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Journal articles on the topic 'Ionophoric activity'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Kavanagh, Oisín, Robert Elmes, Finbarr O’Sullivan, John Farragher, Shane Robinson, and Gavin Walker. "Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores." Pharmaceutics 13, no. 12 (2021): 2032. http://dx.doi.org/10.3390/pharmaceutics13122032.

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The importance of zinc in biology has gained greater recognition in recent years due to its essential contributions to the function of many endogenous enzymes. Disruption of zinc homeostasis may be useful in treating pathological conditions, such as Alzheimer’s, and for antiviral purposes. Despite the growth of knowledge and increased interest in zinc, little is known about the structure and function of zinc ionophores. In this study we analyse the Cambridge Structural Database and solution complexation studies found in the literature to identify key functional groups which may confer zinc ion

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2

Krylova, Oxana O., and Peter Pohl. "Ionophoric Activity of Pluronic Block Copolymers†." Biochemistry 43, no. 12 (2004): 3696–703. http://dx.doi.org/10.1021/bi035768l.

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3

Hards, Kiel, Duncan G. G. McMillan, Lici A. Schurig-Briccio, et al. "Ionophoric effects of the antitubercular drug bedaquiline." Proceedings of the National Academy of Sciences 115, no. 28 (2018): 7326–31. http://dx.doi.org/10.1073/pnas.1803723115.

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Bedaquiline (BDQ), an inhibitor of the mycobacterial F1Fo-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacterial cell death through a phenomenon known as uncoupling. The biochemical basis underlying this, in BDQ, is unresolved and may represent a new pathway to the development of effective therapeutics. In this communication, we demonstrate that BDQ can inhibit ATP synthesis in Escherichia coli by functioning as a H+/K+ ionophore, caus

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Brown, James R. D., Inmaculada C. Pintre, and Simon J. Webb. "Fructose controlled ionophoric activity of a cholate–boronic acid." Org. Biomol. Chem. 12, no. 16 (2014): 2576–83. http://dx.doi.org/10.1039/c4ob00165f.

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Okada, Yukihiro, Yuji Sugitani, Yoshinori Kasai, and Jun Nishimura. "The Catalytic Activity of Ionophoric Calix[4]arene Analog." Bulletin of the Chemical Society of Japan 67, no. 2 (1994): 586–88. http://dx.doi.org/10.1246/bcsj.67.586.

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6

Khutorskii, V. E., I. E. Shchechkin, A. A. Kamenchuk, and V. P. Kukhar'. "Relation between hydration and ionophoric activity of leukotriene B4." Theoretical and Experimental Chemistry 24, no. 3 (1988): 346–50. http://dx.doi.org/10.1007/bf00534565.

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Chen, Wen-Hua, Vaclav Janout, Masaharu Kondo, et al. "A Fine Line Between Molecular Umbrella Transport and Ionophoric Activity." Bioconjugate Chemistry 20, no. 9 (2009): 1711–15. http://dx.doi.org/10.1021/bc900246u.

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8

Zimbone, Stefania, Anna M. Santoro, Diego La Mendola, et al. "The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells." International Journal of Molecular Sciences 21, no. 8 (2020): 2866. http://dx.doi.org/10.3390/ijms21082866.

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Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic diseases, copper homeostasis is altered. Although many details in the pathways involved are still unknown, some copper-specific ligands have been successfully used as therapeutic agents. Copper-binding peptides able to modulate angiogenesis represent a possible way to value new drugs. We previously reported that a fragment (VEGF73-101) of vascular endothelial growth factor (VEGF165), a potent angiogenic, induced an apoptotic effect on human

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9

Deng, Li-Qun, Yong-Ming Lu, Chun-Qiong Zhou, Jin-Xiang Chen, Bo Wang, and Wen-Hua Chen. "Synthesis and potent ionophoric activity of a squaramide-linked bis(choloyl) conjugate." Bioorganic & Medicinal Chemistry Letters 24, no. 13 (2014): 2859–62. http://dx.doi.org/10.1016/j.bmcl.2014.04.093.

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10

Vudmaska, Ihor, Yuriy Salyha, and Serhiy Sachko. "Ionophore antibiotics and hop cones as regulators of digestion and metabolism in ruminants." Studia Biologica 18, no. 1 (2024): 155–70. http://dx.doi.org/10.30970/sbi.1801.759.

