Academic literature on the topic 'Intramolecular Michael addition'

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Journal articles on the topic "Intramolecular Michael addition"

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Reddy, S. Madhava, and H. M. Walborsky. "A facile intramolecular Michael addition reaction." Journal of Organic Chemistry 51, no. 13 (1986): 2605–7. http://dx.doi.org/10.1021/jo00363a042.

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You, S. L., Q. Cai, and C. Zheng. "Intramolecular Aza-Michael Addition of Indoles." Synfacts 2010, no. 12 (2010): 1428. http://dx.doi.org/10.1055/s-0030-1258922.

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Sánchez-Roselló, María, Carlos del Pozo, and Javier Miró. "Cross-Metathesis/Intramolecular (Hetero-)Michael Addition: A Convenient Sequence for the Generation of Carbo- and Heterocycles." Synthesis 49, no. 13 (2017): 2787–802. http://dx.doi.org/10.1055/s-0036-1589497.

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The high stability and functional group compatibility of ruthenium carbene complexes confer them a great ability to catalyze domino processes. For this reason, the combination of metathesis reactions with additional transformations in a domino fashion has been exploited extensively, with the result of expanding the utility of ruthenium carbene complexes beyond that of just olefin metathesis. Among those domino processes, it is worth mentioning the sequence of cross-metathesis/intramolecular Michael addition, which allows for the generation of a wide variety of carbo- and heterocycles in a very
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Ellis, Graham W. L., C. David Johnson, and David N. Rogers. "Electronic Effects in Intramolecular Michael Addition Reactions." Bulletin des Sociétés Chimiques Belges 91, no. 5 (2010): 437. http://dx.doi.org/10.1002/bscb.19820910596.

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Bates, Roderick W., Weiting Ko, and Viktor Barát. "The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines." Organic & Biomolecular Chemistry 18, no. 5 (2020): 810–29. http://dx.doi.org/10.1039/c9ob02388g.

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Lee, Jusung, Kwang Min Ko, and Sung-Gon Kim. "Asymmetric synthesis of 2,3-disubstituted indolines via an organocatalytic intramolecular Michael addition." RSC Advances 7, no. 89 (2017): 56457–62. http://dx.doi.org/10.1039/c7ra10775g.

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Bhusainahalli, Vedamurthy M., Antonio Rescifina, Nunzio Cardullo, Carmela Spatafora, and Corrado Tringali. "Bio-activated intramolecular anti-aza-Michael addition: stereoselective synthesis of hydantoin derivatives." New Journal of Chemistry 42, no. 22 (2018): 18348–57. http://dx.doi.org/10.1039/c8nj02909a.

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Goud, B. Satish, Kaliyamoorthy Panneerselvam, David E. Zacharias, and Gautam R. Desirajua. "Intramolecular Michael-type addition in the solid state." Journal of the Chemical Society, Perkin Transactions 2, no. 2 (1995): 325. http://dx.doi.org/10.1039/p29950000325.

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Liang, F., Y. Li, X. Bi, and Q. Liu. "Substituted Thiophenes via Intramolecular Thia-anti-Michael Addition." Synfacts 2007, no. 1 (2007): 0031. http://dx.doi.org/10.1055/s-2006-955741.

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Guo, Jiajia, and Shouyun Yu. "Enantioselective synthesis of benzoindolizidine derivatives using chiral phase-transfer catalytic intramolecular domino aza-Michael addition/alkylation." Organic & Biomolecular Chemistry 13, no. 4 (2015): 1179–86. http://dx.doi.org/10.1039/c4ob02227k.

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Dissertations / Theses on the topic "Intramolecular Michael addition"

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Balakrishnan, M. "Synthetic studies towards amaryllidaceae alkaloids: an intramolecular AZA- Michael addition approach." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2695.

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Beck, Daniel Antony Speedie, and beckautomatic@gmail com. "Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses." The Australian National University. Research School of Chemistry, 2006. http://thesis.anu.edu.au./public/adt-ANU20070130.130009.

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Chapter one; “(-)-Rhazinilam and (-)-Rhazinal: Alkaloids with Anti-mitotic Properties Derived from Kopsia teoi”, provides the background information behind the motives that initiated this research project. The plant alkaloid (-)-rhazinilam [(-)-1] and its naturally-occurring derivative (-)-rhazinal [(-)-13] both exhibit potent anti-mitotic activities and, as such, are interesting targets for total synthesis. Chapter one is a review of the literature regarding these two compounds and discusses the occurrence, proposed biosynthetic origins, structural elucidation and biological activites of c
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Beck, Daniel Antony Speedie. "Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses /." View thesis entry in Australian Digital Theses Program, 2006. http://thesis.anu.edu.au/public/adt-ANU20070130.130009/index.html.

