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Journal articles on the topic 'Iron overload'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Zhabyeyev, Pavel, Subhash K. Das, Ratnadeep Basu, et al. "TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease." American Journal of Physiology-Heart and Circulatory Physiology 314, no. 5 (2018): H978—H990. http://dx.doi.org/10.1152/ajpheart.00597.2017.

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Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3−/−) and wild-type (WT) mice to 12 wk of chronic iron overload. Whereas WT mice with iron overload developed diastolic dysfunction, iron-overloaded Timp3−/− mice showed worsened cardiac dysfunction coupled with systolic dysfunction. In the heart, loss of Timp3 w

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2

Marfil-Rivera, L. J. "Iron overload." Medicina Universitaria 17, no. 69 (2015): 240–42. http://dx.doi.org/10.1016/j.rmu.2015.08.001.

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3

Siah, Chiang W., Debbie Trinder, and John K. Olynyk. "Iron overload." Clinica Chimica Acta 358, no. 1-2 (2005): 24–36. http://dx.doi.org/10.1016/j.cccn.2005.02.022.

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4

Hulihan, Mary M., Cindy A. Sayers, Scott D. Grosse, Cheryl Garrison, and Althea M. Grant. "Iron Overload." American Journal of Preventive Medicine 41, no. 6 (2011): S422—S427. http://dx.doi.org/10.1016/j.amepre.2011.09.020.

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5

Tsay, Jaime, Zheiwei Yang, F. Patrick Ross, et al. "Bone loss caused by iron overload in a murine model: importance of oxidative stress." Blood 116, no. 14 (2010): 2582–89. http://dx.doi.org/10.1182/blood-2009-12-260083.

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AbstractOsteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. The exact role of iron in the development of osteoporosis in these disorders is not established. To define the effect of iron excess in bone, we generated an iron-overloaded mouse by injecting iron dextran at 2 doses into C57/BL6 mice for 2 months. Compared with the placebo group, iron-overloaded mice exhibited dose-dependent increased tissue iron content, changes in bone composition, and trabecular and cortical thinning of bone accompanied by increas

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6

Eka Sari, Retno, and Wahyudi. "Iron Overload Cardiomyopathy." Sumatera Medical Journal 7, no. 3 (2024): 159–67. http://dx.doi.org/10.32734/sumej.v7i3.17796.

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Iron overload cardiomyopathy is a condition of excessive iron accumulation in cardiomyocytes due to abnormal iron absorption or repeated blood transfusion. In the early stages, the patient may be asymptomatic with good ventricular systolic function. Iron deposit in ventricular cause dyspnea on effort due to left ventricular systolic dysfunction then in atrial cause atrioventricular block and supraventricular arrhythmic. For severe symptom due to dilated cardiomyopathy is characterized by left ventricular dilatation and risk of sudden cardiac death. Diagnosis of iron overload cardiomyopathy can

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7

Mangaonkar, Abhishek, Niren Patel, Hongyan Xu, et al. "Plasma Biomarkers of Iron Regulation, Overload, and Inflammation in Sickle Cell Disease." Blood 124, no. 21 (2014): 1380. http://dx.doi.org/10.1182/blood.v124.21.1380.1380.

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Abstract Transfusional iron overload has been increasingly recognized among patients with sickle cell disease (SCD) over the past two decades. We recently reported on the prevalence of iron overload among 635 adult SCD patients followed at our center and found that 80 patients (12%) had developed iron overload as a result of repeated blood transfusions. Fifty six (70%) of these subjects developed iron overload as a result of episodic, mostly unnecessary transfusions at outlying hospitals. There have been reports of association of increased morbidity and mortality among iron overloaded SCD pati

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8

Jacobs, Allan, and A. V. Hoffbrand. "Iron deficiency and iron overload." Critical Reviews in Oncology/Hematology 3, no. 2 (1985): 143–86. http://dx.doi.org/10.1016/s1040-8428(85)80023-8.

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9

Díez-López, Carles, Josep Comín-Colet, and José González-Costello. "Iron overload cardiomyopathy." Current Opinion in Cardiology 33, no. 3 (2018): 334–40. http://dx.doi.org/10.1097/hco.0000000000000511.

