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1

SCHMITZ, R., L. BÜTFERING, and F. W. RÖLLGEN. "NEGATIVE ION IMAGING IN FIELD ION MICROSCOPY." Le Journal de Physique Colloques 47, no. C7 (1986): C7–53—C7–57. http://dx.doi.org/10.1051/jphyscol:1986710.

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2

Zhu, Cheng, Kaixiang Huang, Yunong Wang, Kristen Alanis, Wenqing Shi, and Lane A. Baker. "Imaging with Ion Channels." Analytical Chemistry 93, no. 13 (2021): 5355–59. http://dx.doi.org/10.1021/acs.analchem.1c00224.

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3

Levi-Setti, R., J. M. Chabala, C. Girod-Hallegot, P. Hallegot, and Y. L. Wang. "Secondary ion imaging microanalysis." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 8–9. http://dx.doi.org/10.1017/s042482010015201x.

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The goals of high spatial resolution and high elemental sensitivity in the imaging microanalysis of biological tissues and materials have, to a large extent, been attained by using the method of secondary ion mass spectrometry (SIMS) following bombardment of a sample surface by a focused beam of heavy ions. The instrument that we will discuss and which has achieved these goals is a scanning ion microprobe originally developed in collaboration with Hughes Research Laboratories (UC-HRL SIM). It utilizes a 40-60 keV Ga+ probe, extracted from a point-like liquid metal ion source, that can be focus
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4

Gröner, E., and P. Hoppe. "Automated ion imaging with the NanoSIMS ion microprobe." Applied Surface Science 252, no. 19 (2006): 7148–51. http://dx.doi.org/10.1016/j.apsusc.2006.02.280.

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5

Bolsover, Stephen R. "Ratio imaging of intracellular ion concentration." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (1992): 1160–61. http://dx.doi.org/10.1017/s0424820100130432.

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The field of intracellular ion concentration measurement expanded greatly in the 1980's due primarily to the development by Roger Tsien of ratiometric fluorescence dyes. These dyes have many applications, and in particular they make possible to image ion concentrations: to produce maps of the ion concentration within living cells. Ion imagers comprise a fluorescence microscope, an imaging light detector such as a video camera, and a computer system to process the fluorescence signal and display the map of ion concentration.Ion imaging can be used for two distinct purposes. In the first, the im
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6

Collins-Fekete, Charles-Antoine, Nikolaos Dikaios, Esther Bär, and Philip M. Evans. "Statistical limitations in ion imaging." Physics in Medicine & Biology 66, no. 10 (2021): 105009. http://dx.doi.org/10.1088/1361-6560/abee57.

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7

Odom, Robert W. "Secondary Ion Mass Spectrometry Imaging." Applied Spectroscopy Reviews 29, no. 1 (1994): 67–116. http://dx.doi.org/10.1080/05704929408000898.

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8

Leskiw, Brian D., Myung Hwa Kim, Gregory E. Hall, and Arthur G. Suits. "Reflectron velocity map ion imaging." Review of Scientific Instruments 76, no. 10 (2005): 104101. http://dx.doi.org/10.1063/1.2075167.

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9

P. Engler, R. L. Barbour, J. H. Gibson, M. S. Hazle, D. G. Cameron, and R. H. Duff. "Imaging With Spectroscopic Data." Advances in X-ray Analysis 31 (1987): 69–75. http://dx.doi.org/10.1154/s0376030800021856.

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Spectroscopic data from a var iety of analyt ical techniques such as x-ray diffraction (XRD), infrared (IR) and Raman spectroscopies, secondary ion mass spectrometry (SIMS) and energy dispersive X-ray analysis (EDX) can be obtained from small areas of samples (< 1 mm2) through the use of microscope sampling accessories. If provisions are made to scan or translate the sample, then a spectrum that is characteristic of each region of interest can be obtained. Alternatively, selective area detectors eliminate the requirement for scanning the sample. Extract ion of information about a specific e
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10

Hull, Robert, Derren Dunn, and Alan Kubis. "Nanoscale Tomographic Imaging using Focused Ion Beam Sputtering, Secondary Electron Imaging and Secondary Ion Mass Spectrometry." Microscopy and Microanalysis 7, S2 (2001): 934–35. http://dx.doi.org/10.1017/s1431927600030749.

