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Journal articles on the topic 'Intramolecular dehydrogenative coupling (IDC)'

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1

Kumar, Nivesh, Santanu Ghosh, Subhajit Bhunia, and Alakesh Bisai. "Synthesis of 2-oxindoles via 'transition-metal-free' intramolecular dehydrogenative coupling (IDC) of sp2 C–H and sp3 C–H bonds." Beilstein Journal of Organic Chemistry 12 (June 8, 2016): 1153–69. http://dx.doi.org/10.3762/bjoc.12.111.

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The synthesis of a variety of 2-oxindoles bearing an all-carbon quaternary center at the pseudo benzylic position has been achieved via a ‘transition-metal-free’ intramolecular dehydrogenative coupling (IDC). The construction of 2-oxindole moieties was carried out through formation of carbon–carbon bonds using KOt-Bu-catalyzed one pot C-alkylation of β-N-arylamido esters with alkyl halides followed by a dehydrogenative coupling. Experimental evidences indicated toward a radical-mediated path for this reaction.
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2

Saina, Shaheeda M. K., Kumar Nivesh, Maity Arindam, and Bisai Alakesh. "Synthesis of fluorinated 2-oxindoles via intramolecular dehydrogenative coupling." Journal of Indian Chemical Society Vol. 97, No. 12a, Dec 2020 (2020): 2567–78. https://doi.org/10.5281/zenodo.5655879.

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Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal-462 066, Madhya Pradesh, India Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur-741 246, Nadia, West Bengal, India <em>E-mail:</em> alakesh@iiserkol.ac.in <em>Manuscript received online 14 November 2020, revised and accepted 20 December 2020</em> An expedient synthesis of fluorinated 2-oxindoles bearing an all carbon quaternary center at the pseudobenzylic position is envisioned under &ldquo;transition metal free&rdquo; intramolecular dehydroge
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3

Bhunia, Subhajit, Santanu Ghosh, Dhananjay Dey, and Alakesh Bisai. "DDQ-mediated Direct Intramolecular-Dehydrogenative-Coupling (IDC): Expeditious Approach to the Tetracyclic Core of Ergot Alkaloids." Organic Letters 15, no. 10 (2013): 2426–29. http://dx.doi.org/10.1021/ol400899e.

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4

Henry, Martyn, Mohamed Mostafa, and Andrew Sutherland. "Recent Advances in Transition-Metal-Catalyzed, Directed Aryl C–H/N–H Cross-Coupling Reactions." Synthesis 49, no. 20 (2017): 4586–98. http://dx.doi.org/10.1055/s-0036-1588536.

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Amination and amidation of aryl compounds using a transition-metal-catalyzed cross-coupling reaction typically involves prefunctionalization or preoxidation of either partner. In recent years, a new class of transition-metal-catalyzed cross-dehydrogenative coupling reaction has been developed for the direct formation of aryl C–N bonds. This short review highlights the substantial progress made for ortho-C–N bond formation via transition-metal-catalyzed chelation-directed aryl C–H activation and gives an overview of the challenges that remain for directed meta- and para-selective reactions.1 In
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5

Zhang, Liang, Michael Lepper, Michael Stark, et al. "Self-assembly and coverage dependent thermally induced conformational changes of Ni(ii)-meso-tetrakis (4-tert-butylphenyl) benzoporphyrin on Cu(111)." Physical Chemistry Chemical Physics 17, no. 19 (2015): 13066–73. http://dx.doi.org/10.1039/c5cp01490e.

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6

Song, Xianheng, Xiang Luo, Jianfei Sheng, et al. "Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins." RSC Advances 9, no. 30 (2019): 17391–98. http://dx.doi.org/10.1039/c9ra01909j.

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7

Wang, Pan, Shan Tang, and Aiwen Lei. "Electrochemical intramolecular dehydrogenative C–S bond formation for the synthesis of benzothiazoles." Green Chemistry 19, no. 9 (2017): 2092–95. http://dx.doi.org/10.1039/c7gc00468k.

