Relevant bibliographies by topics / Ionophoric activity

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Ionophoric activity'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Ionophoric activity"

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Kavanagh, Oisín, Robert Elmes, Finbarr O’Sullivan, John Farragher, Shane Robinson, and Gavin Walker. "Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores." Pharmaceutics 13, no. 12 (2021): 2032. http://dx.doi.org/10.3390/pharmaceutics13122032.

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The importance of zinc in biology has gained greater recognition in recent years due to its essential contributions to the function of many endogenous enzymes. Disruption of zinc homeostasis may be useful in treating pathological conditions, such as Alzheimer’s, and for antiviral purposes. Despite the growth of knowledge and increased interest in zinc, little is known about the structure and function of zinc ionophores. In this study we analyse the Cambridge Structural Database and solution complexation studies found in the literature to identify key functional groups which may confer zinc ion
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Krylova, Oxana O., and Peter Pohl. "Ionophoric Activity of Pluronic Block Copolymers†." Biochemistry 43, no. 12 (2004): 3696–703. http://dx.doi.org/10.1021/bi035768l.

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Hards, Kiel, Duncan G. G. McMillan, Lici A. Schurig-Briccio, et al. "Ionophoric effects of the antitubercular drug bedaquiline." Proceedings of the National Academy of Sciences 115, no. 28 (2018): 7326–31. http://dx.doi.org/10.1073/pnas.1803723115.

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Bedaquiline (BDQ), an inhibitor of the mycobacterial F1Fo-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacterial cell death through a phenomenon known as uncoupling. The biochemical basis underlying this, in BDQ, is unresolved and may represent a new pathway to the development of effective therapeutics. In this communication, we demonstrate that BDQ can inhibit ATP synthesis in Escherichia coli by functioning as a H+/K+ ionophore, caus
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Brown, James R. D., Inmaculada C. Pintre, and Simon J. Webb. "Fructose controlled ionophoric activity of a cholate–boronic acid." Org. Biomol. Chem. 12, no. 16 (2014): 2576–83. http://dx.doi.org/10.1039/c4ob00165f.

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Okada, Yukihiro, Yuji Sugitani, Yoshinori Kasai, and Jun Nishimura. "The Catalytic Activity of Ionophoric Calix[4]arene Analog." Bulletin of the Chemical Society of Japan 67, no. 2 (1994): 586–88. http://dx.doi.org/10.1246/bcsj.67.586.

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Khutorskii, V. E., I. E. Shchechkin, A. A. Kamenchuk, and V. P. Kukhar'. "Relation between hydration and ionophoric activity of leukotriene B4." Theoretical and Experimental Chemistry 24, no. 3 (1988): 346–50. http://dx.doi.org/10.1007/bf00534565.

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Chen, Wen-Hua, Vaclav Janout, Masaharu Kondo, et al. "A Fine Line Between Molecular Umbrella Transport and Ionophoric Activity." Bioconjugate Chemistry 20, no. 9 (2009): 1711–15. http://dx.doi.org/10.1021/bc900246u.

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Zimbone, Stefania, Anna M. Santoro, Diego La Mendola, et al. "The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells." International Journal of Molecular Sciences 21, no. 8 (2020): 2866. http://dx.doi.org/10.3390/ijms21082866.

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Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic diseases, copper homeostasis is altered. Although many details in the pathways involved are still unknown, some copper-specific ligands have been successfully used as therapeutic agents. Copper-binding peptides able to modulate angiogenesis represent a possible way to value new drugs. We previously reported that a fragment (VEGF73-101) of vascular endothelial growth factor (VEGF165), a potent angiogenic, induced an apoptotic effect on human
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Deng, Li-Qun, Yong-Ming Lu, Chun-Qiong Zhou, Jin-Xiang Chen, Bo Wang, and Wen-Hua Chen. "Synthesis and potent ionophoric activity of a squaramide-linked bis(choloyl) conjugate." Bioorganic & Medicinal Chemistry Letters 24, no. 13 (2014): 2859–62. http://dx.doi.org/10.1016/j.bmcl.2014.04.093.

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Vudmaska, Ihor, Yuriy Salyha, and Serhiy Sachko. "Ionophore antibiotics and hop cones as regulators of digestion and metabolism in ruminants." Studia Biologica 18, no. 1 (2024): 155–70. http://dx.doi.org/10.30970/sbi.1801.759.

