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1
Xue, Liting. "Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/740.
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The CBFbeta-SMMHC fusion protein is expressed in acute myeloid leukemia (AML) samples with the chromosome inversion inv(16)(p13;q22). This fusion protein binds the transcription factor RUNX with higher affinity than its physiological partner CBFbeta and disrupts the core binding factor (CBF) activity in hematopoietic stem and progenitor cells. Studies in the Castilla laboratory have shown that CBFbeta-SMMHC expression blocks differentiation of hematopoietic progenitors, creating a pre-leukemic progenitor that progresses to AML in cooperation with other mutations. However, the combined function of cumulative cooperating mutations in the pre-leukemic progenitor cells that enhance their expansion to induce leukemia is not known. The standard treatment for inv(16) AML is based on the use of non-selective cytotoxic chemotherapy, resulting in a good initial response, but with limited long-term survival. Therefore, there is a need for developing targeted therapies with improved efficacy in leukemic cells and minimal toxicity for normal cells.
Here, we used conditional Nras+/LSL-G12D; Cbfb+/56M; Mx1Cre knock-in mice to show that allelic expression of oncogenic N-RasG12D expanded the multi-potential progenitor (MPP) compartment by 8 fold. Allelic expression of Cbfbeta-SMMHC increased the MPPs and short-term hematopoietic stem cells (ST-HSCs) by 2 to 4 fold both alone and in combination with N-RasG12D expression. In addition, allelic expression of oncogenic N-RasG12D and Cbfbeta-SMMHC increases survival of pre-leukemic stem and progenitor cells. Differential analysis of bone marrow cells determined that Cbfb+/MYH11 and Nras+/G12D; vii Cbfb+/MYH11 cells included increased number of blasts, myeloblasts and promyelocytes and a reduction in immature granulocytes, suggesting that expression of N-RasG12D cannot bypass Cbfbeta-SMMHC driven differentiation block.
N-RasG12D and Cbfbeta-SMMHC synergized in leukemia, in which Nras+/G12D; Cbfb+/MYH11 mice have a shorter median latency than Cbfb+/MYH11 mice. In addition, the synergy in leukemogenesis was cell autonomous. Notably, leukemic cells expressing N-RasG12D and Cbfbeta-SMMHC showed higher (over 100 fold) leukemia-initiating cell activity in vivo than leukemic cells expressing Cbfbeta-SMMHC (L-IC activity of 1/4,000 and 1/528,334, respectively).
Short term culture and biochemical assays revealed that pre-leukemic and leukemic cells expressing N-RasG12D and Cbfbeta-SMMHC have reduced levels of pro-apoptotic protein Bim compared to control. The Nras+/G12D; CbfbMYH11 pre-leukemic and leukemic cells were sensitive to pharmacologic inhibition of MEK/ERK signaling pathway with increasing apoptosis and Bim protein levels but not sensitive to PI3K inhibitors. In addition, knock-down of Bcl2l11 (Bim) expression in Cbfbeta-SMMHC pre-leukemic progenitors decreased their apoptosis levels.
In collaboration with Dr. John Bushweller’s and other research laboratories, we recently developed a CBFbeta-SMMHC inhibitor named AI-10-49, which specifically binds to CBFbeta-SMMHC, prevents its binding to RUNX proteins and restores CBF function. Biochemical analysis in human leukemic cells showed that AI-10-49 has significant specificity in reducing the viability of leukemic cells expressing CBFbeta-SMMHC (IC50= 0.83μM), and negligible toxicity in normal cells. Likewise, mouse Nras+/G12D; viii Cbfb+/MYH11 leukemic cells were sensitive to AI-10-49 (IC50= 0.93μM). By using the NrasLSL-G12D; Cbfb56M mouse model, we also show that AI-10-49 significantly prolongs the survival of mice bearing the leukemic cells. Preliminary mechanistic analysis of AI-10-49 activity has shown that AI-10-49 increased BCL2L11 transcript levels in a dose and time dependent manner in murine and human leukemic cells, suggesting that the viability through BIM-mediated apoptosis may be targeted by both oncogenic signals.
My thesis study demonstrates that Cbfbeta-SMMHC and N-RasG12D promote the survival of pre-leukemic myeloid progenitors primed for leukemia by activation of the MEK/ERK/Bim axis, and define NrasLSL-G12D; Cbfb56M mice as a valuable genetic model for the study of inv(16) AML targeted therapies. For instance, the novel CBFbeta-SMMHC inhibitor AI-10-49 shows a significant efficacy in this mouse model. This small molecule will serve as a promising first generation drug for targeted therapy of inv(16) leukemia and also a very useful tool to understand mechanisms of leukemogenesis driving by CBFbeta-SMMHC.
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Xue, Liting. "Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/740.
Full textAbstract:
The CBFbeta-SMMHC fusion protein is expressed in acute myeloid leukemia (AML) samples with the chromosome inversion inv(16)(p13;q22). This fusion protein binds the transcription factor RUNX with higher affinity than its physiological partner CBFbeta and disrupts the core binding factor (CBF) activity in hematopoietic stem and progenitor cells. Studies in the Castilla laboratory have shown that CBFbeta-SMMHC expression blocks differentiation of hematopoietic progenitors, creating a pre-leukemic progenitor that progresses to AML in cooperation with other mutations. However, the combined function of cumulative cooperating mutations in the pre-leukemic progenitor cells that enhance their expansion to induce leukemia is not known. The standard treatment for inv(16) AML is based on the use of non-selective cytotoxic chemotherapy, resulting in a good initial response, but with limited long-term survival. Therefore, there is a need for developing targeted therapies with improved efficacy in leukemic cells and minimal toxicity for normal cells.
Here, we used conditional Nras+/LSL-G12D; Cbfb+/56M; Mx1Cre knock-in mice to show that allelic expression of oncogenic N-RasG12D expanded the multi-potential progenitor (MPP) compartment by 8 fold. Allelic expression of Cbfbeta-SMMHC increased the MPPs and short-term hematopoietic stem cells (ST-HSCs) by 2 to 4 fold both alone and in combination with N-RasG12D expression. In addition, allelic expression of oncogenic N-RasG12D and Cbfbeta-SMMHC increases survival of pre-leukemic stem and progenitor cells. Differential analysis of bone marrow cells determined that Cbfb+/MYH11 and Nras+/G12D; vii Cbfb+/MYH11 cells included increased number of blasts, myeloblasts and promyelocytes and a reduction in immature granulocytes, suggesting that expression of N-RasG12D cannot bypass Cbfbeta-SMMHC driven differentiation block.
