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Journal articles on the topic 'Intrinsic renal failure'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Gough, Rachel, and Kate McGovern. "Acute renal failure in adult horses." UK-Vet Equine 3, no. 6 (2019): 216–21. http://dx.doi.org/10.12968/ukve.2019.3.6.216.

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Renal disease can be pre-, intrinsic or post-renal in origin, with pre-renal disease being the most common and generally straightforward to correct if the primary problem can be addressed. Intrinsic renal disease is relatively rare in the horse overall. Nephrotoxic drugs have been thought to be the most common cause of intrinsic renal disease, but their clinical significance is now being questioned. Treatment options are usually supportive, with intravenous fluid therapy being the mainstay. Dialysis is becoming more common, although it is still a rare treatment.

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2

Sehic, Azra, and Russell W. Chesney. "Acute Renal Failure: Diagnosis." Pediatrics In Review 16, no. 3 (1995): 101–6. http://dx.doi.org/10.1542/pir.16.3.101.

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Introduction Although acute renal failure (ARF) is relatively uncommon, its mortality rate is potentially so high that it is important to recognize this condition in children. Rapid deterioration of renal function is caused by numerous insults and results in typical findings, including extracellular volume expansion, hyperkalemia, hypertension, metabolic acidosis, and azotemia. It usually is reversible, with the majority of patients recovering completely. However, ARF can lead to residual impairment of renal function and progress to end-stage renal disease and death. Conservative medical treat

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3

Mann, Henry J., David W. Fuhs, and Carl A. Hemstrom. "Acute Renal Failure." Drug Intelligence & Clinical Pharmacy 20, no. 6 (1986): 421–38. http://dx.doi.org/10.1177/106002808602000602.

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Acute renal failure (ARF) is common among critically ill patients and renal dysfunction is often associated with the multisystem organ failure syndrome. The mortality of ARF remains high but animal data indicate that prevention and early treatment may decrease the morbidity and mortality. This review defines ARF based on urine volume, laboratory parameters, and clinical presentation. The pathophysiology of prerenal, postrenal, and intrinsic ART are differentiated and diagnostic criteria provided. Preventive therapy, supportive care, and proposed treatments are outlined. Studies examining the p

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Prakash, Jai, D. Sen, N. Sarat Kumar, H. Kumar, L. K. Tripathi, and R. K. Saxena. "Acute Renal Failure Due to Intrinsic Renal Diseases: Review of 1122 Cases." Renal Failure 25, no. 2 (2003): 225–33. http://dx.doi.org/10.1081/jdi-120018723.

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5

Douglas, Sara. "Acute Tubular Necrosis: Diagnosis, Treatment, and Nursing Implications." AACN Advanced Critical Care 3, no. 3 (1992): 688–97. http://dx.doi.org/10.4037/15597768-1992-3016.

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Acute tubular necrosis (ATN) is the most common cause of acute renal failure. Early recognition of patients who are at risk for ATN can prevent or improve the course of ATN. Acute renal failure is classified as prerenal, intrinsic, or postrenal disease. ATN is classified as a type of intrinsic renal disease. The clinical course of ATN is divided into the renal failure phase, diuretic phase, and recovery phase, with each phase having distinct symptoms and laboratory findings. Diagnosis of ATN often is complicated and confusing; understanding of laboratory findings can facilitate the critical ca

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6

Worwag, Stefanie, and Cathy E. Langston. "Acute intrinsic renal failure in cats: 32 cases (1997–2004)." Journal of the American Veterinary Medical Association 232, no. 5 (2008): 728–32. http://dx.doi.org/10.2460/javma.232.5.728.

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7

Ananta, Jayaswal, Shankar Chaurasiya Om, and S. Sethi R. "Renal Dysfunction in Perinatal Asphyxia & its Correlation with Apgar Score and Hypoxic Ischemic Encephalopathy Stage." PJSR 9, no. 2 (2016): 56–60. https://doi.org/10.5281/zenodo.8244781.

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Renal involvement is frequent in perinatal asphyxia. The severity of renal involvement and adverse outcome are correlated with severity of asphyxia and HIE stage. The study determined the incidence of renal failure after perinatal asphyxia, to assess comprehensively the renal functions of asphyxiated newborns and to correlate severity and type of renal failure with Apgar Score and HIE stage. This prospective cohort study was conducted on total 50 newborns of >34wks gestational age .All neonates were evaluated clinically and their renal functions were assessed on day 3 and 5. Assessment of f

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8

MIYAHIRA ARAKAKI, Juan Manuel. "Insuficiencia renal aguda." Revista Medica Herediana 14, no. 1 (2013): 36. http://dx.doi.org/10.20453/rmh.v14i1.769.