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8

Firmansyah, Dikhi, Marzena Banasiewicz, and Daniel T. Gryko. "Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling." Organic & Biomolecular Chemistry 13, no. 5 (2015): 1367–74. http://dx.doi.org/10.1039/c4ob02383h.

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9

Wen, Li-Rong, Cheng-Cheng Zhou, Ming-Zhe Zhu, Shu-Guang Xie, Wei-Si Guo, and Ming Li. "Intramolecular dehydrogenative C–S bond coupling of thioamides to form 1,3-benzothiazines under metal-free conditions." Organic & Biomolecular Chemistry 17, no. 13 (2019): 3356–60. http://dx.doi.org/10.1039/c9ob00237e.

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10

Tripathi, Krishna N., Devalina Ray, and Ravi P. Singh. "Pd-Catalyzed regioselective intramolecular dehydrogenative C-5 cross coupling in anN-substituted pyrrole-azole system." Organic & Biomolecular Chemistry 15, no. 47 (2017): 10082–86. http://dx.doi.org/10.1039/c7ob02676e.

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11

Prendergast, Aisling M., Zhihan Zhang, Zhenyang Lin, and Gerard P. McGlacken. "Mechanistic studies on the palladium-catalyzed cross-dehydrogenative coupling of 4-phenoxy-2-coumarins: experimental and computational insights." Dalton Transactions 47, no. 17 (2018): 6049–53. http://dx.doi.org/10.1039/c8dt00842f.

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12

Shinde, Vikki N., Shiv Dhiman, Rangan Krishnan, Dalip Kumar, and Anil Kumar. "Synthesis of imidazopyridine-fused indoles via one-pot sequential Knoevenagel condensation and cross dehydrogenative coupling." Organic & Biomolecular Chemistry 16, no. 33 (2018): 6123–32. http://dx.doi.org/10.1039/c8ob01449c.

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13

Cheng, Chao, Wen-Wen Chen, Bin Xu, and Ming-Hua Xu. "Intramolecular cross dehydrogenative coupling of 4-substituted coumarins: rapid and efficient access to coumestans and indole[3,2-c]coumarins." Organic Chemistry Frontiers 3, no. 9 (2016): 1111–15. http://dx.doi.org/10.1039/c6qo00270f.

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A palladium-catalyzed highly efficient and atom-economical intramolecular cross dehydrogenative coupling (CDC) reaction to access fused polyheterocycles containing a coumarin nucleus has been developed.
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14

Tang, Jing, Shijun Zhao, Yuanyuan Wei, Zhengjun Quan, and Congde Huo. "CBr4 promoted intramolecular aerobic oxidative dehydrogenative arylation of aldehydes: application in the synthesis of xanthones and fluorenones." Organic & Biomolecular Chemistry 15, no. 7 (2017): 1589–92. http://dx.doi.org/10.1039/c7ob00080d.

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A carbon tetrabromide promoted intramolecular aerobic oxidative dehydrogenative coupling reaction has been developed to provide a straightforward ring closure protocol to furnish xanthones and fluorenones.
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15

Wu, Zheng-Jian, Shi-Rui Li, Hao Long, and Hai-Chao Xu. "Electrochemical dehydrogenative cyclization of 1,3-dicarbonyl compounds." Chemical Communications 54, no. 36 (2018): 4601–4. http://dx.doi.org/10.1039/c8cc02472c.

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16

Cui, Chun-Xiao, Jie Zhang, Zaozao Qiu, and Zuowei Xie. "Palladium-catalyzed intramolecular dehydrogenative coupling of BH and OH: synthesis of carborane-fused benzoxaboroles." Dalton Transactions 49, no. 5 (2020): 1380–83. http://dx.doi.org/10.1039/c9dt04553h.

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17

Chen, Kaili, Biao Gao, Yanguo Shang, Jianyao Du, Qinlan Gu, and Jinxin Wang. "I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones." Org. Biomol. Chem. 15, no. 41 (2017): 8770–79. http://dx.doi.org/10.1039/c7ob02038d.

