Relevant bibliographies by topics / Intranasal administration of dopamine

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Intranasal administration of dopamine'

Author: Grafiati
Published: 5 June 2025
Last updated: 16 July 2025

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Journal articles on the topic "Intranasal administration of dopamine"

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Dagda, Ruben K., Raul Y. Dagda, Emmanuel Vazquez-Mayorga, Bridget Martinez, and Aine Gallahue. "Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats." International Journal of Molecular Sciences 24, no. 1 (2022): 690. http://dx.doi.org/10.3390/ijms24010690.

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Parkinson’s Disease (PD) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. Current standard-of-care includes oral administration of Levodopa to address motor symptoms, but this treatment is not disease-modifying. A reduction in Protein Kinase A (PKA) signaling and neurotrophic support contributes to PD pathology. We previously showed that enhancing PKA activity in the brain via intraperitoneal administration of Forskolin in Parkinsonian rats (PINK1 knockout) abrogate motor symptoms and loss of midbrain dopamine neurons. Given that intraperitonea
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Nedorubov, Andrey Anatolievich, Alexey Nikitich Pavlov, Natalia Valeryevna Pyatigorskaya, Galina Eduardovna Brkich, and Marina Maksimovna Shabalina. "Pharmacokinetics of Nanosomal Form of Levodopa in Intranasal Administration." Open Access Macedonian Journal of Medical Sciences 7, no. 21 (2019): 3509–13. http://dx.doi.org/10.3889/oamjms.2019.749.

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BACKGROUND: Parkinson's disease is one of the most common neurological diseases. Pathogenesis of the disease is associated with destruction and death of neurons that produce the neurotransmitter dopamine. The precursor to dopamine, which crosses the protective blood-brain barrier, is the amino acid 3, 4-dihydroxy-L-phenylalanine – levodopa, L-DOPA. The investigational drug is a pharmaceutical composition, containing L-DOPA as an active substance, which is distributed in a polymer matrix based on a biodegradable copolymer of lactic/glycolic acids.
 AIM: This work aimed to study the main ph
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Amikishieva, A., and A. Cholodar. "P.1.c.066 Behavioural effects of intranasal dopamine administration." European Neuropsychopharmacology 20 (August 2010): S273. http://dx.doi.org/10.1016/s0924-977x(10)70353-9.

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Cox, Sylvia M. L., Chawki Benkelfat, Alain Dagher, et al. "Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans." Biological Psychiatry 65, no. 10 (2009): 846–50. http://dx.doi.org/10.1016/j.biopsych.2009.01.021.

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Levicheva, N. O., O. G. Berchenko, and Y. Y. Ilina. "Effect of Intranasal Administration of Dopamine on Odor Perception in Rats with Nigrostriatal Dysfunction." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 3 (2021): 333–39. http://dx.doi.org/10.26693/jmbs06.03.333.

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In recent years, there has been a growing interest in finding early predictors of Parkinson’s disease. In this regard, it is worth noting the olfactory dysfunction, which is associated with the death of neurons in the structures of the limbic system of the brain and a decrease in dopamine levels in the striatum. It was found that most patients with Parkinson’s disease have a clear olfactory dysfunction in the form of impaired differentiation and identification of odors. It has been suggested that the use of low doses of dopamine in the early stages of Parkinson’s disease will stop the progress
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Mizutani, Asuka, Masato Kobayashi, Makoto Ohuchi, et al. "Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood–Brain Barrier Permeability in Mice." Pharmaceutics 14, no. 5 (2022): 1026. http://dx.doi.org/10.3390/pharmaceutics14051026.

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Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was examined using domperidone, a dopamine D2 receptor ligand, as the model drug, with intranasal administration at 0, 15, or 30 min before intravenous [123I]IBZM administration. In the striatum, [123I]IBZM accumulation was significantly lower after intranasal (IN) domperidone administration than in contr
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Sergeyeva, T. N., and K. S. Sergeyeva. "EFFECTS OF INTRANASAL BACTERIAL ENDOTOXIN ADMINISTRATION ON EXPRESSION OF ALPHA-SYNUCLEIN IN PERIPHERAL STRUCTURES OF THE OLFACTORY SYSTEM." Medical academic journal 19, no. 1S (2019): 103–4. http://dx.doi.org/10.17816/maj191s1103-104.

