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Journal articles on the topic 'Intravenous antifungal medications'

Author: Grafiati
Published: 11 December 2022
Last updated: 19 July 2025

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1

Mandal, Debashree. "Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments." Oriental Journal Of Chemistry 40, no. 3 (2024): 630–45. http://dx.doi.org/10.13005/ojc/400302.

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Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth. According to their mode of action they are divided into azoles (inhibit ergosterol synthesis), echinocandins (damage cell walls), and polyenes (destroy fungal cells) etc. Depending on the seriousness of infection and type of infection, generally antifungal drugs are administered to a body. Oral antifungals are taken by mouth for systemic infections. Topical antifungals (creams, ointments) treat localized skin
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2

Rukesh Kumar Sharma, Rukesh Kumar Sharma, Parul Verma Parul Verma, Kiran Bala Kiran Bala, Ajeet Pal Singh Ajeet Pal Singh, and Amar Pal Singh Amar Pal Singh. "Antifungals:Effective Treatments for Fungal Infections." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1587–602. https://doi.org/10.35629/4494-100215871602.

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Antifungal agents are medications used to treat infections caused by fungi, which can affect various parts of the body, including the skin, nails, respiratory system, and internal organs. These infections range from superficial conditions, such as athlete's foot and ringworm, to more severe, systemic illnesses like candidiasis and aspergillosis. Antifungals work by targeting the cell structures and functions of fungi, inhibiting their growth or killing them.There are several classes of antifungal agents, each with distinct mechanisms of action. The most common categories include azoles, polyen
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3

AMPEL, Neil M. "THE TREATMENT OF COCCIDIOIDOMYCOSIS." Revista do Instituto de Medicina Tropical de São Paulo 57, suppl 19 (2015): 51–56. http://dx.doi.org/10.1590/s0036-46652015000700010.

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SUMMARYTherapy of coccidioidomycosis continues to evolve. For primary pulmonary disease, antifungal therapy is frequently not required while prolonged courses of antifungals are generally needed for those in whom extrathoracic disseminated has occurred. Intravenous amphotericin B should be reserved for those with severe disease. Oral triazole antifungals have had a great impact on the management of coccidioidomycosis. Both fluconazole and itraconazole at 400 mg daily have been effective for various forms of coccidioidomycosis, including meningitis, although relapse after therapy is discontinue
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4

Grigull, Lorenz, Oliver Kuehlke, Andreas Beilken, et al. "Antifungal Prophylaxis with Oral and Intravenous Itraconazole in Pediatric Stem Cell Tansplantation: A Retrospective Comparison with Fluconazole and Amphotericin B-Preparations in 116 Children." Blood 106, no. 11 (2005): 5356. http://dx.doi.org/10.1182/blood.v106.11.5356.5356.

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Abstract Fungal infections (FI) remain a major threat for patients during allogeneic stem cell transplantation (SCT). There is an ongoing controversy regarding the best fungal prophylaxis. The current study was performed to retrospectively compare three different antifungal medications (itraconazole (ITRA), fluconazole (FLU), and amphotericin B (AMB) preparations) during SCT with regard to FI, survival and complications (toxicity, GVHD, engraftment). 116 children (mean age 10.1 years, female n=48, mean body weight (bw) 27.5 kg) transplanted between March 1998 and August 2003 with complete clin
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5

Novelli, Vas, and Helen Holzel. "Safety and Tolerability of Fluconazole in Children." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 1955–60. http://dx.doi.org/10.1128/aac.43.8.1955.

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ABSTRACT The safety profile of fluconazole was assessed for 562 children (ages, 0 to 17 years) comprising 323 males and 239 females. The data are derived from 12 clinical studies of fluconazole as prophylaxis or treatment for a variety of fungal infections in predominantly immunocompromised patients. Most children received multiple doses of fluconazole in the range of 1 to 12 mg/kg of body weight; a few received single doses. Administration was mainly by oral suspension or intravenous injection. Overall, 58 (10.3%) children reported 80 treatment-related side effects. The most common side effec
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6

Horodyska, T. O., L. M. Lukavetsky, O. M. Tsyapka, et al. "Administration of intravenous immunoglobulin in patients with chronic lymphocytic leukemia and infectious complications." Infusion & Chemotherapy, no. 3.1 (October 11, 2020): 26–28. http://dx.doi.org/10.32902/2663-0338-2020-3.1-22.

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Background. Chronic lymphocytic leukemia (CLL) is one of the most frequent malignant blood disorders in adult patients. For the last several decades treatment of CLL made its way from simple chemotherapy agents (chlorambucil, cyclophosphamide, fludarabine) to highly technological innovative medications (monoclonal antibodies, targeted agents, CAR T-cell therapy). Despite quite high rate of remissions induced by the novel treatment methods significant proportion of the patients develop infectious mostly bacterial complications in the long term. Various infections often become the cause of morta
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7

Da Silva, Juan Felipe Galvão, Yohan Dallazen Oliveira, Ludmila Raynner Carvalho Alves, et al. "Case report: juvenile paracoccidioidomycosis with intestinal involvement." Brazilian Journal of Development 10, no. 1 (2024): 2266–76. http://dx.doi.org/10.34117/bjdv10n1-139.