N-RasG12D and Cbfbeta-SMMHC synergized in leukemia, in which Nras+/G12D; Cbfb+/MYH11 mice have a shorter median latency than Cbfb+/MYH11 mice. In addition, the synergy in leukemogenesis was cell autonomous. Notably, leukemic cells expressing N-RasG12D and Cbfbeta-SMMHC showed higher (over 100 fold) leukemia-initiating cell activity in vivo than leukemic cells expressing Cbfbeta-SMMHC (L-IC activity of 1/4,000 and 1/528,334, respectively).
Short term culture and biochemical assays revealed that pre-leukemic and leukemic cells expressing N-RasG12D and Cbfbeta-SMMHC have reduced levels of pro-apoptotic protein Bim compared to control. The Nras+/G12D; CbfbMYH11 pre-leukemic and leukemic cells were sensitive to pharmacologic inhibition of MEK/ERK signaling pathway with increasing apoptosis and Bim protein levels but not sensitive to PI3K inhibitors. In addition, knock-down of Bcl2l11 (Bim) expression in Cbfbeta-SMMHC pre-leukemic progenitors decreased their apoptosis levels.
In collaboration with Dr. John Bushweller’s and other research laboratories, we recently developed a CBFbeta-SMMHC inhibitor named AI-10-49, which specifically binds to CBFbeta-SMMHC, prevents its binding to RUNX proteins and restores CBF function. Biochemical analysis in human leukemic cells showed that AI-10-49 has significant specificity in reducing the viability of leukemic cells expressing CBFbeta-SMMHC (IC50= 0.83μM), and negligible toxicity in normal cells. Likewise, mouse Nras+/G12D; viii Cbfb+/MYH11 leukemic cells were sensitive to AI-10-49 (IC50= 0.93μM). By using the NrasLSL-G12D; Cbfb56M mouse model, we also show that AI-10-49 significantly prolongs the survival of mice bearing the leukemic cells. Preliminary mechanistic analysis of AI-10-49 activity has shown that AI-10-49 increased BCL2L11 transcript levels in a dose and time dependent manner in murine and human leukemic cells, suggesting that the viability through BIM-mediated apoptosis may be targeted by both oncogenic signals.
My thesis study demonstrates that Cbfbeta-SMMHC and N-RasG12D promote the survival of pre-leukemic myeloid progenitors primed for leukemia by activation of the MEK/ERK/Bim axis, and define NrasLSL-G12D; Cbfb56M mice as a valuable genetic model for the study of inv(16) AML targeted therapies. For instance, the novel CBFbeta-SMMHC inhibitor AI-10-49 shows a significant efficacy in this mouse model. This small molecule will serve as a promising first generation drug for targeted therapy of inv(16) leukemia and also a very useful tool to understand mechanisms of leukemogenesis driving by CBFbeta-SMMHC.
3
Kuss, Bryone Jean. "Molecular and gene expression studies of the genes involved in the breakpoints of the inv(16) leukaemias." Title page, abstract and contents only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phk972.pdf.
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Quesnel, Bruno. "Les leucemies aigues induites a caryotype t (8;21) inv (16,) t (8;16) : une nouvelle forme de leucemie aigue induite ?" Lille 2, 1994. http://www.theses.fr/1994LIL2M180.
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Du, Juan. "RAS, KIT, FLT3 and JAK2 gene mutations in Acute Myeloid Leukemia (AML) with inv(16) and t(8;21): Incidence and relevance on clinical outcome." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60221.
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Kurz, Stephan. "cDNA-Microarray basierte Identifizierung von molekularen und prognostischen Subgruppen bei der akuten myeloischen Leukämie mit einer Inversion inv(16)/ Translokation t(16;16) und einer Translokation t(8;21)." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-64925.
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Mariani, Giacomo <1979>. "Theoretical and Experimental Study of the Magnetic Separation of Pollutants from Wastewater." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2305/.
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This Thesys reports the study of a HGMS (High GradientMagnetic Separation) process for the treatment of industrialwastewaters that considers an assisted chemical-physical pre-treatment for the removal of heavy metals through the bound by adsorption with added iron-oxide particulate matter (hematite). The considered filter, constituted by ferromagnetic stainless steel wool and permanent magnets, is studied with a new approach based on a statistical analysis that requires the study of the trajectories of the particles. Experimental activity on a laboratory device has been carried out in order to test the model.
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Salsi, Emilio <1983>. "Caratterizzazione e simulazione di processi di colata in sabbia di ghise sferoidali." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6970/.
Full textAbstract:
L’oggetto principale delle attività di tesi è la caratterizzazione numerico-sperimentale di processi di colata in sabbia di ghisa sferoidale.
Inizialmente è stata effettuata un’approfondita indagine bibliografica per comprendere appieno le problematiche relative all’influenza dei parametri del processo fusorio (composizione chimica, trattamento del bagno, velocità di raffreddamento) sulle proprietà microstrutturali e meccaniche di getti ottenuti e per valutare lo stato dell’arte degli strumenti numerici di simulazione delle dinamiche di solidificazione e di previsione delle microstrutture.
Sono state definite, realizzate ed impiegate attrezzature sperimentali di colata per la caratterizzazione di leghe rivolte alla misura ed alla differenziazione delle condizioni di processo, in particolare le velocità di raffreddamento, ed atte a validare strumenti di simulazione numerica e modelli previsionali. Inoltre sono stati progettati ed impiegati diversi sistemi per l’acquisizione ed analisi delle temperature all’interno di getti anche di grandi dimensioni.