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The involvement of olfactory dysfunction led to the proposal of ‘the olfactory vector hypothesis’ to explain both olfactory losses and the etiology of idiopathic Parkinson disease (PD) as a result of the transit of an environmental virus or chemical agent that enters the central nervous system (CNS) via the nose, activating the glial response of the brain that may lead to dopamine neuronal damage. Previously created chronic, progressive a mouse model of PD by intranasal instillation of a LPS displayed several key features of early-stage PD: a progressive hypokinesia, selective loss of dopamine
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Geiko, Valentina, and Olga Berchenko. "Correction of the wake-sleep cycle by intranasal administration of dopamine in modeling of the preclinical stage of Parkinson's disease in rats." EUREKA: Life Sciences, no. 5 (November 16, 2022): 47–57. https://doi.org/10.21303/2504-5695.2022.002643.

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Sleep disorders, which are among the earliest and most sensitive non-motor manifestations of Parkinson's disease (PD), are not diagnosed in 40–50 % of patients and are not subject to the necessary correction. In this regard, the ineffectiveness of a late start of treatment, when more than 50 % of dopamine-producing neurons are already affected, dictates the need to search for and develop approaches to the prevention and slowdown of neurodegenerative pathology at the preclinical stages of its development using adequate experimental models. Taking into account the low bioavailability of dopamine
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Geiko, Valentina, and Olga Berchenko. "Correction of the wake-sleep cycle by intranasal administration of dopamine in modeling of the preclinical stage of Parkinson's disease in rats." EUREKA: Life Sciences, no. 5 (November 16, 2022): 47–57. http://dx.doi.org/10.21303/2504-5695.2022.002643.

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Sleep disorders, which are among the earliest and most sensitive non-motor manifestations of Parkinson's disease (PD), are not diagnosed in 40–50 % of patients and are not subject to the necessary correction. In this regard, the ineffectiveness of a late start of treatment, when more than 50 % of dopamine-producing neurons are already affected, dictates the need to search for and develop approaches to the prevention and slowdown of neurodegenerative pathology at the preclinical stages of its development using adequate experimental models. Taking into account the low bioavailability of dopamine
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Lao, Chu Lan, Yen-Hsi Kuo, Yueh-Ting Hsieh, and Jin-Chung Chen. "Intranasal and Subcutaneous Administration of Dopamine D3 Receptor Agonists Functionally Restores Nigrostriatal Dopamine in MPTP-Treated Mice." Neurotoxicity Research 24, no. 4 (2013): 523–31. http://dx.doi.org/10.1007/s12640-013-9408-1.

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Dissertations / Theses on the topic "Intranasal administration of dopamine"

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Jansson, Björn. "Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905.

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<p>The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer.</p><p>In a mouse model, [<sup>3</sup>H]-dopamine was given as a unilateral nasal dose. The resulting radioactivity in the ipsilateral olfactory bulb was significantly higher than that in the contralateral bulb and peaked at 4 h. Tape section autoradiogra
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Charlton, Stuart Thomas. "Drug delivery to the brain via intranasal administration." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275962.

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Metzler, Barbara. "Downregulation of systemic immune responses by oral and intranasal antigen administration." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/270425.

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Bernocchi, Beatrice. "Porous maltodextrin nanoparticles for the intranasal delivery of vaccines." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S010/document.

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Au cours des dernières décennies, la technologie des nanoparticules pour la délivrance des vaccins au niveau de muqueuses a reçu un intérêt croissant. L’administration intranasale possède de grands avantages pour la stimulation du système immunitaire, telles que la stimulation d’une immunité protectrice locale et systémique. Cependant des systèmes de délivrance et des adjuvants sont souvent nécessaires pour déclencher efficacement la réponse immunitaire. Nous avons appliqué la technologie des nanoparticules en tant que système de délivrance d'un vaccin universel nasal contre la grippe dans un
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Pinheiro, Sabrina dos Santos. "Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/158232.

