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Journal articles on the topic 'IPTp-SP'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Orish, Verner N., Prince N. Puplampu, Sylvester Y. Lokpo, et al. "Assessing nursing mothers’ knowledge, perceptions and uptake of Sulphadoxine Pyrimethamine (IPTp-SP) during pregnancy in the Ho Teaching Hospital of the Volta Region of Ghana." PLOS Global Public Health 3, no. 2 (2023): e0000904. http://dx.doi.org/10.1371/journal.pgph.0000904.

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Intermittent preventive therapy during pregnancy with Sulphadoxine Pyrimethamine (IPTp-SP) is one of the potent strategies for preventing malaria in pregnancy (MiP). Factors such as the pregnant woman’s knowledge and very importantly perception or belief about IPTp-SP remains key determinant of IPTp-SP uptake. This study assessed the knowledge and perception of nursing mothers and their uptake of IPTp-SP during pregnancy in the Ho Teaching Hospital. We administered a close-ended questionnaire to 303 nursing mothers and obtained their sociodemographic details as well as information on their kno

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Zhang, Karen, Di Liang, Donglan Zhang, Jun Cao, and Jiayan Huang. "Were Women Staying on Track with Intermittent Preventive Treatment for Malaria in Antenatal Care Settings? A Cross-Sectional Study in Senegal." International Journal of Environmental Research and Public Health 19, no. 19 (2022): 12866. http://dx.doi.org/10.3390/ijerph191912866.

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A significant gap exists between high rates of antenatal care attendance and low uptake of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) in Senegal. This study aims to investigate whether IPTp-SP is delivered per Senegal’s national guidelines and to identify factors affecting the delivery of IPTp-SP at antenatal care visits. A secondary analysis was conducted using the 2014 and 2016 Senegal’s Service Provision Assessment. The study sample consists of 1076 antenatal care across 369 health facilities. Multiple logit regression models were used to estimat

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Buh, Amos, Komlan Kota, Ghose Bishwajit, and Sanni Yaya. "Prevalence and Associated Factors of Taking Intermittent Preventive Treatment in Pregnancy in Sierra Leone." Tropical Medicine and Infectious Disease 4, no. 1 (2019): 32. http://dx.doi.org/10.3390/tropicalmed4010032.

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Malaria infection during pregnancy is a major public health problem in sub-Saharan Africa. The World Health Organization (WHO) recommends that gestational and congenital malaria can be prevented by using intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). IPTp-SP is a full therapeutic course of antimalarial medicine administered during pregnancy as a component of antenatal care. This study’s objective was to assess the prevalence and predictors of IPTp-SP uptake in pregnancy in Sierra Leone. This study was based on the fifth round of the Multiple

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Kalu, Godwin Okeke, Joel Msafiri Francis, Latifat Ibisomi, Tobias Chirwa, and Juliana Kagura. "Factors associated with the uptake of Intermittent Preventive Treatment (IPTp-SP) for malaria in pregnancy: Further analysis of the 2018 Nigeria Demographic and Health Survey." PLOS Global Public Health 3, no. 2 (2023): e0000771. http://dx.doi.org/10.1371/journal.pgph.0000771.

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Pregnancy-associated malaria is preventable and curable with intermittent preventive treatment with Sulfodoxine-Pyrimethamine (IPTp-SP). However, despite the effectiveness of IPTp-SP against malaria in pregnancy, the uptake among pregnant women in Nigeria remains very low. Thus, this study aimed to establish the factors associated with the uptake of at least one dose and optimal doses of IPTp-SP among pregnant women aged 15 to 49 years living in Nigeria in 2018. The study included 12,742 women aged 15 to 49 years with live births two years before or during the 2018 Nigeria Demographic Health S

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Natuhamya, Charles, Edson Mwebesa, and Nazarius Mbona Tumwesigye. "Effect of knowledge of sulfadoxine-pyrimethamine (SP) as prophylaxis for malaria on its uptake for intermittent preventive treatment of malaria in pregnancy (IPTp): Application of inverse probability weighted regression adjustment (IPWRA) technique." PLOS ONE 20, no. 4 (2025): e0320893. https://doi.org/10.1371/journal.pone.0320893.

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Introduction Malaria still remains a global health issue. In response, the World Health Organisation has continuously recommended the use of Sulfadoxine-Pyrimethamine (SP) for Intermittent Preventive Treatment of Malaria in Pregnancy (IPTp) as a malaria preventive measure for the mother and fetus, which has been implemented by the Ugandan government. In collaboration with partners, the government has created awareness of using SP for IPTp (SP-IPTp) among women mainly through media. Studies have investigated the effect of a woman’s education attainment on SP-IPTp. However, the effect of knowled

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6

Oppong, Felix Boakye, Stephaney Gyaase, Charles Zandoh, et al. "Intermittent preventive treatment of pregnant women in Kintampo area of Ghana with sulphadoxine-pyrimethamine (SP): trends spanning 2011 and 2015." BMJ Open 9, no. 6 (2019): e027946. http://dx.doi.org/10.1136/bmjopen-2018-027946.