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10

Camaschella, Clara. "Treating Iron Overload." New England Journal of Medicine 368, no. 24 (2013): 2325–27. http://dx.doi.org/10.1056/nejmcibr1304338.

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11

Lombard, M., A. Bomford, and R. Williams. "Genetic Iron Overload." Journal of the Royal Society of Medicine 82, no. 12 (1989): 701–3. http://dx.doi.org/10.1177/014107688908201202.

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12

Kushner, James P., John P. Porter, and Nancy F. Olivieri. "Secondary Iron Overload." Hematology 2001, no. 1 (2001): 47–61. http://dx.doi.org/10.1182/asheducation-2001.1.47.

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Abstract Transfusion therapy for inherited anemias and acquired refractory anemias both improves the quality of life and prolongs survival. A consequence of chronic transfusion therapy is secondary iron overload, which adversely affects the function of the heart, the liver and other organs. This session will review the use of iron chelating agents in the management of transfusion-induced secondary iron overload. In Section I Dr. John Porter describes techniques for the administration of deferoxamine that exploit the pharmacokinetic properties of the drug and minimize potential toxic side effec

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13

Kasvosve, I., It Gangaidzo, Zar Gomo, and Vr Gordeuk. "African Iron Overload." Acta Clinica Belgica 55, no. 2 (2000): 88–93. http://dx.doi.org/10.1080/17843286.2000.11754276.

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14

Holding, Cathy. "Iron overload lifted." Genome Biology 4 (2003): spotlight—20031201–01. http://dx.doi.org/10.1186/gb-spotlight-20031201-01.

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15

Gordeuk, Victor R. "African iron overload." Seminars in Hematology 39, no. 4 (2002): 263–69. http://dx.doi.org/10.1053/shem.2002.35636.

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16

Ault, Patricia, and Karen Jones. "Understanding Iron Overload." Clinical Journal of Oncology Nursing 13, no. 5 (2009): 511–17. http://dx.doi.org/10.1188/09.cjon.511-517.

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17

HALLIDAY, J. W. "Inherited Iron Overload." Acta Paediatrica 78 (October 1989): 86–95. http://dx.doi.org/10.1111/apa.1989.78.s361.86.

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18

Turlin, Bruno, and Yves Deugnier. "Iron overload disorders." Clinics in Liver Disease 6, no. 2 (2002): 481–96. http://dx.doi.org/10.1016/s1089-3261(02)00004-1.

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19

Bacon, Bruce R. "IRON OVERLOAD STATES." Clinics in Liver Disease 2, no. 1 (1998): 63–75. http://dx.doi.org/10.1016/s1089-3261(05)70364-0.

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20

Gujja, Pradeep, Douglas R. Rosing, Dorothy J. Tripodi, and Yukitaka Shizukuda. "Iron Overload Cardiomyopathy." Journal of the American College of Cardiology 56, no. 13 (2010): 1001–12. http://dx.doi.org/10.1016/j.jacc.2010.03.083.

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21

Izzy, Manhal, and Patrick S. Kamath. "Severe Iron Overload." Clinical Gastroenterology and Hepatology 17, no. 13 (2019): A28. http://dx.doi.org/10.1016/j.cgh.2018.08.032.

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22

Marcus, Robert E., and E. R. Huehns. "Transfusional iron overload." Clinical & Laboratory Haematology 7, no. 3 (1985): 195–212. http://dx.doi.org/10.1111/j.1365-2257.1985.tb00026.x.

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23

Munoz, Javier, Natalia Ferrari, and Philip Kuriakose. "Iron-overload myopathy." International Journal of Hematology 94, no. 6 (2011): 503–4. http://dx.doi.org/10.1007/s12185-011-0961-1.

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24

El-Sheikh, Arwa A., Shimaa Hamed Ameen, and Samaa Salah AbdEl-Fatah. "Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine." Journal of Toxicology 2018 (November 21, 2018): 1–13. http://dx.doi.org/10.1155/2018/8023840.

