Relevant bibliographies by topics / Ionic current blockade

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Ionic current blockade'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Ionic current blockade.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Ionic current blockade"

1

Melnikov, Dmitriy V., Zachery K. Hulings, and Maria E. Gracheva. "Concentration Polarization, Surface Charge, and Ionic Current Blockade in Nanopores." Journal of Physical Chemistry C 124, no. 36 (August 11, 2020): 19802–8. http://dx.doi.org/10.1021/acs.jpcc.0c04829.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Tsutsui, Makusu, Kazumichi Yokota, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, and Tomoji Kawai. "Temporal Response of Ionic Current Blockade in Solid-State Nanopores." ACS Applied Materials & Interfaces 10, no. 40 (September 11, 2018): 34751–57. http://dx.doi.org/10.1021/acsami.8b11819.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tsutsui, Makusu, Yuhui He, Kazumichi Yokota, Akihide Arima, Sadato Hongo, Masateru Taniguchi, Takashi Washio, and Tomoji Kawai. "Particle Trajectory-Dependent Ionic Current Blockade in Low-Aspect-Ratio Pores." ACS Nano 10, no. 1 (December 7, 2015): 803–9. http://dx.doi.org/10.1021/acsnano.5b05906.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Tsutsui, Makusu, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, and Tomoji Kawai. "Silicon substrate effects on ionic current blockade in solid-state nanopores." Nanoscale 11, no. 10 (2019): 4190–97. http://dx.doi.org/10.1039/c8nr09042d.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Diaz Carral, Angel, Chandra Shekar Sarap, Ke Liu, Aleksandra Radenovic, and Maria Fyta. "2D MoS 2 nanopores: ionic current blockade height for clustering DNA events." 2D Materials 6, no. 4 (July 8, 2019): 045011. http://dx.doi.org/10.1088/2053-1583/ab2c38.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Song, S. C., J. A. Beatty, and C. J. Wilson. "The ionic mechanism of membrane potential oscillations and membrane resonance in striatal LTS interneurons." Journal of Neurophysiology 116, no. 4 (October 1, 2016): 1752–64. http://dx.doi.org/10.1152/jn.00511.2016.

Full text
Abstract:
Striatal low-threshold spiking (LTS) interneurons spontaneously transition to a depolarized, oscillating state similar to that seen after sodium channels are blocked. In the depolarized state, whether spontaneous or induced by sodium channel blockade, the neurons express a 3- to 7-Hz oscillation and membrane impedance resonance in the same frequency range. The membrane potential oscillation and membrane resonance are expressed in the same voltage range (greater than −40 mV). We identified and recorded from LTS interneurons in striatal slices from a mouse that expressed green fluorescent protein under the control of the neuropeptide Y promoter. The membrane potential oscillation depended on voltage-gated calcium channels. Antagonism of L-type calcium currents (CaV1) reduced the amplitude of the oscillation, whereas blockade of N-type calcium currents (CaV2.2) reduced the frequency. Both calcium sources activate a calcium-activated chloride current (CaCC), the blockade of which abolished the oscillation. The blocking of any of these three channels abolished the membrane resonance. Immunohistochemical staining indicated anoctamin 2 (ANO2), and not ANO1, as the CaCC source. Biophysical modeling showed that CaV1, CaV2.2, and ANO2 are sufficient to generate a membrane potential oscillation and membrane resonance, similar to that in LTS interneurons. LTS interneurons exhibit a membrane potential oscillation and membrane resonance that are both generated by CaV1 and CaV2.2 activating ANO2. They can spontaneously enter a state in which the membrane potential oscillation dominates the physiological properties of the neuron.
APA, Harvard, Vancouver, ISO, and other styles
7

Vogalis, F., R. J. Lang, R. A. Bywater, and G. S. Taylor. "Voltage-gated ionic currents in smooth muscle cells of guinea pig proximal colon." American Journal of Physiology-Cell Physiology 264, no. 3 (March 1, 1993): C527—C536. http://dx.doi.org/10.1152/ajpcell.1993.264.3.c527.

