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Journal articles on the topic 'Intravenous Iron Transfusion'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Etemady, Mike, Melika Hajizadeh, Beata Gidaszewski, Julie Ann Swain, Seng Chai Chua, and Marjan Khajehei. "Use of iron in perinatal anaemia: Indications for women’s health care policies and procedure." World Journal of Obstetrics and Gynecology 12, no. 4 (2023): 33–44. http://dx.doi.org/10.5317/wjog.v12.i4.33.

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This paper reviews management of obstetric anaemia and the role of intravenous iron for the treatment of obstetric anaemia. Red blood cell transfusions are routinely used for haemoglobin restoration in anaemic women. The decision for red blood cell transfusion is made on a combination of haemoglobin level and clinical status, and it is suggested that transfusions are not necessary in those who are well compensated or when alternative therapy is available. To reduce the risk, intravenous iron infusion is proposed as a bloodless therapeutic approach. There are a variety of iron preparations. Int

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Beyond Iron: Unmasking Hypophosphatemia in a Young Female Following Intravenous Iron Transfusion: A Case Report." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 3 (2024): 01–03. https://doi.org/10.5281/zenodo.15403356.

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<strong>Abstract</strong> Intravenous iron transfusions, commonly used to treat iron deficiency anaemia, are typically considered safe. However, this case report underscores a rare but noteworthy complication: Hypophosphatemia in a young woman after receiving this treatment. The case report details her clinical presentation, laboratory results, management, and outcome, highlighting the necessity for vigilance and proactive monitoring in similar situations.

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Stepin, A. V. "Supplement intravenous iron therapy in cardiac surgery." Russian journal of hematology and transfusiology 68, no. 2 (2023): 229–40. http://dx.doi.org/10.35754/0234-5730-2023-68-2-229-240.

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Introduction. Preoperative anemia which is present in 25–40 % of cardiac surgery patients increases the risk of adverse postoperative outcomes leading to higher medical expenses. The tendency to restrict allogenic transfusion rate has led to the search for new pharmacological solutions to correct anemia in the perioperative period, nevertheless the usage of intravenous iron preparations in cardiac surgery is still not a generally accepted standard of treatment.Aim — review of the literature about the effects of perioperative intravenous iron therapy on the clinical outcomes in cardiac surgery.

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Engel, Jamie L., Joseph N. Gabra, Patrick Kane, and William J. Kurtz. "Intravenous Iron May Improve Outcomes in Elderly Patients With Operative Hip Fractures." Geriatric Orthopaedic Surgery & Rehabilitation 11 (January 1, 2020): 215145932091184. http://dx.doi.org/10.1177/2151459320911844.

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Introduction: Hip fractures are common injuries with high morbidity and mortality rates. These patients often become anemic and require allogenic blood transfusion. Transfusions are costly with potential complications. This study examines the effect of intravenous (IV) iron on patients with hip fractures, undergoing surgery within 48 hours, and being treated with a highly restrictive transfusion protocol. Materials and Methods: A retrospective chart review performed on patients admitted to a level 1 tertiary care center with fractures of the proximal femur from December 2015 to December 2017 i

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MANIATIS, ALICE. "Intravenous iron as a transfusion alternative." Transfusion Alternatives in Transfusion Medicine 9, s2 Anemia Manag (2007): 13–18. http://dx.doi.org/10.1111/j.1778-428x.2007.00061.x.

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6

Willmann, Patricia A., and Ashley Dean. "Retrospective Review of Total-Dose Iron Dextran in Iron-Deficiency Anemia of Chronic Disease and Relevance to Blood Transfusion Requirements: An Individual Institution Experience." Blood 112, no. 11 (2008): 2876. http://dx.doi.org/10.1182/blood.v112.11.2876.2876.

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Abstract Background: Erythrocyte stimulating agents, iron replacement, and blood transfusions are options in the treatment of chronic anemia. Patients with iron deficiency anemia who cannot tolerate or unable to absorb oral iron may receive intravenous iron. Recent studies have been conducted proving the effectiveness of total-dose low molecular weight iron dextran for the treatment of chronic anemia. Low molecular weight iron dextran (Infed) is FDA approved for to treat iron-deficient anemia and is generally safe and effective. Low molecular weight iron dextran was chosen for this review due

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Barghi, Arvand, Robert Balshaw, Emily Rimmer, et al. "Red Blood Cell Transfusion and the Use of Intravenous Iron in Iron Deficient Patients Presenting to the Emergency Department." Blood 136, Supplement 1 (2020): 1–2. http://dx.doi.org/10.1182/blood-2020-141154.

