Log in

Relevant bibliographies by topics / Iron Metabolism / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Iron Metabolism.

Dissertations / Theses on the topic 'Iron Metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Iron Metabolism.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

SAITO, HIROSHI. "METABOLISM OF IRON STORES." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20543.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Alvarez-Hernandez, J. "Iron metabolism in macrophages." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375442.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Xue, Yue 1978. "Iron metabolism in mammalian cells." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79216.

Full text

Abstract:

Iron, known for its versatility, is an essential element in the metabolism of mammalian cells. One of the most common iron disorders is autosomal recessive disease---hereditary hemochromatosis, which leads to the iron overload in population of northern European descent. During years of my graduate research, I focused on the study of Hemochromatosis gene Hfe and a point mutation C282Y that leads to more than 80% of all hemochromatosis cases.<br>Iron Regulatory Proteins (IRPs), which serve as main posttranscriptional regulators of cellular iron homeostasis, are the other interest of resea

APA, Harvard, Vancouver, ISO, and other styles

4

Whitnall, Megan. "Iron metabolism, chelation and disease." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28914.

Full text

Abstract:

Organisms depend on iron to survive. This fact is underscored by the critical requirement for iron during DNA synthesis and as a cofactor in proteins involved in respiration and oxygen transport. However, when present in excess of cellular requirements, iron can be toxic, due to its ability to generate reactive oxygen species and induce oxidative stress. The physiological significance of iron renders it a target for the development of iron chelators as therapeutic agents and highlights the potential problems that can occur when iron regulatory pathways are disturbed in disease. The rapid rat

APA, Harvard, Vancouver, ISO, and other styles

5

Ekins, Andrew John. "Iron acquisition by Histophilus ovis." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38481.

Full text

Abstract:

Five strains (9L, 642A, 714, 5688T and 3384Y) of Histophilus ovis were investigated with respect to iron acquisition. All strains used ovine, bovine and goat, but not porcine or human, transferrins (Tfs) as iron sources for growth. In solid phase binding assays, total membranes from only two (9L and 642A) of the five strains, grown under iron-restricted conditions, were able to bind Tfs (ovine, bovine and goat, but not porcine or human). However, when the organisms were grown under iron-restricted conditions in the presence of bovine Tf, total membranes from all strains exhibited Tf binding (a

APA, Harvard, Vancouver, ISO, and other styles

6

Sritharan, Manjula. "Studies in iron metabolism of mycobacteria." Thesis, University of Hull, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278446.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Lopes, Tiago Jose da Silva. "Systems biology analysis of iron metabolism." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16417.

Full text

Abstract:

Jede Zelle des Säugetierorganismus benötigt Eisen als Spurenelement für zahlreiche oxidativ-reduktive Elektronentransfer-Reaktionen und für Transport und Speicherung von Sauerstoff. Der Organismus unterhält daher ein komplexes Regulationsnetzwerk für die Aufnahme, Verteilung und Ausscheidung von Eisen. Die intrazelluläre Regulation in den verschiedenen Zelltypen des Körpers ist mit einer globalen hormonellen Signalstruktur verzahnt. Sowohl Eisenmangel wie Eisenüberschuss sind häufige und ernste menschliche Krankheitsbilder. Sie betreffen jede Zelle, aber auch den Organismus als Ganzes. In die

APA, Harvard, Vancouver, ISO, and other styles

8

Bahrami, Fariborz. "Iron acquisition in Actinobacillus suis." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85880.

Full text

Abstract:

Seven strains of Actinobacillus suis (ATCC 15557, B49, C84, H89-1173, H91-0380, SO4 and VSB 3714) were investigated with respect to iron acquisition from animal transferrins (Tfs) and haemoglobins (Hbs). Growth assays with porcine, bovine and human Tfs and Hbs revealed that all seven strains could use porcine (but not human or bovine) Tf and all three Hbs as iron sources. In solid phase binding assays, membranes derived from all strains exhibited strong binding of porcine Tf and each of the Hbs. Competition binding assays indicated that all three Hbs were bound by the same receptor(s).

APA, Harvard, Vancouver, ISO, and other styles

9

Bae, Dong-Hun. "The Effects of Iron Levels on the Interaction between Polyamine Metabolism and Iron Metabolism in Neoplastic Cells." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18081.