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ObjectiveIn Ghana, intermittent preventive treatment during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) is recommended for the prevention of malaria-related adverse outcomes. This study demonstrates the coverage of IPTp-SP use among pregnant women over a period (2011–2015) and the impact of various sociodemographic groups on the uptake of IPTp-SP.DesignRetrospective analysis using data from all pregnant women in the Kintampo Health and Demographic Surveillance System area on the uptake of IPTp-SP.SettingKintampo North Municipality and Kintampo South District of Ghana.ParticipantsAll pr

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Berchie, Gifty Osei, Patience Fakornam Doe, Theodora Dedo Azu, et al. "Uptake and Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine during Pregnancy in Africa: A Scoping Review." Diseases 12, no. 9 (2024): 203. http://dx.doi.org/10.3390/diseases12090203.

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Malaria poses a significant threat to pregnant women in sub-Saharan Africa, necessitating effective interventions like the intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, challenges persist in the uptake and effectiveness of this intervention. This scoping review aims to explore IPTp-SP uptake in African countries, identify influencing factors, and assess its effectiveness in preventing malaria and adverse outcomes in pregnancy. This scoping review follows Arksey and O’Malley’s framework, employing the PRISMA-ScR guidelines for repor

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Ameyaw, Edward Kwabena, Carolyne Njue, Roberta Mensima Amoah, et al. "Is improvement in indicators of women’s empowerment associated with uptake of WHO recommended IPTp-SP levels in sub-Saharan Africa? A multilevel approach." BMJ Open 11, no. 10 (2021): e047606. http://dx.doi.org/10.1136/bmjopen-2020-047606.

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ObjectivesThe global burden of malaria has reduced considerably; however, malaria in pregnancy remains a major public health problem in sub-Saharan Africa (SSA), where about 32 million pregnant women are at risk of acquiring malaria. The WHO has recommended that pregnant women in high malaria transmission locations, including SSA, have intermittent preventive treatment of malaria during pregnancy with at least three doses of sulphadoxine-pyrimethamine (IPTp-SP). Therefore, we investigated the prevalence of IPTp-SP uptake and associated individual-level, community-level and country-level predic

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Asem, Livingstone, Abdul-Gafaru Abdulia, Patrick Opoku Assuming, and Gordon Abeka-Nkrumah. "The demand for intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine in the Volta Region of Ghana." PLOS ONE 19, no. 9 (2024): e0308321. http://dx.doi.org/10.1371/journal.pone.0308321.

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Background Malaria in pregnancy (MiP) is a preventable condition leading to maternal and neonatal morbidity and mortality. Invariably, with all the knowledge about the serious consequences of MiP for the woman, the unborn child, and the neonate, the uptake of Intermittent Preventive Treatment of Malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) is low in most malaria-endemic countries, including Ghana. This study sought to examine the uptake and service user predictors of the implementation of IPTp-SP after the policy upgrade in 2014. Methods This cross-sectional survey was carrie

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Ogba, Patricia, Andrea Baumann, Tunde Alabi, et al. "Enhancing IPTp-SP uptake: Community and stakeholder recommendations for improving access and utilisation – insights from a study in Bayelsa-Nigeria." MalariaWorld Journal 16, no. 9 (2025): 1–14. https://doi.org/10.5281/zenodo.15351243.

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<strong>Background. </strong>Malaria remains a major global health challenge, disproportionately affecting pregnant women and children. In Nigeria, malaria in pregnancy contributes to 70.5% of maternal morbidity and 41.1% of maternal mortality. Recognising these risks, the World Health Organization recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) as a key strategy for malaria in pregnancy prevention. However, despite its proven effectiveness, pregnant women’s uptake of IPTp-SP remains unacceptably low. This study presents participant-driven recommenda

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Patricia, Ogba, Baumann Andrea, Chidwick Hanna, Banfield Laura, and D. DiLiberto Deborah. "Barriers and facilitators to access and uptake of intermittent preventive treatment with sulfadoxine-pyrimethamine among pregnant women in Nigeria: a scoping review." MalariaWorld Journal 13, no. 4 (2022): 1–18. https://doi.org/10.5281/zenodo.8205236.

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Malaria in pregnancy is a significant public health concern in Nigeria. It threatens pregnant women and their unborn babies and undermines the achievement of Sustainable Development Goal 3. The World Health Organization has recommended intermittent preventive treatment with sulfadoxine-pyrimethamine [IPTp-SP] for its control, but there are challenges to its access and uptake. Using the Arksey and O'Malley framework and the cascade of care model, we conducted a scoping review to investigate barriers and facilitators of IPTp-SP access and uptake, including their influence on pregnant wo

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Agyeman, Yaa Nyarko, Sam Kofi Newton, Raymond Boadu Annor, and Ellis Owusu-Dabo. "The Effectiveness of the Revised Intermittent Preventive Treatment with Sulphadoxine Pyrimethamine (IPTp-SP) in the Prevention of Malaria among Pregnant Women in Northern Ghana." Journal of Tropical Medicine 2020 (November 23, 2020): 1–9. http://dx.doi.org/10.1155/2020/2325304.

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This study investigated the effectiveness of the World Health Organization (WHO)-revised Intermittent Preventive Treatment using Sulphadoxine Pyrimethamine (IPTp-SP) dosage regimen in the prevention of malaria infections in pregnancy. The study involved a prospective cohort of pregnant women who attended the antenatal clinic in four health facilities (Tamale Teaching Hospital, Tamale West Hospital, Tamale Central Hospital, and Tamale SDA Hospital) within the Tamale metropolis. Data collection spanned a period of 12 months, from September 2016 to August 2017, to help account for seasonality in

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Sinyange, Danny, Nawa Mukumbuta, Lwito Salifya Mutale, Hudson Mumbole, Busiku Hamainza, and Cephas Sialubanje. "Uptake of four or more doses of sulfadoxine pyrimethamine for intermittent preventive treatment of malaria during pregnancy in Zambia: findings from the 2018 malaria in pregnancy survey." BMJ Open 13, no. 5 (2023): e073287. http://dx.doi.org/10.1136/bmjopen-2023-073287.