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Introduction: Contact of Paracoccidioides sp. with the human organism presents in a variety of clinical forms of the disease. Intestinal clinical manifestation is found in 10 to 30% of cases, commonly in juvenile form. This case report seeks to describe a patient with juvenile paracoccidioidomycosis with atypical intestinal involvement. Case report: A 14 years old woman with an updated vaccination schedule and no reports of chronic diseases, allergies or continued use of medications, presented a diarrheal condition that was characterized by pasty stools, where episodes became gradually more in
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8

Bernardo, Valeria, Rochelle Liverman, Ashley Tippett, and Inci Yildirimb. "#28: Serum Posaconazole Concentrations Among Children, Adolescents, and Young Adults Receiving Delayed-Release Tablet And Intravenous Posaconazole." Journal of the Pediatric Infectious Diseases Society 10, Supplement_1 (2021): S1. http://dx.doi.org/10.1093/jpids/piaa170.002.

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Abstract Background Posaconazole is a broad-spectrum antifungal used for prophylaxis and treatment of invasive fungal infections. There are limited data on the optimal dosing, safety, and effectiveness of the delayed-released tablets (DRT) and intravenous (IV) formulations in immunocompromised pediatric and adolescent patients. Methods A retrospective chart review was performed to study all immunocompromised patients who received DRT or IV formulations of posaconazole at our institution from January 1, 2014, to July 31, 2019, and had at least one plasma trough concentration. Plasma concentrati
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9

Busaba, Nicolas Y., Daryl G. Colden, William C. Faquin, and Salah D. Salman. "Chronic Invasive Fungal Sinusitis: A Report of Two Atypical Cases." Ear, Nose & Throat Journal 81, no. 7 (2002): 462–66. http://dx.doi.org/10.1177/014556130208100713.

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The purpose of this article is to describe a chronic variant of invasive fungal sinusitis (IFS) and discuss its management. This is a retrospective review of two cases of IFS that were characterized by atypical clinical courses. Patient 1 was a 75-year-old man with noninsulin-dependent diabetes mellitus who came to us with a 5-month history of headache. Computed tomography detected an opacified left sphenoid sinus. After the man failed to respond to medical therapy, he underwent a left endoscopic sphenoidotomy. Pathologic examination revealed that septate, branching fungal hyphae had invaded t
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10

Wasko, Justin A., James S. Westholder, and Pamala A. Jacobson. "Rifampin–sirolimus–voriconazole interaction in a hematopoietic cell transplant recipient." Journal of Oncology Pharmacy Practice 23, no. 1 (2016): 75–79. http://dx.doi.org/10.1177/1078155215624263.

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Purpose Patients undergoing hematopoietic cell transplantation are treated with multiple medications, potentially complicated by drug–drug interactions. Drug interactions with sirolimus, voriconazole, and rifampin are particularly difficult because of the complex and simultaneous enzyme inhibition and induction mechanisms. We report a hematopoietic cell transplantation patient receiving sirolimus and voriconazole who was given rifampin while being treated for presumed methicillin-resistant Staphylococcus aureus meningitis. Summary A 31 year-old female received a nonmyeloablative allogeneic umb
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11

Seweryn, Marek, Jerzy Wojnar, Dariusz Kata, and Slawomira Kyrcz-Krzemien. "The Use of Purine Analogues Does Not Aggravate Infectious Complications During Induction and Consolidation Therapy of Acute Myeloid Leukemia." Blood 114, no. 22 (2009): 1011. http://dx.doi.org/10.1182/blood.v114.22.1011.1011.

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Abstract Abstract 1011 Poster Board I-33 Background: Addition of purine analogues to standard induction therapy of acute myeloid leukemia (AML) had previously been demonstrated to increase complete remission rate. The aim of this study was to analyze whether the use of cladribine or fludarabine during induction and consolidation increases the risk of infectious complications. Material and methods: 118 AML patients, included in two consecutive randomized trials between 1999-2006 in a single centre were analyzed. Induction therapy consisted of daunorubicin + cytarabine (DA-7, n=53) alone or in c
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12

Addetla, Sagarika* Boreda Sowmya Aprajitha Bhatnagar Dr. Kameswari. "FLUCONAZOLE: A REVIEW." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 1004–8. https://doi.org/10.5281/zenodo.154436.

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Fluconazole is a bis-triazole antifungal drug with novel pharmacokinetic properties (metabolic stability, relatively high water solubility) which contribute to its therapeutic activity. Fluconazole is a medication that is given either by mouth or intravenously. It is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat, and bloodstream. This article describes about the uses of fluconazole drug in immunocompromised patients and in the treatment of other fungal infections. Fungal resistance to drugs in the azole class tends t
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13

Alaedini Taleghani, Roghayyeh, Azar Sabokbar, Zohreh Momeni, and Ghazaleh Maghsoudi. "A Comparative Study of The Effects of Sumac Aqueous and Ethanol Extracts on Candida Albicans in Laboratory Conditions." International Journal of New Findings in Health and Educational Sciences (IJHES) 2, no. 1 (2024): 32–37. http://dx.doi.org/10.63053/ijhes.56.

