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Dissertations / Theses on the topic 'Iron Complexes - Anticancer Agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Muniz, Carvalho Edinilton. "Metallo-drugs as nitric oxide (NO•) and/or nitroxyl(HNO) donors : development of new agents and investigation of anticancer, antihypertensive and antituberculosis activities." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30217.

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Le cancer, les maladies cardiovasculaires et la tuberculose (TB) sont des défis de santé majeurs pour lesquels diverses stratégies médicamenteuses ont été développées, y compris l'utilisation d'agents inorganiques tels que des complexes métalliques et l'oxyde nitrique (NO•) ou le nitroxyle (HNO). L'objectif de la thèse porte sur la conception, la synthèse, les études physico-chimiques et l'évaluation biologique de molécules à base de métaux capables de libérer NO• et/ou HNO avec des effets pharmacologiques. Deux types de plates-formes organiques sont envisagés comme ligands des complexes de fe

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2

Gandin, Valentina. "Metal complexes as potential anticancer agents." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426115.

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Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is regarded as one of the most effective drugs, even if severe toxicities and drug resistance phenomena limit its clinical use. Therefore, in recent years there has been a rapid expansion in research and development of novel metal-based anticancer drugs to improve clinical effectiveness, to reduce general toxicity and to broaden the spectrum of activity. The variety of metal ion functions in biology has stimulated the development of new metallodrugs other than Pt drugs with the aim to obtain compounds acti

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3

Farley, Sarah J. "Platinum complexes as potential photochemotherapeutic agents." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3769.

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A major challenge of platinum anticancer therapy lies in overcoming the severe side-effects associated with treatment. Photoactivatable PtIV azido complexes, which are stable in the dark and reduced to cytotoxic PtII species upon irradiation, have recently emerged as a potential site-specific treatment. This thesis is concerned with the investigation of PtII and PtIV azido complexes as potential cytotoxic and photochemotherapeutic agents. PtII azido complexes such as [Pt(en)(N3)2] were shown to bind to both 5'-guanosine monophosphate (5'-GMP) and glutathione, at a much reduced rate compared wi

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4

Noffke, Anna Louise. "Arene ruthenium(II) thiosemicarbazone complexes as anticancer agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/66956/.

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This thesis presents the synthesis and characterisation of thiosemicarbazones (TSCs) and their arene ruthenium complexes for the use as anticancer agents. Based on substituted benzaldehyde derivatives, 12 different TSCs were used as N,S-chelating ligands in 24 different ruthenium half-sandwich complexes. The variations in their general structure [(p-cymene)Ru(RTSC)Z]+[A] include the use of both chloride and iodide as monodentate Z ligand. Iodine substituents in the TSC (R = I) were used to introduce a possible tracer moiety. Structure and reactivity elucidations by NMR, ESI-MS and X-ray absorp

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5

Chardon, Edith. "N-Heterocyclic carbene complexes : toward innovative anticancer agents." Strasbourg, 2011. http://www.theses.fr/2011STRA6265.

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Parmi les agents thérapeutiques utilisés en chimiothérapie, la molécule la plus connue et utilisée dans le monde est le cisplatine ou cis-diamminedichloroplatinum(II) démontrant le potentiel des métaux en chimie médicinale. Malheureusement, le cisplatine engendre de nombreux effets secondaires importants et une résistance cellulaire. Dans la quête de nouveaux agents anticancéreux, les complexes de carbènes N-hétérocycliques (NHC) de métaux de transition constituent des candidats prometteurs. C’est dans ce contexte que s’est inscrit l’objet du projet de thèse qui a consisté en la synthèse et l’

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6

Bertrand, Benoit. "Gold-based complexes : synthesis and evaluation as anticancer agents." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS013.

