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Journal articles on the topic 'Ion channels and transporters for potassium; sodium and water'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Zając, Mirosław, Andrzej Lewenstam, Magdalena Stobiecka, and Krzysztof Dołowy. "New ISE-Based Apparatus for Na+, K+, Cl−, pH and Transepithelial Potential Difference Real-Time Simultaneous Measurements of Ion Transport across Epithelial Cells Monolayer–Advantages and Pitfalls." Sensors 19, no. 8 (2019): 1881. http://dx.doi.org/10.3390/s19081881.

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Cystic Fibrosis (CF) is the most common fatal human genetic disease, which is caused by a defect in an anion channel protein (CFTR) that affects ion and water transport across the epithelium. We devised an apparatus to enable the measurement of concentration changes of sodium, potassium, chloride, pH, and transepithelial potential difference by means of ion-selective electrodes that were placed on both sides of a 16HBE14σ human bronchial epithelial cell line that was grown on a porous support. Using flat miniaturized ISE electrodes allows for reducing the medium volume adjacent to cells to app

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2

Bjerregaard, Henning F. "Side-specific Toxic Effects on the Membranes of Cultured Renal Epithelial Cells (A6)." Alternatives to Laboratory Animals 23, no. 4 (1995): 485–90. http://dx.doi.org/10.1177/026119299502300411.

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- A cultured epithelial cell line from toad kidney (A6) was used to investigate side-specific toxicity related to the apical (outer) and basolateral (inner) membranes of epithdia. Well-known inhibitors and stimulators of ion transport were used to show that the ion transport proteins are asymmetrically distributed: the apical membrane contains sodium and chloride channels and the basolateral membrane contains Na+/K+ pumps, Na+/Cl- co-transporters, potassium channels and receptors for antidiuretic hormone The data demonstrate that the cellular toxicity of chemicals decreases when they are added

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3

Collaco, Anne M., Robert L. Jakab, Nadia E. Hoekstra, Kisha A. Mitchell, Amos Brooks, and Nadia A. Ameen. "Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 3 (2013): G258—G275. http://dx.doi.org/10.1152/ajpgi.00485.2012.

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The Brunner's glands of the proximal duodenum exert barrier functions through secretion of glycoproteins and antimicrobial peptides. However, ion transporter localization, function, and regulation in the glands are less clear. Mapping the subcellular distribution of transporters is an important step toward elucidating trafficking mechanisms of fluid transport in the gland. The present study examined 1) changes in the distribution of intestinal anion transporters and the aquaporin 5 (AQP5) water channel in rat Brunner's glands following second messenger activation and 2) anion transporter distr

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4

Yuan, Dumin, Zhiyuan Ma, Biguang Tuo, Taolang Li, and Xuemei Liu. "Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer." Evidence-Based Complementary and Alternative Medicine 2020 (February 13, 2020): 1–10. http://dx.doi.org/10.1155/2020/2869138.

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Gastric cancer (GC) is a highly invasive and fatal malignant disease that accounts for 5.7% of new global cancer cases and is the third leading cause of cancer-related death. Acid/base homeostasis is critical for organisms because protein and enzyme function, cellular structure, and plasma membrane permeability change with pH. Various ion transporters are expressed in normal gastric mucosal epithelial cells and regulate gastric acid secretion, ion transport, and fluid absorption, thereby stabilizing the differentiation and homeostasis of gastric mucosal epithelial cells. Ion transporter dysfun

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5

Kang, Tong Mook, Vladislav S. Markin, and Donald W. Hilgemann. "Ion Fluxes in Giant Excised Cardiac Membrane Patches Detected and Quantified with Ion-selective Microelectrodes." Journal of General Physiology 121, no. 4 (2003): 325–48. http://dx.doi.org/10.1085/jgp.200208777.

