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Dissertations / Theses on the topic 'Intracellular signals'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Nair, Prashant. "Signals involved in protein intracellular sorting /." Basel : [s.n.], 2005. http://edoc.unibas.ch/diss/DissB_6999.

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2

劉思恩 and See-yan Lau. "A study of intracellular signals of K-opioids in non-neuronal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31214290.

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3

Lau, See-yan. "A study of intracellular signals of K-opioids in non-neuronal cells /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19667139.

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4

Liu, Ke, University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Role of second messengers in controlling growth patterns of corneal epithelial cells." THESIS_CSTE_SFH_Liu_K.xml, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh

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5

Levings, Megan K. "Biological and biochemical analyses of the distinctive intracellular signals activated by interleukin-4." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0025/NQ38928.pdf.

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6

Raraty, Michael Gordon Thomas. "Cytosolic calcium signals and intracellular enzyme activation in the pathogenesis of acute pancreatitis." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250238.

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7

Bradley, J. "Analysis of the mechanisms responsible for the generation and decoding of intracellular calcium signals." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596849.

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In many cells, including hepatocytes, receptors coupled to phosphoinositide hydrolysis stimulate oscillatory changes in cytosolic [Ca<SUP>2+</SUP>] ([Ca<SUP>2+</SUP>]<SUB>i</SUB>). I have used two methods to examine the means whereby such [Ca<SUP>2+</SUP>]<SUB>i</SUB> transients are linked to the stimulation of glycogenolysis. By perifusing rat hepatocytes prelabelled with [<SUP>3</SUP>H]-glucose, I showed that phenylephrine increases the rate of [<SUP>3</SUP>H]-glucose release by 2-3 fold, and confirmed this effect using a colorimetric assay for glucose. When cultured hepatocytes were loaded

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8

Righetti, Karima Maria. "Study of Rsm/Gac post-transcriptional regulation by quorum sensing, extracellular and intracellular signals in Pseugomonas aeruginosa." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/13853/.

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Bacteria have evolved ways to sense and respond to changes in their population density through quorum sensing (QS) systems, and to adapt to changes in the extracellular environment through two component systems (TCS). In Pseudomonas aeruginosa, QS and the GacS/GacA TCS are global regulatory systems that modulate the expression of virulence genes at the transcriptional and post-transcriptional level, respectively. Although in P. aeruginosa the QS network has been extensively characterized, the way the Gac/Rsm global regulatory system is regulated is still unclear. The study of QS and Gac/Rsm ne

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9

Huang, Yun. "Integration of Extracellular and Intracellular Calcium Signals: Roles of Calcium-Sensing Receptor (CASR), Calmodulin and Stromal Interaction Molecule 1 (STIM1)." Atlanta, Ga. : Georgia State University, 2008. http://digitalarchive.gsu.edu/chemistry_diss/28/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from title page (Digital Archive@GSU, viewed July 1, 2010) Jenny J. Yang, committee chair; Edward Brown, Giovanni Gadda, Zhi-ren Liu, committee members. Includes bibliographical references (p. 230-258).

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10

Lemaire, Mathieu. "Intracellular signals underlying the inductive effects of agrin during neuromuscular junction formation : study on the roles of ras and Shc." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0030/MQ64388.pdf.

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11

Rinis, Natalie [Verfasser], Gerhard [Akademischer Betreuer] Müller-Newen, and Björn [Akademischer Betreuer] Usadel. "Characterization and localization of intracellular signals emanating from an oncogenic mutant of the cytokine receptor Gp130 / Natalie Rinis ; Gerhard Müller-Newen, Björn Usadel." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1127531115/34.

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12

Liu, Ke. "Role of second messengers in controlling growth patterns of corneal epithelial cells." Thesis, View thesis, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh

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13

McKay, Jodi Ho-Jung. "HRas intracellular trafficking and signal transduction." [Ames, Iowa : Iowa State University], 2007.

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14

Legewie, Stefan. "Systems biological analyses of intracellular signal transduction." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16018.