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Depuis sa mise sur le marché à la fin des années 70, le Cisplatin est devenu l’un des pricipaux agents de chimiothérapie anticancéreuse. Actuellement, les composés à base de platine sont présents dans la majorité des coktails de chimiothérapie. Cependant, malgré leur succès clinique, ces composés présentent de nombreux inconvenients comme par exemple de nombreux et graves effets secondaires. Une des stratégies envisagées pour parer à ces défauts a été de remplacer le platine par d’autres métaux de transition. Parmi les différents métaux possibles, l’or est apparu comme particulièrement promett

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7

Lim, Zhi Jun. "Ruthenium arene complexes as anticancer agents: an XAS study." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10398.

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Two Ru(III) complexes that have already entered clinical trials, [ImH]trans-[RuCl4(dmso)(Im)] (NAMI-A, Im = imidazole) and [InH]trans-[RuCl4(Ind)2] (KP1019, Ind = indazole), are potential alternatives to Pt chemotherapeutic drugs since they are effective against cancers untreatable by cisplatin. These compounds have been proposed to operate by an “activation by reduction” process, with a reduction of Ru(III) to the more active Ru(II) species in vivo, which has thus generated an interest towards organometallic Ru(II) arene complexes. The leading complexes of this field would be the RAPTA-C pi

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8

Cross, Jasmine Mary. "Synthesis and analysis of pseudo-octahedral metal complexes as anticancer agents." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12772/.

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Chemotherapy is one of the most predominantly used treatments for cancer. Identifying desirable features required of anticancer agents has rapidly developed alongside our growing understanding of the disease. Metal complexes are of interest as drug candidates as they provide advantages over purely organic systems via modular synthesis, variable geometries and oxidation states. Currently, platinum drugs such as cisplatin remain the most common metal-based treatments, despite their known toxicity towards healthy cells. Viable complexes are therefore sought as alternatives that overcome the limit

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9

Rodriguez, Barzano Andrea. "Novel ruthenium complexes and their applications as catalysts and anticancer agents." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4947/.

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10

Alzahrani, Mona Moshref. "Development of New Vanadium and Iron complexes for potential anticancer drugs." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/dissertations/2877.

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In recent years, metals based antitumor complexes have played an important role in chemotherapy. In this study, two new metal complexes - dioxovandium LVO2 and dichloroiron LFeCl2-have been synthesized. The dioxovanadium complex LVO2 is formed from the reaction between the ligand HL and VO(acac)2 in 1:1 molar ratio, while the dichloroiron complex was prepared from the reaction between ligand HL with FeCl2 in 1:2 molar ratio. Both new complexes have been characterized by FT -IR and UV -Vis. The IR spectrum revealed the absorption band changes between the complexes and their ligand, and UV -Vis

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11

Myburgh, Jolanda. "Synthesis and characterization of novel platinum complexes : their anticancer behaviour." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018621.

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In this dissertation novel non-leaving groups were employed to synthesize platinum complexes which can contribute to the understanding or improvement of anticancer action. These complexes basically consist of (NS)-chelate and amineplatinum complexes. Bidentate (NS)-donor ligands were used as non-leaving ligands in the syntheses of platinum(II) complexes with iodide, chloride, bromide and oxalate anions as leaving groups. These complexes were synthesized and studied since many questions regarding the interaction of sulfur donors and platinum still exists. These relate to thermodynamic and kinet

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12

Suntharalingam, Kogularamanan. "Metal poly-pyridyl complexes as quadruplex DNA binders and potential anticancer agents." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/17878.

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Over the past few years, G-quadruplex DNA has been established as a potential target for anti-cancer drugs. The formation of quadruplexes in the promoter region of certain oncogenes (such as c-myc) is thought to play an important role in regulating their expression. Furthermore the stabilisation of quadruplex DNA in the telomeric region is thought to inhibit telomerase, an enzyme overexpressed in cancerous cells and related to cell proliferation. Therefore the development of small molecules with the ability to interact selectively with quadruplex DNA is receiving increasing attention. In parti

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13

Thomas, Donald S. "Molecular modelling and NMR studies of multinuclear platinum anticancer complexes." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0009.

