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Journal articles on the topic 'Invasive ductal breast carcinoma non special type'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ioannis, Manolis, Kafiri Georgia, Venetikou Maria, Thalassinos Nikolaos, and Anthouli-Anagnostopoulou Fragkiski. "Prognostic factors of Invasive Ductal Breast Carcinoma Non Special Type (NST). A Study of 98 cases." REVIEW CLINICAL PHARMACOLOGY AND PHARMACOKINETICS, INTERNATIONAL EDITION 37, no. 2 (2023): 53–62. https://doi.org/10.5281/zenodo.8337644.

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<em>Prognostic factors of histological subtypes in breast cancer, is still not well established, guidelines based on the histological subtype alone. The decisions for therapy are guided mostly independently of the histological subtype and are also guided by biomarkers and tumor stage. We analyzed a special histological subtype, Invasive Ductal Breast Carcinoma Non Special Type and correlated with patient’s age, tumor grade, comedo type necrosis, necrosis, ER and PR receptors, Ki67 expression, HER2 status, pT tumor stage, pN lymph nodes stage, TNM classification and clinical tumor stage,

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Aschie, Mariana, Gabriela Izabela Baltatescu, Georgeta Camelia Cozaru, Anca Mitroi, and Manuela Enciu. "Morphopathological and immunohistochemical features of a pure mucinous breast carcinoma – Case report." ARS Medica Tomitana 22, no. 3 (2016): 174–80. http://dx.doi.org/10.1515/arsm-2016-0029.

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AbstractPure mucinous carcinoma is a rare special type of breast carcinoma with a 2% incidence and it is usualy asociated with a good prognosis. It must distingished from the mixed subtype of mucinos breast carcinoma, which has an invasive non-mucinous component in more than 10% of the tumor and change the favourable outcome of the first subtype. In this report we present a case of a premenopausal woman with a lump in right breast wich histopathologically proved to be a pure mucinous carcinoma associated with high grade ductal carcinoma in situ. Immunohistochemical and ancillary studies demons

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3

Nakagawa, Tsuyoshi, Goshi Oda, Hiroki Mori, et al. "Prognosis of Subcutaneous Mastectomy for Special Types of Breast Cancer." Medicina 58, no. 1 (2022): 112. http://dx.doi.org/10.3390/medicina58010112.

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Background and objectives: In the treatment of the special type of breast cancer (STBC), the choice of chemotherapeutic agents is often based on the characteristic features of the histological type. On the other hand, the surgical strategy is usually determined by the tumor size and presence of lymph node metastasis, and the indication for immediate reconstruction is rarely discussed based on the histological type. The prognoses of STBC and invasive ductal carcinoma of the breast (IDC) patients who underwent subcutaneous mastectomy (SCM) with immediate reconstruction at our institution were co

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Ameer, Amna, Farhan Akhtar, Hafeez Ud Din, and Rabia Ahmad. "IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI." PAFMJ 71, no. 1 (2021): 7–11. http://dx.doi.org/10.51253/pafmj.v71i1.4687.

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Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triplenegative breast carcinoma. Study Design: Cross sectional study. Duration and Place of Study: This study included 30 cases confirmed as triple negative breast carcinoma atArmed Forces Institute of Pathology Rawalpindi, from Jan to Jul 2018. Methodology: Anti-androgen receptor antibody was applied and assessed. Positive expression was defined asgreater and equal to 10% nuclear immunostaining. SPSS-24 was used for analyzing data. Results: Out of 30 cases of triple negative

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Sayed, S., Z. Moloo, S. Mukono, et al. "Pathologic characteristics of breast cancer with special emphasis on prevalence of triple-negative breast cancer from Kenya: A 4-year experience." Journal of Clinical Oncology 29, no. 27_suppl (2011): 35. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.35.

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35 Background: Previous sub classification of breast cancer in Kenya has been fraught by small sample size, non uniform staining methodology and lack of independent review. Triple Negative Breast Cancer (TNBC) is a “special interest” cancer since it represents a significant proportion of breast cancer patients and is associated with a poorer prognosis. We aimed to determine the estrogen receptor (ER), progesterone receptor (PR) and Her2/neu receptor characteristics of breast cancers and the prevalence of TNBC diagnosed at Aga Khan University Hospital, Nairobi (AKUHN) between 2007 to date. Meth

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de Faria Castro Fleury, Eduardo, Caio Castro, Mario Sergio Campos do Amaral, and Décio Roveda Junior. "Management of Non-Mass Enhancement at Breast Magnetic Resonance in Screening Settings Referred for Magnetic Resonance-Guided Biopsy." Breast Cancer: Basic and Clinical Research 16 (January 2022): 117822342210958. http://dx.doi.org/10.1177/11782234221095897.