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Acute renal failure (ARF) is a clinic syndrome characterized by decline in renal function occurring over a short time period. Is a relatively common complication in hospitalized critically ill patients and is associated with high morbidity and mortality. ARF has often a multi-factorial etiology syndrome usually approached diagnostically as pre-renal, post-renal, or intrinsic ARF. Most intrinsic ARF is caused by ischemia or nephrotoxins and is classically associated with acute tubular necrosis (ATN). High mortality is associated with severity of ARF, age more than 60 years old and presence of p

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9

Sykes, Eliot, and Joseph F. Cosgrove. "Acute Renal Failure and the Critically Ill Surgical Patient." Annals of The Royal College of Surgeons of England 89, no. 1 (2007): 22–29. http://dx.doi.org/10.1308/003588407x155536.

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Acute renal failure can occur following major surgery. Predisposing factors include massive haemorrhage, sepsis, diabetes, hypertension, cardiac disease, peripheral vascular disease, chronic renal impairment and age. Understanding epidemiology, aetiology and pathophysiology can aid effective diagnosis and management. A consensus definition for acute renal failure has recently been developed. It relates to deteriorating urine output, serum creatinine and glomerular filtration rate. In the surgical patient, precipitants are often pre-renal, although intrinsic damage and obstructed urine flow can

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10

Kwon, Eunji, Ji Mi Jung, and Chung Woo Yeung. "Clinical Analysis of Acute Intrinsic Renal Failure in Neonates and Children." Journal of the Korean Society of Pediatric Nephrology 12, no. 1 (2008): 30. http://dx.doi.org/10.3339/jkspn.2008.12.1.30.

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11

Seibert, Felix S., Christian Rosenberger, Susanne Mathia, et al. "Urinary Calprotectin Differentiates Between Prerenal and Intrinsic Acute Renal Allograft Failure." Transplantation 101, no. 2 (2017): 387–94. http://dx.doi.org/10.1097/tp.0000000000001124.

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12

César, Bruno Nogueira, and Marcelino de Souza Durão Júnior. "Acute kidney injury in cancer patients." Revista da Associação Médica Brasileira 66, suppl 1 (2020): s25—s30. http://dx.doi.org/10.1590/1806-9282.66.s1.25.

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SUMMARY The increasing prevalence of neoplasias is associated with new clinical challenges, one of which is acute kidney injury (AKI). In addition to possibly constituting a clinical emergency, kidney failure significantly interferes with the choice and continuation of antineoplastic therapy, with prognostic implications in cancer patients. Some types of neoplasia are more susceptible to AKI, such as multiple myeloma and renal carcinoma. In cancer patients, AKI can be divided into pre-renal, renal (intrinsic), and post-renal. Conventional platinum-based chemotherapy and new targeted therapy ag

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13

Wei, Qingqing, Xiao-Ming Yin, Mong-Heng Wang, and Zheng Dong. "Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice." American Journal of Physiology-Renal Physiology 290, no. 1 (2006): F35—F42. http://dx.doi.org/10.1152/ajprenal.00184.2005.

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Tubular cell apoptosis is involved in ischemic renal failure, but the underlying mechanism is unclear. Bid, a proapoptotic Bcl-2 family protein, may regulate the intrinsic as well as the extrinsic pathway of apoptosis. In vivo, Bid is most abundantly expressed in the kidneys. However, the role played by Bid in renal pathophysiology is unknown. Our recent work demonstrated Bid activation during renal ischemia-reperfusion. The current study has determined the role of Bid in ischemic renal injury and renal failure using Bid-deficient mice. In wild-type C57BL/6 mice, Bid was proteolytically proces

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14

Singer, Eugenia, Antje Elger, Saban Elitok, et al. "Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes." Kidney International 80, no. 4 (2011): 405–14. http://dx.doi.org/10.1038/ki.2011.41.

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15

Palmer, T. Norman, Margaret A. Caldecourt, Savita Gossain, Sheila Mangat, and C. Sugden. "Impaired muscle glucose metabolism in acute renal failure." Bioscience Reports 5, no. 5 (1985): 433–38. http://dx.doi.org/10.1007/bf01116561.