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18

Zhao, Rongrong, Simiaomiao Wen, Hao Fu, Mengna Liu, Qixing Liu, and Haifeng Zhou. "Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen." Green Chemistry 24, no. 4 (2022): 1644–49. http://dx.doi.org/10.1039/d1gc04581d.

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A simple, efficient and clean intramolecular oxidative dehydrogenative coupling for the synthesis of dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones, and analogues promoted by bis(2-methoxyethyl)ether/O2 has been achieved.
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19

Aggarwal, Sakshi, Dasari Srinivas, Chinnabattigalla Sreenivasulu, and Gedu Satyanarayana. "Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans." RSC Advances 10, no. 37 (2020): 22264–72. http://dx.doi.org/10.1039/d0ra03071f.

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We have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. O<sub>2</sub> gas served as an oxidant and 3-aryl benzofurans were synthesized in good to very good yields.
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20

Wu, Xuesong, Mian Wang, Guangwu Zhang, Yan Zhao, Jianyi Wang, and Haibo Ge. "Copper-catalyzed diastereoselective aerobic intramolecular dehydrogenative coupling of hydrazones via sp3C–H functionalization." Chemical Science 6, no. 10 (2015): 5882–90. http://dx.doi.org/10.1039/c5sc01736j.

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21

Kumari, Santosh, S. M. Abdul Shakoor, Sadhika Khullar, Sanjay K. Mandal, and Rajeev Sakhuja. "An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp3)–N bond coupling." Organic & Biomolecular Chemistry 16, no. 17 (2018): 3220–28. http://dx.doi.org/10.1039/c8ob00586a.

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22

Nandwana, Nitesh Kumar, Kasiviswanadharaju Pericherla, Pinku Kaswan, and Anil Kumar. "Synthesis of novel azole-fused quinazolines via one-pot, sequential Ullmann-type coupling and intramolecular dehydrogenative C–N bonding." Organic & Biomolecular Chemistry 13, no. 10 (2015): 2947–50. http://dx.doi.org/10.1039/c4ob02375g.

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An efficient one-pot sequential procedure is described for the synthesis of novel azole-fused quinazolines through Ullmann-type coupling followed by cross dehydrogenative coupling of various azoles with 2-(2-bromophenyl)-1H-imidazole/benzimidazoles.
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23

Gu, Chang-Xue, Jian-Guo Liu, Wen-Wen Chen, and Ming-Hua Xu. "Facile synthesis of coumaronochromones through palladium-catalyzed intramolecular cross dehydrogenative coupling." Tetrahedron 85 (April 2021): 132048. http://dx.doi.org/10.1016/j.tet.2021.132048.

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24

Park, Ok-Kyung, Yong-Mun Choi, Jun Yeon Hwang, et al. "Defect healing of reduced graphene oxide via intramolecular cross-dehydrogenative coupling." Nanotechnology 24, no. 18 (2013): 185604. http://dx.doi.org/10.1088/0957-4484/24/18/185604.

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25

Ai, Liankun, Ibrahim Yusuf Ajibola, and Baolin Li. "Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C–O coupling reaction." RSC Advances 11, no. 57 (2021): 36305–9. http://dx.doi.org/10.1039/d1ra06985c.

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The construction of benzothieno[3,2-b]benzofurans via novel dehydrogenative C–H/O–H coupling reaction has been developed with excellent yields. Furthermore, three-to-six fused ring thienofuran compounds could be constructed.
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26

Li, Guangzhe, Chengdong Wang, Yueqing Li, et al. "Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with diverse carbon pronucleophiles: facile access to functionalized tetrahydroquinolines." Chemical Communications 56, no. 53 (2020): 7333–36. http://dx.doi.org/10.1039/d0cc02921a.

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27

Wang, Meng-Yue, Xue-Qing Zhu, Bao-Yin Zhao, Hong-Xia Zhang, Yong-Qiang Wang, and Qiong Jia. "Synthesis of 5,6-Dihydrophenanthridines via Palladium-Catalyzed Intramolecular Dehydrogenative Coupling of Two Aryl C−H Bonds." Molecules 28, no. 6 (2023): 2498. http://dx.doi.org/10.3390/molecules28062498.

