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Journal articles on the topic 'Investigative utility'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Satin, Geri E., and Ronald P. Fisher. "Investigative utility of the Cognitive Interview: Describing and finding perpetrators." Law and Human Behavior 43, no. 5 (2019): 491–506. http://dx.doi.org/10.1037/lhb0000326.

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2

Benson, Mairi S., and Martine B. Powell. "Australian prosecutors’ perceptions of the utility of child investigative interview protocols." International Journal of Police Science & Management 17, no. 4 (2015): 216–29. http://dx.doi.org/10.1177/1461355715616958.

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Кузьмина and Alena Kuzmina. "Profiling in the activities of the Internal Affairs of Russia." Applied psychology and pedagogy 1, no. 3 (2016): 4. http://dx.doi.org/10.12737/21845.

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The article: is devoted to the possibilities of using profiling in law enforcement police. Many years of successful experience in the use of profiling abroad, obtained positive results confirm the practical utility of this method in the preparation of the police, and can be used in the training of operational-investigative and operative search units, public security police, Police psychologists and investigative units.

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4

Malmquist, J., and G. Birgerstam. "Assays of pancreatic B cell secretory products: Utility in investigative and clinical diabetology." Scandinavian Journal of Clinical and Laboratory Investigation 46, no. 8 (1986): 705–13. http://dx.doi.org/10.3109/00365518609084041.

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Sia, Chin Lan, and Suliman Al-Hawamdeh. "Taxonomy-Building Tools: An Investigative Study." Journal of Information & Knowledge Management 02, no. 01 (2003): 63–77. http://dx.doi.org/10.1142/s0219649203000267.

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Creating topic hierarchies that can be mapped to the source documents provide effective access to the required information. However, the exponential growth in the volume of information may be too overwhelming for manual approach to taxonomy building. Taxonomy software, with automated approach, but minimal human intervention, easy integration with other products, and effective taxonomy maintenance utility provide a practical and efficient solution. Many vendors serving this market segment offer a wide range of approaches and solutions, such as Semio, Autonomy, Verity, Quiver, Inxight, and Smart

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Schiappa, Tamra A. "Teaching Through Investigative Case Studies: Lessons from Invertebrate Paleontology." Paleontological Society Special Publications 12 (2012): 169–80. http://dx.doi.org/10.1017/s2475262200009308.

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Students in traditional invertebrate paleontology courses typically are required to identify, sketch morphologic features, and memorize chronostratigraphic ranges of major fossil taxa. This traditional approach is viewed as mundane and unnecessary by many students. Integrating new learning strategies involving specific case studies into an invertebrate paleontology course creates a dynamic learning environment. This improves students' observational and critical-thinking skills as well as their understanding of the utility of the fossil record and key geologic concepts. New teaching strategies,

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Growette Bostaph, Lisa, Laura L. King, and Patrick Q. Brady. "How victim credibility and cooperation influence investigative decision-making: examining DOJ's gender bias principles for investigating domestic and sexual violence." Policing: An International Journal 44, no. 4 (2021): 612–27. http://dx.doi.org/10.1108/pijpsm-02-2021-0018.

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PurposeThe purpose of this exploratory study is to examine if and how victim credibility affects investigative decision-making and case outcomes in domestic violence and sexual assault reports through the use of the US Department of Justice's Gender Bias Principles (GBPs).Design/methodology/approachThe authors conducted a content analysis of 370 DVSA police reports from one agency in the western US. Multivariate regression models were estimated to examine the relationships among victim credibility and investigative activities, victim cooperation and case clearance.FindingsVictim credibility si

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Mozova, Katarina. "Investigative challenges relating to gang-related homicide: senior investigating officers’ perspectives." Journal of Criminological Research, Policy and Practice 5, no. 3 (2019): 189–201. http://dx.doi.org/10.1108/jcrpp-04-2019-0024.

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Purpose The purpose of this paper is to provide the reader with senior investigating officer (SIO) perspectives of their understanding of gang-related homicide and associated investigative challenges. Design/methodology/approach A phenomenological design was utilised in this study. In sum, 15 SIOs from the Metropolitan Police Service were interviewed using a semi-structured interview and analysed using thematic analysis. Findings It was found that the original typology of “gang homicide” might be too narrow and focus should be paid to “gang-related homicide”, characterised via motive behind th

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Tadei, Alessandro, Johan Pensar, Jukka Corander, Katarina Finnilä, Pekka Santtila, and Jan Antfolk. "A Bayesian Decision-Support Tool for Child Sexual Abuse Assessment and Investigation." Sexual Abuse 31, no. 4 (2017): 374–96. http://dx.doi.org/10.1177/1079063217732791.