Full text

Abstract:

Iron is a crucial element that is associated with many metabolic pathways important for life sustaining processes. Polyamines are small positively charged polycations involved in various physiological functions. Both iron and polyamines levels are known to be high in cancer cells which suggests a possible unexplored link between the two metabolic pathways. For the first time, we demonstrate that iron-depletion robustly regulates the expression of 13 polyamine pathway proteins. Iron-depletion also decreased polyamine and S-adenosylmethionine levels (required for spermidine/spermine biosynthesi

APA, Harvard, Vancouver, ISO, and other styles

10

Tremblay, Yannick. "Acquisition of haemoglobin-bound iron by Histophilus somni." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82441.

Full text

Abstract:

Ovine (strains 9L and 3384Y) and bovine (strains 649, 2336 and 8025) isolates of Histophilus somni were investigated for their ability to acquire iron from haemoglobin (Hb). Bovine isolates were capable of utilizing bovine, but not ovine, porcine or human Hb as a source of iron. Ovine isolates could not obtain iron from Hb. Bovine isolates bound bovine, ovine, and human Hbs by means of the same iron-repressible receptor(s) and produced a ~120-kDa iron-repressible, outer membrane protein. Using PCR approaches, an iron-regulated operon containing hugX and hugZ homologues and a gene (hgbA)

APA, Harvard, Vancouver, ISO, and other styles

11

Zetterström, Fernaeus Sandra. "Changed iron metabolism and iron toxicity in scrapie-infected neuroblastoma cells." Doctoral thesis, Stockholm University, Department of Neurochemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-661.

Full text

Abstract:

<p>Reactions and interactions of iron and oxygen can be both beneficial and detrimental to cells and tissues. Iron is mainly found in our blood where it functions as a mediator in the transport of oxygen to the cells and is further vital for the cellular respiration reducing the oxygen to water. The flexible redox state of iron makes it ideal to contribute in single electron transfers, but may also catalyze reactions with oxygen resulting in cell damaging reactive oxygen species (ROS). Normally the cells are protected against iron toxicity by controlling iron uptake and storage. When the intra

APA, Harvard, Vancouver, ISO, and other styles

12

Zetterström, Fernaeus Sandra. "Changed iron metabolism and iron toxicity in scrapie-infected neuroblastoma cells /." Stockholm : Dept. of neurochemistry, Stockholm university, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-661.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Åkesson, Agneta. "Cadmium exposure and iron status /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4290-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Kobylarz, Marek John. "Siderophore-mediated iron metabolism in Staphylococcus aureus." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57023.

Full text

Abstract:

Staphylococcus aureus requires iron as a nutrient and uses uptake systems to extract iron from the human host. S. aureus produces the iron-chelating siderophore staphyloferrin B (SB) to scavenge for available iron under conditions of low iron stress. Upon iron-siderophore re-entry into the cell, iron is separated from the siderophore complex to initiate assimilation into metabolism. To gain insight into how SB biosynthesis is integrated into S. aureus central metabolism, the three SB precursor biosynthetic proteins, SbnA, SbnB, and SbnG, were biochemically characterized. SbnG is a citrate synt

APA, Harvard, Vancouver, ISO, and other styles

15

Kingsley, Robert Anthony. "Iron uptake and metabolism by Salmonella enterica." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29735.

Full text

Abstract:

Serovars of the genus Salmonella scavenge iron (III) chelated with low molecular weight compounds called siderophores. The transport of one such group of siderophores, the ferroxamines, was investigated using sensitivity growth stimulation bioassays. Uptake of all three ferrioxamines tested was demonstrated to be dependent upon transport across the outer membrane via the FoxA protein. Wild-type levels of transport required the TonB protein, however, lower yet significant transport of iron complexed with ferroixamines B and E, but not G, appeared to occur by a TonB-independent mechanism. Transp

APA, Harvard, Vancouver, ISO, and other styles

16

Nixon, Gavin James. "Studies in the iron metabolism of mycobacteria." Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310267.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Hoque, Rukshana. "The effects of quercetin on iron metabolism." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-effects-of-quercetin-on-iron-metabolism(c3f5d9ca-eeaf-4fa7-9878-5b04552e6367).html.

Full text

Abstract:

Polyphenols are known to be major inhibitors of dietary non-haem iron bioavailability, mainly through their action as iron chelators. In this present study Caco-2 cells were used to investigate the influence of quercetin, the most abundant flavonol in the diet, on non-haem iron bioavailability using 55Fe, and the gene expression of intestinal iron transporters as measured via qPCR. Chronic exposure to quercetin (24 hours) had no significant effect on iron uptake but iron efflux was significantly decreased. Consistent with this, qPCR analysis revealed a significant decrease in basolateral trans

APA, Harvard, Vancouver, ISO, and other styles

18

Mitchell, Simon. "A computational model of human iron metabolism." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/a-computational-model-of-human-iron-metabolism(c3afe167-4a40-42aa-8fd8-a65e47dfe7eb).html.

Full text

Abstract:

Iron is essential for virtually all organisms, yet it can be highly toxic if not properly regulated. Only the Lyme disease pathogen Borrelia burgdorferi has evolved to not require iron (Aguirre et al., 2013).Recent findings have characterised elements of the iron metabolism network, but understanding of systemic iron regulation remains poor. To improve understanding and provide a tool for in silico experimentation, a computational model of human iron metabolism has been constructed. COPASI was utilised to construct a model that included detailed modelling of iron metabolism in liver and intest

APA, Harvard, Vancouver, ISO, and other styles

19

Xu, Xiangcong. "THE MOLECULAR MECHANISMS OF IRON AND FERRITIN METABOLISM IN." University of Sydney, 2008. http://hdl.handle.net/2123/3535.

Full text

Abstract:

Doctor of Philosophy(PhD)<br>Iron (Fe) is essential for cell growth and replication as many Fe-containing proteins catalyse key reactions involved in energy metabolism (cytochromes, mitochondrial aconitase and Fe-S proteins of the electron transport chain), respiration (hemoglobin and myoglobin) and DNA synthesis (ribonucleotide reductase). If not appropriately shielded, Fe could participate in one-electron transfer reactions that lead to the production of extremely toxic free radicals. The Fe storage protein, ferritin, is essential to protect cells against Fe-mediated oxidative stress by acco

APA, Harvard, Vancouver, ISO, and other styles

20

Gelling, Cristy Lee Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Tetrahydrofolate and iron-sulfur metabolism in Saccharomyces cerevisiae." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/43270.

Full text

Abstract:

Tetrahydrofolate-mediated one-carbon metabolism is required for the biosynthesis of many central metabolites, including some amino acids, nucleobases, and nucleotides, and hence dysfunction of one-carbon metabolism is associated with many human diseases and disorders. The mitochondrial glycine decarboxylase complex (GDC) is an important component of one-carbon metabolism, generating 5,10-methylene-tetrahydrofolate (5,10-CH2-H??4folate) from glycine. Previous work has shown that the genes encoding the unique sub-units of the Saccharomyces cerevisiae GDC (GCV1, GCV2 and GCV3) are regulated in

APA, Harvard, Vancouver, ISO, and other styles

21

Dzikaitė, Vijolė. "Studies of proteins in heme and iron metabolism /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-762-2/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Sun, Xuesong. "Iron metabolism mediated by MtsA, transferrin and desferrioxamine." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37552995.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Sun, Xuesong, and 孫雪松. "Iron metabolism mediated by MtsA, transferrin and desferrioxamine." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38722446.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Moshtaghie, A. A. "Interrelationships between aluminium and iron metabolism in man." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380213.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Ferreira, Patrícia Daniela Oliveira. "Regulation of iron metabolism in different bacterial infections." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14598.

Full text

Abstract:

Mestrado em Biomedicina Molecular<br>Iron is found in almost all living organisms, playing a central role in host-pathogen interactions and being crucial for both host and pathogens. In the host, iron is a crucial element, since it plays a key role in biological processes such as oxygen transport, biosynthesis of DNA, energy production and regulation of gene expression. However, high concentrations of iron can also be toxic to cells due to the ability to generate hydroxyl radicals. Thus, vertebrates developed proteins to transport and store iron: transferrin and ferritin, respectivetly. Hepcid

APA, Harvard, Vancouver, ISO, and other styles

26

Govus, Andrew. "The regulation of human iron metabolism in hypoxia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2015. https://ro.ecu.edu.au/theses/1719.