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ObjectiveTo determine the prevalence and predictors of the uptake of four or more doses of sulfadoxine pyrimethamine (IPTp-SP 4+) in Zambia.DesignA cross-sectional study using secondary data from the malaria in pregnancy survey (Malaria Indicator Survey) data set conducted from April to May 2018.SettingThe primary survey was conducted at community level and covered all the 10 provinces of Zambia.ParticipantsA total of 3686 women of reproductive age (15–45 years) who gave birth within the 5 years before the survey.Primary outcomeProportion of participants with four or more doses of IPTp-SP.Stat

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Eboumbou Moukoko, Carole Else, Loick Pradel Kojom Foko, Angèle Ayina, et al. "Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Pfdhfr-Pfdhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon." Pathogens 12, no. 6 (2023): 844. http://dx.doi.org/10.3390/pathogens12060844.

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Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impact on maternal infection and birth outcomes in the context of widespread SP resistance in the city of Douala, Cameroon. Clinical and demographic information were documented among 888 pregnant women attending 3 health facilities, from the antenatal care visit to delivery. Positive samples were genotyped for P. falciparum gene (dhfr, dhps, and k13) mu

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Godwin, Isaac Okezie, Ifeoma Mercy Ekejindu, George Uchenna Eleje, et al. "Effectiveness of antenatal intermittent preventive treatment for malaria with sulphadoxine-pyrimethamine on peripartum outcomes." Therapeutic Advances in Infectious Disease 9 (January 2022): 204993612211226. http://dx.doi.org/10.1177/20499361221122620.

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Background: Following the World Health Organization (WHO) recommendations for 4-weekly antenatal intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine (IPTp-SP), there is a need to evaluate the drug performance in order to determine their effectiveness as tools in malaria control policy. Objectives: To determine prevalence of cord blood malaria, compliance gap and adverse pregnancy outcomes (anaemia, preterm delivery, spontaneous abortion, intra-uterine foetal death and low birth weight) among antenatal IPTp-SP users compared with non-users. Methods: A cros

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A. Asare, Brainard, and Grace Asare. "A health facility-based assessment of the ancillary benefit for prevention of anaemia at term of intermittent preventive therapy with sulfadoxine-pyrimethamine in pregnancy." Ghana Medical Journal 58, no. 4 (2025): 269–78. https://doi.org/10.4314/gmj.v58i4.4.

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Objective: This study aims to evaluate the ancillary benefit of intermittent preventive therapy with sulfadoxine-pyrimethamine ( IPTp-SP) in preventing maternal anaemia (MA) among parturient women differentially exposed to the regimen.Design: A health facility-based retrospective analytical cross-sectional study.Settings: The study was conducted at the Kade Government Hospital’s maternity/labor suit.Participants: Data from 2,545 parturient women were abstracted from birth registers.Statistical analysis: Baseline characteristics were described, and stratified analyses assessed their impacts. Di

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Taylor, Steve M., Brandt Levitt, Betsy Freedman, et al. "Interactions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in Malawi." Journal of Infectious Diseases 222, no. 4 (2020): 661–69. http://dx.doi.org/10.1093/infdis/jiaa145.

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Abstract Background Sulfadoxine-pyrimethamine (SP) is used as intermittent preventive therapy in pregnancy (IPTp) for malaria in sub-Saharan Africa. The resistance marker dhps A581G has been associated with reduced IPTp-SP efficacy and enhanced morbidity in SP recipients. Methods We measured SP-resistance allele frequencies in Malawian women participating in a trial comparing IPTp with SP against intermittent screening by rapid diagnostic tests (ISTp). We genotyped polymerase chain reaction-detected parasites using deep sequencing of SP-resistance alleles. Results Among 125 placental infection

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Aberese-Ako, Matilda, Pascal Magnussen, Gifty D. Ampofo, Margaret Gyapong, Evelyn Ansah, and Harry Tagbor. "An ethnographic study of how health system, socio-cultural and individual factors influence uptake of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a Ghanaian context." PLOS ONE 16, no. 10 (2021): e0257666. http://dx.doi.org/10.1371/journal.pone.0257666.

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Background Intermittent preventive treatment of malaria among pregnant women with sulfadoxine-pyrimethamine (IPTp-SP), is one of the three recommended interventions for the prevention of malaria in pregnancy (MiP) in sub-Sahara Africa. The World Health Organisation recommended in 2012 that SP be given at each scheduled ANC visit except during the first trimester and can be given a dose every month until the time of delivery, to ensure that a high proportion of women receive at least three doses of SP during pregnancy. Despite implementation of this policy, Ghana did not attain the target of 10

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Guimsop, Dominique Ken, Ange Faustine Kenmogne Talla, Haoua Kodji, and Jerome Ateudjieu. "Factors associated with the uptake of intermittent preventive treatment for malaria during pregnancy in Cameroon: An analysis of data from the 2018 Cameroon Demographic and Health Survey." PLOS Global Public Health 4, no. 3 (2024): e0001245. http://dx.doi.org/10.1371/journal.pgph.0001245.

