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Relevant bibliographies by topics / Intrathecal injection

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Academic literature on the topic 'Intrathecal injection'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Intrathecal injection"

1

Jhamandas, K., M. Sutak, and S. Lemaire. "Comparative spinal analgesic action of dynorphin1-8, dynorphin1-13, and a kappa-receptor agonist U50,488." Canadian Journal of Physiology and Pharmacology 64, no. 3 (1986): 263–68. http://dx.doi.org/10.1139/y86-042.

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The effect of intrathecal injections of dynorphin1-8 (DYN1-8), dynorphin1-13 (DYN1-13), and a putative kappa agonist, U50,488 was tested in the rat tail-flick test. DYN1-8 and DYN1-13 (5, 10, 20 μg) produced a dose-related biphasic antinociceptive response consisting of an initial and a delayed response. Injection of U50,488 (20, 40 60 μg) produced a monophasic response. The antinociceptive effect of DYN1-8 (5, 10, 20 μg) and DYN1-3 (20 μg), but not U50,488 (20 μg), was present 24 h postintrathecal injection. Pretreatment with systemic naloxone (2 mg/kg s.c.) attenuated the delayed response, b

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Cunicelli, Marco, Elizabeth Piwowarski, and Tejal Raju. "A Case of Priapism After Intrathecal Morphine Injection." Pain Medicine Case Reports 5, no. 5 (2021): 273–75. http://dx.doi.org/10.36076/pmcr.2021.5.273.

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BACKGROUND: Data on the frequency of priapism after spinal injections is lacking. Priapism may occur as a rare complication following intrathecal narcotic administration. This report describes an uncommon adverse reaction to intrathecal morphine injection uniquely without concurrent local anesthetic. CASE REPORT: A 74-year-old male presented to the pain management office for a scheduled intrathecal bolus trial to monitor for response prior to permanent placement of an intrathecal pump. Following an intrathecal injection of a bolus dose of 100 mcg of morphine, the patient noted the development

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Kim, Yeo Ok, Ji A. Song, Woong Mo Kim, and Myung Ha Yoon. "Antiallodynic Effect of Intrathecal Korean Red Ginseng in Cisplatin-Induced Neuropathic Pain Rats." Pharmacology 105, no. 3-4 (2019): 173–80. http://dx.doi.org/10.1159/000503259.

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Background: Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryptamine (5-HT)7 receptor at the spinal level. Methods: CINP was evoked by intraperitoneal injection of cisplatin in male Sprague-Dawley rats. After examining the effects of intrathecally administered KRG on CINP, 5-HT receptor antagonist (dihydroergocristine [DHE]) was pretreated

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Pan, Hui-Lin, Shao-Rui Chen, and James C. Eisenach. "Role of Spinal NO in Antiallodynic Effect of Intrathecal Clonidine in Neuropathic Rats." Anesthesiology 89, no. 6 (1998): 1518–23. http://dx.doi.org/10.1097/00000542-199812000-00031.

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Background The role of spinal nitric oxide (NO) in neuropathic pain remains uncertain. Although intrathecal clonidine causes NO release in the spinal cord, the functional role of spinal NO in clonidine-produced analgesia has not been examined. The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine. Methods Allodynia was produced in rats by tight ligation of the left L5-L6 spinal nerves. Intrathecal catheters were inserted with tips in the lumbar intrathecal space.

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Li, Gehui, Hao Wang, Xiaofei Qi, Xiaolei Huang, and Yuantao Li. "Intrathecal dexmedetomidine improves epidural labor analgesia effects: a randomized controlled trial." Journal of International Medical Research 49, no. 4 (2021): 030006052199953. http://dx.doi.org/10.1177/0300060521999534.