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An der Interpretation extrazellulärer Signale beteiligte Regulationsnetzwerke sind von zentraler Bedeutung für alle Organismen. Extrazelluläre Signale werden gewöhnlich durch enzymatische Kaskaden innerhalb weniger Minuten in den Zellkern weitergeleitet, wo sie langsame Änderungen der Genexpression bewirken und so das Schicksal der Zelle beeinflussen. Im ersten Teil der Arbeit wird durch mathematische Modellierung untersucht, wie die MAPK Kaskade Signale von der Zellmembran in den Kern weiterleitet. Es wurden Netzwerkeigenschaften herausgearbeitet, die verhindern, dass die MAPK Kaskade fälschl

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15

Hao, Baixia, and 郝佰侠. "Regulatory and functional studies of store-operated calcium entry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196486.

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Ca2+ signaling is essential for a wide variety of cellular activities, ranging from short term activities, such as synaptic and muscle contraction, to long term processes, such as proliferation and differentiation. Store-operated Ca2+ entry (SOCE), an important Ca2+ influx pathway in non-excitable cells, well coordinates Ca2+ release from ER and Ca2+ influx through plasma membrane. STIM1 and Orai1, serving as ER Ca2+ sensor and pore forming subunit, respectively, are the two essential components of SOCE machinery. In addition to activate Orai1 channel, studies have shown that STIM1 regulates o

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16

Kemp, Daniel M. "Reporter gene analysis of regulatory mechanisms in cAMP signalling." Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310202.

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17

Juventin, Maxime. "Can the respiratory rhythm be a global signal promoting long-range communication in the brain?" Thesis, Lyon, 2021. https://tel.archives-ouvertes.fr/tel-03789626.

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Le cerveau est le siège d’une activité rythmique intense, chaque aire cérébrale exprimant un ou plusieurs rythmes. Une question centrale en neurosciences est de comprendre comment ces activités rythmiques peuvent se coordonner à travers des zones très distantes du cerveau pour résoudre des fonctions aussi complexes que la perception de l’environnement, des réponses motrices adaptées ou la formation de mémoires. Une possibilité est que le système utilise une référence temporelle commune, sorte d’horloge centrale, à partir de laquelle les différents réseaux neuronaux impliqués dans une fonction

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18

Lidder, Sukhwinderjit. "Involvement of cortactin, Crk and Eps8 as intracellular signal transducers of the hepatocyte growth factor signal." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411383.

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19

Bottomley, Matthew James. "Biophysical studies of intracellular signal transduction proteins : investigating the structure-function relationship." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286570.

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20

Campion, Katherine. "Characterisation of calcium-sensing receptor extracellular pH sensitivity and intracellular signal integration." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/characterisation-of-calciumsensing-receptor-extracellular-ph-sensitivity-and-intracellular-signal-integration(e11adf01-4748-42ed-8679-f8b990d79dea).html.

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Parathyroid hormone (PTH) secretion maintains free-ionised extracellular calcium (Ca2+o) homeostasis under the control of the calcium-sensing receptor (CaR). In humans and dogs, blood acidosis and alkalosis is associated with increased or suppressed PTH secretion respectively. Furthermore, large (1.0 pH unit) changes in extracellular pH (pHo) alter Ca2+o sensitivity of the CaR in CaR-transfected HEK-293 cells (CaR-HEK). Indeed, it has been found in this laboratory that even pathophysiological acidosis (pH 7.2) renders CaR less sensitive to Ca2+o while pathophysiological alkalosis (pH 7.6) incr

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21

Kawano, Yuichi. "Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3593-9/.

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22

Zhong, Zhihui. "Proinsulin c-peptide : membrane interactions and intracellular signaling /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-886-6.

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23

Sadreev, Ildar. "Mathematical modelling of inter- and intracellular signal transduction : the regulatory role of multisite interactions." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/21212.

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Signalling processes regulate various aspects of living cells via modulation of protein activity. The interactions between the signalling proteins can occur at single or multiple sites. Although single site protein interactions are relatively easy to understand, these rarely occur in living systems. It is therefore important to investigate multisite interactions. Despite the recent progress in experimental studies, the underlying molecular mechanisms and molecular functions of the multisite interactions are still not clear and therefore require systems approaches for deeper understanding, for

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24

Öberg, Camilla. "The life and death of the notch intracellular domain /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-464-X/.

