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Zhang, Huan, Xiaoping Gao, Hui Liang, and Yi Ren. "Incomplete stent apposition of low-profile visualized intraluminal support stents in the treatment of cerebral aneurysms." Journal of NeuroInterventional Surgery 12, no. 6 (December 9, 2019): 591–97. http://dx.doi.org/10.1136/neurintsurg-2019-015505.
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ObjectiveThis study retrospectively analyzed the risk factors, management strategies, and complications of incomplete stent apposition (ISA) of low-profile visualized intraluminal support (LVIS) stents after initial deployment in the treatment of cerebral aneurysms.MethodsThe clinical characteristics of ISA or wall apposition (WA) of LVIS stent after initial deployment were analyzed. The risk factors of ISA were identified using univariate logistic regression analysis and multivariate logistic regression analysis. The clinical characteristics of ISA following different management strategies were also shown.ResultsThe retrospective study enrolled 303 patients with 315 LVIS stent-assisted aneurysms. Fifty-nine patients with 59 stents showed ISA after initial deployment. At the end of the study, the presence of ISA was only observed in eight patients (2.5%). The stent-subtended arc angle (>90) and the aneurysm of the internal carotid artery (ICA) were associated with ISA. The stent-subtended arc angle (>90) and stent size (4.5*20 mm) were independent risk factors of ISA. The incidence of thromboembolic events in the ISA group was significantly higher than that in the WA group. After the treatment of ISA, there was no significant difference in good outcomes between patients with ISA and those with WA after initial deployment.ConclusionsISA is more likely to occur at tortuous vessels. The stent-subtended arc angle (>90) and LVIS size (4.5*20 mm) were independent risk factors of ISA. ISA led to significantly increased incidence of thromboembolic events. However, ISA after initial deployment did not affect the patient's prognosis.
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Miles, Kate, and Luke Nottage. "“Back to the Future” for Investor–State Arbitrations: Revising Rules in Australia and Japan to Meet Public Interests." Journal of International Arbitration 26, Issue 1 (February 1, 2009): 25–58. http://dx.doi.org/10.54648/joia2009002.
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The more things change, the more some stay the same. This article first highlights renewed concerns about delays and, especially, costs in international commercial arbitration (ICA). Many now urge quite radical solutions to make ICA more efficient, including allowing parties to authorize arbitrators to facilitate settlement (Arb–Med). At the same time, there are growing calls for more transparency, non–party participation, and other rule changes to promote the legitimacy of the burgeoning field of investor–state arbitration (ISA). Such reforms are justified by the greater variety of public interests involved in ISA, despite some possible losses in efficiency. We should resist a tendency simply to extend the solutions devised or proposed for ICA, particularly in the form of Rules of arbitral institutions, to contemporary ISA.However, some reforms incorporating proper safeguards may also be advisable in both fields, such as Arb–Med processes, or arbitrator remuneration providing better incentives to streamline proceedings. Many reforms can be implemented by institutions devising tailored ISA Rules, to be added as options for investors in bilateral or regional investment treaties or Free Trade Agreements (FTAs). Our article therefore proposes a variety of improvements. These are based on comparisons of the main Rules adopted for ISA (ICSID and the UNCITRAL Rules), the arbitration Rules of institutions like the Australian Centre for International Commercial Arbitration (ACICA) and the Japan Commercial Arbitration Association ( JCAA), and some of the provisions already found in Australia’s FTAs or governing trade disputes under the World Trade Organization (WTO) system. Hopefully, these improvements will enable ISA to keep developing through bilateral initiatives such as the proposed Australia–Japan FTA, emerging regional initiatives, and ultimately a new multilateral framework for investment. Although reforms are currently needed to bolster the legitimacy of ISA, longer–term reforms may instead re–emphasize efficiency, rather like ICA has done after decades spent achieving global acceptance.
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Cedeño Sares, Luis A., Raúl Díaz-Torres, Alicia Casariego-Año, Daniel Arias-Toro, and María Yánez-Romero. "Efecto de la acetilación sobre propiedades físicas del almidón de Banano (M. Sapientum L.) variedad Cavendish." Cumbres 7, no. 1 (June 30, 2021): 9–20. http://dx.doi.org/10.48190/cumbres.v7n1a1.
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El objetivo del presente trabajo fue evaluar la influencia del volumen de anhídrido acético (AA) y tiempo de reacción en el porcentaje de acetilos, grado de sustitución, porcentaje del poder de hinchamiento, índice de solubilidad en agua e índice de absorción de agua del almidón acetilado. Para ello se evaluó la influencia del volumen del anhídrido acético (5, 10, 15 ml) y el tiempo de reacción (30, 60 y 90 min) sobre el porcentaje de acetilo (PA), grado de sustitución (GS), poder de hinchamiento (PH), índice de solubilidad en agua (ISA) e índice de absorción de agua del almidón (IAA).
El volumen de anhídrido acético influyó significativamente en PA, GS, PH, ISA e IAA; mientras que el tiempo de reacción solo influyó significativamente en el PA, GS e ISA (p≥ 0.05). Sin embargo, la interacción entre ambas variables incidió significativamente (p≤ 0.05) en el PH, ISA e IAA (p≤ 0.05). La superficie del granulo presentó ligeros daños al incrementar el volumen de anhidro acético y el tiempo de reacción. El valor del coeficiente de regresión R2 indicó que los modelos ajustados explicaron entre el 99,8929 % y el 97,9964 % la variabilidad de las variables de respuesta.
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&NA;. "ISA 247." Drugs in R & D 8, no. 2 (2007): 103–12. http://dx.doi.org/10.2165/00126839-200708020-00005.
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Schneider, Christiane. "ISA GENZKEN." Afterall: A Journal of Art, Context and Enquiry 2 (January 2000): 27–37. http://dx.doi.org/10.1086/aft.2.20711400.
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McIntyre, J. A., and J. Castañer. "ISA-247." Drugs of the Future 29, no. 7 (2004): 680. http://dx.doi.org/10.1358/dof.2004.029.07.819884.