Full text
Abstract:
Smooth muscle cells enzymatically dispersed from the circular muscle layer of the guinea pig colon were examined for the expression of voltage-gated ionic currents using the whole cell patch-clamp technique. Three outward currents and one inward current were identified and characterized. The inward current, at physiological potentials, was generated by a voltage-gated Ca2+ conductance that was permeable to Ba2+ but blocked by Cd2+ (0.1 mM) or nifedipine (10 microM). The three outward currents were carried by K+, abolished when cells were internally perfused with Cs+, and distinguished by their sensitivity to known K(+)-channel blockers. A K+ current dependent on Ca2+ entry was activated at potentials positive to -40 mV and abolished by low concentrations (2-5 mM) of tetraethylammonium (TEA). A delayed rectifier-type K+ current activated slowly at potentials positive to -30 mV, showed little inactivation, and was abolished by higher concentrations (> 5 mM) of TEA. A rapidly activating and inactivating transient outward K+ current (IKto), activated at potentials positive to -60 mV, was abolished by low concentrations (3-5 mM) of 4-aminopyridine and was relatively insensitive to TEA (10-126 mM) blockade. The overlapping steady-state activation and inactivation curves of IKto revealed a "window current" phenomenon between -60 and -40 mV. The rapid activation of IKto at membrane potentials more negative than those for Ca2+ current suggests that IKto will influence cell excitability by delaying the upstroke of the action potential. The present data provide an ionic basis for the regenerative excitatory activity in the circular muscle layer of the guinea pig proximal colon.
APA, Harvard, Vancouver, ISO, and other styles
8

Wasserstrom, J. A., and J. J. Salata. "Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes." American Journal of Physiology-Heart and Circulatory Physiology 254, no. 6 (June 1, 1988): H1157—H1166. http://dx.doi.org/10.1152/ajpheart.1988.254.6.h1157.

Full text
Abstract:
We studied the effects of tetrodotoxin (TTX) and lidocaine on transmembrane action potentials and ionic currents in dog isolated ventricular myocytes. TTX (0.1-1 x 10(-5) M) and lidocaine (0.5-2 x 10(-5) M) decreased action potential duration, but only TTX decreased the maximum rate of depolarization (Vmax). Both TTX (1-2 x 10(-5) M) and lidocaine (2-5 x 10(-5) M) blocked a slowly inactivating toward current in the plateau voltage range. The voltage- and time-dependent characteristics of this current are virtually identical to those described in Purkinje fibers for the slowly inactivating inward Na+ current. In addition, TTX abolished the outward shift in net current at plateau potentials caused by lidocaine alone. Lidocaine had no detectable effect on the slow inward Ca2+ current and the inward K+ current rectifier, Ia. Our results indicate that 1) there is a slowly inactivating inward Na+ current in ventricular cells similar in time, voltage, and TTX sensitivity to that described in Purkinje fibers; 2) both TTX and lidocaine shorten ventricular action potentials by reducing this slowly inactivating Na+ current; 3) lidocaine has no additional actions on other ionic currents that contribute to its ability to abbreviate ventricular action potentials; and 4) although both agents shorten the action potential by the same mechanism, only TTX reduces Vmax. This last point suggests that TTX produces tonic block of Na+ current, whereas lidocaine may produce state-dependent Na+ channel block, namely, blockade of Na+ current only after Na+ channels have already been opened (inactivated-state block).
APA, Harvard, Vancouver, ISO, and other styles
9

Nishimura, Yoshihiro, Masaru Asahi, Koichi Saitoh, Hirofumi Kitagawa, Yuichi Kumazawa, Kunio Itoh, Min Lin, et al. "Ionic Mechanisms Underlying Burst Firing of Layer III Sensorimotor Cortical Neurons of the Cat: An In Vitro Slice Study." Journal of Neurophysiology 86, no. 2 (August 1, 2001): 771–81. http://dx.doi.org/10.1152/jn.2001.86.2.771.