Lo studio, mediante analisi metallografica, di campioni di materiale ottenuto in condizioni differenziate ha confermato l’effetto dei parametri di processo considerati sulle proprietà microstrutturali quali dimensioni dei noduli di grafite e contenuto di ferrite e perlite. In getti di grandi dimensioni si è riscontrata anche una forte influenza dei fenomeni di macrosegregazione e convezione della lega su microstrutture e difettologie dei getti.
Le attività si sono concentrate principalmente nella simulazione numerica FEM dei processi fusori studiati e nell’impiego di modelli empirico-analitici per la previsione delle microstrutture. I dati misurati di temperature di processo e di microstrutture sono stati impiegati per la validazione ed ottimizzazione degli strumenti numerici previsionali impiegati su un ampio intervallo di condizioni di processo.
L’impiego di strumenti affidabili di simulazione del processo fusorio, attraverso l’implementazione di correlazioni sperimentali microstrutture-proprietà meccaniche, permette la valutazione di proprietà e difettologie dei getti, fornendo un valido aiuto nell’ottimizzazione del prodotto finito e del relativo processo produttivo.This work focuses on a numerical-experimental characterization of casting processes of sand ductile iron. Initially, a deep phase of literary review has been carried out in order to completely understand the effects of the process parameters (alloy chemical composition, melt treatment and cooling rates) on defects, microstructures and mechanical properties of castings and to evaluate the state of the art of the numerical instruments of simulation of solidification dynamics and microstructure prediction. Experimental casting equipments have been designed and developed in order to measure and control the cooling rates and to validate instrument of numerical simulation and microstructure prediction. Moreover, specific methods and instruments have been designed, tested and used in order to measure and analyze temperatures inside the central parts of castings, also in case of heavy sections. Metallographic samples of material, obtained with different conditions, have been studied by means of optical analysis in order to evaluate microstructural features gradient, verifying the effect of the considered process parameters on microstructures parameters such as dimension and distribution of graphite nodules and content of ferrite and pearlite. In heavy section castings, a strong influence of macrosegregation and convective phenomena on microstructures and defects was found. The main part of the activities focused on numerical simulation FEM of the performed casting processes. The measured data of temperatures and microstructures have been used for the validation and optimization of the numerical simulations and of the analytical-empirical models for microstructure prediction in a wide range of process condition. The use of reliable instruments for simulation of casting process, with the adding of the implementation of experimental correlation microstructures-mechanical properties, allows for the evaluation of final properties and defects of castings, giving an important help in the optimization of the final product and its relative production process.
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Ascari, Alessandro <1974>. "Giunzione mediante laser di materiali difficili, ibridi ed a struttura cellulare." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6358/.
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Lo studio presentato in questa sede concerne applicazioni di saldatura LASER caratterizzate da aspetti di non-convenzionalità ed è costituito da tre filoni principali. Nel primo ambito di intervento è stata valutata la possibilità di effettuare saldature per fusione, con LASER ad emissione continua, su pannelli Aluminum Foam Sandwich e su tubi riempiti in schiuma di alluminio. Lo studio ha messo in evidenza numerose linee operative riguardanti le problematiche relative alla saldatura delle pelli esterne dei componenti ed ha dimostrato la fattibilità relativa ad un approccio di giunzione LASER integrato (saldatura seguita da un post trattamento termico) per la realizzazione della giunzione completa di particolari tubolari riempiti in schiuma con ripristino della struttura cellulare all’interfaccia di giunzione. Il secondo ambito di intervento è caratterizzato dall’applicazione di una sorgente LASER di bassissima
potenza, operante in regime ad impulsi corti, nella saldatura di acciaio ad elevato contenuto di
carbonio. Lo studio ha messo in evidenza come questo tipo di sorgente, solitamente applicata per lavorazioni di
ablazione e marcatura, possa essere applicata anche alla saldatura di spessori sub-millimetrici. In questa fase è stato messo in evidenza il ruolo dei parametri di lavoro sulla conformazione del giunto ed è stata definita l’area di fattibilità del processo. Lo studio è stato completato investigando la possibilità di applicare un trattamento LASER dopo saldatura per addolcire le eventuali zone indurite. In merito all’ultimo ambito di intervento l’attività di studio si è focalizzata sull’utilizzo di sorgenti ad elevata densità di potenza (60 MW/cm^2) nella saldatura a profonda penetrazione di acciai da costruzione. L’attività sperimentale e di analisi dei risultati è stata condotta mediante tecniche di Design of Experiment per la valutazione del ruolo preciso di tutti i parametri di processo e numerose considerazioni relative alla formazione di cricche a caldo sono state suggerite.This dissertation concerns LASER-based joining and welding applications characterized by non-conventional prerogatives. The work is divided into three main topics: LASER joining of hybrid cellular-structured materials, with particular attention to aluminum foam sandwiches and foam-cored tubes, short-pulse LASER micro welding of high carbon steels and high power density continuous wave LASER welding of structural steels. The first topic investigates the role of LASER in joining hybrid components characterized by an external dense skin and an internal foam core. In particular the possibility of achieving both the fusion welding of the skin and the restoration of the cellular structure at the welding interface is assessed and the main guidelines concerning an integrated LASER welding - LASER heat treatment processing cycle are suggested. The second topic deals with the application of a low-power nanosecond pulsed LASER source in welding high carbon steels. The study points out that an accurate selection of pulse-related parameters allows to achieve sound micro-joints characterized by a penetration between 20 and 200 microns. These results point out the possibility to consider the construction of integrated LASER manufacturing cells in which, with the same low-cost source and on the same workpiece positioning, welding, cutting, marking and texturing processes can be performed. The study is completed by the investigation of the possibility to carry out a LASER post welding heat treatment for annealing the eventual hardened zones occurring in the welded material. The last topic deals with high power density LASER welding of carbon steels: by exploiting a high brilliance fiber source, capable of achieving 60 MW/cm^2, high penetration weld beads were obtained. By means of Design of Experiment techniques the role of radiation power, welding speed and beam focal position is assessed and several considerations were made concerning the influence of this kind of process on hot cracks formation.
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Ferretti, Stefano <1976>. "Innovative technologies for Space habitats." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/958/.