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Malaria in pregnancy is a major public health concern that contributes to a significant increase in maternal and child mortality and morbidity. Intermittent preventive treatment of malaria during pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) is a key intervention recommended by the World Health Organization (WHO) and implemented in Cameroon to reduce the morbidity associated with malaria during pregnancy. This study aimed to assess the distribution of the poor uptake of IPTp-SP (i.e. fewer than three doses) in Cameroon and the factors associated. We conducted a secondary analysis of data

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Odongo, Charles Okot, Michael Odida, Henry Wabinga, Celestino Obua, and Josaphat Byamugisha. "Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala." Malaria Research and Treatment 2016 (December 13, 2016): 1–7. http://dx.doi.org/10.1155/2016/1839795.

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Intermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance, we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls were pregnant women presenting in early labour without history of SP-IPTp. Histopathological investigatio

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Badirou, Aguemon, Damien Barikissou Georgia, Padonou Sètondji Géraud Roméo, Kouwanou Modeste Luc, and Ouendo Edgard Marius. "Adherence to Intermittent Preventive Treatment of Malaria in Pregnancy with Sulfadoxine–Pyrimethamine and Associated Factors: A Cross-Sectional Survey in Benin’s Public Hospitals." Open Public Health Journal 11, no. 1 (2018): 28–36. http://dx.doi.org/10.2174/1874944501811010028.

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Background: Gestational malaria is a public health problem, thus responsible for morbidity and mortality risk to both the foetus and the mother. The intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy (IPTp-SP) is one of the strategies recommended by the WHO to prevent this pathology and its consequences during pregnancy. In Benin, the adherence rate remains below the programmatic targets. This study aimed to identify the factors associated to the adherence to at least two IPTp-SP doses for postpartum women of the University Hospital HKM of Cotonou (CNHU-HKM) and

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Dzameshie, Benjamin, Mabel W. Dzenu, Wotordzor Godson, and Philip Bokorgah. "Impact of Malaria Interventions on Anaemia amongst Pregnant Women in Ghana: A Secondary Analysis of Data." Preventive Medicine: Research & Reviews 1, no. 2 (2023): 102–6. http://dx.doi.org/10.4103/pmrr.pmrr_99_23.

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Abstract Background: There is limited published literature available on the impact of insecticide-treated nets (ITNs) and sulphadoxine-pyrimethamine (Sp) as an intermittent preventive treatment for malaria in pregnancy (IPTp) on anaemia amongst pregnant women in Ghana. Materials and Methods: The data from the United States Agency for International Development Malaria Indicator Survey in Ghana for 2016 and 2019 was used and analysed. Key variables, including anaemia status, ITN usage and IPTp-Sp uptake, were analysed using descriptive statistics, Chi-square and logistic regression. Results: The

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Mlugu, Eulambius M., Omary Minzi, Muhammad Asghar, Anna Färnert, Appolinary A. R. Kamuhabwa, and Eleni Aklillu. "Effectiveness of Sulfadoxine–Pyrimethamine for Intermittent Preventive Treatment of Malaria and Adverse Birth Outcomes in Pregnant Women." Pathogens 9, no. 3 (2020): 207. http://dx.doi.org/10.3390/pathogens9030207.

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Effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) for prevention of malaria and adverse birth outcomes can be compromised by parasites-resistance to sulfadoxine–pyrimethamine. This study prospectively evaluated the effectiveness of IPTp-SP in Southeast Tanzania. From January 2017 to May 2019, HIV-negative and malaria-negative (mRDT) pregnant women attending their first antenatal-care visit in the second or third trimester (n = 500) were enrolled to receive monthly IPTp-SP and followed the protocol till delivery. The primary outcome was the

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Kanobere, Harbart. "Enhancing IPTp Program Implementation: Provider Practices, Challenges, and Malaria Prevalence among Pregnant Women in Uganda." IDOSR JOURNAL OF SCIENCE AND TECHNOLOGY 10, no. 1 (2024): 43–50. http://dx.doi.org/10.59298/idosr/jst/24/101.234350.

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Malaria remains a formidable public health threat, particularly in sub-Saharan Africa, where pregnant women face heightened vulnerability. Intermittent Preventive Treatment in pregnancy with Sulfadoxine Pyrimethamine (IPTp-SP) stands as a pivotal strategy in malaria prevention efforts. However, its full potential is hindered by challenges in implementation. This study, conducted at Bushenyi Health Centre IV in Uganda, scrutinized provider practices, challenges encountered, and malaria prevalence among pregnant women attending antenatal care services. Through a descriptive cross-sectional appro

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Igboeli, Nneka U., Chinwe V. Ukwe, and Cletus N. Aguwa. "Effect of antimalarial prophylaxis with sulphadoxine-pyrimethamine on pregnancy outcomes in Nsukka, Nigeria." MalariaWorld Journal 8, no. 3 (2017): 1–5. https://doi.org/10.5281/zenodo.10757166.