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Objective. The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible underlying molecular mechanisms of such toxicity. Methods. Forty-two adult male albino rats were divided into six groups: control groups, DFO, Quercetin, iron overload, iron overload+DFO, and iron overload+Quercetin groups. Animals received daily intraperitoneal injection of Deferoxamine (125 mg /kg), Quercetin (10 mg/kg), and ferric dextran (200 m

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25

AL-Rousan, Rabaa, Anjaiah Katta, Satyanarayana Paturi, et al. "Chronic Deferasirox Administration Decreases Hepatic Oxidative Stress and Apoptosis in the Iron Overloaded Gerbil." Blood 114, no. 22 (2009): 1996. http://dx.doi.org/10.1182/blood.v114.22.1996.1996.

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Abstract Abstract 1996 Poster Board I-1018 Background: Iron overload occurs under conditions such as primary (hereditary) hemochromatosis and secondary iron overload (hemosiderosis) and is associated with an increased risk of developing liver fibrosis, cirrhosis, and hepatocellular carcinoma. Deferasirox is a novel oral chelator with high iron-binding potency and selectivity. Here we investigate the ability of deferasirox to remove excessive hepatic iron and prevent or reverse iron induced hepatic injury. Methods: Adult male Mongolian Gerbils were randomly divided into three groups: control, i

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26

Naeem, Uzma, Rabia Azhar, Wajiha Shadab, Nazir Awan, Maryam Naeem, and Jawairia Iftikhar. "Comparative Effects of Nigella Sativa and Cassia Senna in Iron Overloaded Mice." Pakistan Journal of Medical and Health Sciences 16, no. 4 (2022): 1222–24. http://dx.doi.org/10.53350/pjmhs221641222.

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Background: Iron overload-related complications are the main concern in patients who must often receive blood transfusions. The only way to treat iron overload in these patients is by chelating agents. Owing to the high cost and adverse effects of chelating agents use of naturally present chelators is under study. Aim: To compare the protective effects of two commonly used herbs Nigella Sativa and Cassia Senna in iron-overloaded mice. Study Design: Experimental randomized controlled trial. Setting: Zoology department of Govt College University Lahore during six months period. Method: A total o

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27

Boga, Salih, Huseyin Alkim, Canan Alkim, et al. "The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease." Journal of Gastrointestinal and Liver Diseases 24, no. 3 (2015): 293–300. http://dx.doi.org/10.15403/jgld.2014.1121.243.hak.

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Background & Aims: Mild iron overload is frequently reported in patients with nonalcoholic fatty liver disease (NAFLD). Hepcidin is the master iron-regulatory peptide and hemojuvelin (HJV) is the key regulator of iron-dependent secretion of hepcidin. The aims of this study were to evaluate serum HJV and hepcidin levels in patients with biopsy-proven NAFLD with and without hepatic iron overload, and to identify potential associations of HJV and hepcidin with the clinical characteristics of the patients enrolled. Methods: Serum levels of HJV and hepcidin were measured in 66 NAFLD patie

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28

Yufei, Zhao, Xin Zhao, Wenrui Yang, and Fengkui Zhang. "Hetrombopag, an Emerging Iron-Chelating Agent, Alleviates Systemic Iron Overload." Blood 144, Supplement 1 (2024): 3848. https://doi.org/10.1182/blood-2024-201638.

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Background: Iron overload is a syndrome in which excessive iron accumulates in the body, leading to tissue damage and functional disorders. This condition is common in patients with refractory anaemia who receive long-term red blood cell transfusions. Hetrombopag (HPAG) is a new generation, oral, small molecule, nonpeptide thrombopoietin receptor agonist that can chelate iron and alleviate iron overload while promoting haematopoiesis. Nevertheless, there is currently a lack of research on the iron-chelating function of HPAG, and its mechanism of regulating iron metabolism in the body is not cl

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29

Carradice, Duncan, Peter Shuttleworth, Jeffrey Szer, Andrew Roberts, and Andrew Grigg. "Tissue Iron Overload Is Common Post Transplantation (Allo BMT) and Is Associated with Red Cell Transfusion Load and HFE Genotype." Blood 104, no. 11 (2004): 2262. http://dx.doi.org/10.1182/blood.v104.11.2262.2262.

