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Journal articles on the topic 'Iodo-compounds'

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Published: 5 June 2025

Last updated: 24 June 2025

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1

Abdel Hamid, S., H. El-Obeid, K. Al-Rashood, A. Khalil, and H. El-Subbagh. "Substituted Quinazolines, 1. Synthesis and Antitumor Activity of Certain Substituted 2-Mercapto-4(3H)-quinazolinone Analogs." Scientia Pharmaceutica 69, no. 4 (2001): 351–66. http://dx.doi.org/10.3797/scipharm.aut-01-205.

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A new series of 4(3H)-quinazolinone analogs bearing 6-iodo and 2-thioether functions were synthesized and screened for their in vitro antitumor activity. Eight compounds were identified as active anticancer agents. 2-Mercapto-3-benzyl-4-thioxo-6-iodo-3H-quinazolin (2) and 2-(2,4-dinitrophenyl)-3-benzyl-6-iodo-4-(3H)-quinazolinone(9) proved to be the most active compounds in this study. They showed MG-MID GI50, TGI, LC50 values of 3.9, 25.2, 82.3 and 2.7, 12.3, 38.7 μM, respectively. The detailed synthesis and biological screening data are reported.

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2

Kumar, Rajesh, Nitya Sharma, and Om Prakash. "Hypervalent Iodine Reagents in the Synthesis of Flavonoids and Related Compounds." Current Organic Chemistry 24, no. 18 (2020): 2031–47. http://dx.doi.org/10.2174/1385272824999200420074551.

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Hypervalent iodine compounds have proved to be very useful reagents to bring about various oxidative transformations including (i) α-functionalization of carbonyl compounds, (ii) oxidation of phenols, and (iii) oxidative rearrangement of ketones and α,β- unsaturated ketones. These reactions find interesting applications in the development of newer and convenient approaches for the synthesis of flavonoids. This review focuses on the use of most common three hypervalent compounds, namely iodobenzene diacetate, [hydroxy(tosyloxy)iodo]benzene, and [bis-trifluoroacetoxy(iodo)]benzene in the synthesis of cis/trans-3-hydroxyflavanones, 3-hydroxyflavones (flavonols), flavones, isoflavones and related compounds.

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3

Chamsi, Ousama, Eric Pinelli, Bruno Faucon, et al. "Effects of herbicide mixtures on freshwater microalgae with the potential effect of a safener." Annales de Limnologie - International Journal of Limnology 55 (2019): 3. http://dx.doi.org/10.1051/limn/2019002.

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Freshwater microalgae are primary producers and cosmopolitan species subjected to the effects of herbicides. In this work, the in vitro algal growth inhibitory effects of 11 agrochemicals (9 herbicides, 1 metabolite, and 1 safener) were quantified. Chemical compounds were applied singly and in specific mixtures. Three species were used in axenic condition: the green alga Desmodesmus subspicatus (Chodat), the diatoms Nitzschia palea (Kützing) W. Smith and Navicula pelliculosa (Kützing) Hilse. When exposed to single compounds, N. palea and N. pelliculosa were only sensitive to atrazine/desethylatrazine and the safener benoxacor (BE), respectively. D. subspicatus was equally sensitive to four herbicides including atrazine and its metabolite and significantly more sensitive to iodosulfuron-methyl-sodium (IODO). The mixture of these five compounds induced a significantly higher growth inhibition of about 1.5-fold than IODO alone, which could be attributed to the four other herbicides. The mixture of all compounds was twofold less toxic than IODO on D. subspicatus. A halogen atom is present in IODO as in the herbicides to which the safener BE − known to induce glutathione-S-transferases − is associated in agrochemical preparations. We then showed that IODO was less toxic when combined with non-toxic concentrations of BE. These results indicated that the toxicity of the most active herbicide studied was decreased by a non-herbicide compound present in agrochemical formulations of other herbicides. These results suggest the importance to take into account the chemistry and the mechanisms of action for each compound in a risk assessment approach of a complex mixture.

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4

Wu, Jinsheng, Xiaolong Li, Mingyu Yang, Yujie Gao, Qianru Lv, and Baohua Chen. "Convenient synthesis of ferrocene amines via Cu-catalyzed coupling reaction." Canadian Journal of Chemistry 86, no. 9 (2008): 871–74. http://dx.doi.org/10.1139/v08-096.

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An efficient copper-catalyzed Ullmann-type cross-coupling reaction without ligand of iodo-ferrocene with amines has been reported. In this process, a range of ferrocenyl amine compounds have been prepared in moderate to good yields.Key words: amines, iodo-ferrocene, cross-coupling, copper, Ullmann coupling.

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5

S, G. ABDEL-HAMIDE. "Synthesis of some New Heterocyclic Systems bearing 2-Phenyl-6-iodo-4(3H)-quinazolinon-3-yl Moiety as Antibacterial Agents." Journal of Indian Chemical Society Vol. 74, Aug 1997 (1997): 613–18. https://doi.org/10.5281/zenodo.5891302.

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Pharmaceutical Chemistry Department, Al-Azhar University, Cairo, Nasr City, Egypt <em>Manuscript received 6 March 1995, revised 18 March 1996, accepted 24 July 1996</em> A number of heterobicyclic systems bearing 2-phenyl-6-iodo-4(3<em>H</em>)-quinazolinon-3-yl moiety have been synthesised by interaction of 3- amino-2-phenyl-6-iodo-4(3<em>H</em>)-quinazolinone with bifunctional compounds followed by cyclisation in different media. Some of the compounds possess high activity aganist bacteria.

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6

Agafonova, Anastasiya V., Ilia A. Smetanin, Nikolai V. Rostovskii, Alexander F. Khlebnikov, and Mikhail S. Novikov. "Easy Access to 2-Fluoro- and 2-Iodo-2H-azirines via the Halex Reaction." Synthesis 51, no. 24 (2019): 4582–89. http://dx.doi.org/10.1055/s-0039-1690200.

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A simple gram-scale method for the preparation of esters and dialkylamides of 2-(fluoro/iodo)-2H-azirine-2-carboxylic acids via the halogen exchange (Halex) reaction of 2-bromo-substituted analogues is reported. The method operates with inexpensive and safe reagents, Bu4NF and potassium iodide, providing high product yields. Alternatively, 2-fluoro-2H-azirine-2-carboxylates can be prepared from 2-iodo- and 2-chloro-analogues. The latter compounds can be obtained in practically quantitative yield by treating the 2-iodo- and 2-bromo-2H-azirine-2-carboxylic esters with Bu4NCl.

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7

Bacsa, Ildikó, Rebeka Jójárt, János Wölfling та ін. "Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors". Beilstein Journal of Organic Chemistry 13 (30 червня 2017): 1303–9. http://dx.doi.org/10.3762/bjoc.13.126.

