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Journal articles on the topic 'Intravenous Oxytocin'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Devi, Athokpam Manjushree, and Kriti Bhatnagar. "The third stage of labour: to bleed or not to bleed - revised role of intra-umbilical oxytocin in management of third stage of labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 5 (2017): 1982. http://dx.doi.org/10.18203/2320-1770.ijrcog20171962.

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Background: Background and Objectives: Postpartum haemorrhage is a single largest and leading cause of maternal morbidity and mortality not only in developing countries but also in developed countries. Every 4 minutes one woman dies from pregnancy or child birth related complications. The present study is an attempt to evaluate the scope of using intraumbilical vs intravenous vs intramuscular injection oxytocin for the active management of third stage of labour.Methods: Six hundred pregnant women at term of a singleton pregnancy with spontaneous onset of labour were included in the study and w

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AFRIDI, NIGHAT, and MANZOOR AHMED FARIDI. "MANAGEMENT OF THIRD STAGE OF LABOUR;." Professional Medical Journal 15, no. 01 (2008): 41–48. http://dx.doi.org/10.29309/tpmj/2008.15.01.2695.

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The routine prophylactic administration of an uterotonic agent is an integralpart of active management of the third stage of labor, helping to prevent postpartum haemorrhage (PPH). The two mostwidely used uterotonic agents are: ergometrine-oxytocin (Syntometrine ®) (a combination of oxytocin, 5 internationalunits (iu) and ergometrine, 0.5 mg) and oxytocin, (Syntocinon ®) 10 international units (iu). Objective: To compare theefficacy and safety of intravenous oxytocin, with intramuscularly syntometrine in the management of third stage of labor.Study design: Experimental study. Setting: Departme

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ZAMAN, BUSHRA SHER, MUHAMMAD SHER-UZ-ZAMAN, and SUMERA SIDDIQUE. "PRIMARY POSTPARTUM HEMORRHAGE." Professional Medical Journal 18, no. 01 (2011): 28–31. http://dx.doi.org/10.29309/tpmj/2011.18.01.1853.

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Objective: It is to compare efficacy of Oral Misoprostol with intravenous oxytocin in the management of primary post partum hemorrhage. Design: Quasi experimental study. Place and Duration of Study: Obstetrics and Gynaecology Unit-I, Bahawal Victoria Hospital, Bahawalpur. From 1st December, 2006 to 1st December, 2007. Patients and Method: The study was conducted on 90 patients who went into post partum hemorrhage during the study period. Cases were divided into two groups each having 45 patients fulfilling the inclusion criteria. Group ‘A’ had those who received oral misoprostol 600μg and grou

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Torloni, Maria Regina, Monica Siaulys, Rachel Riera, et al. "Route of oxytocin administration for preventing blood loss at caesarean section: a systematic review with meta-analysis." BMJ Open 11, no. 9 (2021): e051793. http://dx.doi.org/10.1136/bmjopen-2021-051793.

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ObjectivesAssess the effects of different routes of prophylactic oxytocin administration for preventing blood loss at caesarean section (CS).DesignSystematic review and meta-analysis.MethodsMedline, EMBASE, CINAHL, Cochrane Library, BVS, SciELO and Global Index Medicus were searched through 24 May 2020 for randomised controlled trials (RCTs) comparing different routes of prophylactic oxytocin administration during CS. Study selection, data extraction and quality assessment were conducted by two investigators independently. We pooled results in fixed effects meta-analyses and calculated average

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Zahra, Azeem Iffat Naheed Sara Ejaz Khadija waheed* Amna khanum Asim Khan. "COMPARISON OF THE MEAN BLOOD LOSS WITH SUBLINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN IN LOW-RISK FEMALES UNDERGOING NORMAL VAGINAL DELIVERY." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4043–47. https://doi.org/10.5281/zenodo.1045319.

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Background: Oxytocin and Misoprostol are considered to be the two most effective drugs in preventing PPH. But contradiction in literature was observed. So to confirm whether misoprostol is more effective than oxytocin for prevention of PPH, we conducted this study. Objective: To compare the mean blood loss with sublingual misoprostol versus intravenous oxytocin in low-risk females undergoing normal vaginal delivery Material & Methods: This randomized control trial was conducted at Unit IV, Department of Obstetrics and Gynecology, Lady Aitchison Hospital, Lahore. The duration of the study w

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Yaliwal, Rajasri G., Shailaja R. Bidri, and Ashwini S. Navani. "A randomized controlled trial of sublingual Misoprostol - 600µg versus intravenous Oxytocin - 10IU in prevention of post partum hemorrhage during cesarean section." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 10 (2019): 3865. http://dx.doi.org/10.18203/2320-1770.ijrcog20194206.