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Objective α2‑agonists and opioids have been used as intrathecal adjuvants to local anesthetics for several years, but the effect of intrathecal dexmedetomidine (Dex) or sufentanil combined with epidural ropivacaine in labor analgesia is not fully understood. Methods A total of 108 parturient women receiving combined spinal-epidural labor analgesia were randomly divided into three groups. Group C received l mL saline (0.9%) intrathecally, Group D received 5 µg Dex intrathecally, and Group S received 5 µg sufentanil intrathecally. All parturient women then received 0.1% epidural ropivacaine and

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Ouyang, Handong, Peizong Wang, Wan Huang, Qiang Li, Bilin Nie, and Weian Zeng. "Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test." Pain Research and Management 20, no. 6 (2015): 321–26. http://dx.doi.org/10.1155/2015/902914.

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BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding and function, acting via the allosteric site on the α2A-adrenergic receptor.OBJECTIVES: To investigate the antinociceptive interaction of intrathecal amiloride and the α2-adrenoceptor agonist tizanidine using a rat formalin test.METHODS: Sprague-Dawley rats were chronically implanted with lumbar intra

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Pan, Hui-Lin, Shao-Rui Chen, and James C. Eisenach. "Intrathecal Clonidine Alleviates Allodynia in Neuropathic Rats." Anesthesiology 90, no. 2 (1999): 509–14. http://dx.doi.org/10.1097/00000542-199902000-00027.

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Background Intrathecally administered clonidine increases release of spinal acetylcholine, which may be related to its analgesic action in neuropathic pain. The current study determined the role of spinal muscarinic and nicotinic receptors in the antiallodynic effect of intrathecally administered clonidine in spinal nerve-ligated rats. Methods Allodynia was produced in rats by ligation of the left L5-L6 spinal nerves. Mechanical allodynia was determined by application of von Frey filaments to the left hindpaw. The effect of intrathecal injection of saline, two muscarinic receptor antagonists (

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Guo, Tian-Zhi, Jian-Yu Jiang, Ann E. Buttermann, and Mervyn Maze. "Dexmedetomidine Injection into the Locus Ceruleus Produces Antinociception." Anesthesiology 84, no. 4 (1996): 873–81. http://dx.doi.org/10.1097/00000542-199604000-00015.

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Background Alpha(2)-Adrenergic agonists such as clonidine and dexmedetomidine are known to produce sedation and analgesia in humans. The sedative effect of these agents is thought to occur through supraspinal pathways, involving the locus ceruleus (LC) and its projections in rats. While the antinociceptive response to alpha(2) agonists, given intrathecally, is mediated predominantly in the spinal cord, other sites of action have not been systematically studied. The authors examined whether alpha(2)-adrenergic receptors in the LC mediate an antinociceptive effect. Methods For administration of

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Zada, Gabriel, and Thomas C. Chen. "A Novel Method for Administering Intrathecal Chemotherapy in Patients With Leptomeningeal Metastases and Shunted Hydrocephalus: Case Report." Operative Neurosurgery 67, no. 3 (2010): ons. http://dx.doi.org/10.1227/01.neu.0000383138.78632.ba.

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Abstract BACKGROUND AND IMPORTANCE: Leptomeningeal metastatic disease occurs in a minority of patients with systemic neoplastic disease. Before the initiation of intrathecal chemotherapy, hydrocephalus must be addressed with a cerebrospinal fluid (CSF)-diverting shunt. CSF diversion can theoretically prematurely divert chemotherapeutic drugs that are administered intrathecally, thereby potentially reducing the efficacy of such treatments. CLINICAL PRESENTATION: We report on a patient with leptomeningeal disease and hydrocephalus secondary to metastatic bladder carcinoma requiring insertion of

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Copp, Steven W., Audrey J. Stone, Katsuya Yamauchi та Marc P. Kaufman. "Effects of peripheral and spinal κ-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, № 3 (2014): R281—R289. http://dx.doi.org/10.1152/ajpregu.00156.2014.

