Academic literature on the topic 'Intragenomic rearrangement'

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Journal articles on the topic "Intragenomic rearrangement"

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Leppik, Ludmila, Karin Gunst, Matti Lehtinen, Joakim Dillner, Karin Streker, and Ethel-Michele de Villiers. "In Vivo and In Vitro Intragenomic Rearrangement of TT Viruses." Journal of Virology 81, no. 17 (2007): 9346–56. http://dx.doi.org/10.1128/jvi.00781-07.

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ABSTRACT The in vitro replication of the Torque teno virus (TT virus) tth8 full-length genome and particle formation in a Hodgkin's lymphoma-derived cell line after transfection with cloned viral DNA were demonstrated. Analyses of the transcription patterns of tth8 and tth7 TT virus isolates in a number of lymphoma and T-cell leukemia cell lines indicated differential additional splicing events and intragenomic rearrangement generating open reading frames which could not be deducted from the genomic sequence. We also demonstrated the presence of rearranged TT virus genomes in vivo in sera take
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Pohl, Mary Ann, Sabine Kienesberger, and Martin J. Blaser. "Novel Functions for Glycosyltransferases Jhp0562 and GalT in Lewis Antigen Synthesis and Variation in Helicobacter pylori." Infection and Immunity 80, no. 4 (2012): 1593–605. http://dx.doi.org/10.1128/iai.00032-12.

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ABSTRACTLewis (Le) antigens are fucosylated oligosaccharides present in theHelicobacter pylorilipopolysaccharide. Expression of these antigens is believed to be important forH. pyloricolonization, since Le antigens also are expressed on the gastric epithelia in humans. A galactosyltransferase encoded by β-(1,3)galTis essential for production of type 1 (Leaand Leb) antigens. The upstream genejhp0562, which is present in many but not allH. pyloristrains, is homologous to β-(1,3)galTbut is of unknown function. BecauseH. pyloridemonstrates extensive intragenomic recombination, we hypothesized that
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Zattera, Michelle Louise, and Daniel Pacheco Bruschi. "Transposable Elements as a Source of Novel Repetitive DNA in the Eukaryote Genome." Cells 11, no. 21 (2022): 3373. http://dx.doi.org/10.3390/cells11213373.

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The impact of transposable elements (TEs) on the evolution of the eukaryote genome has been observed in a number of biological processes, such as the recruitment of the host’s gene expression network or the rearrangement of genome structure. However, TEs may also provide a substrate for the emergence of novel repetitive elements, which contribute to the generation of new genomic components during the course of the evolutionary process. In this review, we examine published descriptions of TEs that give rise to tandem sequences in an attempt to comprehend the relationship between TEs and the eme
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Pfister, Thomas, Keith W. Jones, and Eckard Wimmer. "A Cysteine-Rich Motif in Poliovirus Protein 2CATPaseIs Involved in RNA Replication and Binds Zinc In Vitro." Journal of Virology 74, no. 1 (2000): 334–43. http://dx.doi.org/10.1128/jvi.74.1.334-343.2000.

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ABSTRACT Protein 2CATPase of picornaviruses is involved in the rearrangement of host cell organelles, viral RNA replication, and encapsidation. However, the biochemical and molecular mechanisms by which 2CATPase engages in these processes are not known. To characterize functional domains of 2CATPase, we have focused on a cysteine-rich motif near the carboxy terminus of poliovirus 2CATPase. This region, which is well conserved among enteroviruses and rhinoviruses displaying an amino acid arrangement resembling zinc finger motifs, was studied by genetic and biochemical analyses. A mutation that
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Faddeeva-Vakhrusheva, Anna, Ken Kraaijeveld, Martijn F. L. Derks, et al. "Coping with living in the soil: the genome of the parthenogenetic springtail Folsomia candida." BMC Genomics 18, no. 1 (2017): 493. https://doi.org/10.1186/s12864-017-3852-x.

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<strong>Background: </strong> <i>Folsomia candida</i> is a model in soil biology, belonging to the family of Isotomidae, subclass Collembola. It reproduces parthenogenetically in the presence of <i>Wolbachia</i>, and exhibits remarkable physiological adaptations to stress. To better understand these features and adaptations to life in the soil, we studied its genome in the context of its parthenogenetic lifestyle.<strong>Results: </strong>We applied Pacific Bioscience sequencing and assembly to generate a reference genome for <i>F. candida</i> of 221.7 Mbp, comprising only 162 scaffolds. The c
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Eriksen, Kirsten T., Dorte Haubek, and Knud Poulsen. "Intragenomic recombination in the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans." Microbiology 151, no. 10 (2005): 3371–79. http://dx.doi.org/10.1099/mic.0.28193-0.