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Novel 13α-estrone derivatives were synthesized by Sonogashira coupling. Transformations of 2- or 4-iodo regioisomers of 13α-estrone and its 3-methyl ether were carried out under different conditions in a microwave reactor. The 2-iodo isomers were reacted with para-substituted phenylacetylenes using Pd(PPh3)4 as catalyst and CuI as a cocatalyst. Coupling reactions of 4-iodo derivatives could be achieved by changing the catalyst to Pd(PPh3)2Cl2. The product phenethynyl derivatives were partially or fully saturated. Compounds bearing a phenolic OH group furnished benzofurans under the conditions used for the partial saturation. The inhibitory effects of the compounds on human placental 17β-hydroxysteroid dehydrogenase type 1 isozyme (17β-HSD1) were investigated by an in vitro radiosubstrate incubation method. Certain 3-hydroxy-2-phenethynyl or -phenethyl derivatives proved to be potent 17β-HSD1 inhibitors, displaying submicromolar IC50 values.

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8

Rochon, F. D., and P. C. Kong. "Iodo-bridged complexes of platinum(II) and synthesis of cis mixed-amine platinum(II) compounds." Canadian Journal of Chemistry 64, no. 9 (1986): 1894–96. http://dx.doi.org/10.1139/v86-312.

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Iodo-bridged platinum(II) dimers, [Pt(L)I2]2 with ligands (L) containing nitrogen as the donor atom, have been synthesized from the reactions of cis-[Pt(L)2I2] with perchloric acid. The dimers can be cleaved in aqueous media by a second nitrogen ligand to produce isometrically pure cis-[Pt(L)(L′)I2].These compounds can finally be converted to the chloro or carboxylato compounds by precipitating the iodo ligands with a silver salt and adding KCl or a carboxylate salt. Several compounds of the types cis-[Pt(L)(L′)Cl2] and cis-[Pt(L)(L′)(dicarboxylate)] were thus prepared. A few dimers of the type [(L)(L′)Pt(tetra-carboxylate)Pt(L)(L′)] were also synthesized.

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9

Glidewell, Christopher, John N. Low, Janet M. S. Skakle, Solange M. S. V. Wardell та James L. Wardell. "Isomeric iodo-N-(nitrobenzyl)anilines: interplay of hard and soft hydrogen bonds, iodo...nitro interactions and aromatic π...π stacking interactions". Acta Crystallographica Section B Structural Science 60, № 4 (2004): 472–80. http://dx.doi.org/10.1107/s0108768104012017.

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Molecules of 2-iodo-N-(4-nitrobenzyl)aniline, 4-O2NC6H4CH2NHC6H4I-2′ (1) are linked into chains by C—H...O hydrogen bonds. In the isomeric compound 3-iodo-N-(4-nitrobenzyl)aniline (2) a combination of N—H...O and C—H...O hydrogen bonds and iodo...nitro and aromatic π...π stacking interactions links the molecules into a three-dimensional framework structure. The two-dimensional supramolecular structure of 4-iodo-N-(4-nitrobenzyl)aniline (6) is built from a combination of C—H...O and N—H...π(arene) hydrogen bonds and aromatic π...π stacking interactions. 2-Iodo-N-(2-nitrobenzyl)aniline (7) crystallizes with two molecules in the asymmetric unit and these molecules are linked into ladders by a combination of N—H...O and C—H...O hydrogen bonds and iodo...nitro and aromatic π...π stacking interactions. Comparisons are made between the supramolecular structures of these compounds and those of other isomers, in terms both of the types of direction-specific intermolecular interactions exhibited and the dimensionality of the resulting supramolecular structures.

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10

Agbo, Gildenhuys та Mphahlele. "Inhibitory Effects of Novel 7-Substituted 6-iodo-3-O-Flavonol Glycosides against Cholinesterases and β-secretase Activities, and Evaluation for Potential Antioxidant Properties". Molecules 24, № 19 (2019): 3500. http://dx.doi.org/10.3390/molecules24193500.

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A series of 7-halogeno- (X = F, Cl, Br) and 7-methoxy-substituted acetylated 6-iodo-3-O-flavonol glycosides were prepared, and evaluated for inhibitory effect in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. 7-Bromo-2-(4-chlorophenyl)-6-iodo-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2k) and 7-bromo-6-iodo-2-(4-methoxyphenyl)-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2l) exhibited significant inhibitory effect against AChE activity when compared to the activity of the reference standard, donepezil. Compound 2k was found to be selective against AChE and to exhibit reduced inhibitory effect against BChE activity. 6-Iodo-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one-3-O-2,3,4,6-O-tetraacetyl-β-d-glucopyranoside (2p) was found to exhibit increased activity against BChE, more so than the activity of donepezil. The most active compounds were also evaluated for inhibitory effect against β-secretase activity and for potential radical scavenging activities. The experimental data were complemented with molecular docking (in silico) studies of the most active compounds into the active sites of these enzymes.

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11

Garden, Simon J., Silvia P. Fontes, James L. Wardell, Janet M. S. Skakle, John N. Low та Christopher Glidewell. "Interplay of hydrogen bonds, iodo...nitro interactions and aromatic π...π stacking interactions in iodo-nitroanilines". Acta Crystallographica Section B Structural Science 58, № 4 (2002): 701–9. http://dx.doi.org/10.1107/s0108768102007978.

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Molecules of 2-iodo-5-nitroaniline (I) are linked by N—H...O hydrogen bonds into centrosymmetric dimers and by asymmetric three-centre iodo...nitro interactions into chains, so forming chains of fused centrosymmetric rings: these chains are linked by aromatic π...π stacking interactions to form a three-dimensional structure. In the isomeric 4-iodo-2-nitroaniline (II), each of the two independent molecules forms hydrogen-bonded chains that are linked by two-centre iodo...nitro interactions into sheets of two types, each containing only a single type of molecule: π...π stacking interactions are absent. In 2,4-diiodo-3-nitroaniline (III), where the nitro group is almost orthogonal to the aryl ring, a combination of N—H...O hydrogen bonds and two distinct two-centre iodo...nitro interactions links the molecules into a three-dimensional framework that is reinforced by aromatic π...π stacking interactions. Bond lengths and conformations are discussed and comparisons are drawn with related compounds.

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12

Kulkarni, S., and MR Grimmett. "Nucleophilic Displacements of Imidazoles. II. Displacements of Halogen by S-Nucleophiles and Displacements of Mesyl Groups Activated by Nitro; Oxidation of Imidazolethiols." Australian Journal of Chemistry 40, no. 8 (1987): 1415. http://dx.doi.org/10.1071/ch9871415.

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In basic medium arylthiols displace bromo and iodo groups activated by nitro substituents in 5(4)-halo-4(5)- nitroimidazoles . The bromo compounds are slightly more reactive than the iodo analogues. Substituents at C5 are more readily displaced than those at C4. Methylsulfonyl groups, similarly activated by an adjacent nitro substituent, are displaced by a variety of nucleophiles. The imidazolethiol products are readily oxidized to the sulfones.

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13

Tanaka, Hiromichi, Kazuhiro Haraguchi, Yachiyo Koizumi, Mariko Fukui, and Tadashi Miyasaka. "Synthesis of 6-alkynylated uridines." Canadian Journal of Chemistry 64, no. 8 (1986): 1560–63. http://dx.doi.org/10.1139/v86-257.