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The exercise pressor reflex is greater in rats with ligated femoral arteries than it is in rats with freely perfused femoral arteries. The exaggerated reflex in rats with ligated arteries is attenuated by stimulation of μ-opioid and δ-opioid receptors on the peripheral endings of thin-fiber muscle afferents. The effect of stimulation of κ-opioid receptors on the exercise pressor reflex is unknown. We tested the hypothesis that stimulation of κ-opioid receptors attenuates the exercise pressor reflex in rats with ligated, but not freely perfused, femoral arteries. The pressor responses to static

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Dissertations / Theses on the topic "Intrathecal injection"

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DUALE, CHRISTIAN JEAN. "Effets analgesiques du midazolam intrathecal : etude experimentale chez le rat." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13829.

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Machino, Masaaki, Yasutsugu Yukawa, Tetsuro Hida, et al. "A Prospective Randomized Study for Postoperative Pain Relief of Lower Extremity Fractures: Efficacy of Intrathecal Morphine Administration." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/14176.

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Moroto, Denise. "A dexametasona administrada pela via subaracnoidea é toxica à medula espinal e meninges de coelhos?" Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153620.

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Ratzlaff, Viviane. "Padronização e validação de um novo modelo de febre induzida pela injeção intratecal de prostaglandina e2 em ratos jovens." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11148.

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The fever response, besides being part of host defense response to infection or inflammation, is associated with discomfort and anxiety and may constitute a risk for febrile seizures in children. Therefore, antipyretic therapy is routinely prescribed for febrile patients. The animal models of fever using the systemic injection of lipopolysaccharide (LPS) and Baker yeast, described in the literature, are suitable for screening of novel antipyretics, but they do not provide information regarding the mechanism of action of these compounds. Therefore, the present study aimed to describe and valida

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Rane, Lindgren Kerstin. "Intrathecal adenosine for treatment of acute pain : safety assessments and evaluation in experimental, surgical and labour pain /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-750-9.

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Maher, Sue Ellen. "A study of the antinociceptive and toxicological effects of intrathecal dexmedetomidine and methoxamine in the rat." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/MQ34204.pdf.

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Charpentier, Éric. "Acropathie ulcero-mutilante par arachnoidite de la queue de cheval apres injections intrathecales d'hydrocortisone : a propos d'une observation." Nancy 1, 1991. http://www.theses.fr/1991NAN11105.

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Lionnet, Ludivine. "Administration d'Eugénol intrathécal pour le traitement de la douleur neuropathique." Thèse, 2009. http://hdl.handle.net/1866/3724.

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Le projet porte sur l’étude de l’effet de l’eugénol, composant principal du clou de girofle, sur la douleur neuropathique. L’objectif principal du projet était de déterminer la contribution du système nerveux central dans l’effet analgésique de l’eugénol. Lors d’une étude préliminaire, la pénétrabilité de l’eugénol a été évaluée dans le système nerveux central du rat. Des échantillons de sang, de cerveau et de moelle épinière ont été prélevés et les concentrations d’eugénol dans ces différents tissus ont été analysées à l’aide d’un spectromètre de masse. Les résultats ont montré que l’eugénol

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Books on the topic "Intrathecal injection"

1

Gianino, Janet M. Intrathecal drug therapy for spasticity and pain: Practical patient management. Springer, 1996.

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McClenahan, Maureen F., and William Beckman. Pain Management Techniques. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190217518.003.0011.

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This chapter provides a broad review of various interventional pain management procedures with a focus on indications, anatomy, and complications. Specific techniques reviewed include transforaminal epidural steroid injection, lumbar sympathetic block, stellate ganglion block, cervical and lumbar radiofrequency ablation, gasserian ganglion block, sacroiliac joint injection, celiac plexus block, lateral femoral cutaneous nerve block, ilioinguinal block, lumbar medial branch block, obturator nerve block, ankle block, occipital nerve block, superior hypogastric plexus block, spinal cord stimulati

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Paech, Michael J., and Patchareya Nivatpumin. Postdural puncture headache. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0027.