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We have used ion-selective electrodes (ISEs) to quantify ion fluxes across giant membrane patches by measuring and simulating ion gradients on both membrane sides. Experimental conditions are selected with low concentrations of the ions detected on the membrane side being monitored. For detection from the cytoplasmic (bath) side, the patch pipette is oscillated laterally in front of an ISE. For detection on the extracellular (pipette) side, ISEs are fabricated from flexible quartz capillary tubing (tip diameters, 2–3 microns), and an ISE is positioned carefully within the patch pipette with th

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6

Nakamura, Kazuyoshi, Hikaru Hayashi, and Manabu Kubokawa. "Proinflammatory Cytokines and Potassium Channels in the Kidney." Mediators of Inflammation 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/362768.

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Proinflammatory cytokines affect several cell functions via receptor-mediated processes. In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. Among these, alteration of activity of potassium ion (K+) channels induces changes in transepithelial transport of solutes and water in the kidney, since K+channels in tubule cells are indispensable for formation of membrane potential which serves as a driving force for the transepithelial transport. Altered K+channel activity may be involved in renal cell dysfunction during inflammation. Althou

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Sopjani, Mentor, Lulzim Millaku, Dashnor Nebija, Merita Emini, Arleta Rifati-Nixha, and Miribane Dërmaku-Sopjani. "The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers." Current Medicinal Chemistry 26, no. 37 (2019): 6817–29. http://dx.doi.org/10.2174/0929867325666181009122452.

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Glycogen synthase kinase-3 (GSK-3) is a highly evolutionarily conserved and ubiquitously expressed serine/threonine kinase, an enzyme protein profoundly specific for glycogen synthase (GS). GSK-3 is involved in various cellular functions and physiological processes, including cell proliferation, differentiation, motility, and survival as well as glycogen metabolism, protein synthesis, and apoptosis. There are two isoforms of human GSK-3 (named GSK-3α and GSK-3β) encoded by two distinct genes. Recently, GSK-3β has been reported to function as a powerful regulator of various transport processes

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8

Shah, Binita, Dan Sindhikara, Ken Borrelli, and Abba E. Leffler. "Water Thermodynamics of Peptide Toxin Binding Sites on Ion Channels." Toxins 12, no. 10 (2020): 652. http://dx.doi.org/10.3390/toxins12100652.

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Peptide toxins isolated from venomous creatures, long prized as research tools due to their innate potency for ion channels, are emerging as drugs as well. However, it remains challenging to understand why peptide toxins bind with high potency to ion channels, to identify residues that are key for activity, and to improve their affinities via mutagenesis. We use WaterMap, a molecular dynamics simulation-based method, to gain computational insight into these three questions by calculating the locations and thermodynamic properties of water molecules in the peptide toxin binding sites of five io

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Praetorius, Jeppe, and Søren Nielsen. "Distribution of sodium transporters and aquaporin-1 in the human choroid plexus." American Journal of Physiology-Cell Physiology 291, no. 1 (2006): C59—C67. http://dx.doi.org/10.1152/ajpcell.00433.2005.

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The choroid plexus epithelium secretes electrolytes and fluid in the brain ventricular lumen at high rates. Several channels and ion carriers have been identified as likely mediators of this transport in rodent choroid plexus. This study aimed to map several of these proteins to the human choroid plexus. Immunoperoxidase-histochemistry was employed to determine the cellular and subcellular localization of the proteins. The water channel, aquaporin (AQP) 1, was predominantly situated in the apical plasma membrane domain, although distinct basolateral and endothelial immunoreactivity was also ob

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10

Askenasy, N., and G. Navon. "Volume-related activities of sodium ion transporters: multinuclear NMR studies of isolated rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 1 (1996): H94—H102. http://dx.doi.org/10.1152/ajpheart.1996.271.1.h94.

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The present study aims to determine the volume-related activities of sodium ion transporters in the rat heart. Intracellular volumes were measured in isolated hearts by 1H of water and 59Co nuclear magnetic resonance (NMR) of the extracellular marker cobalticyanide. Inhibition of the Na-K-adenosinetriphosphatase pumps with 50 microM ouabain did not affect the extent of cellular swelling during 30 min of ischemia: cells swelled by 0.37 ml/g dry wt compared with the controls (0.38 ml/g dry wt). After perfusion with 400 microM ouabain or 200 microM iodoacetate, the cells shrank during ischemia (f

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Kolb, Alexander R., Teresa M. Buck, and Jeffrey L. Brodsky. "Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function?" American Journal of Physiology-Renal Physiology 301, no. 1 (2011): F1—F11. http://dx.doi.org/10.1152/ajprenal.00141.2011.