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Blem, Emily, Jaikrishnan Menon, Thiruvengadam Vijayaraghavan, and Karthikeyan Sankaralingam. "ISA Wars." ACM Transactions on Computer Systems 33, no. 1 (March 11, 2015): 1–34. http://dx.doi.org/10.1145/2699682.
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Tsiklauri-Shengelia, Zhuzhuna, Natia Shengelia, and Revaz Shengelia. "Some Practical Financial Reporting (IFRS) Assessment Aspects Of The Covid-19 Impact on Business." PIRETC-Proceeding of The International Research Education & Training Centre 104, no. 1-2 (April 4, 2021): 76–87. http://dx.doi.org/10.36962/ecs104/1-2-76.
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Generally, the covid-19 pandemic has a great impact on all big, small and medium-sized business all over the world. There are analyzed International Financial Reporting Standards (IFRS) practical issues that should be considered and addressed by the top management. These financial key issues include discussing the following: IFRS 9-Financial Instruments, IAS 36 Impairment of Assets, IAS 1, IAS 2, ISA 570 (revised) -Going Concern . The Impairment Review of Inventory, Fixed Assets, financial instruments, also the Going Concern at the entity level must be assessed in detail in the pandemic and other difficult circumstances; Keywords: IFRS , Covid-19 Impact, Impairment, Expected Credit Loss (ECL), NRV, ISA, Going Concern.
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Malhotra, Naveen. "Increased publication avenues-The ISA--IJA zonal supplements." Indian Journal of Anaesthesia 64, no. 15 (2020): 160. http://dx.doi.org/10.4103/ija.ija_1075_20.
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Chi, Manjiao, and Xi Wang. "The Evolution of ISA Clauses in Chinese IIAs and Its Practical Implications." Journal of World Investment & Trade 16, no. 5-6 (November 13, 2015): 869–98. http://dx.doi.org/10.1163/22119000-01606004.
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China has concluded a large number of international investment agreements (IIAs), many of which include investor-State arbitration (ISA) clauses. These clauses can be divided in three types: narrow, broad and special ISA sections, each providing different admissibility requirements on disputes for ISA. While narrow ISA clauses allow disputes involving the amount of compensation for expropriation to be submitted to ISA, broad ISA clauses and special ISA sections generally allow a wider range of disputes for ISA. The evolution of the ISA clauses shows China’s shifting attitudes towards ISA from ‘cautious’ to ‘proactive’. Such shift seems in favor of ISA and investors, but the impact of this shift remains to be seen.
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Finn, Greg, Sandrine Macé, Ruiyin Chu, Helgi van de Velde, Samia Menad, Marie-Thérèse Melki, and Georges Nouadje. "Development of a Hydrashift 2/4 Isatuximab Assay to Mitigate Interference with Monoclonal Protein Detection on Immunofixation Electrophoresis in Vitro Diagnostic Tests in Multiple Myeloma." Blood 136, Supplement 1 (November 5, 2020): 15. http://dx.doi.org/10.1182/blood-2020-136613.
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Introduction Evaluation of multiple myeloma (MM) response through quantification of M-protein, by serum protein electrophoresis (SPEP) and immuno-fixation electrophoresis (IFE) is challenging for clinical laboratories because therapeutic monoclonal antibodies (mAbs) can confound IFE when they converge with serum M-protein. This can be misleading when interpreting patients' response to therapy. Isatuximab (Isa), an IgG-kappa anti-CD38 mAb is approved based on the pivotal ICARIA-MM study in combination with pomalidomide (P) and dexamethasone (d), in the United States, the European Union, Canada, Australia, Switzerland and Japan for the treatment of adult patients with relapsed/refractory MM who have received at least two prior therapies including lenalidomide and a proteasome inhibitor. Recently, the Phase 3 IKEMA study evaluating Isa plus carfilzomib (K) and d met its primary endpoint at the first planned interim analysis, demonstrating significantly prolonged progression free survival (PFS) compared with Kd alone in patients with relapsed MM. Methods To overcome the interference mediated by Isa on the IFE test, we have developed an Isa-specific assay "HYDRASHIFT 2/4 Isa" using a highly specific rabbit, anti-Isa mAb. The HYDRASHIFT 2/4 Isa test is used in conjunction with the regular Hydragel IF procedure and the semi-automated Hydrasys 2 electrophoresis apparatus. The HYDRASHIFT 2/4 Isa test displaces Isa (IgG kappa) interference during the electrophoresis process by forming Isa/anti-Isa complex which is moved out of the gamma zone toward the alpha globulin fractions. Results: Sensitivity of the HYDRASHIFT 2/4 Isa assay was demonstrated on serum samples, including normal serum samples. Isa control and serum samples with different monoclonal components spiked with Isa (final concentrations in the range of 0.1 and 3.0 g/L) were analyzed with the HYDRASHIFT 2/4 Isa procedure used in conjunction with Hydragel 4 IF Acid Violet. The detection limit of Isa and/or the Isa / anti-Isa antibody complex visualized was 0.2 g/L. Importantly, efficient removal of Isa from the gamma globulin zone, with no trace signal evident, was demonstrated for all Isa concentrations tested, even for 3 g/L. Reproducibility of the HYDRASHIFT 2/4 Isa assay was also demonstrated between gels, between product lots, between instruments and on different test days. Ten different serum samples, including 1 normal serum sample and 9 serum samples with monoclonal components spiked with Isa at 1 g/L, were run using the HYDRASHIFT 2/4 Isa procedure in conjunction with Hydragel 4 IF Acid Violet. All samples gave 100% concordant results between gels on the different instruments and with different HYDRASHIFT 2/4 Isa lots. To evaluate specificity, 50 serum samples from MM patients were spiked with 1 g/L Isa and the anti-Isa mAb shifted Isa specifically with no impact on the patients' M-spike, demonstrating 100% specificity. Finally, the HYDRASHIFT 2/4 Isa test was evaluated on 15 samples from treated patients enrolled in Isa clinical trials at different therapy cycles. The evaluated samples demonstrated efficient removal of Isa from G and Kappa tracks on the gamma globulins zone and visualization of the Isa/anti-Isa complex on alpha zone and/or Isa on ELP track. For the pre-treatment samples, there was as expected no Isa detection, and no impact on M-protein was observed, further confirming the specificity of the assay toward Isa. Conclusions Therapeutic mAb inclusion in MM treatment regimens offer patients significant improvements in clinical outcomes. With rapid evolution of therapeutic options in MM, there is a clear need for a standardized and reliable method to ensure authentic IFE-based clinical assessment. Development of the Isa-specific HYDRASHIFT 2/4 Isa assay offers the advantage of high clinical utility due to the simplicity of the method as an add-on to the conventional IFE In vitro diagnostic test. Consequently, this assay will facilitate the correct assessment of clinical outcomes for patients receiving Isa as part of their MM treatment. Submission for global regulatory clearance for Isa-specific HYDRASHIFT 2/4 assay is planned in 2020. Disclosures Finn: Sanofi: Current Employment. Macé:Sanofi: Current Employment. Chu:Sanofi: Current Employment. van de Velde:Sanofi: Current Employment, Current equity holder in publicly-traded company. Melki:Sebia: Current Employment.