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25

Li, Sen, and 李森. "Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46940546.

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26

Tong, Chun-kit Benjamin, and 唐俊傑. "Molecular mechanism of disrupted capacitative calcium entry in familial Alzheimer's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205870.

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Presenilin (PS) is the catalytic subunit of the gamma-secretase which is responsible for the cleavage of amyloid precursor protein to form beta amyloid (Aβ). Mutations in PS cause familial Alzheimer’s disease (FAD) by increasing the Aβ plaques formation in the brain and thereby induce neurodegeneration. Apart from this, FAD-linked PS mutations have been demonstrated to disrupt cellular calcium (Ca2+) homeostasis. Ca2+is a vital secondary messenger that involved in various neurophysiological functions, including memory, learning, and neuroplasticity and mounting evidence suggesting that Ca2+dys

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27

Thompson, Lauren. "Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/253.

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Nicotine is the primary addictive substance in tobacco, and most smokers who quit will relapse within a year. Evidence shows that cigarette craving increases over time, termed “incubation.” The purpose of these studies was to see if protracted abstinence from chronic nicotine increases rat self-administration, an animal model with good face validity for human tobacco use, and if nicotine self-administration during daily exposure/after 8+ days of abstinence is regulated by extracellular signal-regulated kinase (ERK) signaling in the nucleus accumbens (NAc) shell or anterior cingulate cortex (PF

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28

Chan, Ming Hang (Stanley), and stanley chan@baker edu au. "Investigation of The Intracellular Signalling Pathway for Interleukin-6 Gene Expression in Skeletal Muscle." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080206.091026.

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29

Webb, Dominic-Luc. "Temporal monitoring of intracellular Ca²⁺ signaling and origins of Ca²⁺ oscillations /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-741-3/.

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30

Pasley, William. "Intracellular pH, the Proximate Signal for Cell Volume Changes that are Mediated by the Actin Cytoskeleton." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1231.

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The relationship between initial intracellular pH (pHi) and associated cell volume change was investigated by simultaneous measurement of pHi and cell volume with fluorescence imaging in polarized fungiform taste receptor cells (TRCs) loaded with BCECF in vitro. Ammonium pulses caused a brief, reversible alkalinization in pHi and induced cell swelling. Sodium-acetate pulses reversible decreased TRC pHi and induced cell shrinkage. Removal weak acids and return to Control Ringer's solution (CR) causedTRC pHi and volume to overshoot baseline levels before fully recovering. Replacing CR with zero-

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31

Hassan, Mohamed. "Interference of Hepatitis C virus (HCV) core protein with intracellular signal transduction processes in liver cells /." Aachen : Shaker, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012995533&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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32

Bard, Frédéric. "Les transducteurs du signal src, cbl et cas et le trafic vesiculaire intracellulaire." Lyon, École normale supérieure (sciences), 1999. http://www.theses.fr/1999ENSL0131.

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Src, cbl et p 130cas sont lies a la transduction du signal issu des recepteurs aux facteurs de croissance et des integrines. Src est une tyrosine kinase regulant l'activite mitogenique, la motilite, le cytosquelette d'actine et peut-etre aussi le trafic vesiculaire des cellules. Cbl est un adaptateur multiple et un regulateur negatif des recepteurs a tyrosine kinase dont elle catalyse l'ubiquitination et l'orientation vers une degradation lysosomiale. L'observation par immunofluorescence en microscopie confocale (cif) de cellules cho, d'osteoclastes et de neurones revele cbl au niveau du golgi

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33

Al-Khalili, Lubna. "Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-866-1/.

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34

Hui, Xin [Verfasser], and Peter [Akademischer Betreuer] Lipp. "Protein Kinase C, the Spatial and Temporal Modulator of Intracellular Signal Transduction / Xin Hui. Betreuer: Peter Lipp." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1072409984/34.