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<strong>Background.</strong> We evaluated the association between the use of intermittent preventive treatment with sulphadoxinepyrimethamine (IPTp-SP) on pregnancy outcomes among women who delivered at a secondary hospital in Nsukka, Enugu State, Nigeria. <strong>Materials and methods.</strong> Relevant obstetric data (e.g. IPTp-SP use), matched against pregnancy outcome data such as delivery method, stillbirth, maternal haematocrit test results and babies’ birth weights, were collected retrospectively from antenatal care (ANC) case files of women who delivered within a one-year period

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Benjamin, Afaayo. "Assessment of Implementation of Malaria Control Strategies among Pregnant Mothers Attending Antenatal Care at Bumanya Health Centre IV in Kaliro District." IAA Journal of Biological Sciences 12, no. 1 (2024): 20–31. http://dx.doi.org/10.59298/iaajb/2024/121.2031.11.

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Although a high proportion of pregnant women had an antenatal care (ANC) visit at least once during pregnancy, the coverage level of intermittent preventive treatment of malaria in pregnancy (IPTp-SP) and insecticide-treated bednets (ITNs) remains low in Sub-Saharan Africa. A hospital-based descriptive cross-sectional study was carried out. The outcome of the survey revealed that the majority of participants, 79%, were above 20 years old, with a mean (+/-SD) age of 25.6 (+/-SD) years. The survey also revealed that 62.67% of the participants knew about IPTp; the biggest number of participants (

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Loyce, Natukwasa. "Assessing the Impact of Intermittent Preventive Treatment in Reducing Malaria Incidence among Pregnant Women in High-Risk Areas." RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES 4, no. 2 (2024): 56–59. https://doi.org/10.59298/rijbas/2024/425659.

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Malaria poses significant health risks for pregnant women, especially in high-transmission areas such as sub-Saharan Africa. Physiological and immunological changes during pregnancy increase vulnerability to malaria-related complications, including maternal anemia, low birth weight, and preterm delivery, which can severely impact maternal and neonatal health. To combat these risks, the World Health Organization (WHO) recommended Intermittent Preventive Treatment in Pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) as a proactive measure to reduce malaria incidence in this population. IPTp-S

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Olaleye, Atinuke, Noblefather Uyaiabasi, Charles Elikwu, and Oladapo Walker. "PO 8502 DETERMINANTS AND PREVALENCE OF PARASITE RESISTANCE AMONG PREGNANT WOMEN RECEIVING IPTP WITH SULPHADOXINE-PYRIMETHAMINE IN NIGERIA." BMJ Global Health 4, Suppl 3 (2019): A46.3—A47. http://dx.doi.org/10.1136/bmjgh-2019-edc.122.

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BackgroundMalaria in pregnancy carries a risk of significant adverse maternal and infant outcomes. Intermittent preventive treatment in pregnancy (IPTp) is advocated to reduce its occurrence, but resistance to sulphadoxine-pyrimethamine (SP) is being reported. This study aims to describe the burden of SP resistance and determinants of its occurrence among pregnant women receiving IPTp in Nigeria.MethodsA prospective observational study is to be conducted in Ogun State over 24 months. Pregnant women 16–28 weeks gestation meeting the eligibility criteria are being enrolled; blood samples are tak

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Figueroa-Romero, Antia, Clara Pons-Duran, and Raquel Gonzalez. "Drugs for Intermittent Preventive Treatment of Malaria in Pregnancy: Current Knowledge and Way Forward." Tropical Medicine and Infectious Disease 7, no. 8 (2022): 152. http://dx.doi.org/10.3390/tropicalmed7080152.

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Malaria infection during pregnancy is an important driver of maternal and neonatal health in endemic countries. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention at each scheduled antenatal care visit, starting at the second trimester, in areas of high and moderate transmission. However, the increased resistance to SP in some endemic areas challenges its effectiveness. Furthermore, SP is contraindicated in the first trimester of pregnancy and in HIV-infected women on co-trimoxazole prophylaxis due to potential drug–d

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Cirera, Laia, Charfudin Sacoor, Martin Meremikwu, et al. "Cost-effectiveness of community-based distribution of intermittent preventive treatment of malaria in pregnancy in Madagascar, Mozambique, Nigeria, and the Democratic Republic of Congo." BMJ Global Health 8, no. 7 (2023): e010238. http://dx.doi.org/10.1136/bmjgh-2022-010238.

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IntroductionMalaria in pregnancy is a major driver of maternal and infant mortality in sub-Saharan Africa. The WHO recommends the administration of intermittent preventive treatment with sulfadoxine pyrimethamine (IPTp-SP) at antenatal care (ANC) visits. Despite being a highly cost-effective strategy, IPTp-SP coverage and uptake remains low. A pilot project was conducted to assess the cost-effectiveness (CE) of community-based delivery of IPTp (C-IPTp) in addition to ANC delivery to increase IPTp uptake in the Democratic Republic of Congo (DRC), Madagascar (MDG), Mozambique (MOZ) and Nigeria (

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Ruizendaal, Esmée, Marc C. Tahita, Ronald B. Geskus, et al. "Increase in the prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso." Malaria Journal 16, no. 1 (2017): 179. https://doi.org/10.1186/s12936-017-1831-y.

