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Dissertations / Theses on the topic 'Ion chromatography/ Mass Spectrometry'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Al-Omair, Ali Saleh. "Ion chromatography/mass spectrometry : development and characterization." Thesis, University of Kent, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257141.

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2

Lu, Yao. "Forensic Applications of Gas Chromatography-Differential Mobility Spectrometry, Gas Chromatography/Mass Spectrometry, and Ion Mobility Spectrometry with Chemometric Analysis." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1267816777.

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3

Gilchrist, Elizabeth Sarah. "Ion chromatography and ion chromatography-high resolution mass spectrometry technologies for the analysis of low-order explosive residues." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/ion-chromatography-and-ion-chromatographyhigh-resolution-mass-spectrometry-technologies-for-the-analysis-of-loworder-explosive-residues(8b6c406d-97f2-4fe3-9739-0decc5ef26d3).html.

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The development of chromatographic methods for the detection of low molecular weight organic acids and inorganic anions found in low-order explosive residues are presented. The work is divided into six sections. Firstly, Chapter 1 provides a background on low-order explosives and fingermarks. Existing methods for the analysis of these sample types, focussing on ion chromatography (IC) and mass spectrometry (MS) technologies, are reviewed. Gaps in knowledge are highlighted and the aims and objectives of the thesis presented and justified towards addressing these challenges. Chapter 2 applies an

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4

Silwal, Indira K. C. "Characterization of Unknown Chemicals Using Gas Chromatography/Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and AB-Initio Calculations." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/SilwalIKC2008.pdf.

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5

Adams, Kendra J. "Discovery and Targeted Monitoring of Biomarkers Using Liquid Chromatography, Ion Mobility Spectrometry , and Mass Spectrometry." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3568.

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The complexity of biological matrices makes the detection and quantification of compounds of interest challenging. For successful targeted or untargeted identification of compounds within a biological environment, the use of complementary separation techniques is routinely required; in many situations, a single analytical technique is not sufficient. In the present dissertation, a multidimensional analytical technique was developed and evaluated, a combination of new sample preparation/extraction protocols, liquid chromatography, trapped ion mobility and mass spectrometry (e.g., LC-TIMS-MS and

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6

Xia, Yang. "Chromatography coupled with mass spectrometry in bioanalysis." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/27998.

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7

Luo, Zhaohui. "GC/FT-ICR Mass Spectral Analysis of Complex Mixtures: A Multidimensional Approach for Online Gas Phase Basicity Measurements." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/LuoZX2006.pdf.

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8

Ismail, Vian Sdiq Ismail. "Probing lipidation of membrane active peptides and integral membrane proteins by liquid chromatography-mass spectrometry and ion mobility separation-mass spectrometry." Thesis, Durham University, 2017. http://etheses.dur.ac.uk/12424/.

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Liquid chromatography coupled with mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS2) are shown to have the sensitivity and functionality to detect protein/peptide modifications by fatty acyl chains in vitro and in vivo studies. Further analysis was also performed by direct infusion ion mobility separation coupled with mass spectrometry (IMS-MS) or tandem mass spectrometry (IMS-MS2). Peptide lipidation in vitro was investigated using the membrane active peptide, melittin. Non-enzymatic melittin lipidation by lysophospholipids has been observed for the first time. When the effect o

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9

Alabbas, Alhumaidi. "Reversed-phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry in Characterization of Glycosaminoglycans." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3547.

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Glycosaminoglycans (GAGs) are a family of linear bio-polysaccharides, which are heterogeneously modified with negatively charged sulfate and carboxylate groups. They are located on every cell surface, extracellular matrix or intracellular space in the body. GAGs are composed of alternating units of an amino sugars (glucosamine or galactosamine) and hexuronic acid/hexose (iduronic acid, glucoronic acid/ or galactose), which are linked by glycosidic bonds with different geometries. In recent years, GAGs have attracted considerable interest. GAGs play vital roles in fundamental biological process

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10

Arthur, Kayleigh L. "The development and application of miniaturised FAIMS combined with mass spectrometry in bioanalysis." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/27724.