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35

Teyssier, Catherine. "Mécanisme de l'interférence transcriptionnelle entre le récepteur des oestrogènes et les facteurs AP-1." Montpellier 1, 2000. http://www.theses.fr/2000MON1T007.

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36

Coudronnière, Nolwenn. "Régulation du cycle de réplication du virus de l'immunodéficience humaine de type (vih-1) par des signaux transmis par la molécule cd4." Montpellier 1, 1998. http://www.theses.fr/1998MON1T008.

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37

DA, SILVA CORREIA JEAN. "Les voies de signalisation intracellulaires mediees par les proteines kinases activees par les facteurs de stress, p38 et jnk : caracterisation, biologie et role dans la regulation de la transcription (doctorat : pharmacologie et pharmacochimie)." Strasbourg 1, 1998. http://www.theses.fr/1998STR15081.

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38

Hung, Chun-hin, and 孔進軒. "Effect of novel Chinese specific presenilin-1 V97L mutation on intracellular calcium homeostasis in human neuroblastoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193533.

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Presenilin-1 (PS1) mutations caused by the PSEN1 gene mutations are the major cause of early onset familial Alzheimer’s disease (EOFAD). Two Chinesespecific EOFAD related PS1 mutations, V97L and A136G, have been found. Studies suggested that V97L mutation lead to the overexpression of Aβ42 and tau hyperphosphorylation, which are the major hallmarks of Alzheimer’s disease (AD), while properties of A136G were unclear. Since calcium dysregulation was suggested to play an important role in AD, the research project investigated if V97L and A136G mutations also lead to altered endoplasmic reticulum

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39

Matos, Pinto Thiago. "Computational models of intracellular signalling and synaptic plasticity induction in the cerebellum." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11560.

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Many molecules and the complex interactions between them underlie plasticity in the cerebellum. However, the exact relationship between cerebellar plasticity and the different signalling cascades remains unclear. Calcium-calmodulin dependent protein kinase II (CaMKII) regulates many forms of synaptic plasticity, but very little is known about its function during plasticity induction in the cerebellum. The aim of this thesis is to contribute to a better understanding of the molecular mechanisms that regulate the induction of synaptic plasticity in cerebellar Purkinje cells (PCs). The focus of t

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40

Ontiveros, Steven J. "Intracellular trafficking of the hantaviral nucleocapsid protein and its function in modulation of immune signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/ontiveros.pdf.

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41

Dinerstein-Cali, Hélène. "Etude des molecules impliquees dans la transduction du signal du recepteur de l'hormone de croissance (doctorat : endocrinologie et interactions cellulaires)." Paris 11, 2000. http://www.theses.fr/2000PA11T005.

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42

Ng, Dominic Chi Hiung. "Characterizing intracellular signaling mechanisms involved in the progression of cardiac hypertrophy and failure : involvement of JAK/STAT and MAPK pathways." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2003. http://theses.library.uwa.edu.au/adt-WU2003.0032.

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[Truncated abstract] The innate ability of the heart to compensate for an increase in workload as a result of disease or injury, through an increase in size and mass is known as cardiac hypertrophy. The hypertrophy of the heart compensates for an increase in workload with an increase in cardiac output. However, excessive hypertrophy can result in cardiac dysfunction and substantially increases the risk of cardiac failure and mortality. The molecular mechanisms that regulate the development of cardiac hypertrophy and cardiac failure are not entirely understood. Traditionally, the G-protein Cou

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43

Ichas, François. "La mitochondrie, organelle excitable : participation active à la signalisation calcique intracellulaire." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28475.

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44

Girard, Emmanuelle. "Caractérisation de nouveaux régulateurs du transport intracellulaire du cholestérol : mise en évidence du rôle de la dynamine et des GTPases Rab7 et Rab9." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00923162.