Full text

Abstract:

Athletes commonly use altitude exposure in an attempt to improve their aerobic performance at sea level. Altitude exposure enhances erythropoiesis and iron-dependent oxidative and glycolytic enzyme production, for this reason, athletes must maintain a healthy iron balance at altitude. A negative iron balance at altitude may limit such physiological adaptations, potentially reducing the performance benefits of altitude exposure. This thesis examined the regulation of iron metabolism during acute (~31 min, Study One) and prolonged altitude exposure (14 days, Study Two). Finally, Study Three exam

APA, Harvard, Vancouver, ISO, and other styles

27

Maddocks, Sarah Elizabeth. "Iron metabolism in bacteria : examination of the Feo system (Ferrous iron transporter) and Dps-iron storage proteins." Thesis, University of Reading, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434313.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Danzeisen, Ruth. "Iron metabolism by BeWo cells : the role of copper and iron in the regulation of placental iron transfer." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364703.

Full text

Abstract:

In this thesis, the regulation of placental Fe metabolism is investigated, using a placental choriocarcinoma cell line (BeWo). Both copper (Cu) and iron (Fe) status are examined for a possible role in the process of placental Fe transfer. Firstly, the involvement of Cu in Fe release is tested. Ceruloplasmin (Cp), a plasma Cu carrier and ferroxidase, is implicated in Fe release from a variety of cell types, but does not stimulate Fe release from BeWo cells. Instead, evidence is presented for a membrane-associated ferroxidase with homology to Cp, expressed by BeWo cells. This placental protein h

APA, Harvard, Vancouver, ISO, and other styles

29

Wang, Jian 1966. "Molecular control of iron metabolism in mammalian cells : new insights into iron regulatory proteins." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86063.

Full text

Abstract:

Iron is an essential but potentially harmful metal element. Iron regulatory protein 1 and IRP2 posttranscriptionally control cellular iron homeostasis by binding to iron-responsive elements (IREs). Binding of IRPs to single IRE within 5'-untranslated region (5'-UTR) of ferritin mRNA attenuates biosynthesis of the iron-storage protein by translational repression, while their binding to multiple IREs within 3'-UTR of transferrin receptor 1 (TfR1) mRNA stimulates that of the iron-acquisition protein through mRNA stabilization. IRP1 and IRP2 share extensive homology, but respond to levels o

APA, Harvard, Vancouver, ISO, and other styles

30

Stys, Agnieska. "Role of iron regulatory proteins in the regulation of iron metabolism by nitric oxide." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T056.

Full text

Abstract:

Les Iron Regulatory Proteins 1 (IRP1/2) sont des protéines cytosoliques qui contrôlent l’homéostasie du fer chez les mammifères. Elles régulent la concentration de fer intracellulaire au niveau post-transcriptionnel, en interagissant spécifiquement avec des motifs appelés iron responsive élément (IREs). Ces motifs sont localisés dans les régions non traduites des ARNm codant notamment pour la ferritine (Ft), la ferroportine (Fpn) et le récepteur de la transferrine (TfR1). L’IRP1 est une protéine bifonctionnelle, majoritairement exprimée sous une forme contenant un centre [4Fe-4S] qui présente

APA, Harvard, Vancouver, ISO, and other styles

31

Quisumbing, Teresita Lambo. "Studies of iron metabolism and metabolic rate in iron-deficient and cold-acclimatized rats." Hong Kong : University of Hong Kong, 1985. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1231545X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

SIGHINOLFI, SILVIA. "INTRACELLULAR IRON OVERLOAD AFFECTS HSC METABOLISM BY IMPAIRING MITOCHONDRIAL FITNESS IN β-THALASSEMIA". Doctoral thesis, Università Vita-Salute San Raffaele, 2023. https://hdl.handle.net/20.500.11768/137019.