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Ocaña, J., P. Pastor-Peinado, P. Abadía, A. Ballestero, D. Ramos, JC García-Pérez, JM Fernández-Cebrián, and J. Die. "Risk Factors for Anastomotic Leakage Following Total or Subtotal Colectomy." Journal of Coloproctology 42, no. 01 (January 17, 2022): 038–46. http://dx.doi.org/10.1055/s-0041-1740207.
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Abstract Introduction A higher rate of anastomotic leakage (AL) is reported after ileosigmoid anastomosis (ISA) or ileorectal anastomosis (IRA) in total or subtotal colectomy (TSC) compared with colonic or colorectal anastomosis. The main aim of the present study was to assess potential risk factors for AL after ISA or IRA and to investigate determinants of morbidity. Methods We identified 180 consecutive patients in a prospective referral, single center database, in which 83 of the patients underwent TSC with ISA or IRA. Data regarding the clinical characteristics, surgical treatment, and outcome were assessed to determine their association with the cumulative incidence of AL and surgical morbidity. Results Ileosigmoid anastomosis was performed in 51 of the patients (61.5%) and IRA in 32 patients (38.6%). The cumulative incidence of AL was 15.6% (13 of 83 patients). A higher AL rate was found in patients under 50 years-old (p = 0.038), in the elective-laparoscopic approach subgroup (p = 0.049), and patients in the inflammatory bowel disease (IBD) subgroup (p = 0.009). Furthermore, 14 patients (16.9%) had morbidity classified as Clavien-Dindo ≥ IIIA. Discussion A relatively high incidence of AL after TSC was observed in a relatively safe surgical procedure. Our findings suggest that the risk of AL may be higher in IBD patients. According to our results, identifying risk factors prior to surgery may improve short-term outcomes.
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Ibrahim, Ehab El-Sayed, Wael Mossad Gamal, Amr Ismail Hassan, Safy El-Din Mahdy, Akram Zakria Hegazy, and Magdy Mahmoud Abdel-Atty. "Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine." Veterinary World 8, no. 10 (October 2015): 1189–98. http://dx.doi.org/10.14202/vetworld.2015.1189-1198.
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Muhammad, Hasyim. "KEZUHUDAN ISA AL-MASIH DALAM KITAB AL-ZUHD WA’L-RAQĀ’IQ DAN AL-ZUHD." Walisongo: Jurnal Penelitian Sosial Keagamaan 20, no. 2 (December 15, 2012): 413. http://dx.doi.org/10.21580/ws.2012.20.2.206.
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<p class="IIABSBARU">The ascetisc of Isa al-Masih is the most polular model in strengtening the ascetism doctrines among tasawwuf experts in clasical periods. At least it was depicted in clasical sunnite sufism that narrated the messages and stories about the escatism of Isa al-Masih. Above all, the more valid source, i.e. al-Qur’an and al-hadits are more than enough to strengten the doctrine of ascetism for the tasawwuf experts (sufi). Ascetism of Isa al-Masih was conformable to the concept of ascetismof the sufi, which meant that have nothing and belong to nothing (lā yamliku shaian walā yamlikuhu shaiun). Ascetism is not only merely spiritual position which is depicted in tasawuf, but ascetisme in this context is the spiritual it self.</p><p class="IKa-ABSTRAK">***</p>Asketisme Isa al-Masih merupakan model yang paling populer dalam memperkuat doktrin asketisme di kalangan ahli tasawuf dalam periode klasik. Setidaknya itu digambarkan dalam sufisme sunni klasik yang menarasikan pesan dan kisah mengenai asketisme Isa al-Masih. Di luar itu semua, sumber yang lebih valid, yaitu al-Qur’an dan hadits lebih dari cukup untuk memperkuat doktrin asketisme bag para ahli tasawuf (sufi). Asketisme Isa al-Masih sesuai dengan konsep asketisme sufi yang artinya tidak memiliki apa-apa dan bukan milik siapa-siapa (<em>lā yamliku </em><em>shaian </em><em>walā yamliku </em><em>shaiun</em>). Asketisme bukan sekedar posisi spiritual yang digambarkan di dalam tasawuf, tetapi asketisme dalam konteks ini adalah spiritual itu sendiri.
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Brecher, Michael. "ISA Presidential Address." International Studies Quarterly 43, no. 2 (June 1999): 213–64. http://dx.doi.org/10.1111/0020-8833.00119.
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Venkat, Ashish, and Dean M. Tullsen. "Harnessing ISA diversity." ACM SIGARCH Computer Architecture News 42, no. 3 (October 16, 2014): 121–32. http://dx.doi.org/10.1145/2678373.2665692.
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BLENKINSOP, T. "Mount Isa inlier." Precambrian Research 163, no. 1-2 (May 20, 2008): 1–6. http://dx.doi.org/10.1016/j.precamres.2007.08.009.
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Andrade, Adriana García. "ISA Web Forum." Bulletin of Sociological Methodology/Bulletin de Méthodologie Sociologique 130, no. 1 (March 22, 2016): 102–5. http://dx.doi.org/10.1177/0759106315627741d.