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Rationale and Objectives: According to the Breast Imaging and Reporting Data System (BI-RADS), one of the main limitations of MRI is diagnosing the non-mass enhancement (NME). The NME lesion is challenging since it is unique to the MRI lexicon. This study aims to report our experience with NME lesions diagnosed by MRI referred for MRI-guided biopsies and discuss the management and follow-up of these lesions. Materials and Methods: We retrospectively evaluated all MRI-guide breast biopsies. We included all patients referred for NME breast MRI-guided biopsy in screening settings. All patients ha

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Manish, Kumar Jha, Imteyaz Alam Md., Bharti Madhu, and Kumari Poonam. "A Hospital Based Observational Assessment of the Histopathology of Benign Proliferative Breast Lesions in Peritumoral Area of Carcinoma Breast." International Journal of Current Pharmaceutical Review and Research 15, no. 08 (2023): 144–48. https://doi.org/10.5281/zenodo.12543741.

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AbstractAim: The aim of the study was to determine histopathological features of different subtypes of carcinoma breastand correlate with the presence of proliferative lesions of breast in peritumoral area.Methods: This Observational study was conducted for a period of 1 year at department of Pathology,Darbhanga Medical College and Hospital, Darbhanga, Bihar, India and A total of 100 cases that satisfied theinclusion criteria were included in this study. Specimens were received in 10% Formalin. Clinical details, grossfindings including tumor size were noted.Results: Age group of patients inclu

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Putri, Helenia, Maria A. Kristina, Devita Widjaja, Bernard A. Baskoro, Erna Kristiani, and Rusli Muljadi. "Distributions of Breast Cancer Primary Tumor Locations in Indonesian Patients." Medicinus 9, no. 3 (2023): 86. http://dx.doi.org/10.19166/med.v9i3.6970.

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<p><strong>Introduction:</strong> Overseas studies have shown various distributions of breast cancer primary tumor locations based on stages and histopathologic types. Based on them, breast cancer was consistently reported to be found on theleft breast more than the right. Breast cancer laterality was estimated to be one of the determinant factors in prognosis. In Indonesia, there are only a few studies on the laterality of breast cancer, as well as the characteristics that accompany it. The aim of this study is to know the distributions of primary breast cancer tumor locatio

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Imoto, S., S. Morita, M. Kitajima, T. Aikou, and Y. Kitagawa. "Early recurrence of breast cancer after sentinel node navigation surgery: A multicenter prospective study in Japan." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11530-e11530. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11530.

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e11530 Background: To assess lymphatic mapping technique and prognosis after sentinel node navigation surgery (SNNS), the Japanese society for SNNS conducted a non-randomized multi-center prospective study on SNNS in early breast cancer. Primary endpoint is to evaluate the success rate and adverse events of SNNS, and secondary endpoint is to observe the outcome of patients who underwent SNNS during 5 years. Methods: We demonstrated the results of primary endpoint at 2007 ASCO annual meeting (#606). Fourteen hundred and sixty-eight cases had pre-registration from 65 investigators at 23 institut

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Yamanaka, Taro, Tatsunori Shimoi, Mai Onishi, et al. "Abstract P3-05-24: Mapping the Genomic Landscape: Comprehensive Profiling of Diverse Histological Types of Breast Cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–05–24—P3–05–24. https://doi.org/10.1158/1557-3265.sabcs24-p3-05-24.

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Abstract Introduction: Breast Cancer (BC) is a highly heterogeneous tumor consisting of various histological types. Data on genomic alterations (GAs) in special types of breast cancer, which account for about 10% of all breast cancers, remain limited. We aimed to clarify genomic profiles of BC, especially focusing on breast cancer of special type. Methods: We retrospectively reviewed data on female patients with unserectable/metastatic BC who underwent comprehensive genomic profiling (CGP) tests and were registered for the Center for Cancer Genomics and Advanced Therapeutics in Japan from June

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Sanvido, Vanessa M., Silvio E. Bromberg, Antonio R. Junior, Bruna Mayumi T. Tachibana, and Afonso Nazário. "Abstract P4-07-48: Preliminary results of the FIRST (FreezIng bReaST cancer in Brazil) trial: a before-after study." Cancer Research 83, no. 5_Supplement (2023): P4–07–48—P4–07–48. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-07-48.

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Abstract Background: Image-guided tumor ablation is a non-surgical minimally invasive therapy available for the local treatment of carcinomas as an alternative to surgical treatment. However, studies evaluating this therapy in early breast cancer present variable success rates, raising the question of whether omitting surgery is permissible. Ongoing studies such as the Frost and Ice3 Trial may change the context of cryoablation in the treatment of early breast cancer. Objective: The main objective of this study is to assess the effectiveness of cryoablation in the local treatment of early brea

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Makhlouf, Shorouk, Nehal M. Atallah, Susanna Polotto, Andrew H. S. Lee, Andrew R. Green, and Emad A. Rakha. "Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype." Cancers 16, no. 10 (2024): 1893. http://dx.doi.org/10.3390/cancers16101893.

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Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a diverse group of tumours with distinct features. This study aims to examine the clinicopathological and prognostic features of different variants of ILC, with a particular focus on characterising aggressive subtypes. Methods: A large (n = 7140) well-characterised and histologically reviewed BC cohort with treatment and long-term follow-up data was investigate

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Oesterreich, Steffi, Laura Savariau, Ye Qin, et al. "Abstract P2-09-29: Landscape analysis of breast cancer ovarian metastases reveals biology and potential therapeutic targets." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–09–29—P2–09–29. https://doi.org/10.1158/1557-3265.sabcs24-p2-09-29.

