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Dissertations / Theses on the topic 'Intratumoral CD8 T cells'

Author: Grafiati

Published: 1 February 2025

Last updated: 31 July 2025

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1

PARTINI, BIANCA. "Investigation of intratumoral cd8+ t cell spatiotemporal localization and function." Doctoral thesis, Università Vita-Salute San Raffaele, 2023. https://hdl.handle.net/20.500.11768/136738.

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CD8+ T cells play a crucial role in controlling liver tumours, such as hepatocellular carcinoma (HCC) however we have only limited knowledge of the precise dynamics of their interactions with hepatic parenchymal and non-parenchymal cells at the single-cell level. Previous work from our laboratory, demonstrated that in the context of HBV-expressing hepatocytes circulating effector CD8+ T cells (Teff) perform their immune surveillance function recognizing the antigen and kill virus-expressing hepatocytes extending cytoplasmic protrusions through endothelial fenestrations while still within live

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2

Cinier, Justine. "Importance et potentiel thérapeutique d'un nouveau couple récepteur-ligand dans l'inhibition des lymphocytes T CD8 par les lymphocytes T régulateurs dans les tumeurs." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10336.

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La présence de lymphocytes T (LT) CD8 dans le microenvironnement tumoral (TME) corrèle avec un bon pronostic dans de nombreux types de cancers solides. En périphérie, les LT régulateurs (Treg) jouent un rôle majeur dans le maintien d’une homéostasie immunitaire et empêchent le développement de pathologies auto-immunes. Néanmoins, dans le TME, les Treg (TA-Treg) ont un impact pronostic défavorable en inhibant la réponse immunitaire antitumorale. Sur le plan thérapeutique, il est indispensable d’éliminer ces TA-Treg ou leur fonction pour restaurer une réponse immunitaire antitumorale efficace. P

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3

Granier, Clémence. "Expression de récepteurs inhibiteurs sur les lymphocytes T infiltrant les tumeurs du rein : signification biologique et clinique Multiplexed immunofluorescence analysis and quantification of intratumoral PD-1+ Tim-3+ CD8+ T cells Tim-3 expression on tumor-infiltrating PD-1+CD8+ T cells correlates with poor clinical outcome in renal cell carcinoma." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB183.

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L'expression de récepteurs inhibiteurs tels PD-1, TIM-3, LAG-3, TIGIT sur les lymphocytes T participe à l'immunosuppression dans l'environnement tumoral. Le ciblage de PD-1 par les immunothérapies anti-PD-1/PD-L1 notamment révolutionne depuis peu la prise en charge de nombreux types de cancers en particulier dans le mélanome, cancer du poumon et aussi du rein. Dans la plupart des cancers comme dans celui du poumon et le mélanome, l'infiltrat CD8 et la réponse Th-1/IFN-gamma sont associés à un meilleur pronostic, contrairement aux tumeurs du rein et aux hémopathies. Les travaux de ma thèse s'in

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4

Sepulveda, Homero. "Activation requirements for CD8 T cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9907780.

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5

Mühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.

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ZTLs vermitteln die Eliminierung von infizierten und entarteten Zellen durch Apoptose. Neuste Erkenntnisse unserer Gruppe haben gezeigt, dass eine Subpopulation der CD8+ T-Zellen, anstelle der zytotoxischen Marker das Oberflächenmolekül CD40L exprimiert. Die Expression von CD40L ist bislang als Schlüsselmolekül für die CD4+ T-Zell vermittelte Hilfe bekannt, welche durch Bindung an den CD40 Rezeptor auf anderen Immunzellen induziert wird. Das von den CD4+ T–Zellen ausgehende CD40L Signal ist besonders für die T-Zell abhängige B-Zell Aktivierung und die Bildung von Keimzentren essentiell, in den

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6

Jarvis, Lorna Beth. "Autoreactive CD8+ regulatory T cells in spondyloarthritis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605067.

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There have been substantial advances in our understanding of the CD4+CD25+ regulatory T cell subset, but the possibility of an equivalent regulatory subset within the CD8+ T cell population has received less attention. In the course of studies investigating immunological abnormalities in patients with the inflammatory arthritis Ankylosing Spondylitis (AS), novel human CD8+ T cells that have a regulatory phenotype and function have been identified. CD8+/TCRαβ+ T cells were isolated from the peripheral blood of both AS patients and healthy donors and subsequently expanded as T cell lines using a

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7

Wangteeraprasert, Apirath. "CD8+ T-cells responses in Dengue virus infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39398.