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Betts, P. G., and B. R. Goleby. "Mt Isa tectonics." Australian Journal of Earth Sciences 53, no. 1 (February 2006): 1–3. http://dx.doi.org/10.1080/08120090500431407.
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Kim, Kihyun, Chang Ki Min, Youngil Koh, Kenichi Ishizawa, Sung-Hyun Kim, Shigeki Ito, Tanaka Junji, et al. "Isatuximab plus carfilzomib and dexamethasone in east Asian patients with relapsed multiple myeloma: IKEMA subgroup analysis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e20015-e20015. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e20015.
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e20015 Background: The Phase 3 IKEMA study (NCT03275285) demonstrated that isatuximab (Isa) plus carfilzomib and dexamethasone (Kd) significantly improved progression-free survival (PFS) compared with Kd in patients (pts) with relapsed multiple myeloma (RMM) (hazard ratio [HR] 0.53; 99% confidence interval [CI] 0.32–0.89; P= 0.0007). We evaluated the efficacy and safety of Isa-Kd in the East Asian patients (19 Japanese, 27 Korean). Methods: RMM pts who received 1-3 prior lines of therapy were stratified to receive Isa-Kd or Kd. Isa-Kd arm received Isa (10 mg/kg intravenously) weekly for 4 weeks, then every 2 weeks. Both arms received K (20 mg/m2 days 1-2, 56 mg/m2 thereafter) twice-weekly for 3 of 4 weeks, and d (20 mg) twice-weekly. Treatment continued until disease progression or unacceptable adverse events (AE). The primary endpoint was prolongation of PFS. Key secondary endpoints included; very good partial response or better (≥VGPR), complete response (CR) rate and minimal residual disease negativity (MRD–) rate. Results: East Asian pts (25 Isa-Kd, 21 Kd) were randomized. Pt characteristics were similar in the East Asian subgroup compared with the intent to treat (ITT) population (N = 302). Median age (Isa-Kd 64.0 [range 45–83] years vs Kd 60.0 [range 33–73] years); median prior lines Isa-Kd 2.0 (range 1–3) vs Kd 1.0 (range 1–3); refractory to lenalidomide 16.0% Isa-Kd vs 47.6% Kd; refractory to PI 20.0% Isa-Kd vs 33.3% Kd; high-risk cytogenetics 48.0% Isa-Kd vs 42.9% Kd. After a median follow-up of 20.7 months, the addition of Isa to Kd improved ≥VGPR, CR and MRD– rates (Table). The HR 0.64 (95%CI: 0.231-1.764) for disease progression or death favored Isa-Kd. Grade ≥3 AEs were observed in 79.2% Isa-Kd vs 55.0% Kd pts, serious TEAEs in 45.8% Isa-Kd vs 50.0% Kd; TEAEs leading to treatment discontinuation were lower in the Isa-Kd group (4.2% Isa-Kd vs 10.0% Kd). Overall, 64.0% Isa-Kd vs 42.9% Kd pts were still receiving treatment. Conclusions: Efficacy and safety results of Isa-Kd in East Asian pts are consistent with the results of the overall IKEMA population, in which significantly better efficacy (PFS, CR, ≥VGPR and MRD– rate) was reported in favor of Isa-Kd without an increase in the number of patients with serious TEAEs or discontinuations. Isa-Kd is a potential treatment option for East Asian pts with RMM. Clinical trial information: NCT03275285. [Table: see text]
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Soglin, Lenore Fitzsimmons, Maya Ragavan, Supriya Immaneni, and David F. Soglin. "Assessing Intimate Partner Violence in South Asian Women Using the Index of Spouse Abuse." Violence Against Women 26, no. 6-7 (May 3, 2019): 697–711. http://dx.doi.org/10.1177/1077801219842945.
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Intimate Partner Violence (IPV) affects 21-40% of South Asian (SA) women in the United States. No screening tool has been validated in this population. This study sought to determine the validity of the Index of Spouse Abuse (ISA) as an IPV screening tool and to determine the prevalence of IPV among a SA immigrant population. Thirty-one percent of women screened positive on one or both ISA scales. The ISA-P and ISA-NP items were highly reliable as was the correlation between the ISA-P and ISA-NP scores. The ISA is a valid and reliable IPV screening tool in the SA immigrant population.
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Atwood, Preston L. "The Peshiṭta of Isaiah in Past and Present Scholarship." Currents in Biblical Research 18, no. 3 (May 20, 2020): 211–45. http://dx.doi.org/10.1177/1476993x19850045.
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In this study I outline the scholarship pertaining to the Peshiṭta of Isaiah (S-Isa) and expound on specific topics in need of further research. I begin by recounting the process of S-Isa’s manuscript collation and its culmination in Leiden’s editio minor. Relatedly, I explain the role of citations in the patristic literature for reconstructing the original text of S-Isa. Then, I address how scholars approach the question of S-Isa’s relation to the Old Greek (G-Isa) and Targum (T-Isa) of Isaiah. I move on to summarize the studies on the translation technique of S-Isa and explain how they have aided in determining the degree to which S-Isa may have been influenced by G- and T-Isa. I continue by adumbrating the debate on the authorship and theology of S-Isa and problematizing certain assumptions brought to the discussion. I conclude by offering a few reflections on the future of S-Isa scholarship.
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Shah, Bahramand, Gohar Rahman, and Sana Riaz. "The Application of Althusser's theory of ISA in E. M. Foster's Novel "A Passage to India"." Global Political Review VI, no. I (June 30, 2021): 164–74. http://dx.doi.org/10.31703/gpr.2021(vi-ii).19.
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ISA stands for Ideological State Apparatus. It includes several ISAs i.e. Educational ISA, Religious ISA, Political ISA, Social and Cultural ISA, Media ISA, etc. The novel “A Passage to India by E.M Foster” is a good example of these ISAs. This novel is based on the subject of orientalism, colonialism, and British rule. It discloses the stereotypical image of the Orientals and the continuous process of constructing or brainwashing to which newcomers are subjected, to generate colonizers who are all the same. This study aims to discuss political and religious ISAs in the novel “A Passage to India” by E. M Foster. Further, this research is also based on the application of religious and Political domains of ISA, the study of the relation of ISA with colonialism, and the study of the effects of ideology on society.