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[Truncated abstract] The trinuclear anti-cancer agent [(trans-Pt(NH3)3Cl)2{μ-trans-Pt(NH3)2(H2N(CH2)6NH2)2}]4+ (BBR3464 or 1,0,1/t,t,t) is arguably the most significant development in the field of platinum anti-cancer agents since the discovery of cisplatin as a clinical agent more than 30 years ago. Professor Nicholas Farrell of Virginia Commonwealth University was responsible for the development of 1,0,1/t,t,t and an entire class of multinuclear platinum complexes. The paradigm shift that was required in the development of these compounds is based on a simple idea. In order to increase the f

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14

Melchart, Michael. "Mono- and bi-functional chelated ruthenium(II) arene complexes as potential anticancer agents." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12651.

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15

Sun, Yang. "STUDY OF THE MECHANISM OF ACTION FOR Ru(II) POLYPYRIDYL COMPLEXES AS POTENTIAL ANTICANCER AGENTS." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/97.

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Application of chemotherapeutic agents in current cancer treatment has been limited by adverse effects as poor selectivity results in systemic toxicity; most chemotherapy approaches also experience inherited or acquired drug resistance which lead to reduced treatment outcome. Research efforts have focused on the discovery of novel chemotherapies that overcome the limitations mentioned above. Ru(II) polypyridyl complexes with anti-cancer properties have been extensively studied as traditional cytotoxic agents and photodynamic therapy agents due to their photophysical and photochemical character

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16

Shum, Yuen-ting. "Functionalized platinum (II) and gold (I) acetylide complexes structural and spectroscopic properties and anticancer activities /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38639865.

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17

Smith, Kerri M. "Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824.

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18

Keter, Frankline Kiplangat. "Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating the effects of palladium(II) and platinum(II) complexes as anticancer agents.

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19

Alam, Md Mahbubul <1976&gt. "Synthesis and characterization of novel ligands and application of their transition metal complexes as catalysts or anticancer agents." Doctoral thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/8353.

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In this Thesis work, we report an innovative approach for the synthesis of 2-bromoacrylic acid and its ester derivatives that are the key intermediates in the synthesis of chiral aryloxypropionic acid an important class of herbicides. The synthesis of the bromo substitued acrylics was carried out via carbonylation of (trimethylsilyl)acetylene using as catalytic system Pd(OCOCH3)2 in combination with CH3SO3H and 2-(6-methyl)(diphenylphosphine)pyridine. When the reaction is carried out in methanol, methyl 2-(trimethylsilyl)acrylate was obtained in good yields with a branched/linear ratio 95/5. O

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20

TOSO, LEONARDO. "Design, synthesis and characterization of new iron and aluminium chelating agents." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266432.

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Chelation therapy is widely used for metal-unbalance related diseases, namely those due to disorders on metal metabolism, such as beta-thalassemia, hemochromatosis (Fe), and neurodegenerative diseases (Cu, Fe, Zn and Al). The study of metal chelators for clinical applications, either as chelating therapeutics able to target specific metal ions in the body, or as metal-carriers for therapeutic or imaging purposes, is a topical research area which faces up to urgent medical problems. Metal-chelating drugs are used in many ways for the prevention, diagnosis and treatment of cancer, since cancer

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21

Chan, Sau-han, and 陳秀嫻. "Non-heme iron(III) and gold(III) complexes with dicarboxamide ligands: synthesis, structures and anti-cancerproperties." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557984.

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22

Wong, Lai-Ming Ella. "Iron and ruthenium complexes with nitrogen and oxygen donor ligands for anti-cancer and anti-viral studies." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3587742X.

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23

Chan, Sau-han. "Non-heme iron(III) and gold(III) complexes with dicarboxamide ligands synthesis, structures and anti-cancer properties /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557984.