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Dengue virus, which has four serotypes, has several clinical manifestations including asymptomatic infection, a self-limiting febrile illness termed dengue fever (DF) and a severe form characterized by plasma leakage termed dengue hemorrhagic fever (DHF). The pathogenesis of DHF is not fully understood and many studies have shown that it is more prevalent during secondary infection. In addition to a mechanism termed antibody dependent enhancement (ADE), the role of T-cells in the pathogenesis of dengue also has been investigated. It has been hypothesized that upon secondary infection dengue-sp

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8

Istaces, Nicolas. "Transcriptional control of innate memory CD8+ T cells." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/295204.

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CD8+ T cells are essential for host protection against intracellular pathogens and tumors. During antigen-driven responses, CD8+ T cell fate is governed by transcriptional and epigenetic processes that allow naïve CD8+ T cells to develop into a wide range of effector and conventional memory cell subsets. Over the last decades, novel techniques and major efforts led to a better understanding of the origin, nature, and short- and long-term effects of these processes on individual CD8+ T cells. Under certain conditions, naïve CD8+ T cells can acquire memory phenotype and functions in an antigen-i

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9

Su, Charles. "Endogenous Memory CD8 T Cells in Cardiac Transplantation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1404079898.

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10

Raveney, Ben J. E. "Interactions between CD8+ T cells and bone marrow-derived dendritic cells." Thesis, University of Bristol, 2006. http://hdl.handle.net/1983/dbbc656f-a103-4787-aeb9-f203c3f0082b.

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11

Khan, Qasim. "Regulation of apoptosis in CD4§-CD8§- Ãß§+ T cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29310.pdf.

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12

Behrendt, Anne. "Differential antigen dependency of CD4+ and CD8+ T cells." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171521.

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13

Galiano, Landeira Jordi. "Etiopathogenic relevance of CD8+ T cells in Parkinson’s disease." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673969.

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Diferents estudis han assenyalat la importància del sistema immunitari adaptatiu en la etiopatogènia de la malaltia de Parkinson (PD). La infiltració de limfòcits T s’ha descrit tant en models animals com en teixit postmortem humà. Alguns autors han proposat les modificacions post-traduccionals de l’α-sinucleïna com a possible antigen que indueix la resposta immunitària adaptativa. Per tant, l’objectiu principal d’aquesta tesi va ser determinar si els limfòcits T participen en l’inici i la progressió de la PD. A més, volíem saber si l’α-sinucleïna es comportava com un neoantigen. Vam analitzar

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14

Loughhead, Scott McNabb. "Immune Surveillance by Effector and Memory CD8+ T Cells." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718721.

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During priming, CD8+ T cells integrate a plethora of signals that affect their differentiation into subsets of CD8+ T cells with distinct migratory properties and functions. Given that CD8+ T cells exert their protective function via cell-cell contacts, the migratory patterns and spatial distribution of CD8+ T cell subsets induced by primary challenge are of critical importance to the host. Dendritic cells (DCs), as the primary initiators of these responses, play a pivotal role in shaping the size and differentiation status of CD8+ T cells that emerge. However, inadequate markers for CD8+ T ce

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15

Akamatsu, Takuji. "Human TSLP directly enhances expansion of CD8+ T cells." Kyoto University, 2010. http://hdl.handle.net/2433/120576.

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16

Pozzi, Lu-Ann M. "Macrophages Directly Prime Naïve CD8+ T Cells: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/117.

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Professional antigen presenting cells (APCs) represent an important link between the innate and adaptive immune system. Macrophages (MΦs) and dendritic cells (DCs) serve as sentinels in the periphery collecting samples from their environment and processing this information. These cells then present antigenic fragments to T cells in the context of self-MHC molecules. Although a clear role for both of these APCs in the stimulation of already activated or memory T cells has been established, the ability of MΦs to activate naive T cells is still unknown. In this thesis the ability of bone marrow-d

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17

Loyal, Lucie. "The molecular regulation of CD40L in CD8+ T cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20158.