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Background and purpose: Candida albicans is an opportunistic pathogenic fungus that is considered a member of the human intestinal flora that can survive outside the human body. This fungus is usually a harmless organism, but it can become pathogenic in immunocompromised people under various conditions. For oral infections, treatment with topical clotrimazole or nystatin is usually effective. In case of failure, oral or intravenous fluconazole, itraconazole or amphotericin B may be used. Several topical antifungal medications may be used for vaginal infections, including clotrimazole. This stu
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14

Rodriguez, Rafael A., and Thomas Konia. "Coccidioidomycosis of the Tongue." Archives of Pathology & Laboratory Medicine 129, no. 1 (2005): e4-e6. http://dx.doi.org/10.5858/2005-129-e4-cott.

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Abstract A Spanish-speaking farm worker with type 2 diabetes mellitus presented to our institution with an ulcerating tongue lesion. He was initially evaluated for possible squamous cell carcinoma; however, histologic examination revealed coccidioidomycosis. Coccidioidal titers were elevated and consistent with disseminated disease, although the patient had no systemic symptoms and clinical evaluation was negative. He was ultimately treated with intravenous and oral antifungal medication, which was followed by improvement of his tongue lesion.
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15

Ramadan, El Sayed, Essam M. Sharshira, Ramadan I. El Sokkary, and Noussa Morsy. "Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes." Zeitschrift für Naturforschung B 73, no. 6 (2018): 389–97. http://dx.doi.org/10.1515/znb-2018-0009.

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AbstractA new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-triazolidine-3-thiones, and Knoevenagel condensation products was synthesized from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida a
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16

McQuinn, Erin, Jonathan P. Mochel, David Borts, Andrew S. Hanzlicek, Karin Allenspach, and Jean-Sébastien Palerme. "Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs." PLOS ONE 19, no. 7 (2024): e0305766. http://dx.doi.org/10.1371/journal.pone.0305766.

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Invasive fungal infections (IFIs) are growing in importance in veterinary and human medicine. IFIs such as aspergillosis, blastomycosis, coccidioidomycosis and histoplasmosis remain challenging to treat in dogs. Isavuconazole is a novel antifungal medication that, when compared to currently used azoles, has an expanded spectrum of antifungal activity Rudramurthy (2011), Pfaller (2013), Spec (2018), has more predictable pharmacokinetics in humans Desai (2016), Cojutti (2021) and may cause fewer side effects such as liver and renal toxicity Maertens (2016), DiPippo (2018). The pharmacokinetic pr
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17

Harousseau, J. L., A. W. Dekker, A. Stamatoullas-Bastard, et al. "Itraconazole Oral Solution for Primary Prophylaxis of Fungal Infections in Patients with Hematological Malignancy and Profound Neutropenia: a Randomized, Double-Blind, Double-Placebo, Multicenter Trial Comparing Itraconazole and Amphotericin B." Antimicrobial Agents and Chemotherapy 44, no. 7 (2000): 1887–93. http://dx.doi.org/10.1128/aac.44.7.1887-1893.2000.

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ABSTRACT Systemic and superficial fungal infections are a major problem among immunocompromised patients with hematological malignancy. A double-blind, double-placebo, randomized, multicenter trial was performed to compare the efficacy and safety of itraconazole oral solution (2.5 mg/kg of body weight twice a day) with amphotericin B capsules (500 mg orally four times a day) for prophylaxis of systemic and superficial fungal infection. Prophylactic treatment was initiated on the first day of chemotherapy and was continued until the end of the neutropenic period (>0.5 × 109 neutrophils/liter
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18

Ghule, Amruta Arjun. "Comparative Study of in-Vitro Release of Fluconazole Tablet as Generic and Branded." International Journal of Innovative Science and Research Technology 8, no. 5 (2023): 1712–14. https://doi.org/10.5281/zenodo.7995151.

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The branded drugs are the patent protected.The branded drugs are marketed under a unique proprietary name given by the company.The generic drugs are off the patent.The generic drugs are marketed under the generic name of the drugs . The branded drugs are costly where as the generic drugs are cheap.There is no big difference between the generic and branded drugs.we taken fluconazole as for study purpose.The fluconazole tablet contain NLT 90.0%and NMT 110.0% of the labelled amount of the fluconazole.The fluconazole is the antifungal medication used for a number of the fungal infection eg.. candi
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Saadia, Adi, Jensen Reckhow, Mati Rozenblat, and Omer Last. "Kerion of the pubis and vulva with bacterial superinfection: a rare occurrence." BMJ Case Reports 12, no. 8 (2019): e230320. http://dx.doi.org/10.1136/bcr-2019-230320.

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Kerion is a severe hypersensitivity reaction to fungal infection that is rarely seen in the groin. Frequent shaving of pubic hair and religious conservatism surrounding genital hygiene are common among Bedouin women in the Negev Desert, and may predispose to kerion. This case highlights the clinical course of a 20-year-old Bedouin woman who presented with severe kerion celsi of the pubis and vulva with secondary bacterial infection. The patient was successfully treated with intravenous antibiotics, oral antifungal medication and wet topical dressings. The case outlines the risk factors and tre
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20

LACKNER, H., W. SCHWINGER, C. URBAN, et al. "Liposomal Amphotericin-B (AmBisome) for Treatment of Disseminated Fungal Infections in Two Infants of Very Low Birth Weight." Pediatrics 89, no. 6 (1992): 1259–61. http://dx.doi.org/10.1542/peds.89.6.1259.