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In assessments of child sexual abuse (CSA) allegations, informative background information is often overlooked or not used properly. We therefore created and tested an instrument that uses accessible background information to calculate the probability of a child being a CSA victim that can be used as a starting point in the following investigation. Studying 903 demographic and socioeconomic variables from over 11,000 Finnish children, we identified 42 features related to CSA. Using Bayesian logic to calculate the probability of abuse, our instrument—the Finnish Investigative Instrument of Chil

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Bichler, Gisela, Steven Lim, and Edgar Larin. "Tactical Social Network Analysis: Using Affiliation Networks to Aid Serial Homicide Investigation." Homicide Studies 21, no. 2 (2016): 133–58. http://dx.doi.org/10.1177/1088767916671351.

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Integrating crime pattern theory with tenets of social network theory, we argue that linking people who frequent the same places reveals intersecting behavioral patterns illustrative of case connectivity. Using the Green River serial murder investigation as a case study, we demonstrate that structural statistics may be useful in focusing investigative efforts. Significant shifts in the centrality of suspects emerge when we track the evolution of this case at 6-month increments, suggesting that the initial working case hypothesis misled investigators. Continued exploration into the utility of s

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11

Constantinidou, A., S. A. Afuwape, L. Linsell, et al. "Informational needs of patients with melanoma and their views on the utility of investigative tests." International Journal of Clinical Practice 63, no. 11 (2009): 1595–600. http://dx.doi.org/10.1111/j.1742-1241.2009.02096.x.

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12

Bruno, Alessandra M., Scott R. Cleary, Adam E. O'Leary, Michael C. Gizzi, and Christopher C. Mulligan. "Balancing the utility and legality of implementing portable mass spectrometers coupled with ambient ionization in routine law enforcement activities." Analytical Methods 9, no. 34 (2017): 5015–22. http://dx.doi.org/10.1039/c7ay00972k.

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Ambient sampling, portable MS systems have the potential to allow field processing of forensic evidence, as well as serve as a flexible investigative tool during law enforcement activities. However, the underlying legal implications require the discretion of practitioners to ensure both lawful and ethical usage.

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Trammell, Lindsay, Chelsey Juarez, and Cris Hughes. "Commingled and Unprovenanced: A Case Study Highlighting the Utility of Multiple Techniques for Testing Investigative Leads." Forensic Anthropology 2, no. 1 (2018): 105–16. http://dx.doi.org/10.5744/fa.2018.0011.

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14

Siviy, Stephen M. "It still takes at least two to tango." Behavioral and Brain Sciences 23, no. 2 (2000): 264–65. http://dx.doi.org/10.1017/s0140525x00392433.

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The target article provides a useful investigative model for studying social behaviors, but it falls short of establishing a more comprehensive conceptual framework for understanding complex social inter- actions. Social behaviors such as play involve a dynamic and complex interplay between two or more organisms. Even when feed-forward mechanisms are taken into account and the model is anchored to evolutionary theory, the utility of this model is still limited by the conspicuous absence of neurobiological theory and data.

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Purwanto, Edi, and Agnes Debora Bernice Purwanto. "AN INVESTIGATIVE STUDY ON SUSTAINABLE COMPETITIVE ADVANTAGE OF MANUFACTURE COMPANIES IN INDONESIA." Business: Theory and Practice 21, no. 2 (2020): 633–42. http://dx.doi.org/10.3846/btp.2020.12256.

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The purpose of the research is to investigate the effect of external and internal factors on corporate performance and sustainable competitive advantage. The samples of the study are ten manufacturing companies in the pharmaceutical, cosmetic, and household utility sectors listed on the Indonesia Stock Exchange (IDX). The data analysis use PLS-SEM. The result shows that corporate performance is influenced by leverage and liquidity (internal factors) significantly but is not influenced by external factors significantly as well as organizational performance doesn’t impact the sustainable competi

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Dalton, J. "Performance-based contract for non-revenue water reduction – case study Bahrain." Water Supply 19, no. 4 (2018): 1073–79. http://dx.doi.org/10.2166/ws.2018.159.