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As the importance of nano-scaled structures in both science and engineering increases, techniques for reconstructing three-dimensional structural, crystallographic and chemical relationships become increasingly important. in this paper we described a technique which uses focused ion beam (FIB) sputtering to expose successive layers of a 3D sample, coupled with secondary electron imaging and secondary ion mass spectrometry of each sputtered surface. Computer interpolation of these different slice images then enables reconstruction of the 3D structure and chemistry of the sample. These technique
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11

Touboul, David, Fréderic Halgand, Alain Brunelle, et al. "Tissue Molecular Ion Imaging by Gold Cluster Ion Bombardment." Analytical Chemistry 76, no. 6 (2004): 1550–59. http://dx.doi.org/10.1021/ac035243z.

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12

Slodzian, Georges. "Ion microprobe imaging of biological samples." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (1992): 1600–1601. http://dx.doi.org/10.1017/s0424820100132637.

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Microanalysis of biological samples by using secondary ion emission is a challenging problem because it requires high lateral resolving power, high sensitivity and high selectivity simultaneously. In this paper, the limits and the possibilities of the method will be examined regardless of the sample preparation conditions that is from a simple instrumentalist's point of view.Any mass spectrometric method is destructive which means here that a given volume of the sample has to be sputtered to produce an adequate secondary ion signal. The size of this volume depends upon the atomic concentration
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13

Syed, Sarfaraz U. A. H., Simon Maher, Gert B. Eijkel, et al. "Direct Ion Imaging Approach for Investigation of Ion Dynamics in Multipole Ion Guides." Analytical Chemistry 87, no. 7 (2015): 3714–20. http://dx.doi.org/10.1021/ac5041764.

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14

Grimm, Casey C., R. T. Short, and Peter J. Todd. "A wide-angle secondary ion probe for organic ion imaging." Journal of the American Society for Mass Spectrometry 2, no. 5 (1991): 362–71. http://dx.doi.org/10.1016/1044-0305(91)85002-n.

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15

Carrascosa, Eduardo, Jennifer Meyer, and Roland Wester. "Imaging the dynamics of ion–molecule reactions." Chemical Society Reviews 46, no. 24 (2017): 7498–516. http://dx.doi.org/10.1039/c7cs00623c.

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A range of ion–molecule reactions have been studied in the last years using the crossed-beam ion imaging technique, from charge transfer and proton transfer to nucleophilic substitution and elimination.
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16

Li, Wen, Steven D. Chambreau, Sridhar A. Lahankar, and Arthur G. Suits. "Megapixel ion imaging with standard video." Review of Scientific Instruments 76, no. 6 (2005): 063106. http://dx.doi.org/10.1063/1.1921671.

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17

Mesa Sanchez, Daniela, Steve Creger, Veerupaksh Singla, Ruwan T. Kurulugama, John Fjeldsted, and Julia Laskin. "Ion Mobility-Mass Spectrometry Imaging Workflow." Journal of the American Society for Mass Spectrometry 31, no. 12 (2020): 2437–42. http://dx.doi.org/10.1021/jasms.0c00142.

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18

Yamamura, Hisao. "Imaging analyses of ion channel_molecule functions." Folia Pharmacologica Japonica 142, no. 2 (2013): 79–84. http://dx.doi.org/10.1254/fpj.142.79.

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19

Breese, M. B. H., P. J. C. King, J. Whitehurst, et al. "Dislocation imaging using transmission ion channeling." Journal of Applied Physics 73, no. 6 (1993): 2640–53. http://dx.doi.org/10.1063/1.353081.

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20

Burker, Alexander, Thomas Bergauer, Albert Hirtl, et al. "Imaging with Ion Beams at MedAustron." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 958 (April 2020): 162246. http://dx.doi.org/10.1016/j.nima.2019.05.087.

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21

Barroo, Cédric, and Thierry Visart de Bocarmé. "Imaging Graphene by Field Ion Microscopy." Microscopy and Microanalysis 22, S3 (2016): 1542–43. http://dx.doi.org/10.1017/s1431927616008552.