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Background: Red blood cell (RBC) transfusions are often used to treat patients with iron deficiency who present to the emergency department (ED) with symptomatic anemia. Intravenous (IV) iron is the preferred treatment in this setting, as it has been shown to increase hemoglobin concentration rapidly and durably. We aim to determine the incidence of iron deficiency anemia (IDA) and the management of these patients in the ED setting. Objectives: To evaluate the incidence of IDA, the frequency of RBC transfusion and iron supplementation, and factors associated with RBC transfusion. Study Design:

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Spradbrow, Jordan, Yulia Lin, Dominick Shelton, and Jeannie Callum. "Iron deficiency anemia in the emergency department: over-utilization of red blood cell transfusion and infrequent use of iron supplementation." CJEM 19, no. 3 (2016): 167–74. http://dx.doi.org/10.1017/cem.2016.388.

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AbstractObjectivesThree are no clinical practice guidelines that specifically address the management of patients with iron deficiency anemia (IDA) in the emergency department (ED). The goal of this study was to describe the characteristics of IDA patients who present to the ED, documentation of IDA by emergency physicians, utilization of iron supplementation, and the appropriateness of red blood cell (RBC) transfusions ordered in the ED.MethodsA retrospective medical chart review was performed of IDA patients who visited the ED of a large tertiary center over a three-month period. Appropriaten

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Akshatha and R. L. N. Murthy. "Anaphylactic Reaction due to Ferric Carboxymaltose: A Case Report." Journal of Case Reports in Medical Science 11, no. 1 (2025): 1–6. https://doi.org/10.56557/jocrims/2024/v11i19248.

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This case report describes a 24-year-old female patient admitted with severe iron deficiency anemia, presenting with generalized weakness, easy fatigability, and decreased appetite. The patient was initially treated with oral iron supplements, intravenous iron sucrose, and blood transfusion. However, the patient developed adverse reactions to both blood transfusions and iron sucrose. Subsequently, ferric carboxymaltose (FCM) was administered, but the patient experienced symptoms suggestive of an anaphylactic reaction, including hypotension, respiratory distress, and decreased oxygen saturation

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Richards, Toby, Ravishankar Rao Baikady, Ben Clevenger, et al. "Preoperative intravenous iron for anaemia in elective major open abdominal surgery: the PREVENTT RCT." Health Technology Assessment 25, no. 11 (2021): 1–58. http://dx.doi.org/10.3310/hta25110.

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Background Anaemia affects 30–50% of patients before they undergo major surgery. Preoperative anaemia is associated with increased need for blood transfusion, postoperative complications and worse patient outcomes after surgery. International guidelines support the use of intravenous iron to correct anaemia in patients before surgery. However, the use of preoperative intravenous iron for patient benefit has not been assessed in the setting of a formal clinical trial. Objectives To assess if intravenous iron given to patients with anaemia before major abdominal surgery is beneficial by reducing

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Rekha, Badhe, Thammandra Suchetha Laxmi, Neelima Singh, et al. "Comparative study of postpartum correction of anaemia by iron sucrose vs blood transfusion." International journal of health sciences 6, S1 (2022): 510–21. http://dx.doi.org/10.53730/ijhs.v6ns1.4787.

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Aim: The aim of the study is to know whether intravenous iron sucrose can be a better alternative in terms of safety and efficacy over blood transfusion in the treatment of anaemia in post-partum. Materials and methods: This are prospective study is conducted in obstetrics and gynaecology Department . All these women are randomly assigned (50 women total , 25 in each group) to receive either 2 doses of intravenous iron sucrose(Group A) or blood transfusion (Group B). Haemoglobin, hemocrit, mean corpuscular volume and serum ferritin estimation is done before treatment and after 1 wk. of correct

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Khristian, Erick, Mohammad Ghozali, Muhammad H. Bashari, et al. "Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model." Narra J 4, no. 3 (2024): e1003. http://dx.doi.org/10.52225/narra.v4i3.1003.

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Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis. An experimental design with a post-test-only control group

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Moppett, I. K., M. Rowlands, A. M. Mannings, T. C. Marufu, O. Sahota, and J. Yeung. "The effect of intravenous iron on erythropoiesis in older people with hip fracture." Age and Ageing 48, no. 5 (2019): 751–55. http://dx.doi.org/10.1093/ageing/afz049.

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Abstract Background anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. There is good evidence for its use in elective surgical populations. Objective to examine the impact of intravenous iron on erythropoiesis following hip fracture. Design two-centre, assessor-blinded, randomised, controlled trial of patients with primary hip fracture and no contra-indications to intravenous iron. Method the intervention group re

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Deng, Zhizhi, Xi Zhou, Guicheng He, Na Yang, and Jiming Zhou. "Intravenous iron therapy for treating patients with iron deficiency anaemia during the perioperative period of gynecological malignancy." African Journal of Reproductive Health 28, no. 12 (2024): 82–87. https://doi.org/10.29063/ajrh2024/v28i12.9.