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Sangiorgi, Cellini Giovanni <1977>. "Ricerca e sviluppo di tecniche integrate basate sull'analisi termofluidodinamica del processi fusori e sull'analisi stutturale per la progettazione di componenti in alluminio ad alte prestazioni." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1310/.
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Cimatti, Barbara <1964>. "Complessità tecnologica, trasferimento di tecnologia e innovazione." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2127/.
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Il presente lavoro ha come obiettivo la definizione e la misura della complessità tecnologica, al fine di costruire strumenti a supporto di tutti gli operatori che si occupano dello sviluppo e della fabbricazione di un prodotto industriale, quali progettisti di prodotto e responsabili di produzione. La ricerca è stata sviluppata attraverso le fasi di seguito descritte. Analisi dello stato dell’arte su definizioni e misure della complessità in ambito industriale
attraverso l’individuazione e studio di oltre un centinaio di pubblicazioni al riguardo. Classificazione dei metodi proposti in letteratura per la misura della complessità in cinque categorie e analisi critica dei punti di forza e di debolezza dei differenti metodi, ai fini di orientare
la elaborazione di un nuovo metodo. Sono stati inoltre analizzati i principali metodi di Intelligenza Artificiali quali potenziali strumenti di calcolo della complessità.
Indagine su tematiche correlate alla complessità quali indicatori, trasferimento tecnologico e innovazione. La complessità viene misurata in termini di un indice che appartiene alla categoria degli indicatori, utilizzati in molti ambiti industriali, in particolare quello della misura delle prestazioni di produzione. In particolare si è approfondito significato e utilizzo dell’OEE (Overall
Equipment Effectiveness), particolarmente diffuso nelle piccole medie imprese emilianoromagnole e in generale dalle aziende che utilizzano un sistema produttivo di tipo job-shop. È stato implementato un efficace sistema di calcolo dell’OEE presso una azienda meccanica locale. L’indice di complessità trova una delle sue più interessanti applicazioni nelle operazioni di trasferimento tecnologico. Introdurre un’innovazione significa in genere aumentare la complessità del sistema, quindi i due concetti sono connessi. Sono stati esaminati diversi casi aziendali di
trasferimento di tecnologia e di misura delle prestazioni produttive, evidenziando legami e influenza della complessità tecnologica sulle scelte delle imprese. Elaborazione di un nuovo metodo di calcolo di un indice di complessità tecnologica di prodotto, a partire dalla metodologia ibrida basata su modello entropico proposta dai Prof. ElMaraghy e Urbanic nel 2003. L’attenzione è stata focalizzata sulla sostituzione nella formula originale a
valori determinati tramite interviste agli operatori e pertanto soggettivi, valori oggettivi. Verifica sperimentale della validità della nuova metodologia attraverso l’applicazione della formula ad alcuni componenti meccanici grazie alla collaborazione di un’azienda meccanica manifatturiera. Considerazioni e conclusioni sui risultati ottenuti, sulla metodologia proposta e sulle applicazioni del nuovo indice, delineando gli obiettivi del proseguo della ricerca. In tutto il lavoro si sono evidenziate connessioni e convergenze delle diverse fonti e individuati in diversi ambiti concetti e teorie che forniscono importanti spunti e considerazioni sul tema della complessità. Particolare attenzione è stata dedicata all’intera bibliografia dei Prof. ElMaraghy al
momento riconosciuti a livello internazionale come i più autorevoli studiosi del tema della complessità in ambito industriale.
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Bertuzzi, Giacomo <1979>. "Caratterizzazione, fabbricazione e applicazione di manufatti in schiuma metallica." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3845/.
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Todaro, Ivan <1976>. "Sviluppo di sperimentazioni per la produzione di getti in lega di alluminio a caratteristiche difettologiche e microstrutturali controllate, per la validazione di modelli di previsione delle porosità." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4454/.
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Nei processi di progettazione e produzione tramite tecnologie di colata di componenti in alluminio ad elevate prestazioni, risulta fondamentale poter prevedere la presenza e la quantità di difetti correlabili a design non corretti e a determinate condizioni di processo.
Fra le difettologie più comuni di un getto in alluminio, le porosità con dimensioni di decine o centinaia di m, note come microporosità, hanno un impatto estremamente negativo sulle caratteristiche meccaniche, sia statiche che a fatica.
In questo lavoro, dopo un’adeguata analisi bibliografica, sono state progettate e messe a punto attrezzature e procedure sperimentali che permettessero la produzione di materiale a difettologia e microstruttura differenziata, a partire da condizioni di processo note ed accuratamente misurabili, che riproducessero la variabilità delle stesse nell’ambito della reale produzione di componenti fusi. Tutte le attività di progettazione delle sperimentazioni, sono state coadiuvate dall’ausilio di software di simulazione del processo fusorio che hanno a loro volta beneficiato di tarature e validazioni sperimentali ad hoc.
L’apparato sperimentale ha dimostrato la propria efficacia nella produzione di materiale a microstruttura e difettologia differenziata, in maniera robusta e ripetibile.
Utilizzando i risultati sperimentali ottenuti, si è svolta la validazione di un modello numerico di previsione delle porosità da ritiro e gas, ritenuto ad oggi allo stato dell’arte e già implementato in alcuni codici commerciali di simulazione del processo fusorio.
I risultati numerici e sperimentali, una volta comparati, hanno evidenziato una buona accuratezza del modello numerico nella previsione delle difettologie sia in termini di ordini di grandezza che di gradienti della porosità nei getti realizzati.The possibility to predict defects in aluminium alloy cast component, from the very beginning of the design and production phases is a crucial issue. Among the most common defects of a casting, microporosities (i.e. porosities with dimension up to hundreds of m) are highly detrimental for mechanical performances. In this work, after an in-depth bibliographic research, experimental casting devices and procedures were designed in order to produce specimen with controlled defects and microstructure, related to process condition which could be varied in the range of the actual ones, measured on the shop floor. The whole design phase of the casting devices and procedure was carried out using process simulation software which were extensively fine tuned through experimental activities. The experiment proved to be effective in producing specimen with controlled defects and microstructure, in a consistent way. Numerical models for the prediction of gas and shrinkage porosity were evaluated in terms of accuracy in the description of all of the phenomena involving nucleation and growth of porosity and possibility of implementation on industrial cases. The one considered at the state of the art underwent a validation process with the experimental data. The comparison of numerical results and experimental data showed a good match, thus the good capability of the model to predict porosity, both in magnitude and trend throughout the casting.