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Ion channels, solute transporters, aquaporins, and factors required for signal transduction are vital for kidney function. Because mutations in these proteins or in associated regulatory factors can lead to disease, an investigation into their biogenesis, activities, and interplay with other proteins is essential. To this end, the yeast, Saccharomyces cerevisiae , represents a powerful experimental system. Proteins expressed in yeast include the following: 1) ion channels, including the epithelial sodium channel, members of the inward rectifying potassium channel family, and cystic fibrosis tr

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Féraille, Eric, and Alain Doucet. "Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control." Physiological Reviews 81, no. 1 (2001): 345–418. http://dx.doi.org/10.1152/physrev.2001.81.1.345.

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Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two-step mechanism: Na+-K+-ATPase-energized basolateral active extrusion of sodium permits passive apical entry through various sodium transport systems. In the past 15 years, most of the renal sodium transport systems (Na+-K+-ATPase, channels, cotransporters, and exchangers) have been characterized at a molecular level. Coupled to the methods developed during the 1965–1985 decades to circumvent kidney heterogeneity and

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13

Sacco, Riccardo, Giovanna Guidoboni, Joseph W. Jerome, et al. "A Theoretical Approach for the Electrochemical Characterization of Ciliary Epithelium." Life 10, no. 2 (2020): 8. http://dx.doi.org/10.3390/life10020008.

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The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for drug therapy in glaucoma, and therefore it is important to identify the main factors contributing to it. As several ion transporters have been hypothesized as relevant players in CE physiology, we propose a theoretical approach to complement experimental methods in characterizing their role in the electrochemical and fluid-dynamical conditions of CE. As a first step, we compare

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Watson, P. D. "Sieving of electrolytes at capillary wall of cat skeletal muscle by osmotic water flow." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 6 (1993): H1869—H1874. http://dx.doi.org/10.1152/ajpheart.1993.265.6.h1869.

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To test the hypothesis that a significant proportion of transcapillary water flow occurs through solute-restricting channels, we investigated the effects of transcapillary water movement on plasma electrolytes in isolated perfused cat skeletal muscle. The lower hindlimbs of anesthetized cats were perfused with a plasma-albumin solution and were weighed to determine transcapillary water movement. Osmolality was increased 60–70 mosmol/kgH2O with sucrose, creating water fluxes of 8–10 ml.min-1.100 g-1, and the changes in the venous concentrations of sodium, potassium, and chloride were determined

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15

Gonzalez-Perez, Vivian, Pedro L. Martinez-Espinosa, Monica Sala-Rabanal, et al. "Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice." Proceedings of the National Academy of Sciences 118, no. 3 (2021): e2019149118. http://dx.doi.org/10.1073/pnas.2019149118.

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Goblet cells (GCs) are specialized cells of the intestinal epithelium contributing critically to mucosal homeostasis. One of the functions of GCs is to produce and secrete MUC2, the mucin that forms the scaffold of the intestinal mucus layer coating the epithelium and separates the luminal pathogens and commensal microbiota from the host tissues. Although a variety of ion channels and transporters are thought to impact on MUC2 secretion, the specific cellular mechanisms that regulate GC function remain incompletely understood. Previously, we demonstrated that leucine-rich repeat-containing pro

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Capra, Janne P., and Sinikka M. Eskelinen. "MDCK cells are capable of water secretion and reabsorption in response to changes in the ionic environment." Canadian Journal of Physiology and Pharmacology 95, no. 1 (2017): 72–83. http://dx.doi.org/10.1139/cjpp-2016-0051.

