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Journal articles on the topic 'Ion channels and transporters for potassium'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Demirbilek, Huseyin, Sonya Galcheva, Dogus Vuralli, Sara Al-Khawaga, and Khalid Hussain. "Ion Transporters, Channelopathies, and Glucose Disorders." International Journal of Molecular Sciences 20, no. 10 (2019): 2590. http://dx.doi.org/10.3390/ijms20102590.

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Ion channels and transporters play essential roles in excitable cells including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, for example, potassium KATP channels link the metabolic signals generated inside the cell to changes in the beta-cell membrane potential, and ultimately regulate insulin secretion. Mutations in the genes encoding some ion transporter and channel proteins lead to disorders of glucose homeostasis (hyperinsulinaemic hypoglycaemia and different forms of diabetes mellitus). Pancreatic KATP, Non-KATP, and some calcium chann

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2

Yuan, Dumin, Zhiyuan Ma, Biguang Tuo, Taolang Li, and Xuemei Liu. "Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer." Evidence-Based Complementary and Alternative Medicine 2020 (February 13, 2020): 1–10. http://dx.doi.org/10.1155/2020/2869138.

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Gastric cancer (GC) is a highly invasive and fatal malignant disease that accounts for 5.7% of new global cancer cases and is the third leading cause of cancer-related death. Acid/base homeostasis is critical for organisms because protein and enzyme function, cellular structure, and plasma membrane permeability change with pH. Various ion transporters are expressed in normal gastric mucosal epithelial cells and regulate gastric acid secretion, ion transport, and fluid absorption, thereby stabilizing the differentiation and homeostasis of gastric mucosal epithelial cells. Ion transporter dysfun

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3

Nakamura, Kazuyoshi, Hikaru Hayashi, and Manabu Kubokawa. "Proinflammatory Cytokines and Potassium Channels in the Kidney." Mediators of Inflammation 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/362768.

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Proinflammatory cytokines affect several cell functions via receptor-mediated processes. In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. Among these, alteration of activity of potassium ion (K+) channels induces changes in transepithelial transport of solutes and water in the kidney, since K+channels in tubule cells are indispensable for formation of membrane potential which serves as a driving force for the transepithelial transport. Altered K+channel activity may be involved in renal cell dysfunction during inflammation. Althou

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4

Akyuz, Enes, Zuleyha Doganyigit, Yam Nath Paudel, et al. "Immunoreactivity of Muscarinic Acetylcholine M2 and Serotonin 5-HT2B Receptors, Norepinephrine Transporter and Kir Channels in a Model of Epilepsy." Life 11, no. 4 (2021): 276. http://dx.doi.org/10.3390/life11040276.

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Epilepsy is characterized by an imbalance in neurotransmitter activity; an increased excitatory to an inhibitory activity. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K+) concentration via K+ ion channels. Seizures may disrupt the regulation of inwardly rectifying K+ (Kir) channels and alter the receptor/transporter activity. However, there are limited data present on the immunoreactivity pattern of these neurotransmitter receptors/t

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Sopjani, Mentor, Lulzim Millaku, Dashnor Nebija, Merita Emini, Arleta Rifati-Nixha, and Miribane Dërmaku-Sopjani. "The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers." Current Medicinal Chemistry 26, no. 37 (2019): 6817–29. http://dx.doi.org/10.2174/0929867325666181009122452.

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Glycogen synthase kinase-3 (GSK-3) is a highly evolutionarily conserved and ubiquitously expressed serine/threonine kinase, an enzyme protein profoundly specific for glycogen synthase (GS). GSK-3 is involved in various cellular functions and physiological processes, including cell proliferation, differentiation, motility, and survival as well as glycogen metabolism, protein synthesis, and apoptosis. There are two isoforms of human GSK-3 (named GSK-3α and GSK-3β) encoded by two distinct genes. Recently, GSK-3β has been reported to function as a powerful regulator of various transport processes

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6

Feng, Xinghua, Zhuangzhuang Zhao, Qian Li, and Zhiyong Tan. "Lysosomal Potassium Channels: Potential Roles in Lysosomal Function and Neurodegenerative Diseases." CNS & Neurological Disorders - Drug Targets 17, no. 4 (2018): 261–66. http://dx.doi.org/10.2174/1871527317666180202110717.