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T Zellen können in zwei Hauptpopulationen mit unterschiedlichen Aufgaben unterschieden werden. CD4+ T Zellen exprimieren im Zuge ihrer Aktivierung CD40L, welches ein zentraler kostimulatorischer Rezeptor zur Induktion von B-Zell basierter humoraler Immunität, APC Aktivierung und einer effizienten Effektor CD8+ T Zell Entwicklung ist („Helfer-Funktion“). Im Gegensatz dazu sind die zytotoxischen CD8+ T Zellen dazu vorbestimmt, infizierte oder maligne Zellen direkt abzutöten. Jedoch wurde eine Fraktion von CD8+ T Zellen identifiziert, die nach Aktivierung CD40L exprimiert. Bisher ist nicht versta

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18

Li, Ming 1957. "Generation of CD8+ T cell immunity with help from CD4+ T cells." Monash University, Dept. of Pathology and Immunology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8476.

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19

Marshall, Heather D. "Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/440.

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Many virus infections induce a transient state of immune suppression in the infected host. Virus-induced T cell suppression can be caused by T cell activation-induced cell death (AICD), dendritic cell (DC) apoptosis, DC dysfunction, and/or the enhanced expression of immune-suppressive cytokines. It has been previously demonstrated that naïve bystander CD8 T cells derived from hosts experiencing an acute virus-specific T cell response underwent AICD when polyclonally activated by anti-CD3 in vitro (Zarozinski et al., 2000). Susceptibility of naïve bystander T cells to AICD could prevent the dev

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20

Kurtulus, Sema. "Mechanisms Regulating Survival of Effector and Memory CD8+ T Cells." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368026339.

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21

Finch, Rosalynde J. "Regulation of interleukin-2 gene transcription in CD8 positive cells /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8352.

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22

Ng, Bernice Yu Jing. "Chronic Inflammation-Driven Tumor Promotion Asociated with CD8+ T Cells." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08232007-122524/.

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Chronic inflammation is associated with carcinoma development in several clinical settings, and we sought to investigate the role of T cells in this phenomenon using the DMBA/TPA two-stage chemical carcinogenesis protocol. We demonstrate that, paradoxical to models of immunosurveillance, wild-type (WT) mice have a markedly higher rate of tumor formation relative to strains lacking CD8+ T cells. Adoptive transfers of antibody-coated magnetic bead-enriched peripheral CD8+ T cells into TCRáâ-/- mice confirmed that the increased mean tumor area and progression to carcinoma was attributable to the

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23

Telaranta, Aino Isadora. "Expression and induction of BCL6B in mouse CD8 T cells." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614359.

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24

Pearson, James. "Analysis of the repertoire of insulin-reactive CD8+ T cells." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/68395/.

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Proinsulin is an auto-antigen in type 1 diabetes in the Non-obese Diabetic (NOD) mouse. The CD8+ T cell clone, G9C8, which utilises a T cell receptor (TCR) comprising TRAV8-1*01TRAJ9 and TRBV19*01TRBD1TRBJ2-3, recognises insulin B15-23 presented by H-2Kd, escapes negative selection and rapidly causes diabetes upon adoptive transfer into immunocompromised NODscid mice. To understand how these insulin B15-23 reactive CD8+ T cells develop, G9C8-derived single TCR TRAV8-1*01TRAJ9 chain transgenic NOD mice were generated. These mice were bred with different proinsulin-expressing NOD mice to generat

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25

Walker, Lucy Jane. "Function, phenotype and development of human CD161+CD8 T cells." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ee5d63dd-5197-492d-af1f-775123444cf9.

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Tc17 cells and the semi-invariant human mucosal associated invariant T (MAIT) cells are important CD8+ tissue-homing cell populations. Both are characterized by high expression of CD161 (++) and type-17 differentiation, yet their origins and relationships remain poorly defined. By transcriptional and functional analyses it is demonstrated that a pool of polyclonal, pre-committed type-17 CD161++CD8αβ+ T cells exists in cord blood, from which a prominent MAIT cell (TCR Vα7.2+/Vβ2 or 13.2) population emerges post-natally. During this expansion, CD8αα T-cells appear exclusively within CD161++CD8+/

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26

Suidan, Georgette Leila. "CD8 T cells mediate CNS vascular permeability under neuroinflammatory conditions." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242912012.

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27

Booty, Matthew Gregory. "Regulation of Effector CD8+ T Cells During Mycobacterium Tuberculosis Infection." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17465317.