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5,6-Dihydrophenanthridines are common aza heterocycle frameworks of natural products and pharmaceuticals. Herein, we reported the first palladium-catalyzed intramolecular C−H/C−H dehydrogenative coupling reaction of two simple arenes to generate 5,6-dihydrophenanthridines. The approach features a broad substrate scope and good tolerance of functional groups, offering an efficient alternative synthesis route for important 5,6-dihydrophenanthridine compounds.
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28

Zhang, Qiang, Lin-Yan Zhang, and Xian-Ying Shi. "Copper-Promoted Intramolecular Oxidative Dehydrogenation for Synthesizing Dihydroisocoumarins and Isocoumarins." Molecules 28, no. 17 (2023): 6319. http://dx.doi.org/10.3390/molecules28176319.

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Isocoumarins and dihydroisocoumarins are important skeletons with a wide range of biological activities, such as anti-bacterial, anti-allergy, anti-fungal, anti-tumor, and anti-HIV properties. Herein, we demonstrated divergent syntheses of isocoumarins and 3,4-dihydroisocoumarins by intramolecular dehydrogenative cyclization of 2-(3-oxobutyl) benzoic acids. This transformation undergoes Csp3–H bonds and O–H bonds coupling in air using copper salt. The reactions may undergo free radical process.
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29

Ray, Devalina, T. Manikandan, Arup Roy, Krishna N. Tripathi, and Ravi P. Singh. "Ligand-promoted intramolecular dehydrogenative cross-coupling using a Cu catalyst: direct access to polycyclic heteroarenes." Chemical Communications 51, no. 32 (2015): 7065–68. http://dx.doi.org/10.1039/c5cc01817j.

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30

Gupta, Vijay, V. U. Bhaskara Rao, Tamal Das, Kumar Vanka, and Ravi P. Singh. "Intramolecular Dehydrogenative Coupling of 2,3-Diaryl Acrylic Compounds: Access to Substituted Phenanthrenes." Journal of Organic Chemistry 81, no. 13 (2016): 5663–69. http://dx.doi.org/10.1021/acs.joc.6b00507.

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31

Baars, Hannah, Yuto Unoh, Takeshi Okada, et al. "Rhodium-catalyzed Intramolecular Dehydrogenative Aryl–Aryl Coupling Using Air as Terminal Oxidant." Chemistry Letters 43, no. 11 (2014): 1782–84. http://dx.doi.org/10.1246/cl.140690.

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32

Lessi, Marco, Antonio Lucci, Angela Cuzzola, and Fabio Bellina. "Imidazo-Fused Isoindoles by Pd(II)/Ag(I)-Promoted Intramolecular Dehydrogenative Coupling." European Journal of Organic Chemistry 2020, no. 7 (2020): 796–802. http://dx.doi.org/10.1002/ejoc.201901618.

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33

Barboza, Amanda Aline, Juliana Arantes Dantas, Guilherme Augusto de Melo Jardim, Marco Antonio Barbosa Ferreira, Mateus Oliveira Costa, and Attilio Chiavegatti. "Recent Advances in Palladium-Catalyzed Oxidative Couplings in the Synthesis/Functionalization of Cyclic Scaffolds Using Molecular Oxygen as the Sole Oxidant." Synthesis 54, no. 09 (2021): 2081–102. http://dx.doi.org/10.1055/a-1701-7397.

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AbstractOver the past years, Pd(II)-catalyzed oxidative couplings have enabled the construction of molecular scaffolds with high structural diversity via C–C, C–N and C–O bond-forming reactions. In contrast to the use of stoichiometric amounts of more common oxidants, such as metal salts (Cu and Ag) and benzoquinone derivatives, the use of molecular oxygen for the direct or indirect regeneration of Pd(II) species presents itself as a more viable alternative in terms of economy and sustainability. In this review, we describe recent advances on the development of Pd-catalyzed oxidative cyclizati
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34

Pereira, Kyle C., Ashley L. Porter, and Brenton DeBoef. "Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling." Tetrahedron Letters 55, no. 10 (2014): 1729–32. http://dx.doi.org/10.1016/j.tetlet.2014.01.103.