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A prerequisite for tissue electrolyte homeostasis is highly regulated ion and water transport through kidney or intestinal epithelia. In the present work, we monitored changes in the cell and luminal volumes of type II Madin-Darby canine kidney (MDCK) cells grown in a 3D environment in response to drugs, or to changes in the composition of the basal extracellular fluid. Using fluorescent markers and high-resolution spinning disc confocal microscopy, we could show that lack of sodium and potassium ions in the basal fluid (tetramethylammonium chloride (TMACl) buffer) induces a rapid increase in

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Sandefur, Conner I., Richard C. Boucher, and Timothy C. Elston. "Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis." Proceedings of the National Academy of Sciences 114, no. 35 (2017): E7272—E7281. http://dx.doi.org/10.1073/pnas.1617383114.

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Mucociliary clearance is composed of three components (i.e., mucin secretion, airway surface hydration, and ciliary-activity) which function coordinately to clear inhaled microbes and other foreign particles from airway surfaces. Airway surface hydration is maintained by water fluxes driven predominantly by active chloride and sodium ion transport. The ion channels that mediate electrogenic ion transport are regulated by extracellular purinergic signals that signal through G protein-coupled receptors. These purinoreceptors and the signaling pathways they activate have been identified as possib

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18

Liu, Jinn-Liang, and Bob Eisenberg. "Molecular Mean-Field Theory of Ionic Solutions: A Poisson-Nernst-Planck-Bikerman Model." Entropy 22, no. 5 (2020): 550. http://dx.doi.org/10.3390/e22050550.

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We have developed a molecular mean-field theory—fourth-order Poisson–Nernst–Planck–Bikerman theory—for modeling ionic and water flows in biological ion channels by treating ions and water molecules of any volume and shape with interstitial voids, polarization of water, and ion-ion and ion-water correlations. The theory can also be used to study thermodynamic and electrokinetic properties of electrolyte solutions in batteries, fuel cells, nanopores, porous media including cement, geothermal brines, the oceanic system, etc. The theory can compute electric and steric energies from all atoms in a

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19

Chen, Lei, Yan Ding, Yapeng Hou, Yanhong Liu, and Hongguang Nie. "Regulation of Cl- Electrolyte Permeability in Epithelia by Active Traditional Chinese Medicine Monomers for Diarrhea." Current Drug Targets 21, no. 9 (2020): 902–9. http://dx.doi.org/10.2174/1389450121666200504073635.

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The epithelial layer, lining the inner surface of the mammalian alveolar, kidney, brain and colon, is a typical electrolyte transporting tissue. Large quantities of salt and fluid are actively moved from the mucosal side toward the blood vessel. Transepithelial salt re-absorption in epithelial tissues plays an important role in maintaining fluid homeostasis. In absorptive epithelium, fluid and salt flux is controlled by the machinery mainly composed of epithelial sodium channel, cystic fibrosis transmembrane conductance regulator, Na+-K+-2Cl- cotransporter, Na+/H+ exchanger, and Na+/K+-ATPase.

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Di Chiara, Marianna, Bob Glaudemans, Dominique Loffing-Cueni, et al. "Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney." American Journal of Physiology-Renal Physiology 309, no. 9 (2015): F779—F790. http://dx.doi.org/10.1152/ajprenal.00139.2015.

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The Rab GTPase-activating protein TBC1D4 (AS160) controls trafficking of the glucose transporter GLUT4 in adipocytes and skeletal muscle cells. TBC1D4 is also highly abundant in the renal distal tubule, although its role in this tubule is so far unknown. In vitro studies suggest that it is involved in the regulation of renal transporters and channels such as the epithelial sodium channel (ENaC), aquaporin-2 (AQP2), and the Na+-K+-ATPase. To assess the physiological role of TBC1D4 in the kidney, wild-type (TBC1D4+/+) and TBC1D4-deficient (TBC1D4−/−) mice were studied. Unexpectedly, neither unde

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Esquivel, Carlos J., Bryan J. Cassone, and Peter M. Piermarini. "Ade novotranscriptome of the Malpighian tubules in non-blood-fed and blood-fed Asian tiger mosquitoesAedes albopictus: insights into diuresis, detoxification, and blood meal processing." PeerJ 4 (March 10, 2016): e1784. http://dx.doi.org/10.7717/peerj.1784.