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6-Alkynylated uridines, a hitherto unknown class of compounds, were synthesized by a coupling reaction of terminal alkynes with 6-iodo-2′,3′-O-isopropylidene-5′-O-methoxymethyluridine in the presence of bis(triphenylphosphine)palladium(II) chloride and copper(I) iodide. 6-Ethynyl-2′-deoxyuridine was also prepared by using 6-iodo-3′,5′-O-(tetraisopropyldisiloxan-1,3-diyl)-2′-deoxyuridine as a starting material.

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14

Hauenschild, Till, and Dariush Hinderberger. "A New Rapid and Specific Iodination Reagent for Phenolic Compounds." Organics 4, no. 2 (2023): 137–45. http://dx.doi.org/10.3390/org4020011.

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A new rapid iodination reagent, N1,N3,N5-tris[(2,4,6-trimethylpyridine)iodo(I)]-2,4,6-triphenyl-s-triazine trihexafluorophosphate, was synthesized in a modification of the established synthesis of 2,4,6-triiodo-3,5-dimethylphenol in the presence of bis(2,4,6-trimethylpyridine)iodo(I) hexafluorophosphate and used for the precise post-modification of mono- and trisubstituted phenyl compounds. We performed triple iodinations with our new phenyl-based compounds as a proof of principle of selected types of phenols, ß-sympatholytic agents and their spin-labeled derivatives, which can be employed in electron paramagnetic resonance (EPR) spectroscopy. The new rapid iodination reagent can be employed with high reactivity and regioselectivity.

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15

Dişli, Ali, Murat Gümüş, Kübra Önal, Nurşen Sarı, and Fatma Arslan. "New multifunctional agents and their inhibitory effects on the acetyl cholinesterase enzyme." Macedonian Journal of Chemistry and Chemical Engineering 37, no. 1 (2018): 21. http://dx.doi.org/10.20450/mjcce.2018.1334.

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A novel series of 2-((-1-substituted phenyl-1H-tetrazol-5-yl)thio)-2,3-dihydro-1H-inden-1-one compounds were designed, synthesized, and evaluated as multi-potent anti-Alzheimer drug candidates. First, treatment of various organic isothiocyanates with sodium azide in the presence of pyridine gave corresponding 1-substituted phenyl-1H-tetrazol-5-thiol compounds. Then, novel 2-((-1-substituted phenyl-1H-tetrazol-5-yl)thio)-2,3-dihydro-1H-inden-1-one compounds were synthesized by treatment of 2,3-dihydro-1H-inden-1-one with the 1-substituted phenyl-1H-tetrazol-5-thiol in the presence of I2. The synthesized compounds were characterized by spectroscopic methods. The inhibitory effects of the synthesized compounds on the acetyl cholinesterase enzyme (AChE) were then tested. An o-iodo substituent displayed higher activity compared to the other analogs. The o-iodo substituent showed a mixed-type of the AChE with an IC50 value of 1.75 μM. For the studied compunds all IC50 values for AChE were in the micromolar range.

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16

Bernhardt, Paul V., Raymond M. Carman, and Tri T. Le. "The Stereo Structures of Some Mycophenolic Acid Derivatives." Australian Journal of Chemistry 60, no. 5 (2007): 354. http://dx.doi.org/10.1071/ch06481.

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17

Kayser, Bernd, and Wolfgang Beck. "Metal Complexes of Biologically Important Ligands, CLVI [1]. Metal Complexes of 4-Iodo-L-phenylalanine. Oxidative Addition of 4-Iodo-L-phenylalanine Ester to Palladium(0)." Zeitschrift für Naturforschung B 59, no. 11-12 (2004): 1423–28. http://dx.doi.org/10.1515/znb-2004-11-1209.

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4-Iodo-L-phenylalanine gives with the chloro bridged compounds [(Et3P)PtCl2]2, [(Et3P)PdCl2]2 and [Cp*IrCl2]2 the N,O-chelate complexes (L)(Cl)M[NH2-C(H)(CH2C6H4I)CO2] (M = Pt, Pd, Ir; L = PEt3, Cp* ) (1 - 3). Oxidative addition of N-protected 4-iodo-L-phenylalanine methylester to Pd(dba)2 in the presence of 2,2’-bipyridyl or of triphenylphosphine affords the p-phenyl metallated amino acids (bipy)(I)Pd[C6H4CH2C(H)(NHR)CO2Me] (4,5) and (PPh3)2 (I)Pd[C6H4CH2C(H)(NHR) CO2Me] (6,7). Oxidative addition of the coordinated 4-iodo-Lphenylalaninate in (Et3P)(Cl)M[NH2C(H)(CH2C6H4I)CO2] to Pd(dba)2 was also observed.

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18

Ren, Hang, Haoyun An, and Jingchao Tao. "Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives." Molecules 24, no. 5 (2019): 983. http://dx.doi.org/10.3390/molecules24050983.

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Glycosylation of 6-amino-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine and its iodo- and bromo- analogues with the protected ribofuranose and 2′-deoxyribofuranose under different conditions resulted in the synthesis of N9- and N8-glycosylated purine nucleosides. Five key intermediate nucleosides, having 6-methoxy, 7-iodo, and 2-bromo groups, were further derivatized to 23 final 8-aza-7-deazapurine nucleoside derivatives. The structures of N9- and N8-glycosylated products were assigned based on UV and NMR spectra. HMBC analysis of 2D NMR spectra and X-ray crystallographic studies of the representative compounds unambiguously verified the connection of ribose ring to N9- or N8-position of the purine ring. The anticancer activity of these new compounds was evaluated.

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19

Dyląg, Agnieszka, Sylwester Smoleń, Anna Wisła-Świder, et al. "Evaluation of the chemical composition and nutritional value of lettuce (Lactuca sativa L.) biofortified in hydroponics with iodine in the form of iodoquinolines." Frontiers in Plant Science 14 (November 23, 2023): 1288773. https://doi.org/10.3389/fpls.2023.1288773.

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Iodine deficiency in the diet creates the need to search for innovative, more sustainable and more effective strategies for enriching food with this microelement. The adopted research hypothesis assumed that the use of organic forms of iodine for supplementation of lettuce (Lactuca sativa L.), compared to mineral iodine, has a more favorable effect not only on the concentration of iodine, but also on the yield and the content of other chemical components determining its nutritional and health-promoting value. Lettuce was planted in a nutrient film technique (NFT) hydroponic study in a greenhouse. The following application of iodine compounds (all in 5 μM molar mass equivalents) were tested in the studies: control (without of iodine application); potassium iodate (positive iodine control), 8-hydroxy-7-iodo-5-quinolinesulfonic acid, 5-chloro-7-iodo-8-quinolinol, 5,7-diiodo-8-quinolinoland 4-hydroxy-8-iodo-3-quinolinecarboxylic acid. In this work, it was shown for the first time that iodoquinolines can be 1) a source of iodine for plants; 2) they have a biostimulating effect on their yielding and 3) they increase the resistance of crops to stress (due to a significant increase in the level of polyphenolic compounds). Lettuce with the addition of 8-hydroxy-7-iodo-5-quinolinesulfonic acid was characterized by the highest content of iodine, which was 221.7 times higher than in control plants. The weight gain of the whole plant was particularly visible in the case of lettuce enriched with 5-chloro-7-iodo-8-quinolinol and amounted to 26.48% compared to the control. Lettuce biofortified with iodine in the form of iodoquinolines can successfully become part of a sustainable diet based on plant products, which has a low impact on the environment and contributes to the long-term good health of an individual or community. Reducing iodine deficiency through the use of organoiodine compounds can help achieve the sustainability goal of eliminating hidden hunger, improving nutritional status and promoting sustainable agriculture.