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Abstract A performance-based contract (PBC) for non-revenue water (NRW) reduction was executed in the Muharraq Governorate of the Kingdom of Bahrain between 2013 and 2016. The contract included a mixture of fixed and performance-based payment terms. The performance element included the establishment of 35 District Metered Areas (DMAs) and the targeted reduction of NRW by 15 percentage points within the project catchment. The contract was a partnership between the contractor and the utility, whereby the contractor undertook the investigative work, while the utility was responsible for executing

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Wallace, Robert B., and Sheldon M. Retchin. "A Geriatric and Gerontologic Perspective on the Effects of Medical Conditions on Older Drivers: Discussion of Waller." Human Factors: The Journal of the Human Factors and Ergonomics Society 34, no. 1 (1992): 17–24. http://dx.doi.org/10.1177/001872089203400103.

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In discussing Waller's paper, we build on his review of medical conditions and the risk of motor vehicle accidents (MVAs) using principles derived from geriatrics, gerontology, and health services research. Three approaches are suggested. The medical model uses discrete diseases as risk factors, but despite its utility and appeal, this model does not sufficiently characterize health and functional status to be the sole approach, and future investigative efforts should at least consider severity of illness concepts. The functional status model emphasizes a functional and physiological approach

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Beauregard, Eric, Irina Busina, and Jay Healey. "Confessions of sex offenders: extracting offender and victim profiles for investigative interviewing." Journal of Criminal Psychology 7, no. 1 (2017): 13–28. http://dx.doi.org/10.1108/jcp-10-2016-0031.

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Purpose Although offender profiling has been cited as an effective tool to interview suspects, empirical profiling methods have completely excluded interviewing suggestions when testing the validity of this technique. The purpose of this paper is to explore the utility of empirically derived profiles of offender- and victim-related sexual assault case characteristics (n=624) in the preparation of the interrogation strategies in sexual assault investigations. Design/methodology/approach Latent class analysis was used to extract profiles of offender- and victim-related sexual assault case charac

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Ludwikowski, Wyndolyn M. A., Patrick I. Armstrong, and Daniel G. Lannin. "Explaining Gender Differences in Interests." Journal of Career Assessment 26, no. 2 (2017): 240–57. http://dx.doi.org/10.1177/1069072717692743.

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This study integrated Holland’s themes within a modified social cognitive career theory (SCCT) model, exploring whether gender-related personality variables account for the relations between gender and vocational interests. Undergraduates ( N = 452) completed expressiveness, instrumentality, and realistic, investigative, artistic, social, enterprising, and conventional (RIASEC)-based measures of learning experiences, self-efficacy, and interests. Through structural equation modeling, the paths via expressiveness and instrumentality fully explained gender’s effect on artistic and conventional i

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Gardner, Michael, Nitesh Katta, Ayesha Rahman, Henry Rylander, and Thomas Milner. "Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography." Applied Sciences 8, no. 11 (2018): 2159. http://dx.doi.org/10.3390/app8112159.

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Optical coherence tomography (OCT), an optical imaging approach enabling cross-sectional analysis of turbid samples, is routinely used for retinal imaging in human and animal models of diseases affecting the retina. Scattering angle resolved (SAR-)OCT has previously been demonstrated as offering additional contrast in human studies, but no SAR-OCT system has been reported in detail for imaging the retinas of mice. An optical model of a mouse eye was designed and extended for validity at wavelengths of light around 1310 nm; this model was then utilized to develop a SAR-OCT design for murine ret

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Kakkar, Aanchal, Sandeep R. Mathur, Deepali Jain, Venkateswaran K. Iyer, Aasma Nalwa, and Mehar C. Sharma. "Utility of DOG1 Immunomarker in Fine Needle Aspirates of Gastrointestinal Stromal Tumor." Acta Cytologica 59, no. 1 (2015): 61–67. http://dx.doi.org/10.1159/000370057.