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Mantega, Claudio <1976>. "Metodi numerici per lo studio di centri di lavoro ad alta velocità." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/957/.
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A Machining Centre is nowadays a complex mechanical, electronic, electrical system
that needs integrated design capabilities which very often require a high time-consuming effort.
Numerical techniques for designing and dimensioning the machine structure and components
usually requires different knowledge according to the system that have to be designed. This Ph. D
Thesis is related about the efforts of the Authors to develop a system that allows to perform the
complete project of a new machine optimized in its dynamic behaviour. An integration of the
different systems developed, each of which respond to specific necessities of designer, is here
presented. In particular a dynamic analysis system, based on a lumped mass approach, that rapidly
allows to setup the drives of the machine and an Integrated Dynamic Simulation System, based on a
FEM approach, that permit a dynamic optimization, are shown. A multilevel Data Base, and an
operator interface module provide to complete the designing platform. The proposed approach
represents a significant step toward the virtual machining for the prediction of the quality of the
worked surface.
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Segatori, Antonio <1981>. "Experimental analysis and FE Modeling of Aluminium alloys Microstructural Evolution in Extrusion." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4847/.
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Extrusion is a process used to form long products of constant cross section, from simple billets, with a high variety of shapes. Aluminum alloys are the materials most processed in the extrusion industry due to their deformability and the wide field of applications that range from buildings to aerospace and from design to automotive industries. The diverse applications imply different requirements that can be fulfilled by the wide range of alloys and treatments, that is from critical structural application to high quality surface and aesthetical aspect. Whether one or the other is the critical aspect, they both depend directly from microstructure.
The extrusion process is moreover marked by high deformations and complex strain gradients making difficult the control of microstructure evolution that is at present not yet fully achieved. Nevertheless the evolution of Finite Element modeling has reached a maturity and can therefore start to be used as a tool for investigation and prediction of microstructure evolution.
This thesis will analyze and model the evolution of microstructure throughout the entire extrusion process for 6XXX series aluminum alloys. Core phase of the work was the development of specific tests to investigate the microstructure evolution and validate the model implemented in a commercial FE code. Along with it two essential activities were carried out for a correct calibration of the model beyond the simple research of contour parameters, thus leading to the understanding and control of both code and process. In this direction activities were also conducted on building critical knowhow on the interpretation of microstructure and extrusion phenomena. It is believed, in fact, that the sole analysis of the microstructure evolution regardless of its relevance in the technological aspects of the process would be of little use for the industry as well as ineffective for the interpretation of the results.
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Hausmann, Guido. "Mütterchen Wolga : ein Fluss als Erinnerungsort vom 16. bis ins frühe 20. Jahrhundert /." Frankfurt am Main : Campus, 2009. http://deposit.d-nb.de/cgi-bin/dokserv?id=3228893&prov=M&dok_var=1&dok_ext=htm.
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Hausmann, Guido. "Mütterchen Wolga ein Fluss als Erinnerungsort vom 16. bis ins frühe 20. Jahrhundert." Frankfurt, M. New York, NY Campus-Verl, 2004. http://d-nb.info/992153395/04.
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Bastian, Thomas. "Mobilitätsbezogene Einstellungen beim Übergang vom Kindes- ins Jugendlichenalter : querschnittliche Altersvergleiche bei 14- bis 16-Jährigen /." Wiesbaden : VS, Verl. für Sozialwiss, 2010. http://d-nb.info/997397756/04.
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Bastian, Thomas. "Mobilitätsbezogene Einstellungen beim Übergang vom Kindes- ins Jugendlichenalter querschnittliche Altersvergleiche bei 14- bis 16-Jährigen." Wiesbaden VS, Verl. für Sozialwiss, 2009. http://d-nb.info/997397756/04.
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Brösch, Marco [Verfasser], and Claudine [Akademischer Betreuer] Moulin. "Die Klosterbibliothek von Eberhardsklausen und ihre Bestände. Von den Anfängen bis ins 16. Jahrhundert / Marco Brösch ; Betreuer: Claudine Moulin." Trier : Universität Trier, 2015. http://d-nb.info/1197701451/34.
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Lee, Barry Everett. "The Nashville Civil Rights Movement: A Study of the Phenomenon of Intentional Leadership Development and its Consequences for Local Movements and the National Civil Rights Movement." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/history_diss/16.
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The Nashville Civil Rights Movement was one of the most dynamic local movements of the early 1960s, producing the most capable student leaders of the period 1960 to 1965. Despite such a feat, the historical record has largely overlooked this phenomenon. What circumstances allowed Nashville to produce such a dynamic movement whose youth leadership of John Lewis, Diane Nash, Bernard LaFayette, and James Bevel had no parallel? How was this small cadre able to influence movement developments on local and a national level? In order to address these critical research questions, standard historical methods of inquiry will be employed. These include the use of secondary sources, primarily Civil Rights Movement histories and memoirs, scholarly articles, and dissertations and theses. The primary sources used include public lectures, articles from various periodicals, extant interviews, numerous manuscript collections, and a variety of audio and video recordings. No original interviews were conducted because of the availability of extensive high quality interviews. This dissertation will demonstrate that the Nashville Movement evolved out of the formation of independent Black churches and college that over time became the primary sites of resistance to racial discrimination, starting in the Nineteenth Century. By the late 1950s, Nashville’s Black college attracted the students who became the driving force of a local movement that quickly established itself at the forefront of the Civil Rights Movement. Nashville’s forefront status was due to an intentional leadership training program based upon nonviolence. As a result of the training, leaders had a profound impact upon nearly every major movement development up to 1965, including the sit-ins, the Freedom Rides, the March on Washington, the birth of SNCC, the emergence of Black Power, the direction of the SCLC after 1962, the thinking of Dr. Martin Luther King, Jr., the Birmingham campaign, and the Selma voting rights campaign. In addition, the Nashville activists helped eliminate fear as an obstacle to Black freedom. These activists also revealed new relationship dynamics between students and adults and merged nonviolent direct action with voter registration, a combination considered incompatible.