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Melssen, Marit M., Caroline T. Fisher, Craig L. Slingluff, and Cornelis J. M. Melief. "Peptide emulsions in incomplete Freund’s adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of cancer." Journal for ImmunoTherapy of Cancer 10, no. 9 (September 2022): e004709. http://dx.doi.org/10.1136/jitc-2022-004709.
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Water-in-oil emulsion incomplete Freund’s adjuvant (IFA) has been used as an adjuvant in preventive and therapeutic vaccines since its development. New generation, highly purified modulations of the adjuvant, Montanide incomplete seppic adjuvant (ISA)-51 and Montanide ISA-720, were developed to reduce toxicity. Montanide adjuvants are generally considered to be safe, with adverse events largely consisting of antigen and adjuvant dose-dependent injection site reactions (ISRs). Peptide vaccines in Montanide ISA-51 or ISA-720 are capable of inducing both high antibody titers and durable effector T cell responses. However, an efficient T cell response depends on the affinity of the peptide to the presenting major histocompatibility complex class I molecule, CD4+ T cell help and/or the level of co-stimulation. In fact, in the therapeutic cancer vaccine setting, presence of a CD4+ T cell epitope seems crucial to elicit a robust and durable systemic T cell response. Additional inclusion of a Toll-like receptor ligand can further increase the magnitude and durability of the response. Use of extended peptides that need a processing step only accomplished effectively by dendritic cells (DCs) can help to avoid antigen presentation by nucleated cells other than DC. Based on recent clinical trial results, therapeutic peptide-based cancer vaccines using emulsions in adjuvant Montanide ISA-51 can elicit robust antitumor immune responses, provided that sufficient tumor-specific CD4+ T cell help is given in addition to CD8+ T cell epitopes. Co-treatment with PD-1 T cell checkpoint inhibitor, chemotherapy or other immunomodulatory drugs may address local and systemic immunosuppressive mechanisms, and further enhance efficacy of therapeutic cancer peptide vaccines in IFA and its modern variants. Blinded randomized placebo-controlled trials are critical to definitively prove clinical efficacy. Mineral oil-based adjuvants for preventive vaccines, to tackle spread and severity of infectious disease, induce immune responses, but require more studies to reduce toxicity.
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Sihn, Duho, and Sung-Phil Kim. "Differential modulation of behavior by infraslow activities of different brain regions." PeerJ 10 (February 1, 2022): e12875. http://dx.doi.org/10.7717/peerj.12875.
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The oscillation phase of electroencephalograms (EEGs) is associated with behavioral performance. Several studies have demonstrated this association for relatively fast oscillations (>1 Hz); a similar finding has also been reported for slower oscillations, showing that behavioral performance is correlated with the phase of infraslow activity (ISA, 0.01–0.1 Hz) of electroencephalography (EEG). However, the previous study only investigated ISA in a local brain region using a relatively simple task (somatosensory discrimination task), leaving it difficult to determine how the EEG ISA for various brain regions is associated with behavioral performance. In addition, it is not known whether the EEG ISA phase modulates more complex behavioral task performance. In the present study, we analyzed the ISA of whole-brain EEG of participants performing various behaviors while playing video games. We found that behavior was associated with the specific oscillation phase of EEG ISA when that behavior was independent of other behaviors. In addition, we found that the EEG ISA oscillation phases modulating the different behaviors varied across brain regions. Our results suggest that the EEG ISA for different brain regions modulates behavioral performance in different ways and such modulation of EEG ISA can be generalized to diverse behaviors. This study may deepen the understanding of how EEG ISA modulates behavior and increases the applicability of EEG ISA.
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KIRCHHEVEL, GORDON D. "He That Cometh in Mark 1:7 and Matt 24:30." Bulletin for Biblical Research 4, no. 1 (January 1, 1994): 105–11. http://dx.doi.org/10.2307/26422105.
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Abstract According to Mark 1:7 John the Baptist expected the coming of someone perceived as predicted in Isa 5:26–27. According to Matt 24:30 Jesus expected to come as the individual perceived in Isa 5:26–30 and the Targum (Aramaic interpretation), and so the "sign" of his coming meant the "sign" in Isa 5:26, and the "clouds" meant the "clouds" in Isa 5:30 and Targumic tradition. Messianic Isa 11:10 and Aramaic tradition inspired John 14:2– 3, and Mark 13:27 coheres dictionally with Tg. Isa 11:12. The messianic interpretation of Psalm 8 in Mark 2:10, 28 was preceded by one in 1 Cor 15:27, and the messianic interpretation of Isa 5:26–30 in Mark 13:26 was preceded by one in 1 Thess 4:13–18 ("the word of the Lord" = Isa 5:26–30).
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KIRCHHEVEL, GORDON D. "He That Cometh in Mark 1:7 and Matt 24:30." Bulletin for Biblical Research 4, no. 1 (January 1, 1994): 105–11. http://dx.doi.org/10.5325/bullbiblrese.4.1.0105.
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Abstract According to Mark 1:7 John the Baptist expected the coming of someone perceived as predicted in Isa 5:26–27. According to Matt 24:30 Jesus expected to come as the individual perceived in Isa 5:26–30 and the Targum (Aramaic interpretation), and so the "sign" of his coming meant the "sign" in Isa 5:26, and the "clouds" meant the "clouds" in Isa 5:30 and Targumic tradition. Messianic Isa 11:10 and Aramaic tradition inspired John 14:2– 3, and Mark 13:27 coheres dictionally with Tg. Isa 11:12. The messianic interpretation of Psalm 8 in Mark 2:10, 28 was preceded by one in 1 Cor 15:27, and the messianic interpretation of Isa 5:26–30 in Mark 13:26 was preceded by one in 1 Thess 4:13–18 ("the word of the Lord" = Isa 5:26–30).
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Bolcato, Léa, Anne Thiebaut-Bertrand, Françoise Stanke-Labesque, and Elodie Gautier-Veyret. "Variability of Isavuconazole Trough Concentrations during Longitudinal Therapeutic Drug Monitoring." Journal of Clinical Medicine 11, no. 19 (September 28, 2022): 5756. http://dx.doi.org/10.3390/jcm11195756.
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Isavuconazole (ISA), a triazole antifungal agent, is licensed for the treatment of invasive aspergillosis and mucormycosis. Therapeutic drug monitoring (TDM) is a cornerstone of treatment efficacy for triazole antifungals due to their pharmacokinetic variability, except for ISA, for which the utility of TDM is still uncertain. We performed a retrospective study that aimed to assess the inter- and intra-individual variability of ISA trough concentrations (Cmin) and to identify the determinants involved in such variability. ISA Cmin measured in adult patients at the Grenoble Alpes University Hospital between January 2018 and August 2020 were retrospectively analyzed. In total, 304 ISA Cmin for 33 patients were analyzed. The median ISA Cmin was 2.8 [25th–75th percentiles: 2.0–3.7] mg/L. The inter- and intra-individual variability was 41.5% and 30.7%, respectively. Multivariate analysis showed independent covariate effects of dose (β = 0.004 ± 3.56 × 10−4, p < 0.001), Aspartate aminotransférase (ASAT) (β = 0.002 ± 5.41 × 10−4, p = 0.002), and protein levels (β = 0.022 ± 0.004, p < 0.001) on ISA Cmin, whereas C reactive protein levels did not show any association. This study, conducted on a large number of ISA Cmin, shows that ISA exposure exhibits variability, explained in part by the ISA dose, and ASAT and protein levels.
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Lillehoj, Hyun, Sung Hyen Lee, Laurent Dupuis, and Juliette Ben Arous. "Evaluation of Montanide™ ISA 71 VG adjuvant against coccidiosis (VET2P.1030)." Journal of Immunology 192, no. 1_Supplement (May 1, 2014): 207.2. http://dx.doi.org/10.4049/jimmunol.192.supp.207.2.
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Abstract Chickens were immunized subcutaneously with an Eimeria recombinant profilin protein plus MontanideTM ISA 70 VG (ISA70) or MontanideTM ISA 71 VG (ISA 71) water-in-oil adjuvants, or with profilin alone. While immunization with profilin/ISA 70 vs. profilin alone altered the levels of more total transcripts compared with profilin/ISA 71 vs. profilin alone (509 vs. 296), the latter was associated with a greater number of unique biological functions, and a larger number of genes within these functions, compared with the former. Canonical pathway analysis identified 10 pathways related with genes encoding the altered transcripts in animals immunized with profilin/ISA 71 vs. profilin alone, compared with only 2 pathways in profilin/ISA 70 vs. profilin alone. Vaccination with profilin/ISA 71 was associated with greater body weight gain following E. acervulina infection, and decreased parasite fecal shedding after E. maxima infection, compared with profilin alone. Anti-profilin antibody levels were higher in sera of E. maxima- and E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone. The levels of transcripts encoding interferon-γ, interleukin (IL)-2, IL-10, and IL-17A were increased in intestinal lymphocytes from E. acervulina-, E. maxima-, and/or E. tenella-infected chickens vaccinated with profilin/ISA 71 compared with profilin alone.
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Shen, Jiaqi, Yanmin Shuai, Peixian Li, Yuxi Cao, and Xianwei Ma. "Extraction and Spatio-Temporal Analysis of Impervious Surfaces over Dongying Based on Landsat Data." Remote Sensing 13, no. 18 (September 14, 2021): 3666. http://dx.doi.org/10.3390/rs13183666.
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It is necessary to understand the relationship between the impervious surface area (ISA) distribution, variation trends and potential driving forces over Dongying, Shandong Province. We extracted ISA information from Landsat images with 3–5 year intervals during 1995 to 2018 using Minimum Noise Fraction (MNF) transform, Pixel Purity Index (PPI), and Linear Spectral Mixture Analysis (LSMA), followed by the analysis on three driving forces of ISA expansion (physical geography, socioeconomic factors, and urban cultural features). Our results show the retrieved ISA thematic map fit the limited requirement of root mean square error (RMSE). The correct classification accuracy of ISA is greater than 83.08%. Further, the cross–comparison exhibits the general consistent with the ISA distribution of the land use classification map published by the National Basic Geographic Information Center. The gradual increasing trend can be captured on the expansion of ISA from 1995 to 2018. Despite of the central region always shown as the high ISA density, it still keeps increasing annually and radiating the surrounding region, especially in the southward which has formed into a new large–scale and high intensity of ISA in 2015–2018. Though the ISA patches scattered in the west region or along the northern and eastern part of the ocean coastline are still small, the expansion trend of ISA can be detected. The expansion intensity index (EII) of ISA measuring the situation of its expansion changes from the lowest value 0.12% between 1995 and 2000 up to the highest 0.73% between 2000 and 2005. Richly endowed by nature, the city’s natural geographical environment provides an elevated chance of further urbanization. The rapid increase of regional economy provides a fundamental driving force for expanding ISAs. The development of urban culture promotes the sustainable development of ISAs. Our results provide a scientific basis for future urban land use management, construction planning, and environmental protection in Dongying.
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Karahalios, Dean G., Taro Kaibara, Randall W. Porter, Udaya K. Kakarla, Phillip M. Reyes, Ali A. Baaj, Ali S. Yaqoobi, and Neil R. Crawford. "Biomechanics of a lumbar interspinous anchor with anterior lumbar interbody fusion." Journal of Neurosurgery: Spine 12, no. 4 (April 2010): 372–80. http://dx.doi.org/10.3171/2009.10.spine09305.