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Background: Mortality related to pregnancy and childbirth causes half a million women around the world to die annually. About 35% of these deaths are from postpartum hemorrhage (PPH). Prevention of PPH has been advised by the WHO by the use of Oxytocin 10 IU IM or IV and Misoprostol 600 µg in low resource settings in vaginal delivery. However there have been only a few reports on the use of Misoprostol during cesarean section. The best route and dose of Misoprostol is still being debated.Methods: One hundred women with term singleton pregnancy undergoing elective or emergency cesarean section

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Ghazala, Mahmud, Tasnim Nasira, and Fatima Saba. "Oral Misoprostol: A Safe and Effective Alternative in Comparison to Conventional Uterotonic Agents in the Active Management of Third Stage of Labor." Journal of South Asian Federation of Obstetrics and Gynaecology 1, no. 3 (2009): 19–23. http://dx.doi.org/10.5005/jp-journals-10006-1004.

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ABSTRACT Objective To determine the efficacy and safety of oral misoprostol with intravenous oxytocin and syntometrine in the active management of third stage of labor. Methodology 325 women were randomly allocated by convenient sampling to receive either 10 IU of intravenous oxytocin or 10 IU of oxytocin with 0.2 mg of Methergine (syntometrine) or 400 mcg of oral misoprostol at the delivery of anterior shoulder. Main outcome measures were estimation of blood loss > 500 ml, drop in hemoglobin/hematocrit levels and adverse effects of drugs. Results Estimated blood loss was significantly high

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Kashif, Ali, Rizwana Bashir Kiani, Syed Muhammad Asad Shabbir, et al. "Epigastric pain after intravenous administration of oxytocin in patients undergoing lower segment cesarean section: A quasi experimental study comparing intravenous bolus with infusion technique." Anaesthesia, Pain & Intensive Care 24, no. 1 (2020): 50–53. http://dx.doi.org/10.35975/apic.v24i1.1225.

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Aim: To compare the frequency of epigastric pain and uterotonic effect of an equivalent dose of oxytocin administered as an intravenous bolus versus intravenous infusion during elective LSCS under spinal anesthesia. Methodology: We recruited 98 parturients undergoing elective LSCS under spinal anesthesia for this prospective quasi experimental study and divided them into two groups. Group-A received 5 IU of oxytocin as bolus intravenous (IV) injection in 5 sec (bolus group, n= 48), and Group-B (infusion group, n= 50) received 5 IU of oxytocin as an infusion over 5 min. Any complaint of e

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Sharma, Rajyashri. "Oral Misoprostol vs Intravenous Oxytocin Infusion for Induction of Labor in Prelabor Rupture of Membranes." Journal of South Asian Federation of Obstetrics and Gynaecology 8, no. 1 (2016): 4–7. http://dx.doi.org/10.5005/jp-journals-10006-1375.

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ABSTRACT Objectives To compare the efficacy, side effects and safety of oral misoprostol to intravenous oxytocin infusion for induction of labor in prelabor rupture of membranes (PROM). Materials and methods Two hundred and sixty-six women of prelabor rupture of membranes were assigned to receive either oral misoprostol 100 μg 6 hourly to a maximum 3 doses (misoprostol group, n = 142), or escalating doses of oxytocin infusion up to 20 mIU/min in primigravida and up to 10 mIU/min in multigravida (oxytocin group, n = 114). Results Demographic characteristics were similar in both the groups. The

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Rahim, Abubaker Y. H. Abdel, Mohamed A. A. Gadir E. Ounsa, Rayan G. Albarakati, Elsadig Y. Mohamed, and Sawsan M. Abdalla. "Comparison between oxytocin, ergometrine and misoprostol in active management of the third stage of labour: a randomized controlled trial." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 6 (2018): 2076. http://dx.doi.org/10.18203/2320-1770.ijrcog20182313.

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Background: The aim of the present study was to compare the effectiveness of sublingual misoprostol, intravenous infusion of oxytocin, and intravenous infusion of Ergometrine in reducing blood loss during the third stage of labor.Methods: This is a no-random trial study conducted in in Ribat University Hospital, Khartoum among 150 laboring ladies with a healthy singleton pregnancy. After obtaining their written informed consent to participate in the study, they were randomly assigned to one of three possible treatment groups: 400 μg of sublingual misoprostol; 10 IU of intravenous infusion oxyt

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Cahyaningtyas, Dwi Kartika, Evi Diliana Rospia, and Rika Agustina. "Literature Review: Perbedaan Pemberian Oksitosin Profilaksis Secara Intravena dan Intramuskular Terhadap Kejadian Perdarahan Postpartum." Jurnal Kebidanan Malakbi 4, no. 1 (2023): 23. http://dx.doi.org/10.33490/b.v4i1.689.