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Anaemia is a common phenomenon in patients with malignant gynecological tumors. The occurrence of anaemia in the perioperative period leads to an increased probability of blood transfusion, increased surgical complications,poor wound healing, prolonged hospitalization, increased medical costs, and increased mortality. Intravenous iron, which is known for its rapid onset and lack of gastrointestinal side effects, has become increasingly prevalent in clinical practice. A total of 300 patients with gynaecological malignancies were admitted to The First Affiliated Hospital,Hengyang Medical School,

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Butler, Anne M., Abhijit V. Kshirsagar, Andrew F. Olshan, Matthew E. Nielsen, Stephanie B. Wheeler, and M. Alan Brookhart. "Trends in Anemia Management in Hemodialysis Patients with Cancer." American Journal of Nephrology 42, no. 3 (2015): 206–15. http://dx.doi.org/10.1159/000440771.

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Background: Erythropoiesis-stimulating agents (ESAs), intravenous iron, and blood transfusion are used to treat anemia in both end-stage renal disease (ESRD) and cancer. However, anemia treatment patterns have not been described among ESRD patients undergoing hemodialysis with concurrent cancer, especially in the recent era of ESA-related safety concerns. Methods: We analyzed Medicare data from a cohort of hemodialysis patients diagnosed with incident cancer. We used multivariable generalized linear models to estimate trends and patterns in ESA use, iron use, transfusion use, epoetin alfa (EPO

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16

Peter, Joel Vasanth, Deepak Narayanan A, J. V. Peter, and Sathish Kumar Dharmalingam. "Pre-Operative Intravenous Iron Therapy in Patients Undergoing Coronary Artery Bypass Surgery on Cardiopulmonary Bypass: A Non-Randomized Study." NATIONAL BOARD OF EXAMINATIONS JOURNAL OF MEDICAL SCIENCES 3, no. 5 (2025): 495–509. https://doi.org/10.61770/nbejms.2025.v03.i05.002.

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Objective: To study if preoperative iron and vitamin B12 supplementation in anaemic patients undergoing coronary artery bypass graft (CABG) surgery would reduce transfusion requirements perioperatively. Materials and methods: In this prospective non-randomised study, consenting patients received 20 mg/kg of ferric carboxymaltose intravenously and 1-mg of vitamin B12 subcutaneously (treatment arm). The control arm did not receive supplements. The primary outcome was perioperative transfusion requirement. Secondary outcomes included duration of ventilation and intensive care stay. The difference

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Machtei, Ayelet, Gil Klinger, Rivka Shapiro, Osnat Konen, and Lea Sirota. "Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment." Case Reports in Critical Care 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/650916.

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Neonatal hemochromatosis (NH) is an acute liver disease associated with both hepatic and extrahepatic iron deposition and is a leading cause of neonatal liver transplantation. The concept that NH is an alloimmune disease has led to the emergence of a new treatment approach utilizing exchange transfusion and intravenous immunoglobulin therapy. We present a two-day old neonate with progressive liver dysfunction who was diagnosed with NH. Magnetic resonance imaging confirmed tissue iron overload. Treatment with intravenous immunoglobulins and exchange transfusion led to rapid improvement in liver

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Thobbi, Vidya A., and Zeba Naz M. Bijapur. "A comparative study of efficacy, safety and compliance of oral iron versus intravenous iron sucrose in treatment of iron deficiency anaemia of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 9 (2020): 3852. http://dx.doi.org/10.18203/2320-1770.ijrcog20203495.

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Background: Iron deficiency anemia is the most common form of anemia and nutritional disorder worldwide. Oral iron therapy and blood transfusion has many drawbacks like noncompliance and risk of transmittable infections and transfusion reaction. The modern alternative therapy is treatment with intravenous iron. Present study compares the efficacy, safety and tolerability between intravenous iron sucrose and oral iron in iron deficiency anemia during 20-36 weeks of pregnancy.Methods: It was a randomized controlled study between December 2017 to September 2019. 200 patients attending antenatal O

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Saber, Mohamed, Mohamed Khalaf, Ahmed M. Abbas, and Sayed A. Abdullah. "Management of postpartum iron deficiency anemia: review of literature." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 1 (2018): 338. http://dx.doi.org/10.18203/2320-1770.ijrcog20185450.

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Anemia is a condition in which either the number of circulating red blood cells or their hemoglobin concentration is decreased. As a result, there is decreased transport of oxygen from the lungs to peripheral tissues. The standard approach to treatment of postpartum iron deficiency anemia is oral iron supplementation, with blood transfusion reserved for more server or symptomatic cases. There are a number of hazards of allogenic blood transfusion including transfusion of the wrong blood, infection, anaphylaxis and lung injury, any of which will be devastating for a young mother. These hazards,

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Jung, Ho Jung, Min Wook Kang, Jong Hwa Lee, Joon Kyu Lee, and Joong Il Kim. "The Association of Intravenous Iron Administered the Day before Total Knee Arthroplasty with Postoperative Anemia and Functional Recovery." Medicina 59, no. 7 (2023): 1212. http://dx.doi.org/10.3390/medicina59071212.