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The general characteristics of ionophore antibiotics and the mechanisms of their antimicrobial action were analyzed. Two types of ionophore antibiotics are known: those that transport ions across the membrane, and those that form a channel in the cell membrane through which ions pass. Ionophore antibiotics used in animal husbandry belong to the former group (monensin, lasalocid, salinomycin, narasin). They are synthesized by bacteria of the Streptomyces genus. Bacterial cells and rumen fluid differ in ionic composition, which is regulated by active ion transport. As a result, the cytoplasm of
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Dissertations / Theses on the topic "Ionophoric activity"

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Licen, Sabina. "Artificial ion transporters: synthesis, characterization and ionophoric activity on membrane models." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3084.

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2007/2008<br>Nel corso di alcuni anni il nostro gruppo di ricerca, ispirandosi alla struttura dei composti naturali anfotericina B e squalamina, ha sintetizzato una serie di composti che incorporano gli elementi strutturali fondamentali di questi due ionofori naturali: un’unità idrofobica rigida, una catena idrofilica (modulo di conduzione) e uno o due gruppi terminali polari. L’attività di questi composti nel trasporto di ioni attraverso il doppio strato fosfolipidico è stata investigata utilizzando liposomi come modelli di membrana e metodologie basate sulla spettroscopia NMR e su tecniche
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Vialle, Émilie. "Réactivité des polyéthers ionophores et des coumarines : vers des systèmes moléculaires efficaces pour la santé animale." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00867741.

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L'objectif de cette thèse, réalisée en collaboration avec la société Mérial, concerne la santé animale et s'oriente vers la synthèse de molécules actives à visée préventive ou thérapeutique. Deux sujets distincts sont abordés. Dans un premier temps, le but recherché est la synthèse d'une série de molécules présentant une activité anti-coccidienne pour le traitement préventif des poulets. Quarante-trois composés originaux, issus d'une synthèse courte à deux ou trois étapes, ont été préparés par hémi-synthèse de la monensine. Quinze molécules ont été testées in vitro et trois d'entre elles montr
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Dabbagh, Bazarbachi Husam. "Dietary polyphenols display zinc ionophore activity and modulate zinc signaling in hepatocarcinoma cells." Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/292248.

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El zinc és el metall de transició més abundant després del ferro a totes les cèl·lules, i un micronutrient essencial, presentant diverses funcions en sistemes biològics. D'altra banda, els polifenols de la dieta són micronutrients bioactius que mostren nombrosos beneficis per a la salut, com ara activitat antitumoral i neuroprotectora. Anteriors treballs del nostre grup d'investigació han demostrat que els polifenols interaccionen amb cations de zinc i tenen la capacitat de modular l'expressió de diferents gens implicats en l'homeòstasi d'aquest. En aquest treball van ser usats els flavonoides
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Prudhomme, Michelle. "Hémisynthèses d'analogues de la calcimycine ou A 23187 : propriétés ionophores, activité antibiotique." 63-Aubière : Impr. U.E.R. Sci, 1985. http://catalogue.bnf.fr/ark:/12148/cb361102709.

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Lemaître, Christelle. "Purification et caractérisation de protéines hydrophobes extraites du mucus épidermique de carpe (cyprinus carpio). Relations entre activités ionophores et antibactériennes." Rouen, 1996. http://www.theses.fr/1996ROUES056.

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Le rôle de défense contre les microorganismes a déjà été démontré parmi les nombreuses fonctions du mucus épidermique du poisson. En effet, les sécrétions épidermiques de la carpe (cyprinus carpio) contiennent des composés dont l'activité est comparable à celle des peptides de défense, connus chez les bactéries, les insectes, les amphibiens et les mammifères, actifs par la formation de pores dans les membranes cellulaires. Le mucus épidermique possède lui aussi la faculté de générer des canaux ioniques dans des bicouches lipidiques planes et les substances responsables de cette activité ionoph
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Rochdi, Mohamed. "Nouveaux derives de la monensine a. Etude de leurs proprietes ionophores dans les erythrocytes. Activites biologiques." Clermont-Ferrand 2, 1993. http://www.theses.fr/1993CLF21377.