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Postpartum Haemorrhage is a condition of blood loss of more than 500 cc that occurs within 24 hours after delivery. Postpartum hemorrhage is a significant cause of morbidity and mortality in childbirth. Postpartum Haemorrhage occurs in about 1% to 6% of all deliveries. Uterine atony, the leading cause of primary postpartum hemorrhage, accounts for 70% to 80% of all bleeding. Early prevention in postpartum hemorrhage cases is the usage of uterotonics in the third stage of labor which has become the standard of intervention worldwide. The choice of uterotonic in managing postpartum hemorrhage sh

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Dr, Moatzid Billah Dr. Irfan Ikram Dr. Malik Muhammad Atif. "A COMPARATIVE STUDY OF TWO REGIMES OF OXYTOCIN USAGE DURING THE TIME OF ELECTIVE CESAREAN SECTION THROUGH SPINAL ANESTHESIA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 12909–14. https://doi.org/10.5281/zenodo.3256263.

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<strong><em>Objective: </em></strong><em>The study focused on the comparison of hypotension frequency within oxytocin infusion in elective cesarean section versus intravenous stat bolus oxytocin under spinal anaesthesia. </em> <strong><em>Methods:</em></strong><em> The study held at Jinnah Hospital, Lahore from October 2017 to July 2018. Approvals were obtained from the ethical committee of the hospital. A total number of 160 participants fulfilling inclusion criteria were registered for participation in the research study. Informed consent was obtained from all patients and demographical data

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Kuriakose, Biby Mary, and Veena Nadarajan. "Cardiovascular Effects of Intravenous Oxytocin in Elective Caesarean Section - A Study from Alappuzha, Kerala." Journal of Evolution of Medical and Dental Sciences 10, no. 45 (2021): 3821–26. http://dx.doi.org/10.14260/jemds/2021/773.

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BACKGROUND Oxytocin is a peptide hormone produced in the hypothalamus, stored, and released by the posterior pituitary. Oxytocin is commonly administered during caesarean section to minimise blood loss. It can cause hypotension, tachycardia, arrhythmias, and decrease in cardiac output and ST-T wave changes which may be deleterious in hypovolemic and high-risk cardiac patients. Cardiovascular effects of oxytocin have not been well investigated. The purpose of this study was to determine the cardiovascular effects of oxytocin (5U) administered as rapid intravenous infusion over 1 minute followed

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Meena, Banwari Lal. "Use of Oral Misoprostol, Intramuscular Oxytocin and Intravenous Methergin in Prevention of Postpartum Haemorrhage." Nepal Journal of Obstetrics and Gynaecology 8, no. 1 (2013): 34–36. http://dx.doi.org/10.3126/njog.v8i1.8859.

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Aims: The purpose of the study was to compare the efficacy of misoporstol 600mg orally (Group A), injection oxytocin 10 IU intramuscularly (Group B) and injection methylergometrine 0.2 mg intravenously (Group C) on reducing blood loss in third stage of labour, duration of third stage of labour, effect on haemoglobin of the patient, need of additional oxytocics or blood transfusion and associated side effects and complications. Methods: A prospective study enrolling 510 women and randomising them into three groups was done in S P Medical College, Bikaner, Rajasthan, India. Active management of

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Benoussaidh, Anissa, Yves Maurin, and Olivier Rampin. "Spinal effects of oxytocin on uterine motility in anesthetized rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 2 (2004): R446—R453. http://dx.doi.org/10.1152/ajpregu.00117.2004.

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The rat uterus receives an innervation from the lumbosacral and thoracolumbar segments of the spinal cord. These segments receive descending oxytocinergic projections from the paraventricular nucleus of the hypothalamus. We tested the hypothesis that oxytocin regulates uterine motility through a spinal site of action. Oxytocin was administered in anesthetized female rats either intrathecally at the lumbosacral or thoracolumbar spinal cord levels or intravenously. Uterine activity was revealed by measuring changes of intrauterine pressure using an indwelling balloon placed in one caudal uterine

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Maskey, S., M. Singh, and S. Rawal. "Comparison of oral misoprostol with intravenous oxytocin for induction of labour in premature rupture of membranes." Journal of Institute of Medicine Nepal 35, no. 2 (2013): 65–70. http://dx.doi.org/10.59779/jiomnepal.623.

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Introduction: To compare the effectiveness of oral misoprostol with intravenous oxytocin for induction of labor in premature rupture of membranes (PROM) at term. Methods: This randomized comparative study was carried out in 100 women who were at or beyond 37 weeks of gestation with cephalic presentation, had PROM more than 12 hours with bishop’s score less than six. Out of 100 women 50 were induced with 50 μg of oral misoprostol 4 hours apart (max 6 doses) and other 50 received intravenous oxytocin infusion (max 3 pints). Results: The parity, mean bishop’s score of two groups were comparable.

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Rathore, Monika, Anjali Gupta, and Nidhi Kumari. "Efficacy of prophylactic tranexamic acid administration in prevention of postpartum hemorrhage in placenta previa cesarean section: an interventional study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 1 (2021): 153. http://dx.doi.org/10.18203/2320-1770.ijrcog20215094.