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Le transport intracellulaire du cholestérol et sa distribution correcte au niveau des différentes membranes sont essentiels pour assurer de nombreuses fonctions cellulaires. Malgré l'importance de ce transport les mécanismes de sa régulation restent encore mal connus. L'objectif de cette thèse était de mieux caractériser les acteurs du transport intracellulaire du cholestérol. Dans ce contexte, nous nous sommes intéressés à deux acteurs de ce transport : la dynamine et les Rab GTPases. Dans la première partie de la thèse nous avons utilisé le dynasore, un inhibiteur pharmacologique de la dynam

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45

Pelletier, Nadine. "Régulation des gènes C/EBPS par des voies de signalisation intracellulaire dans les cellules épithéliales intestinales." Mémoire, Université de Sherbrooke, 1996. http://savoirs.usherbrooke.ca/handle/11143/3110.

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Nous avons utilisé la lignée épithéliale intestinale de crypte de rat IEC-6 afin de mieux comprendre le rôle des C/EBPs dans la différenciation et la prolifération de l'intestin. Nous avons vérifié l'expression des ARNm de C/EBP$\alpha$, C/EBP$\beta$ et C/EBP$\delta$ suite à la stimulation des cellules IEC-6 par la forskoline et l'IBMX qui stimulent la PKA, le TPA qui stimule la PKC et la thapsigargine qui augmente la concentration de Ca$\sp{2+}$ cytoplasmique. La forskoline et l'IBMX induisent les niveaux d'ARNm des trois C/EBPs avec différentes cinétiques tandis que le TPA induit seulement l

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46

Arastoo, Mohammed. "Characterisation of phospholipase C-η enzymes and their relevance to disease". Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/15698.

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Phospholipase C enzymes are a class of enzymes that catalyse the cleavage of the membrane phospholipid, phosphatidylinositol bisphosphate (PtdIns(4,5)P₂) into the second messengers, inositol trisphosphate (Ins(4,5)P₃) and diacylglycerol (DAG). Six classes of PLC enzymes have been identified based on their structure and mechanism of activation. PLCηs are the most recently identified family and consist of two isozymes, PLCη1 and PLCη2. The aim of this thesis is to further understand the mechanisms of PLCη activation, the role of PLCη2 in relation to neuritogenesis and their roles in certain dise

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47

Waxman, Joshua S. "Functions of the Dapper family of Dishevelled-interacting proteins in Xenopus and zebrafish /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5062.

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48

Kinkl, Norbert. "Mechanisms of action of fibroblast growth factor 2 (FGF2) in rat retinal cells : photoreceptor survival and intracellular signaling." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13166.

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La dégénérescence des photorécepteurs est à l'origine de nombreuses pathologies rétiniennes aboutissant à une malvoyance voire à la cécité. Les facteurs neurotrophiques représentent une approche thérapeutique potentielle. Au cours de cette thèse nous nous sommes intéressés aux mécanismes d'actions in vitro d'un facteur neurotrophique exprimé dans la rétine, le FGF2. Afin d'étudier les effets directs du FGF2 sur la survie des photorécepteurs, nous avons mis au point un nouveau modèle de culture pure en photorécepteurs à partir de rétine jeune de rat. La pureté en photorécepteurs des cultures es

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49

LAGAUD, GUY. "Mecanisme de couplage entre les recepteurs a l'atp et a la noradrenaline, signal calcique et contraction dans les arteres de resistance : effets du gmp c." Strasbourg 1, 1996. http://www.theses.fr/1996STR15071.

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50

Davezac, Noélie. "La phosphatase CDC25B: bases moléculaires de sa localisation intracellulaire et recherche de nouveaux partenaires." Phd thesis, Université Paul Sabatier - Toulouse III, 2001. http://tel.archives-ouvertes.fr/tel-00010040.

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La progression des cellules dans le cycle cellulaire est gouvernée par une famille de complexes à activité protéine kinase : les complexes CDK/cycline. L'activité de ces complexes est régulée notamment par la déphosphorylation activatrice de résidus tyrosine et thréonine par les phosphatases à double spécificité CDC25. Trois phosphatases CDC25 ont été identifiées dans les cellules de mammifères, et lors de notre travail, nous avons étudié la phosphatase CDC25B. Dans les cellules d'adénocarcinome humain (HeLa), nous avons montré que CDC25B présente une localisation nucléaire ou cytoplasmique st

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