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Systemic fungal infections represent an increasing problem among low birth weight neonates.1-4 The necessity of many invasive procedures such as endotracheal intubation, central venous catheterization, prolonged antibiotic therapy, and hyperalimentation including intravenous fat emulsions increases the risk of nosocomial infections.4,5 Amphotericin-B (Amph-B) combined with 5-fluorocytosine is reported to be the treatment of choice for disseminated fungal infections. However conventional Amph-B medication is often limited due to severe side effects. Fever, chills, bronchospastic reactions, neph
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Chan, Xin Hui S., Cristina Cubillo-Garcia, Shanom Ali, et al. "935. A Hospital Cluster of the Emerging Drug-resistant Yeast Saprochaete clavata." Open Forum Infectious Diseases 8, Supplement_1 (2021): S560. http://dx.doi.org/10.1093/ofid/ofab466.1130.

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Abstract Background Saprochaete clavata, an ascomycetous yeast intrinsically resistant to echinocandins, is a rare yet emerging pathogen associated with invasive infections in immunosuppressed patients, particularly those with haematological malignancies. It is commonly misidentified as the closely-related S. capitata. Outbreaks have been associated with a high mortality rate of >50%, due in part to delayed diagnosis and resistance to commonly-used antifungals. Environmental source identification is challenging, although dishwashers and milk flasks have been implicated in previous hospi
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Kumar, Mukta, and William Keough. "Pneumocystis Jirovecii Pneumonia as A Cause of Acute Respiratory Failure In Childhood Acute Lymphoblastic Leukemia." Blood 116, no. 21 (2010): 4876. http://dx.doi.org/10.1182/blood.v116.21.4876.4876.

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Abstract Abstract 4876 Pneumocystis jirovecii is an opportunistic pathogen responsible for severe pneumonia in immunocompromised patients. Management of this pneumonia remains a major challenge for all physicians caring for immunosuppressed patients. The prognosis of Pneumocystis jirovecii pneumonia (PCP) with acute respiratory failure is traditionally known to be poor. We report a case of PCP in a child with recently diagnosed childhood Precursor B cell Acute Lymphoblastic Leukemia (ALL). Course was complicated with acute respiratory failure showing hypoxemia, respiratory failure requiring in
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23

McBride, Ali, Karen Fancher, Jongphil Kim, et al. "Pretransplant Factors That Influence Intravenous Busulfan Kinetics in Adult Patients." Blood 114, no. 22 (2009): 3350. http://dx.doi.org/10.1182/blood.v114.22.3350.3350.

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Abstract Abstract 3350 Poster Board III-238 We performed a retrospective review of intravenous busulfan (Bu) pharmacokinetic (PK) parameters and pretransplant characteristics on patient receiving Bu and fludarabine (40mg/m2/day x 4) (BuFlu) prior to allogeneic hematopoietic cell transplant (HCT) in order to determine the predictive value of pretransplant characteristics on Bu area under the concentration time curve (AUC). Included in this analysis are 265 pts transplanted between 7/04 and 12/08 who received 130 or 145mg/m2/day for 2 doses then had doses 3 and 4 adjusted based on first dose PK
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Aslam, Mohd, Iram Tabish, Mahfooz Alam, et al. "Femoral Vein Access for Central Venous Catheterization as a Rescue for Failed Peripheral Access for Blood Sampling, Intravenous Nutrition, and Drug Delivery." Indian Journal of Vascular and Endovascular Surgery 12, no. 1 (2025): 52–55. https://doi.org/10.4103/ijves.ijves_89_24.

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Abstract Introduction: A central line is crucial to the management of critically ill patients. The decision regarding the insertion of a central line would be to deliver multiple medications for continuous infusion of chemotherapy, for parenteral nutrition, and to deliver vesicant drugs. Materials and Methods: Our study comprised 45 patients, 26 males and 19 female patients, who were catheterized via femoral vein after a failed peripheral access, either due to refusal of consent for subclavian or internal jugular catheterization, unsuccessful access to the internal jugular vein and subclavian
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25

Carnio, Lorenzo R., Mary E. Johnson Shaw, Jack Schnur, and Damian Casadesus. "Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis." BMJ Case Reports 14, no. 1 (2021): e238930. http://dx.doi.org/10.1136/bcr-2020-238930.

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Terbinafine is a commonly used antifungal medication. Its side effects, while widely known, are rarely described and can be missed by the medical community. We present a 55-year-old woman who visited her primary care physician with onychomycosis. She started treatment with terbinafine, and 1 week later developed a rash in the left flank that extended to the chest, back, and upper part of lower extremities. Laboratory results showed elevated liver enzymes. A treatment with steroids did not improve the rash and she was admitted to our institution. She was started with intravenous dexamethasone,
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26

Basas, Vincent, Kristin N. Grimsrud, Emma Sherman, and Tina L. Palmieri. "544 Unlocking Midazolam’s Potential as a Biomarker for CYP3A4 Phenoconversion in Pediatric Burn and Surgery Patients." Journal of Burn Care & Research 45, Supplement_1 (2024): 141. http://dx.doi.org/10.1093/jbcr/irae036.178.