Full text
Abstract:
We examined the ionic mechanisms underlying burst firing in layer III neurons from cat sensorimotor cortex by intracellular recording in a brain slice. Regular spiking was observed in 77.4% of 137 neurons in response to constant intracellular current pulses of 0.5- to 1-s duration. The rest of the neurons showed burst firing. An initial burst followed by regular-spike firing was seen in 71.0% of 31 bursting neurons. The rest of the bursting neurons ( n = 9) exhibited repetitive bursting. In the bursting neurons, spikes comprising the burst were triggered from the afterdepolarization (ADP) of the first spike of the burst. We examined the ionic mechanisms underlying the ADP by applying channel-blocking agents. The ADP was enhanced (rather than blocked) by Ca2+ channel blockade. This enhancement of the ADP by Ca2+channel blockade was apparent even after blockade of the afterhyperpolarization by apamin or intracellular Ca2+ chelation by EGTA. The firing rate of the regular-spiking cells was increased by apamin, intracellular EGTA or Ca2+ channel blockers. In 17.9% of the neurons examined ( n = 56), these agents switched the regular-spiking pattern into a bursting one. Burst firing could not be changed to regular spiking by these agents. Four neurons that responded with a single initial burst in control solution responded with repetitive bursting after application of these agents. We conclude that the main function of Ca2+ influx in layer III neurons is to activate Ca2+-dependent K+ conductance, which prevents or limits burst firing. At a time when spike amplitude was unchanged, the ADP was blocked and the burst firing changed to regular spiking by extracellularly applied tetrodotoxin (TTX) or intracellularly applied N-(2,6-dimethylphenylcarbamoylmethyl) triethyl ammonium bromide (QX314). We concluded that a TTX- and QX314-sensitive Na+ current underlies the ADP and therefore contributes to the burst firing of layer III neurons from the cat cortex.
APA, Harvard, Vancouver, ISO, and other styles
10

Bhattacharya, Swati, Jejoong Yoo, and Aleksei Aksimentiev. "Water Mediates Recognition of DNA Sequence via Ionic Current Blockade in a Biological Nanopore." ACS Nano 10, no. 4 (April 15, 2016): 4644–51. http://dx.doi.org/10.1021/acsnano.6b00940.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Ionic current blockade"

1

Holmes, Matthew R. "Integration of Micropore and Nanopore Features with Optofluidic Waveguides for Single Particle Sensing." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/3037.

Full text
Abstract:
This dissertation outlines the research and development of ground-breaking nanometer sized openings (nanopores) integrated with an on-chip optofluidic platform. This platform represents a significant advancement for single nanoparticle sensing. In this work specifically, the integrated optofluidic platform has been used to electrically and optically filter and detect single nanoparticles using ionic current blockade and fluorescence experiments. The correlation of electrical and optical signal has provided the highest sensitivity single nanoparticle measurements ever taken with integrated optofluidic platforms. The particular optofluidic platform used for this work is an antiresonant reflecting optical waveguide (ARROW). ARROW hollow and solid core waveguides are interference based waveguides that are designed to guide light in low index media such as liquids and gases. Because of this unique guiding property, ARROW hollow cores can be used to sense and analyze low concentrations of single particles. Additionally, because ARROW platforms are based upon standard silicon processing techniques and materials, they are miniature sized (~1 cm2), inexpensive, highly parallelizable, provide a high degree of design flexibility, and can be integrated with many different optical and electrical components and sources. Finally, because of the miniature, integrated nature of the ARROW platform, it has the potential to be incorporated into hand held devices that could provide quick, inexpensive, user-friendly diagnostics. The ARROW platform has been through many revisions in the past several years in an attempt to improve performance and functionality. Specifically, advanced fabrication techniques that have been used to decrease the production time, increase the yield, and improve the optical quality of ARROW platforms are discussed in the first part of this work. These advancements were all developed in order to facilitate the production of high quality integrated nanopores and ARROW platforms. The second part of this work then focuses on the actual integration of micrometer sized openings (micropores) and nanopores in the hollow waveguide section of ARROW platforms for filtering, detecting, and analyzing single nanoparticles. The successes and attempts at achieving these results are the basis of this dissertation of work.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Ionic current blockade"

1

Deamer, David W., Hugh Olsen, Mark A. Akeson, and John J. Kasianowicz. "Mechanism of Ionic Current Blockades during Polymer Transport through Pores of Nanometer Dimensions." In Structure and Dynamics of Confined Polymers, 165–75. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0401-5_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Ionic current blockade"

1

Li, Kun, Wei Si, Jingjie Sha, and Yunfei Chen. "Molecular Dynamics Study of DNA Translocation Through Graphene Nanopores With Controllable Speed." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50858.