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In this thesis, a miniaturised field asymmetric waveform ion mobility spectrometry (FAIMS) device is combined with mass spectrometry (MS), and liquid chromatography, for the development and application of bioanalytical methodologies. FAIMS is a highly orthogonal to MS and LC and has the potential to enhance both targeted and non-targeted bioanalytical applications. Chapter two demonstrates the capability of the FAIMS combined with mass spectrometry to reduce the complexity of the mass spectrum by separating species of different charge states and overlapping mass-to-charge ratios that are chall

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11

Ramström, Margareta. "Analysis of Complex Biological Samples using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Doctoral thesis, Uppsala University, Analytical Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5729.

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<p>Studies of protein and peptide expression are vital in order to understand complex biological systems. As demonstrated in this thesis, on-line packed capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS) is a useful analytical tool for such studies.</p><p>A proteomics method, based on global tryptic digestion and subsequent separation and detection of the peptides by LC-FTICR MS, was developed for qualitative analysis of body fluids. Initial experiments on cerebrospinal fluid (CSF) provided results that were comparable or superior to those

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12

Wenner, Brett Romain. "METHODS DEVELOPMENT AND APPLICATION OF TWO DIMENSIONAL CHROMATOGRAPHY AND TANDEM MASS SPECTROMETRY IN PROTEOMICS." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/281.

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Although molybdenum blue solutions have been known for more than twocenturies, an understanding of their chemical nature is only beginning to emerge.This dissertation aimed at elucidating the structural nature of the polydisperse,nanoscopic components in the solution phases and the solid states of partiallyreduced polyoxomolybdate (Mo-POM). The study offered at least fourcontributions to the area: (1) a rational protocol for the molecular recognition ofMo-POM with de novo organic hosts. (2) demonstration of kinetic precipitation ofa dynamic mixture of polyoxomolybdates and application of the t

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13

Katzenmeyer, Bryan C. "Interfacing Liquid Chromatography or Ion Mobility Separation with Mult-Dimensional Mass Spectrometry for the Structural Characterization of Polymeric Materials." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1367252830.

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14

Smiljanic, Danijela. "Mass Spectrometry Interfaced with Ion Mobility or Liquid Chromatography Separation for the Analysis of Complex Mixtures." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1323149449.

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15

Murray, Jacolin Ann. "High Flow Air Sampling for Field Detection Using Gas Chromatography-Mass Spectrometry." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2414.

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The ability to rapidly detect and identify hazardous analytes in the field has become increasingly important. One of the most important analytical detection methods in the field is gas chromatography-mass spectrometry (GC-MS). In this work, a hand-portable GC-MS system is described that contains a miniature toroidal ion trap mass analyzer and a low thermal mass GC. The system is self-contained within the dimensions of 47 x 36 x 18 cm and weighs less than 13 kg. Because the instrument has a small footprint, it was used as the detector for an automated near-real-time permeation testing system. I

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16

Zhang, Liwen. "Characterization of histone post-translational modification using reversed-phase high performance liquid chromatography and fourier transform ion cyclotron resonance mass spectrometry." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054660495.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 219 p.; also includes graphics (some col.) Includes bibliographical references (p. 147-173). Available online via OhioLINK's ETD Center

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17

Hutton, K. A. "A study of capillary liquid chromatography-ion trap mass spectrometry for the analysis of drug metabolites : the effect of acridone derivatisation on peptide tandem mass spectrometry." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637362.

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This work discusses two applications of mass spectrometry in the pharmaceutical industry: capillary liquid chromatography/ion trap mass spectrometry of drugs and metabolites; and tandem mass spectrometry of derivatised peptides. A capillary liquid chromatography system was successfully coupled to an ion trap mass spectrometer using atmospheric pressure chemical ionisation. In order to do this a make-up liquid had to be added to provide sufficient flow for ionisation. A four-fold improvement in sensitivity was obtained over conventional liquid chromatography/mass spectrometry using atmospheric

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18

Tsybin, Youri. "High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Doctoral thesis, Uppsala universitet, Jonfysik, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4136.

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Advances in science and technology during the past decade have greatly enhanced the level of the structural investigation of macromolecules – peptides and proteins. Biological mass spectrometry has become one of the most precise and sensitive techniques in peptide and protein analysis. However, increasing demands of biotechnological applications require further progress to be made. In the present thesis the development and improvement of peptide and protein characterization methods and techniques based on ion-electron and ion-photon reactions in electrospray ionization Fourier transform ion cy

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19

Fan, Wen. "Improved Dynamic Headspace Sampling and Detection using Capillary Microextraction of Volatiles Coupled to Gas Chromatography Mass Spectrometry." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/982.

