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Dissertations / Theses on the topic 'Invasive pneumococcal disease'

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Published: 4 June 2021

Last updated: 16 June 2025

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1

Sjöström, Karin. "Molecular epidemiology of pneumococcal carriage and invasive disease /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-094-7/.

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2

Ku, Cheng-Lung. "Human IRAK-4 deficiency and invasive pneumococcal disease." Paris 5, 2007. http://www.theses.fr/2007PA05T019.

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The susceptibility to severe Streptococcus pneumoniae is associated with a variety of human primary immunodeficiencies. Previous studies in human inherited defects showed several immune responses that were critical for this protection: antibody- and complement-mediated opsonization, the spleen and NF-KB-mediated immune responses. Recently, human Interleukin-l-receptor-associated-kinase-4 (IRAK-4) deficiency which presented a complete impairment in most Toll-like receptors' (TLRs) signaling was found and patients suffered from mostly pyogenic bacterial infections, especially caused by S. Pneumo

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3

Silva, Entrudo Fernandes Vitor. "Genetic basis of susceptibility to invasive pneumococcal disease." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/37467.

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Streptococcus pneumoniae (the pneumococcus) is a major cause of pneumonia, septicaemia and meningitis, particularly in high-risk groups such as children, the elderly and the immunocompromised. Host genetic factors play a significant role in susceptibility to pneumococcal disease. We have developed a mouse model of genetic susceptibility to invasive pneumococcal disease, with the purpose of identifying candidate disease genes. A panel of nine inbred mouse strains were screened in response to pneumococcal pneumonia infection and two strains emerged showing different phenotypes to the disease, th

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4

Coulibaly, Aissata. "Impact of Pneumococcal Conjugate Vaccine Thirteen Valent on the Reduction of Invasive Pneumococcal Disease." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2116.

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Many children under the age of 5 die each year of invasive pneumococcal disease. Childhood vaccination against this disease reduces morbidity and mortality. Despite the introduction of a pneumococcal conjugate vaccine (PCV13) in a central African country in 2011, all provinces have not yet been vaccinated. The purpose of this quantitative quasi-experimental study was to determine whether there was an association between the introduction of PCV13 and new cases of pneumococcal disease in 2 provinces in central Africa. The sample size for the study was 380. The theoretical framework for this stud

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5

Perez, Federico. "Challenges And Opportunities To Protect Veterans From Pneumococcal Disease: A “Virtual Clinic” Improves Vaccination." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1512685624555677.

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6

Nuorti, J. Pekka. "Epidemiology of invasive pneumococcal disease in adults : implications for prevention." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/nuorti/.

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7

Lin, Jiahuang, and 林佳璜. "A systematic review on the burden of invasive pneumococcal disease among adult in Asian populations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48424705.

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Invasive pneumococcal disease (IPD) coursed many deaths worldwide according to World Health Organization. Disease burden of IPD among adults were estimated in western countries. However, relative information is lacking in Asia, which occupies over 60% of global population. The objective of this review is to address the disease burden of IPD among adults in Asian and totally 15 articles was reviewed in this paper. The burden of IPD in Asia among adults is hard to estimate but generally in the high level. The highest case fatality rate was occurred in Taiwan about 30.2% in 2007. The most common

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8

Wadanambi, Arachchige Sanjay Harsha Jayasinghe. "Long-term impact and effectiveness of vaccines on invasive pneumococcal disease in Australian children." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20156.

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Pneumococcal disease is a leading cause of morbidity and mortality in children globally. Pneumococcal conjugate vaccines (PCVs), available since early 2000, had proven efficacy to prevent invasive pneumococcal disease (IPD)-the sever form of pneumococcal infections. For Australian children PCV had been publicly funded through the national immunisation program, initially in 2001 for those with increased disease risk which included Aboriginal and Torres Strait Islander children and from 2005 for all children. The schedule of PCV used in Australia comprising three doses at age 2, 4 and 6 months (

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9

Navarro, Torné Adoración. "European surveillance of invasive pneumococcal disease. Epidemiology, serotype distribution and antimicrobial resistance patterns." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/368572.