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Background & Objective: The lysosome is a membrane-enclosed organelle widely found in every eukaryotic cell. It has been deemed as the stomach of the cells. Recent studies revealed that it also functions as an intracellular calcium store and is a platform for nutrient-dependent signal transduction. Similar with the plasma membrane, the lysosome membrane is furnished with various proteins, including pumps, ion channels and transporters. So far, two types of lysosomal potassium channels have been identified: large-conductance and Ca2+-activated potassium channel (BK) and TMEM175. TMEM175 has

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7

Quraishi, Imran H., and Robert M. Raphael. "Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells." American Journal of Physiology-Cell Physiology 292, no. 1 (2007): C591—C602. http://dx.doi.org/10.1152/ajpcell.00560.2005.

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Cochlear marginal cells and vestibular dark cells transport potassium into the inner ear endolymph, a potassium-rich fluid, the homeostasis of which is essential for hearing and balance. We have formulated an integrated mathematical model of ion transport across these epithelia that incorporates the biophysical properties of the major ion transporters and channels located in the apical and basolateral membranes of the constituent cells. The model is constructed for both open- and short-circuit situations to test the extremes of functional capacity of the epithelium and predicts the steady-stat

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8

Kolb, Alexander R., Teresa M. Buck, and Jeffrey L. Brodsky. "Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function?" American Journal of Physiology-Renal Physiology 301, no. 1 (2011): F1—F11. http://dx.doi.org/10.1152/ajprenal.00141.2011.

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Ion channels, solute transporters, aquaporins, and factors required for signal transduction are vital for kidney function. Because mutations in these proteins or in associated regulatory factors can lead to disease, an investigation into their biogenesis, activities, and interplay with other proteins is essential. To this end, the yeast, Saccharomyces cerevisiae , represents a powerful experimental system. Proteins expressed in yeast include the following: 1) ion channels, including the epithelial sodium channel, members of the inward rectifying potassium channel family, and cystic fibrosis tr

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9

Kang, Tong Mook, Vladislav S. Markin, and Donald W. Hilgemann. "Ion Fluxes in Giant Excised Cardiac Membrane Patches Detected and Quantified with Ion-selective Microelectrodes." Journal of General Physiology 121, no. 4 (2003): 325–48. http://dx.doi.org/10.1085/jgp.200208777.

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We have used ion-selective electrodes (ISEs) to quantify ion fluxes across giant membrane patches by measuring and simulating ion gradients on both membrane sides. Experimental conditions are selected with low concentrations of the ions detected on the membrane side being monitored. For detection from the cytoplasmic (bath) side, the patch pipette is oscillated laterally in front of an ISE. For detection on the extracellular (pipette) side, ISEs are fabricated from flexible quartz capillary tubing (tip diameters, 2–3 microns), and an ISE is positioned carefully within the patch pipette with th

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10

Agarkova, Irina, David Dunigan, James Gurnon, et al. "Chlorovirus-Mediated Membrane Depolarization of Chlorella Alters Secondary Active Transport of Solutes." Journal of Virology 82, no. 24 (2008): 12181–90. http://dx.doi.org/10.1128/jvi.01687-08.

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ABSTRACT Paramecium bursaria chlorella virus 1 (PBCV-1) is the prototype of a family of large, double-stranded DNA, plaque-forming viruses that infect certain eukaryotic chlorella-like green algae from the genus Chlorovirus. PBCV-1 infection results in rapid host membrane depolarization and potassium ion release. One interesting feature of certain chloroviruses is that they code for functional potassium ion-selective channel proteins (Kcv) that are considered responsible for the host membrane depolarization and, as a consequence, the efflux of potassium ions. This report examines the relations

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Rosati, Barbara, Min Dong, Lan Cheng, et al. "Evolution of ventricular myocyte electrophysiology." Physiological Genomics 35, no. 3 (2008): 262–72. http://dx.doi.org/10.1152/physiolgenomics.00159.2007.

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The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, however, the role of regulatory evolution has received less attention or has been considered to be relatively unimportant. To address this issue for electrophysiological systems, we examined the importance of regulatory and structural evolution in the evolution of the electrophysi

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12

Gonzalez-Perez, Vivian, Pedro L. Martinez-Espinosa, Monica Sala-Rabanal, et al. "Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice." Proceedings of the National Academy of Sciences 118, no. 3 (2021): e2019149118. http://dx.doi.org/10.1073/pnas.2019149118.