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Sampling and preconcentration techniques play a critical role in headspace analysis in analytical chemistry. My dissertation presents a novel sampling design, capillary microextraction of volatiles (CMV), that improves the preconcentration of volatiles and semivolatiles in a headspace with high throughput, near quantitative analysis, high recovery and unambiguous identification of compounds when coupled to mass spectrometry. The CMV devices use sol-gel polydimethylsiloxane (PDMS) coated microglass fibers as the sampling/preconcentration sorbent when these fibers are stacked into open-ended cap

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20

De, Vos Betty-Jayne. "Gas chromatography coupled with ion trap mass spectrometry (GC-MS and GC-MS-MS) - for arson debris analysis." Diss., Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-02082006-160506.

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21

Proschogo, Nicholas William Chemistry Faculty of Science UNSW. "Identification of mammalian lipid material by high performance liquid chromatography and fourier transform ion cyclotron resonance mass spectrometry." Publisher:University of New South Wales. Chemistry, 2008. http://handle.unsw.edu.au/1959.4/42914.

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The analysis of the exact compositions of human lipids is of great importance and can lead to a better understanding of the role of lipids in heart diseases and diabetes. Reverse phase and normal phase high performance liquid chromatography has been used for the analysis of lipid material and applied to beef dripping. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry has been used to investigate the free fatty acids, monoacylglycerides, diacylglycerides and triacylglycerides present in lard and beef dripping with the general conclusion that this is a semi quan

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22

Chang, Chih-Hsiang. "Proteomic studies on protein N-terminus and peptide ion mobility by nano-scale liquid chromatography/tandem mass spectrometry." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263596.

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23

Solak, Nilüfer. "Structural Characterization and Quantitative Analysis by Interfacing Liquid Chromatography and/or Ion Mobility Separation with Multi-Dimensional Mass Spectrometry." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1270744150.

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24

Ponnusamy, Pooja. "Reverse-phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry In Characterization And Fingerprinting Of Diverse Sulfated Glycosaminoglycan Mimetics." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3031.

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Heparin is a highly sulfated glycosaminoglycan with potent anticoagulant, antimetastatic, and anti-inflammatory effects. Polymeric and polyanionic nature of heparin makes dosing and side effects a nightmare for healthcare professionals. Our laboratory has proposed appropriately designed, small, highly sulfated aromatic molecules as potential mimetics of heparin. These easier-to-synthesize small molecules have been shown to possess interesting pharmacological and improved toxicological profiles. However, the detection and characterization of these highly sulfated molecules is challenging. A ro

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25

Harper, Carla Jo. "Development and application of an on-line liquid chromatography interface for the analysis of biomolecules by Fourier transform ion cyclotron resonance mass spectrometry /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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26

Knee, Jose. "Determining the metabolic profiles in Drosophila melanogaster: Development and application of a novel ion-pairing liquid chromatography-mass spectrometry protocol." Thesis, Laurentian University of Sudbury, 2014. https://zone.biblio.laurentian.ca/dspace/handle/10219/2138.

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Genetic perturbations and foreign chemicals can result in a multitude of changes across a wide range of biochemical processes in a biological system. These perturbations may affect the metabolome, the small molecule metabolites in an organism. Recently, liquid-chromatography coupled to mass spectrometry (LC-MS) technology has been used to quantify large proportions of the metabolome, however standardized protocols are not yet available for use with Drosophila melanogaster. Here, I developed an ion-pairing LC-MS protocol for the metabolomic characterization of D. melanogaster and demonstrated i

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27

Crosswhite, Mark Ray. "High-performance liquid chromatography electrospray ionization fourier transform ion cyclotron resonance mass spectrometry of citrus extract structural probing of flavonoids /." Tallahassee, Fla. : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-11092009-161703/.

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Thesis (M.S.)--Florida State University, 2009.<br>Advisor: Alan G. Marshall, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Mar. 1, 2010). Document formatted into pages; contains x, 51 pages. Includes bibliographical references.