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Abstract In order to analyse the incidence of iron overload after allo BMT and assess the role of venesection in preventing complications, we retrospectively analysed 168 consecutive patients undergoing allo BMT at our institution from 1998–2003 surviving at least one year. Iron studies were performed routinely pre-BMT, at D100, one & two years post BMT. Iron overload was defined by at least one of the following criteria i)liver biopsy (n=24), one of : a) dry weight iron concentration >80μmol/g; b) iron index >1.9; c) Perl’s stain grade 3 or 4, ii) CT liver iron >1.0mg/ml (n=13) i

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30

Pecorelli, Anna, Paola Franceschi, Lorenzo Braccischi, Federica Izzo, Matteo Renzulli, and Rita Golfieri. "MRI Appearance of Focal Lesions in Liver Iron Overload." Diagnostics 12, no. 4 (2022): 891. http://dx.doi.org/10.3390/diagnostics12040891.

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Liver iron overload is defined as an accumulation of the chemical element Fe in the hepatic parenchyma that exceeds the normal storage. When iron accumulates, it can be toxic for the liver by producing inflammation and cell damage. This can potentially lead to cirrhosis and hepatocellular carcinoma, as well as to other liver lesions depending on the underlying condition associated to liver iron overload. The correct assessment of liver iron storage is pivotal to drive the best treatment and prevent complication. Nowadays, magnetic resonance imaging (MRI) is the best non-invasive modality to de

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31

Kohgo, Yutaka. "2. Iron Metabolism and Iron Overload." Nihon Naika Gakkai Zasshi 100, no. 9 (2011): 2412–24. http://dx.doi.org/10.2169/naika.100.2412.

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32

Kohgo, Yutaka. "2. Iron Metabolism and Iron Overload." Nihon Naika Gakkai Zasshi 100, Suppl (2011): 46a—50a. http://dx.doi.org/10.2169/naika.100.46a.

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33

Andrews, Nancy C. "IRONMETABOLISM: Iron Deficiency and Iron Overload." Annual Review of Genomics and Human Genetics 1, no. 1 (2000): 75–98. http://dx.doi.org/10.1146/annurev.genom.1.1.75.

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34

Pietrangelo, Antonello. "Iron chelation beyond transfusion iron overload." American Journal of Hematology 82, S12 (2007): 1142–46. http://dx.doi.org/10.1002/ajh.21101.

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35

Beutler, Ernest, A. Victor Hoffbrand, and James D. Cook. "Iron Deficiency and Overload." Hematology 2003, no. 1 (2003): 40–61. http://dx.doi.org/10.1182/asheducation-2003.1.40.

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Abstract In the past seven years numerous genes that influence iron homeostasis have been discovered. Dr. Beutler provides a brief overview of these genes, genes that encode HFE, DMT-1, ferroportin, transferrin receptor 2, hephaestin, and hepcidin to lay the groundwork for a discussion of the various clinical forms of iron storage disease and how they differ from one another. In Section I, Dr. Beutler also discusses the types of hemochromatosis that exist as acquired and as hereditary forms. Acquired hemochromatosis occurs in patients with marrow failure, particularly when there is active inef

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36

Chai, Xiao, Deguan Li, Mingfeng Zhao, et al. "ROS-Mediated Iron Overload Injures The Hematopoiesis Of Bone Marrow By Damaging Hematopoietic Stem/Progenitor Cells In Mice." Blood 122, no. 21 (2013): 962. http://dx.doi.org/10.1182/blood.v122.21.962.962.