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20

Leonhardt, Thomas, and Hans Peter Latscha. "Photochemische Synthese neuer zinnorganischer Verbindungen mit „aktiven“ Gruppen am Zinnatom (I) / Photochemical Synthesis of New Tinorganic Compounds with Active Substituents on Tin." Zeitschrift für Naturforschung B 52, no. 1 (1997): 25–29. http://dx.doi.org/10.1515/znb-1997-0105.

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By photochemically induced oxidative addition reactions the synthesis of some new tinorganic compounds was achieved. The reaction of dichloro-and diiodotin with 1,2-diiodobenzene (1) induced by ultraviolet radiation led to bis-(1-iodophenyl)diiodotin (2), bis-(1-iodophenyl)dichlorotin (3), 1 -iodo-2-(trichlorotin)benzene (4) and 1-iodo-2-(triiodotin)benzene (5). Iodosubstitution at the tin atom was also observed when dichlorotin was used as the starting compound. Analogous experiments with 1,2-dibromobenzene (6) and 1,2-dichloro-(7) gave no products

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21

Medina, Inmaculada C. Rodriguez, and James R. Hanson. "The Oxidative Bromination and Iodination of Dimethylacetanilides." Journal of Chemical Research 2003, no. 7 (2003): 428–29. http://dx.doi.org/10.3184/030823403103174399.

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The oxidative bromination and iodination of the six dimethylacetanilides have been examined; whereas bromination of 2,4-dimethyl- and 2,6-dimethylacetanilides using potassium bromide, sodium tungstate and peracetic acid gave predominantly the 6- and 4-bromo compounds respectively, the 5- and 3-iodo compounds were obtained using hydrogen iodide and peracetic acid.

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22

Krylov, Igor B., Stanislav A. Paveliev, Mikhail A. Syroeshkin, et al. "Hypervalent iodine compounds for anti-Markovnikov-type iodo-oxyimidation of vinylarenes." Beilstein Journal of Organic Chemistry 14 (August 16, 2018): 2146–55. http://dx.doi.org/10.3762/bjoc.14.188.

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The iodo-oxyimidation of styrenes with the N-hydroxyimide/I2/hypervalent iodine oxidant system was proposed. Among the examined hypervalent iodine oxidants (PIDA, PIFA, IBX, DMP) PhI(OAc)2 proved to be the most effective; yields of iodo-oxyimides are 34–91%. A plausible reaction pathway includes the addition of an imide-N-oxyl radical to the double C=C bond and trapping of the resultant benzylic radical by iodine. It was shown that the iodine atom in the prepared iodo-oxyimides can be substituted by various nucleophiles.

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23

Balova, Irina A., Natalia A. Danilkina, and Anastasia I. Govdi. "5-Iodo-1H-1,2,3-triazoles as Versatile Building Blocks." Synthesis 52, no. 13 (2020): 1874–96. http://dx.doi.org/10.1055/s-0039-1690858.

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Copper-catalyzed azide–alkyne cycloaddition is a useful tool for the synthesis of both 1,2,3-triazoles and 5-iodo-1H-1,2,3-triazoles starting from either terminal alkynes or iodoalkynes. 5-Iodotriazoles have been recognized as very useful building blocks for the synthesis of diverse 1,4,5-trisubstituted 1,2,3-triazoles. Synthetic application of 5-iodo-1,2,3-triazoles through the creation of a new C–C, C–heteroatom, or C–D(T) bond along with the application areas of both iodotriazoles and products of their modification including radiolabeled compounds are discussed.1 Introduction2 Synthetic Approaches to 5-Iodo-1H-1,2,3-triazoles3 5-Iodotriazoles in C–C Bond Formation3.1 Intermolecular C–C Cross-Coupling3.2 Intramolecular Cross-Coupling: Direct Arylation and C–I/C–I Homocoupling3.3 Other Transformations4 5-Iodotriazoles in Radiolabeling, Halogen Exchange, and Heterocoupling Reactions5 Summary

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24

Krzemińska, Joanna, Joanna Kapusta-Duch, Sylwester Smoleń, et al. "Iodine enriched kale (Brassica oleracea var. sabellica L.)—The influence of heat treatments on its iodine content, basic composition and antioxidative properties." PLOS ONE 19, no. 6 (2024): e0304005. http://dx.doi.org/10.1371/journal.pone.0304005.

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Iodine deficiency in the diet globally continues to be a cause of many diseases and disabilities. Kale is a vegetable that has health-promoting potential because of many nutrients and bioactive compounds (ascorbic acid, carotenoids, glucosinolates and phenolic compounds). Brassica vegetables, including kale, have been strongly recommended as dietary adjuvants for improving health. The nutrient and health-promoting compounds in kale are significantly affected by thermal treatments. Changes in phytochemicals upon such activities may result from two contrary phenomena: breakdown of nutrients and bioactive compounds and a matrix softening effect, which increases the extractability of phytochemicals, which may be especially significant in the case of iodine-fortified kale. This study investigated changes of basic composition, iodine, vitamin C, total carotenoids and polyphenols contents as well as antioxidant activity caused by steaming, blanching and boiling processes in the levels of two cultivars of kale (green and red) non-biofortified and biofortified via the application to nutrient solutions in hydroponic of two iodoquinolines [8-hydroxy-7-iodo-5-quinolinesulfonic acid (8-OH-7-I-5QSA) and 5-chloro-7-iodo-8-quinoline (5-Cl-7-I-8-Q)] and KIO3. Thermal processes generally significantly reduced the content of the components in question and the antioxidant activity of kale, regardless of cultivar and enrichment. It was observed that the red cultivar of kale had a greater ability to accumulate and reduce iodine losses during the culinary processes. 8-hydroxy-7-iodo-5-quinolinesulfonic acid showed a protective effect against the treatments used, compared to other enrichments, thus contributing to the preservation of high iodine content.

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Raval, Jignesh Priyakant, Akhaja T N, Myangar K N, and D. R. Naik. "Synthesis of Novel Azetidinyl-3-(isonicotinamide-yl)-6-iodoquinazolin- 4-ones as Antimicrobial and Antitubercular Agents." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 2 (2012): 1735–44. http://dx.doi.org/10.37285/ijpsn.2012.5.2.9.