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24

Kolanowski, Jacek Lukasz. "Bispidine-iron (II) complexes as a novel platform for the design of magentogenic probes." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-01059820.

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This work concerns the development and characterization of molecular probes that respond to a chemical analyte in a liquid sample by turning from a diamagnetic to a paramagnetic state (off-on mode).With the aim of designing these tools, we focused on iron(II) chelates of bicyclic bispidines as they promised, among others, sufficient probe stability, even in competitive media like water. This manuscript describes new robust synthetic protocols for their large-scale preparation. Synthesized bispidine-iron(II) complexes were thoroughly characterized in solution (1D/2D NMR, MS, UV-Vis, CV) and in

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25

Wong, Lai-Ming Ella, and 黃禮明. "Iron and ruthenium complexes with nitrogen and oxygen donor ligands for anti-cancer and anti-viral studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3587742X.

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26

Pitta, Christina. "Iron complexes of 1,2-quinone mono-oximes and their potential as agents for the treatment of chlorosis in plants." Thesis, London Metropolitan University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300684.

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27

Rubbiani, Riccardo [Verfasser], and Ingo [Akademischer Betreuer] Ott. "Gold(I) N-Heterocyclic Carbene Complexes: a Chemical and Biological Study of Therapeutic Potential as New Anticancer Agents / Riccardo Rubbiani ; Betreuer: Ingo Ott." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175822647/34.

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28

Hickey, James Laurence. "Synthetic approaches towards gold (I) and silver (I) complexes of functionalised N-heterocyclic carbene ligands." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0090.

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This work focuses on the design and synthesis of Au(I) and Ag(I) complexes from ligand systems that aim to combine both N-heterocyclic carbene (NHC) and phosphine ligand types. A number of synthetic approaches towards both the ligands and the prepared metal complexes have been developed, with a concerted effort on achieving the desired Au(I) or Ag(I) complexes with minimal reaction steps and synthetic style. The thesis body is divided into two main sections. The first section addresses the preparation of suitable ligand precursors of potential Au(I) and Ag(I) complexes in the form of halo- and

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29

Potgieter, Wilna. "An investigation of the possible anticancer activity of seven novel bi(amido) gold(I) complexes derived from a purine or azole base." Diss., Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-09112009-155357/.

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30

Chevry, Aurélien. "Complexes click de platine et cuivre-NHC : applications en biologie." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2011. http://tel.archives-ouvertes.fr/tel-00653371.

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La cycloaddition 1,3-dipolaire catalysée par le cuivre(I) entre un azoture et un alcyne (CuAAC), réaction de " chimie click " par excellence, suscite un grand intérêt en raison de son efficacité et de sa versatilité. L'objectif premier de cette thèse est d'appliquer cette réaction pour l'élaboration de structures 1,2,3-triazoles fonctionnalisées, en vue d'obtenir des ligands jouant le rôle de " pince à platine ". Les complexes de platine biologiquement actifs rapportés sont de type mono- ou bi-nucléaire et comportent un ou deux cycles triazole. Les complexes obtenus ont fait l'objet d'une étud

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Dominelli, Bruno [Verfasser], Fritz E. [Akademischer Betreuer] Kühn, Fritz E. [Gutachter] Kühn, and Joao D. G. [Gutachter] Correia. "Dinuclear Au(I) Complexes Bearing Bridge-Functionalized NHC Ligands as Anticancer Agents / Bruno Dominelli ; Gutachter: Fritz E. Kühn, Joao D. G. Correia ; Betreuer: Fritz E. Kühn." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1205879951/34.

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32

Berger, Gilles. "Synthesis of chiral vicinal diamines and in vitro anticancer properties of their platinum(II) coordinates." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209376.