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Objetivos: Verificar eficácia da cetamina intranasal na sedação de crianças para punção venosa. Métodos: Estudo randomizado, duplo-cego, placebo controlado realizado no Hospital de Clínicas de Porto Alegre entre janeiro e agosto de 2016. Estudo aprovado pela comissão de ética em pesquisa da instituição. Incluídas crianças que necessitasse de punção venosa, sendo randomizadas a receber cetamina IN 4mg/Kg ou solução fisiológica no grupo Placebo. Os grupos foram comparados quanto: tempo de punção, facilidade do Enfermeiro para realizar o procedimento, eventos adversos, alterações dos sinais vitai
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Korhonen, Jessica, Modin Håkan, and Alexander Jönsson. "Effekter av intranasalt Fentanyl i prehospital akutsjukvård." Thesis, Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-24398.

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Akut smärta är det vanligast förekommande symtom som den prehospitala akutsjukvården ställs inför. Behandlingsriktlinjerna presenterar intranasalt Fentanyl som ett alternativ för akut smärtlindring. Då det finns ett begränsat utbud av studier utförda på vuxna och inom prehospital akutsjukvård var syftet med studien att beskriva effekter av intranasal administrering av Fentanyl i prehospital akutsjukvård. Studien genomfördes med en kvantitativ metod och med en retrospektiv, deskriptiv design. Studien baserades på en granskning av 15 patientjournaler från Ambulanssjukvården i Region Halland och
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Skragge, Michael. "Absorption predicts mysticism and spirituality, but not following intranasal oxytocin administration : A sensory deprivation experiment." Thesis, Stockholms universitet, Psykologiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-149613.

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Recent research has indicated a causal link between oxytocin and spirituality. The present experiment sought to examine the effects of intranasal oxytocin (IN-OT) and absorption on mysticism and spirituality in a sensory deprivation setting. The results failed to find any main effects of IN-OT on mysticism, or on spirituality. Interaction effects were discovered however, where IN-OT interacted with absorption both on mysticism and spirituality. More specifically IN-OT undermined the association between absorption and outcomes that were observed in the placebo control condition. The results con
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Filho, Eduardo Mekitarian. "Utilização do midazolam intranasal como sedativo para tomografia em crianças." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/.

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Objetivos: Avaliar a segurança e a eficácia do midazolam intranasal (MIN) para sedação para tomografia em crianças, bem como a qualidade dos estudos radiológicos obtidos com esta técnica. Material e métodos: Entre dezembro de 2011 e julho de 2012, este estudo prospectivo avaliou o MIN como sedativo para crianças submetidas à tomografia sem acesso venoso. Após aprovação do Comitê de Ética em Pesquisa e consentimento dos responsáveis, 0,4 mg/kg de MIN foi administrado, sendo feita dose adicional de 0,1 mg/kg se o nível de sedação avaliado pela Escala de Sedação de Ramsay não fosse atingida após
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Thienel-Holzmann, Matthias [Verfasser], and Manfred [Akademischer Betreuer] Hallschmid. "Improving metabolic control in humans by intranasal neuropeptide administration / Matthias Günter Thienel-Holzmann ; Betreuer: Manfred Hallschmid." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199546240/34.

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Zanellato, Fabbri Natalia 1981. "Utilização da provocação nasal com histamina e avaliação rinomanometrica em estudos de bioequivalencia para sprays nasais." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311768.

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Orientador: Ricardo de Lima Zollner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-14T06:15:03Z (GMT). No. of bitstreams: 1 ZanellatoFabbri_Natalia_M.pdf: 1108663 bytes, checksum: 3362aa87243ab7742f6bb55df1f964e6 (MD5) Previous issue date: 2009<br>Resumo: Rinite alérgica é uma doença comum com ampla morbidade, que gera aumento considerável nos custos de tratamento médico, redução da produtividade no trabalho e absenteísmo escolar. A aplicação tópica de corticosteróides intranasal é amplamente reconhecida com
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Books on the topic "Intranasal administration of dopamine"

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1938-, Chien Yie W., ed. Transnasal systemic medications: Fundamentals, developmental concepts, and biomedical assessments. Elsevier, 1985.

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Dominique, Duchêne, Association de pharmacie galénique industrielle., and Swedish Academy of Pharmaceutical Sciences., eds. Buccal and nasal administration as an alternative to parenteral administration: European symposium, Paris, 10 and 11 December 1991. Editions de Santé., 1992.