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35

Borpatra, Paran J., Mohit L. Deb, and Pranjal K. Baruah. "Visible light-promoted metal-free intramolecular cross dehydrogenative coupling approach to 1,3-oxazines." Tetrahedron Letters 58, no. 42 (2017): 4006–10. http://dx.doi.org/10.1016/j.tetlet.2017.09.018.

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36

Gao, Zhong‐Hua, Zi‐Hao Xia, Lei Dai, and Song Ye. "N‐Heterocyclic Carbene Catalyzed Photooxidation: Intramolecular Cross Dehydrogenative Coupling of Tetrahydroisoquinoline‐Tethered Aldehydes." Advanced Synthesis & Catalysis 362, no. 9 (2020): 1819–24. http://dx.doi.org/10.1002/adsc.202000164.

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37

Tang, Baoxin, and Ruimao Hua. "Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of ortho-Alkynyl-N-arylbenzamides for Access to Isoindolo[2,1-a]Indol-6-Ones." Molecules 27, no. 11 (2022): 3393. http://dx.doi.org/10.3390/molecules27113393.

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An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-a]indol-6-ones via CuI/Pd(OAc)2-catalyzed intramolecular hydroamidation of alkynyl group, and C-H dehydrogenative coupling of ortho-alkynyl-N-arylbenzamides has been developed. This transformation occurs with the use of oxygen as the oxidant, and water is the only by-product. The reaction shows a high tolerance to a variety of functional groups, and affords isoindolo[2,1-a]indol-6-ones in good to high yields.
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38

Bao, Hanyang, Xiaojun Hu, Jian Zhang, and Yunkui Liu. "Cu(0)/Selectfluor system-catalyzed intramolecular Csp2-H/Csp2-H cross-dehydrogenative coupling (CDC)." Tetrahedron 75, no. 42 (2019): 130533. http://dx.doi.org/10.1016/j.tet.2019.130533.

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39

Cheng, Chao, Wen-Wen Chen, Bin Xu, and Ming-Hua Xu. "Access to Indole-Fused Polyheterocycles via Pd-Catalyzed Base-Free Intramolecular Cross Dehydrogenative Coupling." Journal of Organic Chemistry 81, no. 22 (2016): 11501–7. http://dx.doi.org/10.1021/acs.joc.6b02160.

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40

Baars, Hannah, Yuto Unoh, Takeshi Okada, et al. "ChemInform Abstract: Rhodium-Catalyzed Intramolecular Dehydrogenative Aryl-Aryl Coupling Using Air as Terminal Oxidant." ChemInform 46, no. 20 (2015): no. http://dx.doi.org/10.1002/chin.201520105.

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41

Li, Han-ge, Yun-fei Liu, Jing-nan Cui, and Lei Shi. "Electrocatalytic intramolecular cross-dehydrogenative coupling for synthesis of fused heterocyclic compounds bearing tetrahydroisoquinoline core." Tetrahedron Letters 165-166 (July 2025): 155646. https://doi.org/10.1016/j.tetlet.2025.155646.

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42

Sun, Peng, Jiaojiao Yang, Zirui Song, et al. "Copper-Mediated One-Pot Synthesis of Indoles through Sequential Hydroamination and Cross-Dehydrogenative Coupling Reaction." Synthesis 52, no. 01 (2019): 75–84. http://dx.doi.org/10.1055/s-0039-1690240.