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Renal failure is associated with peripheral insulin resistance and consequent carbohydrate intolerance. This report investigates carbohydrate metabolism in vitro in epitrochlearis and hemidiaphragm muscles taken from acutely uraemic and sham-operated rats. Muscles from acutely uraemic rats (compared to those from sham-operated rats) incubated with 5 mM glucose showed increased rates of basal and insulin-stimulated glycolysis and glycogen turnover, but pyruvate dehydro-genase and tricarboxylic acid – cycle flux was not increased in uraemia. Glycolysis (but not glycogen turnover) in muscles from

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16

Cosentini, Deborah, Salvatore Grisanti, Alberto Dalla Volta, et al. "Immunotherapy failure in adrenocortical cancer: where next?" Endocrine Connections 7, no. 12 (2018): E5—E8. http://dx.doi.org/10.1530/ec-18-0398.

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Immunotherapy is widely used in the treatment of different cancer types, including metastatic melanoma, non-small cell lung cancer, renal cell carcinoma and urothelial cancer. The results of the phase I JAVELIN study failed to demonstrate a substantial activity of the PDL-1 inhibitor Avelumab in advanced adrenocortical carcinoma (ACC). This editorial focus on the possible mechanisms of ACC immunoevasion and suggests strategies to overcome the intrinsic immunotherapy resistance of this disease.

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17

Anton Sagayanathan, Prasanth, Xin Yi Goai, Ajanthan Loganathan, and Simon Pridgeon. "Intrinsic ureteric obstruction secondary to endometriosis: a rare clinical entity causing obstructive uropathy and renal failure." BMJ Case Reports 17, no. 2 (2024): e258026. http://dx.doi.org/10.1136/bcr-2023-258026.

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Ureteral endometriosis is rare and can be a silent clinical entity, which can potentially lead to serious complications such as obstructive uropathy, sepsis and renal failure. A high clinical suspicion is required especially in childbearing age groups due to non-specific presentation such as renal colic, recurrent urinary tract infection (UTI), renal failure or asymptomatic hydronephrosis.A woman in her 40s presented with febrile UTI and flank pain. She reportedly suffered from recurrent UTIs in the past. Initial workup revealed an infected, obstructed left renal collecting system with gross h

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18

Shalmi, C. L., J. P. Dutcher, D. A. Feinfeld, et al. "Acute renal dysfunction during interleukin-2 treatment: suggestion of an intrinsic renal lesion." Journal of Clinical Oncology 8, no. 11 (1990): 1839–46. http://dx.doi.org/10.1200/jco.1990.8.11.1839.

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Adoptive immunotherapy with interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells has been effective in treating some advanced malignancies in animals and humans. One complication of this treatment is a reversible, oliguric, acute renal failure, which has been ascribed to renal hypoperfusion and resultant prerenal azotemia. We serially studied renal function in 10 patients receiving high-dose regimens of recombinant interleukin-2 (rIL-2) to attempt to delineate further the nature of the renal dysfunction caused by IL-2 treatment. Renal plasma flow was computed from iodine 131 (I-131

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19

Power, D. A., J. Haughney, A. J. Nicholls, et al. "Acute Renal Failure: The Tip of the Iceberg?" Scottish Medical Journal 30, no. 1 (1985): 19–22. http://dx.doi.org/10.1177/003693308503000104.

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This study reports the experience, during a six-year period, of the Aberdeen Renal Unit in the treatment of patients with acute renal failure. The combination of a relatively stable population base and a single regional dialysis centre has allowed the incidence of acute renal failure to be assessed. Approximately 30 patients per million population were dialysed annually for acute renal failure; 69 per cent of these patients (20.5 per million population per year) were dialysed for acute reversible intrinsic renal failure (ARIRF) and mortality in this group was 44 per cent. Patients with more se

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20

Sancho-Martínez, Sandra M., Alfredo G. Casanova, Annette G. Düwel, et al. "Identification of Pre-Renal and Intrinsic Acute Kidney Injury by Anamnestic and Biochemical Criteria: Distinct Association with Urinary Injury Biomarkers." International Journal of Molecular Sciences 24, no. 3 (2023): 1826. http://dx.doi.org/10.3390/ijms24031826.