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Abstract Introduction Burn patients, due to hypermetabolism, organ failure, protein binding alterations, inflammatory responses, drug interactions, and other comorbidities, are particularly susceptible to experiencing altered drug metabolism, known as phenoconversion. Phenoconversion is the phenomenon in which an individual's genetically determined metabolism phenotype shifts due to non-genetic factors, such as a normal metabolizer becoming a slow metabolizer. For example, children with sepsis have been reported to exhibit decreased CYP-mediated drug metabolism, antifungals may inhibit CYP met
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27

Grau, Santiago, Carlos Solano, Carol García-Vidal, et al. "Cost Analysis of the Use of Voriconazole, Posaconazole and Micafungin in the Primary Prophylaxis of Invasive Fungal Infections in Recipients of Allogeneic Hematopoietic Stem Cell Transplants." Journal of Health Economics and Outcomes Research 3, no. 2 (2015): 153–61. http://dx.doi.org/10.36469/9832.

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Objectives: Compare the cost of the primary prophylaxis of invasive fungal infections (IFI) with voriconazole, posaconazole, and micafungin in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) in hospitals of the National Health System (NHS) in Spain. Methods: A cost analysis was made for 100 days and 180 days of prophylaxis and a decision tree model was developed. The efficacy rate of IFI prophylaxis and survival rate with liposomal amphotericin B treatment of prophylaxis failures were obtained from randomized trials and a meta-analysis of mixed treatment compariso
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Schmitt-Hoffmann, Anne, Brigitte Roos, Jürgen Maares, et al. "Multiple-Dose Pharmacokinetics and Safety of the New Antifungal Triazole BAL4815 after Intravenous Infusion and Oral Administration of Its Prodrug, BAL8557, in Healthy Volunteers." Antimicrobial Agents and Chemotherapy 50, no. 1 (2006): 286–93. http://dx.doi.org/10.1128/aac.50.1.286-293.2006.

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ABSTRACT BAL8557 is the water-soluble prodrug of BAL4815, a new broad-spectrum antifungal. Healthy male subjects were randomly assigned to four treatment cohorts to receive multiple oral doses or multiple 1-h constant-rate intravenous infusions of BAL8557. Loading doses of BAL8557 were equivalent to 100 mg (followed by once-daily maintenance doses of 50 mg) or 200 mg (followed by once-daily maintenance doses of 100 mg) of BAL4815. In each cohort, six subjects received active drug and two subjects received the placebo. Study duration was 21 days (oral) and 14 days (intravenous). All adverse eve
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29

Kropff, Martin, Peter Liebisch, Hannes Wand, et al. "Dose Definition for Intravenous Cyclophosphamide in Combination with Bortezomib/Dexamethasone for Remission Induction in Patients with Newly Diagnosed Multiple Myeloma." Blood 110, no. 11 (2007): 3599. http://dx.doi.org/10.1182/blood.v110.11.3599.3599.

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Abstract This study was designed to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, and efficacy of intravenous cyclophosphamide (CY) in combination with the proteasome inhibitor bortezomib and high-dose dexamethasone (DEX) for remission induction in younger patients with newly diagnosed multiple myeloma (MM). Patients ≤ 60 years were enrolled to receive three 3-week treatment cycles with bortezomib 1.3 mg/m2/dose on days 1, 4, 8, and 11 in combination with DEX 40 mg/day orally on the day of bortezomib injection and the day thereafter. In addition, patients re
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30

Papadogeorgakis, Nikolaos, Eleni Parara, Vassilios Petsinis, and Christina Vourlakou. "A Case of Successfully Treated Rhinocerebral Mucormycosis: Dental Implications." International Journal of Dentistry 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/273127.

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This paper presents a case of rhinocerebral mucormycosis in a 22-year-old female patient with type I diabetes mellitus, who was successfully treated with surgery and long-term antifungal medication. The patient had initially been submitted to extraction of an upper third molar by a general dental practitioner but was referred to our department three days postoperatively because of double vision. Immediately following histopathological confirmation of the infection, the patient was administered Amphotericin B and Posaconazole intravenously. Surgical excision of the affected site was relatively
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Devasia, Anup Joseph, Olsen Chan, Harjot Vohra, et al. "Incidence and Severity of Hypogammaglobulinemia, and Profile of Infections in Patients with Relapsed Multiple Myeloma Treated with Belantamab Mafodotin." Blood 144, Supplement 1 (2024): 3787. https://doi.org/10.1182/blood-2024-209131.

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Introduction: Preferential expression of B cell maturation antigen (BCMA) in malignant plasma cells has been recognized as a therapeutic target in multiple myeloma (MM). Disruption of BCMA signalling, however, interferes with development of humoral immunity and immunotherapeutic agents, particularly bispecific T cell engagers, directed against this target may increase risk of hypogammaglobulinemia (HGG) and severe infection, in the range of 45-68% with grade 3+ infections. The BCMA-targeting antibody-drug conjugate, belantamab mafodotin (belamaf) has demonstrated benefit in heavily pre-treated
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Krampitz, Barbara, Julia Steiner, Andrej Trampuz, and Klaus-Dieter Kühn. "Voriconazole Admixed with PMMA—Impact on Mechanical Properties and Efficacy." Antibiotics 12, no. 5 (2023): 848. http://dx.doi.org/10.3390/antibiotics12050848.