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Abstract Background: Treatment resistance and metastases occur in 10-20% of patients with invasive lobular carcinoma (ILC), the most common special histological subtype of breast cancer. ILC often metastasize to the ovary, a site that is less common for the majority of no special type tumors (NST) also referred to as invasive ductal carcinoma (IDC). The hallmark of ILC is loss of E-cadherin (CDH1), which maps to chromosome 16q. There are limited studies on genomics and transcriptomics of ovarian metastases in patients with breast cancer. Methods: Mutations and copy number changes were analyzed

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Pareja, Fresia, Higinio Dopeso, Yikan Wang, et al. "Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics." Cancer Research 84, no. 9_Supplement (2024): GS03–04—GS03–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs03-04.

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Abstract Background: Invasive lobular carcinoma (ILC) of the breast is the second most common histologic subtype of breast cancer (BC), following invasive ductal carcinoma of no special type (IDC-NST). The hallmark histologic feature of ILC is cellular discohesiveness, the result of bi-allelic inactivation of CDH1, and represents an important genotypic-phenotypic correlation in BC. Although most ILCs harbor CDH1 loss-of function mutations associated to loss-of-heterozygosity (LOH) of the wild type-allele, a subset of ILCs lack these alterations despite displaying a typical lobular phenotype. H

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Opoku, Francis, Kweku Bedu-Addo, Nicholas Akinwale Titiloye, Elijah Atta Manu, Charity Ameh-Mensah, and Babatunde Moses Duduyemi. "Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana." PLOS ONE 16, no. 10 (2021): e0258543. http://dx.doi.org/10.1371/journal.pone.0258543.

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Background Inactivation or mutation of the tumour suppressor gene p53 or its regulator mouse double minute 2 (MDM2) is the commonest event in breast cancer. These altered genes usually express abnormally high levels of their proteins in many carcinomas. The phenotypic expression of p53 and MDM2 in breast cancer cases in our setting is not known. This study investigated the expression of the tumour suppressor protein p53 and its regulator MDM2, using immunohistochemistry in a Ghana breast cancer cohort. Method A 9-year retrospective cross-sectional study on archived tissue blocks–formalin fixed

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Mundim, Fiorita, Angela Logullo, Karine Infante, et al. "Abstract P1-09-01: Combination of tumor-infiltrating lymphocytes (TILS) and tumor-stroma ratio (TSR) in breast cancer: utility to guide clinical treatment of breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–09–01—P1–09–01. https://doi.org/10.1158/1557-3265.sabcs24-p1-09-01.

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Abstract Introduction: Breast cancer is the most common malignant tumour in women and the leading cause of death among them. The incidence rate of breast cancer among women surpassed that of lung cancer in 2020, making it the most common neoplasm in the world, with the exception of non-melanoma skin cancer. The most common histological type is non-special invasive carcinoma (SOE - formerly known as infiltrating ductal carcinoma). Our study highlights the need for new indicators to guide clinical treatment, as the response of breast cancer to anti-HER2 target therapy may be affected by the leve

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Pareja, Fresia, Arnaud Da Cruz Paula, Christopher J. Schwartz, et al. "Abstract P1-05-17: Structural Variants Affecting CDH1 in Breast Invasive Lobular Carcinoma." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–05–17—P1–05–17. https://doi.org/10.1158/1557-3265.sabcs24-p1-05-17.

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Abstract Background: Invasive lobular carcinoma (ILC) is the most frequent special histologic subtype of breast cancer (BC). ILC displays a characteristic discohesive phenotype, caused by inactivation of CDH1 (E-cadherin) that plays key roles in cell-to-cell adhesion. CDH1 bi-allelic inactivation is due to loss-of-function CDH1 mutations associated with loss of heterozygosity of the wild-type allele (LOH) in most (∼80%) cases. A subset of ILCs, however, lack CDH1 mutations despite displaying a lobular phenotype, and their molecular underpinning is yet to be determined. Here we sought to elucid

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Lin, Lawrence H., Ivy Tran, Yiying Yang, et al. "Abstract P2-23-07: DNA Methylation Analysis of Triple Negative Breast Cancers." Cancer Research 83, no. 5_Supplement (2023): P2–23–07—P2–23–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-23-07.

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Abstract Background: Triple negative breast cancers (TNBC) are characterized by the absence of estrogen receptors, progesterone receptors, and HER2 receptors on immunohistochemical analysis (IHC). This subtype of breast cancer has been traditionally associated with unfavorable prognosis. TNBC includes morphologically diverse mammary carcinomas including apocrine, metaplastic, medullary and other less common variants with heterogeneous clinical behavior and outcome. Despite previous efforts to further characterize TNBC with genomic and transcriptomic techniques, there is no specific targeted th

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Schmitz, Renée SJM, Sandra W. van den Belt-Dusebout, Chiara Cresta, et al. "Abstract P1-22-02: Subsequent risk of ipsilateral breast events in a multinational DCIS cohort of 48.619 patients: A meta-analysis within the PRECISION consortium." Cancer Research 82, no. 4_Supplement (2022): P1–22–02—P1–22–02. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-22-02.