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Background: Postpartum hemorrhage accounts for the major part of the mortality as well as morbidity like severe anemia, need for blood transfusion, hospital stay and infection. Aim and objectives of the study were to determine the efficacy and safety of prophylactic tranexamic acid and intravenous tranexamic acid in preventing postpartum hemorrhage in women undergoing caesarean section for placenta previa.Methods: Seventy women with placenta previa over 1 year, randomized into 2 groups: group 1 (n=35): Women who received 10 IU oxytocin intravenous infusion after placental delivery and group 2

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ABDULLAH, MUHAMMAD, RAHEEL -, TARIQ ABASSI, Tassaduq Khurshid, and Asim Ghauri. "OXYTOCIN IV BOLUS VS INFUSION;." Professional Medical Journal 19, no. 03 (2012): 382–85. http://dx.doi.org/10.29309/tpmj/2012.19.03.2155.

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Introduction: Obstetric texts advocate the use of oxytocin, either intramuscularly or as a dilute infusion, but warn against the useof intravenous bolus oxytocin, fearing significant maternal hemodynamic consequences. Objective: To compare the hemodynamic effects ofoxytocin given intravenous bolus versus infusion form. Study design: Randomized clinical trial. Setting: Study was conducted in mainoperation theatre and OPD of Combined Military Hospital, Rawalpindi. Duration of study: Study was carried out over a period of six monthsfrom 24-03-2009 to 23-09-2009. Subjects and methods: Total 138 pa

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McCafferty, Gerald P., Mark A. Pullen, Charlene Wu, et al. "Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 1 (2007): R299—R305. http://dx.doi.org/10.1152/ajpregu.00057.2007.

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Spontaneous and induced uterine contractions in the rat were found to be inhibited by a novel and selective oxytocin receptor antagonist GSK221149A (3 R,6 R)-3-Indan-2-yl-1-[(1 R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]-6-[(1 S)-1-methylpropyl]-2,5-piperazinedione. GSK221149A displayed nanomolar affinity ( Ki = 0.65 nM) for human recombinant oxytocin receptors with >1,400-fold selectivity over human V1a, V1b, and V2 receptors. GSK221149A had similar affinity ( Ki = 4.1 nM) and selectivity for native oxytocin receptors from rat and produced a functional, competitive block o

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Shetty, Shukla S., Sneha Sneha, and Prathusha K. "Titrated Oral Misoprostol Solution Compared with Intravenous Oxytocin Infusion for Labour Augmentation." Journal of Evolution of Medical and Dental Sciences 10, no. 17 (2021): 1219–23. http://dx.doi.org/10.14260/jemds/2021/260.

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BACKGROUND The ability to induce and augment labour has been of keen interest to many societies from the time immemorial till date. For majority of the women, the process of labour starts spontaneously at or near term and would result in vaginal “delivery.”1 Augmentation refers to the stimulation of spontaneous contractions that are considered inadequate because of failed cervical dilatation and foetal descent5. The purpose should be to relieve the parturient from the prolonged painful and exhausting delivery process into a short time frame. We wanted to compare the efficacy of titrated oral m

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Saqib, Shazia, Sabeena Umer, Saadia Khanam, Asma Qamar Mudassir, Nosheen Bano, and Hafsa Mubashir. "Comparison of Intravenous Versus Intra-Umbilical Oxytocin for Blood Loss and Placental Separation Time for Active Management of Third Stage of Labour." Pakistan Journal of Medical and Health Sciences 16, no. 9 (2022): 298–99. http://dx.doi.org/10.53350/pjmhs22169298.

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Objectives: To comparison intravenous (IV) versus intra-umbilical oxytocin for blood loss and placental separation time for active management of third stage of labour (TSL). Methodology: This randomized controlled trial was done at “The department of Obstetrics & Gynaecology”, Sialkot Medical College, Sialkot, Pakistan from December 2021 to May 2022. A total of 100 women (50 in each group), aged 18-40 years with singleton cephalic pregnancy having active labour were randomly allocated to either Group-A (IV oxytocin) or Group-B (intra-umbilical oxytocin). Time of placental separation along

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Kovacheva, Vesela P., Mieke A. Soens, and Lawrence C. Tsen. "A Randomized, Double-blinded Trial of a “Rule of Threes” Algorithm versus Continuous Infusion of Oxytocin during Elective Cesarean Delivery." Anesthesiology 123, no. 1 (2015): 92–100. http://dx.doi.org/10.1097/aln.0000000000000682.

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Abstract Background: The administration of uterotonic agents during cesarean delivery is highly variable. The authors hypothesized a “rule of threes” algorithm, featuring oxytocin 3 IU, timed uterine tone evaluations, and a systematic approach to alternative uterotonic agents, would reduce the oxytocin dose required to obtain adequate uterine tone. Methods: Sixty women undergoing elective cesarean delivery were randomized to receive a low-dose bolus or continuous infusion of oxytocin. To blind participants, the rule group simultaneously received intravenous oxytocin (3 IU/3 ml) and a “wide-ope

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Noor, Zainab, Shagufta Liaqat, Misbah Khurshid, and Asif Ali. "Efficacy of Vaginal Prostaglandin E2 Versus Oxytocin for Induction of Labour in Patients with Premature Rupture of Membranes." Biological and Clinical Sciences Research Journal 6, no. 5 (2025): 27–30. https://doi.org/10.54112/bcsrj.v6i5.1720.