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Background.In adult female mosquitoes, the renal (Malpighian) tubules play an important role in the post-prandial diuresis, which removes excess ions and water from the hemolymph of mosquitoes following a blood meal. After the post-prandial diuresis, the roles that Malpighian tubules play in the processing of blood meals are not well described.Methods.We used a combination of next-generation sequencing (paired-end RNA sequencing) and physiological/biochemical assays in adult female Asian tiger mosquitoes (Aedes albopictus) to generate molecular and functional insights into the Malpighian tubul

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Li, Yizeng, Xiaohan Zhou, and Sean X. Sun. "Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation." Frontiers in Cell and Developmental Biology 9 (June 24, 2021). http://dx.doi.org/10.3389/fcell.2021.683686.

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Cells lacking a stiff cell wall, e.g., mammalian cells, must actively regulate their volume to maintain proper cell function. On the time scale that protein production is negligible, water flow in and out of the cell determines the cell volume variation. Water flux follows hydraulic and osmotic gradients; the latter is generated by various ion channels, transporters, and pumps in the cell membrane. Compared to the widely studied roles of sodium, potassium, and chloride in cell volume regulation, the effects of proton and bicarbonate are less understood. In this work, we use mathematical models

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Kotoda, Masakazu, Sohei Hishiyama, Tadahiko Ishiyama, Kazuha Mitsui, and Takashi Matsukawa. "Amiodarone exacerbates brain injuries after hypoxic–ischemic insult in mice." BMC Neuroscience 20, no. 1 (2019). http://dx.doi.org/10.1186/s12868-019-0544-2.

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Abstract Background Sodium ion transportation plays a crucial role in the pathogenesis of hypoxic–ischemic brain injury. Amiodarone, a Vaughan-Williams class III antiarrhythmic drug, has been widely used to treat life-threatening arrhythmia and cardiac arrest worldwide. In addition to its inhibitory effects on the potassium channel, amiodarone also blocks various sodium ion transporters, including the voltage-gated sodium channel, sodium pump, and Na+/Ca+ exchanger. Considering these pharmacological profile, amiodarone may affect the influx–efflux balance of sodium ion in the hypoxic–ischemic

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Ji, Min Jeong, Hee Jung Ryu, and Jeong Hee Hong. "Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in Synoviocytes." Frontiers in Cell and Developmental Biology 9 (August 31, 2021). http://dx.doi.org/10.3389/fcell.2021.700879.

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Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation of the synovial membrane ultimately leading to permanent damage in the affected joints. For this study, synovial fluids from 16 patients diagnosed with either RA or osteoarthritis (OA) were used to examine volume regulation and cooperative water channels, both of which are involved in the cytotoxic edema identified in RA-fibroblast-like synoviocytes (FLS). The osmolarity and inflammatory cytokine interleukin (IL)-6 of synovial fluids from RA patients were mildly enhanced compared to that from OA patients. RA-FLS demons

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Bortner, Carl D., and John A. Cidlowski. "Ions, the Movement of Water and the Apoptotic Volume Decrease." Frontiers in Cell and Developmental Biology 8 (November 25, 2020). http://dx.doi.org/10.3389/fcell.2020.611211.

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The movement of water across the cell membrane is a natural biological process that occurs during growth, cell division, and cell death. Many cells are known to regulate changes in their cell volume through inherent compensatory regulatory mechanisms. Cells can sense an increase or decrease in their cell volume, and compensate through mechanisms known as a regulatory volume increase (RVI) or decrease (RVD) response, respectively. The transport of sodium, potassium along with other ions and osmolytes allows the movement of water in and out of the cell. These compensatory volume regulatory mecha

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Kamata, Satomi, Maki Kimura, Sadao Ohyama, Shuichiro Yamashita, and Yoshiyuki Shibukawa. "Large-Conductance Calcium-Activated Potassium Channels and Voltage-Dependent Sodium Channels in Human Cementoblasts." Frontiers in Physiology 12 (April 20, 2021). http://dx.doi.org/10.3389/fphys.2021.634846.