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Abstract Background: The PRECISION (PREvent ductal Carcinoma In Situ Invasive Overtreatment Now) CRUK Grand Challenge project focusses on discriminating hazardous from indolent ductal carcinoma in situ (DCIS). Aim of these analyses is to identify factors associated with a lower or higher risk of developing invasive breast cancer after an initial DCIS diagnosis. Knowledge of these factors is crucial in our quest to reducing overtreatment for women with DCIS. Many clinicopathological features are hypothesized to be important factors affecting the risk of a subsequent breast lesion. Most studies

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Iqbal, Md Samim, Urvashi Ghosh, Rina Mukherjee, Shyamalendu Mandal, Ankit Deb, and Jayeeta Dutta. "Invasive Lobular Carcinoma of Breast with Extracellular Mucin: A Novel Entity." Journal of Medical Sciences and Health 9, no. 3 (2023): 343–46. http://dx.doi.org/10.46347/jmsh.v9i3.22.469.

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Invasive carcinoma of no special type (NST) or ductal carcinoma is the most common type of invasive breast cancers. Invasive lobular carcinoma (ILC) is the most common special variant amongst breast cancers that lacks some of the common features associated with breast cancers e.g. absence of desmoplastic reaction and infrequent mitosis. Some cases of ILC produce intracellular mucin that pushes the nucleus to one side, creating the characteristic signet ring cell morphology. Extracellular mucin secretion is essentially described in association with mucinous breast carcinoma and ductal carcinoma

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Bomeisl, Philip E., Cheryl L. Thompson, Lyndsay N. Harris, and Hannah L. Gilmore. "Comparison of Oncotype DX Recurrence Score by Histologic Types of Breast Carcinoma." Archives of Pathology & Laboratory Medicine 139, no. 12 (2015): 1546–49. http://dx.doi.org/10.5858/arpa.2014-0557-oa.

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ContextOncotype DX (ODX) is a widely used commercial assay that estimates the risk of distant recurrence and may predict the benefit of chemotherapy in a subset of breast cancers. Some studies have shown the ability to predict Oncotype DX recurrence score (ODXRS), based on routinely reported pathologic features; however, there are limited data correlating specific histologic type of breast cancer to ODXRS.ObjectiveTo compare ODXRS to specific histologic types of breast cancer.DesignOne hundred eighty-four cases were sent for ODXRS testing and the results were compared with histologic type and

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Shubbar, Yassir Alaa Muhammed Hassan. "CORRELATION BETWEEN DIFFERENT CLINICOPATHOLOGICAL PARAMETERS AND MOLECULAR SUBTYPES OF FEMALE BREAST CARCINOMA IN SOUTH REGION OF IRAQ." Wiadomości Lekarskie 76, no. 1 (2023): 97–107. http://dx.doi.org/10.36740/wlek202301114.

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The aim: To correlate variable clincopathological parameters with molecular subtypes of the breast carcinoma, which affect the prognosis and management of breast malignancy. Materials and methods: In this study a total of 511 female patients with breast carcinoma were included, ranging from 32 to 85 years of age, with 35.8% premenopausal and 64.1% being post-menopausal. The sample slides were stained immunohistochemically for estrogen receptors (ER), progesterone receptors (PR), ki67 and HER2, the tumors were graded histologically using the Nottingham criteria system. Results: Most tumors (72.

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Kumar, B. Sampath, MS Kalyan Kumar, V. Vijayalakshmi, R. Kannan, and M. Mohamed Hanif. "A Case Series on Rare Types of Carcinoma Breast." New Indian Journal of Surgery 13, no. 1 (2022): 43–47. http://dx.doi.org/10.21088/nijs.0976.4747.13122.7.

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Carcinoma Breast is a common occurrence in women. Most common pathological type being invasive ductal carcinoma: No Special Type. Carcinoma breast is a systemic disease and its management requires a multimodal treatment including surgery, chemotherapy, radiotherapy, hormonal therapy and immune therapy based on the type and stage of the disease. Here we are presenting a case series of rarer pathological types of carcinoma breast namely. 1: Solid papillary carcinoma with neuroendocrine differentiation, 2: Metaplastic carcinoma of breast, 3: Invasive carcinoma breast mimicking as sclerosing adeno

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Saeed, Muneerah, Marya Saeed, Sadaf Abbas, Yousuf Siddiqui, and Vishal Teja. "Coexisting lactating adenoma and invasive breast carcinoma: A case report and review of literature." IP Journal of Diagnostic Pathology and Oncology 9, no. 1 (2024): 76–79. http://dx.doi.org/10.18231/j.jdpo.2024.014.