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Burns, Alan Richard. "Intramolecular Michael addition approaches to decalatone natural products : The total synthesis of (+)-dictyosphaeric acid A." Thesis, University of York, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535069.

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Belmessieri, Dorine. "Applications of isothioureas in organocatalysis : kinetic resolution of secondary alcohols and intramolecular Michael addition-lactonisation." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4500.

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Obtaining enantiomerically pure compounds is of major importance in modern organic chemistry, and this PhD thesis outlines new advances made in this area. Two new enantioselective synthetic methodologies have been designed using isothiourea based- organocatalysts. A brief introduction to the recent literature involving this catalyst architecture is presented. Then, the results of the structure-activity relationship study carried out on a range of isothiourea catalysts for the kinetic resolution of (±)-1-naphthylethanol 16 is described. Chiral isothiourea HBTM 2.1 58 was identified as the optim
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Cannillo, Alexandre. "Association de la condensation de Petasis à des réactions de cyclisation pour la synthèse de molécules d’intérêt biologique." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112263/document.

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Pour développer de nouveaux outils synthétiques, nous avons élaboré des variantes de la réaction de Petasis. L’utilisation des α-amino aldéhydes dans la réaction de Petasis a permis de synthétiser des diamines chirales avec une diastéréosélectivité totale. La réaction a donnée de bons résultats avec différents groupements protecteurs de l’amine (sulfonamide, carbamate, amide). Cependant au cours de la réaction, les amino aldéhydes s’épimérisent et l’excès énantiomérique des diamines préparées est donc faible (30%). La réaction de Petasis a été associée à la réaction de Diels-Alder dans un proc
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陳恩涵. "Organocatalyzed Intramolecular Michael Addition Reaction." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/37268852645833421689.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>Asymmetric organocatalytic Michael addition has attracted interests due to its environmental friendliness and the generation of multiple stereogenic centers in a single step. In this study‚ treatment of (E)-5-nitro-6-arylhex-5-en-2-one using a catalytic amount of quinine-derived primary amine (20 mol%) and 4-dimethyl aminopyridine (20 mol%) in 1,4-dioxane and DMSO (1:1) at 50 oC to give 3,4-trans- disubstituted cyclohexanones via intramolecular Michael addition process with moderate chemical yields and high-to-excellent stereoselectivities (>95:5 dr and up to 96
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Chen, Li-ju, and 陳俐如. "Total Synthesis of (-)-Allosedridine and (-)-2’-epi-Ethylnorlobelol by Diastereoselective Intramolecular Michael Addition." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/91895770427375037504.

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碩士<br>國立中央大學<br>化學研究所<br>96<br>In this thesis, we apply the chiral methylbenzylamine and their derivatives to control the diastereoselectivity of the methyl 7-chlorohept-2-enoate in intramolecular Michael addition reactions. And we also study the differences of the diastereoselectivity when (R)-α-ethylbenzylamine reacts with different Michael acceptors, including the ester, ketone and Weinreb amide. Finally, we apply this methodology to synthesize two natural products (-)-allosedridine and (-)-2''-epi-ethylnorlobelol.
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Beck, Daniel. "Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses." Phd thesis, 2006. http://hdl.handle.net/1885/46221.

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Chapter one; “(-)-Rhazinilam and (-)-Rhazinal: Alkaloids with Anti-mitotic Properties Derived from Kopsia teoi”, provides the background information behind the motives that initiated this research project. The plant alkaloid (-)-rhazinilam [(-)-1] and its naturally-occurring derivative (-)-rhazinal [(-)-13] both exhibit potent anti-mitotic activities and, as such, are interesting targets for total synthesis. Chapter one is a review of the literature regarding these two compounds and discusses the occurrence, proposed biosynthetic origins, structural elucidation and biological activites of comp
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Book chapters on the topic "Intramolecular Michael addition"

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Araki, S., and T. Hirashita. "Intramolecular Michael Addition." In Science of Synthesis Knowledge Updates KU 2010/4. Georg Thieme Verlag KG, 2010. http://dx.doi.org/10.1055/sos-sd-107-00169.