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The general characteristics of ionophore antibiotics and the mechanisms of their antimicrobial action were analyzed. Two types of ionophore antibiotics are known: those that transport ions across the membrane, and those that form a channel in the cell membrane through which ions pass. Ionophore antibiotics used in animal husbandry belong to the former group (monensin, lasalocid, salinomycin, narasin). They are synthesized by bacteria of the Streptomyces genus. Bacterial cells and rumen fluid differ in ionic composition, which is regulated by active ion transport. As a result, the cytoplasm of

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11

D., DASGUPTA, THANABAL V., and KRISHNAN V. "Cation Complexation and Conformational Changes of Crown Ether Complexes of Bovine Serum Albumin." Journal of Indian Chemical Society Vol. 63, Jan 1986 (1986): 118–22. https://doi.org/10.5281/zenodo.6255201.

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Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560 012 Macrocyclic polyethers, benzo-15-crown-5 and dibenzo-18-crown-6 have been coupled to bovine serum albumin (bsa) vsa diazolinkage in order to elucidate the changes in conformation of the protein upon (i) conjugate formation and (ii) addition of Na<sup>+</sup>, K<sup>+</sup> and Ca<sup>2+ </sup>to the crown ether moieties of the conjugate. Gel filtration studies of the coupled complex reveal the homogeneity and the presence of cross linkage in the conjugate of <em>cis</em> and trans dibenzo-18-crown-6.

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12

Sachko, S. R. "The effect of therapeutic feed additive on rumen fermentation in cows with ketosis." Animal Biology 25, no. 1 (2023): 39–45. http://dx.doi.org/10.15407/animbiol25.01.039.

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It is known that ionophoric antibiotics regulate ruminal fermentation, improve the utilization of feed protein, and prevent the occurrence of ketosis and steatosis in ruminants. Ionophoric antibiotics and β-acids of hops have a similar spectrum of biological activity, that is, they inhibit the vital activity of most gram-positive microorganisms of the rumen. Bacteria, like other living organisms, need vitamin E as an active antioxidant for cell membranes. The toxicity of tocopherol is very low, so adding it to the diet of ruminants in larger quantities can stimulate celluloselytic rumen bacter

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13

Dutseva, E. A., E. A. Kotova, and Yu N. Antonenko. "Ionophoric activity of truncated gramicidin A analogue in phospholipid bilayers and mitochondrial and erythrocyte membranes." Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology 2, no. 1 (2008): 55–61. http://dx.doi.org/10.1134/s1990747808010091.

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14

Duval, Delphine, Frank G. Riddell, Sylvie Rebuffat, Nicole Platzer, and Bernard Bodo. "Ionophoric activity of the antibiotic peptaibol trichorzin PA VI: a 23Na- and 35Cl-NMR study." Biochimica et Biophysica Acta (BBA) - Biomembranes 1372, no. 2 (1998): 370–78. http://dx.doi.org/10.1016/s0005-2736(98)00080-7.

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15

Kreiser, Topaz, Dor Zaguri, Shreya Sachdeva, et al. "Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions." Pharmaceuticals 15, no. 3 (2022): 377. http://dx.doi.org/10.3390/ph15030377.

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Controlling the infectivity of respiratory RNA viruses is critical, especially during the current SARS-CoV-2 pandemic. There is an unmet need for therapeutic agents that can reduce viral replication, preferably independent of the accumulation of viral mutations. Zinc ions have an apparent activity as modulators of intracellular viral RNA replication and thus, appear attractive in reducing viral RNA load and infectivity. However, the intracellular concentration of zinc is usually too low for achieving an optimal inhibitory effect. Various herbal polyphenols serve as excellent zinc ionophores wi

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16

Kim, Ryungsoon Song, Ivan Bihler, and Frank S. LaBella. "Calcium-translocating and cardiotonic properties of oxidation products of linoleic acid." Canadian Journal of Physiology and Pharmacology 63, no. 11 (1985): 1392–97. http://dx.doi.org/10.1139/y85-229.