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Postdural puncture headache (PDPH) may follow either deliberate or unintentional (accidental) penetration of the interdigitating meninges, the dura and arachnoid mater. It is one of the most common and clinically important complications of regional anaesthesia and analgesia in the obstetric population. The headache develops as a consequence of cerebrospinal fluid loss, low intracranial pressure and cerebrovascular changes in the upright position and can prove debilitating. The diagnosis is clinical, making thorough assessment and regular review all the more important, to revise treatment plans

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Penn, R. D. Intrathecal Drug Therapy for Spasticity and Pain: Practical Patient Management. Springer London, Limited, 2012.

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(Preface), R. D. Penn, ed. Intrathecal Drug Therapy for Spasticity and Pain: Practical Patient Management. Springer, 1995.

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Koman, L. Andrew. Management of Spasticity in Cerebral Palsy: The Role of Intrathecal Baclofen. Data Trace Pub. Co., 2005.

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Book chapters on the topic "Intrathecal injection"

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Herndon, Robert M. "The Medical Uses of Injection into the Cerebrospinal Fluid Space (Intrathecal and Intraventricular Injection)." In The Cerebrospinal Fluid. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1591-9_5.

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Peterson, Cristina D., Alexander G. J. Skorput, Kelley F. Kitto, George L. Wilcox, Lucy Vulchanova, and Carolyn A. Fairbanks. "AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9139-6_11.

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Kemshead, J. T., K. I. Hopkins, and C. L. Chandler. "Treatment of Diffuse Leptomeningeal Malignancy by Intrathecal Injection of 131I Radioimmunoconjugates." In Systemic Radiotherapy with Monoclonal Antibodies. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-79952-5_10.

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Schwarz, M., T. Klockgether, L. Turski, and K. H. Sontag. "Intrathecal Injection of Antispastic Drugs in Rats: Muscle Relaxant Action of Midazolam, Baclofen, 2-Aminophosphonoheptanoic Acid (AP7) and Tizanidine." In Local-spinal Therapy of Spasticity. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72954-6_6.

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Kennedy, Zachary, James W. Gilbert, and Bruno M. D. C. Godinho. "Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_24.

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AbstractTherapeutic oligonucleotides hold tremendous potential for treating central nervous system (CNS) disorders. The route of administration of oligonucleotides significantly impacts both distribution and silencing efficiency. Here, we describe a technically simple, clinically relevant method to administer oligonucleotide compounds into the CNS via direct intrathecal injections. This method achieves distribution throughout the CNS rapidly and permits high-throughput testing of oligonucleotide efficacy and potency in mammals.

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Petitjean, P., P. Mouchet, G. Pellissier, M. Manier, C. Feuerstein, and P. Demenge. "Cardio-vascular Effects of Intrathecal Thoracic Injections of Apomorphine." In Dopaminergic Systems and their Regulation. Palgrave Macmillan UK, 1986. http://dx.doi.org/10.1007/978-1-349-07431-0_80.

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"Intrathecal Injection." In Encyclopedia of Pain. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28753-4_201081.

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Carolina Hernández-Porras, B., Ricardo Plancarte, Angel Manuel Juárez-Lemus, Marcela Sámano-García, Rocío Guillén-Nuñez, and Ale Ismael García-Cazares. "Intrathecal Neurolysis." In Cancer Pain Procedural Techniques, edited by Amitabh Gulati, Neal Rakesh, Grant Chen, Storm Horine, Ali Valimahomed, and Ehtesham Baig. Oxford University PressNew York, 2025. https://doi.org/10.1093/med/9780190933500.003.0041.

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Abstract Cancer pain is of great concern given its severe impact on quality of life. Intrathecal neurolysis is considered when cancer pain in a patient is intractable despite medical and interventional therapies. The anatomical separation of the sensory and motor roots of the spinal nerves within the spinal canal allows this technique to selectively disrupt sensory transmission while preserving motor function. This chapter describes indications for intrathecal neurolysis, patient selection, relevant critical anatomy, step-by-step procedural instructions, perioperative management, and postopera

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"Intrathecal Administration of Local Anesthetics and Glucocorticoids." In Spinal Injection Techniques, edited by Theodoros Theodoridis and Juergen Kraemer. Georg Thieme Verlag, 2009. http://dx.doi.org/10.1055/b-0034-66346.