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<strong>Background: </strong>Pregnant women are a high-risk group for <i>Plasmodium falciparum</i> infections, which may result in maternal anaemia and low birth weight newborns, among other adverse birth outcomes. Intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy (IPTp-SP) is widely implemented to prevent these negative effects of malaria. However, resistance against SP by <i>P. falciparum</i> may decrease efficacy of IPTp-SP. Combinations of point mutations in the <i>dhps</i> (codons A437, K540) and <i>dhfr</i> genes (codons N51, C59, S108) of <i>P. falciparum

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Addai-Mensah, Otchere, Max Efui Annani-Akollor, Linda Ahenkorah Fondjo, et al. "Regular Antenatal Attendance and Education Influence the Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study at the University Hospital, Kumasi, Ghana." Journal of Tropical Medicine 2018 (December 4, 2018): 1–8. http://dx.doi.org/10.1155/2018/5019215.

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Background. The World Health Organization (WHO) recommends the use of Insecticide Treated Bed-Nets and Intermittent Preventive Treatment (IPT) with Sulphadoxine-Pyrimethamine (SP) as interventions in curbing malaria during pregnancy. However, increasing evidence shows a gap in coverage where not all pregnant women receive the recommended SP dose. This study evaluated the factors influencing uptake of IPTp-SP among pregnant women in Kumasi, Ghana. Methodology. This cross-sectional study was conducted among 280 pregnant women attending the Kwame Nkrumah University of Science and Technology Hospi

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Igboeli, Nneka U., Maxwell O. Adibe, Chinwe V. Ukwe, and Nze C. Aguwa. "Prevalence of Low Birth Weight before and after Policy Change to IPTp-SP in Two Selected Hospitals in Southern Nigeria: Eleven-Year Retrospective Analyses." BioMed Research International 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/4658106.

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Background. In 2005, Nigeria changed its policy on prevention of malaria in pregnancy to intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP). Indicators of impact of effective prevention and control of malaria on pregnancy (MIP) are low birth weight (LBW) and maternal anaemia by parity. This study determined the prevalence of LBW for different gravidity groups during periods of pre- and postpolicy change to IPTp-SP. Methods. Eleven-year data were abstracted from the delivery registers of two hospitals. Study outcomes calculated for both pre- (2000–2004) and post-IPTp-SP

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J. Masoi, Theresia, Fabiola V. Moshi, and Maximilian B. Tungaraza. "Factors Associated with Uptake of Intermittent Preventive Treatment for Malaria During Pregnancy. Analysis of Data from the Tanzania 2015-2016 Demographic Health Survey and Malaria Indicator Survey." East African Health Research Journal 6, no. 2 (2022): 134–40. http://dx.doi.org/10.24248/eahrj.v6i2.692.

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Background: Malaria is a life-threatening disease caused by parasites that are transmitted to people through bites of infected female Anopheles mosquitoes. Africa is the home to over 90% of malaria burden when compared to other regions of the world. The region is estimated to have a dominance of 94% of maternal deaths occurring in the world. The purpose of this study was to identify factors associated with the uptake of IPTp-SP among pregnant women in Tanzania. Method: The study used data from the 2015-16 Tanzania Demographic and Health Survey and Malaria Indicators Survey (2015-16 TDHS-MIS).

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Zimbuga M, Kagambira. "Effect of Mobile Health Reminders on Antimalarial Adherence among Pregnant Women in Rural Uganda: A Randomized Controlled Trial." Research Output Journal of Engineering and Scientific Research 4, no. 3 (2025): 55–59. https://doi.org/10.59298/rojesr/2025/4.3.5559.

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Malaria in pregnancy remains a critical public health issue in sub-Saharan Africa, particularly in Uganda, where adherence to intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is persistently low. Poor adherence contributes to adverse maternal and neonatal outcomes, necessitating innovative solutions to enhance antimalarial prophylaxis. Mobile health (mHealth) interventions, such as SMS and voice call reminders, have emerged as promising tools to support treatment adherence in low-resource settings. This review evaluated the effect of mobile health reminders on antimal

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Agyeman, Yaa Nyarko, Sam Newton, Raymond Boadu Annor, and Ellis Owusu-Dabo. "Intermittent preventive treatment comparing two versus three doses of sulphadoxine pyrimethamine (IPTp-SP) in the prevention of anaemia in pregnancy in Ghana: A cross-sectional study." PLOS ONE 16, no. 4 (2021): e0250350. http://dx.doi.org/10.1371/journal.pone.0250350.

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In 2012 the World Health Organisation (WHO) revised the policy on Intermittent Preventive Treatment with Sulphadoxine Pyrimethamine (IPTp-SP) to at least three doses for improved protection against malaria parasitaemia and its associated effects such as anaemia during pregnancy. We assessed the different SP dosage regimen available under the new policy to determine the dose at which women obtained optimal protection against anaemia during pregnancy. A cross-sectional study was conducted among pregnant women who attended antenatal clinic at four different health facilities in Ghana. The registe

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Kiyuka, Patience Kerubo, Mark Muricho, Nelson Ouma, et al. "Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol." Open Research Europe 5 (March 3, 2025): 60. https://doi.org/10.12688/openreseurope.19356.1.

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Introduction Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommends at least three doses of IPTp-SP (IPTp-SP3 +) to pregnant women in regions where malaria is endemic. Although SP remains cost-effective and effective for IPTp, there are two main challenges with the use of SP: i) widespread use of SP can lead to an increase in the prevalence of drug resistance molecular

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Kiyuka, Patience Kerubo, Mark Muricho, Nelson Ouma, et al. "Investigating the dynamics of Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol." Open Research Europe 5 (April 11, 2025): 60. https://doi.org/10.12688/openreseurope.19356.2.