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Prelabour rupture of membranes (PROM) at term is a common obstetric complication that necessitates timely labor induction to reduce maternal and neonatal morbidity. While both oxytocin and prostaglandin E2 (PGE2) are used for induction, their comparative efficacy remains under-investigated in low-resource settings such as Pakistan. Objective: To compare the efficacy of vaginal prostaglandin E2 versus intravenous oxytocin for labor induction in patients with term PROM in terms of timely vaginal delivery and reduction in cesarean rates. Methods: A randomized controlled trial was conducted over s

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Mitwally, Abo Bakr Abass, Abanoub Mansour Tawfik Mansour, and Abdel-Ghaffar Mohamed Ahmed. "Four hundred micrograms buccal misoprostol versus five units intravenous oxytocin in prevention of postpartum hemorrhage in elective caesarean section, randomized controlled study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 4 (2022): 1085. http://dx.doi.org/10.18203/2320-1770.ijrcog20220888.

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Background: The number of studies has been increased about the use of misoprostol during caesarean delivery to prevent obstetric hemorrhage, but may be no study compare buccal misoprostol versus oxytocin in prevention of obstetric hemorrhage during and post cesarean section. Our study is done to compare buccal misoprostol 400 mcg versus oxytocin 5iu intravenous bolus in prevention of postpartum hemorrhage during and post elective cesarean section.Methods: A prospective registered, double blinded, randomized controlled trial Operative list or emergency unit at Obstetrics and Gynecology Departme

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Abdelaleem, Ahmed A., Nasser A. Abdelaleem, and Ahmed M. Abbas. "Intrauterine Misoprostol versus intravenous Oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss: a randomised clinical trial." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 4 (2019): 1662. http://dx.doi.org/10.18203/2320-1770.ijrcog20191238.

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Background: The objective of the present study was to compare the efficacy of intrauterine misoprostol with intravenous oxytocin infusion in reducing blood loss during and after cesarean section (CS).Methods: An open, randomized, clinical trial, registered (ClinicalTrials.gov ID: NCT03148574) conducted between July 1, 2017 and April 1, 2018. The study included 240 pregnant females that were recruited at term (37-40 weeks) gestation scheduled for either elective or emergency CS. Eligible participants were randomly allocated into two equal groups: Group A: patients who receive intravenous infusi

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Fatima, Naheed, Tehmina Kanwal, Sumbal Andleeb Choudhary, Saadia Zia, Hira Iram, and Lubna Saleem. "Intravenous Oxytocin Versus Oxytocin Combined with Misoprostol in the Management of the Third Stage of Labor in Vaginal Delivery." Pakistan Journal of Medical and Health Sciences 17, no. 4 (2023): 614–16. http://dx.doi.org/10.53350/pjmhs2023174614.

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Objective: This study was aimed to compare the treatment of the third stage of labour in vaginal delivery between intravenous (IV) oxytocin and IV oxytocin + sublingual misoprostol in primigravida with singleton pregnancy. Background: Worldwide, over 290,000 women pass away each year either during pregnancy, labour, or the first six weeks following delivery. The most frequent primary cause of maternal mortality in underdeveloped nations is still postpartum haemorrhage (PPH). To prevent atonic postpartum haemorrhage, uterotonic medications are employed. These medications include misoprostol, ox

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Pervin, Mst Shahana, Shamima Haque, and Jahanara Rahman. "Outcome Of Induction Of Labour By Intravaginal Prostaglandin Versus Intravenous Oxytocin In a Tertiary Care Hospital." Journal of Dhaka National Medical College & Hospital 17, no. 2 (2012): 30–33. http://dx.doi.org/10.3329/jdnmch.v17i2.12213.

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Aim of the study was to determine the effectiveness and safety of intravaginal misoprostol VS intravenous oxytocin in induction of labour and to compare the induction delivery interval between prostaglandin induction and oxytocin induction and to detect maternal and foetal outcome between prostaglandin induction and oxytocin induction and also reduce the rate of caesarean section . A prospective, randomized trial was carried out in one hundred singleton pregnant women admitted in Dhaka National Medical Hospital during the period of January 2006 to December 2006. Women who had unfavorable cervi

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Williams, T. D. M., D. C. Abel, C. M. P. King, R. Y. Jelley, and S. L. Lightman. "Vasopressin and oxytocin responses to acute and chronic osmotic stimuli in man." Journal of Endocrinology 108, no. 1 (1986): 163–68. http://dx.doi.org/10.1677/joe.0.1080163.

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ABSTRACT The regulation of both arginine vasopressin (AVP) and oxytocin secretion was studied during rapid and prolonged osmotic stimuli in normal adult volunteers. In five subjects given an intravenous infusion of 0·85 mol NaCl/l at 0·05 ml/kg per min over 2 h there was a significant (P<0·05) rise only in plasma AVP, with no significant change in plasma levels of oxytocin. In six further subjects 5 days of restriction to 500 ml fluid daily resulted in significant increases of both plasma and 24-h urinary AVP, whereas there was no change in corresponding oxytocin levels. During another 5-da

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Ewuoso, Dr Bernard O. "Sublingual Misoprostol in Active Management of the third Stage: Maternal Outcome." Journal of Medical Science and clinical Research 12, no. 11 (2024): 01–10. https://doi.org/10.18535/jmscr/v12i11.01.

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Background: The use of uterotonic agents in active management of the third stage of labor has been shown to reduce postpartum hemorrhage. Although intramuscular oxytocin remains the uterotonic of choice, others such as intravenous oxytocin, ergometrine, carboprost, and misoprostol can be used. Sublingual misoprostol has been shown to have the greatest bioavailability, achieving the highest plasma concentration in the shortest time when compared to other routes at equal dose. Objective: To evaluate whether the addition of sublingual misoprostol to intramuscular oxytocin in active management of

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Begum, Nasima, Tahamina Khanum, Rahima Khatun, and Nelufa Tahera Rahman. "Hemodynamic Effects of Oxytocin when Given as Bolus or Slow Intravenous Infusion During Cesarean Section." Journal of Enam Medical College 11, no. 2 (2021): 92–98. http://dx.doi.org/10.3329/jemc.v11i2.65191.

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Background: Oxytocin is a uterotonic drug with profound haemodynamic effects. The effects of oxytocin on women undergoing cesarean section include tachycardia, hypotension and decreased cardiac output. These can be sufficient to cause significant compromise in high risk patients. Objective: This study aims to find out a simple way to decrease these risks without compromising the therapeutic benefits such as decreasing bleeding after delivery and uterine contraction. Materials and Methods: We recruited 60 women undergoing cesarean section. The subjects were randomly divided into two groups, 30

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Orji, Ernest O. "Safety and efficacy of vaginal misoprostol versus transcervical foley catheter and intravenous oxytocin for induction of labour." Nepal Journal of Obstetrics and Gynaecology 3, no. 2 (2014): 12–15. http://dx.doi.org/10.3126/njog.v3i2.10825.

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Introduction: A variety of drugs were used for induction of labour, but only oxytocin and prostaglandins have survived critical test of effectivity with a minimum of side effects for mother and child. The objective of this study is to compare efficacy and safety of vaginal misoprostol with transcervical Foley’s catheter and intravenous oxytocin for induction of labour. Methods: Eighty women at term gestation with the Bishops score < 4 with various indications for labour induction were randomly allocated to receive 25 microgram misoprostol vaginally 4 hourly (maximum 6 doses) or transcervica

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Arti, Kumari, and Sinha Anupama. "Role of Increased Hydration in Women In progress of Labor with unrestricted oral Intake of Fluids." International Journal of Pharmaceutical and Clinical Research 16, no. 7 (2024): 990–92. https://doi.org/10.5281/zenodo.13187465.

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<strong>Introduction: </strong>Increased intravenous hydration reduces the labor duration and oxytocin augmentation when oral fluid is restricted. <strong>Aims: </strong>The objective of this study is to compare duration of labor, need for oxytocin augmentation and the mode of delivery in women with unrestricted intake of oral fluids. <strong>Methodology: </strong>On randomization, out of 60 women, 30 will be allowed to take unrestricted oral fluids and the remaining 30 were encouraged to take more fluids along with IV fluids. <strong>Results: </strong>There

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Hong, Soon Cheol, Ji Won Kim, Hyun Tae Park, et al. "321: Additional rectal misoprostol plus intravenous oxytocin versus intravenous oxytocin for the prevention of postpartum hemorrhage after cesarean section." American Journal of Obstetrics and Gynecology 197, no. 6 (2007): S99. http://dx.doi.org/10.1016/j.ajog.2007.10.336.

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Mittal, Shivika, Amit Gupta, Chanderdeep Sharma, Prashant Dhatwalia, and Rita Mittal. "A comparative study on the effect of intravenous Ringer lactate at 125 ml/hour versus 250 ml/hour on the duration of labour in nulliparous pregnant women." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 3 (2023): 711–15. http://dx.doi.org/10.18203/2320-1770.ijrcog20230543.

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Background: Several factors may influence the progression of normal labour. It has been postulated that the routine administration of intravenous fluids to keep women adequately hydrated during labour may reduce the period of contraction and relaxation of the uterine muscle, and may ultimately reduce the duration of the labour. However, the routine administration of intravenous fluids to labouring women has not been adequately studied although it is widely practiced, and there is no consensus on the type or volume of fluids that are required, or indeed, whether intravenous fluids are at all ne

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Freeman, Sara M., Sridhar Samineni, Philip C. Allen, et al. "Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques." Psychoneuroendocrinology 66 (April 2016): 185–94. http://dx.doi.org/10.1016/j.psyneuen.2016.01.014.