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Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. DOG1 is a sensitive and specific immunohistochemical marker for the diagnosis of GIST. To date, no study has reported the utility of DOG1 immunocytochemistry on aspirate smears. Methods: Aspirates with a cytological diagnosis of GIST were retrieved. DOG1 immunocytochemistry was performed on aspirates with adequate material. Results: 23 cases were included (11 primary, 2 recurrent, 10 metastatic). Primary tumors were most frequently located in the stomach; most metastatic tumors

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Bitzer, Sonja, Nicola Albertini, Eric Lock, Olivier Ribaux, and Olivier Delémont. "Utility of the clue — From assessing the investigative contribution of forensic science to supporting the decision to use traces." Science & Justice 55, no. 6 (2015): 509–13. http://dx.doi.org/10.1016/j.scijus.2015.05.005.

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Lasslett, Kristian. "Uncovering the Transnational Networks, Organisational Techniques and State-Corporate Ties Behind Grand Corruption: Building an Investigative Methodology." International Journal for Crime, Justice and Social Democracy 6, no. 4 (2017): 29–54. http://dx.doi.org/10.5204/ijcjsd.v6i4.445.

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While grand corruption is a major global governance challenge, researchers notably lack a systematic methodology for conducting qualitative research into its complex forms. To address this lacuna, the following article sets out and applies the corruption investigative framework (CIF), a methodology designed to generate a systematic, transferable approach for grand corruption research. Its utility will be demonstrated employing a case study that centres on an Australian-led megaproject being built in Papua New Guinea’s capital city, Port Moresby. Unlike conventional analyses of corruption in Pa

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Beckstead, J. H. "Optimal antigen localization in human tissues using aldehyde-fixed plastic-embedded sections." Journal of Histochemistry & Cytochemistry 33, no. 9 (1985): 954–58. http://dx.doi.org/10.1177/33.9.4020104.

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Although the utility of antigen labeling techniques in frozen tissues is well known, it is generally acknowledged that an improvement in morphologic preservation is desirable. Conventionally processed paraffin-embedded tissues are limited in the range of antigens that can be detected and newer plastic embedding techniques have been even more restricted. By using cold (4 degrees C) processing and limited fixation a wide range of antigens (including T and B markers) has been demonstrated in 2 mu plastic sections. The morphologic preservation and antigen localization are superior to other techniq

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Austin, Cynthia A., Stephen F. Finn, Timothy Z. Keith, Deborah J. Tharinger, and April D. Fernando. "The Parent Experience of Assessment Scale (PEAS): Development and Relation to Parent Satisfaction." Assessment 25, no. 7 (2016): 929–41. http://dx.doi.org/10.1177/1073191116666950.

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This study outlines the development of the Parent Experience of Assessment Scale (PEAS), which is based on principles of Therapeutic Assessment. The study includes pilot testing of a 64-item questionnaire across 134 participants, with psychometric analyses utilizing confirmatory factor analysis. The revised version consists of 24 items across five subscales with appropriate internal consistency reliability (alphas from .76 to .88). The PEAS demonstrates statistically significant relations with general parent satisfaction, with two subscales indicating significant direct effects via structural

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Aggarwal, Ankita, and Chandan Jyoti Das. "Contrast-enhanced ultrasound in evaluation of adrenal lesions with CT/MRI correlation." British Journal of Radiology 94, no. 1120 (2021): 20201170. http://dx.doi.org/10.1259/bjr.20201170.

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Most of the adrenal masses are incidentally detected. Multiphasic CT forms the mainstay for diagnosis and characterization of adrenal masses. MRI can further be used if the masses are indeterminate on CT scan. But as these investigations are expensive with risk of radiation exposure, contrast-enhanced ultrasound (CEUS) is currently under evaluation to assess its utility to act as a screening modality to differentiate benign vs malignant adrenal masses This investigative modality is relatively safe and can be used in patients having renal dysfunction or allergy to CT contrast. We, hereby, prese

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Kong, Nathan W., William R. Gibb, and Matthew C. Tate. "Neuroplasticity: Insights from Patients Harboring Gliomas." Neural Plasticity 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/2365063.

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Neuroplasticity is the ability of the brain to reorganize itself during normal development and in response to illness. Recent advances in neuroimaging and direct cortical stimulation in human subjects have given neuroscientists a window into the timing and functional anatomy of brain networks underlying this dynamic process. This review will discuss the current knowledge about the mechanisms underlying neuroplasticity, with a particular emphasis on reorganization following CNS pathology. First, traditional mechanisms of neuroplasticity, most relevant to learning and memory, will be addressed,

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Lees, C., A. Clark, A. Walkden, J. Satsangi, and I. Arnott. "S35 Clinical utility of faecal calprotectin in diagnosing IBD during first presentation to the gastroenterology clinic: A novel investigative algorithm." Journal of Crohn's and Colitis Supplements 4, no. 1 (2010): 32. http://dx.doi.org/10.1016/s1873-9954(10)70062-8.