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A, Obeso J., and Olanow C. W. 1941-, eds. Beyond the decade of the brain. Wells Medical, 1997.

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David, Ganderton, Jones T. M. 1942-, Pharmaceutical Society of Great Britain., and King's College (University of London). Chelsea Dept. of Pharmacy., eds. Drug delivery to the respiratory tract. VCH, 1987.

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Mamo, David C. The effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine. National Library of Canada, 2003.

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A, Obeso J., Horowski R. 1944-, and Marsden C. David, eds. Continuous dopaminergic stimulation in Parkinson's disease: Proceedings of the workshop in Alicante, Spain, September 22-24, 1986. Springer-Verlag, 1988.

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Ritual enemas and snuffs in the Americas. Centre for Latin American Research and Documentation, 1985.

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Lameire, Norbert. Prevention of acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0226_update_001.

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This chapter summarizes the pharmacological interventions that can be used in the prevention of acute kidney injury (AKI). These following interventions are discussed: the use and selection of vasopressors; the administration of loop diuretics and mannitol; vasodilating drugs including dopamine, atrial natriuretic peptide, nesiritide, fenoldopam, and adenosine antagonists. The role of N-acetylcysteine in the prevention of contrast-induced AKI and cardiac surgery is discussed. The chapter concludes with a summary of the potential role of insulin-like growth factor and erythropoietin in the prev
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Thien Lim, Thien, and Hubert H. Fernandez. Parkinson Disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0003.

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Levodopa is the most efficacious medication to reduce motor impairment in Parkinson disease (PD). The effect of levodopa can wear off after time, which is treated by increasing the dose or shortening the inter-dose interval. Dyskinesias can be treated by a change in levodopa dosing or route of administration, such as by constant administration of levodopa as a gel through a jejunostomy tube or a change to dopamine agonists or amantadine. Non-motor signs including depression can be treated with several antidepressants. Surgical treatments including pallidotomy, thalamotomy, and deep brain stimu
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Book chapters on the topic "Intranasal administration of dopamine"

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Olsson, P., F. Kuylenstierna, C.-J. Johansson, PO Gunnarsson, and M. Bende. "Pharmacokinetics of Nicotine after Intranasal Administration." In Effects of Nicotine on Biological Systems. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7457-1_8.

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Harris, A. S. "Biopharmaceutical Aspects on the Intranasal Administration of Peptides." In Delivery Systems for Peptide Drugs. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9960-6_15.

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Evgen’ev, Michael B., David G. Garbuz, Alexei V. Morozov, and Natalia V. Bobkova. "Intranasal Administration of Hsp70: Molecular and Therapeutic Consequences." In HSP70 in Human Diseases and Disorders. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89551-2_16.

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Greenshaw, Andrew J., Glen B. Baker, and Thomas B. Wishart. "Dopamine Receptor Changes During Chronic Drug Administration." In Psychoactive Drugs. Humana Press, 1989. http://dx.doi.org/10.1007/978-1-59259-464-1_7.

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Corrigall, William A. "Regulation of Intravenous Nicotine Self-Administration — Dopamine Mechanisms." In Effects of Nicotine on Biological Systems. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7457-1_56.

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Kalivas, P. W. "Repeated Administration with Enkephalin into the A-10 Dopamine Region Produces Supersensitivity of the Mesolimbic Dopamine System." In Dopaminergic Systems and their Regulation. Palgrave Macmillan UK, 1986. http://dx.doi.org/10.1007/978-1-349-07431-0_59.

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Zahniser, Nancy R., Joanna Peris, Pamela Curella, Linda P. Dwoskin, Laurie O’Keefe, and Sally J. Boyson. "Repeated Cocaine Administration Results in Supersensitive Nigrostriatal D-2 Dopamine Autoreceptors." In Pharmacology and Functional Regulation of Dopaminergic Neurons. Palgrave Macmillan UK, 1988. http://dx.doi.org/10.1007/978-1-349-10047-7_26.

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Kulkarni, Amod P., Dhirendra Govender, Lauriston A. Kellaway, and Girish J. Kotwal. "Central Nervous System Distribution of the Poxviral Proteins After Intranasal Administration of Proteins and Titering of Vaccinia Virus in the Brain After Intracranial Administration." In Methods in Molecular Biology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-876-4_18.