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22

Hepler, Peter K., and Dale A. Callaham. "Calcium ion imaging in plant cells." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 132–33. http://dx.doi.org/10.1017/s0424820100146503.

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Calcium ions (Ca) participate in many signal transduction processes, and for that reason it is important to determine where these ions are located within the living cell, and when and to what extent they change their local concentration. Of the different Ca-specific indicators, the fluorescent dyes, developed by Grynkiewicz et al. (1), have proved most efficacious, however, their use on plants has met with several problems (2). First, the dyes as acetoxy-methyl esters are often cleaved by extracellular esterases in the plant cell wall, and thus they do not enter the cell. Second, if the dye cr
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23

Wu, Huimeng, Sybren Sijbrandij, Shawn McVey, and John Notte. "Imaging Contrast with Multiple Ion Beams." Microscopy and Microanalysis 21, S3 (2015): 345–46. http://dx.doi.org/10.1017/s1431927615002524.

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24

Wu, Huimeng, Sybren Sijbrandij, Shawn McVey, and John Notte. "Imaging Contrast with Multiple Ion Beams." Microscopy and Microanalysis 21, S3 (2015): 701–2. http://dx.doi.org/10.1017/s1431927615004304.

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25

Norarat, R., V. Marjomäki, X. Chen, et al. "Ion-induced fluorescence imaging of endosomes." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 306 (July 2013): 113–16. http://dx.doi.org/10.1016/j.nimb.2012.12.052.

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26

Huang, Cunshun, Wen Li, Myung Hwa Kim, and Arthur G. Suits. "Two-color reduced-Doppler ion imaging." Journal of Chemical Physics 125, no. 12 (2006): 121101. http://dx.doi.org/10.1063/1.2353814.

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27

Huang, Cunshun, Sridhar A. Lahankar, Myung Hwa Kim, Bailin Zhang, and Arthur G. Suits. "Doppler-free/Doppler-sliced ion imaging." Physical Chemistry Chemical Physics 8, no. 40 (2006): 4652. http://dx.doi.org/10.1039/b612324d.

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28

Climen, B., B. Concina, M. A. Lebeault, F. Lépine, B. Baguenard, and C. Bordas. "Ion-imaging study of C60 fragmentation." Chemical Physics Letters 437, no. 1-3 (2007): 17–22. http://dx.doi.org/10.1016/j.cplett.2007.02.014.

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29

Forbes, Richard G. "Field-ion imaging old and new." Applied Surface Science 94-95 (March 1996): 1–16. http://dx.doi.org/10.1016/0169-4332(95)00516-1.

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30

Burnett, Paul, Janet K. Robertson, Jeffrey M. Palmer, Richard R. Ryan, Adrienne E. Dubin, and Robert A. Zivin. "Fluorescence Imaging of Electrically Stimulated Cells." Journal of Biomolecular Screening 8, no. 6 (2003): 660–67. http://dx.doi.org/10.1177/1087057103258546.

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Designing high-throughput screens for voltage-gated ion channels has been a tremendous challenge for the pharmaceutical industry because channel activity is dependent on the transmembrane voltage gradient, a stimulus unlike ligand binding to G-protein-coupled receptors or ligand-gated ion channels. To achieve an acceptable throughput, assays to screen for voltage-gated ion channel modulators that are employed today rely on pharmacological intervention to activate these channels. These interventions can introduce artifacts. Ideally, a high-throughput screen should not compromise physiological r
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31

McMahon, G., and L. J. Cabri. "SIMS direct ion imaging in the mineralogical sciences." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 698–99. http://dx.doi.org/10.1017/s0424820100165951.