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28

Brown, Stacy D., Justin D. Connor, Nicholas C. Smallwood, and Ralph A. Lugo. "Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/5308.

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An LC-MS/MS method was developed and validated to be used as a stability indicating assay for the study of a 3 mg/mL lansoprazole oral suspension. The method utilizes a UPLC (ultra-performance liquid chromatography) column and unique mass spectrometric detection (ion-trap time-of-flight (IT-TOF)) to achieve a sensitive (LOD 2 ng/mL), accurate, and reproducible quantification of lansoprazole. This method reports an intraday and interday coefficient of variation of 2.98 ± 2.17% ( for each concentration for each day) and 3.07 ± 0.89% ( for each concentration), respectively. Calibration curves (5–

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29

Wang, Yan. "Laser Desorption Solid Phase Microextraction." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/1283.

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The use of laser desorption as a sample introduction method for solid phase microextraction (SPME) has been investigated in this research project. Three different types of analytical instruments, mass spectrometry (MS), ion mobility spectrometry (IMS) and gas chromatography (GC) were employed as detectors. The coupling of laser desorption SPME to these three instruments was constructed and described in here. <br /><br /> Solid phase microextraction/surface enhanced laser desorption ionization fibers (SPME/SELDI) were developed and have been coupled to two IMS devices. SPME/SELDI combin

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30

Hagman, Charlotte. "Method Development in Quantitative and Structural Proteomics using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Doctoral thesis, Uppsala University, Department of Engineering Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4761.

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<p>In this thesis, methods for studying different aspects of proteomics were developed with Fourier Transform Ion Cyclotron Resonance, (FTICR), mass spectrometry. The FTICR technique provides ultra-high mass resolving power, mass accuracy at sub ppm level and sensitivity in the attomole region.</p><p>Methods for quantifying biomarkers in body fluids such as cerebrospinal fluid, (CSF), and plasma were developed. Two sets of global markers with different properties were used for quantitative analysis; S-Methyl Thioacetimidate, (SMTA), and S-Methyl Thiopropionimidate, (SMTP), and [H<sub>4</sub>]-

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31

Nezami, Ranjbar Mohammad Rasoul. "Novel Preprocessing and Normalization Methods for Analysis of GC/LC-MS Data." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73499.

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We introduce new methods for preprocessing and normalization of data acquired by gas/liquid chromatography coupled with mass spectrometry (GC/LC-MS). Normalization is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences. There are different sources of experimental bias including variabilities in sample collection, sample storage, poor experimental design, noise, etc. Also, instrument variability in experiments involving a large number of runs leads to a significant drift in intensity measurements. We propose n

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32

Cook, Shannon L. "Metastable Atom-Activated Dissociation (MAD): A Novel Dissociation Method Employed within a Quadrupole Ion Trap Mass Spectrometer." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1331325173.

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33

Palmblad, Magnus. "Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Doctoral thesis, Uppsala universitet, Institutionen för materialvetenskap, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1999.

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Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. This thesis concerns how useful information on proteins of interest can be extracted from mass spectrometric data on different levels of protein structure and how to obtain this data expe

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34

Mokhtari-Fard, Ahmad Chemistry Faculty of Science UNSW. "Method development in electrospray ionisation fourier transform ion cyclotron resonance mass spectrometry study of plant oils - macadamia oil as a model." Publisher:University of New South Wales. Chemistry, 2008. http://handle.unsw.edu.au/1959.4/43114.

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A novel analytical method is developed to examine the chemical composition of plant oils by electrospray ionisation high-resolution Fourier transform ion cyclotron resonance mass spectrometry in both positive- and negative-ion modes. To date, this is the first reported application of this technique for the study of macadamia nut oil. Samples of macadamia nut oil from the Macadamia Integrifolia- Proteaceae family (smooth shell) are examined. The fatty acid profile of the oil is obtained by this mass spectrometric examination of the transesterified and hydrolysed oil samples. The Fourier transfo

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35

Alawani, Nadrah. "Structural Characterization of Synthetic Polymers and Copolymers Using Multidimensional Mass Spectrometry Interfaced with Thermal Degradation, Liquid Chromatography and/or Ion Mobility Separation." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1386591497.