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Background: There are currently no recommendations to direct the optimal diagnosis and treatment of fungal osteoarticular infections, including prosthetic joint infections and osteomyelitis. Active agents (fluconazole; amphotericin B) are regularly applied per os or intravenously. Other drugs such as voriconazole are used less frequently, especially locally. Voriconazole is less toxic and has promising results. Local antifungal medication during primary surgical treatment has been investigated by implanting an impregnated PMMA cement spacer using intra-articular powder or by daily intra-articu
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H. Vaghela, Sanjaykumar, Ratn Deep Singh, Hitesh B. Patel, et al. "Amphotericin B: Insight into the advances in preclinical and clinical development." Emergent Life Sciences Research 10, no. 01 (2024): 55–71. http://dx.doi.org/10.31783/elsr.2024.1015571.

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Amphotericin B (AmB) is a recognized antifungal drug derived from a natural source that has been used for more than five decades to treat various fungal as well as protozoal infections. In the past two years, the drug has returned to the forefront of medical discussions as the preferred treatment for COVID-19-associated mucormycosis (CAM), popularly known as black fungus infections. AmB acts by binding to ergosterol present in the fungal cells resulting in the formation of pore ion channels and thus making the fungal cell membrane dysfunctional. It also produces free radicals inside fungal cel
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Xu, Rui, Jianfeng Zhang, Jiangnan Zheng, and Qiaozhen Wu. "Allergic bronchopulmonary mycosis due to Schizophyllum commune in a patient with chronic hepatitis B." Journal of Infection in Developing Countries 18, no. 03 (2024): 488–94. http://dx.doi.org/10.3855/jidc.18024.

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Introduction: Schizophyllum commune (S. commune) is an opportunistic pathogenic fungus and can cause infection of the respiratory system in immunocompromised hosts. Allergic bronchopulmonary mycosis (ABPM) is the major disease caused by S. commune. However, identification of S. commune using routine mycological diagnostic methods is difficult. It is easy to make mistakes in diagnosis and treatment, resulting in deterioration of the disease. We report the first case of ABPM due to S. commune in a Chinese patient with chronic hepatitis B. Case presentation: The patient presented cough, sputum an
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35

Rama Mohan Reddy, Gunapati, Usha Kiran Prayaga, and Sekhar Babu Bandar. "STEVENS-JOHNSON SYNDROME (SJS) AND TOXIC EPIDERMAL NECROLYSIS (TEN) ASSOCIATED WITH ANTI-TUBERCULAR DRUGS: A CASE REPORT." International Journal of Advanced Research 10, no. 06 (2022): 420–23. http://dx.doi.org/10.21474/ijar01/14905.

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Introduction: Steven-Johnson syndrome (SJS) is an acute reaction that typically involves the skin and mucous membranes which are characterized by damage and flaking of the skin, accompanied by pain, and can cause death. Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction usually caused by medication,which is characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death.SJS and TEN are some of the rare side-effects from Drugs used in Anti-Tubercular Treatment.we repor
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Oldham, Jaimie, and Portia Goldsmith. "BI41 Azacitidine-induced neutrophilic dermatosis." British Journal of Dermatology 191, Supplement_1 (2024): i156. http://dx.doi.org/10.1093/bjd/ljae090.329.

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Abstract We present the case of a 66-year-old lady with a background of myelofibrosis that had progressed from Janus kinase 2-positive essential thrombocythaemia. She had recently been started on azacitidine and ruxolitinib and had received two cycles of this medication. She was admitted under the care of haematology with progressive pus-filled blisters and had been treated with broad-spectrum intravenous antibiotics for presumed cellulitis with significant deterioration. She was delirious and significantly unwell with a raised respiratory rate, reduced oxygen saturations, hypotension, tachyca
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Neubauer, Werner, Martina Kleber, Alf Zerweck, et al. "Analysis of Efficacy, Safety and Costs of Systemic Antifungal Agents in 159 Consecutive High-Risk Cancer Patients for the Establishment of Standardized Guidelines." Blood 112, no. 11 (2008): 1313. http://dx.doi.org/10.1182/blood.v112.11.1313.1313.

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Abstract Introduction: Invasive mycoses (IM) show high morbidity and mortality rates in immunocompromised patients (pts), especially among allogeneic stem cell transplant (allo-SCT) recipients. Efficacy and safety profiles of currently available systemic antifungal drugs (SAD) have been derived from various clinical trials, which, however, do not reflect ‘everyday clinics’ and true SAD efficacy in cancer pts due to tight inclusion and exclusion study criteria. The aim of our analysis is the development of standard operating procedures (SOP) for SAD use also outside clinical trials, leading to
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Vu, Brandon, Travis Roeder, Jitendra K. Kanaujiya, et al. "Enhancing Hematopoietic Stem and Progenitor Cell Mobilization with 27-Hydroxycholesterol and Cyp7b1 Inhibitors." Blood 144, Supplement 1 (2024): 4774. https://doi.org/10.1182/blood-2024-211675.