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Introduction Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommends at least three doses of IPTp-SP (IPTp-SP3 +) to pregnant women in regions where malaria is endemic. Although SP remains cost-effective and effective for IPTp, there are two main challenges with the use of SP: i) widespread use of SP can lead to an increase in the prevalence of drug resistance molecular

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Apinjoh, Tobias O., Vincent N. Ntui, Hanesh F. Chi, et al. "Intermittent preventive treatment with Sulphadoxine-Pyrimethamine (IPTp-SP) is associated with protection against sub-microscopic P. falciparum infection in pregnant women during the low transmission dry season in southwestern Cameroon: A Semi - longitudinal study." PLOS ONE 17, no. 9 (2022): e0275370. http://dx.doi.org/10.1371/journal.pone.0275370.

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The current guidelines for malaria prevention and control during pregnancy in Africa is predicated on the prevention of infection and/or disease through intermittent preventive treatment in pregnancy (IPTp), insecticide-treated nets (ITNs) and effective malaria case diagnosis and management. Concerns that increasing SP resistance in some areas of SSA may have compromised IPTp-SP efficacy prompted this contemporaneous study, designed to assess the prevalence and risk factors of sub-microscopic infection in parturient women during the low transmission season in Mutengene, a rapidly growing semi-

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Agomo, Chimere O., Wellington A. Oyibo, and Funke Odukoya-Maije. "Parasitologic Assessment of Two-Dose and Monthly Intermittent Preventive Treatment of Malaria during Pregnancy with Sulphadoxine-Pyrimethamine (IPTP-SP) in Lagos, Nigeria." Malaria Research and Treatment 2011 (October 26, 2011): 1–6. http://dx.doi.org/10.4061/2011/932895.

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Intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine (IPTP-SP) is a key strategy in the control of malaria in pregnancy. However, reports of increasing level of resistance to SP using nonpregnant populations have made it imperative for the continuous monitoring of the efficacy of SP in pregnant women. This study assessed using microscopy, monthly dosing and the standard two-dose regimen among 259 pregnant women attending antenatal clinics in Lagos, Nigeria that consented 122 in the two-dose arm (Arm A) and 137 in the monthly dose arm (Arm B). Baseline parasitaemia in th

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Ayubu, Mdetele B., and Winifrida B. Kidima. "Monitoring Compliance and Acceptability of Intermittent Preventive Treatment of Malaria Using Sulfadoxine Pyrimethamine after Ten Years of Implementation in Tanzania." Malaria Research and Treatment 2017 (March 30, 2017): 1–5. http://dx.doi.org/10.1155/2017/9761289.

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Intermittent preventive treatment using SP (IPTp-SP) is still a superior interventional approach to control malaria during pregnancy. However its rate of use has gone down tremendously in malaria endemic areas. This study forms part of a larger study aimed at monitoring the compliance of IPTp-SP policy in malaria endemic areas of Tanzania. Two cross-sectional studies were conducted in Dar es Salaam and Njombe Regions of Tanzania. Overall, 540 pregnant women and 21 healthcare workers were interviewed using structured questionnaires. This study revealed that 63% of women were not willing to take

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Ramharter, Michael, Matthias Schwab, Ghyslain Mombo-Ngoma, et al. "Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon." Antimicrobial Agents and Chemotherapy 63, no. 2 (2018): e01113-18. http://dx.doi.org/10.1128/aac.01113-18.

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ABSTRACT Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP). This study determined the pharmacokinetic characteristics of the mefloquine stereoisomers and the metabolite carboxymefloquine (CMQ) when given as IPTp in pregnant women. Also, the relationship between plasma concentrations of the three analytes and cord samples was evaluated, and potential covariates influencing the pharmacokinetic properties were assessed. A population pharmacokinetic

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Unger, Holger W., Celestine Aho, Maria Ome-Kaius, et al. "Impact of Intermittent Preventive Treatment in Pregnancy with Azithromycin-Containing Regimens on Maternal Nasopharyngeal Carriage and Antibiotic Sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: a Cross-Sectional Survey at Delivery." Journal of Clinical Microbiology 53, no. 4 (2015): 1317–23. http://dx.doi.org/10.1128/jcm.03570-14.

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Sulfadoxine-pyrimethamine (SP) plus azithromycin (AZ) (SPAZ) has the potential for intermittent preventive treatment of malaria in pregnancy (IPTp), but its use could increase circulation of antibiotic-resistant bacteria associated with severe pediatric infections. We evaluated the effect of monthly SPAZ-IPTp compared to a single course of SP plus chloroquine (SPCQ) on maternal nasopharyngeal carriage and antibiotic susceptibility ofStreptococcus pneumoniae,Haemophilus influenzae, andStaphylococcus aureusat delivery among 854 women participating in a randomized controlled trial in Papua New Gu

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Dosoo, David Kwame, Kezia Malm, Felix Boakye Oppong, et al. "Effectiveness of intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) in Ghana." BMJ Global Health 6, no. 8 (2021): e005877. http://dx.doi.org/10.1136/bmjgh-2021-005877.

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IntroductionGhana adopted the revised WHO recommendation on intermittent preventive treatment in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) in 2012. This study has assessed the effectiveness and safety of this policy in Ghana.MethodsA total of 1926 pregnant women enrolled at antenatal care (ANC) clinics were assessed for birth outcomes at delivery, and placental histology results for malaria infection were obtained from 1642 participants. Association of reduced placental or peripheral malaria, anaemia and low birth weight (LBW) in women who received ≥4 IPTp-SP doses compared with 3 or

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Wallender, Erika, Nan Zhang, Melissa Conrad, et al. "Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda." Antimicrobial Agents and Chemotherapy 63, no. 2 (2018): e01393-18. http://dx.doi.org/10.1128/aac.01393-18.