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Cementum, which is excreted by cementoblasts, provides an attachment site for collagen fibers that connect to the alveolar bone and fix the teeth into the alveolar sockets. Transmembrane ionic signaling, associated with ionic transporters, regulate various physiological processes in a wide variety of cells. However, the properties of the signals generated by plasma membrane ionic channels in cementoblasts have not yet been described in detail. We investigated the biophysical and pharmacological properties of ion channels expressed in human cementoblast (HCEM) cell lines by measuring ionic curr

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Lueck, John D., Adam L. Mackey, Daniel T. Infield, et al. "Atomic mutagenesis in ion channels with engineered stoichiometry." eLife 5 (October 6, 2016). http://dx.doi.org/10.7554/elife.18976.

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C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppression to highlight the role of the conserved Trp434-Asp447 indole hydrogen bond in Shaker potassium channels with a non-hydrogen bonding homologue of tryptophan, Ind (<xref ref-type="bibr" rid="bib36">Pless et al., 2013</xref>). Here, molecular dynamics simulations indicate that the Trp434Ind hydrogen bonding partner, Asp447, unexpected

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Trifonova, Natalia, Maria Koroleva, and Elena Fedorova. "Some aspects of metal ion transport and in silico gene expression analysis of potassium/sodium ion transporters, channels and exchangers in root nodules." Biological Communications 66, no. 1 (2021). http://dx.doi.org/10.21638/spbu03.2021.107.

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Rhizobia establish a symbiotic relationship with legumes, which results in the formation of root nodules, the ecological niche for intracellular rhizobia. The infected cell of a root nodule is a special integral unit of plant and nitrogen fixing rhizobia. Nodules tend to be very sensitive to ionic stresses, such as salt stress. High vulnerability toward ionic stresses might be due to defects in ion balance and transport in the infected tissue. The purpose of this minireview is to summarize the current data regarding metal ion transport in the root nodule, with particular emphasis on potassium/

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Wang, Delong, Xuke Lu, Xiugui Chen, et al. "Temporal salt stress-induced transcriptome alterations and regulatory mechanisms revealed by PacBio long-reads RNA sequencing in Gossypium hirsutum." BMC Genomics 21, no. 1 (2020). http://dx.doi.org/10.1186/s12864-020-07260-z.

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Abstract Background Cotton (Gossypium hirsutum) is considered a fairly salt tolerant crop however, salinity can still cause significant economic losses by affecting the yield and deteriorating the fiber quality. We studied a salt-tolerant upland cotton cultivar under temporal salt stress to unfold the salt tolerance molecular mechanisms. Biochemical response to salt stress (400 mM) was measured at 0 h, 3 h, 12 h, 24 h and 48 h post stress intervals and single-molecule long-read sequencing technology from Pacific Biosciences (PacBio) combined with the unique molecular identifiers approach was u

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Shiozaki, Atsushi, Yoshinori Marunaka, and Eigo Otsuji. "Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers." Frontiers in Cell and Developmental Biology 9 (March 11, 2021). http://dx.doi.org/10.3389/fcell.2021.616933.

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Ion and water channels were recently shown to be involved in cancer cell functions, and various transporter types have been detected in upper gastrointestinal tract (UGI) cancers. Current information on the expression and roles of these channels and transporters in the death and survival of UGI cancer cells was reviewed herein, and the potential of their regulation for cancer management was investigated. Esophageal cancer (EC) and gastric cancer (GC) cells and tissues express many different types of ion channels, including voltage-gated K+, Cl–, and Ca2+, and transient receptor potential (TRP)

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Negoro, Takumi, Keisuke Hirata, James M. Lisy, Shun-ichi Ishiuchi, and Masaaki Fujii. "Potassium and sodium ion complexes with a partial peptide of the selectivity filter in K+ channels studied by cold ion trap infrared spectroscopy: the effect of hydration." Physical Chemistry Chemical Physics, 2021. http://dx.doi.org/10.1039/d1cp00936b.