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Abstract A substantial portion of patients with inherited blood disorders such as beta thalassemia, or bone marrow failure syndromes such as aplastic anemia(AA), myelodysplastic syndromes(MDS) require frequent transfusions of red blood cells. Frequent blood transfusions may lead to the excess of plasma non-transferrin -bound iron(NTBI) and iron overload occurs, which will significantly injure bone marrow (BM) function as well as induce organ dysfunctions such as liver cirrhosis, diabetes and cardiac diseases. However, the exact mechanism behind this effect remains elusive and ideal treatment n

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37

Kidd, James M., Kamilia Abdelraouf, and David P. Nicolau. "1553. Human-Simulated Pharmacokinetic Profiles of Cefiderocol and Meropenem Are Conserved in Murine Models of Thigh Infection With or Without Iron Overload." Open Forum Infectious Diseases 6, Supplement_2 (2019): S567. http://dx.doi.org/10.1093/ofid/ofz360.1417.

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Abstract Background A translational murine model of thigh infection with comorbid iron overload was previously developed to study the efficacy of iron-dependent siderophore-antibiotic conjugates under conditions where the hypoferremic response of innate immunity may be compromised. Given the potential for functional organ damage from excessive tissue iron, which could alter the pharmacokinetic (PK) profiles of antibiotics being compared for efficacy using this model, the effects of iron overload on a siderophore-β-lactam conjugate, cefiderocol (CFDC), and a non-siderophore β-lactam, meropenem

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38

Porto, Graça. "Iron overload and immunity." World Journal of Gastroenterology 13, no. 35 (2007): 4707. http://dx.doi.org/10.3748/wjg.v13.i35.4707.

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39

Piperno, Alberto, Sara Pelucchi, and Raffaella Mariani. "Inherited iron overload disorders." Translational Gastroenterology and Hepatology 5 (April 2020): 25. http://dx.doi.org/10.21037/tgh.2019.11.15.

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40

Sawada, Kenichi. "Iron Deficiency and Overload." Nihon Naika Gakkai Zasshi 99, no. 6 (2010): 1171–72. http://dx.doi.org/10.2169/naika.99.1171.

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41

Fondu, P., and B. Cantinieaux. "Infections And Iron Overload." Acta Clinica Belgica 41, no. 1 (1986): 1–9. http://dx.doi.org/10.1080/22953337.1986.11719117.

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42

Ombiga, John, Leon A. Adams, Kevin Tang, Debbie Trinder, and John K. Olynyk. "Screening forHFEand Iron Overload." Seminars in Liver Disease 25, no. 04 (2005): 402–10. http://dx.doi.org/10.1055/s-2005-923312.

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43

Jensen, Peter-D. "Evaluation of iron overload." British Journal of Haematology 124, no. 6 (2004): 697–711. http://dx.doi.org/10.1111/j.1365-2141.2004.04838.x.

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44

Sevtsuk, O., and V. Gordeuk. "Iron overload in Estonia." European Journal of Haematology 53, no. 2 (2009): 121–22. http://dx.doi.org/10.1111/j.1600-0609.1994.tb01876.x.

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45

Andrews, Nancy C. "Inherited iron overload disorders." Current Opinion in Pediatrics 12, no. 6 (2000): 596–602. http://dx.doi.org/10.1097/00008480-200012000-00015.

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46

ADAMS, P. C. "Iron overload in Montpelier." Gut 48, no. 6 (2001): 755–56. http://dx.doi.org/10.1136/gut.48.6.755.

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47

Hershko, Chaim, Gabriela Link, Abraham Konijn, and Z. Ioav Cabantchik. "Iron overload and chelation." Hematology 10, sup1 (2005): 171–73. http://dx.doi.org/10.1080/10245330512331390294.

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48

Pietrangelo, Antonello, Angela Caleffi, and Elena Corradini. "Non-HFEHepatic Iron Overload." Seminars in Liver Disease 31, no. 03 (2011): 302–18. http://dx.doi.org/10.1055/s-0031-1286061.

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49

Niederau, Claus. "Iron Overload and Atherosclerosis." Hepatology 32, no. 3 (2000): 672–74. http://dx.doi.org/10.1053/jhep.2000.17921.

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50

Richter, Goetz W. "Studies of Iron Overload." Pathology - Research and Practice 181, no. 2 (1986): 159–67. http://dx.doi.org/10.1016/s0344-0338(86)80005-x.

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