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The use of secondary ion mass spectrometry (SIMS) has enjoyed increasing popularity in the mineralogical sciences owing to its high sensitivity to all elements in the periodic table with detection limits in the parts per million to parts per billion regime, coupled with the ability to display maps of elemental distribution at these detection levels with a spatial resolution of 1 μm. A description of the technique and its application to a wide variety of mineralogical problems has recently been reviewed.The drawback of SIMS is the rather complicated nature of quantification schemes necessitated
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32

Shu, Gang, Chen-Kuan Chou, Nathan Kurz, Matthew R. Dietrich, and Boris B. Blinov. "Efficient fluorescence collection and ion imaging with the “tack” ion trap." Journal of the Optical Society of America B 28, no. 12 (2011): 2865. http://dx.doi.org/10.1364/josab.28.002865.

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33

Rohrbach, Petra. "Imaging ion flux and ion homeostasis in blood stage malaria parasites." Biotechnology Journal 4, no. 6 (2009): 812–25. http://dx.doi.org/10.1002/biot.200900084.

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34

Brown, J. D., and W. Vandervorst. "Scanning ion imaging as a diagnostic tool for an ion microscope." Surface and Interface Analysis 7, no. 2 (1985): 74–78. http://dx.doi.org/10.1002/sia.740070204.

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35

Bell, David C. "Contrast Mechanisms and Image Formation in Helium Ion Microscopy." Microscopy and Microanalysis 15, no. 2 (2009): 147–53. http://dx.doi.org/10.1017/s1431927609090138.

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AbstractThe helium ion microscope is a unique imaging instrument. Based on an atomic level imaging system using the principle of field ion microscopy, the helium ion source has been shown to be incredibly stable and reliable, itself a remarkable engineering feat. Here we show that the image contrast is fundamentally different to other microscopes such as the scanning electron microscope (SEM), although showing many operational similarities due to the physical ion interaction mechanisms with the sample. Secondary electron images show enhanced surface contrast due the small surface interaction v
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36

Radici, Marco. "Electron Ion Collider: 3D-Imaging the Nucleon." EPJ Web of Conferences 182 (2018): 02062. http://dx.doi.org/10.1051/epjconf/201818202062.

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The Electron Ion Collider (EIC) is the project for a new US-based, high-energy, high-luminosity facility, capable of a versatile range of beam energies, polarizations, and ion species. Its primary goal is to precisely image quarks and gluons and their interactions inside hadrons, in order to investigate their confined dynamics and elucidate how visible matter is made at its most fundamental level. I will introduce the main physics questions addressed by such a facility, and give some more details on the topic of Transverse Momentum Dependent parton distributions (TMDs).
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37

Radici, Marco. "Electron Ion Collider: 3D-Imaging the Nucleon." EPJ Web of Conferences 182 (2018): 02103. http://dx.doi.org/10.1051/epjconf/201818202103.

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The Electron Ion Collider (EIC) is the project for a new US-based, high-energy, high-luminosity facility, capable of a versatile range of beam energies, polarizations, and ion species. Its primary goal is to precisely image quarks and gluons and their interactions inside hadrons, in order to investigate their confined dynamics and elucidate how visible matter is made at its most fundamental level. I will introduce the main physics questions addressed by such a facility, and give some more details on the topic of Transverse Momentum Dependent parton distributions (TMDs).
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38

Wirtz, Tom, Olivier De Castro, Jean-Nicolas Audinot, and Patrick Philipp. "Imaging and Analytics on the Helium Ion Microscope." Annual Review of Analytical Chemistry 12, no. 1 (2019): 523–43. http://dx.doi.org/10.1146/annurev-anchem-061318-115457.

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The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron–based imaging can be performed at resolutions down to 0.5 nm with high contrast, with high depth of field, and directly on insulating samples. Analytical methods include secondary electron hyperspectral imaging (SEHI), scanning transmission ion microscopy (ST
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39

Pachuta, Steven J. "Industrial applications of TOF-SIMS imaging." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 1040–41. http://dx.doi.org/10.1017/s0424820100167664.