Full text
Abstract:
All-atom steered molecular dynamics (SMD) simulations provide the means to study the single-stranded DNA (ssDNA) translocation through graphene nanopores at a controllable speed. The ssDNA is pulled by an elastic force similar to the manipulation by an AFM tip. At the same time, an electric field is applied across the reservoir along the direction of the pulling force, in order to hold the ssDNA strand taut and drive the ions in the solutions through the nanopore. By monitoring and analyzing the average ionic current blockage of poly(dA)10, poly(dC)10, poly(dG)10 and poly(dT)10, it is found that one can indeed discriminate the different DNA bases from each other by holding each nucleotide in the pore for sufficiently long time. It is obtained the average blocked ionic currents can be listed, in a increasing order, as IG<IA<IT, which is almost in agreement with the order of sizes of the four nucleotides (VG>VA>VT>VC), apart from C. The results indicate that physical occupancy of the nucleotide plays the major role in affecting average blocked ionic current when the DNA translocation speed is effectively slowed down. This work provides a clue for the further investigation to realize the discrimination of the four nucleotides by the method of actively controlling DNA molecule translocation speed through the nanopores.
APA, Harvard, Vancouver, ISO, and other styles
2

Xu, Dongyan, Yuejun Kang, Dongqing Li, Deyu Li, Manoj Sridhar, Anthony B. Hmelo, and Leonard C. Feldman. "Ultra-Sensitive Fluidic Sensors by Integrating Fluidic Circuits and MOSFETs." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-42518.

Full text
Abstract:
Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One important and promising class of nanofluidic devices detects single molecules by inserting a nanopore or nanochannel between two fluid cells and inducing an ionic current by applying an electric bias across the nanopore or nanochannel. When molecules are translocated through the nanopore/nanochannel, a modulation of the baseline ionic current can be observed. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size to be comparable to the molecules to be detected. Here we report on a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by up to 75 times. In this scheme, the device connects the gate of a MOSFET with a fluidic circuit and monitors the modulation of MOSFET’s drain current to detect particles. We demonstrate that amplification can be achieved from both the fluidic circuit and the MOSFET. For a 9.86 μm diameter polystyrene bead that occupies 0.7% of the total volume of the sensing channel, results show that the drain current of the MOSFET is blocked by 30–46%. We also demonstrate the capability of this device to distinguish particles with similar sizes but different surface charges as they translocate through the sensing channel. More interestingly, the experiments with CD4+ T lymphocyte cells show another modulation pattern: the MOSFET’s drain current is first enhanced and then blocked, which is not fully understood and needs further investigation. Although at this moment the device is based on microchannels and the particles detected are micron-size beads and cells, we expect that the same scheme can be applied to nanofluidic circuits for single molecule detection.
APA, Harvard, Vancouver, ISO, and other styles
3

Mulero, Rafael, Alejandro Moraga, and Min Jun Kim. "High Resolution Detection and Configuration of Bacteria Using Microscale Pores." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-41199.

Full text
Abstract:
A novel method for detecting and configuring bacteria using a micro-scale pore is presented. The method distinguishes between different species of bacteria by measuring the ionic current blockage (resistive pulse) as bacteria electrophoretically translocate the micro-pore. Both wild-type flagellated (HCB 33) and non-flagellated Escherichia coli (HCB 5), and Polystyrene microbeads were used in this study to demonstrate the efficacy of this method. High resolution electrical signal readout enabled discrimination of the orientation of both non-flagellated and peritrichously flagellated bacteria as they move through the solid-state pore.
APA, Harvard, Vancouver, ISO, and other styles
4

Kim, Min Jun, Meni Wanunu, Gautam Soni, and Amit Meller. "Nanopore Sensors for Ultra-Fast DNA Analysis." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-15571.

Full text
Abstract:
We have developed novel approaches for ultra-fast DNA analysis by measuring of an ionic current blockage and parallel optical readout of DNA translocation through single nanopores and nanopore arrays. Parallelism is achieved by the fabrication of high density solid-state arrays of single nanometer resolution pores and simultaneous optical readout of DNA translocation. Optical readout in arrays circumvents the direct electrical addressing of each pore. We will present new nanofabrication techniques to create nanoscale pores in 50 nm thick silicon nitride membrane using transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) and discuss our progress towards ultra-fast DNA sequencing.
APA, Harvard, Vancouver, ISO, and other styles
5

Mulero, Rafael, William R. Hesse, Liang Wu, and Min Jun Kim. "Probing Bacterial Flagellar Polymorphism in Various Fluidic Environments Using Solid-State Sub-Micropores." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66670.