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Lactating adenomas are the most common masses occurring during pregnancy. Although they are not thought to carry an increased risk of malignancy, there are rare cases of co-existence of Lactating adenoma and Invasive breast carcinoma. We present a 24-year-old lactating woman with an enlarging breast lump for 1 year. Histopathological examination of the resected mass showed lactating adenoma and invasive ductal carcinoma, no special type. This may have been a collision between a separate lactating adenoma and an invasive ductal carcinoma or a malignant transformation of a lactating adenoma. Ana

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Chen, Zheling, Jiao Yang, Shuting Li, et al. "Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma." PLOS ONE 12, no. 9 (2017): e0182397. http://dx.doi.org/10.1371/journal.pone.0182397.

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Cosar, Rusen, Necdet Sut, Sernaz Topaloglu, et al. "Classifying invasive lobular carcinoma as special type breast cancer may be reducing its treatment success: A comparison of survival among invasive lobular carcinoma, invasive ductal carcinoma, and no-lobular special type breast cancer." PLOS ONE 18, no. 7 (2023): e0283445. http://dx.doi.org/10.1371/journal.pone.0283445.

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Purpose The literature contains different information about the prognosis of invasive lobular carcinoma of breast cancer (BC). We aimed to address the inconsistency by comparatively examining the clinical features and prognosis of invasive lobular carcinoma patients in our university and to report our experience by dividing our patients into various subgroups. Patients and methods Records of patients with BC admitted to Trakya University School of Medicine Department of Oncology between July 1999 and December 2021 were reviewed. The patients were divided into three groups (No-Special Type BC,

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Boukhechba, M., H. Kadiri, and B. El Khannoussi. "Invasive Lobular Carcinoma of the Breast with Extracellular Mucin: Case Report of a New Variant of Lobular Carcinoma of the Breast." Case Reports in Pathology 2018 (2018): 1–3. http://dx.doi.org/10.1155/2018/5362951.

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Invasive carcinoma of no special type (NST) or ductal carcinoma is the largest group of invasive breast cancers. Invasive lobular carcinoma (ILC) is the second most common histological type; it comprises 5%–15% of all invasive breast cancers. Historically, lobular neoplasia and invasive lobular carcinoma may produce intracellular mucin that pushes the nucleus to one side, creating the characteristic signet ring cell morphology. The extracellular mucin secretion is essentially described in mucinous breast carcinoma. Mucinous differentiation can be seen in small areas of NST carcinoma, but recen

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Srebnijs, Andrejs, Sergejs Isajevs, Jānis Eglītis, Viesturs Krūmiņš, Juris Bērziņš, and Uldis Vikmanis. "Distribution And Clinicopathological Features Of Breast Cancer Histological Subtypes In Latvia." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 69, no. 1-2 (2015): 14–19. http://dx.doi.org/10.1515/prolas-2015-0001.

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Abstract Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of our study was to determine the distribution of breast cancer histological and molecular subtypes, and their relationship with clinical and pathological characteristics. A total of 561 patients who underwent breast carcinoma surgical treatment from January 2003 till December 2012 were enrolled in the study. In total, invasive ductal carcinomas not otherwise specified (IDC-NOS) plus invasive ductal carcinomas no special type (IDC-

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Sidabutar, Dwi Feris, and Selamat Budijitno. "Chemotherapy management of breast cancer patients according to the clinicopathological characteristics at Dr. Kariadi General Hospital, Semarang 2020-2022." Bali Medical Journal 14, no. 1 (2024): 264–68. https://doi.org/10.15562/bmj.v14i1.5488.

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Background: Breast cancer has different histopathological features and can be classified into two, namely invasive and non-invasive breast cancer. Management that can be given to breast cancer patients includes surgery (surgery), chemotherapy, radiation therapy, and hormonal therapy. This study aims to evaluate the chemotherapy management of breast cancer patients according to the clinicopathological characteristics at Dr. Kariadi General Hospital, Semarang 2020-2022. Methods: A cross-sectional study was conducted among 45 patients at Dr. Kariadi General Hospital with a total sampling techniqu

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Abdulrazaq, Alaa Abdulqader. "E-cadherin Expression in Invasive Mammary Carcinoma." Medical Journal of Babylon 21, no. 2 (2024): 389–93. http://dx.doi.org/10.4103/mjbl.mjbl_1006_23.

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Abstract Background: E-cadherin is an adhesion molecule that is frequently expressed in normal epithelial tissues. It is essential for many cellular processes, including organ formation, stratification, and epithelial polarization. Objective: This study examines E-cadherin expression for subclassifying invasive breast cancer. E-cadherin expression also decreased with age, histopathological type, grade, and stage. Materials and Methods: This prospective study included 249 breast cancer patients who underwent surgery at a private facility in Baghdad, Iraq. The patients’ clinical data were analyz

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Bonnet, Sarah E., Gloria J. Carter, and Wendie A. Berg. "Encapsulated Papillary Carcinoma of the Breast: Imaging Features with Histopathologic Correlation." Journal of Breast Imaging 2, no. 6 (2020): 590–97. http://dx.doi.org/10.1093/jbi/wbaa068.