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Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow, sustaining blood production. HSPC transplantation is used to treat hematologic malignancies and disorders. Current HSPC collection methods primarily use granulocyte colony-stimulating factor (G-CSF, filgrastim) to mobilize HSPCs from the bone marrow into the bloodstream for collection via apheresis. For donors and patients who do not sufficiently respond to G-CSF alone, AMD3100 (plerixafor), a CXCR4 antagonist, can be used in combination with G-CSF to enhance HSPC mobilization. However, some donors and patients do
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Neubauer, Werner, Alf Zerweck, Alexandra Goebel, Beate Lubrich, Hartmut Bertz, and Monika Engelhardt. "Invasive Mycoses in High-Risk Cancer Patients - a Prospective Analysis of Clinical Parameters, Side Effects, Drug Interactions and Costs for the Safe and Economically Appropriate Use of Systemic Antifungal Agents." Blood 114, no. 22 (2009): 2487. http://dx.doi.org/10.1182/blood.v114.22.2487.2487.

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Abstract Abstract 2487 Poster Board II-464 Introduction: Invasive mycoses (IM) show high morbidity and mortality rates among immunocompromised patients (pts). Especially allogeneic stem cell transplant (allo-SCT) recipients and acute leukemia pts under induction chemotherapy are at risk and benefit from early systemic antifungal drug (SAD) interventions. Nevertheless, the increasing use of SADs has led to considerable costs and represents a substantial burden for public health systems. Available SADs differ in their antifungal properties, side effects (SE), potential drug interactions (PDI) an
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Jette, Nicholas, Colin Gebhardt, and Dimitri Coustinos. "Case report: cardiac tamponade secondary to candida pericarditis." Journal of Surgical Case Reports 2024, no. 3 (2024). http://dx.doi.org/10.1093/jscr/rjae150.

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Abstract Fungal pericarditis, a rare clinical presentation primarily observed in post-cardiothoracic surgery and immunocompromised patients, requires prompt recognition and effective treatment involving antifungal medications and surgical drainage. We report the case of a 40-year-old female initially diagnosed with infective endocarditis who progressed to cardiac tamponade. Timely surgical drainage significantly improved the patient’s clinical status and revealed fungal pericarditis through pathological analysis. This case highlights the importance of considering the diagnosis of fungal perica
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Kumar, Sahil, Swetha Narayanan, Prasan Kumar Panda, and Arnab Chowdhury. "Possible Terbinafine and/or Itraconazole Induced Vasculitis - A Case Study." Current Drug Safety 19 (September 19, 2024). http://dx.doi.org/10.2174/0115748863327130240909044620.

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Introduction: It is essential to exclude other causes, such as autoimmune diseases and bacterial infections, before attributing cutaneous/systemic vasculitis to drug use. Case Study: This report discusses the case of a young man who developed multi-organ failure and cutaneous vasculitis following the use of antifungal medications (terbinafine and itraconazole) for dermatophyte infections. Tests for autoimmune diseases and infections were negative. Given his drug history and a skin biopsy indicating leukocytoclastic vasculitis, it was inferred that the vasculitis was likely drug-induced. Despit
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Singh, Yogendra, Ramanath Karicheri, and Dvijendra Nath. "burden of catheter associated urinary tract infection by candida Albicans and non Albicans with emphasis on biofilm formation and antifungal sensitivity pattern." International journal of health sciences, April 5, 2022, 2356–63. http://dx.doi.org/10.53730/ijhs.v6ns2.5544.

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Candida spp. is generally found in humans; however, when the host's immune system is compromised, the pathogen infects the host, earning it the name opportunistic pathogen. It can also be found on the surfaces of biomaterials such as catheters, Venflon, intravenous tubes, dentures, and blood bags in a medical setting. It infects people who have been admitted to the hospital. This causes major health problems for the patients and raises morbidity and mortality rates over time. Those who take antifungal medications for this infection on a regular basis acquire resistant to the drugs. Candida alb
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Erum Shahzadi, Zarnab Khalid, Sarfraz Latif, Zia-Us-Salam Qazi, Sohail Ahmed Malik, and IKram-Ullah. "RHINO-ORBITO-CEREBRAL MUCORMYCOSIS (ROCM), GRAY AREAS OF MANAGEMENT - A STUDY PRESENTING HIGH INCIDENCE WITH COVID-19." Journal of Ayub Medical College Abbottabad 36, no. 4 (Suppl 1) (2024). https://doi.org/10.55519/jamc-s4-13630.

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Background: Rhino-Orbito-Cerebral Mucormycosis is caused by fungi belonging to the Mucorales family, with Rhizopus arrhizus being the most common causative agent. It is a fatal and debilitating condition that is prevalent in developing countries, with a mortality rate ranging from 50% to 85%, reaching 100% in disseminated or untreated cases. The diagnosis is based on tissue histopathology and culture confirmation. Some studies have assessed the efficacy of antifungal regimens. Limited knowledge of the disease, its diverse presentations, delays in early diagnosis, and insufficient efforts to id
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Trainor, Megan, Emily Henkel, Lucia Z. Diaz, and Ruy Carrasco. "Disseminated coccidioidomycosis in a patient with juvenile idiopathic arthritis receiving infliximab." Pediatric Rheumatology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12969-021-00549-7.