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Christensen, A. V., J. Arnt, and O. Svendsen. "Pharmacological Differentiation of Dopamine D-1 and D-2 Antagonists After Single and Repeated Administration." In Dyskinesia. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70140-5_22.

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Dostert, Philippe, Didier Deffond, Renata La Croix, Didier Vernay, Margherita Strolin Benedetti, and Gerard Dordain. "Effect of Selegiline Administration on the Urinary Excretion of Dopamine-Derived Tetrahydroisoquinoline Alkaloids in Parkinson’s Disease Patients." In Alzheimer’s and Parkinson’s Diseases. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4757-9145-7_81.

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Conference papers on the topic "Intranasal administration of dopamine"

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Yu-Taeger, Libo, Janice Stricker-Shaver, Katrin Arnold, et al. "I22 Intranasal administration of mesenchymal stem cells ameliorates the abnormal dopamine transmission system and inflammatory reaction in the R6/2 mouse model of huntington disease." In EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/jnnp-2018-ehdn.258.

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Kulkarni, Tanmay, Deepa Gupta, Dan Covey, Joseph Cheer, and Gymama Slaughter. "Dopamine sensing upon amphetamine administration." In 2015 IEEE Sensors. IEEE, 2015. http://dx.doi.org/10.1109/icsens.2015.7370580.

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Litvinova, M., E. Bychkov, A. Lebedev, Petr Shabanov, and N. Arseniev. "Estimation of behavioral responses with intranasal administration of 6-OHDA." In II Международная конференция, посвящеенная 100- летию И.А. Држевецкой. СКФУ, 2022. http://dx.doi.org/10.38006/9612-62-6.2022.196.198.

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Lethagen, S., A. S. Harris, and I. M. Nilsson. "A NEW DELIVERY SYSTEM FOR DDAVP: CLINICAL EXPERIENCE OF DDAVP SPRAY PUMP IN MILD HAEMOPHILIA A AND vWD TYPE I." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644704.

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Until recently, the reliability and predectibility of the intranasal route of administration of DDAVP has been too poor to recommend it in routine practice.With the development of a new delivery system in the form of a spray puip we have previously shown that absorption and biological effect of DDAVP in volunteers is enhanced(1).In this patient study we conpared intranasal administration of 300 pg DDAVP using a newly developed pre-corrpression spray pinp with intravenous administration of 0.3 - 0.4 pg/kg. We studied 24 patients with mild haemophilia A, 23 with mild vWD Type IA and 8 with Type
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Lethagen, S., A. S. Harris, and I. M. Nilsson. "COMPARISON OF TO BIOLOGICAL EFFECT, PHARMACOKINETICS AND REPRODUCIBILITY OF INTRANASAL AND INTRAVENOUS ADMINISTRATION OF DDAVP." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644705.

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DDAVP has previously mostly been given by the parenteral route but the development of intranasal delivery has made it possible for the patients to treat themselves at home without delay. The effect of intranasal administration of DDAVP as drops using a rhinyle catheter or a pipette has been unpredictable. The development of a spray has improved the intranasal administration of DDAVP with well controlled doses and better absorption.In this study we conpared intranasal administration of 300 pg DDAVP by spray, with intravenous administration of 0.2, 0.3 and 0.4 pg DDAVP/kg in 10 healthy volunteer
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Sohn, Jung Ho, Joo Young Kim, yong won Lee, Jae Hyun Lee, and Jung Won Park. "Intranasal Administration Of Unmethylated CpG-Oligodeoxynucleotide Attenuates Cockroach Extract-induced Pulmonary Inflammation." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5763.

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Rautiola, Davin, and Ronald A. Siegel. "Nasal Spray Device for Administration of Two-Part Drug Formulations." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3216.

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Intranasal drug delivery is an attractive route to noninvasively achieve a rapid therapeutic effect, avoid first pass metabolism, and bypass the blood brain barrier. However, the types of drugs that can be administered by this route has been limited, in part, by device technology. Herein, we describe a pneumatic nasal spray device that is capable of mixing liquid and solid components of a drug formulation as part of the actuation process during dose administration. The ability to store a nasal spray drug formulation as two separate components can be leveraged to solve a variety of stability is
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Fatianova, Alina, Valentina Lavrinenko, and Tatiana Kurliandchik. "NEUROHYPOPHYSIAL VASOPRESSIN HYDROOSMOTIC EFFECT REALIZATION IN THE RAT KIDNEY UNDER DOPAMINE ADMINISTRATION." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2363.sudak.ns2021-17/383.