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Abstract Encapsulated papillary carcinoma (EPC) is a rare, clinically indolent breast malignancy most common in postmenopausal women. Absence of myoepithelial cells at the periphery is a characteristic feature. Mammographically, EPC typically presents as a mostly circumscribed, noncalcified, dense mass that can have focally indistinct margins when there is associated frank invasive carcinoma. Ultrasound shows a circumscribed solid or complex cystic and solid mass, and occasional hemorrhage in the cystic component may produce a fluid-debris level; the solid components typically show intense was

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Pun, Chin Bahadur, Sadina Shrestha, Ranjan Raj Bhatta, et al. "A Retrospective Analysis of Breast Cancer at BPKMCH, Nepal." Nepalese Journal of Cancer 4, no. 1 (2020): 98–101. http://dx.doi.org/10.3126/njc.v4i1.31852.

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Introduction: Breast cancer is the most common cancer and also the leading cause of cancer related mortality in women worldwide which impact 2.1 million women each year. Breast cancer rates are increasing in nearly every region globally. Methods: This was retrospective study at Department of Pathology in B P Koirala Memorial Cancer Hospital effective from 15 April 2018 to 14 April 2019. All the data were retrieved and analyzed. Results: Total 205 breast cancer cases were analyzed, among them 198 cases were females accounting 96.5 %and 7 cases were males accounting 3.5 %.Among 205 cases,

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Lghamour, Dr Khalid, Dr Yacir Elalami, and Pr Hafid Hachi. "Invasive Carcinoma of the Breast of the Nonspecific Type about 3 Cases." Scholars Journal of Applied Medical Sciences 12, no. 11 (2024): 1509–17. http://dx.doi.org/10.36347/sjams.2024.v12i11.013.

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Breast cancer is the leading cancer in women worldwide, and the leading cause of cancer-related death in women. Invasive cancer accounts for over 90% of all histological types. The most common breast cancer (95%) is adenocarcinoma, which develops from the epithelial cells of the mammary gland. Infiltrating or invasive carcinoma includes the common infiltrating ductal carcinoma (IDC) (81%), IDC with a predominantly intraductal component (4%), infiltrating lobular carcinoma (10%), usually bilateral, and even rarer forms. Non-specific infiltrating carcinoma is the most common histological type of

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ul Haq, Raja Najam. "Clinicopathological Variants of Breast Cancer in a Tertiary Care Hospital in Pakistan." Annals of Punjab Medical College 15, no. 1 (2021): 28–31. http://dx.doi.org/10.29054/apmc/2021.828.

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Background: Breast cancer is a growing phenomenon among females which has ever-lasting ramifications on the patient as well as the family. The only way of subjugating breast cancer is through an efficient and effective screening and subsequent treatment process. Objective: This study aimed at identifying the different clinicopathological patterns of breast cancer and the age group most frequently targeted by CA breast. Study Design: A prospective study. Settings: Fauji Foundation Hospital (FFH), Rawalpindi and Foundation University Medical College (FUMC) Pakistan. Duration: Six months from Jan

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Nanev, Vasil, Silvia Naneva, Angel Yordanov, et al. "Lymphoepithelioma-like Carcinoma of the Breast Synchronous with a High-Grade Invasive Ductal Carcinoma and Ductal Carcinoma in Situ in a Different Quadrant of the Same Breast: A Case Report." Medicina 58, no. 9 (2022): 1146. http://dx.doi.org/10.3390/medicina58091146.

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Lymphoepithelioma-like breast carcinoma (LELC) is a rare type of malignant breast tumor that is not included in the current edition of the World Health Organization (WHO) classification of breast tumors. Currently, there are no clearly defined therapeutic strategies, and the general information on breast LELC is based on sporadic clinical cases described in the medical literature. We present a clinical case that describes a 49-year-old woman with a tumor formation in the right breast, histologically verified as LELC, together with a non-palpable, synchronous high-grade invasive ductal carcinom

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Conti, Marco, Francesca Morciano, Silvia Amodeo, et al. "Special Types of Breast Cancer: Clinical Behavior and Radiological Appearance." Journal of Imaging 10, no. 8 (2024): 182. http://dx.doi.org/10.3390/jimaging10080182.

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Breast cancer is a complex disease that includes entities with different characteristics, behaviors, and responses to treatment. Breast cancers are categorized into subgroups based on histological type and grade, and these subgroups affect clinical presentation and oncological outcomes. The subgroup of “special types” encompasses all those breast cancers with insufficient features to belong to the subgroup “invasive ductal carcinoma not otherwise specified”. These cancers account for around 25% of all cases, some of them having a relatively good prognosis despite high histological grade. The p

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Kim, Mi-Jung, Gyungyub Gong, Hee Jae Joo, Se-Hyun Ahn, and Jae Y. Ro. "Immunohistochemical and Clinicopathologic Characteristics of Invasive Ductal Carcinoma of Breast With Micropapillary Carcinoma Component." Archives of Pathology & Laboratory Medicine 129, no. 10 (2005): 1277–82. http://dx.doi.org/10.5858/2005-129-1277-iaccoi.