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Abstract Background Coccidioides immitis is a dimorphic fungus endemic to the arid climates of the Southwest United States, Mexico and parts of Central and South America. Human infection occurs through inhalation of spores with less than half of exposures progressing to a symptomatic state that primarily consists of pulmonary manifestations. Disseminated coccidioidomycosis is exceedingly rare, occurring in fewer than 1 % of symptomatic infections. Through hematogenous spread, the fungus can infect most organ systems and may be fatal without systemic antifungal treatment. Individuals with impai
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Gilbar, Peter J., Khageshwor Pokharel, and Hilda M. Mangos. "Temozolomide-induced aplastic anaemia: Case report and review of the literature." Journal of Oncology Pharmacy Practice, October 22, 2020, 107815522096708. http://dx.doi.org/10.1177/1078155220967087.

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Introduction Temozolomide (TMZ) is an oral alkylating agent principally indicated for neurological malignancies including glioblastoma (GBM) and astrocytoma. Most common side effects are mild to moderate, and include fatigue, nausea, vomiting, thrombocytopenia and neutropenia. Severe or prolonged myelosuppression, causing delayed treatment or discontinuation, is uncommon. Major haematological adverse effects such as myelodysplastic syndrome or aplastic anaemia (AA) have rarely been reported. Case report We report a 68-year old female with GBM treated at a tertiary hospital with short-course ra
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Tewkesbury, Daniel H., Evelyn Looi, Peter J. Barry, et al. "Isolation of Exophiala dermatitidis is not associated with worse clinical outcomes during acute pulmonary exacerbations in cystic fibrosis." Journal of Medical Microbiology 71, no. 5 (2022). http://dx.doi.org/10.1099/jmm.0.001431.

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Introduction. The black yeast Exophiala dermatitidis has been isolated in respiratory samples from people with cystic fibrosis (CF). However, adequate detection may require longer incubation periods than the current UK national standard for CF respiratory samples. Furthermore, it is unclear whether isolation of E. dermatitidis is associated with poorer clinical outcomes in CF. Hypothesis/gap statement. E. dermatitidis does not cause clinically significant lung disease in CF adults. Aim. To evaluate differences in clinical outcomes over a 12 month period and during acute pulmonary exacerbations
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Patz‐Sobczak, Caroline, Jennifer Young, Dawn Bunton, Cadence Kuklinski, and Michele Estabrook. "A novel approach to reducing hepatotoxicity related to fungal prophylaxis in pediatric lung transplant recipients." Pediatric Transplantation 28, no. 3 (2024). http://dx.doi.org/10.1111/petr.14740.

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AbstractBackgroundPediatric lung transplant patients are at risk for developing invasive fungal infections post‐transplant. No consensus exists on optimal antifungal regimens and voriconazole, a common first‐line agent, has been shown to cause hepatotoxicity. We describe a single‐center experience utilizing a novel antifungal regimen of intravenous micafungin and nebulized amphotericin B immediately post‐transplant with conversion to an azole at the time of hospital discharge and compare it to a historical cohort of patients who received voriconazole monotherapy throughout their immediate post
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48

Shang, Guangqian, Siqi Zhao, Shuai Yang, and Ji Li. "The heavy burden and treatment challenges of fungal periprosthetic joint infection: a systematic review of 489 joints." BMC Musculoskeletal Disorders 25, no. 1 (2024). http://dx.doi.org/10.1186/s12891-024-07616-6.

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Abstract Background Fungal periprosthetic joint infection (FPJI) is an infrequent but devastating complication that imposes a heavy burden on patients. At present, a consensus regarding the most optimal surgical option for patients with FPJI, the ideal duration of systemic antifungal treatment, and many other issues has not been reached. Methods A comprehensive literature search was performed on the PubMed and Embase databases. The search criteria employed were as follows: (fungal OR candida OR mycotic) AND periprosthetic joint infection. Initially, the titles and abstracts were screened, and
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Cañizares-Cooz, Daniela, Carlos Rojo-Solís, Sonia Rubio-Langre, Daniel García-Párraga, Teresa Encinas, and Pablo Morón-Elorza. "Updates on antifungal pharmacotherapy in elasmobranchs: pharmacokinetics of 4 mg/kg voriconazole after IM and IV administration in undulate skates (Raja undulata) maintained under human care." Frontiers in Veterinary Science 11 (June 6, 2024). http://dx.doi.org/10.3389/fvets.2024.1376851.

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IntroductionFungal diseases are frequently associated with elevated mortality rates in elasmobranchs. Currently, there is a notable absence of scientifically validated therapeutic medications that can ensure both effectiveness and safety when administered to this group of animals. The empirical prescription of azole antifungal agents, particularly voriconazole, has been posited as a potentially efficacious treatment approach for addressing most common mycoses in sharks and rays. However, there are still no published pharmacokinetic studies supporting its use in elasmobranchs and there is a lac
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Gascon, Laurence, Sarah Benyo, and Rebecca C. Nelson. "Immune Checkpoint Inhibitor Induced Supraglottitis: A Case Series." Laryngoscope, May 14, 2024. http://dx.doi.org/10.1002/lary.31492.

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ObjectiveTo report a series of two cases of unusual airway complications with immunotherapy.MethodCase series and review of literature.ResultsWe report two cases of significant supraglottitis in patients treated with immunotherapy. The first patient is a 62‐year‐old male receiving treatment for a stage 4 melanoma with Nivolumab and Relatlimab. He presented in Otolaryngology clinic for subacute dysphonia and dysphagia. Flexible laryngoscopy showed significant airway edema, mucopurulent secretions, and inflammation. He was admitted inpatient and treated with high dose systemic steroids and intra
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