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Savastano, Marcello, Monica Calderaro, and Giulia Maestoso. "Criminological and investigative analysis of sexual vicious behaviour." Rivista di Psicopatologia Forense, Medicina Legale, Criminologia 22, no. 1-2-3 (2017): 7–21. http://dx.doi.org/10.4081/psyco.2017.8.

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The following work is going to treat assembling main studies about the topic, the criminological analysis of sexual vicious behavior, outcome of a research led within a Master’s contest about “Criminology, investigative and strategic sciences for security”, by the Unitelma Sapienza University of Rome. The number of victims caused by this peculiar aberration of human behavior, per year, is comparable to a war: even though, of the latter one, shares only a subtle gradient of aggressiveness, produced or linked with sexual choices and not relating to more socially-elaborated frames, growth out to

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Zhang, Xudong, and Don B. Chaffin. "Task Effects on Three-Dimensional Dynamic Postures during Seated Reaching Movements: An Investigative Scheme and Illustration." Human Factors: The Journal of the Human Factors and Ergonomics Society 39, no. 4 (1997): 659–71. http://dx.doi.org/10.1518/001872097778667924.

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In this paper we describe a new scheme for empirically investigating the effects of task factors on three-dimensional (3D) dynamic postures during seated reaching movements. The scheme relies on an underlying model that integrates two statistical procedures: (a) a regression description of the relationship between the time-varying hand location and postural angles to characterize the movement data and (b) a series of analyses of variance to test the hypothesized task effects using representative instantaneous postures. The use of this scheme is illustrated by an experiment that examines two ge

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Clark, Annalie, Andrew Walkden, Jack Satsangi, Ian D. Arnott, and Charles W. Lees. "M1240 Clinical Utility of Faecal Calprotectin in Diagnosing Organic Disease During First Presentation to the Gastroenterology Clinic: A Novel Investigative Algorithm." Gastroenterology 138, no. 5 (2010): S—361—S—362. http://dx.doi.org/10.1016/s0016-5085(10)61666-6.

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Wineland, Adam, Yue Chen, Brian Boland, Kevin Chan, and Zion Tse. "Magnetic Resonance Conditional Microinjector." Journal of Imaging 5, no. 1 (2018): 4. http://dx.doi.org/10.3390/jimaging5010004.

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Glaucoma, one of the leading causes of blindness, has been linked to increases in intraocular pressure. In order to observe and study this effect, proposed is a specialized microinjector and driver that can be used to inject small amounts of liquid into a target volume. Magnetic resonance imaging (MRI) guided remotely activated devices require specialized equipment that is compatible with the MR environment. This paper presents an MR Conditional microinjector system with a pressure sensor for investigating the effects of intraocular pressure (IOP) in near-real-time. The system uses pressurized

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NASER, A. M., M. J. HOSSAIN, H. M. S. SAZZAD, et al. "Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens: an example of Nipah virus surveillance in Bangladesh." Epidemiology and Infection 143, no. 9 (2014): 1922–30. http://dx.doi.org/10.1017/s0950268814002635.

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SUMMARYThis paper explores the utility of cluster- and case-based surveillance established in government hospitals in Bangladesh to detect Nipah virus, a stage III zoonotic pathogen. Physicians listed meningo-encephalitis cases in the 10 surveillance hospitals and identified a cluster when ⩾2 cases who lived within 30 min walking distance of one another developed symptoms within 3 weeks of each other. Physicians collected blood samples from the clustered cases. As part of case-based surveillance, blood was collected from all listed meningo-encephalitis cases in three hospitals during the Nipah

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Sbeit, Wisam, Anas Kadah, Amir Mari, Mahmud Mahamid, and Tawfik Khoury. "A Comprehensive Narrative Review on the Evolving Role of Endoscopic Ultrasound in Focal Solid Liver Lesions Diagnosis and Management." Diagnostics 10, no. 9 (2020): 688. http://dx.doi.org/10.3390/diagnostics10090688.