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Sitaula, Sarita, DK Uprety, A. Thakur, and T. Pradhan. "Impact of Preoperative Rectal Misoprostol on Blood Loss during and after Elective Cesarean Delivery: A Randomized Controlled Trial." Nepal Journal of Obstetrics and Gynaecology 11, no. 2 (2017): 37–41. http://dx.doi.org/10.3126/njog.v11i2.17460.

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Aims:The aim of this study was to evaluate the effect of preoperative administration of rectal misoprostol onblood loss during and after elective cesarean delivery.Methods:It was a randomized trial including 200 women, divided into two groups (group A and group B), who were planned for elective cesarean delivery and didn’t have risk of postpartum hemorrhage (PPH). Group A received 400μg misoprostol per-rectal preoperatively and intravenous infusion of oxytocin after delivery as hospital protocol.Group B received only intravenous infusion of oxytocin. Primary outcome measureswere the estimated

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Janjua, Mahham, and Maria Imran. "A COMPARISON OF THE EFFECTIVENESS OF SUBLINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN INFUSION IN REDUCING BLOOD LOSS IN FIRST TWO HOURS AT CAESAREAN SECTION." Pakistan Postgraduate Medical Journal 31, no. 03 (2021): 132–37. http://dx.doi.org/10.51642/ppmj.v31i03.350.

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OBJECTIVE The objective of the study was to compare the effectiveness of sublingual misoprostol in reducing intraoperative and postoperative blood loss with that of intravenous (IV) oxytocin infusion in the first two hours at cesarean delivery. STUDY DESIGN Randomized controlled trial PLACE AND DURATION OF STUDY The study was conducted in Lady Aitchison Hospital, Lahore unit IV-King Edward Medical University, and the duration of the study was one year. MATERIALS and METHODS Eighty-two women with term singleton pregnancy undergone elective cesarean sect

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Robinson, Kelly J., Sean D. Twiss, Neil Hazon, Simon Moss, and Patrick P. Pomeroy. "Positive social behaviours are induced and retained after oxytocin manipulations mimicking endogenous concentrations in a wild mammal." Proceedings of the Royal Society B: Biological Sciences 284, no. 1855 (2017): 20170554. http://dx.doi.org/10.1098/rspb.2017.0554.

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The neuropeptide hormone oxytocin modulates numerous social and parental behaviours across a wide range of species, including humans. We conducted manipulation experiments on wild grey seals ( Halichoerus grypus ) to determine whether oxytocin increases proximity-seeking behaviour, which has previously been correlated with endogenous oxytocin concentrations in wild seal populations. Pairs of seals that had never met previously were given intravenous injections of 0.41 µg kg −1 oxytocin or saline and were observed for 1 h post-manipulation. The dose was designed to mimic endogenous oxytocin con

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Zagrodnik, Edyta, Maciej Ziętek, Tomasz Machałowski, Barbara Dołęgowska, and Małgorzata Szczuko. "Carbetocin Is More Effective in Stabilizing Hemodynamic Parameters Compared to Oxytocin During Cesarean Section." Biomedicines 13, no. 3 (2025): 685. https://doi.org/10.3390/biomedicines13030685.

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Background/Objectives: First-line uterotonics include carbetocin and oxytocin, which act on the oxytocin receptor with varying potencies. Methods: In 70 pregnant Caucasian women who delivered by cesarean section, the effects of oxytocin and carbetocin on heart rate and blood pressure were compared. The pregnant women were divided into two groups: the OXY group, which received intravenous oxytocin 5 IU on an even day of the month, and the CARBE group, which received intravenous carbetocin 100 µg on an odd day of the month. Blood pressure and heart rate were measured noninvasively every 3 min fr

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Kiran, Bharati, Kumar Bhuvneshwar, and Bharati Sudha. "Assessing Rectal Misoprostol versus Intravenous Oxytocin in Reducing Intra and Postoperative Bleeding during Elective Cesarean Section: A Comparative Clinical Study." International Journal of Current Pharmaceutical Review and Research 16, no. 3 (2024): 244–46. https://doi.org/10.5281/zenodo.12785354.

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Aim: The aim of the present study was to compare the efficacy and safety of 400mcg misoprostol per rectumpreoperatively versus intravenous oxytocin in reducing intra operative and post-operative bleeding in electivecaesarean section.Methods: The present study included 200 women and take place in the Department of Obstetrics & Gynaecology,Government Medical College Bettiah, West Champaran, Bihar, India who were elective cases for cesareansection. Detailed history of all the patients were taken according to the performa and complete examination andall necessary investigations was done. After

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Mathe, Priyanka, Suniti Kale, Aruna Batra, Achla Batra, Shipra Aggrawal, and Abhishek Nagarajappa. "Intravenous oxytocin bolus and infusion versus infusion alone on the blood loss during caesarean section." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 12 (2019): 4824. http://dx.doi.org/10.18203/2320-1770.ijrcog20195328.