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Calcium-translocating activity of linoleic acid and its lipoxygenase (linoleate: oxygen oxidoreductase; EC 1.13.11.12) metabolites or autoxidation products was determined in vitro by estimation of 45Ca transport from a bulk aqueous to a bulk organic phase. Fresh commercial linoleic acid, tested immediately after removal from a sealed vial, stimulated calcium translocation only at concentrations greater than 1 mM. In contrast, 45Ca translocation by linoleic acid exposed to air was detectable at 10 μM. Oxidation products of linoleic acid obtained either by incubation with lipoxygenase or by auto

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17

BATY, Daniel, Jeremy LAKEY, Franc PATTUS, and Claude LAZDUNSKI. "A 136-amino-acid-residue COOH-terminal fragment of colicin A is endowed with ionophoric activity." European Journal of Biochemistry 189, no. 2 (1990): 409–13. http://dx.doi.org/10.1111/j.1432-1033.1990.tb15503.x.

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18

Hammann, Peter, Gerhard Kretzschmar, Robert Klein, et al. "Secondary Metabolites by Chemical Screening 14. Transformation of Elaiophylin in subunits of Naturally Occurring Acid Ionophores: Synthesis, Anticoccidial Activity and Studies Concerning the Ionophoric Properties." HETEROCYCLES 32, no. 8 (1991): 1471. http://dx.doi.org/10.3987/com-91-5778.

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19

Pérez, Cirilo, Carmen G. Espínola, Concepción Foces-Foces, Pedro Núñez-Coello, Héctor Carrasco, and Julio D. Martín. "A Synthetic Hydroxy Acid That Shows Tubular-Shaped Structure in Solid-State and Ionophoric Activity in Phospholipid Bilayers." Organic Letters 2, no. 9 (2000): 1185–88. http://dx.doi.org/10.1021/ol005534j.

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20

Chérier, Dimitri, Delphine Patin, Didier Blanot, Thierry Touzé, and Hélène Barreteau. "The Biology of Colicin M and Its Orthologs." Antibiotics 10, no. 9 (2021): 1109. http://dx.doi.org/10.3390/antibiotics10091109.

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The misuse of antibiotics during the last decades led to the emergence of multidrug resistant pathogenic bacteria. This phenomenon constitutes a major public health issue. Consequently, the discovery of new antibacterials in the short term is crucial. Colicins, due to their antibacterial properties, thus constitute good candidates. These toxin proteins, produced by E. coli to kill enteric relative competitors, exhibit cytotoxicity through ionophoric activity or essential macromolecule degradation. Among the 25 colicin types known to date, colicin M (ColM) is the only one colicin interfering wi

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21

Izzo, Irene, Nakia Maulucci, Cristina Martone, et al. "On the importance of the pore inner cavity for the ionophoric activity of 1,3-alternate calix[4]arene/steroid conjugates." Tetrahedron 62, no. 23 (2006): 5385–91. http://dx.doi.org/10.1016/j.tet.2006.04.028.

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22

Perez, Cirilo, Carmen G. Espinola, Concepcion Foces-Foces, Pedro Nunez-Coello, Hector Carrasco, and Julio D. Martin. "ChemInform Abstract: A Synthetic Hydroxy Acid that Shows Tubular-Shaped Structure in Solid-State and Ionophoric Activity in Phospholipid Bilayers." ChemInform 31, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.200034156.

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23

Tempelaars, Marcel H., Susana Rodrigues, and Tjakko Abee. "Comparative Analysis of Antimicrobial Activities of Valinomycin and Cereulide, the Bacillus cereus Emetic Toxin." Applied and Environmental Microbiology 77, no. 8 (2011): 2755–62. http://dx.doi.org/10.1128/aem.02671-10.

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ABSTRACTCereulide and valinomycin are highly similar cyclic dodecadepsipeptides with potassium ionophoric properties. Cereulide, produced by members of theBacillus cereusgroup, is known mostly as emetic toxin, and no ecological function has been assigned. A comparative analysis of the antimicrobial activity of valinomycin produced byStreptomycesspp. and cereulide was performed at a pH range of pH 5.5 to pH 9.5, under anaerobic and aerobic conditions. Both compounds display pH-dependent activity against selected Gram-positive bacteria, includingStaphylococcus aureus,Listeria innocua,Listeria mo

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24

Macrì, Roberta, Vincenzo Musolino, Micaela Gliozzi, et al. "Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects." Molecules 25, no. 23 (2020): 5768. http://dx.doi.org/10.3390/molecules25235768.

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The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will fo

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Isobe, Minoru, Arthit Makarasen, and Toshio Nishikawa. "Synthesis of Four Lysine-Linked Cereulide Analogues Showing Ionophoric Activity Towards Potassium Cations as Lead Compounds for Emetic Toxin-Detection by Immunoassays." Synthesis 2009, no. 13 (2009): 2184–204. http://dx.doi.org/10.1055/s-0029-1216837.

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26

Ivanova, L., S. Uhlig, G. Eriksen, and L. Johannessen. "Enniatin B1 is a substrate of intestinal P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein." World Mycotoxin Journal 3, no. 3 (2010): 271–81. http://dx.doi.org/10.3920/wmj2010.1225.

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Enniatins are cyclic hexadepsipeptides produced by various fungi, known to have ionophoric, antibiotic and insecticidal activity. The aim of the present study was to evaluate the intestinal absorption characteristics of enniatin B1 (ENN-B1). Using the human intestinal Caco-2 cell line, we found that the permeability of ENN-B1 in the basolateral to apical direction was 6.7× higher as compared to the permeability in the opposite direction, indicating involvement of apically located transporters. Transport of ENN-B1 in the apical to basolateral direction was increased significantly upon treatment

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27

Martínez, Alberto, Mai Zahran, Miguel Gomez, et al. "Ionophoric polyphenols are permeable to the blood–brain barrier, interact with human serum albumin and Calf Thymus DNA, and inhibit AChE enzymatic activity." Medicinal Chemistry Research 29, no. 11 (2020): 1956–75. http://dx.doi.org/10.1007/s00044-020-02615-3.

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28

LUQUE-ORTEGA, J. Román, José M. SAUGAR, Cristina CHIVA, David ANDREU, and Luis RIVAS. "Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP." Biochemical Journal 375, no. 1 (2003): 221–30. http://dx.doi.org/10.1042/bj20030544.

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Leishmanicidal drugs interacting stoichiometrically with parasite plasma membrane lipids, thus promoting permeability, have raised significant expectations for Leishmania chemotherapy due to their nil or very low induction of resistance. Inherent in this process is a decrease in intracellular ATP, either wasted by ionic pumps to restore membrane potential or directly leaked through larger membrane lesions caused by the drug. We have adapted a luminescence method for fast automated real-time monitoring of this process, using Leishmania donovani promastigotes transfected with a cytoplasmic lucif

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Gumila, C., M. L. Ancelin, A. M. Delort, G. Jeminet, and H. J. Vial. "Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds." Antimicrobial Agents and Chemotherapy 41, no. 3 (1997): 523–29. http://dx.doi.org/10.1128/aac.41.3.523.

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Large-scale in vitro screening of different types of ionophores previously pinpointed nine compounds that were very active and selective in vitro against Plasmodium falciparum; their in vitro and in vivo antimalarial effects were further studied. Addition of the ionophores to synchronized P. falciparum suspensions revealed that all P. falciparum stages were sensitive to the drugs. However, the schizont stages were three- to ninefold more sensitive, and 12 h was required for complete parasite clearance. Pretreatment of healthy erythrocytes with toxic doses of ionophores for 24 to 48 h showed th

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Buko, V., E. Belonovskaya, T. Kavalenia, et al. "Anthocyanin-Rich Extract of Red Cabbage Attenuates Advanced Alcohol Hepatotoxicity in Rats in Association with Mitochondrial Activity Modulation." European Pharmaceutical Journal 69, no. 2 (2022): 5–16. http://dx.doi.org/10.2478/afpuc-2022-0014.

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Abstract Aim The liver is the main target for alcohol-induced injury. The aims of this work were to carry out further research into the mechanisms of liver damage induced by long-term administration of high-dose ethanol to rats and to evaluate the hepatoprotective potential of red cabbage (Brassica oleracea var. capitata f. rubra) anthocyanins (RCE). Material/Methods Male albino Wistar rats were divided into four groups. Group 1 was the control. Groups 2 through 4 received ethanol (4 g/kg body weight, 8 weeks). Group 3 received 11 mg RCE/kg and Group 4 received 22 mg RCE/kg. Dry lyophilised RC

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Schmeltzer, Alexandra J., Joel M. Harris, and Henry S. White. "(Invited) Single-Molecule Electrical Currents Associated with Valinomycin Transport of K⁺." ECS Meeting Abstracts MA2023-01, no. 44 (2023): 2429. http://dx.doi.org/10.1149/ma2023-01442429mtgabs.

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A quantitative description of ionophore-mediated ion transport is important in understanding ionophore activity in biological systems and developing new ionophore applications. We present the direct measurement of the electrical current resulting from K+ transport mediated by individual valinomycin (val) ionophores. Step fluctuations in current measured across a 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) bilayer suspended over a ~400 nm radius glass nanopore result from dynamic partitioning of val between the bilayer and torus region, effectively increasing or decreasing the total num

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OHKUMA, Shoji, Tomohiko SATO, Masayuki OKAMOTO, et al. "Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl− symport." Biochemical Journal 334, no. 3 (1998): 731–41. http://dx.doi.org/10.1042/bj3340731.

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We reported previously [Kataoka, Muroi, Ohkuma, Waritani, Magae, Takatsuki, Kondo, Yamasaki and Nagai (1995) FEBS Lett. 359, 53–59] that prodigiosin 25-C (one of the red pigments of the prodigiosin group produced by micro-organisms like Streptomycesand Serratia) uncoupled vacuolar H+-ATPase, inhibited vacuolar acidification and affected glycoprotein processing. In the present study we show that prodigiosin, metacycloprodigiosin and prodigiosin 25-C, all raise intralysosomal pH through inhibition of lysosomal acidification driven by vacuolar-type (V-)ATPase without inhibiting ATP hydrolysis in

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Fredericks, Lance R., Mark D. Lee, Angela M. Crabtree, et al. "The Species-Specific Acquisition and Diversification of a K1-like Family of Killer Toxins in Budding Yeasts of the Saccharomycotina." PLOS Genetics 17, no. 2 (2021): e1009341. http://dx.doi.org/10.1371/journal.pgen.1009341.

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Killer toxins are extracellular antifungal proteins that are produced by a wide variety of fungi, including Saccharomyces yeasts. Although many Saccharomyces killer toxins have been previously identified, their evolutionary origins remain uncertain given that many of these genes have been mobilized by double-stranded RNA (dsRNA) viruses. A survey of yeasts from the Saccharomyces genus has identified a novel killer toxin with a unique spectrum of activity produced by Saccharomyces paradoxus. The expression of this killer toxin is associated with the presence of a dsRNA totivirus and a satellite

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Gumila, C., M. L. Ancelin, G. Jeminet, A. M. Delort, G. Miquel, and H. J. Vial. "Differential in vitro activities of ionophore compounds against Plasmodium falciparum and mammalian cells." Antimicrobial Agents and Chemotherapy 40, no. 3 (1996): 602–8. http://dx.doi.org/10.1128/aac.40.3.602.

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Twenty-two ionophore compounds were screened for their antimalarial activities. They consisted of true ionophores (mobile carriers) and channel-forming quasi-ionophores with different ionic specificities. Eleven of the compounds were found to be extremely efficient inhibitors of Plasmodium falciparum growth in vitro, with 50% inhibitory concentrations of less than 10 ng/ml. Gramicidin D was the most active compound tested, with 50% inhibitory concentration of 0.035 ng/ml. Compounds with identical ionic specificities generally had similar levels of antimalarial activity, and ionophores specific

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35

Ivanova, L., C. K. Fæste, E. Van Pamel, E. Daeseleire, A. Callebaut, and S. Uhlig. "Presence of enniatin B and its hepatic metabolites in plasma and liver samples from broilers and eggs from laying hens." World Mycotoxin Journal 7, no. 2 (2014): 167–75. http://dx.doi.org/10.3920/wmj2013.1609.

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Enniatins, a large group of cyclodepsipeptides, are widely distributed contaminants of different crops intended for human and animal consumption. Enniatin B is one of the principal analogues in species of the genus Fusarium, known to have ionophoric, antibiotic, and insecticidal activity. Regardless of considerable cytotoxic effects observed in vitro, enniatins have been characterised as compounds with low acute toxicity in vivo. The biotransformation of enniatin B has previously been elucidated in liver microsomes, and 12 different metabolites (M1 to M12) have been reported. In order to provi

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Rasimus, Stiina, Raimo Mikkola, Maria A. Andersson, et al. "Psychrotolerant Paenibacillus tundrae Isolates from Barley Grains Produce New Cereulide-Like Depsipeptides (Paenilide and Homopaenilide) That Are Highly Toxic to Mammalian Cells." Applied and Environmental Microbiology 78, no. 10 (2012): 3732–43. http://dx.doi.org/10.1128/aem.00049-12.

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ABSTRACTPaenilide is a novel, heat-stable peptide toxin fromPaenibacillus tundrae, which colonizes barley.P. tundraeproduced 20 to 50 ng of the toxin mg−1of cells (wet weight) throughout a range of growth temperatures from +5°C to +28°C. Paenilide consisted of two substances of 1,152 Da and 1,166 Da, with masses and tandem mass spectra identical to those of cereulide and a cereulide homolog, respectively, produced byBacillus cereusNS-58. The two components of paenilide were separated from those of cereulide by high-performance liquid chromatography (HPLC), showing a structural difference sugge

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Castagnoli, Emmanuelle, Johanna Salo, Matti Toivonen, et al. "An Evaluation of Boar Spermatozoa as a Biosensor for the Detection of Sublethal and Lethal Toxicity." Toxins 10, no. 11 (2018): 463. http://dx.doi.org/10.3390/toxins10110463.

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A novel, objective, and rapid computed motility inhibition (CMI) assay was developed to identify and assess sublethal injury in toxin-exposed boar spermatozoa and compared with a subjective visual motility inhibition (VMI) assay. The CMI values were calculated from digital micrographic videos using a custom MATLAB® script by contrasting the motility index values of each experiment with those of the background and control experiments. Following a comparison of the CMI and VMI assays results, it was determined that their agreement depended on the shape of the dose-response curve. Toxins that exh

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Isakov, N., and A. Altman. "Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes." Journal of Immunology 135, no. 6 (1985): 3674–80. http://dx.doi.org/10.4049/jimmunol.135.6.3674.

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Abstract Antigen binding to its specific receptor on T cells initiates a series of intracellular events that result in cell differentiation, activation, and clonal expansion. However, the mechanism by which these antigen-occupied receptors induce the transmembrane signal transduction needs clarification. Because this mechanism appears to involve an increase in intracellular free Ca2+ concentration and activation of protein kinase C (PKC), we tested the effect of Ca2+ ionophores and PKC activators on alloantigen-specific primary mixed leukocyte culture cells. Both calcium ionophores, A23187 and

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TIEDTKE, A., L. RASMUSSEN, J. FLORIN-CHRISTENSEN, and M. FLORIN-CHRISTENSEN. "Release of lysosomal enzymes in Tetrahymena: a Ca2+-dependent secretory process." Journal of Cell Science 90, no. 1 (1988): 167–71. http://dx.doi.org/10.1242/jcs.90.1.167.

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The ciliate Tetrahymena thermophila releases lysosomal enzymes into nutrient and starvation media. We show here that this process occurs selectively, i.e. without leakage of cytoplasmic components, as indicated by lack of release of isocitrate dehydrogenase, a cytosolic enzyme with high activity in Tetrahymena. The role of intracellular Ca2+ in the process was also investigated. The Ca2+ ionophore A23187 has strong stimulatory effects on this release. Ionophore stimulation is maximal in the presence of extracellular Ca2+ but can occur also in its absence. Quin 2 fluorescence measurements indic

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Stefańska, Joanna, Karolina Stępień, Adam Huczyński, and Stefan Tyski. "Activity of Natural Polyether Ionophores: Monensin and Salinomycin against Clinical Staphylococcus epidermidis Strains." Polish Journal of Microbiology 64, no. 3 (2015): 273–78. http://dx.doi.org/10.5604/01.3001.0009.2122.

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Staphylococcus epidermidis, a coagulase-negative Staphylococcus, is the most important pathogen responsible for chronic nosocomial infections. These bacteria produce extracellular slime and form biofilms on various biotic and abiotic surfaces. Bacterial biofilms are very resistant to standard antimicrobial therapy and difficult to eradicate, so it is important to search for new more effective anti-biofilm agents, for example in the group of natural substances. The aim of the study was to examine the activity of two ionophores-salinomycin and monensin against clinical S. epidermidis strains, us

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Franklin, R. A., A. Tordai, B. Mazer, N. Terada, J. J. Lucas, and E. W. Gelfand. "Activation of MAP2-kinase in B lymphocytes by calcium ionophores." Journal of Immunology 153, no. 11 (1994): 4890–98. http://dx.doi.org/10.4049/jimmunol.153.11.4890.

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Abstract The role of increases in intracellular calcium levels on tyrosine phosphorylation in human B lymphocytes was studied. Stimulation of normal, resting B lymphocytes or B lymphoblastoid cells with the calcium ionophores ionomycin or A23187 induced the tyrosine phosphorylation and the enzymatic activation of microtubule-associated protein-2 kinase (MAP2-K). Treatment of these cells with PMA induced tyrosine phosphorylation of a protein with the identical mobility, as well as the enzymatic activation of MAP2-K. Stimulation of these cells with ionomycin also resulted in increased ribosomal

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Yu, Haijun, Yunfeng Zhou, Stuart E. Lind, and Wei-Qun Ding. "Clioquinol targets zinc to lysosomes in human cancer cells." Biochemical Journal 417, no. 1 (2008): 133–39. http://dx.doi.org/10.1042/bj20081421.

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We have previously demonstrated that clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) acts as a zinc ionophore and induces apoptosis of human cancer cells; however, the mechanisms of clioquinol/zinc-induced apoptotic cell death remain to be elucidated further. Using fluorescence-labelled probes, the present study has examined intracellular zinc distribution after clioquinol treatment in human cancer cells in order to identify cellular targets for zinc ionophores. DU 145, a human prostate cancer line, was chosen as a model system for the present study, and results were confirmed in other human c

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Wang, Hao, Ning Liu, Lijun Xi, Xiaoying Rong, Jisheng Ruan, and Ying Huang. "Genetic Screening Strategy for Rapid Access to Polyether Ionophore Producers and Products in Actinomycetes." Applied and Environmental Microbiology 77, no. 10 (2011): 3433–42. http://dx.doi.org/10.1128/aem.02915-10.

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ABSTRACTPolyether ionophores are a unique class of polyketides with broad-spectrum activity and outstanding potency for the control of drug-resistant bacteria and parasites, and they are produced exclusively by actinomycetes. A special epoxidase gene encoding a critical tailoring enzyme involved in the biosynthesis of these compounds has been found in all five of the complete gene clusters of polyether ionophores published so far. To detect potential producer strains of these antibiotics, a pair of degenerate primers was designed according to the conserved regions of the five known polyether e

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Graham, Rebecca E., Richard J. R. Elliott, Alison F. Munro, and Neil O. Carragher. "A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death." PLOS ONE 18, no. 12 (2023): e0294297. http://dx.doi.org/10.1371/journal.pone.0294297.

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A new form of cell death has recently been proposed involving copper-induced cell death, termed cuproptosis. This new form of cell death has been widely studied in relation to a novel class of copper ionophores, including elesclomol and disulfiram. However, the exact mechanism leading to cell death remains contentious. The oldest and most widely accepted biological mechanism is that the accumulated intracellular copper leads to excessive build-up of reactive oxygen species and that this is what ultimately leads to cell death. Most of this evidence is largely based on studies using N-acetylcyst

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Park, Man Ki, Jeong Hill Park, Jung Hwan Cho, Jun Kyu Park, Yong Nam Han, and Byung Hoon Han. "Ionophore activity of frangufoline." Archives of Pharmacal Research 14, no. 2 (1991): 103–4. http://dx.doi.org/10.1007/bf02892011.

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Wu, Hao, Jingdan Liang, Lixia Gou, et al. "Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882." Applied and Environmental Microbiology 84, no. 12 (2018): e00587-18. http://dx.doi.org/10.1128/aem.00587-18.

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ABSTRACT Type II thioesterases typically function as editing enzymes, removing acyl groups that have been misconjugated to acyl carrier proteins during polyketide secondary metabolite biosynthesis as a consequence of biosynthetic errors. Streptomyces chartreusis NRRL 3882 produces the pyrrole polyether ionophoric antibiotic, and we have identified the presence of a putative type II thioesterase-like sequence, calG, within the biosynthetic gene cluster involved in the antibiotic's synthesis. However, targeted gene mutagenesis experiments in which calG was inactivated in the organism did not lea

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Behr, Jürgen, and Rudi F. Vogel. "Mechanisms of Hop Inhibition Include the Transmembrane Redox Reaction." Applied and Environmental Microbiology 76, no. 1 (2009): 142–49. http://dx.doi.org/10.1128/aem.01693-09.

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ABSTRACT In this work, a novel mechanistic model of hop inhibition beyond the proton ionophore action toward (beer spoiling) bacteria was developed. Investigations were performed with model systems using cyclic voltammetry for the determination of redox processes/conditions in connection with growth challenges with hop-sensitive and -resistant Lactobacillus brevis strains in the presence of oxidants. Cyclic voltammetry identified a transmembrane redox reaction of hop compounds at low pH (common in beer) and in the presence of manganese (present in millimolar levels in lactic acid bacteria). Th

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Ishida, Y., and T. M. Chused. "Heterogeneity of lymphocyte calcium metabolism is caused by T cell-specific calcium-sensitive potassium channel and sensitivity of the calcium ATPase pump to membrane potential." Journal of Experimental Medicine 168, no. 3 (1988): 839–52. http://dx.doi.org/10.1084/jem.168.3.839.

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Calcium management differs in T and B lymphocytes. [Ca2+]i elevation in response to calcium ionophores is up to 10 times greater in T cells than B cells. There is no difference between them in ionophore uptake. T cells, but not B cells, possess a calcium-sensitive potassium channel which produces membrane hyperpolarization at [Ca2+]i above 200 nM. This alters T cell density providing a rapid and easy method of cell separation. In contrast, B cells depolarize when [Ca2+]i is increased. Isolated B cell membrane vesicle ATP-dependent calcium pump activity is higher than T cell vesicles. Membrane

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THABET, AHMED, JOHANNES SCHMIDT, SVEN BAUMANN, et al. "Resistance towards monensin is proposed to be acquired in a Toxoplasma gondii model by reduced invasion and egress activities, in addition to increased intracellular replication." Parasitology 145, no. 3 (2017): 313–25. http://dx.doi.org/10.1017/s0031182017001512.

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SUMMARYMonensin (Mon) is an anticoccidial polyether ionophore widely used to control coccidiosis. The extensive use of polyether ionophores on poultry farms resulted in widespread resistance, but the underlying resistance mechanisms are unknown in detail. For analysing the mode of action by which resistance against polyether ionophores is obtained, we induced in vitro Mon resistance in Toxoplasma gondii-RH strain (MonR-RH) and compared it with the sensitive parental strain (Sen-RH). The proteome assessment of MonR-RH and Sen-RH strains was obtained after isotopic labelling using stable isotope

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Glumac, Nada, Milan Momčilović, Iztok Kramberger, et al. "Potentiometric Surfactant Sensor with a Pt-Doped Acid-Activated Multi-Walled Carbon Nanotube-Based Ionophore Nanocomposite." Sensors 24, no. 8 (2024): 2388. http://dx.doi.org/10.3390/s24082388.

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Two new surfactant sensors were developed by synthesizing Pt-doped acid-activated multi-walled carbon nanotubes (Pt@MWCNTs). Two different ionophores using Pt@MWCNTs, a new plasticizer, and (a) cationic surfactant 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium-DHBI (Pt@MWCNT-DHBI ionophore) and (b) anionic surfactant dodecylbenzenesulfonate-DBS (Pt@MWCNT-DBS ionophore) composites were successfully synthesized and characterized. Both surfactant sensors showed a response to anionic surfactants (dodecylsulfate (SDS) and DBS) and cationic surfactants (cetylpyridinium chloride (CPC) and hexadecyltrimeth

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