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A novel new series of 2-[(4'-oxo-3'-chloro-2'-phenylazetidin-1'-yl)-aminomethyl]-3-[N-isonicotinamide-yl]-6-iodo-quinazolin-4-ones were synthesized using the reaction of chloroacetylchloride and appropriate Schiff base. The synthesized compounds were characterized on the basis of their elemental and spectral analysis (IR, 1H-NMR, 13C-NMR and mass spectrometry). All newly synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv. They were also tested in vitro for antibacterial activity against selected human pathogens such as E. coli, P. aeruginosa, K. pneumoniae, S. typhi, S. aureus, S. pyogenus, B. subtilis and antifungal activity against C. albicans, A. niger, A. clavatus strains. The selected 6-iodo-quinazolinonones showed promising biological activity and could be useful as antimicrobial agents. 

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26

Turhanen, Petri A., та Jouko J. Vepsäläinen. "Preparation of useful building blocks, α-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach". RSC Advances 6, № 19 (2016): 15937–40. http://dx.doi.org/10.1039/c5ra20813k.

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Novel method for preparation of α-iodo- and bromoalkanols directly from cyclic ethers has been developed. Prepared compounds are highly important building blocks in synthetic chemistry for the preparation of more complex molecules.

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27

Saporito, Dafne, Sergio A. Rodriguez, and Maria T. Baumgartner. "Visible Light-Promoted C–C Bond Formation from Hydroxyaryls in Water." Australian Journal of Chemistry 72, no. 12 (2019): 978. http://dx.doi.org/10.1071/ch19378.

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An eco-friendly and direct arylation of hydroxyaryls in water using photoinduced reactions with different substrates (1-bromo-2-naphthol, 1-iodo-2-naphthol, N-(2-iodophenyl)acetamide, 5-bromouracil, 2-iodo-N-methylbenzamide, and 2-iodobenzamide) was studied. For example, π-expanded coumarins, compounds with potential optical applications, were synthesized in very high yield, without the use of toxic reagents, in a one-pot reaction. In addition, we demonstrate that the irradiation source (halogen lamp) can be efficiently replaced by an LED without altering the reaction yield.

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28

Horta, Pedro, Marta S. C. Henriques, Elisa M. Brás, et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate." Pure and Applied Chemistry 89, no. 6 (2017): 765–80. http://dx.doi.org/10.1515/pac-2016-1119.

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AbstractRecent studies directed to the design of compounds targeting the bc1 protein complex of Plasmodium falciparum, the parasite responsible for most lethal cases of malaria, identified quinolones (4-oxo-quinolines) with low nanomolar inhibitory activity against both the enzyme and infected erythrocytes. The 4-oxo-quinoline 3-ester chemotype emerged as a possible source of potent bc1 inhibitors, prompting us to expand the library of available analogs for SAR studies and subsequent lead optimization. We now report the synthesis and structural characterization of unexpected ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate, a 4-aryloxy-quinoline 3-ester formed during attempted preparation of 6-methyl-7-iodo-4-oxo-quinoline-3-carboxylate (4-oxo-quinoline 3-ester). We propose that the 4-aryloxy-quinoline 3-ester derives from 6-methyl-7-iodo-4-hydroxy-quinoline-3-carboxylate (4-hydroxy-quinoline 3-ester), the enol form of 6-methyl-7-iodo-4-oxo-quinoline-3-carboxylate. Formation of the 4-aryloxy-quinoline 3-ester confirms the impact of quinolone/hydroxyquinoline tautomerism, both on the efficiency of synthetic routes to quinolones and on pharmacologic profiles. Tautomers exhibit different cLogP values and interact differently with the enzyme active site. A structural investigation of 6-methyl-7-iodo-4-oxo-quinoline-3-carboxylate and 6-methyl-7-iodo-4-hydroxy-quinoline-3-carboxylate, using matrix isolation coupled to FTIR spectroscopy and theoretical calculations, revealed that the lowest energy conformers of 6-methyl-7-iodo-4-hydroxy-quinoline-3-carboxylate, lower in energy than their most stable 4-oxo-quinoline tautomer by about 27 kJ mol−1, are solely present in the matrix, while the most stable 4-oxo-quinoline tautomer is solely present in the crystalline phase.

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29

Cooke, Manning P., and Ioannis N. Houpis. "Metal-halogen exchange-initiated cyclization of iodo carbonyl compounds." Tetrahedron Letters 26, no. 41 (1985): 4987–90. http://dx.doi.org/10.1016/s0040-4039(01)80833-9.

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30

Carr, Richard M., Karl M. Cable, Guy N. Wells, and Derek R. Sutherland. "A convenient method for cyanation of aromatic iodo compounds." Journal of Labelled Compounds and Radiopharmaceuticals 34, no. 9 (1994): 887–97. http://dx.doi.org/10.1002/jlcr.2580340910.

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31

Raner, KD, and AD Ward. "Heterocyclic Syntheses Through Electrophilic Ring Closure Reactions of ortho-Allylaniline Systems." Australian Journal of Chemistry 44, no. 12 (1991): 1749. http://dx.doi.org/10.1071/ch9911749.

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Amide derivatives of 2-allylanilines have been prepared by metallation of the amide derivatives of the corresponding 2-bromoanilines and subsequent reaction with an allylic halide. The electrophile -promoted cyclization of these compounds has been investigated. The free allylanilines readily undergo aminomercuration to form unstable mercury derivatives of tetrahydroquinolines but the corresponding amide derivatives do not cyclize. Instead, oxymercuration of the double bond occurs. The allylanilines react with iodine to yield 3-iodo-1,2,3,4-tetrahydroquinolines. The anion of 2,2,2-trifluoro-N-[4-hydroxymethyl-2-(3-methylbut-2-enyl)phenyl] acetamide reacts with iodine to give a 2,3-dihydroindole. These iodinated compounds can be further cyclized with base to form 7,7a-dihydro-1H-azirino[1,2-a] indoles. One of these aziridine systems was cleaved with hydrogen chloride to form a mixture of chlorinated tetrahydroquinoline and dihydroindole analogous to the iodo systems.

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32

Espinoza-Vázquez, Araceli, Francisco Javier Rodríguez-Gómez, Ivonne Karina Martínez-Cruz, et al. "Adsorption and corrosion inhibition behaviour of new theophylline–triazole-based derivatives for steel in acidic medium." Royal Society Open Science 6, no. 3 (2019): 181738. http://dx.doi.org/10.1098/rsos.181738.

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The design and synthesis of a series of theophylline derivatives containing 1,2,3-triazole moieties are presented. The corrosion inhibition activities of these new triazole–theophylline compounds were evaluated by studying the corrosion of API 5 L X52 steel in 1 M HCl medium. The results showed that an increase in the concentration of the theophylline–triazole derivatives also increases the charge transference resistance ( R ct ) value, enhancing inhibition efficiency and decreasing the corrosion process. The electrochemical impedance spectroscopy under static conditions studies revealed that the best inhibition efficiencies (approx. 90%) at 50 ppm are presented by the all-substituted compounds. According to the Langmuir isotherm, the compounds 4 and 5 analysed exhibit physisorption–chemisorption process, with exception of the hydrogen 3 , bromo 6 and iodo 7 substituted compounds, which exhibit chemisorption process. The corrosion when submerging a steel bar in 1 M HCl was studied using SEM-EDS. This experiment showed that the corrosion process decreases considerably in the presence of 50 ppm of the organic inhibitors. Finally, the theoretical study showed a correlation between E HOMO , hardness ( η ), electrophilicity (W), atomic charge and the inhibition efficiency in which the iodo 7 substituted compound presents the best inhibitor behaviour.