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Acute kidney injury (AKI) is a syndrome of sudden renal excretory dysfunction with severe health consequences. AKI etiology influences prognosis, with pre-renal showing a more favorable evolution than intrinsic AKI. Because the international diagnostic criteria (i.e., based on plasma creatinine) provide no etiological distinction, anamnestic and additional biochemical criteria complement AKI diagnosis. Traditional, etiology-defining biochemical parameters, including the fractional excretion of sodium, the urinary-to-plasma creatinine ratio and the renal failure index are individually limited b

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21

Bishu, Kalkidan, James Arnold, and Inder S. Anand. "Worsening Renal Function in Acute Decompensated Congestive Heart Failure: A Function of Intrinsic Renal Disease or Hemodynamic Alteration with Heart Failure Treatment?" Journal of Cardiac Failure 13, no. 6 (2007): S171. http://dx.doi.org/10.1016/j.cardfail.2007.06.605.

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22

Choopa, M. S., and G. Van Biljon. "Acute kidney injury in children – not just for the nephrologist." South African Family Practice 57, no. 6 (2015): 4. http://dx.doi.org/10.4102/safp.v57i6.4376.

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Acute kidney injury (AKI) is a condition that is characterised by an abrupt reduction in kidney function, and is not limited to acute renal failure. However, it is potentially treatable. Failure to do so may result in death or progression to chronic kidney disease (CKD). AKI requires urgent management in order to ensure a better clinical outcome. Traditionally, AKI is classified according to aetiology, i.e. pre-renal, intrinsic renal and post-renal AKI. Clinical features depend on the age of the patient, the cause and related complications. Symptoms and signs may be non-specific, e.g. poor fee

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23

Fareed, Gande Apoorva, Lakshmi Himaja, Rashmi Rithika, and VL Shanthan Dr. "Assessment of rifle criteria for acute kidney injury patients in tertiary care teaching hospital." International Journal of Scientific Development and Research 9, no. 2 (2024): 511–16. https://doi.org/10.5281/zenodo.11241884.

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Acute kidney injury (AKI) is a common and serious complication in critically ill patients. It is frequently caused by insufficient renal perfusion as a result of severe trauma, sickness, or surgery, but it can also be caused by a quickly advancing, intrinsic renal disease. Acute kidney injury (AKI) affects 3–7 % of patients admitted to the hospital and approximately  25–30 % of patients in the intensive care unit. The widespread use of RIFLE and classification system for acute kidney injury (AKI) diagnosis and staging have established the association between AKI severity and a

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24

Shah, Syed Raza, Sameer Altaf Tunio, Mohammad Hussham Arshad, et al. "Acute Kidney Injury Recognition and Management: A Review of the Literature and Current Evidence." Global Journal of Health Science 8, no. 5 (2015): 120. http://dx.doi.org/10.5539/gjhs.v8n5p120.

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<p>Acute renal failure is defined as a rapid decrease in the glomerular filtration rate, occurring over a period of hours to days and by the inability of the kidney to regulate fluid and electrolyte homeostasis appropriately. AKI is a catastrophic, life-threatening event in critically ill patients. AKI can be divided into pre-renal injury, intrinsic kidney disease (including vascular insults) and obstructive uropathies. The prognosis of AKI is highly dependent on the underlying cause of the injury. Children who have AKI as a component of multisystem failure have a much higher mortality r

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25

Puig, J., M. Vilafranca, A. Font, J. Closa, M. Pumarola, and J. Mascort. "Acute intrinsic renal failure and blood coagulation disorders after a snakebite in a dog." Journal of Small Animal Practice 36, no. 7 (1995): 333–36. http://dx.doi.org/10.1111/j.1748-5827.1995.tb02942.x.

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26

Maund, Victoria. "Care of the acute kidney injury patient." Companion Animal 28, no. 10 (2023): 2–7. http://dx.doi.org/10.12968/coan.2023.0022.

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Acute kidney injury, previously called acute renal failure, indicates a sudden and often reversible reduction in kidney function as measured by glomerular filtration rate, increased serum and plasma creatinine concentration and changes in urine output. This article reviews the pathophysiology and common causes of acute kidney injuries, including pre-renal causes from hypovolaemia, intrinsic renal causes such as glomerular diseases and post-renal obstructive causes. Veterinary nurses should be aware of the common diagnostic tests used and how to deliver support to the hospitalised patient. Whil

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Maund, Victoria. "Care of the acute kidney injury patient." Veterinary Nurse 14, no. 8 (2023): 344–50. http://dx.doi.org/10.12968/vetn.2023.14.8.344.