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Abstract Context.—A micropapillary carcinoma (MC) component is generally considered to behave aggressively. Although several reports have described the prognostic significance of MC in breast carcinomas, immunohistochemical findings of MC, especially as compared to non-MC, are rarely described. Objective.—We compared clinicopathologic and immunohistochemical findings between 38 cases of invasive breast carcinoma with an MC component (IMC) and 217 cases of invasive breast carcinoma without an MC component (NIMC). Design.—We constructed a tissue microarray from 38 cases of IMC and performed immu

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Golmohammadi, Rahim, Mohammad Reza Mohajeri, Alireza Mosavi Jarrahi, Ali Reza Moslem, Akbar Pejhan, and Ali Gohari. "Histopathologic Characteristics of Invasive and Non-invasive Ductal Tumors have Relationship with Different Phenotypes of ER / PR Receptors in Breast Cancer Patients." Asian Pacific Journal of Cancer Biology 6, no. 3 (2021): 181–85. http://dx.doi.org/10.31557/apjcb.2021.6.3.181-185.

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Objective: Contradictory reports have been published regarding the expression levels of the hormone receptors of estrogen and progesterone (ER / PR) and theirclinical importance in diagnosis of breast cancer. The aim of this study was to evaluate the relationship between pathological features of invasive and non-invasive ductal tumors by different ER / PR phenotypes. Methods: This descriptive-analytical study was performed on 74 specimens of breast cancer referred to Isfahan Hospitals for diagnosis between 2015 - 2018. After fixation of the specimens in formalin, tissue passage, cross section

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WASHIL, ASAAD FAKHIR, Özcan ÖZKAN, Maysaa Ghazi Jumaa, and Husam Al-hraishawi. "DETECTION OF EPSTEIN-BARR VIRUS (EBV) IN WOMEN WITH BREAST CANCER IN IRAQ USING IN-SITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL TECHNIQUES." SOUTHERN JOURNAL OF SCIENCES 33, no. 39 (2025): 86–104. https://doi.org/10.48141/2764-5959.07.v33.n39.2025_washil_pgs_86_104.pdf.

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Background: The Epstein-Barr virus (EBV) has recently been identified in human breast cancer globally, potentially contributing to the initiation and progression of this malignancy, as well as gastric cancer, nasopharyngeal carcinoma, and bladder cancer. It has been newly associated with breast cancer. Globally, breast cancer affects more women than any other type of cancer. In Iraq, the prevalence of breast cancer is comparable. Aims: The study examined Iraqi women diagnosed with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) to detect Epstein-Barr Virus Nuclear Antigen-

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Said, Taimaa T. M., Alaa Sheet, and Bilal Nuaman. "The Role of Elastography in Predicting the Grade of Mammary Ductal Carcinoma." Iraqi Journal of Medical Sciences 20, no. 2 (2022): 233–38. http://dx.doi.org/10.22578/ijms.20.2.10.

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Background: Elastography is an imaging technique which has been used in the last decades and its role in breast masses characterization is well established. However, its value for predicting breast cancer grading is yet to be studied. Objective: To determine the role of strain elastography in the prediction of the grade of mammary ductal carcinoma. Methods: A cross sectional study enrolled 44 female patients with Breast Imaging Reporting and Data System (BI-RADS) Category 5 breast mass. Complete B-mode and elastographic ultrasound examination of the breast was performed with evaluation of the

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Mosavi, Zeinb, Haniyeh Bashi Zadeh Fakhar, Mostafa Rezaei-Tavirani, Mohamd Esmaeel Akbari, and Forouzan Rostami. "Proteome profiling of ductal carcinoma in situ." Breast Disease 41, no. 1 (2023): 513–20. http://dx.doi.org/10.3233/bd-220017.

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BACKGROUND AND AIM: DCIS is the most common type of non-invasive breast cancer, accounting for about 15 to 30%. Proteome profile is used to detect biomarkers in the tissues of breast cancer patients by mass spectrometry. This study aimed to obtain the expression profile of DCIS proteome, and the expression profile of invasive biomarkers, and finally to introduce a dedicated biomarker panel to facilitate the prognosis and early detection for in situ breast cancer patients. METHODS AND MATERIALS: In this study, 10 patients with breast cancer (DCIS) were studied. Benign (marginal) and cancerous t

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Navakodi, Manjula, and Yogesh Anbazhagan. "Histological Harmony: A Distinct Case of Mixed Breast Carcinoma in an Elderly Female." Asian Pacific Journal of Cancer Care 10, no. 1 (2025): 381–84. https://doi.org/10.31557/apjcc.2025.10.1.381-384.