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15N-based nuclear magnetic resonance techniques are considered very powerful to study the molecular properties of platinum-containing anticancer agents, these properties being responsible for the efficacy of the compounds, but also for the understanding of resistance mechanisms and toxicity. Therefore, the first part of the present work aimed to develop a new method for synthesizing 15N-labeled, chiral platinum compounds. A theoretical discussion on the nucleophilic ring-opening of aziridines has also been envisaged, rationalizing an interesting regiochemistry question. Indeed, a surprising in

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33

Nowak, René [Verfasser], and Birgit [Akademischer Betreuer] Weber. "pH-Responsive Magnetism of Iron(II) Complexes in Solution and Under Small Confinement as Basis for Smart Contrast Agents / René Nowak ; Betreuer: Birgit Weber." Bayreuth : Universität Bayreuth, 2017. http://d-nb.info/1149522062/34.

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Oberkofler, Jens [Verfasser], Fritz E. [Akademischer Betreuer] Kühn, Fritz E. [Gutachter] Kühn, and Wolfgang [Gutachter] Eisenreich. "Beyond Cisplatin: N-Heterocyclic Carbene Gold(I) Complexes as Anticancer Agents and their Use in Drug Delivery Systems / Jens Oberkofler ; Gutachter: Fritz E. Kühn, Wolfgang Eisenreich ; Betreuer: Fritz E. Kühn." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1220322482/34.

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Ruhayel, Rasha A. "Multinuclear platinum anticancer therapeutics : insights into their solution chemistry and DNA binding interactions from NMR spectroscopy and molecular modelling." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0021.

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In the 1980's, Nicholas Farrell developed a range of structurally distinct multinuclear Pt complexes that form long-range interstrand crosslinks (IXLs) in DNA. The dinuclear complex [{trans-PtCl2(NH3)}2-µ-(H2N(CH2)6NH2)]2+ (1,1/t,t) was the first of this series to show promising results, however, it was the trinuclear complex [{trans-PtCl2(NH3)}2-µ-trans-Pt(NH3)2(H2N(CH2)6NH2)2]4+ (1,0,1/t,t,t or BBR3464) that was chosen for clinical trials based on significantly increased cytotoxicity compared to 1,1/t,t and cisplatin. Molecular biology experiments have shown that 1,1/t,t exclusively forms IX

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Basu, Uttara. "Insights into the Chemistry of Iron Complexes as Imaging and Photocytotoxic Agents." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3753.

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The current thesis addresses the various facets of the chemistry of photocytotoxic iron complexes including their syntheses, characterization, evaluation of the anti-proliferative activities in various cancer cell lines upon photo-exposure, mechanism of cell death, the cellular uptake, localization inside cells, the interaction with double stranded DNA and their ability to induce DNA photocleavage. Chapter I presents a general introduction to cancer and the anticancer agents. It covers various procedures available for cancer treatment and different aspects of chemotherapy are discussed in det

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Basu, Uttara. "Insights into the Chemistry of Iron Complexes as Imaging and Photocytotoxic Agents." Thesis, 2015. http://etd.iisc.ernet.in/2005/3753.

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The current thesis addresses the various facets of the chemistry of photocytotoxic iron complexes including their syntheses, characterization, evaluation of the anti-proliferative activities in various cancer cell lines upon photo-exposure, mechanism of cell death, the cellular uptake, localization inside cells, the interaction with double stranded DNA and their ability to induce DNA photocleavage. Chapter I presents a general introduction to cancer and the anticancer agents. It covers various procedures available for cancer treatment and different aspects of chemotherapy are discussed in det

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Lynch, Mark James. "Metal complexes as potential anticancer agents." Phd thesis, 1994. http://hdl.handle.net/1885/141415.

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Rendina, Louis Michael. "Platinum complexes as anticancer drugs." Phd thesis, 1991. http://hdl.handle.net/1885/141486.

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Garai, Aditya. "Studies on Iron and Cobalt Complexes showing Photo-induced Anticancer Activity." Thesis, 2016. https://etd.iisc.ac.in/handle/2005/4906.