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Approximately one-third of the world’s population is currently infected with Mycobacterium tuberculosis (Mtb), the bacillus that causes tuberculosis. Globally, it is the second leading cause of death by a single infectious agent. An effective vaccine is needed to stop this ongoing pandemic, but efforts to design one are hampered by our limited understanding of host immunity to this pathogen. CD8+ T cells are elicited during tuberculosis and are required for optimum host resistance. They produce cytokines such as IFN-γ and can directly lyse infected cells. During infection, the expansion and

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28

Gervassi, Ana L. "Chlamydia trachomatis interactions with human dendritic and CD8⁺ T cells /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9274.

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29

Iga, Natsuko. "Accumulation of exhausted CD8+ T cells in extramammary Paget’s disease." Kyoto University, 2019. http://hdl.handle.net/2433/242908.

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30

Silvestri, Ylenia <1990&gt. "The role of CD8+CCR4+ T-cells in axial spondyloarthritis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/9108/1/silvestri_ylenia_tesi.pdf.

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Axial spondyloarthritis (AxSpA) is an inflammatory disease affecting the axial skeleton. The infiltrate of T-cells in the structural lesions has been found to contribute to bone remodeling, but consensus relating the functional contribution of different T-cell subsets to pathogenesis has not been reached yet. Aim of the project was to characterize circulating T-cells and their homing markers from axSpA patients in order to identify cellular populations that could migrate to inflamed tissues and be implicated in axSpA. We found an altered proportion of circulating naïve and memory T-cells in

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31

Powell, Katie Leanne. "Improving the Potency of a Melanoma Vaccine by Using a Third Co-Stimulatory Molecule." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367230.

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Melanoma is the third most commonly diagnosed form of cancer amongst Australians and Australia has the highest incidence of melanoma in the world. At present, there are no vaccines that are approved for the treatment of melanoma. Previous research performed in the laboratory resulted in the development of a syngeneic, whole cell melanoma vaccine engineered to express high levels of the B7.1 T cell co-stimulatory molecule, in addition to using high doses of interferons to upregulate MHC Class I molecules on the surface of the vaccine cells. Results from extensive mouse trials determined that th

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32

Wolak, Kevin. "Phenotypic and functional characterization of CD8+ memory phenotype T cells in an animal model of CD8+ T cell-mediated demyelinating disease." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92392.

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33

Garefalaki, Anna. "Identification of regulatory regions that determine expression of murine CD8 locus." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250198.

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34

Uss, Alena Iosifovna. "The ins and outs of CD103+CD8+ alloreactive regulatory T cells." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/32477.

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35

Jakobsen, Karen Bang. "MHC clas 1 genes and CD8+T cells in multiple sclerosis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526487.

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36

Woyciechowski, Sandra [Verfasser], and Hanspeter [Akademischer Betreuer] Pircher. "Regulation of tissue-resident memory CD8+ T cells in salivary glands." Freiburg : Universität, 2018. http://d-nb.info/1196526257/34.

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37

Stamou, Panagiota. "Physiology of anergic CD8 T cells in a transgenic mouse model." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398230.

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38

Appay, Victor. "Study of antigen specific CD8+ T cells in HIV-1 infection." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393187.

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39

Rollings, Christina. "The role of JAK1 and JAK3 in CD8⁺ effector T cells." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/03bc71f9-1291-4e6f-9478-11b9b6227f3f.

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The aim of this project was to explore the role of the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the selective JAK3 inhibitor GSK192 on IL-2 control of effector CD8+ cytotoxic T cells (CTL). On the basis of these preliminary data, a detailed analysis of the effect of tofacitinib on effector CD8<sup>+</sup> T lymphocytes was performed. Phosphorylation events regulated by tofaciti

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40

Leitman, Ellen M. "Role of CD8+ T cells in adult and paediatric HIV infection." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:bac3d4ea-49c7-45d4-9f63-af9aeb480486.

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Infection with HIV is a continuing global health problem. Antiretroviral therapy effectively suppresses viraemia, but the viral reservoir in latently infected CD4+ T-cells persists for decades and is the main obstacle to HIV eradication. The central role of CD8+ T-cellmediated immune control of natural adult HIV infection has long been established and recent studies suggest that CD8+ T-cells are likely to be crucial in eliminating reactivated reservoirs. However, the questions of what constitutes an effective anti-HIV CD8+ T-cell response and how to induce it therapeutically are outstanding. M

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41

Elston, Lauren. "Exploring the role of CD8+ T-cells in chronic lymphocytic leukaemia." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/100882/.