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La monensine est un antibiotique polyether carboxylique obtenu a partir d'une souche de streptomyces cinnamonensis; utilisee souvent dans l'industrie agro-alimentaire et en biochimie. Nous nous sommes proposes d'apporter des modifications structurales par voie chimique sur le cycle hemiacetalique. Une nouvelle monensine protegee en c25 et c26, portant une double liaison sur le cycle a a ete obtenue. La deuxieme partie de ce travail porte sur l'etude des mouvements ioniques induites par la monensine et ses derives dans la membrane des erythrocytes humains, pour k#+ et h#+ (potentiometrie) dans
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El, Hamel Chahrazed. "Etude structurale de la porine OprF de Pseudomonas fluorescens et rôle de la région C-terminale dans la modulation de son activité ionophore en fonction de la température de croissance. Extension à la bactérie psychrotrophe Chryseomonas luteola." Rouen, 1999. http://www.theses.fr/1999ROUES084.

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La bactérie psychrotrophe P. Fluorescens MF0 est plus sensible aux antibiotiques de type β-lactamines à une température de croissance de 8°C qu'à une température de 28°C. Cette différence est parfaitement corrélée avec les valeurs de conductance obtenues pour les porines majoritaires de la membrane externe OprF à 8°C et 28°C puisqu'elles sont respectivement de 80 pS et 250 pS dans du NaCl 1M. Pour expliquer ce phénomène, les OprFs 8°C et 28°C ont été purifiées et les études de spectrométrie de masse et de dichroïsme circulaire ne montrent pas de différence dans leur structure primaire. Des mes
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Books on the topic "Ionophoric activity"

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Columb, Malachy O. Local anaesthetic agents. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0017.

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Local anaesthetic agents cause a pharmacologically induced reversible neuropathy characterized by axonal conduction blockade. They act by blocking the sodium ionophore and exhibit membrane stabilizing activity by inhibiting initiation and propagation of action potentials. They are weak bases consisting of three components: a lipophilic aromatic ring, a link, and a hydrophilic amine. The chemical link classifies them as esters or amides. Local anaesthetics diffuse through the axolemma as unionized free-base and block the ionophore in the quaternary ammonium ionized form. The speed of onset of b
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Book chapters on the topic "Ionophoric activity"

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Antoszczak, Michał, Jacek Rutkowski, and Adam Huczyński. "Structure and Biological Activity of Polyether Ionophores and Their Semisynthetic Derivatives." In Bioactive Natural Products. Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527684403.ch6.

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"Antibacterial action of hop resin materials." In European brewery convention. Oxford University PressOxford, 1991. http://dx.doi.org/10.1093/oso/9780199632831.003.0022.

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Abstract The antibacterial properties of hop resins has been shown to result from their ability to act as ionophores (ion-carriers). The resins conduct protons (and other ions) across cell membranes of sensitive bacteria causing inhibition of nutrient transport. The implications of these findings for practical brewing are i) small changes in beer pH induce large changes in antibacterial activity, ii) alcohol, although possessing antibacterial activity, does not enhance the action of hop resins, iii) hop substances can be used as selective agents in microbiological tests if certain variables ar
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Selwyn, M. J. "Ionophoretic activity and biological effects of triorganotin compounds." In Chemistry and Technology of Silicon and Tin. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198555803.003.0021.

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Abstract The toxicity of triorganotin compounds is considered in relation to their hydrophobicity, inhibition of oxidative phosphorylation by blocking H --conduction through the F component of the mitochondrial ATPase, inhibition of other enzymes, and catalysis of C1- /OH- exchange across membranes.
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Ahmed, Amr, Amr Ghit, Asmaa Houjak, and Mahmoud Elkazzaz. "Role of Zinc and Zinc Ionophores in Brain Health and Depression Especially during the COVID-19 Pandemic." In Antidepressants - Recent Advances, Applications and Translational Models [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102923.