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Antecedentes Streptococcus pneumoniae es el agente causal de enfermedad grave, tanto en términos de morbilidad como mortalidad, tales como la enfermedad neumocócica invasiva (ENI), neumonía y enfermedades del tracto respiratorio superior que afectan principalmente a niños. Era previsible que la introducción de la vacuna neumocócica conjugada en Europa tuviera un impacto sobre la epidemiología de la enfermedad neumocócica invasiva. El estudio y evaluación de los cambios en la epidemiología de la enfermedad y las tendencias, en particular el desplazamiento de serotipos, la emergencia se nuevas

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10

Lee, Lai-ka, and 李勵嘉. "The pattern of invasive pneumococcal disease in Hong Kong, other parts of China, United States and Thailand : a focus on impact of pneumococcal vaccination : a systematic review." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206944.

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Objectives: By summarizing and comparing the pattern of invasive pneumococcal disease (IPD) in the 4 areas (namely Hong Kong, other parts of China, United States and Thailand) at different stages of implementation of universal pneumococcal vaccination, a snapshot picture could be obtained to visualize how pneumococcal vaccination has impacted upon various important measures, including the burden of IPD, prevalent serotypes, antimicrobial resistance, risk factors of IPD, to guide us on the next step to optimize our ability to combat against IPD. Methods: To achieve the objective, a systemati

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11

Jaccard, Ruedin Hélène. "Invasive meningococcal and pneumococcal disease in Switzerland : cost-utility analysis of different vaccine strategies /." Neuchâtel : [s.n.], 2003. http://www.public-health-edu.ch/new/Abstracts/JRH_02.06.03.pdf.

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12

Bricio, Moreno L. "Mechanisms of pathogenesis of African pneumococcal serotype 1 isolates during nasopharyngeal carriage and invasive disease." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3000751/.

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13

Coetzee, geb Schnappauf Christin. "Fragen und Antworten zu invasiven Pneumokokkenerkrankungen bei Kindern und Jugendlichen." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-182299.

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Background: S. pneumoniae is a major cause of meningitis, pneumonia and sepsis in children. In 2006 universal pneumococcal vaccination was recommended in Germany for all children up to their second birthday. We have compared the prevalence and outcome of IPD at a single hospital before and after the introduction of vaccination. Findings: 55 cases of IPD were identified over an 11 year period. Almost half of the patients were younger than 2 years of age. Most of the children were affected by pneumonia. The second highest incidence seen was for meningitis and sepsis. 17 patients exhibited additi

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14

Lees, John Andrew. "Host and pathogen genetics associated with pneumococcal meningitis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269395.

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Meningitis is an infection of the meninges, a layer of tissue surrounding the brain. In cases of pneumococcal meningitis (where the bacterium Streptococcus pneumoniae is the causat- ive agent) this causes severe inflammation, requiring intensive care and rapid antibiotic treatment. The contribution of variation in host and pathogen genetics to pneumococcal meningitis is unknown. In this thesis I develop and apply statistical genetics techniques to identify genomic variation associated with the various stages of pneumococcal meningitis, including colonisation, invasion and severity. I start by

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15

Drennon, Michael T. "Drug resistant patterns of invasive Streptococcus pneumoniae infections in the State of Florida in 2003." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001455.

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16

Rayner, Rachael E. "Investigating the population structure of Queensland invasive Streptococcus pneumoniae isolates in children: Using a modified multi-locus variable number of tandem repeat analysis and a novel minimum SNPs capsular typing method." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/87096/1/Rachael_Rayner_Thesis.pdf.

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This research investigated the use of DNA fingerprinting to characterise the bacteria Streptococcus pneumoniae or pneumococcus, and hence gain insight into the development of new vaccines or antibiotics. Different bacterial DNA fingerprinting methods were studied, and a novel method was developed and validated, which characterises different cell coatings that pneumococci produce. This method was used to study the epidemiology of pneumococci in Queensland before and after the introduction of the current pneumococcal vaccine. This study demonstrated that pneumococcal disease is highly prevalent

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17

Bahuaud, Mathilde. "Vaccination anti-pneumococcique chez les sujets à risque d'infections invasives à pneumocoques et prévention de l'hyporéponse Immunogenicity and persistence of the 13-valent pneumococcal conjugate vaccine (PCV13) in patients with untreated smoldering multiple myeloma (SMM): a pilot study Immunogenicity and persistence of a prime-boost re-vaccination strategy for pneumococcal vaccines in patients with rheumatoid arthritis Pneumococcal vaccination in patients with systemic lupus erythematosus: a multicenter placebo-controlled randomized double-blind study Prevention of hyporesponsiveness by modulation of schedule and doses of pneumococcal vaccine immunization." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB067.