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Background and Objectives: Total knee arthroplasty (TKA) involves blood loss, increasing the risk of postoperative anemia and delayed functional recovery. Intravenous (IV) iron supplementation limits postoperative anemia; however, the effectiveness of IV iron, administered one day before TKA, on postoperative anemia and functional recovery has scarcely been studied. Materials and Methods: We conducted a retrospective cohort study with propensity score matching using two consecutive groups of patients who underwent TKA using tranexamic acid: the iron group received 500 mg ferric derisomaltose i

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Nixon, Christian P., and Joseph D. Sweeney. "Severe iron deficiency anemia: red blood cell transfusion or intravenous iron?" Transfusion 58, no. 8 (2018): 1824–26. http://dx.doi.org/10.1111/trf.14819.

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Jajeh, Ahmad. "Iron Deficiency Anemia Is Common in Patients Receiving Chemotherapy." Blood 126, no. 23 (2015): 4559. http://dx.doi.org/10.1182/blood.v126.23.4559.4559.

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Abstract Background: Iron metabolism is impaired in patients with cancer and actively receiving chemotherapy. Patients with cancer on active chemotherapy suffer with decreased appetite , poor nutrition, mucositis, gastrointestinal mucosal damage, blood loss as well as anemia of chronic disease due to cytokines release such as Tumor Necrosis Factor, Interleukins and histamins. The purpose of this abstract is to show single institution experience with patients actively receiving chemotherapy and admitted for various reasons and found to have anemia and particularly those patients that were admit

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Pfeiffer, Alixandria F., Nathalie H. Chang, CeCe Cheng, John J. Byrne, and Nora M. Doyle. "Intravenous Iron Supplementation in Pregnancy: A Quality Improvement Project on Maternal Transfusion Reduction [ID 2683469]." Obstetrics & Gynecology 143, no. 5S (2024): 34S. http://dx.doi.org/10.1097/01.aog.0001013400.76039.90.

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INTRODUCTION: Intravenous (IV) iron supplementation for patients with iron deficiency anemia in pregnancy has been shown to improve hemoglobin (Hb) levels in the peripartum period and ultimately lead to a decrease in severe maternal morbidity (SMM), specifically blood transfusion. The objective of this study was to analyze the effects of IV iron supplementation on maternal pre-delivery Hb levels after the implementation of an institution-based protocol focused on maternal red blood cell transfusion reduction. METHODS: We performed a retrospective review of patients who received IVFe supplement

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Kizilkurt, Taha, Mustafa Ozkaya, Mert Balli, Mehmet Demirel, and Mehmet Asik. "The Effect of Preoperative Intravenous Iron Supplementation on Mortality and Blood Transfusion Requirements in Elderly Patients Undergoing Hip Fracture Surgery: A Prospective Randomized Controlled Trial." Journal of Clinical Medicine 14, no. 13 (2025): 4713. https://doi.org/10.3390/jcm14134713.

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Background/Objectives: Elderly patients who suffer a hip fracture often have a high risk of complications and mortality, which can be made worse by anemia during and after surgery. Although restrictive transfusion strategies are recommended, the role of preoperative intravenous iron, particularly ferric carboxymaltose (FCM), remains unclear. This study aimed to investigate whether preoperative IV FCM reduces mortality and transfusion requirements in geriatric hip fracture patients managed under a restrictive transfusion strategy. Methods: A study was conducted in which 220 patients aged 65 yea

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Saevets, Valeriya V., and Anna Yu Shamanova. "Clinical and economic benefits of parenteral iron carboxymaltosate in patients with gynecological cancers: A retrospective observational study." Journal of Modern Oncology 25, no. 3 (2023): 373–77. http://dx.doi.org/10.26442/18151434.2023.3.202442.

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Background. Timely diagnosis and treatment of iron deficiency anemia in cancer patients affect the quality of life and the effectiveness of anti-tumor treatment. However, choosing a method for correcting anemia is imperative to achieve maximum efficiency and safety with the least financial costs. Aim. To evaluate postoperative methods for treating iron deficiency anemia in patients with gynecological cancers based on a comparative analysis of the clinical and economic outcomes of intravenous iron carboxymaltosate and blood transfusions. Materials and methods. A study of 125 cases o

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Erichsen, Caroline, Victoria Rosberg, and Peter-Martin Krarup. "Streamlined Preoperative Iron Deficiency Screening and IV Treatment for Colorectal Cancer Patients beyond Clinical Trials." Journal of Clinical Medicine 13, no. 19 (2024): 6002. http://dx.doi.org/10.3390/jcm13196002.

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Background/objectives: Iron deficiency anemia is common in patients with colorectal cancer and affects postoperative outcomes. Preoperative intravenous iron supplementation corrects anemia effectively; however, the effect on the postoperative clinical course is unclear. The aim of this study was to investigate the effects of implementing a screening program for iron deficiency anemia and correction in patients with colorectal cancer. Methods: This was a retrospective single-institutional quality-assurance study that included patients undergoing elective surgery for colorectal cancer between Ja

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Park, Hee-Sun, Tae-Yop Kim, Ha-Jung Kim, Young-Jin Ro, Hwa-Young Jang, and Won Uk Koh. "The Effect of Intraoperative Ferric Carboxymaltose in Joint Arthroplasty Patients: A Randomized Trial." Journal of Clinical Medicine 8, no. 10 (2019): 1674. http://dx.doi.org/10.3390/jcm8101674.