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ABSTRACT Dihydroartemisinin-piperaquine (DHA-PQ) is under study for intermittent preventive treatment during pregnancy (IPTp), but it may accelerate selection for drug resistance. Understanding the relationships between piperaquine concentration, prevention of parasitemia, and selection for decreased drug sensitivity can inform control policies and optimization of DHA-PQ dosing. Piperaquine concentrations, measures of parasitemia, and Plasmodium falciparum genotypes associated with decreased aminoquinoline sensitivity in Africa (pfmdr1 86Y, pfcrt 76T) were obtained from pregnant Ugandan women

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Amankwah, Selina, and Francis Anto. "Factors Associated with Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study in Private Health Facilities in Tema Metropolis, Ghana." Journal of Tropical Medicine 2019 (August 1, 2019): 1–11. http://dx.doi.org/10.1155/2019/9278432.

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Introduction. Intermittent preventive treatment of malaria in pregnancy with sulfadoxine pyrimethamine (IPTp-SP) is effective in preventing the adverse consequences of malaria on birth outcomes. Methods. A cross-sectional survey was carried out among antenatal and postnatal women and midwives at private health facilities in Tema using the mixed method to investigate factors associated with uptake of IPTp-SP. Antenatal and postnatal women were consecutively enrolled and data on their sociodemographic characteristics and antenatal service utilization collected using a questionnaire and review of

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Alonso, Yara, Wade Lusengi, Manu F. Manun’Ebo, et al. "The social dimensions of community delivery of intermittent preventive treatment of malaria in pregnancy in Madagascar, Mozambique, Nigeria and the Democratic Republic of the Congo." BMJ Global Health 7, no. 11 (2022): e010079. http://dx.doi.org/10.1136/bmjgh-2022-010079.

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IntroductionIntermittent preventive treatment in pregnancy with sulphadoxine pyrimethamine (IPTp) is a key malaria prevention strategy in sub-Saharan African countries. We conducted an anthropological study as part of a project aiming to evaluate a community-based approach to the delivery of IPTp (C-IPTp) through community health workers (CHWs) in four countries (the Democratic Republic of Congo, Madagascar, Mozambique and Nigeria), to understand the social context in order to identify key factors that could influence C-IPTp acceptability.MethodsA total of 796 in-depth interviews and 265 focus

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Nwaefuna, Ekene K., Richmond Afoakwah, Verner N. Orish, Alexander Egyir-Yawson, and Johnson N. Boampong. "Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against SubmicroscopicfalciparumMalaria in Central Region, Ghana." Journal of Parasitology Research 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/959427.

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Malaria infections undetectable by microscopy but detectable by Polymerase Chain Reaction (PCR) (submicroscopic malaria) are common in endemic areas like Ghana. Submicroscopic malaria has been linked with severe pregnancy outcomes as well as contributing to malaria transmission. In this cross-sectional study 872 consenting pregnant women (gestation ≥ 20 weeks) were recruited from 8 hospitals in Central Region, Ghana, between July and December 2009. Malaria infection was detected by microscopy and PCR. Haemoglobin was measured and anaemia was defined as haemoglobin lower than 11 g/dL. Majority

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Kabuya, Jean-Bertin Bukasa, Matthew M. Ippolito, Jay Sikalima, et al. "Safety and efficacy of intermittent presumptive treatment with sulfadoxine-pyrimethamine using rapid diagnostic test screening and treatment with dihydroartemisinin-piperaquine at the first antenatal care visit (IPTp-SP+): study protocol for a randomized controlled trial." Trials 22, no. 1 (2021). http://dx.doi.org/10.1186/s13063-021-05745-0.

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Abstract Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organization for the prevention of malaria in pregnancy (MIP)-associated adverse outcomes in high burden areas. However, the efficacy of IPTp-SP has decreased in step with increasing parasite drug resistance. Suitable alternative strategies are needed. Methods This is a protocol for a phase IIIb open-label, two-armed randomized controlled superiority trial to assess the safety and efficacy of a hybrid approach to IPTp combining screening and treatment

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Mutanyi, Joshua A., Daniel O. Onguru, Sidney O. Ogolla, and Lawrence B. Adipo. "Determinants of the uptake of intermittent preventive treatment of malaria in pregnancy with sulphadoxine pyrimethamine in Sabatia Sub County, Western Kenya." Infectious Diseases of Poverty 10, no. 1 (2021). http://dx.doi.org/10.1186/s40249-021-00887-4.

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Abstract Background Annually, 125.2 million pregnant women worldwide risk contracting malaria, including 30.3 million and 1.5 million in Sub-Saharan Africa and Kenya respectively. At least three doses of sulphadoxine pyrimethamine for intermittent preventive treatment of malaria in pregnancy (IPTp-SP) is recommended for optimal benefit. Kenya recorded low IPTp-SP optimal uptake in 2015. This study investigated the prevalence of and factors influencing IPTp-SP optimal uptake in Sabatia Sub County, Western Kenya. Methods A cross-sectional study was conducted in Sabatia Sub County from April to O

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