Full text

Abstract:

Mitochondrial activity and metabolism significantly control hematopoietic stem cell (HSC) function and fate. HSCs change the metabolic state in response to stress signals, such as reactive oxygen species (ROS), which drive HSC entry into cell cycle accompanied by increased mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis. However, excessive accumulation of ROS results in oxidative damage of cellular organelles, including mitochondria. Iron is one of the sources of ROS and HSCs can uptake iron but little is known about the effects of iron on HSC metabolism. Recently, we demonstr

APA, Harvard, Vancouver, ISO, and other styles

33

Fosset, Cedric. "Iron and copper interactions in humans : models and mechanisms." Thesis, Robert Gordon University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268863.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Morris, Patricia Ann. "EXAFS of non-heme iron containing proteins." Diss., Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/27402.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Peers, Graham Stewart. "Increased metabolic requirements for manganese and copper in iron-limited marine diatoms." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85950.

Full text

Abstract:

Productivity in large areas of the world's oceans is limited by low concentrations of dissolved iron in surface waters. Phytoplankton have adapted to persist in these environments by reducing their requirements for iron (Fe) in key metabolic pathways, in some cases by replacing Fe-containing catalysts with their iron-free functional equivalents. This thesis examines the requirements and biochemical roles for copper (Cu) and manganese (Mn) in Fe-limited centric marine diatoms. A major finding of my research is that diatoms have elevated requirements for Mn and Cu when grown in Fe-deficie

APA, Harvard, Vancouver, ISO, and other styles

36

Constante, Pereira Marco. "Development of synthetic biology devices for iron metabolism research." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/53579.

Full text

Abstract:

Synthetic biology is a fairly recent field that aims to engineer novel functions in biological systems. In a broad sense synthetic biology encompasses the development of tools that makes the engineering of biology easier. In this thesis I develop a collection of standard DNA parts (Biobricks) that consists of a tool to build custom eukaryotic plasmids. This is not just intended for biology researchers in the field of synthetic biology, but also for more general use. Besides the development of molecular biology tools that facilitate the engineering of biology, synthetic biology researchers have

APA, Harvard, Vancouver, ISO, and other styles

37

Metzendorf, Christoph. "Mitochondrial Iron Metabolism : Study of mitoferrin in Drosophila melanogaster." Doctoral thesis, Uppsala universitet, Jämförande fysiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-114201.

Full text

Abstract:

Iron has a dualistic character. On the one hand it is essential for the life of most organisms, on the other hand it is involved in the generation of reactive oxygen species that are implicated in diseases and aging. During evolution efficient mechanisms for uptake, handling and storage of iron in a safe way have developed to keep the balance between iron availability and minimizing the hazards. In eukaryotes, mitochondria are the central organelle for “metabolizing” iron and consequently play an important role in cellular iron homeostasis. Mitoferrins are mitochondrial carrier proteins, which

APA, Harvard, Vancouver, ISO, and other styles

38

Procter, Catherine M. "The roles of the FRO genes in iron metabolism." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313219.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Schiffhauer, Samuel Peter. "Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85398.

Full text

Abstract:

Circadian rhythms are daily molecular oscillations within cells ranging from prokaryotes to humans. This rhythm is self sustaining, and receives external cues in order to synchronize an organism's behavior and physiology with the environment. Many metabolites utilized in metabolic processes seem to follow a pattern of circadian oscillation. Iron, an essential component in cellular processes such as respiration and DNA synthesis, is obtained almost exclusively through diet, yet little is known about how the clock governs iron metabolism. The regulation of iron within the cell is very tightl

APA, Harvard, Vancouver, ISO, and other styles

40

Rhodes, Christopher James. "Iron metabolism and biomarkers in idiopathic pulmonary arterial hypertension." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6915.

Full text

Abstract:

Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease characterised by increased vascular resistance and remodelling of the pulmonary vasculature. This causes strain on the right ventricle, leading eventually to failure and death. Iron status is thought to influence pulmonary vascular tone, particularly in hypoxia, and may be important in IPAH. Proteomic studies of lung tissues from IPAH patients versus control lobectomy samples revealed downregulated levels of the haemoglobin- and haem-scavenging proteins haptoglobin (Hp) and haemopexin. Plasma levels of Hp were also redu

APA, Harvard, Vancouver, ISO, and other styles

41

Müller, Katrin [Verfasser]. "Regulation of iron metabolism during liver injury / Katrin Müller." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2013. http://d-nb.info/1038734851/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Ricard, Michelle. "Iron acquisition from porcine proteins by Actinobacillus pleuropneumoniae biotype 1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0034/MQ64438.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Hawula, Zachary John. "Identification and analysis of genetic and chemical modulators of iron metabolism." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/225904/1/Zachary_Hawula_Thesis.pdf.