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This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg intravenous ferric carboxymaltose and Group C received normal saline. The changes in hemoglobin (Hb), hematocrit, iron metabolism variables, transfusion rates, and the arterial partial pressure of oxygen and the fraction of oxygen (PaO2/FiO2) ratio were recorded. There were 29 pat

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Garganeeva, A. A., O. V. Tukish, E. A. Kuzheleva, V. A. Fediunina, and B. N. Kozlov. "Iron deficiency in cardiac surgery patients and the possibility of its correction at the preoperative stage." Kardiologiia 63, no. 7 (2023): 68–76. http://dx.doi.org/10.18087/cardio.2023.7.n2471.

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Among cardio-surgical patients, the prevalence of iron deficiency conditions reaches 70 %, and anemia is detected in less than 50% cases. Meanwhile, both anemia and latent iron deficiency are risk factors for adverse outcomes in cardio-surgical patients. These conditions are associated with a high frequency and greater volume of blood transfusions as well as with a longer stay in the hospital. Timely diagnosis and correction of iron deficiency, regardless of the presence of anemia, are mandatory at the stage of preoperative preparation. The use of oral iron medicines is limited by their low ef

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Saevets, V. V., А. Р. Alekseeva, А. V. Taratonov, А. А. Muhin, and А. V. Chizhovskaja. "Analysis of economic efficiency of iron deficiency anemia therapy in patients with malignant tumors." Ural Medical Journal 20, no. 2 (2021): 59–63. http://dx.doi.org/10.52420/2071-5943-2021-20-2-59-63.

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Introduction. Correction of iron deficiency anemia in patients with malignant neoplasms is an important aspect affecting the quality of life and the effectiveness of special treatments. At the same time, the therapy of comorbid conditions significantly increases the cost of treating cancer patients.The aim of the study was to conduct a comparative pharmacoeconomic analysis of the two most common methods for correcting iron deficiency anemia in cancer patients: transfusion of erythrocyte suspension and intravenous iron preparations using iron carboxymaltose as an example.Materials and methods.

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Kullmann, Tamás, and Stéphane Culine. "Treatment of anaemia in medical oncology." Orvosi Hetilap 153, no. 25 (2012): 973–77. http://dx.doi.org/10.1556/oh.2012.29371.

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Development of cytotoxic chemotherapy, which has several side effects, has resulted in the development in supportive care as well. Two families of novel drugs have spread in the care of chemotherapy induced anaemia: human recombinant erythropoietin and intravenous iron. They were praised for the decreased transfusion demand and the increased quality of life. However, if we read the literature critically, our enthusiasm should be decreased. New data show an unfavourable impact of erythropoietin on life expectancy. Furthermore, the health care policy has changed since the introduction of erythro

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Gilbertson, David T., Heng Yan, Hairong Xu, et al. "Development and Validation of a Transfusion Risk Score for Patients Receiving Maintenance Hemodialysis." Kidney360 2, no. 6 (2021): 948–54. http://dx.doi.org/10.34067/kid.0004512020.

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AbstractBackgroundIn patients on dialysis with anemia, avoiding red blood cell transfusions is preferable. We sought to develop and validate a novel transfusion prediction risk score for patients receiving maintenance hemodialysis.MethodsThis retrospective cohort study used United States Renal Data System data to create a model development cohort (patients who were point prevalent and on hemodialysis on November 1, 2012) and a validation cohort (patients who were point prevalent and on hemodialysis on August 1, 2013). We characterized comorbidity, inflammatory conditions, hospitalizations, ane

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Naco, Majlinda, Haxhire Gani, Vjollca Duro, and Eden Naco. "Management of Perioperative Anemia in Patients that Performed Abdominal Major Surgery." Albanian Journal of Trauma and Emergency Surgery 6, no. 1 (2022): 968–75. http://dx.doi.org/10.32391/ajtes.v6i1.241.

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Introduction: Anemia is a recognized predictor of adverse postoperative outcomes in patients during abdominal major surgery. The management of perioperative anemia involves many strategies. Pre-operative anemia has adverse outcomes in major surgery and is called the fourth factor. Anemia was then classified into mild, moderate, and severe depending on hemoglobin level. It is present almost in 40% of patients that performed elective major surgery. Patients with preoperative anemia are associated with an increased rate of blood transfusion together with a risk for high morbidity and mortality. T

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Sungkar, Ali. "The Role of Iron Adequacy for Maternal and Fetal Health." World Nutrition Journal 5, no. 1-1 (2021): 10–15. http://dx.doi.org/10.25220/wnj.v05.s1.0002.