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33

Yoneda, Norihiko. "Advances in the preparation of organofluorine compounds involving iodine and/or iodo-compounds." Journal of Fluorine Chemistry 125, no. 1 (2004): 7–17. http://dx.doi.org/10.1016/s0022-1139(03)00159-3.

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34

Li, Chunbao, Wenjiao Yuan та Yali Liu. "A Rapid and Diastereoselective Synthesis of 2-Deoxy-2-iodo-α-glycosides and its Mechanism for Diastereoselectivity". Synlett 28, № 15 (2017): 1975–78. http://dx.doi.org/10.1055/s-0036-1588440.

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Reductive deiodination of 2-deoxy-2-iodo-glycoside is an efficient and practical approach for the synthesis of 2-deoxyglycosides, which are moieties of bioactive compounds. However, inseparable diastereoisomers are usually formed in the preparation of 2-deoxy-2-iodo-glycosides via glycosylation of glycals with alcohols using current methods. To overcome this problem, a rapid and diastereoselective transformation of glycals and alcohols into 2-deoxy-2-iodo-α-glycosides enabled by I2/PhI(OAc)2 has been developed. 14 glycals, derived from 13 monosaccharides and one disaccharide, diastereoselectively yielded α-glycosides. Only in two cases the diastereoselectivity of the glycosylation was poor. The yields of glycosylation range from 73% to 95%, and the reactions are finished in only five minutes. Investigations for better diastereoselectivity by comparing I2/Ph(OAc)2- with I2/Cu(OAc)2-mediated glycosylations using UV analysis have been conducted.

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35

Kira, T., H. Awano, S. Shuto, et al. "The FIAU Derivative (2′S)-2′-Deoxy-2′-C-Methyl-5-Iodouridine (SMIU) is a Novel, Less Cytotoxic and Potent anti-HSV and anti-VZV Agent." Antiviral Chemistry and Chemotherapy 7, no. 4 (1996): 209–12. http://dx.doi.org/10.1177/095632029600700406.

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In this study, the anti-herpetic activities of novel 2′-methyl nucleoside analogues which were substituted at the 5 position of the pyrimidine with a halogen were investigated. The 2′-fluoro-5-iodo-aracytosine (FIAC) congeners (2′S)-2′-deoxy-2′- C-methylcytidine which were substituted with Br or I at the 5 position (SMBC or SMIC); and 2′-fluoro-5-iodo-arauridine (FIAU) congeners (2′S)-2′-deoxy-2′-C-methyluridine which were substituted with Br or I at the 5 position (SMBU or SMIU), proved to have potent antiviral activities against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV) but not against herpes simplex virus type-2 (HSV-2). SMIU has a higher selective index against HSV-1 than FIAU, and both SMIC and SMIU showed higher inhibitory effects against VZV replication than aciclovir. The four effective compounds were not inhibitory to a thymidine kinase (TK)-negative HSV-1 strain, and this result indicates that phosphorylation of the compounds by HSV or VZV-TK is necessary for the activation of these compounds.

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36

Talybov, G. М. "Synthesis and intramolecular cyclization of propargyl ethers derived from 1-bromo(iodo)-3-organyloxy-2-propanol." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 1 (February 2025): 80–85. https://doi.org/10.32434/0321-4095-2025-158-1-80-85.

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The interaction of bromine (iodine)-releasing reagents, such as N-bromosuccinimide (NBS) or a mixture of iodine and clinoptilolite ((NaK)4CaAl6Si30O72), with an equimolar mixture of 3-organyloxy-1-propene and propynol results in the formation of propargyl ethers of 1-bromo(iodo)-3-organyloxy-2-propanol. The outcome of the catalytic hydration reaction of these ethers depends on the halogen atom present. Bromo derivatives are converted into the expected keto-bromo ethers, whereas iodo derivatives undergo simultaneous hydrolysis of the C–I bond and intermolecular ketalization, forming hydroxy derivatives of 1,4-dioxane. The hydration products of propargyl ethers derived from 1-bromo-3-organyloxy-2-propanol serve as key compounds for the synthesis of 2,2,5-trisubstituted 1,4-dioxanes through intermediate hydroxy diethers formed via reactions with organomagnesium reagents. The reactions and purity of the synthesized compounds were monitored using thin-layer chromatography. The yields of allyl ethers were higher than those of propargyl ethers. Some physicochemical properties of the synthesized compounds were measured, their composition and structure were confirmed by elemental analysis, and their identities were verified using IR and NMR spectroscopy.

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37

Osarumwense, Osarodion Peter. "Synthesis and antibacterial activity of 3-amino-6-iodo-2-methyl quinazolin 4-(3H)-one and 6-iodo-2-methyl-4H-benzo [D] [1, 3] oxazin-4-one." World Journal of Advanced Research and Reviews 2, no. 3 (2019): 014–20. https://doi.org/10.5281/zenodo.4309464.

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Quinazolines and its derivatives represent one of the most active classes of compounds, which possess wide range of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory, anticancer, and anti-hypertensive ,antifungal, anti-HIV, antioxidant, analgesic, anticonvulsant, antimalarial, antitumor, anti-tubercular activities. The objective of the present study was to synthesize these quinazolinone derivatives 6-iodo-2-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-amino-6-iodo-2—methyl-3H-quinazolin-4-one and evaluate them for their antibacterial activity. 6-lodo-4H-benzoxazin-4-one was synthesized by the reaction of 2-amino-5-Iodomethylbenzoat and acetic anhydride which reacted with nitrogen  nucleophile,  namely hydrazine hydrate to obtain 3-amino-6-iodo-2-methyl-3H-quinazolin-4-one. The structures of the compounds were confirmed with Infrared Spectra, Proton Nuclear Magnetic Resonance, Carbon thirteen Nuclear Magnetic Resonance, mass spectra and elemental analysis. These compounds were screen for their antibacterial activities against a number of microorganisms, <em>Escherichia coli</em>, <em>Klebsiella pneumonia</em>, Bacillius species, <em>Staphylococcus aurous</em>, <em>Pseudomonas aeruginosa</em> and <em>Candida albican</em>. The test investigated compounds exhibited significant antibacterial activity against the bacteria when compared with the control test sample. For the IR spectra, compound 1 were characterized by absence of υ NH<sub>2</sub>and presence of υ C-O stretch in 1159 cm<sup>-1</sup> region of the compound. Compound 2 was characterized by absence of υ C-O and presence of υNH<sub>2</sub> in 3284 cm<sup>-1</sup>and 3194 cm<sup>-1 </sup>region of the compound. The compounds synthesized exhibited promising antibacterial activities against <em>Staphylococcus aureus</em>, <em>Bacillus species</em> and <em>Pseudomonas aeruginosa,</em> stock cultures. The compounds have high activity against the microorganisms. Compound 2 has a higher activity against <em>Pseudomonas aeruginosa</em> compared to compound 1.