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Goblet cells (GCs) are specialized cells of the intestinal epithelium contributing critically to mucosal homeostasis. One of the functions of GCs is to produce and secrete MUC2, the mucin that forms the scaffold of the intestinal mucus layer coating the epithelium and separates the luminal pathogens and commensal microbiota from the host tissues. Although a variety of ion channels and transporters are thought to impact on MUC2 secretion, the specific cellular mechanisms that regulate GC function remain incompletely understood. Previously, we demonstrated that leucine-rich repeat-containing pro

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13

Denton, Jerod S., Alan C. Pao, and Merritt Maduke. "Novel diuretic targets." American Journal of Physiology-Renal Physiology 305, no. 7 (2013): F931—F942. http://dx.doi.org/10.1152/ajprenal.00230.2013.

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As the molecular revolution continues to inform a deeper understanding of disease mechanisms and pathways, there exist unprecedented opportunities for translating discoveries at the bench into novel therapies for improving human health. Despite the availability of several different classes of antihypertensive medications, only about half of the 67 million Americans with hypertension manage their blood pressure appropriately. A broader selection of structurally diverse antihypertensive drugs acting through different mechanisms would provide clinicians with greater flexibility in developing effe

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Sacco, Riccardo, Giovanna Guidoboni, Joseph W. Jerome, et al. "A Theoretical Approach for the Electrochemical Characterization of Ciliary Epithelium." Life 10, no. 2 (2020): 8. http://dx.doi.org/10.3390/life10020008.

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The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for drug therapy in glaucoma, and therefore it is important to identify the main factors contributing to it. As several ion transporters have been hypothesized as relevant players in CE physiology, we propose a theoretical approach to complement experimental methods in characterizing their role in the electrochemical and fluid-dynamical conditions of CE. As a first step, we compare

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Wang, Meng, Ugur Eskiocak, Michalis Agathokleous, Stacy Yuan, Charles Crawley, and Sean J. Morrison. "Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia." Blood 126, no. 23 (2015): 1264. http://dx.doi.org/10.1182/blood.v126.23.1264.1264.

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Abstract Background The generation and maintenance of electrochemical gradients by ion transporters are vital in almost all cellular processes. Ion transporters are often dysregulated in cancer cells and play important roles in cancer cell function. For example, aberrant expression of voltage gated potassium channels Kv10.1 (Eag1) and Kv11.1, (hERG) have been associated with increased proliferation and worse prognosis in hematological malignancies. Targeting ion transporters may thus offer a novel therapeutic strategy against cancer. To this end, we identified ion transporters that when inhibi

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Garcia, Kevin, Carmen Guerrero-Galán, Hannah E. R. Frank, et al. "Fungal Shaker-like channels beyond cellular K+ homeostasis: A role in ectomycorrhizal symbiosis between Hebeloma cylindrosporum and Pinus pinaster." PLOS ONE 15, no. 11 (2020): e0242739. http://dx.doi.org/10.1371/journal.pone.0242739.

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Potassium (K+) acquisition, translocation and cellular homeostasis are mediated by various membrane transport systems in all organisms. We identified and described an ion channel in the ectomycorrhizal fungus Hebeloma cylindrosporum (HcSKC) that harbors features of animal voltage-dependent Shaker-like K+ channels, and investigated its role in both free-living hyphae and symbiotic conditions. RNAi lines affected in the expression of HcSKC were produced and used for in vitro mycorrhizal assays with the maritime pine as host plant, under standard or low K+ conditions. The adaptation of H. cylindr

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Bjerregaard, Henning F. "Side-specific Toxic Effects on the Membranes of Cultured Renal Epithelial Cells (A6)." Alternatives to Laboratory Animals 23, no. 4 (1995): 485–90. http://dx.doi.org/10.1177/026119299502300411.

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- A cultured epithelial cell line from toad kidney (A6) was used to investigate side-specific toxicity related to the apical (outer) and basolateral (inner) membranes of epithdia. Well-known inhibitors and stimulators of ion transport were used to show that the ion transport proteins are asymmetrically distributed: the apical membrane contains sodium and chloride channels and the basolateral membrane contains Na+/K+ pumps, Na+/Cl- co-transporters, potassium channels and receptors for antidiuretic hormone The data demonstrate that the cellular toxicity of chemicals decreases when they are added

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18

Findlay, Geoffrey P. "Membranes and the electrophysiology of turgor regulation." Functional Plant Biology 28, no. 7 (2001): 619. http://dx.doi.org/10.1071/pp01026.