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McCutchen, Thomas, and J. C. Gerancher. "Epidural Anesthesia: Unintended Intrathecal Injection." In Complications in Anesthesia. Elsevier, 2007. http://dx.doi.org/10.1016/b978-1-4160-2215-2.50064-8.

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Conference papers on the topic "Intrathecal injection"

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Manso, Silvia De Miguel, Rocío Gutiérrez Bustillo, Carlota Gordaliza Pastor, and Pilar Olmedo Olmedo. "#35955 Inadverted intrathecal injection of atropine and anaphylactic shock." In ESRA Abstracts, 40th Annual ESRA Congress, 6–9 September 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/rapm-2023-esra.396.

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Sutherland, Emily, Jonathan Baird-Gunning, Laura Rudaks, Natalie Palavra, Michal Lubomski, and Martin Krause. "075 Gadolinium encephalopathy presenting as status epilepticus following intrathecal injection." In ANZAN Annual Scientific Meeting 2021 Abstracts. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/bmjno-2021-anzan.75.

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Liu, James, Phabinly Gabriel, Gurkirat Kohli, and Jean Eloy. "Direct Orbital Injection of Intrathecal Fluorescein to Identify Orbital Defect Causing Postoperative Pneumocephalus." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679653.

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Shokuhfar, T., P. Nazari, S. Ansari, et al. "P-018 Transforaminal intrathecal access for injection of nusinersen in children with spinal muscular atrophy." In SNIS 15TH ANNUAL MEETING, July 23–26, 2018, Hilton San Francisco Union Square San Francisco, CA. BMJ Publishing Group Ltd., 2018. http://dx.doi.org/10.1136/neurintsurg-2018-snis.54.

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Lueshen, Eric, Indu Venugopal, and Andreas Linninger. "Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93117.

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Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the curre

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Matchynski, James, Rayyan Manwar, Karl Kratkiewicz, et al. "Photoacoustic imaging of fear conditioning neuronal ensembles using a Fos-Lacz gene reporter system in the rat brain in vivo after intrathecal X-gal injection." In Neural Imaging and Sensing 2021, edited by Qingming Luo, Jun Ding, and Ling Fu. SPIE, 2021. http://dx.doi.org/10.1117/12.2579526.

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Gutierrez, Maya, Emmanuelle Mouret Fourme, Emilie Le Rhun, et al. "Abstract P5-19-17: Final results of the phase I "HIT" study: A multicenter phase I-II study evaluating trastuzumab administered by intrathecal injection for leptomeningeal meningitis of HER2+ metastatic breast cancer (MBC)." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p5-19-17.

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Mackie, H., A. Yassin-Kassab, A. Ray, et al. "Rapidly Injecting 10 MG of Intrathecal Fluorescein Caused No Neurologic Complications." In 32nd Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1762249.

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Reports on the topic "Intrathecal injection"

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Koiro, Brenda J. The Effect of the Time of Injection of Intrathecal Analgesia on the Length of Early and Advanced Labor. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ad1012145.

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Wen, Bei, Li Xu, and Yuguang Huang. Which minimally invasive therapy is most effective for the treatment of postherpetic neuralgia? An update meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0114.

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Review question / Objective: Which minimally invasive therapy is the best choice to alleviate pain for patients suffering from postherpetic neuralgia? Eligibility criteria: The eligibility criteria are interpreted under the PICOS (P, participants; I, interventions; C, comparison; O, outcomes; S, study design) framework. (1) P: ParticipantsInclusion criteria: Patients suffering from postherpetic neuralgia (the pain lasting more than 3 months after the onset of herpes zoster rash eruption or more than 1 month after the vesicles have healed).Exclusion criteria: 1. Patients who had other neuropath

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