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has in recent years become a useful tool for surface analysis in industrial laboratories. All elements and isotopes, as well as many molecular entities, can be detected by SIMS, with most of the signal coming from the outer 10 - 20 Å of the surface. The initial penetration of TOF-SIMS into industry was as an improvement over existing quadrupole instruments, with higher mass range, mass resolution, and sensitivity. The coupling of TOF-SIMS with high brightness liquid metal ion sources greatly expanded the applicability of the technique,
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40

Jackson, Shelley N., Damon Barbacci, Thomas Egan, Ernest K. Lewis, J. Albert Schultz, and Amina S. Woods. "MALDI-ion mobility mass spectrometry of lipids in negative ion mode." Anal. Methods 6, no. 14 (2014): 5001–7. http://dx.doi.org/10.1039/c4ay00320a.

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41

Chandra, Subhash. "Imaging transported and endogenous calcium independently at a subcellular resolution: ion microscopy imaging of calcium stable isotopes." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (1992): 1604–5. http://dx.doi.org/10.1017/s0424820100132650.

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Ion microscopy, based on secondary ion mass spectrometry (SIMS), is a unique isotopic imaging technique. The use of stable isotopes as tracers and their SIMS localization at a subcellular resolution has introduced a significant new approach for molecular localization and ion transport studies. A molecule of interest may be tagged with stable 2H, 13C, 15N, etc. and imaged with SIMS for its intracellular location. Stable isotopes of physiologically important elements such as calcium and magnesium provide excellent tracers for ion transport imaging studies with SIMS. in a recent study with 44Ca,
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42

Gebhardt, Christoph R., T. Peter Rakitzis, Peter C. Samartzis, Vlassis Ladopoulos, and Theofanis N. Kitsopoulos. "Slice imaging: A new approach to ion imaging and velocity mapping." Review of Scientific Instruments 72, no. 10 (2001): 3848–53. http://dx.doi.org/10.1063/1.1403010.

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43

McLean, John A., Whitney B. Ridenour, and Richard M. Caprioli. "Profiling and imaging of tissues by imaging ion mobility-mass spectrometry." Journal of Mass Spectrometry 42, no. 8 (2007): 1099–105. http://dx.doi.org/10.1002/jms.1254.

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44

Liu, Candace C., Erin F. McCaffrey, Noah F. Greenwald, et al. "Multiplexed Ion Beam Imaging: Insights into Pathobiology." Annual Review of Pathology: Mechanisms of Disease 17, no. 1 (2022): 403–23. http://dx.doi.org/10.1146/annurev-pathmechdis-030321-091459.

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Next-generation tools for multiplexed imaging have driven a new wave of innovation in understanding how single-cell function and tissue structure are interrelated. In previous work, we developed multiplexed ion beam imaging by time of flight, a highly multiplexed platform that uses secondary ion mass spectrometry to image dozens of antibodies tagged with metal reporters. As instrument throughput has increased, the breadth and depth of imaging data have increased as well. To extract meaningful information from these data, we have developed tools for cell identification, cell classification, and
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45

Joy, D. C., and J. R. Michael. "Modeling ion-solid interactions for imaging applications." MRS Bulletin 39, no. 4 (2014): 342–46. http://dx.doi.org/10.1557/mrs.2014.57.

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46

Ide, T., H. Sakamoto, and T. Yanagida. "Single molecule imaging of an ion-channel." Seibutsu Butsuri 40, supplement (2000): S205. http://dx.doi.org/10.2142/biophys.40.s205_4.

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47

Fletcher, John S. "Cellular imaging with secondary ion mass spectrometry." Analyst 134, no. 11 (2009): 2204. http://dx.doi.org/10.1039/b913575h.

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48

Breese, M. B. H., P. J. C. King, G. W. Grime, and P. R. Wilshaw. "Dislocation imaging using ion beam induced charge." Applied Physics Letters 62, no. 25 (1993): 3309–11. http://dx.doi.org/10.1063/1.109055.

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49

Samartzis, Peter C., Ioannis Sakellariou, Theodosia Gougousi, and Theofanis N. Kitsopoulos. "Photofragmentation study of Cl2 using ion imaging." Journal of Chemical Physics 107, no. 1 (1997): 43–48. http://dx.doi.org/10.1063/1.474389.

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50

Wester, Roland. "Velocity map imaging of ion–molecule reactions." Phys. Chem. Chem. Phys. 16, no. 2 (2014): 396–405. http://dx.doi.org/10.1039/c3cp53405g.

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