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The implications of endoscopic ultrasound (EUS) have expanded considerably in recent years to cover more fields in invasive gastroenterology practice, as both an investigative and therapeutic modality. The utility of EUS in the diagnosis and management of focal liver lesions has gained a special attractiveness recently. The EUS probe proximity to the liver and its excellent spatial resolution enables real-time images coupled with several enhancement techniques, such as contrast-enhanced (CE) EUS. Aside from its notable capability to execute targeted biopsies and therapeutic interventions, EUS

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Lu, Y., J. G. Pouget, O. A. Andreassen, et al. "Genetic risk scores and family history as predictors of schizophrenia in Nordic registers." Psychological Medicine 48, no. 7 (2017): 1201–8. http://dx.doi.org/10.1017/s0033291717002665.

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AbstractBackgroundFamily history is a long-standing and readily obtainable risk factor for schizophrenia (SCZ). Low-cost genotyping technologies have enabled large genetic studies of SCZ, and the results suggest the utility of genetic risk scores (GRS, direct assessments of inherited common variant risk). Few studies have evaluated family history and GRS simultaneously to ask whether one can explain away the other.MethodsWe studied 5959 SCZ cases and 8717 controls from four Nordic countries. All subjects had family history data from national registers and genome-wide genotypes that were proces

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Singh, Ragini D., Haridas Nilayangode, Jayendra B. Patel, et al. "Combined Evaluation of Matrix Metalloproteinases and their Inhibitors has Better Clinical Utility in Oral Cancer." International Journal of Biological Markers 26, no. 1 (2011): 27–36. http://dx.doi.org/10.5301/jbm.2011.6359.

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Background Oral cancer is a major health hazard worldwide with increasing incidence and mortality. Cervical lymph node metastasis is a major determinant of outcome in oral cancer. The matrix metalloproteinase (MMP) system is critically involved in invasion and metastasis. Assessment of MMPs and tissue inhibitors of MMPs (TIMPs) in certain combinations might have better clinical efficacy given their potential role in the metastatic process. Aim Plasma concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 in 50 controls and 75 oral cancer patients (nonmetastatic, n=54; metastatic, n=21) were evaluat

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Shaw, Leslie M., Magdalena Korecka, Michal Figurski, et al. "Detection of Alzheimer Disease Pathology in Patients Using Biochemical Biomarkers: Prospects and Challenges for Use in Clinical Practice." Journal of Applied Laboratory Medicine 5, no. 1 (2019): 183–93. http://dx.doi.org/10.1373/jalm.2019.029587.

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Abstract Background Thirty-four years ago, amyloid-β 1-42 peptide was identified in amyloid plaques from brain tissue obtained from patients with Alzheimer disease (AD) and Down syndrome. This finding led to development of immunoassays for this marker of amyloid plaque burden in cerebrospinal fluid (CSF) approximately 10 years later. Subsequently, research immunoassays were developed for total τ protein and τ phosphorylated at the threonine 181 position. Subsequent studies documented the clinical utility of these biomarkers of amyloid plaque burden or τ tangle pathology in cohorts of living pa

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Cartwright, Joanna, W. Colin Duncan, Hilary O. D. Critchley, and Andrew W. Horne. "Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities." REPRODUCTION 138, no. 1 (2009): 9–22. http://dx.doi.org/10.1530/rep-09-0060.

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Ectopic pregnancy remains a considerable cause of maternal morbidity and mortality worldwide. Currently, it is diagnosed using a combination of transvaginal ultrasound and serial serum β-human chorionic gonadotrophin levels. Diagnosis is often delayed and these tests are time-consuming and costly, both psychologically to the patient and financially to health services. The development of a biomarker that can differentiate a tubal ectopic from an intrauterine implantation is therefore important. In the pre-genomic era, a one-by-one scientific approach has revealed over 20 candidate biomarkers th

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Sharma, Upender, Ajit Singh, Hemlata T. Kamra, Atul Beniwal, and Sonam Sharma. "Assessment of Utility of Fine Needle Aspiration Cytology in Patients of Peripheral Lymphadenopathy- Experience of A Tertiary Care Hospital." Annals of Pathology and Laboratory Medicine 8, no. 8 (2021): A196–200. http://dx.doi.org/10.21276/apalm.3113.