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36

Yasin, Mohammed. "Environmental monitoring of pesticides in components of river systems - method development and analysis by gas chromatography negative-ion chemical ionization mass spectrometry." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308379.

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37

Collin, Olivier L. "Development of a Novel Tandem Mass Spectrometry Technique for Forensic and Biological Applications." View abstract, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3292877.

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38

Evers, Frank Richard. "Development of a liquid chromatography ion trap mass spectrometer method for clinical drugs of abuse testing with automated on-line extraction using turbulent flow chromatography." Thesis, University of Portsmouth, 2014. https://researchportal.port.ac.uk/portal/en/theses/development-of-a-liquid-chromatography-ion-trap-mass-spectrometer-method-for-clinical-drugs-of-abuse-testing-with-automated-online-extraction-using-turbulent-flow-chromatography(c047da7d-eb8a-41d0-ad1c-830deca531dc).html.

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Aims The method for the confirmation of drugs of abuse for addiction testing within King’s College Hospital prior to 2008 was a labour intensive thin layer chromatography method. To replace this with a faster method more suited to future requirements, the laboratory bought a liquid chromatography system with ion trap mass spectrometric detection. The development of the routine analytical method and the implementation of this method within the laboratory using on-line solid phase extraction and Turboflow® sample preparation will allow the laboratory to operate successfully in the field of clini

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39

Joshi-Kumar, Monica. "Headspace Analysis of Smokeless Powders: Development of Mass Calibration Methods using Microdrop Printing for Chromatographic and Ion Mobility Spectrometric Detection." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/150.

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Smokeless powder additives are usually detected by their extraction from post-blast residues or unburned powder particles followed by analysis using chromatographic techniques. This work presents the first comprehensive study of the detection of the volatile and semi-volatile additives of smokeless powders using solid phase microextraction (SPME) as a sampling and pre-concentration technique. Seventy smokeless powders were studied using laboratory based chromatography techniques and a field deployable ion mobility spectrometer (IMS). The detection of diphenylamine, ethyl and methyl centralite,

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40

Svilar, Ljubica. "Structural elucidation of secondary metabolites from Hypoxylon fragiforme, using high resolution mass spectrometry and gas-phase ion-molecule reactions." Paris 6, 2012. http://www.theses.fr/2012PA066468.

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Fungi produce a wide variety of biologically active compounds/metabolites that could be used for medicinal and pharmaceutical purposes. Mitorubrines, members of the family of azaphilones, constitute a particularly interesting set of structurally diverse secondary metabolites, exhibiting a wide range of biological activities (e. G. Antimicrobial, antibacterial, antimalarial). This work describes the development of several mass spectrometry-based approaches to solve the natural structural diversity and complexity of azaphilones extracted from Hypoxylon fragiforme fungus. The first part of this m

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41

Murch, Sarah Louise. "The role of liquid chromatography-high resolution mass spectrometry in the diagnosis and treatment of substance misuse." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-liquid-chromatographyhigh-resolution-mass-spectrometry-in-the-diagnosis-and-treatment-of-substance-misuse(e155a5b7-6155-4416-9516-6ea54e048a3b).html.

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Substance misuse remains problematic with current concerns being the rise in acute poisoning deaths, particularly opioid-associated, and the ever-widening range of drugs available. Strategies for tackling opioid addiction and opioid related-deaths include researching alternative routes of therapeutic agent administration. Initial urine screening for substance misuse has traditionally employed immunoassays, with confirmation of specific analytes by chromatographic methods. Liquid chromatography-high resolution mass spectrometry (LC-HRMS) offers untargeted analysis without compromising selectivi

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42

Philipp, Anika-Anina Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Studies on the phase I and II metabolism and the toxicological analysis of the alkaloids of the herbal drug of abuse Mitragyna speciosa Korth. (Kratom) using gas chromatography-mass spectrometry and liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry / Anika-Anina Philipp. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051284848/34.

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Ghosson, Hikmat. "Development of a novel universal proxy to assess the environmental fate and impact of complex (bio)pesticides by Mass Spectrometry-based Metabolomics." Electronic Thesis or Diss., Perpignan, 2020. http://www.theses.fr/2020PERP0029.