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Nearly half of pregnant women in the world are reported to suffer anemia. And most of them are caused by iron deficiency, while the others by folate, vitamin B12 or vitamin A deficiency, chronic inflammation, parasite infections and hereditary disorders. Anemia in pregnant women is characterized when < 11 g / dL or any time during pregnancy. And when followed by low iron, it's called iron deficiency anemia. Iron plays an important role in many metabolic processes by transporting oxygen and allowing cells to generate energy. Low iron levels during pregnancy leading to anemia, related t

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Fedorova, T. A., O. M. Borzykina, E. V. Strelnikova, et al. "Blood management in patients with uterine myoma and anemia in the perioperative period." Meditsinskiy sovet = Medical Council, no. 16 (October 6, 2022): 19–27. http://dx.doi.org/10.21518/2079-701x-2022-16-16-19-27.

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Introduction. In the structure of gynecological diseases, uterine myoma occupies one of the leading places and is accompanied by abnormal uterine bleeding, anemia, hemodynamic and hemostasiological disorders. Purpose. To optimize the management of the perioperative period in patients with uterine myoma and iron deficiency anemia (IDA) using methods of patient blood management (PBM). Materials and methods. The study group consisted of 94 patients with uterine myoma and IDA, who were examined and treated at the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.

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Wetmore, James B., Yi Peng, Keri L. Monda, et al. "Trends in Anemia Management Practices in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Retrospective Cohort Analysis." American Journal of Nephrology 41, no. 4-5 (2015): 354–61. http://dx.doi.org/10.1159/000431335.

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Background/Aims: Recent changes in clinical practice guidelines and reimbursement policies may have affected the use of anemia-related medications and red blood cell (RBC) transfusions in peritoneal dialysis (PD) and hemodialysis (HD) patients. We sought to compare patterns of erythropoiesis-stimulating agents (ESA) and intravenous (IV) iron use, achieved hemoglobin levels, and RBC transfusion use in PD and HD patients. Methods: In quarterly cohorts of prevalent dialysis patients receiving persistent therapy (>3 months), 2007-2011, with Medicare Parts A and B coverage, we assessed ESA and I

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White, Felicia, Noelle Polakowski, Elena Merlington, et al. "Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia." Children 12, no. 2 (2025): 189. https://doi.org/10.3390/children12020189.

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Background/Objectives: Iron deficiency anemia is common in the pediatric population. Red blood cell transfusions, a common acute treatment, pose well-recognized risks including lung injury, circulatory overload, and immune dysfunction. Intravenous iron, specifically sodium ferric gluconate complex (SFGC), is a potential alternative, however investigation on its use in hospitalized children is lacking. This study aims to describe the physiologic response via change in hematologic values to cumulative dose of SFGC, investigate the effect of cumulative dosing on the amount of RBC transfusions rec

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Fritche, Dominic, Frances Wensley, Yanika L. Johnson, et al. "Intravenous Iron for Perioperative Anaemia in Colorectal Cancer Surgery: A Nested Cohort Analysis." Cancers 17, no. 11 (2025): 1877. https://doi.org/10.3390/cancers17111877.

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Background/Objectives: Iron deficiency anaemia (IDA) is a common complication in patients with colorectal cancer presenting for surgery. Perioperative IDA is associated with increased post-operative mortality and morbidity. The impact on clinical outcomes for the active management of anaemia before surgery, with treatments such as intravenous (IV) iron, is uncertain. Methods: We performed a single-centre nested cohort study, analysing prospectively collected data from patients with colorectal cancer who were treated with IV iron prior to elective major abdominal surgery. Cox proportional hazar

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Dillon, Richard, Ibrahim Momoh, Yvonne Francis, Laura Cameron, Claire N. Harrison, and Deepti Radia. "Comparative Efficacy of Three Forms of Parenteral Iron." Journal of Blood Transfusion 2012 (January 19, 2012): 1–3. http://dx.doi.org/10.1155/2012/473514.

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Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemia and can be used to avoid or reduce the requirement for allogeneic blood transfusion. Several intravenous iron preparations are available commercially which differ in cost, mode of administration and side effect profile. There are few data directly comparing the efficacy of these preparations. In this retrospective single-centre study, we present the results from two hundred and eight patients treated using three different iron preparations (iron dextran, iron sucrose and ferric carboxymaltose) an

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Bisch, Steven P., Lawrence Woo, Olle Ljungqvist, and Gregg Nelson. "Ferric derisomaltose and Outcomes in the Recovery of Gynecologic oncology: ERAS (Enhanced Recovery After Surgery) (FORGE) – a protocol for a pilot randomised double-blinded parallel-group placebo-controlled study of the feasibility and efficacy of intravenous ferric derisomaltose to correct preoperative iron-deficiency anaemia in patients undergoing gynaecological oncology surgery." BMJ Open 13, no. 11 (2023): e074649. http://dx.doi.org/10.1136/bmjopen-2023-074649.