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Background: Fine needle aspiration cytology (FNAC) is a quick, sensitive, safe, reliable and cost-effective outdoor procedure that has a lower risk of complications as compared to a surgical biopsy. This study was conducted to analyse the various cytomorphological patterns establishing the diagnosis on FNAC in peripheral lymphadenopathy patients along with their clinical presentation.Methods: This study included 300 patients of peripheral lymphadenopathy in a tertiary care hospital of north-central Haryana. FNAC was done under all aseptic conditions and various cytomorphological patterns were

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Nguyen, Henry H., Robert Bechara, William G. Paterson, and Lawrence C. Hookey. "Two-year retrospective analysis of patients undergoing direct to procedure flexible sigmoidoscopy investigation with rectal bleeding as a primary complaint." Endoscopy International Open 06, no. 08 (2018): E1059—E1064. http://dx.doi.org/10.1055/a-0600-2157.

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Abstract Background and aims Rectal bleeding affects ~15 % of the general population and is a common reason for referral to gastroenterologists by primary care physicians. Direct to procedure flexible sigmoidoscopy is an appealing modality to investigate rectal bleeding due its diagnostic yield, safety profile, and accessibility. Patients referred on a routine basis for direct to procedure clinic by primary care physicians with the sole complaint of rectal bleeding have not previously been studied. Our study aims to explore the spectrum of diagnoses and evaluate for potential clinical predicto

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Papachristidis, Alexandros, George Frederick Vaughan, Sarah J. Denny, et al. "Comparison of NICE and ESC proposed strategies on new onset chest pain and the contemporary clinical utility of pretest probability risk score." Open Heart 7, no. 1 (2020): e001081. http://dx.doi.org/10.1136/openhrt-2019-001081.

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AimsPatients with de novo chest pain are usually investigated non-invasively. The new UK-National Institute for Health and Care Excellence (NICE) guidelines recommend CT coronary angiography (CTCA) for all patients, while European Society of Cardiology (ESC) recommends functional tests. We sought to compare the clinical utility and perform a cost analysis of these recommendations in two UK centres with different primary investigative strategies.Methods—resultsWe compared two groups of patients, group A (n=667) and group B (n=654), with new onset chest pain in two neighbouring National Health S

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Walkden, A., A. Clark, R. Dart, et al. "OC-013 Clinical utility of faecal calprotectin in diagnosing inflammatory bowel disease during first presentation to the gastroenterology clinic: a novel investigative algorithm: Abstract OC-013." Gut 59, Suppl 1 (2010): A6.1—A6. http://dx.doi.org/10.1136/gut.2009.208934m.

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Ghosh, Sudip K., John E. Pandolfino, Qing Zhang, Andrew Jarosz, Nimeesh Shah, and Peter J. Kahrilas. "Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers." American Journal of Physiology-Gastrointestinal and Liver Physiology 290, no. 5 (2006): G988—G997. http://dx.doi.org/10.1152/ajpgi.00510.2005.

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The vastly enhanced spatial resolution of high-resolution manometry (HRM) makes it possible to simultaneous monitor contractile activity over the entire length of the esophagus. The aim of this investigation was to define the essential features of esophageal peristalsis in novel HRM paradigms and establish their normative values. Ten 5-ml water swallows were recorded in each of 75 asymptomatic controls with a solid-state manometric assembly incorporating 36 circumferential sensors spaced at 1-cm intervals positioned to record from the hypopharynx to the stomach. The data set was then subjected

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McLachlan, Rowan H., Kerri L. Dobson, Emily R. Schmeltzer, Rebecca Vega Thurber, and Andréa G. Grottoli. "A review of coral bleaching specimen collection, preservation, and laboratory processing methods." PeerJ 9 (July 8, 2021): e11763. http://dx.doi.org/10.7717/peerj.11763.

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Under current climate warming predictions, the future of coral reefs is dire. With projected coral reef decline, it is likely that coral specimens for bleaching research will increasingly become a more limited resource in the future. By adopting a holistic approach through increased collaborations, coral bleaching scientists can maximize a specimen’s investigative yield, thus reducing the need to remove more coral material from the reef. Yet to expand a specimen’s utility for additional analytic methods, information on how corals are collected is essential as many methods are variably sensitiv

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Hacker, Philipp, and Chris Thomale. "Crypto-Securities Regulation: ICOs, Token Sales and Cryptocurrencies under EU Financial Law." European Company and Financial Law Review 15, no. 4 (2018): 645–96. http://dx.doi.org/10.1515/ecfr-2018-0021.