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Background: Breast cancer is classified morphologically into “Invasive Breast Carcinoma of No Special Type” (IBC-NST) and various special subtypes. Mixed breast carcinoma, characterized by the presence of two or more distinct histological types, poses unique diagnostic challenges and is relatively rare. Case Presentation: A 74-year-old female presented with a six-month history of a lump in her left breast, with no significant family history. Clinical examination revealed an ill-defined lump, and imaging studies indicated a BIRADS score of IV-B. Fine Needle Aspiration Cytology (FNAC) suggested

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Al-Refai, Reham, Ahmed Bendari, Doaa Morrar, et al. "Immunohistochemical Staining Characteristics of Low-Grade Invasive Ductal Carcinoma Using the ADH5 Cocktail (CK5/14, P63, and CK7/18): A Potential Interpretative Pitfall." Diagnostics 13, no. 18 (2023): 2966. http://dx.doi.org/10.3390/diagnostics13182966.

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Background: In our practice, the antibody cocktail ADH5 (CK5/14, p63, and CK7/18) helps with diagnostic challenges, such as identifying microinvasion and foci of invasive carcinoma, differentiating atypical ductal hyperplasia from hyperplasia of the usual type, and distinguishing basal phenotypes in triple-negative carcinomas. However, the ADH5 cocktail does have pitfalls and caveats. Methods: We describe our experience with the ADH5 cocktail of antibodies in breast pathology. Institutional knowledge and a literature search form our data sources. Results: We analyzed 44 cases. Four out of a to

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Mandal, Meghadipa, and Anadi Roy Chowdhury. "Bilateral Pleomorphic Ductal Carcinoma Of Breast- A Rare Presentation With Its Diagnostic Dilemma." International Journal of Human and Health Sciences (IJHHS) 6, no. 2 (2022): 213. http://dx.doi.org/10.31344/ijhhs.v6i2.449.

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Pleomorphic carcinoma of breast is a rare morphological subtype of Invasive Breast Carcinoma No Special Type (IBC NST), which has histomorphological overlap with other entities. Here we present such a case with bilateral breast involvement in 45 years old nulliparous woman with family history of breast carcinoma. Typical numerous multinucleated cells (>50%) with marked pleomorphism and wide areas of necrosis were histopathological presentation. AE1/AE3 and Vimentin were positive. Ki-67 labelling index was high along with HER2 amplification. Important differentials were IBC NST with Osteocla

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Polyak, Kornelia. "Abstract IA035: DCIS to IDC progression - a key step of immune escape." Cancer Prevention Research 15, no. 12_Supplement_1 (2022): IA035. http://dx.doi.org/10.1158/1940-6215.dcis22-ia035.

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Abstract The cellular and molecular mechanisms underlying ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) transition are poorly understood. We have analyzed genetic, gene expression, epigenetic profiles of cells composing the tumor and identified cell type-specific changes during tumor progression. Importantly, we detected significant changes in the immune cell composition during tumor progression implying immune escape in invasive tumors and active adaptive immune response in DCIS. We demonstrate that these progression stage-specific alterations are also present in a rat mo

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Taunk, Khushman, Ravindra Taware, Tushar H. More, et al. "A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast." RSC Advances 8, no. 44 (2018): 25040–50. http://dx.doi.org/10.1039/c8ra02083c.

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Yu, Bao-Hua, Shao-Xian Tang, Xiao-Li Xu, et al. "Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions." Journal of Clinical Pathology 71, no. 6 (2018): 546–53. http://dx.doi.org/10.1136/jclinpath-2017-204751.

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AimsTo fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC).MethodsClinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed.ResultsOverall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misin

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Wanjara, Samuel, Siwillis Mithe, Moses Odhiambo Osoo, et al. "Molecular Subtypes of Receptor-defined Breast Cancer from Nakuru, Kenya." East and Central African Journal of Surgery 29, no. 2 (2021): 35–41. http://dx.doi.org/10.4314/ecajs.v29i2.7.

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Introduction The incidence of breast cancer in Sub-Saharan-Africa (SSA) is rising. Expression of hormone receptors and molecular-subtyping is paramount in rationalizing prognosis and therapy. There exists significant variation in molecular status of breast cancer in SSA. We aimed to describe the receptor status and molecular subtypes of breast cancer at our centre. Methods We conducted a retrospective study on patients with breast cancer enrolling for oncological care at our centre beginning May 2018 to December 2021. Results We included 345 patients with a median age of 49 years, 331 female a

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Buzenkova, A. V., L. A. Tashireva, M. V. Zavyalova, and V. M. Perelmuter. "The features of tumor niche cell composition in invasive breast ductal carcinoma of no special type." Siberian journal of oncology 21, no. 5 (2022): 59–68. http://dx.doi.org/10.21294/1814-4861-2022-21-5-59-68.

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Breast cancer is the most common cancer and the leading cause of cancer death in woman of childbearing age. Tumor progression depends on the character of stromal-parenchymal interactions. Tumor microenvironment exerts a key influence on tumor progression. Tumor niche is an important element of the tumor microenvironment. According to existing ideas, tumor niche consists on immune cells and bone marrow progenitor cells. The present study describes the parameters of tumor niche in invasive breast carcinoma of no special type (IC-NST), associated with lymph node metastases. The purpose of the stu

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Middleton, L. P. "Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type." Breast Diseases: A Year Book Quarterly 22, no. 2 (2011): 154–55. http://dx.doi.org/10.1016/j.breastdis.2011.03.060.

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