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In many types of plant and algal cells, the turgor is regulated, either at a constant level, or in some reproducible time-dependent way. This review considers the electrophysiology of turgor control in marine algae, guard cells, and motor cells of pulvini. There is a basic complement of electrophysiological components in the plasma membranes of these cells. These components are responsible for controlling the fluxes of potassium salts, the major inorganic component of the osmoticum responsible for changing internal osmotic pressure, and hence turgor, and consist essentially of inwardly and out

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Zając, Mirosław, Andrzej Lewenstam, Magdalena Stobiecka, and Krzysztof Dołowy. "New ISE-Based Apparatus for Na+, K+, Cl−, pH and Transepithelial Potential Difference Real-Time Simultaneous Measurements of Ion Transport across Epithelial Cells Monolayer–Advantages and Pitfalls." Sensors 19, no. 8 (2019): 1881. http://dx.doi.org/10.3390/s19081881.

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Cystic Fibrosis (CF) is the most common fatal human genetic disease, which is caused by a defect in an anion channel protein (CFTR) that affects ion and water transport across the epithelium. We devised an apparatus to enable the measurement of concentration changes of sodium, potassium, chloride, pH, and transepithelial potential difference by means of ion-selective electrodes that were placed on both sides of a 16HBE14σ human bronchial epithelial cell line that was grown on a porous support. Using flat miniaturized ISE electrodes allows for reducing the medium volume adjacent to cells to app

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Wilson, Zachary N., Amber L. Scott, Robin D. Dowell, and Greg Odorizzi. "PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation." Molecular Biology of the Cell 29, no. 14 (2018): 1718–31. http://dx.doi.org/10.1091/mbc.e18-01-0015.

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Lysosomes are dynamic organelles with critical roles in cellular physiology. The lysosomal signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a key regulator that has been implicated to control lysosome ion homeostasis, but the scope of ion transporters targeted by PI(3,5)P2 and the purpose of this regulation is not well understood. Through an unbiased screen in Saccharomyces cerevisiae, we identified loss-of-function mutations in the vacuolar H+-ATPase (V-ATPase) and in Vnx1, a vacuolar monovalent cation/proton antiporter, as suppressor mutations that relieve the growth defe

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21

Chérel, Isabelle, and Isabelle Gaillard. "The Complex Fine-Tuning of K+ Fluxes in Plants in Relation to Osmotic and Ionic Abiotic Stresses." International Journal of Molecular Sciences 20, no. 3 (2019): 715. http://dx.doi.org/10.3390/ijms20030715.

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As the main cation in plant cells, potassium plays an essential role in adaptive responses, especially through its involvement in osmotic pressure and membrane potential adjustments. K+ homeostasis must, therefore, be finely controlled. As a result of different abiotic stresses, especially those resulting from global warming, K+ fluxes and plant distribution of this ion are disturbed. The hormone abscisic acid (ABA) is a key player in responses to these climate stresses. It triggers signaling cascades that ultimately lead to modulation of the activities of K+ channels and transporters. After a

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22

Collaco, Anne M., Robert L. Jakab, Nadia E. Hoekstra, Kisha A. Mitchell, Amos Brooks, and Nadia A. Ameen. "Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 3 (2013): G258—G275. http://dx.doi.org/10.1152/ajpgi.00485.2012.

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The Brunner's glands of the proximal duodenum exert barrier functions through secretion of glycoproteins and antimicrobial peptides. However, ion transporter localization, function, and regulation in the glands are less clear. Mapping the subcellular distribution of transporters is an important step toward elucidating trafficking mechanisms of fluid transport in the gland. The present study examined 1) changes in the distribution of intestinal anion transporters and the aquaporin 5 (AQP5) water channel in rat Brunner's glands following second messenger activation and 2) anion transporter distr

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Boyd-Shiwarski, Cary R., Claire J. Weaver, Rebecca T. Beacham, et al. "Effects of extreme potassium stress on blood pressure and renal tubular sodium transport." American Journal of Physiology-Renal Physiology 318, no. 6 (2020): F1341—F1356. http://dx.doi.org/10.1152/ajprenal.00527.2019.

