales intestinales." Mémoire, Université de Sherbrooke, 1996. http://savoirs.usherbrooke.ca/handle/11143/3110.

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Nous avons utilisé la lignée épithéliale intestinale de crypte de rat IEC-6 afin de mieux comprendre le rôle des C/EBPs dans la différenciation et la prolifération de l'intestin. Nous avons vérifié l'expression des ARNm de C/EBP$\alpha$, C/EBP$\beta$ et C/EBP$\delta$ suite à la stimulation des cellules IEC-6 par la forskoline et l'IBMX qui stimulent la PKA, le TPA qui stimule la PKC et la thapsigargine qui augmente la concentration de Ca$\sp{2+}$ cytoplasmique. La forskoline et l'IBMX induisent les niveaux d'ARNm des trois C/EBPs avec différentes cinétiques tandis que le TPA induit seulement l

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40

Dinerstein-Cali, Hélène. "Etude des molecules impliquees dans la transduction du signal du recepteur de l'hormone de croissance (doctorat : endocrinologie et interactions cellulaires)." Paris 11, 2000. http://www.theses.fr/2000PA11T005.

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41

Nissen, Johan. "Fonction de coactivateur in vivo et in vitro : lien entre la signalisation intracellulaire et la régulation génique." Montpellier 2, 2001. http://www.theses.fr/2001MON20048.

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42

Ichas, François. "La mitochondrie, organelle excitable : participation active à la signalisation calcique intracellulaire." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28475.

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43

Kiefer, Céline. "Mécanisme cinétique et moléculaire de CD38/NAD+glycohydrolase en relation avec la signalisation intracellulaire." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13048.

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Le CD38/NAD+glycohydrolase (EC 3. 2. 2. 5 et 3. 2. 2. 6), conservé dans l'évolution, est à la fois une glycoprotéine transmembranaire de type II qui possède des propriétés de signalisation notamment chez les lymphocytes et d'adhésion cellulaire et une ectoenzyme qui transforme le nicotinamide adénine dinucléotide (NAD+) en ADP-ribose cyclique (ADPRc), un second messager impliqué dans la mobilisation du calcium intracellulaire dans une variété de cellules aussi bien chez les mammifères que chez les plantes et les invertébrés. La question posée était de savoir si l'activité catalytique du CD38/N

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Descamps, Simon. "Mise en évidence du rôle du Nerve Growth Factor dans le cancer du sein : effets biologiques et signalisation intracellulaire." Lille 1, 2000. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2000/50376-2000-129.pdf.

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Le Nerve Growth Factor (ngf) est le facteur de croissance neurotrophique par excellence. Nous avons démontré que le ngf est un puissant mitogène pour les cellules de cancer du sein mais qu'il n'a pas d'effet sur la croissance des cellules épithéliales normales. Nous avons également mis en évidence l'activité anti-apoptotique du ngf sur les cellules mammaires cancéreuses. Nous avons ensuite étudié les mécanismes de signalisations responsables de l'effet mitogène et de l'effet anti-apoptotique du ngf. Nos résultats démontrent que le ngf active les récepteurs trka et les map-kinases pour stimuler

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45

Tesz, Gregory J. "Role of MAP4K4 Signaling in Adipocyte and Macrophage Derived Inflammation: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/380.

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Human obesity is increasing globally at an impressive rate. The rise in obesity has led to an increase in diseases associated with obesity, such as type 2 diabetes. A major prerequisite for this disease is the development of insulin resistance in the muscle and adipose tissues. Interestingly, experiments in rodent models suggest that adipocytes and macrophages can profoundly influence the development of insulin resistance. Accordingly, the number of adipose tissue macrophages increases substantially during the development of obesity. Numerous research models have demonstrated that macrophages

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Neyraud, Vincent. "L'ubiquitination des GTPases Ral : Un nouveau mécanisme de régulation diu trafic intracellulaire de Ral et des micro-domaines menmbranaires lipidiques." Paris 11, 2010. http://www.theses.fr/2010PA11T085.

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47

Kretz, Carole. "Induction du LTR de VIH-1 dans des conditions de stress cellulaire : rôles de NF-κB et de l'état redox intracellulaire". Lyon 1, 1997. http://www.theses.fr/1997LYO10076.

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L'infection par vih-1 est caractérisée par une phase de latence clinique particulièrement longue. La progression de la maladie jusqu'au stade sida nécessite une forte activation de la réplication virale. Parmi les stimuli induisant cette activation, on trouve des stress cellulaires tels que choc thermique, choc oxydant ou irradiation aux uv. L'action de ces agents s'exerce sur la transcription du provirus et, pour certains, (tnfalpha, peroxyde d'hydrogene) a été corrélée à l'activation du facteur de transcription cellulaire nf-kappa b, capable de se lier en deux sites, au ltr de vih-1. Ce trav

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Launay, Sophie. "Etude des ATPases-Ca2+ de type SERCA lors de la différenciation hématopoiétique." Paris 5, 2000. http://www.theses.fr/2000PA05S001.

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L'activation cellulaire se traduit par un signal calcique, qui implique une libération puis une réincorporation de Ca²+ dans le réticulum endoplasmique (RE) par les récepteurs de l'inositol trisphosphate (R-IP3) et les SERCA (sarco/endoplasmic reticulum Ca²+-ATPase), respectivement. Afin d'avancer dans la compréhension de ce signal, nous avons focalisé notre attention sur le rôle des nouvelles formes de SERCA3 co-exprimées avec la forme SERCA2b dans les principales voies de l'hématopoïèse, modèle peu étudié jusqu'alors. Lors de l'activation lymphocytaire, nous avons observé que l'expression de

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Pasquet, Jean-Max. "Etude des signaux intracellulaires et des mécanismes impliqués dans l'activation des plaquettes sanguines humaines conduisant à l'exposition des phospholipides procoagulants et à l'émission de microparticules." Bordeaux 2, 1996. http://www.theses.fr/1996BOR28447.

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Abstract:

L'asymétrie des phospholipides membranaires des cellules eucaryotes est maintenue par l'activité d'une Mg2+-ATPase, l'aminophospholipide translocase. Les plaquettes sanguines perdent cette asymétrie par activation physiologique (thrombine et collagène) ou non-physiologique (ionophore calcique, inhibiteurs de Ca2+-ATPases, de tyrosine-kinases ou de tyrosine-phosphatases) et deviendraient procoagulantes. L'exposition des aminophospholipides serait due à l'activation d'un transporteur protéique spécifique : la "scramblase". La formation de microparticules consécutivement à l'exposition des aminop

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50

Bastin, Guillaume. "Les résidus cystéines en positions 2 et 12 de RGS4 influencent son trafic intracellulaire et ses fonctions." Thesis, Lille 1, 2013. http://www.theses.fr/2013LIL10003/document.

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Abstract:

Les protéines RGS (Regulator of G-protein Signaling) sont des inhibiteurs des voies de signalisation des protéines G. RGS4 atténue l’activité de protéines G dans plusieurs tissus tel que la diminution de son activité peut accroître la sévérité de la bradycardie, cardiomyopathies liées au diabète, l’invasion de cellule cancéreuse du sein, résistance à l’insuline et intolérance au glucose. RGS4 a été localisé à la membrane plasmique ainsi que dans des compartiments intracellulaires, cependant, son mode de trafique intracellulaire reste méconnu. En utilisant des outils de microscopie confocale su

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