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Background: PPH is one of the leading causes of maternal mortality in the world. In India >30% maternal mortality is because of PPH.Methods: 250 females posted for LSCS were randomised into 2 groups. Group A: 5U oxytocin bolus + 40U oxytocin infusion @125 ml/hour in 500 ml saline. Group B: 5 ml Saline bolus + 40 U oxytocin infusionPrimary outcome was to measure blood loss (objective and subjective). Secondary outcomes were time for uterine hardening, additional uterotonic agents, hemodynamic changes, side effects and need for blood transfusion within 24 hours of LSCS.Results: Blood loss was

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Aabha, Verma Priya, and Hosamani Jyoti. "A Comparative Study was done on Oxytocin and Carbetocin in Order to Prevent Atonic Postpartum Hemorrhages after Repeated Elective Cesarean Sections." International Journal of Pharmaceutical and Clinical Research 15, no. 1 (2023): 434–40. https://doi.org/10.5281/zenodo.13134539.

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<strong>Background: </strong>Postpartum hemorrhage, often known as PPH, is a very dangerous illness that continues to be the primary reason for mother morbidity and death. The purpose of this study was to evaluate the efficacy of carbetocin and oxytocin as preventative agents against atonic pulmonary hypertension (PPH) in patients who were having recurrent elective cesarean sections (CS) while under the influence of spinal anesthesia. <strong>Participants and Procedures:</strong> This comparative study was performed on 100 pregnant women after 38 weeks who underwent elective ces

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Narayana, Divya, B. Pathak, Abha Khurana, and Uttara Aiyer Kohli. "Intramuscular oxytocin 10 units versus intravenous methylergometrine 0.2 mg in active management of third stage of labour for prevention of postpartum haemorrhage: a comparative study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 2 (2020): 494. http://dx.doi.org/10.18203/2320-1770.ijrcog20196072.

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Background: To compare the effectiveness of 10 IU of oxytocin IM with 0.2 mg methyl ergometrine IV in the prevention of post-partum hemorrhage when used as a part of active management of third stage of labour. This study aims to compare their influence on duration of the third stage of labour, the amount of blood loss during the third stage of labour and the immediate post-partum period and side effects of the drugs if any.Methods: The study was conducted in a tertiary care teaching hospital. 200 women, who underwent normal delivery with or without episiotomy, were enrolled and were randomly d

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Murshid, Golam, Idris Ali, Amirul Islam, et al. "Effect of oxytocin on haemodynamic change during caesarean section under spinal anaesthesia - A comparison between intravenous bolus or infusion technique." Journal of the Bangladesh Society of Anaesthesiologists 24, no. 2 (2014): 48–52. http://dx.doi.org/10.3329/jbsa.v24i2.19801.

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Background Subarachnoid block for caesarean section is very acceptable technique and it rates are steadily increasing in recent years. It is now spreading up to remote areas. Infusion technique of oxytocin is safe during caesarean section under spinal anaesthesia. Objective To compare the haemodynamic changes caused by oxytocin given as an I/V bolus or infusion to decrease uterine bleeding in caesarean section. Method A total number of sixty patients ASA grade I were selected. Thirty patient in each group. In group A, parturient received oxytocin 5IU of I/V in bolus and group B, infusion of ox

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Phillips, William J., Olga Ostrovsky, Robert L. Galli, and Sharon Dickey. "Relief of Acute Migraine Headache with Intravenous Oxytocin." Journal of Pain & Palliative Care Pharmacotherapy 20, no. 3 (2006): 25–28. http://dx.doi.org/10.1080/j354v20n03_05.

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Sarna, Mukesh C., Anil K. Soni, Martha Gomez, and Nancy E. Oriol. "Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section." Anesthesia & Analgesia 84, no. 4 (1997): 753–56. http://dx.doi.org/10.1097/00000539-199704000-00010.

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Zarzur, Edmundo. "Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section." Anesthesia & Analgesia 86, no. 6 (1998): 1334. http://dx.doi.org/10.1097/00000539-199806000-00039.

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Sarna, Mukesh C. "Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section." Anesthesia & Analgesia 86, no. 6 (1998): 1334. http://dx.doi.org/10.1097/00000539-199806000-00040.

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Zarzur, Edmundo. "Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section." Anesthesia & Analgesia 86, no. 6 (1998): 1334. http://dx.doi.org/10.1213/00000539-199806000-00039.

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Sarna, Mukesh C. "Intravenous Oxytocin in Patients Undergoing Elective Cesarean Section." Anesthesia & Analgesia 86, no. 6 (1998): 1334. http://dx.doi.org/10.1213/00000539-199806000-00040.

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