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Starting from simple anilines and ester arylpropiolates, an efficient one-pot synthesis of 2-arylindole-3-carboxylate derivatives has been developed through copper-mediated sequential hydroamination and cross-dehydrogenative coupling (CDC) reaction. The initial hydroamination of anilines to ester arylpropiolates in benzene can proceed in a stereoselective manner to give ester (Z)-3-(arylamino)acrylates in the presence of CuCl2/phenanthroline, KMnO4, and KHCO3 at 120 °C. Sequentially, these in situ functionalized adducts can undergo direct intramolecular oxidative alkenylation of aromatic C–H b
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43

Chen, Yu, Hairong Lyu, Yangjian Quan, and Zuowei Xie. "Fe-Catalyzed Intramolecular B–H/C–H Dehydrogenative Coupling: Synthesis of Carborane-Fused Nitrogen Heterocycles." Organic Letters 23, no. 11 (2021): 4163–67. http://dx.doi.org/10.1021/acs.orglett.1c01104.

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44

Yi, Chenyi, Shi-Xia Liu, Antonia Neels, Philippe Renaud, and Silvio Decurtins. "Preparation of Zwitterionic Hydroquinone-Fused [1,4]Oxazinium Derivatives via a Photoinduced Intramolecular Dehydrogenative-Coupling Reaction." Organic Letters 11, no. 23 (2009): 5530–33. http://dx.doi.org/10.1021/ol902355b.

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45

Chen, Jun, and Fatima Rashid Sheykhahmad. "Intramolecular cross‐dehydrogenative coupling of benzaldehyde derivatives: A novel and efficient route to benzocyclic ketones." Journal of the Chinese Chemical Society 67, no. 4 (2019): 638–45. http://dx.doi.org/10.1002/jccs.201900214.

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46

Wu, Xuesong, Mian Wang, Guangwu Zhang, Yan Zhao, Jianyi Wang, and Haibo Ge. "ChemInform Abstract: Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Coupling of Hydrazones via sp3C-H Functionalization." ChemInform 47, no. 7 (2016): no. http://dx.doi.org/10.1002/chin.201607149.

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47

Pereira, Kyle C., Ashley L. Porter, and Brenton DeBoef. "ChemInform Abstract: Intramolecular Arylation of Benzimidazoles via Pd(II)/Cu(I) Catalyzed Cross-Dehydrogenative Coupling." ChemInform 45, no. 32 (2014): no. http://dx.doi.org/10.1002/chin.201432148.

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48

Zhuang, Weihui, Jiaqi Zhang, Yanping Zheng, and Qiufeng Huang. "Rhodium-Catalyzed Oxidative Annulation of 2- or 7-Arylindoles with Alkenes/Alkynes Using Molecular Oxygen as the Sole Oxidant Enabled by Quaternary Ammonium Salt." Molecules 26, no. 17 (2021): 5329. http://dx.doi.org/10.3390/molecules26175329.

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Developing an efficient catalytic system using molecular oxygen as the oxidant for rhodium-catalyzed cross-dehydrogenative coupling remains highly desirable. Herein, rhodium-catalyzed oxidative annulation of 2- or 7-phenyl-1H-indoles with alkenes or alkynes to assemble valuable 6H-isoindolo[2,1-a]indoles, pyrrolo[3,2,1-de]phenanthridines, or indolo[2,1-a]isoquinolines using the atmospheric pressure of air as the sole oxidant enabled by quaternary ammonium salt has been accomplished. Mechanistic studies provided evidence for the fast intramolecular aza-Michael reaction and aerobic reoxidation o
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49

Li, Guangzhe, Guo Yu, Chengdong Wang, Taiki Morita, Xuhai Zhang, and Hiroyuki Nakamura. "Copper(i)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites." Organic & Biomolecular Chemistry 20, no. 1 (2022): 113–16. http://dx.doi.org/10.1039/d1ob02091a.

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A simple method for site-selective synthesis of 2-phosphonotetrahydroquinolines. Tetrahydroquinoline was constructed by a cyclization reaction and in the meantime the phosphoric acid (ester) group was introduced to the C2-position.
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50

Volvoikar, Prajesh S., and Santosh G. Tilve. "Iodine-Mediated Intramolecular Dehydrogenative Coupling: Synthesis of N-Alkylindolo[3,2-c]- and -[2,3-c]quinoline Iodides." Organic Letters 18, no. 5 (2016): 892–95. http://dx.doi.org/10.1021/acs.orglett.5b03392.

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