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We characterized mouse blood pressure and ion transport in the setting of commonly used rodent diets that drive K+ intake to the extremes of deficiency and excess. Male 129S2/Sv mice were fed either K+-deficient, control, high-K+ basic, or high-KCl diets for 10 days. Mice maintained on a K+-deficient diet exhibited no change in blood pressure, whereas K+-loaded mice developed an ~10-mmHg blood pressure increase. Following challenge with NaCl, K+-deficient mice developed a salt-sensitive 8 mmHg increase in blood pressure, whereas blood pressure was unchanged in mice fed high-K+ diets. Notably,

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Cai, Fang, Armen V. Gyulkhandanyan, Michael B. Wheeler, and Denise D. Belsham. "Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin." Journal of Endocrinology 192, no. 3 (2007): 605–14. http://dx.doi.org/10.1677/joe-06-0080.

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The mammalian hypothalamus comprises an array of phenotypically distinct cell types that interpret peripheral signals of energy status and, in turn, elicits an appropriate response to maintain energy homeostasis. We used a clonal representative hypothalamic cell model expressing proopiomelanocortin (POMC; N-43/5) to study changes in AMP-activated protein kinase (AMPK) activity and glucose responsiveness. We have demonstrated the presence of cellular machinery responsible for glucose sensing in the cell line, including glucokinase, glucose transporters, and appropriate ion channels. ATP-sensiti

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Alonso-Gardón, Marta, Xabier Elorza-Vidal, Aida Castellanos, et al. "Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins." Human Molecular Genetics 30, no. 17 (2021): 1649–65. http://dx.doi.org/10.1093/hmg/ddab155.

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Abstract Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a type of vacuolating leukodystrophy, which is mainly caused by mutations in MLC1 or GLIALCAM. The two MLC-causing genes encode for membrane proteins of yet unknown function that have been linked to the regulation of different chloride channels such as the ClC-2 and VRAC. To gain insight into the role of MLC proteins, we have determined the brain GlialCAM interacting proteome. The proteome includes different transporters and ion channels known to be involved in the regulation of brain homeostasis, proteins related to

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Gamba, Gerardo. "Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension." American Journal of Physiology-Renal Physiology 288, no. 2 (2005): F245—F252. http://dx.doi.org/10.1152/ajprenal.00311.2004.

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A recently discovered family of protein kinases is responsible for an autosomal-dominant disease known as Gordon's syndrome or pseudohypoaldosteronism type II (PHA-II) that features hyperkalemia and hyperchloremic metabolic acidosis, accompanied by hypertension and hypercalciuria. Four genes have been described in this kinase family, which has been named WNK, due to the absence of a key lysine in kinase subdomain II (with no K kinases). Two of these genes, WNK1 and WNK4 located in human chromosomes 12 and 17, respectively, are responsible for PHA-II. Immunohystochemical analysis revealed that

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Sedensky, M. M., J. M. Siefker, and P. G. Morgan. "Model Organisms: New Insights Into Ion Channel and Transporter Function. Stomatin homologues interact inCaenorhabditis elegans." American Journal of Physiology-Cell Physiology 280, no. 5 (2001): C1340—C1348. http://dx.doi.org/10.1152/ajpcell.2001.280.5.c1340.

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In C. elegans the protein UNC-1 is a major determinant of anesthetic sensitivity and is a close homologue of the mammalian protein stomatin. In humans stomatin is missing from erythrocyte membranes in the hemolytic disease overhydrated hereditary stomatocytosis, despite an apparently normal stomatin gene. Overhydrated hereditary stomatocytosis is characterized by alteration of the normal transmembrane gradients of sodium and potassium. Stomatin has been shown to interact genetically with sodium channels. It is also postulated that stomatin is important in the organization of lipid rafts. We de

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Yang, Yuhong, Martina Tetti, Twinkle Vohra, et al. "BEX1 Is Differentially Expressed in Aldosterone-Producing Adenomas and Protects Human Adrenocortical Cells From Ferroptosis." Hypertension 77, no. 5 (2021): 1647–58. http://dx.doi.org/10.1161/hypertensionaha.120.16774.