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Although chronic lymphocytic leukaemia (CLL) is a B-cell malignancy, T-cells from CLL patients often display abnormal characteristics when compared to age-matched healthy donors. One example is the preferential expansion of CD8+ T-cells within a subgroup of CLL patients resulting in an inverted CD4:CD8 ratio (CLLIR). This thesis describes a detailed analysis of the T-cell compartment with an emphasis on CD8+ T-cells. It confirms that CLL patients have abnormal memory T-cell subset distributions, with skewing to more differentiated memory subsets (EM/EMRA CD8+ T-cells) and an increase in a repl

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42

Ogura, Yasuhiro. "Apoptosis and allograft rejection in the absence of CD8[+] T cells." Kyoto University, 2002. http://hdl.handle.net/2433/149349.

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43

Yang, Edward. "The localization of naive and memory CD8⁺ T cells following infection." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465089.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 22, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 43-45).

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Li, Xiaoying. "T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19552.

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Previous research has provided evidence that CD8 T cells mediate immunity against infection with Theileria parva. However, the immunity induced by one parasite strain doesn‟t give complete protection against other strains and this is associated with parasite strain specificity of the CD8 T cell responses. There is evidence that such strain specificity is a consequence of the CD8 T cell responses of individual animals being focused on a limited number of immunodominant polymorphic peptide-MHC determinants. Dominant responses to the Tp2 antigen have been demonstrated in animals homozygous for th

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45

Wieczorek, Agnieszka [Verfasser]. "In vitro induction and expansion of CD8 positive T cells : a method applicable for the generation of low-frequency antigen specific CD8 positive T cells / Agnieszka Wieczorek." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1032899204/34.

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Purushe, Janaki. "MLL4-Menin Complex Inhibition Promotes Central Memory In CD8 CAR-T Cells." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/489872.

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Infectious Disease & Immunity<br>Ph.D.<br>CAR-T cell immunotherapy is a highly efficacious treatment for CD19-positive hematological malignancies, however, some patients are non-responsive for reasons that are not well understood. Clinical efficacy has been correlated with long-term persistence, a propensity that can be predicted by the differentiation state of transplanted cells. Despite this, decades-old methods for expanding T cells have not been updated to prevent the deleterious effects of excessive differentiation in CAR-T cells. Uncoupling proliferation and differentiation is a long-hel

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47

De, Campos Pereira Lemos Sara Sofia. "CD8 T cell differentiation during immune responses." Phd thesis, Université René Descartes - Paris V, 2014. http://tel.archives-ouvertes.fr/tel-01059806.

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CD8 T cells are essential for the elimination of intracellular pathogens and tumor cells. Understanding how naïve CD8 T cells differentiate into effector cells capable of eliminating pathogens and to generate adequate memory cells during immune responses is fundamental for optimal T cell vaccine design. In this PhD thesis work we addressed two central questions: 1) What are the mechanisms by which early effector T cells could act as pro-inflammatory effectors? And what is their role in the immune response? 2) How heterogeneous are CD8 responses? Could different pathogens modulate CD8 T cell di

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48

Cheung, Kitty Pui Hang. "Memory-like CD8⁺ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3386534.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed Jan, 14, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 108-125).

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49

Kakal, Juzer. "Transcriptional regulation of the CD127 gene in primary human CD8 T-cells." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28090.

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Factors regulating expression of the IL-7 receptor throughout the CD8 T-cell life-span have not been fully characterized but IL-7 has been shown to down regulate the IL-7 receptor alpha-chain (CD127) at the cell surface. Here we show that IL-7 induced a decline in the level of total CD127 transcripts in CD8 T-cells. Also, IL-7 had no effect on CD127 mRNA stability, or alternative splicing. We also find that down regulation of CD127 by IL-7 requires de novo transcript and protein synthesis. Reporter assay analysis of the CD127 promoter showed that sequences up to 3kb upstream of the TATA box ar

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Bannard, Oliver Michael. "The memory functions of CD8⁺ T cells that have expressed granzyme B." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611596.

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