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Zinc is a trace metal ion that has a role in both physiological and pathological processes, making it one of the most common and necessary components involved in brain function. Besides, zinc is required for cell proliferation control in a variety of mechanisms, including hormonal regulation of cell division. Also, zinc serves as a biochemical signal to immune cells and transcription factors involved in the synthesis of inflammatory cytokines. On the other hand, zinc has a variety of crucial roles in neurogenesis and also acts as a neuromodulator on a wide range of membrane receptors, ion chan
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Conference papers on the topic "Ionophoric activity"

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Calegari, Maria José, Werner Peter Marcon, Beatriz Pereira Espadin, et al. "The use of essential oils as an alternative to performance-enhancing antibiotics in beef cattle: Literature review." In VI Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvimulti2024-058.

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Brazilian livestock farming stands out worldwide as a leader in the production and export of meat, driven by a significant herd of approximately 234.4 million head, according to IBGE data from 2023. The beef cattle production cycle comprises three distinct phases: breeding, rearing and finishing, each culminating in the production of weaned calves, lean steers and fat steers, respectively. This activity, predominantly based on pasture due to tropical climatic conditions, faces challenges such as pasture degradation and forage seasonality, requiring the use of technologies such as growth-promot
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De Caterina, WALL R., D. Giannessi, G. Lazzerini, A. Mazzone, A. Azzara, and F. Mosca. "5-LIPOOXYGENASE ACTIVITY IN THE HUMAN VESSEL WALL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643944.

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5-lipooxygenase products have been identified from a variety of cells and may play a role in the progression of atherosclerosis and in its clinical manifestations (spasm, thrombosis). We investigated whether human vascular fragments, freshly obtained at surgery, are able to produce leukotriene (LT) B4, a definite end product of 5-lipooxygenase, provided with biological activity. Fragments obtained from human saphenous veins (n=21) or aorta (fibrous plaques, n=15, atheromas, n=16) were incubated in buffer at 37°C with mechanical agitation sequentially in the absence (15 min) and in the presence
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Schleef, R. R., M. P. Bevilacqua, M. Sawdey, M. A. Gimbrone, and D. J. Loskutoff. "INTERLEUKIN 1 (IL-1) AND TUMOR NECROSIS FACTOR (TNF) ACTIVATION OF VASCULAR ENDOTHELIUM: EFFECTS ON PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) AND TISSUE-TYPE PLASMINOGEN ACTIVATOR (tPA)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642864.

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The regulation of the fibrinolytic system of cultured human umbilical vein endothelial cells (ECs) by two distinct monokines (IL-1 and TNF) was investigated. Conditioned media (CM) was collected from ECs cultured for 24 h in the presence of the monokines and analyzed in quantitative immunological assays for PAI-1 activity and tPA antigen. Both monokines induced a dose-dependent increase in extracellular PAI-1 activity, with a concomitant decrease in tPA antigen. Maximal effects were achieved with either 10 U/ml IL-1 or 200 U/ml of TNF, and resulted in a 4 fold increase in PAI-1 and a 50% decre
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verhallen, P. F. J., E. M. Bevers, P. Comfurius, W. M. A. Linkskens, and R. F. A. Zwaal. "CALPAIN-MEDIATED CYTOSKELETAL DEGRADATION CORRELATES WITH STIMULATION OF PLATELET PROCOAGULANT ACTIVITY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642821.

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We have shown earlier that the negatively charged phospholipid phosphatidylserine (PS), which becomes translocated from the inner surface to the outer surface of the plasma membrane upon platelet activation, is responsible for platelet procoagulant activity. Studies with erythrocytes have suggested a role for cytoskeletal proteins in the regulation of transmembrane asymmetry of PS. The possibility that platelet cytoskeletal proteins are involved in the loss of transmembrane asymmetry of PS, was explored by correlative investigations of both platelet prooagulant activity and activity of calpain
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Teitel, J. M., A. Shore, and J. McBarron. "REGULATION OF INTERLEUKIN-2 (IL-2) PRODUCTION BY ENDOTHELIAL CELL (EC) DERIVED SUBSTANCES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642865.

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We recently reported that vascular EC support the staphylococcal protein A (SPA)-induced production of IL-2 by T cells, and furthermore do so synergistically with monocytes. We have now assessed the contributions of EC membrane-associated and secreted factors to these functions. IL-2 was measured by either human tonsil blast of CTLL cell assay. Separation of EC from T cells by a permeable membrane (.45μ pore size) prevented IL-2 production. Consistent with this, supernatant from resting EC (ECs) was also unable to induce IL-2 generation. In addition, neither a crude EC plasma membrane preparat
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Miura, T., M. Inagaki, M. Taki, N. Saito, T. Meguro, and K. Yamada. "GRANULOCYTE ELASTASE RELEASE DURING BLOOD COAGULATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643166.