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Deux vaccins sont actuellement disponibles pour la prévention des infections invasives à pneumocoques (IIP) : un vaccin polysaccharidique Pneumovax® (PPV23) et un vaccin conjugué Prevenar13® (PCV13), induisant respectivement une protection contre 23 et 13 sérotypes. Le PPV23 est considéré comme faiblement immunogène, en particulier chez les personnes âgées et les patients immunodéprimés. Le PCV13, en revanche, en raison de la conjugaison à une protéine porteuse, présente l'avantage d'induire une réponse immunitaire T-dépendante, non observée avec le vaccin PPV23. Dans notre travail nous avons

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18

Russo, Perniciaro Stephanie [Verfasser], Mark van der [Akademischer Betreuer] Linden, and Irene [Akademischer Betreuer] Burckhardt. "Spatial epidemiology of invasive pneumococcal disease isolates from children under six in Germany / Stephanie Russo Perniciaro ; Mark van der Linden, Irene Burckhardt." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1195150989/34.

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19

Galvão, Vivian Santos. "Caracterização de cepas de streptococcus pneumoniae causadoras de doença invasiva na cidade de Salvador, Bahia." Centro de Pesquisas Gonçalo Moniz, 2012. https://www.arca.fiocruz.br/handle/icict/7183.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2013-10-18T18:53:21Z No. of bitstreams: 1 Vivian Galvão. Caracterizaçao de cepas...2012.pdf: 1132531 bytes, checksum: c5a7374a74f6f74d8bd7cc7573c224f5 (MD5)<br>Made available in DSpace on 2013-10-18T18:53:21Z (GMT). No. of bitstreams: 1 Vivian Galvão. Caracterizaçao de cepas...2012.pdf: 1132531 bytes, checksum: c5a7374a74f6f74d8bd7cc7573c224f5 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil<br>A doença pneumocócica invasiva (DPI) continua sendo uma das pr

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20

Massaia, Irineu Francisco Delfino Silva. "Avaliação da resposta imune inata in situ no pulmão na doença pneumocócica invasiva." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-03112010-173911/.

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INTRODUÇÃO: A doença pneumocócica invasiva (DPI) tem alta mortalidade sendo o pulmão órgão de intenso acometimento. Na DPI caracterizou-se localmente importante processo inflamatório agudo com expressivo aumento de macrófagos, polimorfonucleares e fenômenos exsudativos como edema e hemorragia intra-alveolar. Concretizou-se uma resposta inflamatória proeminente com redução dos fenômenos de apoptose que se traduziu por aumento significativo de citocinas pró-inflamatórias, exceto IL-6 e IL-8, aumento de Toll-2, ativação do complemento, aumento de expressão de ICAM- 1 e CD 14 que em conjunto favor

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21

Selva, Jové Laura. "Real-time PCR per a la vigilància epidemiològica de la malaltia pneumocòccica invasiva (MPI) en pacients pediàtrics." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/92298.

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Streptococcus pneumoniae (S. pneumoniae) és un colonitzador habitual del tracte respiratori superior dels humans. Es tracta d’un patogen comú de l’espècie humana que presenta una elevada taxa de morbiditat i mortalitat arreu del món. El bacteri pot causar otitis mitjana, sinusitis o infeccions de tracte respiratori superior, (per contigüitat) però també pot causar malaltia invasiva, quan habita en un territori habitualment estèril, produint pneumònia, bacterièmia, septicèmies i meningitis, entre d’altres. La malaltia pneumocòccica és un important problema de salut pública i és la principal

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22

Svensson, Tobias. "Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention." Doctoral thesis, Uppsala universitet, Hematologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316461.

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The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS). Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. In a retrospective single institution study, we concluded that pure IgG subclass deficiency in

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23

Leggat, David Jason. "Immune response to Streptococcus pneumoniae polysaccharide vaccination and antigen-selected B cells in highly susceptible individuals." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1396613525.

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24

Bautista, Rodríguez Carles. "Relació entre la malaltia pneumocòccica invasiva i el dèficit genètic de MBL (mannose-binding lectin)." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/471529.

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INTRODUCCIÓ. La susceptibilitat a la malaltia pneumocòccica invasiva (MPI) es correlaciona amb l’edat i els nens són el grup amb major inicidéncia de malaltia. El paper del sistema immunològic innat, concretament la MBL (mannose-binding lectin) i la seva relació amb la MPI no està ben definit. OBJECTIUS. Els objectius d’aquesta tesi doctoral son determinar la prevalença de genotips responsables de nivells baixos de MBL sèrica en pacients amb MPI segons els grup d’edat i el potencial invasiu associat al serotip de pneumococ. MATERIAL I MÈTODE. Es realitzen dos estudis. El primer és un

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25

Winters, Meghan Lesley. "Antimicrobial resistance in invasive pneumococcal disease." Thesis, 2006. http://hdl.handle.net/2429/18354.

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Antimicrobial resistance in Streptococcus pneumoniae has increased in recent decades at a frightening pace. The infant conjugate vaccine program, introduced in BC in 2003, is a tool for the control of invasive pneumococcal disease (IPD) with substantial potential to combat antimicrobial resistance. The first phase of this thesis linked surveillance programs at the BC Centre for Disease Control and the National Centre for Streptococcus to evaluate recent trends in IPD incidence, serotype distribution, and antimicrobial resistance. Based on 1,288 reported cases of IPD over 2002-2005, there was a

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Paixão, Ana Laura. "The role of pneumococcal carbon metabolism in colonisation and invasive disease." Doctoral thesis, 2015. http://hdl.handle.net/10362/14841.

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Streptococcus pneumoniae is a common asymptomatic commensal of the human nasopharynx. However, it is better known as a threatening pathogen that causes serious diseases such as pneumonia, meningitis and sepsis, as well as other less severe but more prevalent infections (e.g. otitis media). With the increase of antibiotic resistance and the limited efficacy of vaccines, pneumococcal infections remain a major problem. Therefore, the discovery of new therapeutic targets and preventive drugs are in high demand.(...)<br>Fundação para a Ciência e a Tecnologia

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27

Chung, Hansol. "Prevalence of underlying risk factors among children with all-cause pneumonia in an urban setting." Thesis, 2015. https://hdl.handle.net/2144/16079.

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BACKGROUND: After the introduction of PCV7 and PCV13, the number of cases of pneumonia in children caused by vaccine serotypes has decreased significantly. Children with comorbidities, however, are still at high risk for IPD. This study aims to compare children with comorbidities to healthy children in an urban setting to assess current risk factors and potential risk factors for pneumonia. METHODS: Existing clinical data of Boston Medical Center patients under 7 years of age were used to compare age, gender, race, comorbidities, and immune status of children with pneumonia to those of chil

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Su, Wei-Ju, and 蘇韋如. "Post-licensure Vaccine Effectiveness Study of Pneumococcal Vaccines against Invasive Pneumococcal Disease in Children and Older Adults in Taiwan." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/g9h9m6.

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博士<br>國立臺灣大學<br>流行病學與預防醫學研究所<br>106<br>Background and Aims: There are limited evidence describing the post-licensure vaccine effectiveness (VE) of a combination of pneumococcal conjugate vaccines (PCVs) of different valences (7-valent PCV, PCV7/10-valent PCV, PCV10/13-valnt PCV, PCV13) and/or the duration of protection they offer against IPD in children. Additionally, most evidence identified 23-valent pneumococcal polysaccharide vaccine (PPV23) VE against IPD in adults comes from western counties. This study was to evaluate the PCV VE before PCV introduction into routine immunization in child

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Nyasulu, Peter Suwirakwenda. "Risk factors for mortality in patients with invasive pneumococcal disease in South Africa." Thesis, 2008. http://hdl.handle.net/10539/5084.

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ABSTRACT Introduction Invasive pneumococcal disease (IPD) is an important cause of morbidity and mortality in many parts of the world. It is estimated that pneumococcal disease causes more than one million-childhood deaths every year and the burden of disease is greater in developing countries. The main aim of this study was to analyze risk factors associated with mortality in invasive pneumococcal disease in all ages in South Africa. Materials and Methods We performed an analytical cross-sectional analysis of secondary data from national population-based surveillance for invasive St

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Ya-huiShen and 沈雅慧. "Changing epidemiologic pattern of invasive pneumococcal disease among children in Taiwan: Implications for vaccine program." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/27850533387486912903.

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碩士<br>國立成功大學<br>公共衛生研究所<br>98<br>Pneumonia is the most common infectious disease among children under 5 years old and elderly over 65 years old. According to the report from WHO, pneumonia is the most common cause of death in children less than 5 years of age. However, 30 to 50% of pneumonia cases resulted from Streptococcus pneumonia infection. Except pneumonia, Streptococcus pneumonia was responsible for meningitis, septicemia, and empyema, which collected into invasive pneumococcal disease (IPD). Antibiotics is not the only way to treat or to eradicate pneumococcal disease. 7-valent pneumo

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Fumbatha, Sinethemba. "Development of novel hypervalent iodine conjugation strategies towards pneumococcal conjugate vaccines." 2013. http://hdl.handle.net/11394/3551.

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Masters of Science<br>Invasive pneumococcal disease (IPD), which includes potentially fatal conditions such as meningitis, septicaemia and pneumonia poses a threat in children aged <5 years, pneumonia being the leading cause of child mortality worldwide. Even though capsular polysaccharides are the main antigens involved in the immunity to encapsulated bacteria, it was found that in children in that age group, the immune system was unresponsive. Conjugate vaccines however induce immunologic memory and provide long-term protective immunity. Therefore the aim of this project was to develop nove

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Malo, Jonathan Andrew. "Communicable Disease Applied Epidemiology in Queensland." Master's thesis, 2017. http://hdl.handle.net/1885/142364.

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The Communicable Diseases Branch (CDB) of Queensland Health has the role of protecting the health of Queenslanders through the monitoring, surveillance, and control of communicable diseases. From February 2016 to December 2017, I undertook a field placement within the CDB. This thesis details projects undertaken during this 22-month field placement. The projects comprise an investigation of a Q fever outbreak at an animal refuge clinic and veterinary clinic, the establishment of a surveillance system to identify newly acquired hepatitis C infections

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Teodoro, Inês Maria Marques. "Pneumococcal invasive disease in adults (2015-2017): epidemiological and molecular characterization of Streptococcus pneumoniae and genomic analysis of emerging clones." Master's thesis, 2020. http://hdl.handle.net/10451/51878.

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Tese de mestrado, Microbiologia Clínica e Doenças Infecciosas Emergentes, Universidade de Lisboa, Faculdade de Medicina, 2020<br>The introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) for children in Portugal resulted in significant changes in the serotype distribution of the pneumococcal population responsible for invasive pneumococcal disease (IPD) not only in children, but also in adults, consistent with herd protection. A 23-valent pneumococcal polysaccharide vaccine (PPV23) is also available in Portugal since 1996, although adult uptake is believed to be low. The effect

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Teodoro, Inês Maria Marques 1996. "Pneumococcal invasive disease in adults (2015-2017) : epidemiological and molecular characterization of Streptococcus pneumoniae and genomic analysis of emerging clones." Master's thesis, 2020. http://hdl.handle.net/10451/46374.

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Tese de mestrado, Microbiologia Clínica e Doenças Infeciosas Emergentes, Universidade de Lisboa, Faculdade de Medicina, 2020<br>The introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) for children in Portugal resulted in significant changes in the serotype distribution of the pneumococcal population responsible for invasive pneumococcal disease (IPD) not only in children, but also in adults, consistent with herd protection. A 23-valent pneumococcal polysaccharide vaccine (PPV23) is also available in Portugal since 1996, although adult uptake is believed to be low. The effect o

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Coetzee, geb Schnappauf Christin. "Fragen und Antworten zu invasiven Pneumokokkenerkrankungen bei Kindern und Jugendlichen." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13589.