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38

Yadav, J. S., G. Kondaji, M. Shiva Ram Reddy та P. Srihari. "Facile synthesis of α-iodo carbonyl compounds and α-iodo dimethyl ketals using molecular iodine and trimethylorthoformate". Tetrahedron Letters 49, № 23 (2008): 3810–13. http://dx.doi.org/10.1016/j.tetlet.2008.03.151.

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39

Carvalho, Mário G. de, Virginia C. da Silva, Tânia M. S. da Silva, Celso A. Camara, and Raimundo Braz-Filho. "New iodine derivatives of flavonol and isoflavone." Anais da Academia Brasileira de Ciências 81, no. 1 (2009): 21–28. http://dx.doi.org/10.1590/s0001-37652009000100004.

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The reaction of the flavonol 3,7,3', 4'-tetra-O-methylquercetin (1) and of the isoflavone 7,4'-di-O-methylgenistein (2) with alkaline iodine in methanol afforded four new iodine derivatives: 8-iodo-5-hydroxy-3,7,3', 4'-tetramethoxy- flavone (1a) and 6-iodo-5-hydroxy-3,7,3', 4'-tetramethoxyflavone (1b) from 1; 2 afforded a mixture of two compounds, identified as a racemic mixture of (±)-trans-5-hydroxy-2,3,7,4'-tetramethoxy-8-iodo-isoflavanone (2a) and (±)-trans-5-hydroxy-2,3,7,4'-tetramethoxy-6,8-diiodo-isoflavanone (2b). The formation of these different products reveals a significant difference involving the chemical interaction between the reactive site of α, β-unsaturated ketones of flavonol and isoflavone under the tested reaction conditions (using I2/KOH/MeOH). Furthermore, the trans stereo selectivity is noteworthy in the nucleophylic addition of methanol at the isoflavone α, β-unsaturated system. The structures were identified on the basis of spectral data, mainly 1D and 2D NMR and mass spectra.

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40

Al-Matarneh, Cristina Maria, Alina Nicolescu, Ioana Cristina Marinaş, et al. "New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity." Molecules 29, no. 4 (2024): 772. http://dx.doi.org/10.3390/molecules29040772.

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6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as a catalyst under acidic conditions. Iodo-aniline, pyruvic acid and 22 phenyl-substituted aldehydes (we varied the type and number of radicals) or O-heterocycles, resulting in different electronic effects, were the starting components. This approach offers advantages such as rapid response times, cost-effective catalysts, high product yields and efficient purification procedures. A comprehensive investigation was conducted to examine the impact of aldehyde structure on the synthesis pathway. A library of compounds was obtained and characterized by FT-IR, MS, 1H NMR and 13C NMR spectroscopy and single-ray crystal diffractometry. Their antimicrobial activity against S. epidermidis, K. pneumonie and C. parapsilosis was tested in vitro. The effect of iodo-quinoline derivatives on microbial adhesion, the initial stage of microbial biofilm development, was also investigated. This study suggests that carboxy-quinoline derivatives bearing an iodine atom are interesting scaffolds for the development of novel antimicrobial agents.

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41

Zeidler, Joanna. "Modified Tricyclic Analogues of Acyclovir. A Direct Alkynylation in the Fused Ring." Collection of Czechoslovak Chemical Communications 69, no. 8 (2004): 1610–30. http://dx.doi.org/10.1135/cccc20041610.

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Two types of new 7-alkynylated tricyclic analogues (3,9-dihydro-5H-imidazo[1,2-a]purin-9-ones) of acyclovir differing by the presence of N-5 substituent, a temporary 2-(4-nitrophenyl)ethyl or a permanent 3-hydroxypropyl were obtained by a Sonogashira coupling. 7-Alk-1-ynyl-5-(3-acetoxypropyl) compounds (19a-19d, 21a-21c) were efficiently prepared from 7-iodo, 7-iodo-6-methyl precursors 12 and 11, respectively, and deprotected while the products with unsubstituted N-5 were unstable (e.g. 17). Iodide 12 was generally less reactive than 11 and underwent a preferable reduction (48%) to deiodinated 8 when coupled with ethynyltrimethylsilane.

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42

Hoefnagel, Anthonius J., та Bartholomeus M. Wepster. "Further studies an the extended Hammett equation comprising the hydrophobic constant: Reactivity data for benzoic acids, arylacetic acids, β-arylpropionic acids, trans- and cis-cinnamic acids, methyl benzoates; dissociation constants, DDM reaction and alkaline hydrolysis in various water-organic solvent mixtures". Collection of Czechoslovak Chemical Communications 55, № 1 (1990): 119–35. http://dx.doi.org/10.1135/cccc19900119.

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The extended Hammett eguaition Δ = ρs + hπ comprising the hydrophobic constant π is found to be effective in the title compounds and reactivities in various solvent mixtures. In 32 vol.% tert-butanol-water hmdecreases in the order ArCOOMe (-0.25), cis-ArCH=CHCOOH (-0.18), ArCOOH and ArCH2COOH (-0.16), ArCH2CH2COOH and trans-ArCH=CHCOOH (-0.07). For ArCOOH, mixtures like 40-60% methanol, 50% ethanol, 50% acetone and 50% dioxane give similar hm values of circa -0.05. For ArCH2COOH the effects of 3-iodo and 4-iodo substituents are acid-weakening in 32% tert-butanol. The consequences of the hπ term for ρ, σ, and the averaging of σ values, are discussed.

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43

Chao, Maria, Jean-Michel Chezal, Eric Debiton, et al. "A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs." Pharmaceuticals 15, no. 2 (2022): 162. http://dx.doi.org/10.3390/ph15020162.

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The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular interest. While radioiodinated derivatives, such as [123I]IMT, are easily available via electrophilic aromatic substitutions, the production of radiofluorinated aryl tyrosine analogs was a long-standing challenge for radiochemists before the development of innovative radiofluorination processes using arylboronate, arylstannane or iodoniums salts as precursors. Surprisingly, despite these methodological advances, no radiofluorinated analogs have been reported for [123I]8-iodo-L-TIC(OH), a very promising radiotracer for SPECT imaging of prostatic tumors. This work describes a convenient synthetic pathway to obtain new radioiodinated and radiofluorinated derivatives of TIC(OH), as well as their non-radiolabeled counterparts. Using organotin compounds as key intermediates, [125I]5-iodo-L-TIC(OH), [125I]6-iodo-L-TIC(OH) and [125I]8-iodo-L-TIC(OH) were efficiently prepared with good radiochemical yield (RCY, 51–78%), high radiochemical purity (RCP, >98%), molar activity (Am, >1.5–2.9 GBq/µmol) and enantiomeric excess (e.e. >99%). The corresponding [18F]fluoro-L-TIC(OH) derivatives were also successfully obtained by radiofluorination of the organotin precursors in the presence of tetrakis(pyridine)copper(II) triflate and nucleophilic [18F]F− with 19–28% RCY d.c., high RCP (>98.9%), Am (20–107 GBq/µmol) and e.e. (>99%).