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Malgré la prise de conscience écologique et sanitaire, la consommation mondiale de pesticides est en augmentation. Étant donné que ces produits chimiques présentent de nombreux effets néfastes sur la santé humaine et l'environnement, des mesures doivent être prises afin de limiter leurs effets. Les produits de biocontrôle sont proposés comme une solution alternative aux produits synthétiques. En effet, ces « biopesticides » sont présumés être moins nocifs et relativement moins persistants. Toutefois, cet a priori doit être examiné et une évaluation stricte des risques de ces nouvelles substanc

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44

Mendes, Siqueira Anna Luiza. "Apport de la spectrométrie de mobilité ionique couplée à la spectrométrie de masse pour la caractérisation de produits pétroliers formulés." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR044.

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Les produits pétroliers formulés actuels tels que les carburants et les lubrifiants doiventrépondre à des cahiers des charges bien précis pour garantir les meilleures performances,fiabilité et longévité des moteurs tout en limitant l’émission de polluants. Ce travail de thèse porte sur le développement de méthodologies d’analyse pour l’identification d’additifs polymériques dans les gazoles et la caractérisation des polyalphaoléfines. L’analyse des additifs a été effectuée par couplage de la chromatographie liquide, de la spectrométrie de mobilité ionique et de la spectrométrie de masse (LC-IM

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45

Jones, Christina Michele. "Applications and challenges in mass spectrometry-based untargeted metabolomics." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54830.

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Metabolomics is the methodical scientific study of biochemical processes associated with the metabolome—which comprises the entire collection of metabolites in any biological entity. Metabolome changes occur as a result of modifications in the genome and proteome, and are, therefore, directly related to cellular phenotype. Thus, metabolomic analysis is capable of providing a snapshot of cellular physiology. Untargeted metabolomics is an impartial, all-inclusive approach for detecting as many metabolites as possible without a priori knowledge of their identity. Hence, it is a valuable explorato

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Hanley, Traci A. "Trace Elemental Methodologies for the Chromatographic Speciation of Silver Ions and Silver Nanoparticles and the Development of Rice Flour Internal Quality Control Material for Arsenic Speciation Applications using High Performance Liquid Chromatography." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491898753606019.

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Zhang, Wei. "Development of Photochemically Initiated Direct and Indirect Luminescence Detection Methods for Liquid Chromatography (LC) and Study of Aromatic Sulfonates and Phospholipids Using Reversed Phase Ion-Pair LC-Mass Spectrometry." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068739487.

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Handley, Simon Alfred. "Measurement of hepcidin-20, -22, -24, and -25 in human serum by liquid chromatography-high resolution-mass spectrometry and its clinical application." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/measurement-of-hepcidin20-22-24-and25-in-human-serum-by-liquid-chromatographyhigh-resolutionmass-spectrometry-and-its-clinical-application(469cf3da-46c9-4450-8f55-c878941a1abd).html.

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Hepcidin-25 is regarded as the master regulator of iron homeostasis. Three N-truncated isoforms of hepcidin-25 have been identified in human serum; hepcidin-20, -22, and -24, although information is scant as to the serum concentrations of these isoforms. A liquid chromatography-high resolution-mass spectrometry (LC-HR-MS) assay was developed for the simultaneous quantitation of hepcidin isoforms in human serum. Serum (200 μL) was mixed with aqueous formic acid (600 μL), and the supernatant loaded onto a 96-well- SPE-plate. Eluted sample (70 μL) was diluted with deionised water (60 μL) and anal

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Dadi, Hala. "Analyse par spectrométrie de masse des tubulines et de l'hormone de croissance." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS582.

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Les tubulines sont des protéines impliquées dans des processus biologiques essentiels à la vie cellulaire. Elles sont polymodifiées en leurs extrémités C-terminales. Différentes techniques ont été utilisées pour caractériser les polymodifications des tubulines. Mais certaines difficultés persistent concernant l’indentification fine de plusieurs structures. Le couplage de spectrométrie de masse à la mobilité ionique représente une avancée technique plus pertinente pour la séparation d’isomères de structures. En effet, la mobilité ionique peut séparer des ions de même rapport m/z en fonction de

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Agbonkonkon, Nosa. "Counter-flow Ion Mobility Analysis: Design, Instrumentation, and Characterization." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2136.pdf.

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