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IntroductionIron-deficiency anaemia is common in gynaecological oncology patients. Blood transfusions are immunosuppressive and carry immediate and long-term risks. Oral iron replacement remains the standard of care but requires prolonged treatment courses associated with gastrointestinal side effects, poor compliance and variable absorption in cancer patients. Intravenous iron has been shown to decrease the need for allogeneic blood transfusion in gynaecological oncology patients undergoing chemotherapy, but the efficacy of this treatment in the preoperative period is unknown. The goal of thi

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Parth, Suresh Kadam, and Ashok Deshpande Sanjivani. "A Hospital Record Based Study Outcome of IV Iron Sucrose in the Treatment of Iron Deficiency in Pregnancy." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 949–55. https://doi.org/10.5281/zenodo.12583571.

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<strong>Introduction:</strong> Intravenous iron sucrose is a promising therapy for increasing haemoglobin concentration; however, its effect on clinical outcomes in pregnancy is not yet established. The present study was aimed to assess the outcome of intravenous iron sucrose in the treatment of iron deficiency in pregnancy. <strong>Methodology</strong><strong>: </strong>This prospective observational study was conducted at a tertiary level care hospital. The research included 125 patients who were diagnosed as anaemia (less than 11 gm/dl) and received intravenous iron sucrose w

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Hitarthi, M. Joshi, J. Patel Devanshu, Bhavasar Rahul, R. Damor Rahul, and M. Mansuri Zainishifa. "Parenteral Iron Sucrose Transfusion in Pregnant Women with Iron Deficiency Anaemia and its Outcome." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 18–24. https://doi.org/10.5281/zenodo.14245157.

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<strong>Introduction: </strong>Iron deficiency anaemia (IDA) is common in pregnancy, characterized by reduced red blood cells or haemoglobin due to low iron levels. Pregnancy increases iron demand to support fetal development and the mother’s blood volume. Insufficient iron intake or absorption can lead to IDA, causing complications like low birth weight, postpartum bleeding, and maternal mortality. Iron Sucrose, an IV preparation, due to its efficacy and safety profile become widely used in patients unable to take oral iron preparation. <strong>Materials and Methodology: 

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Kwak, Sang Gyu, Jae Bum Kwon, Jin Woo Bae, Dong Jin Bae, Dong Kun Kim, and Won-Kee Choi. "Effects of intraoperative or postoperative administration of intravenous iron supplements on hemoglobin recovery in patients with total knee arthroplasty: A systematic review and meta-analysis." Medicine 102, no. 43 (2023): e35744. http://dx.doi.org/10.1097/md.0000000000035744.

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Background: The objectives of the researchers are as follows: First, to investigate whether intraoperative or postoperative administration of Intravenous (IV) iron supplements in patients undergoing primary total knee arthroplasty (TKA) can contribute to the hemoglobin recovery during the postoperative period (between 4 and 8 weeks after surgery). Second, to examine whether the administration of IV iron supplements during or immediately after TKA in patients undergoing primary TKA can reduce the need for allogenic blood transfusion during hospitalization. Methods: Articles published between Ja

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Buchrits, Shira, Oranit Itzhaki, Tomer Avni, Pia Raanani, and Anat Gafter-Gvili. "Intravenous Iron Supplementation for the Treatment of Chemotherapy-Induced Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of Clinical Medicine 11, no. 14 (2022): 4156. http://dx.doi.org/10.3390/jcm11144156.

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Background: The pathophysiology of cancer-related anemia is multifactorial, including that of chemotherapy-induced anemia (CIA). The guidelines are not consistent in their approach to the use of intravenous (IV) iron in patients with cancer as part of the clinical practice. Materials and methods: All randomized controlled trials that compared IV iron with either no iron or iron taken orally for the treatment of CIA were included. We excluded trials if erythropoiesis-stimulating agents (ESAs) were used. The primary outcome was the percentage of patients requiring a red blood cell (RBC) transfus

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Sun, Dou Lin (Rose), Allan Puran, Mohammed Al Nuaimi, et al. "80 To Transfuse or Not to Transfuse: Choosing blood transfusions wisely in young children hospitalized with iron deficiency anemia." Paediatrics & Child Health 27, Supplement_3 (2022): e38-e38. http://dx.doi.org/10.1093/pch/pxac100.079.

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Abstract Background Nutritional iron deficiency anemia (IDA) peaks in prevalence at 6to 36 months of age. Children with severe IDA often present to emergency departments and may be hospitalized. Currently, little is known about the management and use of packed red blood cell transfusion in hospitalized children with severe IDA. The current Canadian Paediatric Society (CPS) Practice Point on iron requirements in the first 2 years of life (February 2021) provides guidance on prevention of iron deficiency and iron therapy; however, there is no guidance on the use of blood transfusion in children

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Yoo, Young-Chul, Jae-Kwang Shim, Jong-Chan Kim, Youn-Yi Jo, Jong-Hoon Lee, and Young-Lan Kwak. "Effect of Single Recombinant Human Erythropoietin Injection on Transfusion Requirements in Preoperatively Anemic Patients Undergoing Valvular Heart Surgery." Anesthesiology 115, no. 5 (2011): 929–37. http://dx.doi.org/10.1097/aln.0b013e318232004b.