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In this thesis the various facets of the chemistry of photocytotoxic iron and cobalt complexes have been investigated along with their syntheses, characterization, evaluation of the photocytotoxic activities in various cancer cell lines, mechanism of cell death, the cellular uptake, localization inside cells, photo release, the interaction with double stranded DNA and their ability to induce DNA photocleavage. Chapter I describes a general introduction on application of transition metal complexes for photochemotherapeutic activity. A brief introduction regarding Photodynamic Therapy (PDT) as

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Wu, Adam. "Synthesis and characterization of ruthenium maltolato, sulfoxide, and nitroimidazole complexes as potential anticancer agents." Thesis, 2002. http://hdl.handle.net/2429/13641.

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The anticancer properties of Ru sulfoxide and imidazole complexes, including cis-RuCl₂(DMSO)₃(DMSO), trans-RuCl₂(DMSO)₄, and [trans-Ru(Im)(DMSO)Cl₄]⁻ have previously been studied by other groups (DMSO and DMSO = S-bonded and O-bonded dimethylsulfoxide, respectively; Im = imidazole). This thesis work concerns the use of Ru maltolato complexes in this regard; maltol (3-hydroxy-2-methyl-4-pyranone), being a non-toxic, water-soluble food additive, is suitable for biological use. [diagrams not included] Several Ru[sup II] bis(maltolato) and bis(ethylmaltolato) complexes with ancillary monodentate a

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Keter, Frankline Kiplangat. "Palladium, platinum and gold complexes: a synthetic approach towards the discovery of anticancer agents." Thesis, 2010. http://hdl.handle.net/10210/3074.

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Ph.D.<br>Ligands bis(pyrazolyl)acetic acid (L1) and bis(3,5-dimethylpyrazolyl)acetic acid (L2) were synthesised by reacting pyrazoles and dibromoacetic acid under phase transfer conditions, by using benzyltriethylammonium chloride as the catalyst. Ligands L1 and L2 were characterised by a combination of 1H, 13C{1H} NMR, IR spectroscopy and microanalysis. Esterification of L1 and L2 led to formation of bis(pyrazolyl)ethyl acetate (L3) and bis(3,5-dimethylpyrazolyl)ethyl acetate (L4). Ligands L3 and L4 were also characterised by a combination of 1H, 13C{1H} NMR, IR spectroscopy and microanalysis

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Lord, Rianne M., J. J. Mannion, A. J. Hebden, et al. "Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes." 2014. http://hdl.handle.net/10454/9495.

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yes<br>Group IV metal complexes have previously shown promise as novel anticancer agents. Here, we discuss the mechanistic and cytotoxic nature of a series of group IV b-diketonate coordination complexes. Clear evidence that the ligands are exchangeable on the metal centre and that the b-diketonate ligands can act as potential drug delivery vehicles of the group IV metal ions was obtained. When evaluated for the cytotoxicity against human colon adenocarcinoma (HT-29) and human breast adenocarcinoma (MCF-7) cell lines, a general trend of decreasing potency down the group IV metals was

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Sithole, Khuphukile. "Phosphine thiocarbohydrate gold (I) complexes and gold nanoparticles as potential anticancer and anti-HIV agents." Thesis, 2012. http://hdl.handle.net/10210/5667.

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M.Sc.<br>The main objective of this project was to synthesize carbohydrates that contain a thiol functional group, commonly known as thiocarbohydrates and subsequently employ them as stabilizing agents in the synthesis of gold nanoparticles and as ligands in the synthesis of phosphine thiocarbohydrate gold(I) complexes. In achieving our objective, thiocarbohydrate compounds 62, 64, 69 and 71 were successfully synthesized from acetylated 60 or benzylated glucal 66 using a Ferrier rearrangement reaction. NaHSO4-SiO2 was used as a catalyst for Ferrier rearrangement reaction in the presence of dit

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Lord, Rianne M., A. J. Hebden, C. M. Pask та ін. "Hypoxia-Sensitive Metal β‑Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis". 2015. http://hdl.handle.net/10454/9491.