Full text

Abstract:

This dissertation focused on identifying novel chemical and genetic modulators of iron homeostasis. Iron is an essential element for human health. Disorders such as anaemia and haemochromatosis can develop when iron levels are not maintained within a normal physiological range. The findings of this program included the identification of a new iron chelating compound, demonstration of iron chelation in a haemochromatosis mouse model by a flavonol, identification of iron metabolism-related genes and variants which may assist in distinguishing suitable blood donors, and the identification of nove

APA, Harvard, Vancouver, ISO, and other styles

44

Salmon, Timothy Peter Civil &amp Environmental Engineering Faculty of Engineering UNSW. "Physiological and genetic characterisation of iron acquisition by the coastal cyanobacterium Lyngbya majuscula (Oscillatoriales)." Publisher:University of New South Wales. Civil & Environmental Engineering, 2007. http://handle.unsw.edu.au/1959.4/40725.

Full text

Abstract:

Large summertime proliferations (or blooms) of the noxious filamentous cyanobacterium Lyngbya majuscula have been observed in the coastal marine waters of Moreton Bay, Queensland. This photosynthetic organism is believed to have a high iron requirement and preliminary studies have shown that the presence of organically complexed iron stimulates growth. Since there is no evidence that Lyngbya produces siderophores to aid iron acquisition, it has been hypothesized that this organism may acquire iron via reduction of ferric complexes to the typically more labile, ferrous form. Both the phylogene

APA, Harvard, Vancouver, ISO, and other styles

45

D'Silva, Colin Gerard. "Iron acquisition by Actinobacillus pleuropneumoniae." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28720.

Full text

Abstract:

Four strains of the swine pathogen Actinobacillus pleuropneumoniae, namely, the type strain (ATCC 27088), the "reference" strain of biotype 2 (Bertschinger 2008/76) and two additional biotype 1 strains, strain BC181, which is less virulent than the type strain, and strain K17 (reference strain of serotype 5A), which was isolated from a lamb, were investigated with respect to iron acquisition. All four strains produced iron-repressible outer membrane proteins. However, only strains ATCC 27088 and Bertschinger 2008/76 could acquire iron from porcine transferrin. No organism could utilize human,

APA, Harvard, Vancouver, ISO, and other styles

46

Mettrick, Karla Adelle, and n/a. "Iron signalling pathways of Pseudomonas aeruginosa." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081128.143145.

Full text

Abstract:

The pathogenic bacterium Pseudomonas aeruginosa uses a variety of highly efficient chelating compounds (siderophores) to acquire sufficient iron for growth and virulence. These siderophores can either be endogenous or acquired from exogenous sources such as other bacteria or fungi. The transport of the endogenous siderophore pyoverdine activates a signal-transduction pathway that increases the synthesis of both the ferripyoverdine receptor protein (FpvA) and pyoverdine itself. Signal-transduction systems similar to this have three specific proteins involved: a receptor protein specific for one

APA, Harvard, Vancouver, ISO, and other styles

47

Park, Thomas. "The Role of NfuA Protein in Acinetobacter baumannii Iron Metabolism." Miami University Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303498264.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Strickland, Natalie Judith. "In silico and functional analyses of the iron metabolism pathway." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79871.

Full text

Abstract:

Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Iron is an essential micronutrient that is an absolute requirement for correct cellular function in all eukaryotic organisms. However, ferrous iron has the ability to catalyze the formation of potentially toxic reactive oxygen species and regulation of iron metabolism is therefore of critical importance. Currently, there is little known about the co-ordinated regulation of the plethora of genes coding for proteins involved in this biochemical pathway, with the exception of the well characterized post-transcriptional IRE/IRP

APA, Harvard, Vancouver, ISO, and other styles

49

Vazzola, V. "Frataxin, a protein involved in iron metabolism, in Arabidopsis thaliana." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/61969.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Tilley, Gareth John. "Electrochemical investigations into iron-sulfur cluster containing proteins." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365300.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!