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Marsden, S. P. "Tandem Michael Addition/Intramolecular Aldol Reaction (Robinson Annulation)." In Ketones. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-026-01026.

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Hof, K., K. M. Lippert, and P. R. Schreiner. "Intramolecular Michael Addition of Nitronates to Conjugated Esters." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00223.

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Takacs, J. M., S. Vayalakkada, and X. Jiang. "Tandem Michael Addition Followed by Intramolecular Addition of Malonate Derivatives to Alkynes." In Compounds with Transition Metal-Carbon pi-Bonds and Compounds of Groups 10-8 (Ni, Pd, Pt, Co, Rh, Ir, Fe, Ru, Os). Georg Thieme Verlag KG, 2001. http://dx.doi.org/10.1055/sos-sd-001-00226.

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Hou, X. L., X. S. Peng, K. S. Yeung, and H. N. C. Wong. "Intramolecular Michael-Type Addition of a 3-Oxa-1,5-enyne." In Fully Unsaturated Small-Ring Heterocycles and Monocyclic Five-Membered Hetarenes with One Heteroatom. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-109-00129.

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Schantl, J. G. "Intramolecular Michael Addition of Hydrazone Followed by [3 + 2] Cycloaddition." In Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00677.

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Taber, Douglass. "Enantioselective Organocatalyzed Construction of Carbocyclic Rings." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0072.

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One of the most practical ways to construct enantiomerically-enriched carbocyclic systems is to effect asymmetric transformation of preformed prochiral rings. Choon-Hong Tan of the National University of Singapore observed (Chem. Commun. 2008, 5526) that allylic halides such as 1 coupled with malonates such as 2 to give the α-methylene ketone 3 in high ee. Xinmiao Liang of the Dalian Institute of Chemical Physics and Jinxing Ye of the East China University of Science and Technology reported (Chem. Commun. 2008, 3302) that nitromethane 5 could be added to enones such as 4 to construct cyclic qu
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Taber, Douglass F. "The Thomson Synthesis of (–)-GB17." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0096.

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(–)-GB17 3 is one of the Galbulimima alkaloids, a family that shows a wide range of interesting physiological activity. Regan J. Thomson of Northwestern University devised (Angew. Chem. Int. Ed. 2012, 51, 2481) a convergent assembly of 3, a key step of which was the intramolecular Michael cyclization of 1 to 2. The hydroxy aldehyde 6 was prepared by alkylation of the dithiane 4 with 5, followed by hydrolysis. The preparation of 9, by condensation of 8 with 7 followed by hydrogenation and protection, had been reported by Lhommet. Condensation of 9 with the linchpin reagent 10 gave an intermedia
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Taber, Douglass. "The Carter Synthesis of (-)-Lycopodine." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0099.

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Rich G. Carter of Oregon State University described (J. Am. Chem. Soc. 2008, 130, 9238) the first enantioselective synthesis of the Lycopodium alkaloid (-)-lyopodine 3. A key step in the assembly of 3 was the diastereoselective intramolecular Michael addition of the keto sulfone of 1 to the enone, leading to the cyclohexanone 2. The key cyclization substrate 1 bore a single secondary methyl group. While that could have been derived from a natural product, it was operationally easier to effect chiral auxiliary controlled conjugate addition to the crotonyl amide 4, leading, after methoxide excha
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Taber, Douglass F. "Alkaloid Synthesis: (–)-α-Kainic Acid (Cohen), Hyacinthacine A2 (Fox), (–)-Agelastatin A (Hamada), (+)-Luciduline (Barbe), (+)-Lunarine (Fan), (–)-Runanine (Herzon)." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0058.

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The intramolecular ene cyclization is still little used in organic synthesis. Theodore Cohen of the University of Pittsburgh trapped (J. Org. Chem. 2011, 76, 7912) the cyclization product from 1 with iodine to give 2, setting the stage for an enantiospecific total synthesis of (–)-α-kainic acid 3. Intramolecular alkene hydroamination has been effected with transition metal catalysts. Joseph M. Fox of the University of Delaware isomerized (Chem. Sci. 2011, 2, 2162) 4 to the trans cyclooctene 5 with high diastereocontrol. Deprotection of the amine led to spontaneous cyclization, again with high
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Conference papers on the topic "Intramolecular Michael addition"

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Ferreira*, Misael, and Marcus Mandolesi Sá. "Intramolecular Aza-Anti-Michael Addition for the Synthesis of 2-Iminothiazolidines." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013819173959.

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