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Acute kidney injury, previously called acute renal failure, indicates a sudden and often reversible reduction in kidney function as measured by glomerular filtration rate, increased serum and plasma creatinine concentration and changes in urine output. This article reviews the pathophysiology and common causes of acute kidney injuries, including pre-renal causes from hypovolaemia, intrinsic renal causes such as glomerular diseases and post-renal obstructive causes. Veterinary nurses should be aware of the common diagnostic tests used and how to deliver support to the hospitalised patient. Whil

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28

Dr.Venugopal, Reddy.I, and Mogali Dr.Santosh. "Acute Renal Failure in Neonates:Clinical and Laboratory Profile." International Journal of Innovative Science and Research Technology 8, no. 4 (2023): 997–1007. https://doi.org/10.5281/zenodo.7885055.

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Pre-renal failure is the most common cause of neonatal acute renal failure (ARF), which is a significant disruption of glomerular filtration and tubular function in infants. It is brought on by intra-abdominal compartment syndrome, decreased effective blood volume, increased capillary leak, inadequate cardiac output, and renal hypoperfusion. Renal failure is a major problem that results in co-morbidities and a prolonged hospital stay in neonates who have been asphyxiated. According to the National Neonatal Perinatal Database of India, 2003, 2.5% of intramural deliveries required bag and mask v

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29

Miklovic, Matus, Olga Gawrys, Zuzana Honetschlagerova, et al. "Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model." Hypertension research 47, no. 10 (2024): 2718–30. https://doi.org/10.1038/s41440-024-01580-3.

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Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable by a decrease in vascular afterload, or diminished neurohumoral response in the kidneys, or whether RDN procedure per se has direct myocardial effects in the failing heart. To elucidate mechanisms how RDN affects failing heart, we studied load-independent indexes of ventricular function, gene markers of myocardial remodeling, and cardiac sympathetic signaling in HF, indu

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El-Reshaid, Kamel, and Shaikha Al-Bader. "Acute Renal Injury: Revisited." Journal of Drug Delivery and Therapeutics 10, no. 4 (2020): 221–24. http://dx.doi.org/10.22270/jddt.v10i4.4154.

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Acute kidney injury (AKI) indicates its abrupt deterioration and is defined as an increase in serum creatinine more than the baseline by > 26 umol/L within 48 hours or > 50% within 1 week. The latter since glomerular failure is the life-threatening one with: (a) uremic intoxication, (b) water and salt retention with fluid overload, and (c) potassium accumulation with cardiac arrest. The etiology can be pre-renal, post-renal or intrinsic. Diagnosis is established by history of new insults, physical examination for hydration status, systemic stability and manifestations of autoimmune disea

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31

Sheybani-Deloui, Sepideh, Lijun Chi, Marian V. Staite, et al. "Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction." Journal of the American Society of Nephrology 29, no. 2 (2017): 532–44. http://dx.doi.org/10.1681/asn.2017050482.

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Intrinsic ureteropelvic junction obstruction is the most common cause of congenital hydronephrosis, yet the underlying pathogenesis is undefined. Hedgehog proteins control morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation of the GLI3 transcriptional repressor. Hedgehog regulates differentiation and proliferation of ureteric smooth muscle progenitor cells during murine kidney-ureter development. Histopathologic findings of smooth muscle cell hypertrophy and stroma-like cells, consistently observed in obstructing tissue at the time of surgical corre

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32

Conjard, A., B. Ferrier, M. Martin, A. Caillette, H. Carrier, and G. Baverel. "Effects of chronic renal failure on enzymes of energy metabolism in individual human muscle fibers." Journal of the American Society of Nephrology 6, no. 1 (1995): 68–74. http://dx.doi.org/10.1681/asn.v6168.

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In order to improve knowledge about the mechanisms underlying the alterations of energy metabolism recently observed in the skeletal muscle of patients suffering from chronic renal failure, this study was designed to test (1) whether changes in the activity of key enzymes of energy metabolism occur in the muscle of these patients, and if so (2) whether the different muscle fiber types are equally altered in their metabolic machinery. For this, the maximum activities of 14 enzymes were measured in individual muscle fibers microdissected from biopsies of rectus abdominis muscle obtained from sev

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Gawaz, M. P., G. Dobos, M. Späth, P. Schollmeyer, H. J. Gurland, and S. K. Mujais. "Impaired function of platelet membrane glycoprotein IIb-IIIa in end-stage renal disease." Journal of the American Society of Nephrology 5, no. 1 (1994): 36–46. http://dx.doi.org/10.1681/asn.v5136.

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Impaired platelet function and a bleeding tendency are well-recognized complications of chronic renal failure. Because the fibrinogen receptor GPIIb-IIIa plays a central role in platelet aggregation and adhesion to the subendothelium, it was reasoned that a defect in this receptor may underlie the impaired platelet function in uremia. To test this hypothesis, the function of this receptor in the platelets of 11 uremic patients was studied. Aggregation studies were performed with flow cytometric techniques with anti-GPIIb-IIIa conformation-specific monoclonal antibodies (mAb) (anti-LIBS1 and an

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Torres, Natalie, L. Walker, Jaylyn Waddell, Adnan Bhutta, Jason Custer, and Dayanand Bagdure. "Extracorporeal Membrane Oxygenation for Neonates with Congenital Renal and Urological Anomalies and Pulmonary Hypoplasia: A Case Report and Review of the Extracorporeal Life Support Organization Registry." Journal of Pediatric Intensive Care 06, no. 03 (2017): 188–93. http://dx.doi.org/10.1055/s-0037-1598036.

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Objective Congenital anomalies of the kidney and urinary tract constitute up to 30% of anomalies identified in the neonatal period. In utero oligohydramnios is often associated with pulmonary hypoplasia and respiratory failure in the neonate who may not be responsive to mechanical ventilation. Placement of these neonates on extracorporeal membrane oxygenation (ECMO) remains controversial and is considered in most centers to be a relative contraindication. The objective of this study is to use the Extracorporeal Life Support Organization (ELSO) database to describe the outcomes and complication

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Solà, Elsa, and Pere Ginès. "Challenges and Management of Liver Cirrhosis: Pathophysiology of Renal Dysfunction in Cirrhosis." Digestive Diseases 33, no. 4 (2015): 534–38. http://dx.doi.org/10.1159/000375344.

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Kidney dysfunction is a common complication of patients with advanced cirrhosis and is associated with poor prognosis. Patients with advanced cirrhosis show circulatory dysfunction characterized by reduced systemic vascular resistance due to splanchnic arterial vasodilation, which is caused by portal hypertension. The progressive reduction in systemic vascular resistance leads to effective arterial hypovolemia. In order to maintain arterial pressure within normal limits in this setting, there is activation of systemic vasoconstrictor systems, including the renin-angiotensin-aldosterone system,

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36

Suillot, Joelle, Jürg Bollmann, Samuel Rotman, and Eric Descombes. "Bilateral Ureteral Stenosis with Hydronephrosis as First Manifestation of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis): A Case Report and Review of the Literature." Case Reports in Nephrology 2020 (December 21, 2020): 1–6. http://dx.doi.org/10.1155/2020/7189497.

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Ureteral stenosis is a rare manifestation of granulomatosis with polyangiitis (formerly known as Wegener’s granulomatosis). We report the case of a 76-year-old woman with progressive renal failure in which bilateral hydronephrosis due to ureteral stenosis was the first manifestation of the disease. Our patient also had renal involvement with pauci-immune crescentic glomerulonephritis associated with high titers of anti-proteinase 3 c-ANCAs, but no involvement of the upper or lower respiratory tract. The hydronephrosis and renal function rapidly improved under immunosuppressive therapy with hig

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Molina Barragan, Antoine-Marie, Emmanuel Pardo, Pierre Galichon, et al. "SARS-CoV-2 Renal Impairment in Critical Care: An Observational Study of 42 Cases (Kidney COVID)." Journal of Clinical Medicine 10, no. 8 (2021): 1571. http://dx.doi.org/10.3390/jcm10081571.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to 5% to 16% hospitalization in intensive care units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI). The current work aims to precisely characterize the renal impairment associated to SARS-CoV-2 in ICU patients. Forty-two patients consecutively admitted to the ICU of a French university hospital who tested positive for SARS-CoV-2 between 25 March 2020, and 29 April 2020, were included and classified in categories according to their renal function. Complete renal

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Abbas, Rabeea, Tabassum Elahi, Shumaila Manan, and Shafique Younas. "The aetiology, risk factors and outcome of acute kidney injury in patients requiring kidney replacement therapy – a prospective single center experience." Journal of the Pakistan Medical Association 74, no. 1 (2023): 94–98. http://dx.doi.org/10.47391/jpma.10985.

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Objective: To find out the causes, associated leading factors and impact of kidney replacement therapy on patients hospitalised for acute kidney injury in a tertiary care setting. Method: The prospective, cross-sectional study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from January 1 to March 31, 2022, and comprised patients of either gender aged 18 or more years presenting with acute kidney injury as per the Kidney Disease Improving Global Outcomes criteria and required kidney replacement therapy. Complete, partial or no recovery was the main outcome paramet

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Annema, Wijtske, Jan Freark de Boer, Arne Dikkers, et al. "Group IIA Secretory Phospholipase A2 Predicts Graft Failure and Mortality in Renal Transplant Recipients by Mediating Decreased Kidney Function." Journal of Clinical Medicine 9, no. 5 (2020): 1282. http://dx.doi.org/10.3390/jcm9051282.

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The acute phase protein group IIA secretory phospholipase A2 (sPLA2-IIA) has intrinsic proatherosclerotic properties. The present prospective cohort study investigated whether plasma sPLA2-IIA associates with graft failure, cardiovascular, and all-cause mortality in renal transplant recipients (RTRs), patients with accelerated atherosclerosis formation both systemically and within the graft. In 511 RTRs from a single academic center with stable graft function >1 year, baseline plasma sPLA2-IIA was determined by ELISA. Primary end points were death-censored graft failure and mortality (media

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Slon Roblero, Maria Fernanda, Natalie Borman, and Maria Auxiliadora Bajo Rubio. "Integrated care: enhancing transition from renal replacement therapy options to home haemodialysis." Clinical Kidney Journal 13, no. 1 (2019): 105–10. http://dx.doi.org/10.1093/ckj/sfz140.

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Abstract Transition is an intrinsic process in the life of a patient with kidney disease and should be planned and anticipated when possible. A single therapy option might not be adequate across a patient’s entire lifespan and many patients will require a switch in their treatment modality to adapt the treatment to their clinical and psychosocial needs. There are several reasons behind changing a patient’s treatment modality, and the consequences of each decision should be evaluated, considering both short- and long-term benefits and risks. Dialysis modality transition is not only to allow for

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Hameed, Imran. "Variability: The Hallmark of Blood Pressure Measurement – Types, Assessment and Prognostic Significance." Pakistan Heart Journal 56, no. 3 (2023): 195–204. http://dx.doi.org/10.47144/phj.v56i3.2617.

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Systemic blood pressure, recorded by various parameters, always shows variation. This is known as ‘variability’, an entity not assessed routinely. Research has shown greater prognostic importance of it than routine parameters. Various intrinsic and extrinsic factors modulate it. Depending on the interval of successive readings, blood pressure variability is of five types, with different non-invasive methods utilized for recording. It is calculated by various statistical parameters, the most common being standard deviation, but average real variability is the most accurate and easily applied. C

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Bronisz, Marek, Danuta Rość, Agata Bronisz, Jacek Manitius, and Edmund Nartowicz. "The Role of Intrinsic Fibrinolytic System Activation in Pathogenesis of Hemostasis Disturbances in Hemodialized Patients with Chronic Renal Failure." Renal Failure 26, no. 3 (2004): 223–29. http://dx.doi.org/10.1081/jdi-120039519.

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Krishnamurthy, G., Vijay Kher, and Sita Naik. "Low Response to HBsAg Vaccine in Chronic Renal Failure Patients is not due to Intrinsic Defect of B Cells." Scandinavian Journal of Urology and Nephrology 36, no. 5 (2002): 377–82. http://dx.doi.org/10.1080/003655902320783908.

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Maeshima, Akito, Masao Nakasatomi, and Yoshihisa Nojima. "Regenerative Medicine for the Kidney: Renotropic Factors, Renal Stem/Progenitor Cells, and Stem Cell Therapy." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/595493.

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The kidney has the capacity for regeneration and repair after a variety of insults. Over the past few decades, factors that promote repair of the injured kidney have been extensively investigated. By using kidney injury animal models, the role of intrinsic and extrinsic growth factors, transcription factors, and extracellular matrix in this process has been examined. The identification of renal stem cells in the adult kidney as well as in the embryonic kidney is an active area of research. Cell populations expressing putative stem cell markers or possessing stem cell properties have been found

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Gräsbeck, R. "Selective cobalamin malabsorption and the cobalamin-intrinsic factor receptor." Acta Biochimica Polonica 44, no. 4 (1997): 725–33. http://dx.doi.org/10.18388/abp.1997_4374.

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The disease is characterised by cobalamin (Cbl) deficiency in children 0-5 years old, causing failure to thrive, infections, megaloblastic anaemia, neuropathy, and mild general malabsorption; slight proteinuria is common. Cbl injections produce remission, but Cbl malabsorption and proteinuria persist. About 250 cases have been reported. Dogs also have it. The heredity is autosomal and recessive. The physiological and pathological absorption mechanisms are described: Cbl liberated from food by digestion is first bound to haptocorrin, but in the intestine it is transferred to intrinsic factor. I

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Gatzoflias, Stergios, Shoujin Hao та Nicholas R. Ferreri. "Induction of renal tumor necrosis factor-α and other autacoids and the beneficial effects of hypertonic saline in acute decompensated heart failure". American Journal of Physiology-Renal Physiology 320, № 6 (2021): F1159—F1164. http://dx.doi.org/10.1152/ajprenal.00686.2020.

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Although administration of hypertonic saline (HSS) in combination with diuretics has yielded improved weight loss, preservation of renal function, and reduction in hospitalization time in the clinical setting of patients with acute decompensated heart failure (ADHF), the mechanisms that underlie these beneficial effects remain unclear and additional studies are needed before this approach can be adopted on a more consistent basis. As high salt conditions stimulate the production of several renal autacoids that exhibit natriuretic effects, renal physiologists can contribute to the understanding

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Floras, John S. "The 2021 Carl Ludwig Lecture. Unsympathetic autonomic regulation in heart failure: patient-inspired insights." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321, no. 3 (2021): R338—R351. http://dx.doi.org/10.1152/ajpregu.00143.2021.

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Defined as a structural or functional cardiac abnormality accompanied by symptoms, signs, or biomarkers of altered ventricular pressures or volumes, heart failure also is a state of autonomic disequilibrium. A large body of evidence affirms that autonomic disturbances are intrinsic to heart failure; basal or stimulated sympathetic nerve firing or neural norepinephrine (NE) release more often than not exceed homeostatic need, such that an initially adaptive adrenergic or vagal reflex response becomes maladaptive. The magnitude of such maladaptation predicts prognosis. This Ludwig lecture develo

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Cowley, B. D., L. J. Chadwick, J. J. Grantham, and J. P. Calvet. "Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse." Journal of the American Society of Nephrology 1, no. 8 (1991): 1048–53. http://dx.doi.org/10.1681/asn.v181048.

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Polycystic kidney disease in the C57BL/6J (cpk) mouse is an autosomal recessive disorder which leads to the rapid development of renal cysts and kidney failure during the first 3 to 4 postnatal weeks. Previously, we showed that the cystic kidneys of affected mice have abnormally elevated levels of c-myc mRNA. In the study presented here, it is shown that mRNAs for the proto-oncogenes c-fos and c-Kiras, as well as c-myc, are markedly elevated in cystic kidneys, suggesting that there is a more general abnormality in gene expression associated with the disease. It is also evident that there are t

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Pazarci, Percin, Serkan Özler, and Halil Mahir Kaplan. "Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney." PeerJ 12 (October 18, 2024): e18335. http://dx.doi.org/10.7717/peerj.18335.

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Aminoglycoside nephrotoxicity stands as a primary contributor to the development of acute intrinsic renal failure. Distinctive characteristic associated with this nephrotoxicity is the occurrence of tubular necrosis, which is why it is commonly referred to as acute tubular necrosis. Studies have demonstrated that inhibiting rhoA/rho-kinase pathway is beneficial for kidney damage induced by diabetes and renal ischemia. Comparable pathological conditions can be observed in aminoglycoside nephrotoxicity, like those found in diabetes and renal ischemia. Gentamicin, an aminoglycoside, is known to a

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Kumari, Seema, Chandra Mukul Manish, and Singh B.P. "A Clinical-Epidemiological Assessment of Individuals with Acute Renal Damage." International Journal of Current Pharmaceutical Review and Research 15, no. 12 (2023): 944–48. https://doi.org/10.5281/zenodo.13253876.

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AbstractAim: To examine the clinical characteristics and range of causes in individuals with acute renal damage at atertiary care hospital.Material and Methods: This study was conducted in the Department of Medicine, IGIMS, Patna, Bihar, Indiafor 10 months. The study was a retrospective study, with 170 patients to characterize Acute Kidney Injury, definedby KDIGO classification. Patients with Increase in serum creatinine by ≥0.3mg/dl (≥26.5µmol/l) within 48hours.Increase in serum creatinine to ≥1.5 time’s baseline which is known or presumed to have occurred within theprevi

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