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Cryogenic infrared spectra with quantum chemical calculations have revealed significant structural differences between K<sup>+</sup> and Na<sup>+</sup>, bound to a partial peptide of the selectivity filter of a K<sup>+</sup> channel following hydration by a single water molecule.

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Neverisky, Daniel L., and Geoffrey W. Abbott. "Abstract 231: Uncovering the Mechanism and Function of Newly Discovered KCNQ1-Transporter Complexes." Circulation Research 115, suppl_1 (2014). http://dx.doi.org/10.1161/res.115.suppl_1.231.

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The KCNQ1 voltage-gated potassium channel is essential for human ventricular repolarization, permitting potassium efflux from excited cardiomyocytes to end each action potential and repolarize the heart. In cardiomyocytes, KCNQ1 is modulated by interaction with beta-subunits from the KCNE gene family, each of which significantly alters KCNQ1 channel function. KCNQ1 mutations are the most common identified genetic basis for Long QT syndrome (LQTS) and are also associated with lone atrial fibrillation (AF). The sodium-dependent myo-inositol transporter 1 (SMIT1) mediates cellular uptake of myo-i

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Saha, Sudip, A. H. M. Selim Reza, and Mrinal Kanti Roy. "Hydrochemical evaluation of groundwater quality of the Tista floodplain, Rangpur, Bangladesh." Applied Water Science 9, no. 8 (2019). http://dx.doi.org/10.1007/s13201-019-1085-7.

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Abstract The Tista is a Trans-Himalayan river that flows through Sikkim and West Bengal states of India and Rangpur division of Bangladesh and finally falls into the Brahmaputra River. The presence of numerous abandoned channels with various degrees of aggradations indicates large migrations of the Tista River. The pH value of groundwater varies from 6.20 to 7.40 which indicate the slightly alkaline to acidic nature of the studied aquifers. The mean abundance of major cations is Na+ > Ca+2 > Mg+2 > K+, whereas the major anions is HCO3− > Cl− > SO4−2. Among the cations, Na+ is th

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Arow, M., M. Waldman, D. Yadin, et al. "Sodium–glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy." Cardiovascular Diabetology 19, no. 1 (2020). http://dx.doi.org/10.1186/s12933-019-0980-4.

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Abstract Background Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but there is no specific therapy for diabetic heart disease. Sodium glucose transporter 2 inhibitors (SGLT2I) are recently developed diabetic drugs that primarily work on the kidney. Clinical data describing the cardiovascular benefits of SGLT2Is highlight the potential therapeutic benefit of these drugs in the prevention of cardiovascular events and heart failure. However, the underlying mechanism of protection remains unclear. We investigated the effect of Dapagliflozin—SGLT2I, on diabetic cardio

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Hellas, Julia A., and R. David Andrew. "Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization." Neurocritical Care, September 8, 2021. http://dx.doi.org/10.1007/s12028-021-01326-w.

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AbstractAn acute reduction in plasma osmolality causes rapid uptake of water by astrocytes but not by neurons, whereas both cell types swell as a consequence of lost blood flow (ischemia). Either hypoosmolality or ischemia can displace the brain downwards, potentially causing death. However, these disorders are fundamentally different at the cellular level. Astrocytes osmotically swell or shrink because they express functional water channels (aquaporins), whereas neurons lack functional aquaporins and thus maintain their volume. Yet both neurons and astrocytes immediately swell when blood flow

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Chen, Zhu, David P. Adams, Michael J. Vasile, et al. "A Novel Design Toward Understanding and Characterizing Transport Behavior of Composite Mesoporous Silica Thin Films." MRS Proceedings 921 (2006). http://dx.doi.org/10.1557/proc-0921-t05-29.

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AbstractResearch in synthetic materials with controlled transport properties has been inspired by the exquisite selectivity exhibited by natural transmembrane proteins such as ion channels (for selectively transporting ions like sodium and potassium, etc) and aquaporins (for conducting high fluxes of water and excluding ions). In this poster we focus on the transport behavior of highly ordered mesoporous silica thin films synthesized by evaporation induced silica/surfactant self-assembly (EISA). This process allows us to integrate the nanostructures into electronic and fluidic systems by simpl

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