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Granulocyte elastase (ELP) has a high-potency fibrinolytic activity. Hence, there is a possibility that ELP acts as a thrombolytic enzyme like plasmin in thrombolysis. We investigated the release of ELP from granulocytes, especially during blood coagulation.The biological activity of ELP was measured using a synthetic substrate, Suc-Ala-Tyr-Leu-Val-pNA. The immunological activity assayed as an alpha-l-antitrypsin-ELP complex was measured using an anti-ELP antibody (Merck), because more than 90% of ELP in blood forms alpha-l-antitrypsin-ELP complexes.The ELP activity in granulocytes extracted b
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Labow, R. S., E. Meek, G. A. Adams, and G. Rock. "AGGREGATION RESPONSE OF PLATELETS DURING INHIBITION OF PHOSPHOLIPASE A2." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644542.

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Arachidonic acid (AA) is liberated from platelet membrane phospholipids during stimulation and promotes cellular aggregation through the synthesis of thromboxane A2. Two pathways; phospholipase A2 (PLA2) or phospholipase C (PLC) followed by the action of acylglycerolipases, are thought to be activated during platelet stimulation and supply the necessary AA. We have reported that mono (2-ethylhexyl)phthalate (MEHP), a physiological metabolite of the plasticizer di(2-ethylhexyl)-phthalate (DEHP), commonly used in a variety of medical devices and storage containers, inhibits PLA2, but not PLC in
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Purdon, A. D., and J. B. Smith. "ISOLATION OF A SOLUBLE PHOSPHOLIPASE A2 FROM HUMAN PLATELETS ACTIVE AGAINST 1-ACYL-2-ARACHIDONOYL GLYCEROPHOSPHOCHOLINE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644628.

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Previously, we have shown that 1-acyl-2-arachidonoyl glycero-phosphocholine (GPC) is the main source of arachidonic acid in thrombin-stimulated (5 U/ml) human platelets. Thus 1-acyl-2-3H-arachidonoyl GPC was dispersed in Tris buffer, 0.01 M, pH 7.5, 0.01 M CaCl2 for use a substrate for the assay of phospholipase A2 activity in human platelets. The released 3H-arachidonate(AA) was isolated by thin layer chromatography following Bligh and Dyer extraction of the enzyme-substrate incubate. Phospholipase A2 (PLA2) specific for this phospholipid was thought to be membrane bound and of low activity w
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Sakai, T., K. Okada, H. Bando, S. Ueshima, N. Tanaka, and O. Matsuo. "ANALYSIS OF THE SECRETION MECHANISM OF TISSUE-TYPE PLASMINOGEN ACTIVATOR IN A HUMAN MELANOMA CELL LINE (BOWES)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644397.

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The human melanoma cell line (Bowes) secretes tissue-type plasminogen activator (t-PA) into the culture medium. As reported previously, the secretion of t-PA was depressed and t-PA was accumulated in the intracellular compartment at alternative sodium and potassium ion concentrations and also in the presence of monensin, an ionophore for monovalent cations. In the present study, the secretion and intracellular distribution of t-PA were investigated by radioisotope labeling and fractionation of the cell organelles under normal and monensin-treated conditions. Cell homogenate was fractioneted by
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Ortega, M. P., C. Sunkel, and J. G. Priego. "INHIBITION OF HUMAN PLATELET FUNCTION BY PCA-4230." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643431.

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PCA-4230 (3-{2-(N-l,2-benzisothiazolyl-3(2H)one-1,1-dioxide) ethoxycarbonyl}-2,6-dimethyl-5-ethoxycarbonyl-4-methyl-l,4-dihy-dropyridine) is a new synthetic compound which has been selected after evaluation of .several series of molecules included in an ex tensive program of synthesis and biological screening.The purpose of this study was to investigate the In vUjiO effects of PCA-4230 on human platelet function.Platelet aggregation (PA) was measured, in platelet rich plasma (PRP) or washed platelets, according to Born’s technique. Release reaction (RR) was measured by the luminiscence method
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