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RAVAGLIA, PIETER. "Valorizzare le caratteristiche di sostenibilità dei prodotti agroalimentari italiani attraverso un approccio multidisciplinare che integra l'analisi Life Cycle Assessment con ulterriori informazioni che documentano gli impatti sociali, culturali ed economici delle attività produttive sul paesaggio e sulle comunità locali." Doctoral thesis, Università Cattolica del Sacro Cuore, 2018. http://hdl.handle.net/10280/53794.
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La normativa comunitaria ha favorito lo sviluppo di sistemi di qualità certificati. Oggi la CE sta guidando il sistema qualità verso un nuovo orizzonte: la valutazione delle prestazioni di sostenibilità di prodotti e organizzazioni, e lo sta facendo attraverso la metodologia dell'Impronta Ambientale (EF).
A livello nazionale dal 2009 il Ministero dell'Ambiente sta promuovendo un intenso programma di valutazione delle prestazioni ambientali dei prodotti e di riduzione delle emissioni di gas serra delle imprese italiane. Una delle iniziative di maggior successo è il progetto VIVA "La Sostenibilità della vitivinicoltura in Italia".
Con la pubblicazione del decreto Ministeriale n. 56 del marzo 2018 che approva lo schema volontario Made Green in Italy per l'applicazione della metodologia PEF in Italia, e con la pubblicazione del PEFCR per “Still and sparkling wine”. È chiaro che sia a livello nazionale che europeo la direzione intrapresa va verso la metodologia EF dalla Commissione Europea.
Supponendo che il protocollo VIVA possa essere influenzato anche dall'evoluzione del metodo EF; sono state valutate le possibili implicazioni legate ad una futura transizione da VIVA alla PEF, effettuando anche uno studio PEF su 27 prodotti certificati VIVA con un confronto di prestazioni tra i prodotti VIVA e i benchmark europei.EU regulations have favoured the development of certified quality schemes. Today the EC is driving the quality sector towards a new horizon; the evaluation of sustainability performance of product and organizations, and is doing it through the Environmental Footprint Methodology. At national level since 2009 the Italian Ministry for the Environment Land and Sea is promoting an intense programme for the evaluation of products’ environmental performances and for the reduction of Italian companies’ greenhouse gas emissions. One of the most successful initiative is the VIVA “Sustainability and Culture” project addressed to the wine sector. With the release of the IMELS decree n. 56 of march 2018 approving the Made Green in Italy Voluntary Scheme for PEF methodology application in Italy, and with the publication of the PEFCR for still and sparkling wine. Is clear that the direction taken at national and European level goes toward the EF methodology developed by the European Commission Assuming that the VIVA protocol may also be affected by EF evolution; possible implications linked to a future transition from VIVA to PEF were evaluated, also carrying out a PEF assessment of 27 VIVA certified products with a performance confrontation between the VIVA products and the European benchmarks.
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Eldakhakhny, Sahar. "Crosstalk between high-risk human papillomavirus E7 and p63 in cervical cancer." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/crosstalk-between-highrisk-human-papillomavirus-e7-and-p63-in-cervical-cancer(105b5422-2ef0-40a8-9209-0d1d89fb75c9).html.
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Introduction: Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. It results from cellular transformation by the high-risk human papillomavirus (HPV) oncogenes E6 and E7, which accounts for more than 99% of diagnosed cases. HPV links its life cycle to epithelial proliferation and differentiation, which requires the cells to remain active in cell cycle. p63 modulates epithelial development as well as proliferation, differentiation and DNA damage response (DDR), which makes it an important target for HPV oncoproteins to allow viral replication and survival in infected cells. Methods: In this study, small interfering RNAs targeting E7 oncoprotein and p63 in the HPV16 positive cervical cancer cell line CaSki were used. Western blotting, proliferation assays, apoptosis assays and cell cycle analysis were applied to examine the effects of E7 and p63 depletion on cell fate. Overexpression of different types of HPV-E7 was performed in the N/Tert-1 keratinocyte cell line to study the effect of E7 overexpression on p63 level. Results: E7 drives the expression of p63 at both transcript and protein levels in cervical cancer cell lines. Downregulation of E7 is accompanied by a remarkable inhibition of cell proliferation and cell cycle arrest in the G0/G1 phase. Depletion of E7 is associated with a significant reduction in p63 expression which is not due to impaired proliferation or induced differentiation. Downregulation of p63 is associated with delayed DDR in cervical cancer cells following treatment with ionising radiation. High-risk HPV E7s are more potent in inducing p63 upregulation and increasing the proliferation rates in keratinocytes. Conclusion: This work for the first time demonstrated that E7 modulates the expression of p63, which regulates DNA damage repair pathways, that promotes efficient and rapid repair of the DNA damage following ionising radiation treatment in cervical cancer cells. Tumour recurrence due to resistance to radiotherapy is common, mostly due to promoted DNA repair ability of cancer cells to reduce radiation-induced toxicity and increase cell survival in response to ionising radiation. These findings might be the key to the development of radioresistance in cervical cancer. The HPV E7-p63 axis may be a novel therapeutic target to enhance radio-sensitivity in HPV-transformed tumours.
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Marsh, Vivien. "A Trojan dragon? : CCTV news in English and the battle for global influence, 2014-16." Thesis, University of Westminster, 2018. https://westminsterresearch.westminster.ac.uk/item/q5y19/a-trojan-dragon-cctv-news-in-english-and-the-battle-for-global-influence-2014-16.
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China’s official media are nearly a decade into a global expansion programme to challenge the dominance of Anglo-American news organisations and their framing of world events. This research tackles the questions of whether Chinese media abroad deserve to be dismissed as channels for Communist Party propaganda, whether their output has journalistic merit, and whether Chinese journalism has a different character from that of the Anglosphere. The focus is on CCTV-News in English, whose ‘hard news’ output is compared with that of BBC World News TV between 2014 and 2016: previous studies of the channel have concentrated on single regions or events, political strategy or current affairs. Comparative quantitative content analysis of five constructed weeks of news is followed by frame analysis of selected events with a framework adapted to accommodate Chinese political and cultural proclivities. Subconscious editorial judgements are made manifest through a pioneering experimental technique, ‘cross-editing’, in which journalists from Britain and China swap broadcast news scripts and re-edit them as if for output on their own channel. Topics of strategic importance to Beijing are the focus of the research: news about China, and coverage of Africa including China in Africa. The empirical analysis confirms that these politically sensitive areas are handled by CCTV-News mainly in ways that are alien to editorial principles in the Anglosphere, either through lack of journalistic rigour (partial reporting and ‘positive news’) or through differences in framing such as solution-focused reporting and aversion to conflict. The analysis demonstrates the uneven editorial imperatives across CCTV-News and the improvised nature of journalistic professionalism, including how far Chinese reporters dare push the boundaries of information control. In the BBC World News output, the comparative methods reveal weaknesses in the Corporation’s professed tenets of balance and impartiality, and highlight the difficulties of telling nuanced, non-pictorial stories from distant countries while shackled by Anglo-American television ‘grammar’. The research confirms the considerable impediments to credibility occasioned by political control over CCTV’s English news output: however, it also indicates that the journalism of the Anglosphere, in the form of BBC World News, is not the universal standard many believed it to be.
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Großmann, Knut. "Tradition und Gegenwart bei der Analyse des thermischen Verhaltens spanender Werkzeugmaschinen: Tagungsband 16. Dresdner Werkzeugmaschinen-Fachseminar, 21. und 22. März 2013 Dresden: Gewidmet dem 100. Geburtstag von Prof. Dr.-Ing. habil. Dr. h.c. Horst Berthold." Technische Universität Dresden, 2013. https://tud.qucosa.de/id/qucosa%3A27057.
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Die Dresdner Werkzeugmaschinen-Fachseminare sind ein Forum zu ausgewählten Spezialthemen der Entwicklung und Nutzung von Werkzeugmaschinen.
Das 16. WZM-Fachseminar berichtetet inhaltlich detailliert von aktuellen Arbeiten im Rahmen des DFG-Sonderforschungsbereiches "Thermo-Energetische Gestaltung von Werkzeugmaschinen" (SFB/TR 96) an den Standorten Dresden, Aachen und Chemnitz.
Die Fachbeiträge berichten über experimentelle und modellgestützte Analyse von Wärmequellen und -übertragung in spanenden Werkzeugmaschinen sowie zu Lösungsansätzen zur Korrektur und Kompensation der thermo-elastischen Verlagerungen.:H. P. Schossig DMG, Pfronten: Thermik-Forschung und die Umsetzung der Erkenntnisse in Maschinenkonzepten bei DMG
K. Großmann Sprecher des DFG-SFB Transregio 96 IWM, TU Dresden: Thermo-Energetische Gestaltung von Werkzeugmaschinen
F. Klocke; M. Brockmann WZL, RWTH Aachen, K. Großmann; Ch. Städel IWM, TU Dresden: Untersuchungen des Zerspanungsprozesses hinsichtlich auftretender Wärmeströme und Temperaturen
R. Werner; St. Winkler EWA, TU Chemnitz, Ch. Brecher; D. Haber WZL, RWTH Aachen: Verlustleistungen in einer Vorschubachse und die daraus resultierende Temperaturverteilung
R. Kneer; S. Vieler WSA, RWTH Aachen, K. Großmann; St. Schroeder IWM, TU Dresden: Messungen des Wärmeübergangs an Fugenkontakten von Werkzeugmaschinen
J. Weber; Jul. Weber IFD, TU Dresden, G. Schmidt; U. Semmler Fraunhofer IWU, Chemnitz: Fluidische Kühlung von Motorspindeln und Werkzeugen
W.-G. Drossel; St. Ihlenfeldt; C. Zwingenberger Fraunhofer IWU, Chemnitz, K. Großmann; St. Schroeder IWM, TU Dresden: Modellierung des Wärmeaustauschs Maschine-Umgebung
A. Voigt; J. Wensch; A. Naumann IWR, TU Dresden: Defektkorrektur bei Mittelungsverfahren in der Zeitintegration des Temperaturverhaltens
K. Großmann; A. Galant IWM, TU Dresden, M. Beitelschmidt; M. Partzsch IFKM, TU Dresden: Strukturveränderlichkeit in FEM und Blocksimulation bei der Berechnung von Temperaturfeldern
K. Großmann; M. Merx IWM, TU Dresden: Thermografie und Nahbereichs-Fotogrammetrie zur Erfassung von Temperatur- u. Verlagerungsfeldern
Ch. Brecher; M. Wennemer WZL, RWTH Aachen: Eigenschaftsmodellbasierter Ansatz zur Korrektur thermo-elastischer Verlagerungen
K. Großmann; Ch. Städel IWM, TU Dresden: Simulative Erweiterung der Datenbasis zur korrelativen Korrektur thermo-elastischer Verlagerungen
W.-G. Drossel; Ch. Ohsenbrügge Fraunhofer IWU, Chemnitz: Materialeffekte und Funktionsmechanismen zur Wärmefluss-Steuerung
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Peters, Einir Wyn. "'Time to talk' : using the Research and Development in Organisations framework to implement and evaluate an educational psychology drop-in service for pupils over 16 years of age." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/time-to-talk-using-the-research-and-development-in-organisations-framework-to-implement-and-evaluate-an-educational-psychology-dropin-service-for-pupils-over-16-years-of-age(a2cb5803-945a-4ca1-9af0-334fae21fa0a).html.
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It is estimated that as many as 20% of children and young people experience psychological problems at any one time (The Mental Health Foundation, 1999), and research suggests that young people have many concerns that may go unnoticed by the adults around them (Cheminais, 2008). Pupils’ interest in direct access to psychological services in the form of ‘drop-in’ opportunities has previously been highlighted (Nichtern, 1978; Woolfson and Harker, 2002; Woolfson et al., 2008; Weerasinghe, 2009). Wider evidence suggests that ‘drop-in’ services may be an age-appropriate method for older adolescents to seek emotional health support. There is some research evidence to support the use of Educational Psychology ‘drop-in’ services for parents, however, there is little evidence to date regarding the use of such services with pupils, and no evidence to support the use of Educational Psychology drop-in services for a post-16 population. This thesis describes an Action Research project that was run in one secondary school in North Wales. A Trainee Educational Psychologist worked alongside a stakeholder group of school staff and other agencies in an effort to make Educational Psychologists (EPs) more accessible to post-16 pupils. The Research and Development in Organisations (RADIO) framework was applied to support the joint design and implementation of a psychological drop-in service for Year 12 and 13 pupils. Data was collected through focus groups, on-going discussion with stakeholders, and the maintenance of a research diary, each audio recorded. Data was analysed qualitatively using thematic analysis, with the key themes being fed back to the stakeholder group at pertinent stages of the RADIO model to help guide the direction of the action research project. The project did not take the anticipated course, as no pupils made use of the drop-in service during the pilot period. However, the critical realism stance adopted allowed for consideration of the underlying generative mechanisms that gave way to the outcomes achieved. Pupil’s perceptions of stigma and their negative constructions regarding the role of EPs were identified as particular barriers to direct access and participation with the service offered. The findings are discussed in relation to existing literature and the potential implications for secondary school pastoral care staff and Educational Psychology Services.
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Harrison, Charles. "Assessing malingered responding : concurrent validation of a forced-choice test using ink blot stimuli for the identification of malingered responses /." Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1850434951&SrchMode=1&sid=16&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1278707663&clientId=22256.
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Cobb, Kirsi. "A woman on the border : a feminist-structuralist-deconstructive reading of the character of Miriam in Exodus 2:1-10; 15:20-21 and Numbers 12:1-16." Thesis, Bangor University, 2011. https://research.bangor.ac.uk/portal/en/theses/a-woman-on-the-border-a-feministstructuralistdeconstructive-reading-of-the-character-of-miriam-in-exodus-2110-152021-and-numbers-12116(1b5a21a5-81d8-4ce1-a222-b36687a31d72).html.
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Miriam is a character within the Hebrew Bible who is surrounded by conflicting descriptions. On the one hand, she is Moses' sister, a leader and a cult-musician (Exodus 2:4,15:19-20); on the other hand she is a rebel and an example of ritual uncleanliness (Numbers 12: 1-16). Amidst such a wide variety of views we wish to produce a reading, a 'counter-voice', in order to illustrate how the description of Miriam as a subservient female/ a rebel is both established as well as questioned in the three texts chosen for the present study (Exodus 2: 1-10; 15:20-21; Numbers 12:1-16). We approach this endeavour with the aid of feminist, structuralist and deconstructive aims. The stand of poststructuralist feminism is stated to be the vantage point brought to bear upon the texts under analysis with specific interest given to any issues related to the treatment of Miriam and/or other female character(s) within the passages. Structuralist critique is used in order to establish a normative reading of the texts in question with the aid of more traditional research, which is then questioned by the means of deconstructive critique in order to illustrate how the depiction of Miriam in the first reading is at tension with the one uncovered in the limits and inconsistencies of biblical texts. Through the above observations we wish to portray Miriam as a woman who constantly breaks through any predisposed characterisations imposed on her by the biblical text and/or previous interpretations. We present her as a 'woman on the border', disturbing the perceived stability of male domination in the texts in which she appears.
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Flowers, Michael. "The messianic forerunner concept in earliest Christianity (Q)." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-messianic-forerunner-concept-in-earliest-christianity-q(7374496a-d860-4d30-a647-acb2c343db66).html.
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In this thesis I consider the messianic forerunner concept within "Q" (which I take to be a source used by all three of the synoptic authors). I argue that at least five units in Q (3:2-3+7-9+16b-17; 3:21-22; 7:18-20+22-23; 7:24-27; 7:28) envisage John as a messianic forerunner to the Messiah Jesus. The messianic forerunner concept is therefore quite pervasive in Q and cannot be said to have originated with the evangelist Mark, as is sometimes supposed. Q attempts to deal with the historical fact that Jesus had not fulfilled Israel's messianic expectations. It did this by portraying Jesus as a rejected Messiah whose redemptive mission had been thwarted by Israel's unbelief. Jesus will ultimately redeem Israel but this will take place at his second coming and that cannot take place until Israel repents. I consider whether Q's redactor(s) utilised any earlier sources. I find this not to have been the case in Q's Prologue (3:2-3+7-9+16b-17) or in Jesus' Baptism by John (3:21-22). Earlier source material can, however, be detected in 7:18-19+22-23; 7:24-27; and 7:28. I consider whether any of this latter material derives from a rival "Baptist" source and conclude that it does not. The question of whether the messianic forerunner concept had its origins in Judaism prior to Jesus and his new movement can therefore not be established by any of the Q units examined in this thesis. What can be established, however, is that the concept goes back to some of the earliest traditions of Jesus' followers.
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Schwiertz, Ivonne. "Inzidenz von therapieinduzierten, AML-assoziierten genetischen Aberrationen am Beispiel der Translokationen t(8;21), t(9;22) und Inversion 16." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3E17-E.
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Du, Juan [Verfasser]. "RAS, KIT, FLT3 and JAK2 gene mutations in Acute Myeloid Leukemia (AML) with inv(16) and t(8;21) : incidence and relevance on clinical outcome / presented by Juan Du." 2007. http://d-nb.info/997413808/34.
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Kurz, Stephan [Verfasser]. "cDNA-Microarray basierte Identifizierung von molekularen und prognostischen Subgruppen bei der akuten myeloischen Leukämie mit einer Inversion inv(16), Translokation t(16;16) und einer Translokation t(8;21) / vorgelegt von Stephan Kurz." 2008. http://d-nb.info/997977353/34.
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Wen-Chin, Yen, and 顏文欽. "The Study of the Relationship of Employee''s Satisfaction with Company''s Policy on Profit Sharing, Stock Ownership and its Corresponding Impact on Employee''s Job Involvement and Intention of Resignation.(Employees in 16 Public Listed Companies of IC Ind." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/10605152812621530047.
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