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SHIV, P. SINGH, BATRA HITESH, K. SHARMA PAWAN, and PRAKASH OM. "A Facile Synthesis of 4-Pyrazolylthiazoles and 4-Pyrazolylmercaptoimidazoles using [Hydroxy(tosyloxy)iodo]benzene." Journal of Indian Chemical Society Vol. 74, Nov-Dec 1997 (1997): 940–42. https://doi.org/10.5281/zenodo.5900747.

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Department of Chemistry, Kurukshetra University, Kurukshetra-136 119 <em>Manuscript received 30 September 1997</em> Treatment of 4-acylpyrazoles with [hydroxy(tosyloxy)iodo]benzene gives 4-(α-tosyloxyaeetyl)pyrazole, which has been found to be an excellent intermediate for the synthesis of the title compounds.

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45

Salma, A., Sherbeni El, Tarek, F., and Moselhy El. "Computational Evaluation of the Druggability and Biological Activity of Iodo-1,4-dihydropyridine Derivatives." Chemistry Research Journal 2, no. 5 (2017): 131–41. https://doi.org/10.5281/zenodo.13950955.

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Several successful antihypertensive medicines already in clinical use are derivatives of 1,4-dihydropyridine (1,4-DHP). They are considered the most potent calcium channel blockers of which, nitro-, chloro- and fluro-1,4-DHP derivatives have been extensively investigated for biological activity [1-5]. Nevertheless, iodo-1,4-DHP derivatives have not received enough attention. Our aims were to evaluate the druglikeness and bioactivity of a new series of 2- & 3-iodophenyl-2,6-dimethyl-1,4-dihydropyridine derivatives using Molispiration software, as well as to dock these derivatives into the active domain of proteins [ion channel modulator (5KMH) and nuclear receptor ligand (5EWM)] using Molegro virtual docker. The compounds 2f, 2i, 2n, 3i and 3n were found to obey Lipinski’s rule and its extension and show good drug likeness, indicating good potential gastrointestinal permeability. Also, the bioactivity towards G protein–coupled receptors, ion channel, kinase, nuclear receptor and other enzyme targets was estimated for the tested compounds. The compounds 2c, 2h, 2m, 3c, 3h and 3m gave good docking scores especially against both ion channel modulator and nuclear receptor ligand, whereas, the other compounds had moderate bioactivities.  In conclusion, iodo-1,4-DHP derivatives give good druglikness and <em>in silico</em> bioactivity that justify subsequent synthesis and <em>in vivo</em> testing of these compounds.

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Sathiyapriya, R., and R. Joel Karunakaran. "Iodination of Alkylbenzenes using Benzyltriphenylphosphonium Dichromate / I2 System." E-Journal of Chemistry 6, no. 4 (2009): 1164–66. http://dx.doi.org/10.1155/2009/928040.

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An efficient and rapid method have been found using benzyltriphenylphosphonium dichromate (PhCH2PPh3)2Cr2O7as an oxidant along with molecular iodine for the iodination of aromatic compounds. Iodination of a wide variety of alkyl benzenes were done under dichloromethane solvent system and high yields of iodo products were obtained

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47

Al-Shuwaili, Thamer, Mushtak Talib Mohammadali, Adnan A. Lahuf, Manjree Agarwal, and Pushpendra Koli. "Study on metabolic response of female and male Trogoderma varia-bile (Ballion) on different host grain using direct immersion solid-phase microextraction coupled with gas chromatography mass." Journal of Kerbala for Agricultural Sciences 11, no. 1 (2024): 14–30. http://dx.doi.org/10.59658/jkas.v11i1.1426.

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The purpose of this study is to use the technique of gas chromatography coupled with mass spectrometry to study the metabolite profile of Trogoderma variabile using different host grains including canola, oats, wheat, and barley. Also, hydrocarbon profiling can be used as a chemo-taxonomical tool for insect species identification, especially for very morphologically similar species like T. granarium. For sample preparation insects were subjected to extraction with acetonitrile. Direct Immersion-Solid Phase Microextraction (DI-SPME) was employed, followed by Gas Chromatography-Mass Spectrometry analysis (GC-MS) for the collection, separation, and identification of compounds. Additionally, insect host grains have a significant effect on the insect chemicals that are identified from T. variabile adults such as fatty acid and hydrocarbons. Results showed that insect host grains have a significant influence on the chemical compounds that are identified in females and males. There were twenty-three compounds were identified from adults reared on canola and wheat. However, there were 26 and 28 compounds detected from adults reared on oats and barley respectively. Results also showed that 11-methylpentacosane; 13-methylheptacosane; heptacosane; docosane, 1-iodo- and nonacosane were the most significant compounds that identified form T. variabile male reared on different host grains. However, the main compounds identified from female cultured on different host grains include docosane, 1-iodo-; 1-butylamine, N-butyl-; oleic acid; heptacosane; 13-methylheptacosane; hexacosane; nonacosane; 2-methyloctacosane; n-hexadecanoic acid and docosane in the female samples.

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48

Jalilian, Ehsan, та Sven Lidin. "Dual graphs realized in the compounds di-μ3-4-mercaptopyridine catena-di-μ2-iodo-di-μ3-iodo-μ4-iodo penta copper(I) and di-μ3-4-mercaptopyridine-di-catena-iodo-di-μ3-iodo tri copper(I)". Journal of Solid State Chemistry 183, № 11 (2010): 2656–61. http://dx.doi.org/10.1016/j.jssc.2010.09.009.

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49

Chand, Deepak, and Jean'ne M. Shreeve. "Versatile polyiodopyrazoles: synthesis and biocidal promise." Chemical Communications 51, no. 16 (2015): 3438–41. http://dx.doi.org/10.1039/c4cc09775k.

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An efficient synthetic route provides ready access to polyiodopyrazoles, including 3,4,5-triiodopyrazole; further introduction of the diiodo-methyl group increases the iodine concentration which gives rise to anti bioagent detonation products I<sub>2</sub> and HI, making these iodo compounds promising candidates as ingredients in agent defeat weapons (ADWs).

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50

Nilsson, R., L. Ehrenberg, and I. Fedorcsak. "Formation of Potential Antigens from Radiographic Contrast Media." Acta Radiologica 28, no. 4 (1987): 473–77. http://dx.doi.org/10.1177/028418518702800420.

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The use of radiographic contrast media is occasionally accompanied by more or less serious adverse effects, evidently of complex etiology, following intravascular administration. Some of these reactions are suspected of having an allergic basis. The in vitro and in vivo formation of iodinated serum proteins following gamma irradiation in the presence of two commonly used radiographic contrast media is demonstrated. Non-toxic concentrations of ascorbate present during the irradiation is shown to prevent the formation of such iodo-proteins in vitro as well as in vivo. The amounts of potentially antigenic iodoprotein formed during radiographic procedures will certainly be very small, but this quantity may be sufficient to elicit a hypersensitivity reaction in cases when an individual has been previously sensitized to immunologically similar iodo-proteins, a mechanism that could account for certain rare and unpredictable reactions. The radiation induced formation of iodo-proteins may also serve as a model for the formation of iodine containing antigens mediated by a free radical mechanism, i.e. in the metabolism of iodinated compounds like erythrosine, a widely used colouring agent for certain foods.

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