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Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism. Somatic mutations in ion channels and transporters drive the aldosterone overproduction in the majority of APAs with mutations in the KCNJ5 G protein-coupled potassium channel predominating in most reported populations. Our objective was to gain insight into biological mechanisms of APA tumorigenesis by comparing transcriptomes of APAs of distinct sizes by mRNA sequencing analysis (9 APAs with adenoma diameter ≥30 mm versus 12 APAs ≤10 mm). Genes with significantly altered expression levels between these 2 groups

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Mattson, M. P. "Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives." Physiological Reviews 77, no. 4 (1997): 1081–132. http://dx.doi.org/10.1152/physrev.1997.77.4.1081.

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beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a multifunctional protein that is widely expressed in the nervous system. beta-Amyloid precursor protein is axonally transported and accumulates in presynaptic terminals and growth cones. A secreted form of beta-APP (sAPP alpha) is released from neurons in response to electrical activity and may function in modulation of neuronal excitability, synaptic plasticity, neurite outgrowth, synaptogenesis, and cell survival. A sign

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Ulfat, Mobina, Habib-ur-Rehman Athar, Zaheerud-din Khan, and Hazem M. Kalaji. "RNAseq Analysis Reveals Altered Expression of Key Ion Transporters Causing Differential Uptake of Selective Ions in Canola (Brassica napus L.) Grown under NaCl Stress." Plants 9, no. 7 (2020): 891. http://dx.doi.org/10.3390/plants9070891.

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Salinity is one of the major abiotic stresses prevailing throughout the world that severely limits crop establishment and production. Every crop has an intra-specific genetic variation that enables it to cope with variable environmental conditions. Hence, this genetic variability is a good tool to exploit germplasms in salt-affected areas. Further, the selected cultivars can be effectively used by plant breeders and molecular biologists for the improvement of salinity tolerance. In the present study, it was planned to identify differential expression of genes associated with selective uptake o

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31

Wine, Jeffrey J. "Ion channels and transmembrane transporters." Current Biology 3, no. 2 (1993): 118–20. http://dx.doi.org/10.1016/0960-9822(93)90170-s.

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Roux, Benoît, Simon Bernèche, Bernhard Egwolf, et al. "Ion selectivity in channels and transporters." Journal of General Physiology 137, no. 5 (2011): 415–26. http://dx.doi.org/10.1085/jgp.201010577.

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Supanchart, Chayarop, and Uwe Kornak. "Ion channels and transporters in osteoclasts." Archives of Biochemistry and Biophysics 473, no. 2 (2008): 161–65. http://dx.doi.org/10.1016/j.abb.2008.03.029.

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Stock, Christian, and Albrecht Schwab. "Ion channels and transporters in metastasis." Biochimica et Biophysica Acta (BBA) - Biomembranes 1848, no. 10 (2015): 2638–46. http://dx.doi.org/10.1016/j.bbamem.2014.11.012.

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Coates, Leighton. "Ion permeation in potassium ion channels." Acta Crystallographica Section D Structural Biology 76, no. 4 (2020): 326–31. http://dx.doi.org/10.1107/s2059798320003599.

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The study of ion channels dates back to the 1950s and the groundbreaking electrophysiology work of Hodgin and Huxley, who used giant squid axons to probe how action potentials in neurons were initiated and propagated. More recently, several experiments using different structural biology techniques and approaches have been conducted to try to understand how potassium ions permeate through the selectivity filter of potassium ion channels. Two mechanisms of permeation have been proposed, and each of the two mechanisms is supported by different experiments. The key structural biology experiments c

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Grewer, Christof, and Armanda Gameiro. "How do Glutamate Transporters Function as Transporters and Ion Channels?" Biophysical Journal 107, no. 3 (2014): 546–47. http://dx.doi.org/10.1016/j.bpj.2014.06.027.

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Ando, Hideaki, Katsuhiro Kawaai, and Katsuhiko Mikoshiba. "IRBIT: A regulator of ion channels and ion transporters." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843, no. 10 (2014): 2195–204. http://dx.doi.org/10.1016/j.bbamcr.2014.01.031.

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Kim, Gheun Ho. "Ion Channels and Transporters in Renal Tubules." Korean Journal of Electrolyte Metabolism 1, no. 1 (2003): 31. http://dx.doi.org/10.5049/kjem.2003.1.1.31.