Full text
Abstract:
A novel method for the detection of an assortment of environmental conditions in a microfluidic system using bacterial flagella and submicro-scale solid state pores is presented. Differences in various environmental conditions stimulate the polymorphic helix structure of Salmonella typhimurium flagella to transform to its lowest energetic conformation. By measuring the ionic current blockage (resistive pulse) as flagella electrophoretically translocate a submicro-scale pore, detection of the polymorphic state of flagella corresponding to the conditions of the environmental stimuli is possible. We test the viability of this method using purified depolymerized and repolymerized S. Typhimurium flagella and a high resolution electrical signal readout sub-micropore-based detection system.
APA, Harvard, Vancouver, ISO, and other styles
6

Yang, Haojie, Zaoqi Duan, Wei Si, Kun Li, and Yunfei Chen. "Influence of Solution pH on DNA Translocation Velocity Through Alumina Nanopores." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66403.

Full text
Abstract:
Nanopores, which are promising as single-molecule sensing devices with low cost and high throughput, have offered significant insights into the research fields of static and dynamic molecular activities, properties, or interactions. In particular, due to its inherent sensitivity, high throughput, amplification-free sample preparation, nanopore will be potentially used in DNA sequencing. Nanopore-based sequencing is based on Coulter Counters, by measuring the distinct current reductions from individual DNA bases with different sizes as they are translocating through a nanopore. The sub-molecular details of an individual molecule can be gathered via recording modulations in the ionic current when a molecule passes through the nanopore under a bias voltage applied across the pore by two Ag/AgCl electrodes. The current blockage and dwell time obtained when the dsDNA translocates through nanopore are accumulated into scatter plots. Ionic current trace recorded at 1000 mv as 48kbp dsDNA translocate through 20 nm thickness with 35 nm alumina nanopore. Here, we apply Schrödinger’s first-passage-time distribution formula to study the distribution of DNA translocation time through alumina nanopores. The first-passage-time distribution is solved with the production of Fokker-Plank equation. Two useful parameters yielded the experimental results are analyzed: the diffusion constant of DNA inside the nanopore and the drift velocity of DNA translocation. By changing the pH value from 5.2 to 10.8 of the electrolyte solution, we notice that the drift velocity of DNA translocation and the diffusion constant of DNA inside the nanopore are extremely close to almost as 34 nm/μs. By changing the pH value of the electrolyte solution, we find that the surface charge density of the wall and the charge of the DNA molecule can be turned, which will result in different DNA molecule capture behaviors. The capture rate is about 17 s−1; the DNA molecule translocates through nanopore when the solution pH is 10.8; and 20 s−1 as the solution pH is 5.2. Theoretical modelling has also been conducted to analyze the experimental results. Hopefully, these findings will shed light on the transport properties of DNA in nanopores, which are relevant to future nanopore applications.
APA, Harvard, Vancouver, ISO, and other styles
7

Vahabi, Meisam, Emad Mehdizadeh, Mansour Kabganian, and Farshad Barazandeh. "Identification of an IPMC Actuator Model Using Incorporating a Nonlinear With Linear Least Squares Method." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-24585.

Full text
Abstract:
Ionic polymer metal composite is a class of electro-active polymers that are becoming more significant as smart actuators due to their large bending deflection, mechanical flexibility, low excitation voltage, low density, and ease of fabrication process. These properties make IPMCs suitable for a variety of application fields such as robotics, aerospace, biomedicine etc. There are a lot of linear and nonlinear models which describe actuation properties of IPMC. These models’ parameters may be obtained by various identification methods in which only a very few are nonlinear. Besides, there has been no model that explains all the physical phenomena associated with this actuator. In this paper, a new identification method is presented which incorporates a nonlinear with linear least squares method. This method is implemented on a nonlinear model. This model in comprised of two steps; as a first step, nonlinear relationship between the absorbed current and the voltage applied and as a second step relationship between the absorbed current and the blocked force are determined. The first and second steps are identified using a nonlinear and linear least squares methods, respectively.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Ionic current blockade' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography