Dissertations / Theses: 'IPDR'

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Chaudry, Kashif, and Elma Karadza. "End-to-End Application Billing in 3G." Thesis, Linköping University, Department of Science and Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1654.

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We have 3G on the doorstep but nothing seems to attract ordinary people to this technology. To attract the mass market the telecom industry must show something beyond high bit rates. They must show how ordinary people can take advantage of this new technology. This is done by showing the possibilities of the new technology and by demonstrating applications that it will handle. The telecom industry must convince the telecom operators to invest in this technology and the only thing that matters to them is how much revenue they can make by adopting the upcoming technology.

To convince the operators industry must show how the operators can charge for the new types of applications that will be introduced soon. This is the main reason why this Master's Thesis has been conducted. The purpose of this thesis is to provide a demonstration to Ericsson's 3G lab in Katrineholm in the form of an IP application with a billing solution. This thesis describes the migration from 1G to 3G and examines existing and future billing strategies as well.

The IP application is an application that uses progressive streaming in order to stream multimedia content to a PDA connected to a 3G phone. This application is platform independent because it is placed on leading Web servers, Apache and IIS.

The billing application consists of a number of steps. The first step is logging, which is performed by the Web server on which the streaming application is placed. The second step, processing and billing, is performed in the BGw, which is Ericsson's mediation tool, and the SQL server.The third step is displaying the bill, which is done by using ASP to create an active HTML page.

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Löffler, Daniel. "Eigenschaften und Reaktivität von IPR und non-IPR Fullerenfilmen." [S.l. : s.n.], 2008. http://digbib.ubka.uni-karlsruhe.de/volltexte/1000009893.

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Sconza, Sarah <1976&gt. "Quadri clinici in situazioni di: acidosi metabolica, iper L-lattacidemia e iper D-lattacidemia sperimentalmente indotte nel vitello lattante." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/546/.

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Criollo-Cespedes, Alfredo. "Regulation of autophagy by IP3R and IKK complex." Paris 11, 2009. http://www.theses.fr/2009PA11T099.

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Astutik, Wynda. "IPR Modeling for Coning Wells." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for petroleumsteknologi og anvendt geofysikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-19518.

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In this study, based on the work of Vogel, we generated the Inflow Performance Relationship (IPR) curves and its dimensionless form at any stage of depletion using black-oil simulator results. The IPR was generated for horizontal well with gas and water coning problems, producing from thin oil reservoir sandwiched between gas cap and aquifer. Two empirical IPR equations adopted from SPE paper by Whitson was also presented here. The first empirical relationship was developed based on simulated data for each reservoir pressure (stage of depletion) while the second relationship was developed based on all generated data.A fully implicit black-oil Cartesian model with total grid number of 1480 and 150 ft total thickness was used as reservoir model. The horizontal well extends through the full length of reservoir in y-direction with only one grid number along the horizontal section which makes the model a 2D problem. Sensor reservoir simulator and Pipe-It software were utilized to generate the IPR data.This work also includes a sensitivity study to understand the effect of several parameters to gas and water coning behavior, well placement optimization, coning collapse study, and the effect of coning to maximum well production rate. In coning collapse study, a relationship between flowing bottom-hole pressure and reservoir pressure when the cone collapse is provided in graphical form. This could be useful in field application where chocking the well to lower flowing bottom-hole pressure has become one alternative to reduce coning problems.

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Maslauskaitė, Eglė. "Intelektinės nuosavybės teisių (IPR) muitinis užtikrinimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20100224_134005-74323.

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Baigiamojo magistro darbo tema - „Intelektinės nuosavybės teisių muitinis užtikrinimas“. Darbe keliama problema – intelektinės nuosavybės teisės pažeidimų skaičiaus augimas. Pastebėtina, jog, esant prastai ekonominei padėčiai, intelektinės nuosavybės teisių pažeidėjai pradėjo klastoti ne tik prabangos prekes. Patekusios į rinką klastotos prekės gali pakenkti vartotojui. Tačiau esant blogai ekonominei padėčiai, valstybės institucijoms gaunant mažesnį finansavimą nei įprastai, gali iškilti šių teisių užtikrinimo problema. Darbe keliama hipotezė: Didėjant Lietuvos muitinės veiklos efektyvumui ginant intelektinės nuosavybės teises bei stiprinant kovą prieš klastojimą ir piratavimą, nėra pasiekiamas laukiamas ekonominis efektas. Darbo tikslas: atskleisti intelektinės nuosavybės teisių muitinio užtikrinimo savitumus ir pateikti pasiūlymus dėl veiklos ekonominio efektyvinimo. Darbo uždaviniai: apibūdinti intelektinės nuosavybės svarbą tarptautinėje prekyboje; Išanalizuoti intelektinės nuosavybės apsaugos teisės aktus tarptautiniu ir nacionaliniu lygmeniu bei apžvelgti institucijas, atsakingas už jos įgyvendinimą; apžvelgti muitinės priežiūros priemones, taikomas intelektinės nuosavybės teisių apsaugos srityje; atlikti intelektinės nuosavybės teisių muitinio užtikrinimo Lietuvoje analizę; atliktos analizės pagrindu suformuoti išvadas ir pasiūlymus. pateikti intelektinės nuosavybės teisių muitinio užtikrinimo perspektyvas . Magistro baigiamąjį darbą sudaro keturios dalys:... [toliau žr. visą tekstą]
In order the subjects of intellectual property could participate actively in the international trade, and seeking to avoid unfair competence, their rights must be protected. To this purpose international organizations have been established and a number of international conventions have been signed. Customs plays a very important role while protecting the property that participates in the international trade. The topic of the final master’s thesis is “Customs Protection of Intellectual Property Rights”. The problem raised in the thesis is the increment in number of violation of intellectual property right. It should be noted that in the presence of depressed economic situation the violators of intellectual property rights started falsifying not only luxury goods. Falsified goods, which enter the market, may make harm to the consumers. However, in the presence of depressed economic situation and when national authorities receive lower financing than usually, there may arise a problem of intellectual property rights protection. The thesis has raised hypothesis: While the activity effectiveness of Lithuanian customs is increasing, having protection the rights of intellectual ownership and strengthening the high against falsification and piracy, the expected economic effect is not achieved. The aim of the thesis is to reveal how effectively and economically the Customs of the Republic of Lithuania protects intellectual property rights. The objectives of the thesis are as... [to full text]

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Bentham, J. "The IPPR & Demos : think tanks of the new social democracy." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408362.

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Criollo, Céspedes Alfredo. "Regulación de la autofagia por el receptor del inositol trisfosfato (IP3R)." Tesis, Universidad de Chile, 2009. http://repositorio.uchile.cl/handle/2250/105178.

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Doctor en Bioquímica
La macroautofagia, comúnmente referida como “autofagia” es la principal vía de degradación de proteínas, organelos y material citoplasmático, permitiendo de este modo el reciclaje del material intracelular. Este proceso consiste en el englobamiento de fracciones citosólicas por una estructura multimembranar llamada “autofagosoma”, el cual posteriormente se fusiona con el lisosoma para formar el “autofagolisosoma”. Luego el material comprendido en el autofagolisosoma es degradado por enzimas hidrolíticas. Un estudio mostró que la inhibición de la enzima inositolmonofosfatasa (IMPasa) usando litio y L690.330, inducía una disminución de los niveles basales del IP3 y en consecuencia la generación de autofagia. Nuestros resultados confirmaron estos datos previos, demostrando que el pre tratamiento con mio-inositol revierte la autofagia inducida por litio y L-690.330. Además se demuestra que el pre tratamiento con mio-inositol también revertía la autofagia inducida por privación de nutrientes. IP3 es ligando de su receptor de IP3 (IP3R), el cual es el principal canal de Ca2+ a nivel del retículo endoplásmico. El principal objetivo de esta tesis es evaluar el rol del IP3R en la regulación de la autofagia. Los resultados mostraron que la disminución de los niveles proteicos del IP3R usando siRNA específicos, así como el tratamiento con antagonistas químicos del IP3R, tales como xestosponginas B y C, estimulaban significativamente el aumento en los niveles de autofagia. Además, xestospongina B, así como también la privación de nutrientes, indujo una pérdida en la interacción entre Bcl-2 y Beclin-1, los cuales interactúan en condiciones basales. El tratamiento con xestospongina B no perturbó los niveles de Ca2+, tanto en retículo endoplásmico como en el citosol, concluyendo que la autofagia inducida por xestospongina B es independiente de una fluctuación del Ca2+. Los experimentos de inmunoprecipitación mostraron que Beclin-1 (regulador clave en la inducción de la autofagia) interactúa tanto con IP3R así como con Bcl-2 en condiciones basales, y la interacción de este complejo es atenuado bajo condiciones de privación de nutrientes o por tratamiento con ABT737, el cual es un mimetizador de dominios BH3. Este resultado sugiere la presencia de un complejo proteico en la regulación de la autofagia. El papel del retículo endoplásmico en el desarrollo de la autofagia toma gran significancia debido al reclutamiento de proteínas clave (IP3R, Beclin-1 and Bcl-2). La relación entre autofagia y estrés de retículo no es clara y por lo tanto se evaluó el efecto de agentes inductores de estrés de retículo en la inducción de la autofagia. Los resultados mostraron que tunicamicina, tapsigargina y brefeldina-A (agentes inductores de estrés de retículo) activaron el UPR (respuesta a proteínas mal plegadas) e indujeron autofagia. La disminución de los niveles de proteínas claves en el desarrollo de la autofagia (Atg5, Atg10, Atg12, Vps34 y Beclin-1) usando específicos RNAs interferentes atenuaron la autofagia inducida por agentes inductores de estrés de retículo y xestospongina B. Además, la sobreexpresión de Bcl-2 y Bcl-XL con destinación a retículo endoplásmico atenuó la autofagia inducida por xestospongina B e inhibidores de la IMPasa. Esta tesis muestra novedosos resultados, los cuales dan cuenta de un complejo proteico IP3R/Beclin-1/Bcl-2 en la regulación de la autofagia.
Macroautophagy (herein referred to as “autophagy”) is the major catabolic pathway for entire organelles, long-lived/ aberrant proteins and superfluous portions of the cytosol. It consists of the stepwise engulfment of substrate elements into distinctive multimembraned “autophagosomes”, which after fusion with lysosomes form singlemembraned autophagolysosomes. Into the autophagolysosome, the engulfed material is degradated by lisosomal hidrolytic enzymes, leading the recyclage of intracellular material. A study has suggested that myo-inositol-1,4,5-trisphosphate (IP3) could regulate autophagy because inhibition of inositol monophosphatase (IMPasa) by lithium or L-690.330 stimulates autophagy through the depletion of IP3. Our results have confirmed that the reduction of intracellular IP3 levels by IMPasa inhibitors (lithium and L.690.330) stimulates autophagy, whereas the enhancement of IP3 levels by pre treatment whit mio-inositol inhibits the lithium and L.690.330 effect. Moreover we have demostred that autophagy induced by nutrient privation was also inhibited by treatment with mio-inositol, but the effect of nutrient privation in the intracellular IP3 basal levels was not evaluated. IP3 acts on the IP3 receptor (IP3R), an IP3‑activated Ca2+ channel of the endoplasmic reticulum membrane and consequently we wanted to evaluate de roll of IP3R in the regulation of autophagy. The results obtained in this thesis show that knockdown of the IP3 receptor (IP3R) with specifics small interfering RNAs and pharmacological IP3R antagonist (xestospongin B and C) are a strong stimulus for the induction of autophagy, in addition, xestospongin B (like nutrient starvation) induced loss in the interaction between Beclin-1 and Bcl-2. Moreover, the autophagy promoted by xestospongin B not produced alterations in the steady-state Ca2+ levels in the ER or in the cytosol, therefore the autophagy induced by xestospongin B was Ca2+-independent. Immunoprecipitation assays shown that Beclin- 1 (key protein in the regulation of autophagy) interacts with IP3R and Bcl-2 in basal conditions, and this interaction may be attenuated both by nutrient starvation or ABT737 treatment, which is a mimetic compound of BH3. These results suggest the presence of a protein complex in the regulation of autophagy. The treatment whit ER stressors such as tunicamycin, thapsigargin and brepheldine A induced Unfolded Protein Responses (UPR) and autophagy. The autophagy induced by these agents showed to be IRE1α dependent, but the inhibition of autophagy showed an increase in the cell death, indicating a pro survival function of the autophagy upon endoplasmic reticumum stress conditions. The autophagy induced by treatment with xestospongin B and ER stressors was inhibited by knockdown of Atg5, Atg10, Atg12, Vps34 and Beclin-1, which are keys proteins in the autophagic process. We have also evaluated the roll of Bcl-2 and Bcl-XL in the inhibition of autophgy, and the results showed that Autophagy triggered by IMPasa inhibitors and xestospongin B was inhibited by Bcl-2 and Bcl-XL over expression specifically targeted to ER but not Bcl-2 or Bcl-XL proteins targeted to mitocondria. Altogether, these results suggest that IP3R form a regulator complex with Bcl-2 and Beclin-1, which exerts a major role in the physiological control of autophagy

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Koleszar, Thomas W. "The generation of IPDP micropulsations, with special attention to frequency shift mechanisms." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29132.

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Short period geomagnetic micropulsations termed IPDPs (Intervals of Pulsations of Diminishing Period) are investigated using ground station data, geosynchronous satellite magnetograms, and the Kp and Dst geomagnetic indices. A model for the generation of IPDPs is described, and consideration is given to three mechanisms which could be responsible for the IPDP frequency rise: the inward motion, azimuthal drift, and increasing background magnetic field mechanisms. A simplified IPDP generation model containing the first two of these mechanisms is tested by computer simulation. Results from this simulation indicate the possibility of significant source region inward motion without actual plasmapause displacement, and the possibility of eastward developing IPDPs. Using amplitude variations along a north-south line of ground stations, two methods, each applicable under different ionospheric propagation conditions, are developed for quantitatively determining the inward motion of the IPDP source region. A system for qualitatively determining the potential influence of the increasing background field mechanism on an IPDP using the Dst index and geosynchronous satellite magnetograms is also formulated. Lastly, a technique for the assessment of the effects of the azimuthal drift mechanism, in conjunction with the inward motion mechanism, is developed. This technique assumes that only these two mechanisms are operating. In addition to addressing the frequency shift mechanisms, it provides estimates of the injection boundary position and the magnitude of any (ring current created) magnetic field depression in the IPDP source region. The frequency rises of two IPDPs are analyzed in detail using these methods. In both cases, the inward motion effect is the dominant factor in producing the frequency rise, with the increasing background field mechanism having no significant effect. The azimuthal drift mechanism is a secondary factor in creating one event's frequency rise, and actually suppresses the frequency rise of the other event. The computer simulation calculations also generally show the inward motion mechanism to be the dominant effect in producing IPDP frequency rises. Longitudinal variations within an IPDP event are also examined. The results of this examination are consistent with the IPDP generation model used here, which includes showing significant variations between stations spaced comparatively closely in longitude.
Science, Faculty of
Earth, Ocean and Atmospheric Sciences, Department of
Graduate

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Gottschalk, Eckart [Verfasser]. "Allgemeine Lehren des IPR in kollisionsrechtlichen Staatsverträgen. / Eckart Gottschalk." Berlin : Duncker & Humblot, 2020. http://d-nb.info/1238318150/34.

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Wang, Hui. "Effect of the drilling fluids IPAR and NEODENE on biotransforming enzymes in rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ62438.pdf.

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Alves, André Luiz. "Adubação foliar com silicato na ocorrência de pragas e características agronômicas do feijoeiro comum." Universidade Estadual do Oeste do Paraná, 2016. http://tede.unioeste.br:8080/tede/handle/tede/1327.

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Made available in DSpace on 2017-07-10T17:37:22Z (GMT). No. of bitstreams: 1 Andre_Luiz_Alves.pdf: 1293250 bytes, checksum: 5a9d56042aa0fbe04acf6487951e4e64 (MD5) Previous issue date: 2016-07-22
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The objective of this study was to evaluate both the agronomic performance of two common bean cultivars and the population ocorrence of the main crop pests, according to foliar fertilization with potassium silicate. Experiments were conducted from August to December 2014 and from March to June 2015, under field conditions, in the rural area of Assis Chateaubriand, Paraná, Brazil. A randomized block design was used in both experiments, in a 2 x 5 factorial design, with four replications. The first factor refers to common bean cultivars (IPR Campos Gerais and IPR Tuiuiú), and the second factor refers to the doses of potassium silicate (0.0, 250, 500, 750 and 1000 ml ha-1). The product used contained 0.9 p.v. SiO2 (90 grams per liter of water) and 18% K2O in its formulation, and was diluted in humic acid. In both experiments, doses of potassium silicate were applied during phenological growth stages V3, V4 e R5, R6, R7 and R8 of crops by using the same quantity established for each treatment. The foliar fertilization with potassium silicate did not influence the agronomic characteristics of common bean cultivars, in both crops. IPR Campos Gerais cultivar presented plant height, thousand grain weight and grain yield higher than IPR Tuiuiú cultivar for rainy season crop. IPR Tuiuiú cultivar presented higher grain yield for dry season crop. Foliar fertilization with potassium silicate decreased populational ocorrence of crop pests belonging to Hemiptera, Lepidoptera and Coleoptera orders
Este trabalho teve como objetivo avaliar o desempenho agronômico de duas cultivares de feijoeiro e a ocorrência populacional das principais pragas da cultura em função da adubação via foliar com silicato de potássio. Os experimentos foram conduzidos nos meses de agosto a dezembro de 2014 e nos meses de março a junho de 2015 em condições de campo no município de Assis Chateaubriand-PR, Brasil. O delineamento experimental utilizado foi o de blocos casualizados, em um esquema fatorial 2 x 5, com quatro repetições. O primeiro fator refere-se às cultivares de feijão (IPR Campos Gerais e IPR Tuiuiú) e o segundo fator refere-se às doses de silicato de potássio (0,0; 250; 500; 750 e 1000 ml ha-1). O produto comercial utilizado, continha 0,9 p.v. de SiO2 (90 gramas por litro de água) e 18% de K2O em sua formulação, sendo o produto diluído em ácido húmico. As doses de silicato de potássio foram aplicadas durante os estádios fenológicos V3, V4 e R5, R6, R7 e R8 da cultura em ambos experimentos, sendo utilizada a mesma quantidade do produto estabelecida para cada tratamento nos diferentes estágios fenológicos de aplicação. A adubação foliar com silicato de potássio não influenciou nas características agronômicas das cultivares de feijoeiro em ambas as safras avaliadas. A cultivar IPR Campos Gerais apresentou maior altura de plantas, peso de mil sementes e produtividade de grãos em relação a cultivar IPR Tuiuiú para a safra das águas e a cultivar IPR Tuiuiú apresentou maior produtividade de grãos na safra das secas. A adubação foliar com silicato de potássio proporcionou diminuição na ocorrência populacional das pragas que incidiram sobre a cultura pertencentes as ordens: Hemiptera; Lepdoptera e Coleoptera

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Kölln, Raquel Suzane. "Caracterização nutricional e cinética da degradação ruminal da aveia branca IPR 126 ( Avena Sativa L. CV. IPR 126), sob diferentes níveis de adubação nitrogenada." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2482.

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CAPES; Fundação Araucária; CNPq
O objetivo do presente estudo foi estimar a composição bromatológicas e os parâmetros relativos à cinética de produção de gás in vitro da aveia IPR 126, adubada com diferentes níveis de nitrogênio (0, 60, 120, 240 kg há-1de N), em dois anos de produção (2013-2014).Foi determinada a composição química, sendo analisado: matéria seca (MS) matéria mineral (MM), proteína bruta (PB), extrato etéreo (EE), Fibra em Detergente Neutro (aFDNom), Fibra em Detergente Ácido (FDA), proteína insolúvel em detergente ácido (PIDA), lignina em detergente ácido (LDA),Carboidratos Totais (CT), Carboidratos Não Fibrosos (CNF) e Carboidratos Solúveis (CHOs) da cultivar IPR 126, assim como a estimativa dos parâmetros do modelo bicompartimental para cinética de produção de gases (Vf1, k1, Vf2 e k2 e L). A adubação nitrogenada influenciou apenas os teores de PB e CT em todos os níveis. Em relação às variáveis bromatológicas, LDA, CT, CNF e CHOs foram significativamente superiores em 2013. MM, aFDN e PB foram superiores em 2014. Em 2013, comparando os cortes realizados, a maioria das variáveis bromatológicas não apresentou diferença significativa, com exceção da LDA e CHOs. No ano de 2014, os valores observados das variáveis bromatológicas foram significativamente maiores no 1° corte para EE, CNF e CHOs. Para MM, aFDN, LDA e PIDA foram maiores no 2° corte. Houve efeito significativo em relação aos parâmetros da cinética de degradação produção de gás in vitro, com exceção da L. Na comparação dos anos de cultivo, k1, Vf2 e k2, apresentaram aumento no ano de 2014. No entanto, o Vf1 apresentou redução em 2014. No ano de 2013 comparando os cortes realizados, houve efeito significativo somente para as taxas k1 e k2. Não foram encontradas diferenças significativas em nenhum parâmetro, analisando os cortes de 2014. A aveia branca IPR 126 tem um bom potencial para ser cultivada na região sudoeste do Paraná, porque responde a adubação nitrogenada e consegue expressar seu potencial forrageiro mesmo com condições climáticas desfavoráveis. Os elevados teores de proteína bruta encontrados neste trabalho indicam um desequilíbrio entre as frações proteicas e energéticas, influenciando os parâmetros da cinética de degradação.
The objective of the present study was to estimate the bromatological composition and the parameters related to the in vitro gas production kinetics of oat IPR 126, fertilized with different nitrogen rates (0, 60, 120, 240 kg ha-1 of N), in two Years of production (2013- 2014). The chemical composition was determined: dry matter (DM), crude protein (PB), ethereal extract (EE), neutral detergent fiber (aFDNom), acid detergent fiber (FAD), insoluble protein (LDA), Total Carbohydrates (CT), Nonfibrous Carbohydrates (CNF) and Soluble Carbohydrates (CHOs) of cultivar IPR 126, as well as the estimation of the parameters of the bicompartmental model for kinetics of Production of gases (Vf1, k1, Vf2 e k2 e L). Nitrogen fertilization influenced only PB and CT contents. In relation to the bromatological variables, LDA, CT, CNF and CHOs were significantly higher in 2013. MM, aFDN and PB were higher in 2014. In 2013, comparing the performed cuts, most of the bromatological variables did not present a significant difference, except for LDA and CHOs. In the year 2014, the observed values of the bromatological variables were significantly higher in the 1st cut for EE, CNF and CHOs. For MM, aFDN, LDA and PIDA were higher in the 2nd cut. There was a significant effect in relation to the degradation kinetic parameters in vitro gas production, with the exception of L. In the comparison of the years of cultivation, k1, Vf2 and k2, increased in 2014. However, Vf1 presented a reduction in 2014. In the year of 2013 comparing the cuts performed, there was a significant effect only for rates k1 and k2. No significant differences were found in any parameter, analyzing the cuts of 2014. The white Oat IPR 126 has a good potential to be cultivated in the southwestern region of Paraná, because it responds to nitrogen fertilization and manages to express its forage potential even with unfavorable climatic conditions. The high levels of crude protein found in this work indicate an imbalance between.

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Van, Hoof Bram. "Property indices : Extrapolation of the IPD Japan Capital Growth Index." Thesis, KTH, Bygg- och fastighetsekonomi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-77013.

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The aim of this work is to extrapolate the IPD Japan Capital Growth index series historically back to the early 1980’s. Using existing, long-running, macro-economic and property-related time series as inputs, we will try to set up a statistical model which can extrapolate the existing eight-year track record back for as many years as statistically significant. Our aim is to set up a model which allows us to produce a historical real estate capital growth series going back for 15 to 20 year.

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Wilcox, Trudy. "The stability of coerced economic reform : the case of IPR." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33709.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Political Science, 2005.
Includes bibliographical references (leaves 221-129).
Theories in international relations posit, and empirical evidence has verified, that unwilling states can be compelled by another state or by an international institution to enact domestic policy reform. However, these theories ignore the important follow-on question of whether such externally imposed reforms can be expected to stick. Using intellectual property rights (IPR) reform as a policy case, this dissertation seeks to explain why imposed reform stabilizes in some states but not in others. Here, stable policy means a government demonstrates credible and ongoing commitment to the reform after enacting new law. For example, the state passes additional legal measures to extend the reform, and provides ample support for domestic institutions necessary for the law's implementation. This dissertation presents a comparative study of IPR reform in Brazil and South Korea, covering seven years in the former case and sixteen years in the latter. The Korean government acquiesced to U.S. pressure in 1987 and strengthened its national IPR regime. Brazil undertook IPR reform in 1996, owing in part to its obligation to abide by the directives of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS Accord).
(cont.) The argument put forward is that states commit to imposed reforms once they capture or create reform benefits, and that it is the state itself, not interest groups, that is the principal architect of domestic policy reform. Though states often yield to external pressure and enact policy reform, they are conceding formal compliance (via ratification) but may be feigning functional compliance (i.e., on-the-ground enforcement). In short, the decision to commit to, or backtrack on, imposed reform is made after enactment. Relative gains concerns figure prominently in a state's calculation of what to do post-ratification. Given that the welfare effects of IPR reform are zero-sum in the short term and indeterminate in the long term, states will backtrack on IPR reform to avoid absorbing the concomitant welfare losses. If the state is able to turn unwanted reform to national advantage, then the state commits and the policy stabilizes despite the fact that the reform lacks widespread local acceptance. Principally an empirical study, this research adds needed depth to the current literature on IPR reform in emerging economies.
by Trudy M. Wilcox.
Ph.D.

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Surmeli, Gungor. "The enforcement of intellectual property rights (IPR) in Turkey in the EU accession process : a perception analysis of the police officers dealing with IPR crimes." Thesis, Durham University, 2011. http://etheses.dur.ac.uk/1397/.

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Intellectual property rights (IPR) has become one of the most debated issues, particularly in recent years due to its relevance and importance in the intellectual, economic and industrial fields. It is widely accepted that the protection of IPR plays a crucial role in intellectual and technological developments as well as research and development (R&D) activities. Turkey has been a party to several international treaties and conventions in terms of protection of IPR. While IPR legislations can be traced back to the Ottoman Empire time; the proactive developments with regard to IPR issues were initially expedited within the process of the Customs Union in 1995 and then with the commencement of the European Union (EU) accession negotiations in 2005. Intellectual Property (IP) law is one of the chapters that has to be adopted in accordance with the EU legislations. Therefore, harmonisation of IP law has an important function for Turkey in the EU accession process, but also is a requirement. In addition to the importance of legislative developments, enforcement of IPR is also essential in terms of preventing piracy and counterfeiting. Therefore, this research aims to explore the enforcement of IPR in Turkey in the EU accession process by focusing on the perceptions of the main enforcers, namely police officers dedicated to deal with IPR-related crimes. In fulfilling the identified aim, apart from the secondary sources such as documents presented in the negotiations with the EU, a questionnaire schedule was administered with the police officers with the objective of gathering primary data. After exploring and analysing various issues related to IPR crimes and its enforcement, the research explores the challenges encountered by the police officers dealing with IPR crimes and then indicates the precautions and recommendations for an effective enforcement system in the fight such crimes. The main findings of the research indicate that, as perceived by the participants, the fight against IPR crimes should be carried out by specialised IPR units, as anti-piracy commissions are not working satisfactorily; and a single organisation should be established in order to deal with both copyright and industrial property rights. In addition, it is perceived by the majority of the respondents that legislative and administrative measures should be considered in order to overcome the problems related to IPR challenges, and there is a connection between IPR criminals and organised crime groups. Furthermore, the findings suggest that IPR education can be added to the curriculum at schools. While the Turkish police have made considerable developments with regard to the protection of IPR issues both in administrative and enforcement aspects, the research indicates that there are further issues to be tackled to bring about a more efficient and effective IPR enforcement system in Turkey.

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Lesonický, Michal. "Rizika při sestavování a vedení pracovních týmů." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-401072.

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The diploma thesis deals with the risks related to team building and management in company Profi FP, which offers financial advisory within its activities. The thesis is divided into three parts. The theoretical part is devoted to the professional description of selected topics related to the topic of the thesis. The following section focuses on the general characteristics of the company, the analysis of the current status of assembling and leading the teams, and analyzing the risks associated with leading and setting up the teams in the company. The last part deals with proposals for measures and team activities, which would eliminate or minimize the most risky factors and processes in leading and setting up teams, thus improving these processes in the selected company.

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Georgeon, Chartier Carole. "Evaluation des effets du vieillissement sur la signalisation calcique des cellules musculaires lisses des artères cérébrales dans les modèles murins C57BL6/J, SAMR1 et SAMP8 dans des conditions normales et sous restriction calorique." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14692/document.

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Au cours du vieillissement, les artères cérébrales subissent des modifications structurelles et fonctionnelles, notamment au niveau des cellules musculaires lisses (CML). La CML a pour rôle de maintenir la réactivité vasculaire via une signalisation calcique qui fait intervenir différents acteurs pouvant ainsi réguler deux phénomènes : la contraction et la relaxation. Ces acteurs rassemblent, au sein d’une même cellule, des canaux (CCVD, RYR, IP3R), des pompes calciques (SERCA, PMCA, NCX, STIM/ORAI) et leurs régulateurs (PLB, FKBP12.6, TRPP2, SARAF, TRIC). La restriction calorique (RC), apparaît comme étant un facteur retardant le vieillissement et ses pathologies. Notre travail s’est donc fortement impliqué dans l’étude de la signalisation calcique de la CML, en se focalisant sur les altérations génomiques et fonctionnelles au cours du vieillissement des artères cérébrales chez la souris C57Bl6/j. Nous avons ainsi pu mettre en évidence une altération de la signalisation calcique qui passe en partie par une modulation des niveaux d’expressions génique et protéique des canaux et pompes calciques impliqués dans ce phénomène, et par une modification fonctionnelle en termes de signaux calciques et de contraction. Après 5 mois de régime RC, il a été mis en évidence un ralentissement des altérations de la signalisation calcique liées au vieillissement et une diminution de l’oxydation des CML
During aging, cerebral arteries undergo structural and functional changes, particularly in smooth muscle cells (SMC). SMC is responsible for maintaining vascular reactivity via calcium signaling involving different actors and can regulate two phenomena: contraction and relaxation. These actors regroup channels (CCVD, RYR, IP3R) calcium pumps (SERCA, PMCA, NCX, STIM / ORAI) and their regulators (PLB, FKBP12.6, TRPP2, SARAF, TRIC). Caloric restriction (CR) appears as a factor in delaying aging and its pathologies. Our work is strongly involved in the study of calcium signaling in SMC, focusing on genomic and functional alterations during aging of cerebral arteries in mice C57BL6/J. We were able to demonstrate an altered calcium signaling, which is partly through modulation of gene and protein expression levels of calcium channels and pumps involved in this phenomenon, and a functional change in terms of calcium signals and contraction. After 5 months under RC, it was highlighted a slow calcium signaling alterations associated with aging and a decrease of SMC oxidation by SAMP8

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Huang, Wenting. "IPR Barriers in Collaboration between University and Engineering Industry in Sweden." Thesis, KTH, Samhällsekonomi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48720.

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This thesis examines the barriers, especially intellectual property rights concerned that inhibit industry academia collaboration. By analyzing Swedish firms in the engineering industry, I explore the influence of IPR barrier on firms’ benefits, short- and long-term respectively from university-industry interaction. Three hypotheses are suggested to investigate the relationship between IPR barriers, firm categories, short-term benefits and long-term benefits. The results illustrate different firms’ reactions to IPR barriers. According to the analysis, advanced firms are more likely to report IPR barriers. Moreover, they tend to benefit more in the long run. However, the short-term benefits from UI collaboration seem to have no significant relationship with IPR barriers. There is hence no proof in the data that IPR barriers are a significant hinder for firms to benefit from university-industry interaction.

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Qin, Ruiting. "Parteiautonomie : eine rechtsvergleichende Untersuchung : Versuch zur Entwicklung einer Gerechtigkeitsjurisprudenz im IPR /." Frankfurt am Main [u.a.] : Lang, 2003. http://www.gbv.de/dms/spk/sbb/recht/toc/372480020.pdf.

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Zorn, Antje [Verfasser]. "Vergleich verschiedener Methoden zur Kieferrelationsbestimmung mithilfe des IPR-Systems / Antje Zorn." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079524983/34.

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Pila, Huancachoque Yuri Gabriel. "Integrated Project Delivery (IPD): Un marco integrador de ejecución de proyectos." Civilizate, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/114657.

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Los proyectos de construcción suelen tener relaciones adversarias entre colaboradores, bajos ratios de productividad, alto grado de ineficiencia y re trabajo, frecuentes disputas y poca innovación. Como resultado, se tienen proyectos que son muy costosos y que no cumplen con los plazos especificados. Este panorama puede ser visto desde enfoques diversos de solución, empezando por la mejora de la productividad, la tecnología, entre otros. Sin embargo, es necesario revisar las bases mismas de la relación entre las empresas que forman parte de un proyecto y, a partir de ello, presentar un nuevo modo de trabajo colaborativo: el IPD, un marco de trabajo integrador de resultados fascinantes.

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Jenkins, Giuseppi K. "Implementing IPD Principles on Custom Residential Projects: Tools and Best Practices." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7508.

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The purpose of this research is to see how Integrated Project Delivery (IPD) principles and practices can be used on high end custom residential construction projects to increase the collaboration and efficiency of the project team. A case study was conducted on a custom home project to observe how and what IPD principles were used. Observations, interviews and a survey were used as part of that case study to gain insights. This research found that IPD principles and practices could be used on residential projects. In addition, the research found that those involved found the experience positive and beneficial to their success on the project.

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Mataragka, Stefania. "High-resolution optical analyses of IP3-evoked Ca2+ signals." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289124.

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Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they bind IP3 produced after activation of cell-surface receptors. Vertebrate genomes encode three closely related subtypes of IP3R (IP3R1-3). High-resolution optical analyses have revealed a hierarchy of IP3-evoked Ca2+ signals that are thought to arise from the co-regulation of IP3Rs by IP3 and Ca2+. The smallest events ('blips') report the opening of single IP3Rs, Ca2+ 'puffs' report the almost simultaneous opening of a few clustered IP3Rs, and as stimulus intensities increase further Ca2+ signals propagate regeneratively as Ca2+ waves. The aim of this study was to establish whether all three IP3R subtypes can generate Ca2+ puffs. I first used a haploid cell line (HAP1 cells) to generate, using CRISPR/Cas9, a line lacking all endogenous IP3Rs. However, for analyses of Ca2+ puffs, I used HEK cells that had been engineered, using CRISPR/Cas9 to disrupt endogenous genes, to express single IP3R subtypes. Local Ca2+ signals evoked by flash-photolysis of caged- IP3 were recorded using Cal520 and total internal reflection fluorescence (TIRF) microscopy in human embryonic kidney (HEK) cells. The Flika algorithm was used, and validated, for automated detection of Ca2+ puffs and to measure their properties. IP3 evoked Ca2+ puffs in wild-type HEK cells and in cells expressing single IP3R subtypes. In wild-type cells, the Ca2+ signals invariably propagated regeneratively to give global increases in cytosolic [Ca2+]. This occurred less frequently in cells expressing single IP3R subtypes, commensurate with their lower overall levels of IP3R expression. The properties of the Ca2+ puffs, including their rise and decay times, durations, the size of the unitary fluorescence steps as channels closed channel during the falling phase, and the estimated number of active IP3Rs in each Ca2+ puff, were broadly similar in each of the four cell lines. The latter observation suggests that despite lower overall levels of IP3R expression (~30%) in cells with single subtypes relative to WT cells, there is a mechanism that ensures formation of similarly sized IP3R clusters. The only significant differences between cell lines were the slower kinetics of the Ca2+ puffs evoked by IP3R2, which may suggest dissociation of IP3 from its receptor contributes to the termination of Ca2+ puffs. My results demonstrate, for the first time, that all three IP3R subtypes can generate Ca2+ puffs. I conclude that Ca2+ puffs are fundamental building blocks of all IP3-evoked Ca2+ signals.

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Ritaine, Abigaël. "On the mechanisms of regulation of the IP3R activity by its interaction with Bcl-2." Thesis, Lille, 2018. http://www.theses.fr/2018LIL1S101.

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L’homéostasie calcique est régulée par de nombreux canaux ioniques, parmi lesquels des canaux intracellulaires perméables au Ca2+, comme l’IP3R. Récemment, la protéine Bcl-2 a été montré comme régulant l’activité de ce canal ionique. Cependant, les acteurs moléculaires précis de cette interaction ne sont pas très bien établis. Ici nous montrons grâce à une nouvelle technique que l’IP3R est inhibé par le domaine BH4 de Bcl-2 et que ce domaine est nécessaire et suffisant pour inhiber son activité. De plus, la liaison de l’ABT-199 dans la poche hydrophobe de Bcl-2 conduit à un changement de structure du domaine BH4. Le niveau d’expression des différentes isoformes d’IP3R ainsi que des protéines Bcl-2 et Bcl-xL ont été étudié dans différentes lignées cancéreuses prostatiques. De manière intéressante, l’expression du récepteur à l’IP3 de type 3 (IP3R3) est augmentée en fonction de l’agressivité des lignées cancéreuses prostatiques. De plus, nous pouvons observer un effet important de l’IP3R3 sur la migration et l’invasion des lignées humaines de cancer de la prostate. Globalement, ces données montrent que l’IP3R3 participe à l’augmentation du potentiel métastatique des cellules cancéreuses prostatiques. Par conséquent, l’IP3R3 peut être un marqueur diagnostic intéressant ainsi qu’une cible thérapeutique, notamment pour les stades avancés de cancer de la prostate
Calcium homeostasis is regulated by various ion channels, among which intracellular Ca2+-permeable channels, such as IP3R. Lately, Bcl-2 protein have been shown to regulate this ion channel activity. However, the study of the functional properties of IP3R in interaction with Bcl-2 is not a straightforward procedure and the molecular players implicated in that interaction are still not well established. Here, we show with the use of a new electrophysiological method, that the IP3R is inhibited by Bcl-2 via its BH4 domain and that the BH4 domain of Bcl-2 can inhibit by itself the single channel activity of the IP3R. Moreover, the binding of the ABT-199 in the hydrophobic groove of Bcl-2 leads to a tail-flip structural change in BH4 domain. We also studied the expression level of different IP3R isoforms as well as Bcl-2 and Bcl-xL protein in different prostate cancer cell lines. Interestingly, IP3R type 3 (IP3R3) expression is increased according the aggressiveness of prostate cancer cell lines. Indeed, IP3R3 was expressed preferentially in highly aggressive prostate cancer cell lines. Moreover, we can observe an significantly important effect of the IP3R3 on migration and invasion properties of human prostate cancer cell lines. Our study also revealed that IP3R3 was not involved in viability, proliferation. Overall, these data provide evidence on IP3R3 contribution to the increased metastatic potential of human prostate cancer cells. Therefore, IP3R3 could provide new perspective molecular target for the disease suppression, in particular at its advances stages

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Dočkalová, Pavla. "Proaktivní analýzy rizik v podnikové praxi - metody a postupy." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-446768.

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The diploma thesis deals with proactive risk analysis in company X, which manufactures mainly meat products. The thesis is divided into 2 parts. The first part concentrates on theoretical knowledge including a list of methods suitable for risk analysis. This part also includes the introduction of the company, description of processes into the company, and actual risk management. The second part includes risk analysis with the IPR method and FMEA method. Based on the results of the applied methods, measures to minimize the identified risks are proposed at the end of the work.

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Larsson, Sofia. "Hur påverkar IPR överföring av utsläppsminskande teknologi från Sverige till utvecklingsländer ur ett hållbart perspektiv?" Thesis, Södertörn University College, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-3025.

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Studien syftar till att besvara frågeställningen: Hur påverkar immateriella rättigheter teknologiöverföring från Sverige till utvecklingsländer ur ett hållbart perspektiv? Detta görs genom studier av aktuell forskning i ämnet samt intervjuer med relevanta parter som på ett eller annat sätt verkar inom området överföring av utsläppsminskande teknologi från Sverige till utvecklingsländer.

Studien visar att det finns två huvudsakliga perspektiv på hur IPR påverkar teknologiöverföring av utsläppsminskande teknologi från Sverige till utvecklingsländer. Det ena perspektivet är ett i-landsperspektiv som generellt betonar att IPR inte utgör ett hinder utan snarare en drivkraft för att överföring skall vara möjlig. Det andra perspektivet är ett u-landsperspektiv som betonar att IPR utgör ett hinder i och med att det har en fördyrande effekt på innovativ teknologi. Utvecklingsländer har inte råd att köpa teknologin, enligt det senare perspektivet. Det kan vara ett fattigdomsproblem och inte ett problem direkt relaterat till IPR.

Studien visar också att överföring av utsläppsminskande teknologi från Sverige till utvecklingsländer på kommersiell väg sker i väldigt liten mån. Den överföring som sker är i majoritet till de ekonomiskt mest välbärgade u-länderna som Kina, Brasilien och Indien. Överföringen som sker via statligt stöd är likaså begränsad och går även den i huvudsak till länder som kommit relativt långt i sin utveckling. De mindre utvecklade u-länderna står i princip helt utan överföring av utsläppsminskande teknologier.

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Montecino, Rodriguez Encarnación M. "Etudes des mutations Ipr et gld induisant un syndrome autoimmun dans le contexte génétique murin C57BL/6 : transfert du syndrome par greffe de cellules hématopoiétiques dans des receveurs irradiés subléthalement : analyse du rôle de la population cellulaire T Ipr dans la pathologie autoimmune Ipr /." [S.l.] : [s.n.], 1990. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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陶, 晟辰. "循環器における小胞体タンパク質TRICに関する研究." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188726.

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Cadena, Torrico Jose Ramiro. "Desenvolvimento analitico das curvas IPR a partir de um simulador de reservatorios." [s.n.], 1995. http://repositorio.unicamp.br/jspui/handle/REPOSIP/264651.

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Orientador: Denis Jose Schiozer
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica
Made available in DSpace on 2018-07-21T02:05:33Z (GMT). No. of bitstreams: 1 CadenaTorrico_JoseRamiro_M.pdf: 925185 bytes, checksum: fbfdb9dd063f44375c69ff742610db93 (MD5) Previous issue date: 1995
Mestrado

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Al, Subaih Adel. "A framework for implementation of IPD principles in oil & gas projects." Thesis, University of Salford, 2016. http://usir.salford.ac.uk/41093/.

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Investment in the global Oil and Gas sector is huge. In 2014, the cumulative investment in between 2014 and 2035 was estimated to be US$22.4 trillion, equivalent to an average annual spend of more than US$1 trillion. A high percentage of Oil & Gas projects go over budget, however, because of poor performance and major schedule delays. Many of these can be traced to problems originating in the design phase. This phase is typically carried out by experienced design consultants, followed by tendering and then execution, involving large construction organisations. Project delivery methods in the sector vary, with 57% using Design-Bid-Build, 38% Design-Build, and 5% Construction Manager at Risk. These methods provide no clear integration or collaborative approaches to ensure stakeholders involvement early during the design phase. This research examines the potential for using Integrated Project Delivery (IPD) as a new approach to improve collaboration by engaging full project teams from early in the design phase. It addresses the following questions: How do current practices in the Oil & Gas sector influence project performance? What are the factors behind poor project performance, and how can project performance be improved by the implementation of IPD? The aim of this research is to create a conceptual framework to implement IPD principles in Oil & Gas projects as a way of improving their performance. This framework will help project stakeholders to be involved during the design phase, which in turn will help to deliver high quality projects, where schedule and costs are tightly controlled. An extensive literature review found 1,056 factors affecting performance, of which 85 could be resolved if addressed at the design phase. A total of 55 factors were related to communication, project management, planning and design problems. A conceptual framework was created to equip stakeholders with a tool to implement IPD effectively. This framework was validated using case studies of very large Oil & Gas projects. This confirmed the criticality of the factors identified, and that they occurred during particular project stages. The framework was structured by plotting the major project stakeholders on one side and the project phases on the other (design phase, tendering, and construction), followed by the performance factors related to project management, planning, design and communication. For each factor, the stakeholders responsible were identified. The research concluded that the Oil & Gas industry suffers from poor performance and the current practices and execution strategies are influencing project delivery. There is a clear gap between the design and construction phases. The conceptual framework developed here will help to improve project performance by bridging the gap and involving all the stakeholders during the design phase, making sure that all the identified poor performance factors can be managed by all those affected, at the most suitable time. The framework is also expected to resolve other factors related to resources, procurement, environment and contracting which are linked to design, planning and project management factors.

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Henk, Alexander [Verfasser]. "Die Haftung für culpa in contrahendo im IPR und IZVR. / Alexander Henk." Berlin : Duncker & Humblot, 2010. http://d-nb.info/1238356885/34.

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Bonneau, Benjamin. "Implication des protéines de la famille Bcl-2 dans la régulation des flux calciques au cours du développement embryonnaire précoce du poisson zèbre." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10155/document.

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L'apoptose est un processus cellulaire fondamental pour l'homéostasie tissulaire. Ce type de mort cellulaire est sous le contrôle des protéines de la famille Bcl-2 qui régulent la perméabilité de la membrane externe de la mitochondrie. Cependant, au-delà de leur rôle dans le contrôle de l'apoptose, les protéines de la famille Bcl-2 peuvent intervenir dans d'autres processus tels que le cycle cellulaire ou le métabolisme. Au sein du laboratoire, nous nous intéressons tout particulièrement aux rôles non-apoptotiques des protéines Bcl-2 au cours du développement embryonnaire. Grâce à l'utilisation du poisson zèbre, nous avons pu montrer que les protéines de la famille Bcl-2 contrôlent différents processus au cours du développement grâce à leur capacité à réguler l'homéostasie calcique. En effet, nous avons montré que la protéine anti-apoptotique Nrz participe au remodelage du cytosquelette d'actine au cours de l'épibolie en régulant la concentration de calcium cytosolique par son interaction avec le récepteur à l'IP3 (IP3R). Nous avons de plus pu montrer que Nrz diminue la sortie de calcium du réticulum endoplasmique en inhibant la fixation de l'IP3 sur son récepteur. Nous avons également identifié un nouveau membre pro-apoptotique de la famille Bcl-2, Bclwav, spécifiquement exprimée chez les poissons et le xénope. Cette protéine participe à la régulation de l'homéostasie calcique mitochondriale en interagissant avec VDAC. Nous avons de plus montré que cette activité est essentielle pour les mouvements de convergence et d'extension au cours du développement embryonnaire précoce du poisson zèbre
Apoptosis is a key cellular process for tissue homeostasis. Apoptotic cell death is under control of Bcl-2 family proteins which regulate outer mitochondrial membrane permeability. However, beyond their role in apoptosis, Bcl-2 family proteins are also involved in other cellular processes such as cell cycle or metabolism. In our laboratory we are interested in non-apoptotic functions of Bcl-2 family proteins in embryonic development. Using zebrafish model we have shown that Bcl-2 proteins control different processes during early development thanks to their ability to regulate calcium homeostasis. Indeed, we have shown that the anti-apoptotic protein Nrz participates in actin cytoskeleton remodeling during epiboly by regulating cytosolic calcium concentration via an interaction with the IP3 receptor (IP3R). We have also demonstrated that Nrz decreases calcium release from the endoplasmic reticulum by inhibiting IP3 fixation on its receptor. We have furthermore identified a new pro-apoptotic member of Bcl-2 family, Bcl-wav which is expressed only in fish and frogs. This protein regulates mitochondrial calcium homeostasis by interacting with VDAC. We have moreover shown that this activity is essential for convergence and extension movements during early zebrafish development

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Malou, Nada. "Adaptation de l'immuno-PCR pour le diagnostic des maladies infectieuses." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20692.

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Cette thèse présentait comme objectif mettre en évidence le potentiel apport de l’immuno-PCR dans le diagnostic des maladies infectieuses à travers 3 exemples. L’application de l’iPCR dans le diagnostic précoce de la fièvre Q aiguë via la détection des IgM Phase II anti Coxiella burnetii a permis de détecter 90% des sérums prélevés dans les 2 premières semaines après l’apparition des symptômes contre 55% détectés par PCR, 38% par ELISA et 35% par l’IF la technique de référence. De plus une spécificité de 92% a été retrouvée par iPCR, 100% par PCR et l’IF et 90% par ELISA. L’application de l’iPCR à la fièvre Q aiguë constitue un exemple d’application de la technique plus globalement pour tous types d’infections aiguës. D’autre part, dans le cadre de la mise au point d’un modèle expérimental murin d’infection à Tropheryma whipplei, l’iPCR a servi à mesurer la réponse immunitaire mucosale via la détection des IgA anti T. whipplei dans les selles de souris. Les résultats obtenus ont permis de confirmer le rôle de la bactérie comme agent de gastroentérite via entre autre la détection d’IgA anti T. whipplei dans les selles lorsque des atteintes intestinales étaient provoquées. Enfin l’’utilisation de l’iPCR pour la détection de l’antigène Y. pestis dans des dents anciennes a permis de confirmer Y. pestis comme agent étiologique de la peste noire dans 5 charniers à travers la France et l’Italie. Une sensibilité de 41% a été retrouvée par iPCR contre 32% par PCR et 10% par ELISA. Nos résultats suggèrent que la détection des antigènes et la détection de l’ADN du pathogène semblent être 2 approches complémentaires permettant de confirmer le rôle de Y. pestis dans les différentes pandémies de peste et de mettre fin aux controverses suscitées par la seule utilisation des techniques de biologie moléculaire.Globalement, les résultats que nous avons obtenus au cours de cette thèse démontrent le potentiel énorme de l’iPCR comme technique de détection des anticorps et d’antigènes dans le domaine des maladies infectieuses tant au niveau de la sensibilité de détection qu’au niveau de son adaptabilité à différentes applications
The objective of this thesis was to highlight the potential contribution of immuno-PCR in the diagnosis of infectious disease through 3 examples of infection. The iPCR was adapted for the early diagnosis of acute Q fever by the detection of IgM anti phase II Coxiella burnetii in patient’s sera. The results that we obtained show that iPCR could allow an early diagnosis of acute Q fever since 90% of early sera of patients with acute Q fever collected during the 2 first weeks after the onset of symptoms are detected against 55% by PCR, 38% by ELISA and 35% by IFA the gold standard. In addition, a specificity of 92% was found by iPCR, 90% by ELISA and 100% by PCR and IF. Application of iPCR to the diagnosis of acute Q fever is an example of application of the technique more generally for all types of acute infections. In a second time, the use of iPCR for the detection of Yersinia pestis antigen in ancient teeth allowed a confirmation of its role as the etiologic agent of plague in five mass graves across France and Italy. A sensitivity of 41% was recovered by IPCR against 32% by PCR and 10% by ELISA. Our results suggest that antigen and DNA detection of pathogen in ancient samples are 2 complementary approaches allowing the confirmation of the role of Y. pestis in different plague pandemic. Finally, as part of the development of an experimental murine infection with Tropheryma whippleii, the iPCR was used to measure the mucosal immune response via the detection of IgA anti T. whippleii in mouse stools. The results have confirmed the role of the bacterium as an agent of gastroenteritis via the detection of IgA anti T. whipleii in the stool when intestinal damages were caused.Overall, the results that we obtained during my thesis demonstrate the enormous potential of iPCR as a diagnostic tool of infectious disease by the ultrasensitive detection of antigens and antibodies

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Gája, Filip. "Proaktivní analýzy rizik v podnikové praxi - metody a postupy." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-433326.

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Diploma thesis focuses on the issue of proactive risk management in companies, using appropriate procedures and methods in the selected company. Thesis is divided into three parts. First part is focused on theoretical knowledge, which serves as a basis for the analytical part. The analytical part characterizes the selected company, organizational structure, job positions and key processes in the company, with a focus on proactive risk management. In the last part of the diploma thesis, measures for proactive risk detection are suggested.

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Bartoň, Andrej. "Prevence selhání lidského činitele při rizikových činnostech." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-414108.

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The diploma thesis focuses on the issue of human error in risk activities. The issue is examined at a company InfoTel, spol. s r. o. offering professional services in the construction and operation of telecommunication networks. The work is divided into three parts. The first part is aimed at obtaining theoretical background serving as a starting point for the subsequent analytical part. The analytical part concentrates on the characteristics of the selected company, organizational structure and work positions. It includes the analysis of corporate processes, contemplating the human factor, its activity and associated risks. The final part of the thesis is devoted to proposals for measures, focusing on prevention of human error in risk activities, leading to improvement of economic result in the selected company.

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Beachley, Gregory Marcus. "An improved pseudo-deterministic receptor model (iPDRM) to apportion ambient PM constituents to sources in Tampa, FL." College Park, Md. : University of Maryland, 2009. http://hdl.handle.net/1903/9835.

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Thesis (Ph.D.) -- University of Maryland, College Park, 2009.
Thesis research directed by: Dept. of Chemistry and Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Téchio, Kachia Hedeny. "Transformando a água em sangue: uma análise sobre a exportação evangélica brasileira através das perfomances da IPDA." Doctoral thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa, 2011. http://hdl.handle.net/10362/6270.

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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Doutor em Antropologia.
Esta tese teve como ponto de partida pensar a imigração enquanto desorganizador e reorganizador social buscando identificar aspectos fundantes na construção/manutenção das representações identitárias dos interlocutores (imigrantes brasileiros pentecostais), quais marcas fundamentais que o caracterizariam e verificar a existência de um pensamento inclusivo ou exclusivo. Ainda, considerando-se que meios diferentes, ou ‗ecologias culturais diversas‘ forçam adaptações diferentes, analisar o papel da igreja IPDA – Igreja Pentecostal Deus é Amor, nas estratégias de desterritorialização e territorialização dos imigrantes brasileiros em Portugal e na Inglaterra. O trabalho de pesquisa foi realizado de Maio/2006 a Dezembro/2009 entre Brasil e Portugal e trabalhou-se com um universo de 1.200 membros fixos na IPDA portuguesa, cerca de 5000 membros cadastrados na IPDA brasileira e cerca de 50 membros na Inglaterra Observou-se que mesmo após quarenta e nove anos de existência e contacto com diferentes culturas em mais de cento e trinta países a IPDA conserva inalteradas as doutrinas prescritas pelo fundador mantendo-se no nicho do mercado religioso onde foi fundada e tornando-se líder. Na prática a IPDA só mantem-se e permanece em funcionamento graças a sua estratégia de combinar uma ‗doutrina rígida‘ com ‗santificação‘. Dessa combinação resultou um estilo pentecostal próprio que expressa o ajustamento da igreja frente a novas situações do panorama pentecostal demonstrando, assim, a capacidade de resistência da IPDA ante a situação de contacto, e capacidade de reorganizar seus códigos culturais para enfrentar os desafios do quotidiano. A identidade pentecostal do grupo em questão pode ser considerada como um produto de uma matriz originada em um local distante – nos Estados Unidos – e marca de um grupo pentecostal específico que, ao ser fundado no Brasil, procurou elevar ao maximo denominador comum suas crenças e valores. Ao transpor essa identidade para o espaço da imigração brasileira, em Portugal, mais uma vez o grupo decidiu realçar suas diferenças para fazer-se notar frente aos ‗outros‘ brasileiros e ‗outros‘ pentecostais ali existentes. Dentro da proposta inicial desta tese, conclui-se que a IPDA fornece os meios de sustentar a continuidade cultural, apesar do deslocamento geográfico, e de manter a membrasia em novos contextos através da repetição de suas performances. A IPDA encontrou seu ‗lugar‘ e desempenha um papel importante na manutenção e reprodução das representações identitárias entre os imigrantes brasileiros pentecostais e as sociedades receptoras. Pode-se dizer que as representações e performances pentecostais permitem a difusão dessa identidade religiosa brasileira. As representações das identidades colectivas, entre elas a pentecostal, estabelecem pontes simbólicas utilizadas como peças axiais pelos indivíduos para inserirem-se na comunidade receptora. Importa ainda observar as diversas formas pelas quais a representação da identidade pentecostal contribui para a manutenção/reconfiguração dessa comunidade brasileira/pentecostal imaginada. A ‗identidade‘ dessa comunidade imaginada que está baseada nas performances pentecostais dos imigrantes brasileiros alcança a todos os cidadãos brasileiros dentro e fora do país, mesmo aqueles que não proferem nenhuma fé. Entretanto, essa identidade pode alcançar de forma negativa os brasileiros ou os habitantes não identificados com as práticas do pentecostalismo, uma vez que acabam excluídos da comunidade que, de certa forma, desprestigia outras culturas.

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Li, Heli. "RF LOW PASS FILTER DESIGN AND FABRICATION USING INTEGRATED PASSIVE DEVICE TECHNOLOGY." Master's thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4340.

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In this thesis, the whole process of design a low pass filter (LPF) for the wireless communication application has been presented. Integrated passive device technology based on GaAs substrate has been utilized to make the LPF. Schematic simulation and electromagnetic simulations are extensively used in the design process. EM simulation is used in the selection of layout design and processing parameters for design optimization of both the inductors and IPD harmonic filters. The effective use of EM simulation enables us to realize the successful development of high performance harmonic filters. To make the optimization be more flexible and also for a deeper understanding of the optimization theory, optimization using genetic algorithm is also implemented. The weight of each targets are adjustable, and a non-uniformly distributed goal for the harmonic rejection range is introduced to achieve better optimization results. The embedded LPF is built and measurement results show good agreement with the simulation data. This kind of very compact, high performance harmonic filters can be used in radio transceiver front-end modules. The realized harmonic filters have insertion loss less than 0.6 dB and harmonic rejections greater than 25 dB with a compact die size of 0.8 mm2.
M.S.E.E.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering

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Dalle, Hugo Moura. "Simulação do reator TRIGA IPR-R1 utilizando metodos de transporte por Monte Carlo." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267210.

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Orientador: Elias Basile Tambourgi
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
Made available in DSpace on 2018-08-04T19:28:53Z (GMT). No. of bitstreams: 1 Dalle_HugoMoura_D.pdf: 6728358 bytes, checksum: 2c3bf749417a0e9182de201824e76cdd (MD5) Previous issue date: 2005
Resumo: A utilização do método Monte Carlo na simulação do transporte de partículas em reatores nucleares é crescente e constitui uma tendência mundial. O maior inconveniente dessa técnica, a grande exigência de capacidade de processamento, vem sendo superado pelo contínuo desenvolvimento de processadores cada vez mais rápidos. Esse contexto permitiu o desenvolvimento de metodologias de cálculo neutrônico de reatores nas quais se acopla a parte do transporte de partículas, feita com um código de Monte Carlo, ao cálculo de queima e decaimento radioativo. Neste trabalho tal metodologia de simulação é implantada, validada para reatores de pesquisas, notadamente os do tipo TRIGA e finalmente utilizada na simulação neutrônica do reator TRIGA IPR ¿ RI do CDTN/CNEN. O sistema de códigos empregados é constituído pelos amplamente utilizados códigos MCNP4B (transporte por método Monte Carlo) e ORIGEN2.1 (queima e decaimento radioativo). Apesar dos esforços recentes no sentido de agrupar as duas etapas de cálculo, transporte e queima, em um único código, até o momento esta opção não está disponível e, portanto, um terceiro código é utilizado para realizar o acoplamento transporte/queima. Neste trabalho utilizou-se para tal o código MONTEBURNS. O sistema formado por estes três códigos permitiu obter os parâmetros neutrônicos de interesse do IPR ¿ R1 através apenas de simulação teórica, sem a necessidade de qualquer tipo de ajuste baseado em dados experimentais, em boa concordância com os valores medidos... Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital
Abstract: The use of Monte Carlo methods in particles transport simulations of nuclear reactor is growing fast and constitutes a strong tendency all over the world. The major inconvenient of such techniques is the huge demand of processing power which has been surpassed the development of reactor physics calculation methodologies in which the particles transport part, made by a Monte Carlo transport code, is linked with the burnup and radioactive decay part of the simulation. On this work a such simulation methodology is made operational, validated for research reactors, mainly for TRIGA reactor and finally utilized for reactor physics simulation of the CDTN¿s TRIGA IPR ¿ R1. The adopted codes system is constituted by the widespreadly used codes MCNP4B (Monte Carlo transport) and ORIGEN2.1 (burnup and radioactive decay). In spite of the very recent efforts toward get together both, transport and burnup, in only one code at the moment this is a not available option and therefore, a third code is needed to carry out the linkage transport/burnup. MONTEBURS code was used to this purpose. This three codes system has allowed to obtain the physical parameters of IPR ¿ R1 calculated using only theoretical simulation without any kind of experimental adjustment or interaction between experiments and calculation in good agreement with measured values... Note: The complete abstract is available with the full electronic digital thesis or dissertations
Doutorado
Sistemas de Processos Quimicos e Informatica
Doutor em Engenharia Química

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Tøgersen, Stig-Ole Berg. "Intellectual property and scientific research : A study of the interaction between IPR and research." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for industriell økonomi og teknologiledelse, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-21080.

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The impact of intellectual property rights on innovation has been a fundamental concern of law- and policymakers, scholars, and researchers in both public and private institutions. In this thesis, I scrutinize the intellectual property rights debate regarding researchers, public and private institutions, open science, and innovation, and then address a set of correlated questions regarding IPR’s affect and influence on national researchers regarding innovation in (1) their choice of research area and research approach; (2) communication and access to state of the art technology; (3) future research; and (4) disclosure. Norwegian national institutes will be the foundation for my research. To address the questions I create an online survey that will be used to find trends among the researchers, and augment the survey results with interviews to get a deeper understanding behind the reasons for these trends. I find that Norwegian national researchers are affected by IPR, whether it is consciously or unconsciously, but not in a manner that hinders innovation and research in a great amount.

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Meyer, Leonz. "Das selektive Vertriebssystem : seine Berührung mit dem KG, UWG, IPR und dem Europa-Recht /." Bern ;Berlin [u.a.] : Lang, 1993. http://www.gbv.de/dms/spk/sbb/recht/toc/271830697.pdf.

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Schmelzer, Mikael. "Der Konsumentenvertrag : Betrachtung einer obligationenrechtlichen Figur unter Berücksichtigung des IPR und der europäischen Rechtsangleichung /." Chur ;Zürich : Rüegger, 1995. http://www.gbv.de/dms/spk/sbb/recht/toc/272578932.pdf.

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Mesquita, Amir Zacarias. "Investigação experimental da distribuição de temperaturas no reator nuclear de pesquisa TRIGA IPR-R1." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267323.

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Orientador: Elias Basile Tambourgi
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: O Reator Nuclear de Pesquisa TRIGA IPR-RI completou em novembro de 2004, 44 anos de operação. Inicialmente sua potência máxima era de 30 kW térmicos, posteriormente acrescentaram-se mais elementos combustíveis ao núcleo aumentando a potência para 100 kW, sendo esta a atual potência licenciada. Novos combustíveis foram acrescentados recentemente permitindo que a potência atinja níveis de 250 kW. O TRIGA IPR-RI é um reator de piscina com o núcleo refrigerado por circulação natural. Apesar dos vários trabalhos de pesquisa realizados nesta instalação, notadamente em ativação neutrônica, existe uma carência de dados termo-hidráulicos teóricos e experimentais sobre seu funcionamento. Sendo assim rea1izou-se-se uma série de testes experimentais dando enfoque a medidas de temperatura no centro do elemento combustível, no núcleo e no poço, com o reator operando em vários níveis de potência. As experiências aqui relatadas fazem parte da programação de pesquisas do CDTN/CNEN, que têm como objetivo comissionar o Reator TRIGA IPR-RI para a operação rotineira a 250 kW. Este trabalho descreve os estudos analíticos e experimentais realizados com o intuito de determinar a distribuição das temperaturas no reator. Desenvolveu-se uma metodologia para a calibração e monitoração da potência dissipada pelo núcleo, implantando assim novos canais de medida de potência por processo térmico. A condutividade térmica do elemento combustível e o coeficiente de transferência de calor de seu revestimento para o refrigerante foram avaliados experimentalmente. Foi proposta uma formulação para a determinação do valor da condu1ância na interface entre combustível e seu revestimento (gap). Os resultados experimentais foram comparados com valores teóricos encontrados na literatura. Como subsídio às experiências, desenvolveu-se um sistema e um programa de coleta e processamento de dados para o reator, capaz de acompanhar em tempo real e registrar seus - principais parâmetros operacionais. As experiências realizadas permitiram uma melhor compreensão do comportamento termofluidodinâmico do reator, ajudando no aperfeiçoamento de sua modelagem e contribuindo para a sua segurança operacional
Abstract: The TRIGA-IPR-R1 Research Nuclear Reactor has completed 44 years in operation in November 2004. Its initial nominal thermal power was 30 kW. In 1979 its power was increased to 100 kW by adding new fuel elements to the reactor. Recently some more fuel elements were added to the core increasing the power to 250 kW. The TRIGA-IPR-R1 is a pool type reactor with a natural circulation core cooling system. Although the large number of experiments had been carried out with this reactor, mainly on neutron activation analysis, there is not many data on its thermal-hydraulics processes, whether experimental or theoretical 80 a number of experiments were carried out with the measurement of the temperature inside the fuel element, in the reactor core and along the reactor pool. During these experiments the reactor was set in many different power levels. These experiments are part of the CDTN/CNEN research program, and have the main objective of commissioning the 1RIGA-IPR-Rl reactor for routine operation at 250 kW. This work presents the experimental and theoretical analyses to determine the temperature distribution in the reactor. A methodology for the calibration and monitoring the reactor thermal power was also developed. This methodology allowed adding others power measuring channels to 1he reactor by using thermal processes. The fuel thermal conductivity and the heat transfer coefficient from the cladding to the coolant were also experimentatly valued. It was also presented a correlation for the gap conductance between the fuel and the cladding. The experimental results were compared with theoretical calculations and with data obtained from technical literature. A data acquisition and processing system and a software were developed to help the investigation. This system allows on line monitoring and registration of the main reactor operational parameters. The experiments have given better comprehension of the reactor thermal-fluid - dynamics and helped to develop numerical models, contributing to operational safety improvements
Doutorado
Sistemas de Processos Quimicos e Informatica
Doutor em Engenharia Química

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Vio, Carrasco Jaime Andrés. "La estrategia de ejecución de proyectos IPD (Integrated Project Delivery)situación actual y tendencias." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/145241.