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Background: S. pneumoniae is a major cause of meningitis, pneumonia and sepsis in children. In 2006 universal pneumococcal vaccination was recommended in Germany for all children up to their second birthday. We have compared the prevalence and outcome of IPD at a single hospital before and after the introduction of vaccination. Findings: 55 cases of IPD were identified over an 11 year period. Almost half of the patients were younger than 2 years of age. Most of the children were affected by pneumonia. The second highest incidence seen was for meningitis and sepsis. 17 patients exhibited additi

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Thompson, Craig K. "Applied Epidemiology of Vaccine Preventable Diseases and Outbreaks in New South Wales." Master's thesis, 2016. http://hdl.handle.net/1885/135768.

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The National Centre for Immunisation Research and Surveillance (NCIRS) is located within the Kids Research Institute (KRI) at Westmead Children’s Hospital. It is somewhat hidden away from the children’s hospital, and no easier to navigate internally once you find the building on your first day. During my two years there, I was part of the Coverage, Evaluation and Surveillance (CES) Program Stream, which met monthly to discuss achievements and deliverables of the group. As an active member, I was encouraged to keep the group up to date on my progress thro

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Marmor, Alexandra Mary. "Thesis Submitted for the Degree of Master of Philosophy in Applied Epidemiology." Master's thesis, 2017. http://hdl.handle.net/1885/141155.

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My field placement for Master of Philosophy in Applied Epidemiology (MAE) program was with the Indigenous Health Division of the Australian Government Department of Health, and it provided opportunities for epidemiological training in a broad range of contexts. I present four projects to fulfil the core requirements of the MAE. I participated in a retrospective investigation into cases of carbapenemase-producing Enterobacteriaceae (CPE) identified over a four year period in the Australian Capital Territory. In this investigation I collecte

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Queirós, Miguel Ângelo Teixeira. "Pneumococcal adaptation: from colonization to disease." Master's thesis, 2019. http://hdl.handle.net/10451/41696.

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Tese de mestrado, Biologia Molecular e Genética, Universidade de Lisboa, Faculdade de Ciências, 2019<br>Streptococcus pneumoniae (pneumococcus) is a Gram-positive colonizer of the human nasopharynx. It is also responsible for several diseases such as pneumonia, bacteremia and meningitis. The transition from asymptomatic colonization to disease is accompanied by drastic changes in the host physiological conditions such as temperature, nutrient availability and pH, and in the mode of growth of the pathogen – from biofilm to planktonic (in case of invasive disease). The pneumococcal within-host a

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PODLENOVÁ, Kateřina. "Míra informovanosti a postoje rodičů k nadstandardnímu očkování dětí 0-3 roky v městě Příbram." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-156409.

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This thesis is concerned with the level of parents´ awareness and attitudes to above-standard vaccination of children from 0-3 years in Příbram. Among the optional vaccination of children from 0-3 years belong vaccination against pneumococcal disease, rotavirus infections, meningococcal invasive disease (caused by meningococcal of group C, A+C, or A, C, W 135 and Y, now also of group B), tick-borne encephalitis, varicella smallpox, influenza and hepatitis A (or a combination of type A + B). The first part deals with the issue in a theoretical perspective. It foreshadows the basic characteristi

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Harvey, Richard Manuel. "Genetic characterisation of Streptococcus pneumoniae serotype 1 isolates in relation to invasiveness." Thesis, 2010. http://hdl.handle.net/2440/67243.

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Streptococcus pneumoniae (the pneumococcus) is one of the most significant causes of human mortality and morbidity, and is a leading cause of diseases such as pneumonia, invasive disease (including bacteraemia and meningitis [IPD]) and otitis media. However, the pneumococcus is more commonly carried asymptomatically within the nasopharynx. The likelihood of the pneumococcus progressing from asymptomatic carriage to IPD varies between strains, and is associated with certain serotypes and clones. In particular, serotype 1 strains have a high-attack rate as they readily progress from a state of t

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