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Stock, Christian, and Albrecht Schwab. "How ion channels and transporters affect metastasis." Physiology News, Spring 2006 (April 1, 2006): 19–20. http://dx.doi.org/10.36866/pn.62.19.

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Schwab, Albrecht. "Ion Channels and Transporters on the Move." Physiology 16, no. 1 (2001): 29–33. http://dx.doi.org/10.1152/physiologyonline.2001.16.1.29.

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Cell migration plays a crucial role in a variety of (patho)physiological processes such as immune defense, wound healing, and formation of tumor metastases. Detailed models have been developed to describe cytoskeletal mechanisms of migration. However, evidence is accumulating that the activity of ion channels and transporters is also required for optimal cell locomotion.

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41

Ravens, Ursula, Erich Wettwer, and Ottó Hála. "Pharmacological modulation of ion channels and transporters." Cell Calcium 35, no. 6 (2004): 575–82. http://dx.doi.org/10.1016/j.ceca.2004.01.011.

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Harvey, Alan L. "Neuropharmacology of potassium ion channels." Medicinal Research Reviews 13, no. 1 (1993): 81–104. http://dx.doi.org/10.1002/med.2610130104.

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Noskov, Sergei Yu, and Benoît Roux. "Ion selectivity in potassium channels." Biophysical Chemistry 124, no. 3 (2006): 279–91. http://dx.doi.org/10.1016/j.bpc.2006.05.033.

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Wright, Angela J., Susan E. Matthews, Wolfgang B. Fischer, and Paul D. Beer. "Novel Resorcin[4]arenes as Potassium-Selective Ion-Channel and Transporter Mimics." Chemistry - A European Journal 7, no. 16 (2001): 3474. http://dx.doi.org/10.1002/1521-3765(20010817)7:16<3474::aid-chem3474>3.0.co;2-6.

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Shimoni, Y. "Hormonal control of cardiac ion channels and transporters." Progress in Biophysics and Molecular Biology 72, no. 1 (1999): 67–108. http://dx.doi.org/10.1016/s0079-6107(99)00005-x.

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Becchetti, Andrea. "Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer." American Journal of Physiology-Cell Physiology 301, no. 2 (2011): C255—C265. http://dx.doi.org/10.1152/ajpcell.00047.2011.

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Progress through the cell mitotic cycle requires precise timing of the intrinsic molecular steps and tight coordination with the environmental signals that maintain a cell into the proper physiological context. Because of their great functional flexibility, ion channels coordinate the upstream and downstream signals that converge on the cell cycle machinery. Both voltage- and ligand-gated channels have been implicated in the control of different cell cycle checkpoints in normal as well as neoplastic cells. Ion channels mediate the calcium signals that punctuate the mitotic process, the cell vo

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Bentrup, Friedrich-Wilhelm. "Potassium ion channels in the plasmalemma." Physiologia Plantarum 79, no. 4 (1990): 705–11. http://dx.doi.org/10.1034/j.1399-3054.1990.790420.x.

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Bentrup, Friedrich-Wilhelm. "Potassium ion channels in the plasmalemma." Physiologia Plantarum 79, no. 4 (1990): 705–11. http://dx.doi.org/10.1111/j.1399-3054.1990.tb00048.x.

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Kopfer, David A., Chen Song, Ulrich Zachariae, and Bert L. de Groot. "Ion Permeation Efficiency through Potassium Channels." Biophysical Journal 106, no. 2 (2014): 539a. http://dx.doi.org/10.1016/j.bpj.2013.11.3005.

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50

Schwab, Albrecht. "Function and spatial distribution of ion channels and transporters in cell migration." American Journal of Physiology-Renal Physiology 280, no. 5 (2001): F739—F747. http://dx.doi.org/10.1152/ajprenal.2001.280.5.f739.

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Abstract:

Cell migration plays a central role in many physiological and pathophysiological processes, such as embryogenesis, immune defense, wound healing, or the formation of tumor metastases. Detailed models have been developed that describe cytoskeletal mechanisms of cell migration. However, evidence is emerging that ion channels and transporters also play an important role in cell migration. The purpose of this review is to examine the function and subcellular distribution of ion channels and transporters in cell migration. Topics covered will be a brief overview of cytoskeletal mechanisms of migrat

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