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Sidorov, Nikita Gennadievich, Natalia Alexandrovna Mikhailova, and Vladimir Vladimirovich Gureev. "STUDY OF THE ACUTE TOXICITY OF A NASAL SPRAY BASED ON ANTIGENS OF OPPORTUNISTIC BACTERIA." In Themed collection of papers from Foreign international scientific conference «Joint innovation - joint development». by HNRI «National development» in cooperation with PS of UA. February 2025. - Harbin (China). Crossref, 2025. https://doi.org/10.37539/250227.2025.63.15.011.

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The article presents the results of determining the acute toxicity of a nasal spray based on antigens of opportunistic bacteria in two formulations: with and without a prolonging agent. According to the Hodge and Sterner toxicity classification, when administered to mice at the maximum possible doses, the formulations were classified as up to class 4 toxicity for subcutaneous administration and up to class 3 toxicity for intranasal administration. These findings support the feasibility of further development of the formulations.
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Quispe, Rodrigo, Jorge A. Trevino, Faizan Khan, and Vera Novak. "Strategies for nose-to-brain drug delivery." In the 8th International Workshop on Innovative Simulation for Healthcare. CAL-TEK srl, 2019. http://dx.doi.org/10.46354/i3m.2019.iwish.017.

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"Intranasal drug administration is an effective method that has shown promise for delivering drugs directly to the brain. This approach is associated with many challenges, and efficacy in bypassing blood-brain barrier (BBB) is debated. This review describes the pathways of nose-to-brain drug delivery, physicochemical drug properties that influence drug uptake through the nasal epithelium, physiological barriers, methods to enhance nose-to-brain absorption, drug bioavailability and biodistribution, and intranasal devices for nose-to-brain drug delivery. The mechanism of each device is described
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Reports on the topic "Intranasal administration of dopamine"

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Chen, Qi, Ryan Vander Veen, Darin M. Madson, and D. L. Hank Harris. Immunization for Influenza A Virus by Intranasal Administration of Alphavirus Replicon Particles. Iowa State University, 2013. http://dx.doi.org/10.31274/ans_air-180814-29.

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Singh, Ruchi, Akhiya Nail, and Nirendra Kumar Rai. Effectiveness of Vitamin B12 Supplementation on cognitive, motor & mood instability of Parkinson’s disease patients on levodopa treatment :A Systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0066.

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Review question / Objective: The treatment of choice for patients of Parkinson's disease is levodopa. However, levodopa has been suggested to decrease Vit B12 level in these patients. Thus, the research question for this systematic review is whether vit B 12 supplementation in Parkinson's disease(PD) patients on treatment with levodopa improves vit B12 level effecting the Cognition, Motor functions and Mood instability among them in comparison to PD patients on levodopa treatment who are not supplemented with Vit B12. Condition being studied: Parkinson disease is the progressive degeneration o
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99mTc SPECT-CT, Consensus QIBA Profile. Chair Yuni Dewaraja and Robert Miyaoka. Radiological Society of North America (RSNA)/Quantitative Imaging Biomarkers Alliance (QIBA), 2019. https://doi.org/10.1148/qiba/20191021.

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The quantification of 99mTc labeled biomarkers can add unique value in many different settings, ranging from clinical trials of investigation new drugs to the treatment of individual patients with marketed therapeutics. For example, goals of precision medicine include using companion radiopharmaceutical diagnostics as just-in-time, predictive biomarkers for selecting patients to receive targeted treatments, customizing doses of internally administered radiotherapeutics, and assessing responses to treatment. This Profile describes quantitative outcome measures that represent proxies of target c
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Oxytocin Administration, Neural Sensitivity, and Autism. ACAMH, 2023. http://dx.doi.org/10.13056/acamh.24918.

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In this Papers Podcast, Dr. Mattijis Moerkerke discusses his JCPP paper 'Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial'. Mattijis is the first author of the paper.
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