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Ingeniero Civil
Las estrategias de ejecución de proyectos corresponden a la forma en el cual el mandante materializa las fases de Ingeniería y Construcción de su proyecto, estableciendo a las diferentes empresas participantes, en qué momento se incorporan éstas al proyecto, cómo se distribuyen las responsabilidades, entre otros aspectos. Todo lo definido en este proceso se establece en los contratos entre el dueño de proyecto y las diferentes empresas de Ingeniería y Construcción. Uno de los principales problemas que evidencian las estrategias tradicionales de ejecución de proyectos, es que en general se desarrollan bajo un ambiente donde cada empresa participante busca obtener los mayores beneficios con el menor esfuerzo posible, en una estructura jerárquica vertical (mandante-diseñadores-constructores) donde cada actor se aboca al desarrollo del trabajo propio involucrándose escasamente con otras especialidades. La estrategia de ejecución de proyectos conocida como Integrated Project Delivery (IPD), presentada en el año 2007, por The American Institute of Architects (AIA) busca dar solución a los principales problemas que generan las estrategias de ejecución comúnmente utilizadas (DB, DBB, EPC, EPCM y CMc). La estrategia IPD se caracteriza por involucrar tempranamente a los principales actores en fases de diseño del proyecto en un ambiente de cooperación, innovación y coordinación enfocándose en optimizar los recursos, procesos y actividades para finalizar en forma eficaz el proyecto. El objetivo principal de esta memoria es analizar la situación actual y tendencias de la estrategia IPD en proyectos. Para contextualizar al lector, se realiza un estudio sobre las estrategias tradicionales de ejecución de proyectos, y en particular sobre la estrategia IPD, para entender su aplicación en cada una de las fases del ciclo de vida del proyecto. Se entrevistan a profesionales expertos en la materia para obtener información acerca de los procesos de definición de las estrategias de ejecución y para saber si la estrategia IPD podría ser aplicable en proyectos que se desarrollan en Chile, en particular, si la cultura de las empresas favorece la implementación de los principios y aspectos contractuales que establece la estrategia IPD. Una de las principales conclusiones obtenidas en esta memoria, es que no existiría una mejor estrategia de ejecución, todas muestran ventajas y desventajas ante ciertos escenarios. La estrategia IPD posee características y principios que aumentan las probabilidades de éxito y de obtención de mejores soluciones tanto de diseño como constructivas. Sin embargo, en relación a su implementación, se debe reconocer que se requiere un importante cambio cultural en las organizaciones para poder establecer contratos acordes con estas características, algo que en el corto plazo parece difícil y que en la actualidad solo algunas empresas y dueños podrían llevar a cabo con éxito.

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NASCIMENTO, Samira Ruana Vidal do. "Implementação de uma montagem experimental em escala reduzida para análise da dispersão de boro em um pressurizador de um reator modular compacto e integral." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17903.

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CAPES
Os Small Modular Reactors, SMRs, são reatores modulares compactos variantes dos reatores de geração III+ que apresentam características atrativas, como a simplicidade, maior segurança e são economicamente competitivos. Atualmente, há muitos projetos de SMRs com características estruturais distintas, como potência, tipo de combustível e frequência de abastecimento. O SMR em estudo é um reator do tipo PWR (reator de água pressurizada) que possui o sistema integrado (iPWR). Esse sistema é caracterizado pela inclusão de todo o sistema primário dentro do vaso de pressão, incluindo o gerador de vapor e o pressurizador. Em um iPWR, o pressurizador está localizado no topo do vaso do reator; esta configuração envolve mudanças técnicas como, por exemplo, alteração no mecanismo de circulação adotado para a homogeneização das concentrações de Boro. Assim, o presente trabalho representa uma contribuição para a concepção de uma instalação experimental planejada para fornecer dados relevantes para estudar os fenômenos de homogeneização de Boro no pressurizador de um reator modular compacto. Para isso, foi montada uma instalação experimental com uma seção de teste em aço inoxidável com escala de 1:200, referente a ¼ do pressurizador de um iPWR. Trabalhos anteriores determinaram os principais parâmetros para a construção de um modelo em escala reduzida para análise de dispersão de Boro no pressurizador de um reator com a configuração integral. Esses parâmetros, como medidas dos orifícios e vazão de circulação, foram a base para a execução do projeto referente a montagem experimental. Além da seção de teste, a instalação experimental dispõe de duas bombas rotativas, 5 medidores de vazão e 3 tanques em aço inoxidável, com capacidades de, aproximadamente, 70, 143 e 216 litros. A montagem foi realizada de modo que a seção de teste fosse alimentada com água ou com uma solução com concentração diferente, representando cenários de boração ou deboração. Para determinar a concentração na entrada e na saída da seção de teste, foram realizadas coletas de amostras, a cada 10 minutos, durante os experimentos que representavam alguns cenários (boração/deboração). Utilizando um condutivímetro de bancada, a condutividade elétrica dessas amostras foi determinada e convertida em concentração do elemento traço utilizado. Após a montagem, com as devidas instalações, testes de operação e execução dos experimentos, foi possível comprovar a viabilidade de empregar a montagem experimental, de maneira confiável, para obter valores que possam analisar o fenômeno de homogeneização de Boro em um pressurizador de um reator modular compacto.
The Small Modular Reactors, SMRs, are compact variants modular reactors of generation III + reactors that feature attractive features such as simplicity, enhanced security and are economically competitive. Currently, there are many SMRs projects with distinct structural characteristics such as power, fuel type and supply frequency. The SMR in the study, is a PWR (pressurized water reactor) reactor type that integrated (iPWR). This system is characterized by the inclusion of the entire primary system inside the pressure vessel, including a steam generator and the pressurizer. In one iPWR, the pressurizer is located at the top of the reactor vessel; this configuration change involves techniques such as, for example, change in the movement mechanism adopted for the mixing of boron concentrations. The present work is a contribution to the design of an experimental installation designed to provide relevant data to study the boron homogenization phenomena pressurizer in a compact modular reactor. For this, we assembled an experimental installation with a test section in stainless steel with scale of 1:200, referring to ¼ of the pressurizer of a iPWR. Previous work has determined the key parameters for the construction of a small-scale model for analysis boron dispersion in a reactor pressurizer with the full configuration. These parameters, such as measures of circulation orifices and flow were the basis for the implementation of the design related to the experimental setup. In the test section, the experimental apparatus has two rotary pumps, 5 flow meters and 3 stainless steel tanks with capacities of approximately 70, 143 and 216 liters. The fitting was performed so that the test section was fed with water or a solution with different concentration, or boration scenarios representing deboration. To determine the concentration at the inlet and outlet of the test section, samples have been collected every 10 minutes during the experiments representing some scenarios (boration/deboration). Using a benchtop conductivity, the electrical conductivity of these samples was determined and converted to the concentration of the trace element used. After assembly, with the operation testing and execution of experiments, it was possible to prove the viability of using the experimental setup, reliably, for values that can analyze the boron homogenization phenomenon in a pressurizer of a compact modular reactor.

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47

Makhani, Kiran, and Kiran Makhani. "Mechanism of Action of ERBB Decoy Cancer Therapeutic Peptide SAH5." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626139.

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Breast cancer is the most prevalent type of cancer and second leading cause of death in women. Among others, the triple negative breast cancer (TNBC) is the most invasive as it has the highest recurrence and death rates with no targeted therapeutic available thus far. Epidermal Growth Factor Receptor (EGFR) is one of the important targets as more than fifty percent of the TNBC overexpress it but all the therapies designed against it have failed to show significant results. The juxtamembrane domain of EGFR has been explored comparatively recently and has been used to design a decoy peptide with the anticipation to affect the EGFR downstream functions. Previous research has shown it to cause cell death in cancer cells. This study is aimed towards deciphering the mechanism of action of the stapled form of this decoy peptide-SAH5. It presents evidence that the peptide leads to an immediate intracellular calcium release from the Inositol 1,4,5 triphosphate on the endoplasmic reticulum, an inhibition of which can rescue SAH5 induced cell death. The study also demonstrate that the peptide is able to increase the production of Reactive Oxygen Species (ROS) in mitochondria, part of which is triggered by the peptide-induced calcium release.

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48

Andersson, Marie. "Piraterna i Mittens Rike : Hur kan svenska företag i Kina skydda sig mot piratkopiering?" Thesis, University of Kalmar, Baltic Business School, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-412.

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OECD uppger att handeln med piratkopierade varor uppgick till 200 miljarder USD under bara år 2005, samtidigt menar de att den verkliga siffran troligtvis är betydligt högre. Asien bedöms av OECD vara den största källan till piratkopierade varor, och Kina är världsetta. Samtidigt ökar antalet svenska företag i Kina explosionsartat. Under 2007 etablerades ett svenskt företag var fjärde dag i Kina.

Syftet med uppsatsen är att analysera hur svenska företag i Kina kan skydda sig mot piratkopiering. Syftet är således även att diskutera de olika möjligheter och hinder företagen står inför.

Uppsatsen är hermeneutiskt skriven med ett kvalitativt angreppssätt. Uppsatsen grundar sig dels på en litteraturstudie, dels på egna primärkällor. Primärkällorna består av fem intervjuer med personer verksamma i Shanghai med olika kopplingar till piratkopiering samt en enkätstudie riktad till svenska företag i Kina.

Uppsatsen är starkt influerad av contingency theory (situationsteorin) som menar att hur företag bäst organiserar sig beror på hur företaget och klimatet det verkar i ser ut. Således angrips problemet genom att beskriva hur olika lands- och företagsspecifika faktorer inverkar på de svenska företagens förmåga att hantera piratkopiering. För att beskriva hur företagens olika mellanhavanden med exempelvis leverantörer och anställda inverkar på problemet kompletteras contingency theory med intressentmodellen.

Det kommer att ta lång tid innan svenska företag kan åtnjuta samma juridiska skydd i Kina som Sverige idag erbjuder. Den kinesiska regeringen är åtminstone utåt sett lyhörd och välvilligt inställd, det som hindrar är bland annat protektionism, mutor och korruption. I takt med att kinesiska företag blir mer medvetna om skydd av immateriella rättigheter och antalet kinesiska patentansökningar ökar finns det mycket som talar för att utvecklingen går åt rätt håll. I väntan på att det rättsliga systemet utvecklas är det av stor vikt att de svenska företagen själva vidtar egna åtgärder. Möjligheterna ser olika ut för olika företag. Det är därför centralt att företagen analyserar situationen och utvecklar en piratkopieringsstrategi anpassat just efter deras företag.

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49

Louise, Kollberg. "BIM vid installationsprojektering." Thesis, Linköping University, Department of Science and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19379.

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50

Niemi, Anton, and Stefan Johansson. "Integrated Project Delivery." Thesis, Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-75047.

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Dissertations / Theses on the topic 'IPDR'

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