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yes<br>A series of ruthenium and iridium complexes have been synthesized and characterized with 20 novel crystal structures discussed. The library of β-ketoiminato complexes has been shown to be active against MCF-7 (human breast carcinoma), HT-29 (human colon carcinoma), A2780 (human ovarian carcinoma), and A2780cis (cisplatin-resistant human ovarian carcinoma) cell lines, with selected complexes’ being more than three times as active as cisplatin against the A2780cis cell line. Selected complexes were also tested against the noncancerous ARPE-19 (retinal pigment epithelial cells) cell

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Rodríguez-Bárzano, A., Rianne M. Lord, A. M. Basri, Roger M. Phillips, A. J. Blacker та P. C. McGowan. "Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands". 2014. http://hdl.handle.net/10454/9498.

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yes<br>The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

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Pramanik, Anup Kumar. "Cytotoxicity of Metal Based Anticancer Active Complexes and their Targeted Delivery using Nanoparticles." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3154.

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Use of metal based anticancer medication began with the clinical approval of cisplatin in 1978. Research led to the development of six platinum based drug candidates which are in use around the world. However there is a great need to develop better treatment strategies. The present work entitled “Cytotoxicity of Metal Based Anticancer Active Complexes and Their Targeted Delivery Using Nanoparticles” is an effort to prepare cytotoxic metal complexes based on platinum(IV) and copper(II) and deliver them selectively to cancer cells using a targeting ligand, biotin, with two different delivery ve

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Pramanik, Anup Kumar. "Cytotoxicity of Metal Based Anticancer Active Complexes and their Targeted Delivery using Nanoparticles." Thesis, 2016. http://hdl.handle.net/2005/3154.

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Use of metal based anticancer medication began with the clinical approval of cisplatin in 1978. Research led to the development of six platinum based drug candidates which are in use around the world. However there is a great need to develop better treatment strategies. The present work entitled “Cytotoxicity of Metal Based Anticancer Active Complexes and Their Targeted Delivery Using Nanoparticles” is an effort to prepare cytotoxic metal complexes based on platinum(IV) and copper(II) and deliver them selectively to cancer cells using a targeting ligand, biotin, with two different delivery ve

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Teixeira, Ricardo Jorge Gonçalves. "Synthesis of new 3D-n5-carboranyl and n5-methylcyclopentadienyl ruthenium complexes incorporating bipyridine (macro) ligands as promising anticancer agents." Master's thesis, 2017. http://hdl.handle.net/10451/31808.

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Tese de mestrado, Química (Química) Universidade de Lisboa, Faculdade de Ciências, 2017<br>Cancer is considered one of the leading causes of death worldwide. Therefore, the search for potential anticancer drugs is nowadays a mandatory topic and many research groups focus their interests and efforts in this area. About 50-70 % of all tumors are treated with platinum based compounds (cisplatin, carboplatin and oxaliplatin) but due to several and severe side effects caused by these metallodrugs and to the resistance phenomena (acquired or intrinsic), complexes with metal ions other than platinum,

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"Anticancer activity and mechanistic study of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074234.

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Aim. The aim of this study was to synthesize and characterize novel analogues of [DACH-Pt-DMC] by using different stereoisomers of DACH; and to investigate any differences in in vitro activity of these complexes in human hepatocellular carcinoma (HCC), colorectal carcinoma (CRC) cell lines and acquired cisplatin or oxaliplatin resistant sub-lines, and to compare that of oxaliplatin and other established Pt-based anticancer agents. Mechanistic roles of DACH-Pt- and DMC components of the TCM-Pt complexes on affecting HCT 116 human CRC cell line were investigated by flow cytometry, COMET assay an

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