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Background The authors investigated the effect of a single preoperative bolus of erythropoietin on perioperative transfusion requirement and erythropoiesis in patients with preoperative anemia undergoing valvular heart surgery. Methods In this prospective, single-site, single-blinded, randomized, and parallel-arm controlled trial, 74 patients with preoperative anemia were randomly allocated to either the erythropoietin or the control group. The erythropoietin group received 500 IU/kg erythropoietin and 200 mg iron sucrose intravenously 1 day before the surgery. The control group received an eq

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Amer, Asmaa Fawzy, Hytham Ibrahim Elatrozy, and Mona Belogh El Mourad. "Erythropoietin as a prophylactic measure against anemia in critically ill patients: A combined prospective and retrospective study." Anaesthesia, Pain & Intensive Care 26, no. 5 (2022): 633–39. http://dx.doi.org/10.35975/apic.v26i5.1988.

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Background & Objective: Critically sick patients often develop moderate to severe anemia, due to various factors. We tested the hypothesis that administering prophylactic recombinant human erythropoietin (rHuEPO) together with early identification and correction of iron deficiency anemia in traumatic brain injury patients would have a positive effect on the incidence of RBCs transfusions. Methodology: One hundred and seventeen head-trauma patients were enrolled. They received 40,000 units of prophylactic rHuEPO, starting on day three after admission and continuing at weekly intervals

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Gómez-Ramírez, Susana, Elvira Bisbe, Aryeh Shander, Donat R. Spahn, and Manuel Muñoz. "Management of Perioperative Iron Deficiency Anemia." Acta Haematologica 142, no. 1 (2019): 21–29. http://dx.doi.org/10.1159/000496965.

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Preoperative anemia affects 30–40% of patients undergoing major surgery and is an independent risk factor for perioperative blood transfusion, morbidity, and mortality. Absolute or functional iron deficiency is its leading cause. Nonanemic hematinic deficiencies are also prevalent and may hamper preoperative hemoglobin optimization and/or recovery from postoperative anemia. As modifiable risk factors, anemia and hematinic deficiencies should be detected and corrected prior to major surgical procedures. Postoperative anemia is even more common (up to 80–90%) due to surgery-associated blood loss

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Smith, Aaron, Tiffany Moon, Taylor Pak, Brian Park, and Richard D. Urman. "Preoperative Anemia Treatment With Intravenous Iron in Patients Undergoing Major Orthopedic Surgery: A Systematic Review." Geriatric Orthopaedic Surgery & Rehabilitation 11 (January 1, 2020): 215145932093509. http://dx.doi.org/10.1177/2151459320935094.

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Introduction: Based upon the Third National Health and Nutrition Examination Survey data, iron deficiency anemia is the cause of at least 20% of cases of anemia in adults over the age of 65. This is especially relevant in patients undergoing major orthopedic surgery as substantial perioperative blood loss is possible, leading to a high rate of allogeneic blood transfusion in total hip replacements, total knee replacements, and hip fracture repairs. Significance: The results of this systematic review may be of interest to clinicians and hospital administrators evaluating the clinical efficacy a

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Rajput, Rucha, Ashish Podey, Tushar Baheti, Bangal V. B, and Sarita Deshpande. "Efficacy, tolerability and safety of intravenous iron sucrose in postpartum anaemia." International Journal of Clinical and Biomedical Research 1, no. 1 (2019): 21–24. http://dx.doi.org/10.31878/ijcbr.2018.51.07.

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Background: Anemia is one of major contributing factor in maternal mortality and morbidity in third world countries and according to the WHO, contributes to 40% maternal deaths. Postpartum anemia is observed in up to 27% of women.It is a common problem throughout the world. Treatment of postpartum iron deficiency anemia includes oral and parenteral iron supplmentaion as well as blood transfusion in severe cases. Methods: This was a prospective longitudinal study carried out in Department of Obstetrics & Gynaecology of PRH, Loni. Total 80 women suffering from postpartum anemia of age above

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Applefeld, Willard N., Jeffrey Wang, Steven B. Solomon, Junfeng Sun, Harvey G. Klein, and Charles Natanson. "RBC Storage Lesion Studies in Humans and Experimental Models of Shock." Applied Sciences 10, no. 5 (2020): 1838. http://dx.doi.org/10.3390/app10051838.

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The finding of toxicity in a meta-analysis of observational clinical studies of transfused longer stored red blood cells (RBC) and ethical issues surrounding aging blood for human studies prompted us to develop an experimental model of RBC transfusion. Transfusing older RBCs during canine pneumonia increased mortality rates. Toxicity was associated with in vivo hemolysis with release of cell-free hemoglobin (CFH) and iron. CFH can scavenge nitric oxide, causing vasoconstriction and endothelial injury. Iron, an essential bacterial nutrient, can worsen infections. This toxicity was seen at commo

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