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Object An interspinous anchor (ISA) provides fixation to the lumbar spine to facilitate fusion. The biomechanical stability provided by the Aspen ISA was studied in applications utilizing an anterior lumbar interbody fusion (ALIF) construct. Methods Seven human cadaveric L3–S1 specimens were tested in the following states: 1) intact; 2) after placing an ISA at L4–5; 3) after ALIF with an ISA; 4) after ALIF with an ISA and anterior screw/plate fixation system; 5) after removing the ISA (ALIF with plate only); 6) after removing the plate (ALIF only); and 7) after applying bilateral pedicle screws and rods. Pure moments (7.5 Nm maximum) were applied in flexion and extension, lateral bending, and axial rotation while recording angular motion optoelectronically. Changes in angulation as well as foraminal height were also measured. Results All instrumentation variances except ALIF alone reduced angular range of motion (ROM) significantly from normal in all directions of loading. The ISA was most effective in limiting flexion and extension (25% of normal) and less effective in reducing lateral bending (71% of normal) and axial rotation (71% of normal). Overall, ALIF with an ISA provided stability that was statistically equivalent to ALIF with bilateral pedicle screws and rods. An ISA-augmented ALIF allowed less ROM than plate-augmented ALIF during flexion, extension, and lateral bending. Use of the ISA resulted in flexion at the index level, with a resultant increase in foraminal height. Compensatory extension at the adjacent levels prevented any significant change in overall sagittal balance. Conclusions When used with ALIF at L4–5, the ISA provides immediate rigid immobilization of the lumbar spine, allowing equivalent ROM to that of a pedicle screw/rod system, and smaller ROM than an anterior plate. When used with ALIF, the ISA may offer an alternative to anterior plate fixation or bilateral pedicle screw/rod constructs.
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Desai, Jayesh, Marwan Fakih, Katrina Sophia Pedersen, Yong Sang Hong, Neil Howard Segal, Simon Allen, Lorna Bailey, et al. "Phase Ib/II open-label, randomized evaluation of efficacy and safety of atezolizumab plus isatuximab versus regorafenib in MORPHEUS-colorectal cancer." Journal of Clinical Oncology 39, no. 3_suppl (January 20, 2021): 82. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.82.
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82 Background: The MORPHEUS platform consists of multiple, global, open-label, randomized Phase Ib/II trials designed to identify early efficacy signals and safety of treatment (tx) combinations across tumor types. Isatuximab (isa; anti-CD38) targets CD38 receptors expressed on immunosuppressive cells in the tumor microenvironment. We hypothesized atezolizumab (atezo; anti–PD-L1) + isa would induce an anti-tumor response beyond that of regorafenib (rego), a multi-kinase inhibitor, in patients (pts) with tx-refractory metastatic colorectal cancer (mCRC). Methods: This randomized Phase Ib/II trial (NCT03555149) enrolled pts with microsatellite stable/mismatched repair proficient mCRC who had received ≤ 2 prior tx lines (fluoropyrimidine-, oxaliplatin- or irinotecan-containing chemotherapy plus a biologic agent). Pts received atezo (1200 mg intravenously [IV] every 3 weeks [q3w]) + isa (10 mg/kg IV q3w) or control tx with rego (160 mg orally days 1–21; dose escalation to 160 mg during Cycle 1 allowed per institutional guidelines). The primary endpoint was objective response rate (ORR; investigator-assessed RECIST 1.1); secondary endpoints included progression-free survival (PFS), overall survival (OS), disease control rate (DCR) and safety. Results: Data cutoff date was March 3, 2020. Fifteen pts received atezo + isa and 13 pts received rego. Fourteen atezo + isa pts (93.3%) and 11 control arm pts (84.6%) had received 2 prior lines of tx; 9 atezo + isa pts (60.0%) and 9 control pts (69.2%) had liver metastases at enrollment. No responses were seen in either arm; 3 pts receiving atezo + isa (20.0%) and 8 control pts (61.5%) had stable disease as their best response. DCR (response and/or stable disease ≥ 12 weeks) was 6.7% with atezo + isa and 15.4% with control. One pt treated with atezo + isa beyond progression had prolonged disease stabilization. Median PFS was 1.4 mo (95% CI: 1.4, 1.8) with atezo + isa and 2.8 mo (95% CI: 1.6, 3.1) in the control arm; median OS was 5.1 mo (95% CI: 3.1, 7.8) with atezo + isa and 10.2 mo (95% CI: 4.8, not reached) with control. Tx-related adverse events (AEs, Grade 1-4) occurred in 13 atezo + isa pts (86.7%), and 12 control pts (92.3%). The most common tx-related AEs with atezo + isa were infusion-related reaction (73.3%), nausea (26.7%) and fatigue (20.0%). No Grade 5 AEs occurred in the atezo + isa arm, 1 (7.7%) was reported in the control arm (sepsis, considered unrelated to study tx). No atezo + isa pts and 1 control-arm pt (7.7%) withdrew from treatment due to a tx-related AE. Biomarker analyses did not identify any significant trends related to efficacy. Conclusions: In this trial, superior efficacy of atezo + isa vs rego was not shown. However, the atezo + isa combination was well tolerated, with a manageable safety profile. Clinical trial information: NCT03555149.
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Устинова and Yana Ustinova. "Transition to ISA: Changes in Audit Documentation Practice." Auditor 3, no. 8 (August 28, 2017): 3–14. http://dx.doi.org/10.12737/article_599bf5349770b0.86929014.
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Th e article considers the eff ects of transition to ISA in audit documenting. Th e author analyzes base audit documenting problems, existing before the transition to ISA, discloses ISA specifi c features, refl ected in the change of approach to audit documenting, explores the main results the transition to ISA in formation of auditor working papers.
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Zhang, Yanyi, Yugang Tian, and Lihao Zhang. "A Soil and Impervious Surface Adjusted Index for Urban Impervious Surface Area Mapping." Photogrammetric Engineering & Remote Sensing 87, no. 2 (February 1, 2021): 91–104. http://dx.doi.org/10.14358/pers.87.2.91.
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Index-based methods are widely applied to urban impervious surface area (ISA) mapping, but the confusion between ISA and soil remains unsolved. In this article, the near-infrared (NIR)-blue bands were selected as feature space by analyzing the spectra from the US Geological Survey spectral library, and a simple impervious surface ratio index (ISRI) was developed by shifting the NIR-blue coordinate origin toward the convergence point of the fitting lines of ISA and soil. The ISRI was then validated for threshold simulation, separability, and correlation analysis. Results demonstrated that ISRI had a good performance for ISA mapping in four cities in China with different geographic environments, with all extraction accuracies all above 90%. ISRI had a high separability between ISA and soil and was better than other indices (normalized difference built-up index and biophysical composition index). Further, ISRI has a close relationship with the ISA proportion. Therefore, ISRI would be a simple and reliable index for urban ISA mapping.