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Cryptocurrencies, such as bitcoin and ethereum, have not only risen to public attention as novel means of payments, but also as facilitators of initial coin offerings (ICOs, also called token sales). In these entirely online-mediated offerings, entrepreneurs sell tokens registered on a blockchain in exchange for cryptocoins. Buyers receive tokens that can be understood as cryptographically-secured coupons which embody a bundle of rights and obligations. In July 2017, the SEC released an investigative report that highlighted that such tokens can be subject to the full scope of US securities reg

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Naven, RT, and S. Louise-May. "Computational toxicology." Human & Experimental Toxicology 34, no. 12 (2015): 1304–9. http://dx.doi.org/10.1177/0960327115605440.

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Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify gaps in our understanding of mechanistic and chemical toxicology. Using recently published computational regression analyses of in vitro and in vivo toxicology data, it will be demonstrated that significant gaps remain in early safety screening paradigms. More strategic analyses

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Odongo, George, Richard Musabe, and Damien Hanyurwimfura. "A Multinomial DGA Classifier for Incipient Fault Detection in Oil-Impregnated Power Transformers." Algorithms 14, no. 4 (2021): 128. http://dx.doi.org/10.3390/a14040128.

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This study investigates the use of machine-learning approaches to interpret Dissolved Gas Analysis (DGA) data to find incipient faults early in oil-impregnated transformers. Transformers are critical pieces of equipment in transmitting and distributing electrical energy. The failure of a single unit disturbs a huge number of consumers and suppresses economic activities in the vicinity. Because of this, it is important that power utility companies accord high priority to condition monitoring of critical assets. The analysis of dissolved gases is a technique popularly used for monitoring the con

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Wells, Peter N. T., and Hai-Dong Liang. "Medical ultrasound: imaging of soft tissue strain and elasticity." Journal of The Royal Society Interface 8, no. 64 (2011): 1521–49. http://dx.doi.org/10.1098/rsif.2011.0054.

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After X-radiography, ultrasound is now the most common of all the medical imaging technologies. For millennia, manual palpation has been used to assist in diagnosis, but it is subjective and restricted to larger and more superficial structures. Following an introduction to the subject of elasticity, the elasticity of biological soft tissues is discussed and published data are presented. The basic physical principles of pulse-echo and Doppler ultrasonic techniques are explained. The history of ultrasonic imaging of soft tissue strain and elasticity is summarized, together with a brief critique

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Dalton, Sarah Grace Hudspeth, and Jessica D. Richardson. "A Large-Scale Comparison of Main Concept Production Between Persons With Aphasia and Persons Without Brain Injury." American Journal of Speech-Language Pathology 28, no. 1S (2019): 293–320. http://dx.doi.org/10.1044/2018_ajslp-17-0166.

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PurposeThe purposes of this study are to provide clinicians and researchers with introductory psychometric data for the main concept analysis (MCA), a measure of discourse informativeness, and specifically, to provide descriptive and comparative statistical information about the performance of a large sample of persons not brain injured (PNBIs) and persons with aphasia (PWAs) on AphasiaBank discourse tasks.MethodTranscripts of 5 semi-spontaneous discourse tasks were retrieved from the AphasiaBank database and scored according to detailed checklists and scoring procedures. Transcripts from 145

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Forny, Patrick, Emma Footitt, James E. Davison, et al. "Diagnosing Mitochondrial Disorders Remains Challenging in the Omics Era." Neurology Genetics 7, no. 3 (2021): e597. http://dx.doi.org/10.1212/nxg.0000000000000597.

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ObjectiveWe hypothesized that novel investigative pathways are needed to decrease diagnostic odysseys in pediatric mitochondrial disease and sought to determine the utility of clinical exome sequencing in a large cohort with suspected mitochondrial disease and to explore whether any of the traditional indicators of mitochondrial disease predict a confirmed genetic diagnosis.MethodsWe investigated a cohort of 85 pediatric patients using clinical exome sequencing and compared the results with the outcome of traditional diagnostic tests, including biochemical testing of routine parameters (lactat

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