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The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans is strongly associated with aggressive periodontitis in adolescents of African descent. DNA fingerprinting using the frequently cutting restriction enzyme MspI and multilocus sequence typing (MLST) showed that five strains of this clone were genetically virtually identical, although ribotyping of the six rrn genes and EcoRI RFLP analysis of the seven IS150-like elements revealed differences. PCR analyses demonstrated that these multi-copy sequences are subject to intragenomic homologous recombination, resulting in transloc
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Searle, Jeremy B., and Fernando Pardo-Manuel de Villena. "Meiotic Drive and Speciation." Annual Review of Genetics 58, no. 1 (2024): 341–63. http://dx.doi.org/10.1146/annurev-genet-111523-102603.

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Meiotic drive is the biased transmission of alleles from heterozygotes, contrary to Mendel's laws, and reflects intragenomic conflict rather than organism-level Darwinian selection. Theory has been developed as to how centromeric properties can promote female meiotic drive and how conflict between the X and Y chromosomes in males can promote male meiotic drive. There are empirical data that fit both the centromere drive and sex chromosome drive models. Sex chromosome drive may have relevance to speciation through the buildup of Dobzhansky-Muller incompatibilities involving drive and suppressor
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Kang, Josephine, and Martin J. Blaser. "UvrD Helicase Suppresses Recombination and DNA Damage-Induced Deletions." Journal of Bacteriology 188, no. 15 (2006): 5450–59. http://dx.doi.org/10.1128/jb.00275-06.

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ABSTRACT UvrD, a highly conserved helicase involved in mismatch repair, nucleotide excision repair (NER), and recombinational repair, plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species. In this report, we focus on the UvrD homolog in Helicobacter pylori, a genetically diverse organism that lacks many known DNA repair proteins, including those involved in mismatch repair and recombinational repair, and that is noted for high levels of inter- and intragenomic recombination and mutation. H. pylori contains numerous DNA repeats in
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Tomaszewska, Paulina, and Romuald Kosina. "Cytogenetic events in the endosperm of amphiploid Avena magna × A. longiglumis." Journal of Plant Research 134, no. 5 (2021): 1047–60. http://dx.doi.org/10.1007/s10265-021-01314-3.

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AbstractThis study analysed cytogenetic events occurring in the syncytial endosperm of the Avena magna H. C. Murphy &amp; Terrell × Avena longiglumis Durieu amphiploid, which is a product of two wild species having different genomes. Selection through the elimination of chromosomes and their fragments, including those translocated, decreased the level of ploidy in the endosperm below the expected 3n, leading to the modal number close to 2n. During intergenomic translocations, fragments of the heterochromatin-rich C-genome were transferred to the D and Al genomes. Terminal and non-reciprocal ex
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Amosova, Alexandra V., Alexander A. Gnutikov, Alexander V. Rodionov, et al. "Genome Variability in Artificial Allopolyploid Hybrids of Avena sativa L. and Avena macrostachya Balansa ex Coss. et Durieu Based on Marker Sequences of Satellite DNA and the ITS1–5.8S rDNA Region." International Journal of Molecular Sciences 25, no. 10 (2024): 5534. http://dx.doi.org/10.3390/ijms25105534.

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Artificial hybrids between cultivated Avena species and wild Avena macrostachya that possess genes for resistance to biotic and abiotic stresses can be important for oat breeding. For the first time, a comprehensive study of genomes of artificial fertile hybrids Avena sativa × Avena macrostachya and their parental species was carried out based on the chromosome FISH mapping of satellite DNA sequences (satDNAs) and also analysis of intragenomic polymorphism in the 18S–ITS1–5.8S rDNA region, using NGS data. Chromosome distribution patterns of marker satDNAs allowed us to identify all chromosomes
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Book chapters on the topic "Intragenomic rearrangement"

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de Villiers, E. M., R. Kimmel, L. Leppik, and K. Gunst. "Intragenomic Rearrangement in TT Viruses: A Possible Role in the Pathogenesis of Disease." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-70972-5_6.

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Conference papers on the topic "Intragenomic rearrangement"

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Matthews, R. J., D. S. Anson, I. R. Peake, and A. L. Bloom. "GENE DELETIONS IN THE FACTOR IX LOCUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643871.

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Previous studies have indicated that the majority of haemophilia B patients who produce anti-factor IX inhibitors (antibodies) have some kind of deletion of the factor IX gene. We have analysed DNA from nine haemophilia B inhibitor patients using the Southern blotting method and hybridisation with (i) factor IX cDNA and intragenomic probes (ii) probes originating from flanking sequences up to 60kb 5' and 170kb 3' to the factor IX gene that have been isolated by gene walking experiments (D.S.Anson and G.G.Brownlee, unpublished observations).Two patients who are brothers (haemophilia B (Chicago
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