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Rook, Arno M., and Jeroen H. Hogema. "Effects of Human–Machine Interface Design for Intelligent Speed Adaptation on Driving Behavior and Acceptance." Transportation Research Record: Journal of the Transportation Research Board 1937, no. 1 (January 2005): 79–86. http://dx.doi.org/10.1177/0361198105193700112.
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The effects of human–machine interface (HMI) design for intelligent speed adaptation (ISA) on driving behavior and acceptance were measured in a moving-base research driving simulator. Sixty-four experienced drivers participated in two simulator experiments (32 in each). During the simulated runs with ISA, the speed limit was communicated through the ISA system. The ISA system consisted of an indication of the speed limit on the speedometer and a gas pedal that could be used either as a haptic or tactile pedal or as a dead throttle. Two versions of the haptic gas pedal were examined in Experiment I: a low-force ISA (easy to overrule, informative in nature) and a high-force ISA (stronger counterforce, more compulsory in nature). Two other configurations were tested in Experiment II: a tactile pedal (a vibration on the gas pedal, informative in nature) and a dead throttle (completely restraining the driver from exceeding the speed limit). It was hypothesized that the closer the ISA is to an informative type, the higher the acceptance and the smaller the effects on driving behavior would be. This hypothesis appeared to be valid, although for both driving behavior and acceptance, not all four HMIs could be ranked unambiguously on the scale from no ISA to full ISA. In sharp curves, drivers appeared to choose a driving speed below the speed limit, irrespective of ISA. The specific road environment scenarios that were inserted to examine presupposed compensatory behavior for experienced delay indicated no signs of compensatory driving behavior.
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Baston, G. M. N., M. M. Cowper, T. G. Heath, T. A. Marshall, and S. W. Swanton. "The effect of cellulose degradation products on thorium sorption onto hematite: studies of a model ternary system." Mineralogical Magazine 76, no. 8 (December 2012): 3381–90. http://dx.doi.org/10.1180/minmag.2012.076.8.51.
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AbstractCellulose degradation products (CDPs) can complex with radioelements causing solubility enhancement and sorption reduction, effects which are detrimental to the containment of radionuclides in the near field of a geological disposal facility and surrounding geosphere. Isosaccharinic acid (ISA) is the principal component of CDPs formed under the alkaline anaerobic conditions of a cement-based near field and appears to be largely responsible for the impact of CDPs on radionuclide solubility and sorption under near-field conditions. However, the situation appears to be more complicated under near-neutral pH geosphere conditions.A combined experimental and modelling study was undertaken to compare the impact of a CDP leachate to ISA in a simple model ternary sorption system consisting of hematite as a single mineral substrate, thorium as the radioelement and ISA or a CDP leachate as the complexant. Thorium sorbs strongly to hematite. A triple layer model for thorium sorption to hematite was refined to fit to the experimental data in the absence of ISA or CDP leachate; the effect of ISA on thorium sorption was then predicted.In the presence of CDP leachate, a significant reduction in thorium sorption was observed from pH 6 to 12 in good agreement with model predictions based on a high concentration of ISA. However, only a limited impact of ISA on thorium sorption was observed at pH 6 to 12, in contrast to predictions. The effects of ISA could be accounted for by assuming the formation of a ternary thorium–ISA–surface complex. The model has yet to be extended to the more complex CDP systems. Differences in the thorium speciation in solution due to the formation of a ternary calcium–thorium–ISA complex in the CDP leachate, which is absent from solutions with ISA only, provides the most likely explanation for the differences observed experimentally.
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Zhang, Youshui, Heiko Balzter, and Yu Li. "Influence of Impervious Surface Area and Fractional Vegetation Cover on Seasonal Urban Surface Heating/Cooling Rates." Remote Sensing 13, no. 7 (March 26, 2021): 1263. http://dx.doi.org/10.3390/rs13071263.
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The urban thermal environment is impacted by changes in urban landscape patterns resulting from urban expansion and seasonal variation. In order to cope effectively with urban heat island (UHI) effects and improve the urban living environment and microclimate, an analysis of the heating effect of impervious surface areas (ISA) and the cooling effects of vegetation is needed. In this study, Landsat 8 data in four seasons were used to derive the percent ISA and fractional vegetation cover (FVC) by spectral unmixing and to retrieve the land surface temperature (LST) from the radiative transfer equation (RTE). The percent ISA and FVC were divided into four different categories based on ranges 0–25%, 25–50%, 50–75%, and 75–100%. The LST with percent ISA and FVC were used to calculate the surface heating rate (SHR) and surface cooling rate (SCR). Finally, in order to analyze the heating effect of ISA and the cooling effect of vegetation, the variations of LST with SHR and SCR were compared between different percent ISA and FVC categories in the four seasons. The results showed the following: (1) In summer, SHR decreases as percent ISA increases and SCR increases as FVC increases in the study area. (2) Unlike the dependence of LST on percent ISA and FVC, the trends of SHR/SCR as a function of percent ISA/FVC are more complex for different value ranges, especially in spring and autumn. (3) The SHR (heating capacity) decreases with increasing percent ISA in autumn. However, the SCR (cooling capacity) decreases with increasing FVC, except in summer. This study shows that our methodology to analyze the variation and change trends of SHR, SCR, and LST based on different ISA and FVC categories in different seasons can be used to interpret urban ISA and vegetation cover, as well as their heating and cooling effects on the urban thermal environment. This analytical method provides an important insight into analyzing the urban landscape patterns and thermal environment. It is also helpful for urban planning and mitigating UHI.
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Facon, Thierry, Philippe Moreau, Thomas G. Martin, Ivan Spicka, Albert Oriol, Youngil Koh, Andrew Lim, et al. "Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in elderly patients with relapsed multiple myeloma: IKEMA subgroup analysis." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 8026. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.8026.
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8026 Background: A prespecified interim efficacy analysis of the Phase 3 IKEMA study (NCT03275285) demonstrated that isatuximab (Isa) plus carfilzomib (K) and dexamethasone (d) (Isa-Kd) significantly improved progression-free survival (PFS) compared with Kd in patients (pts) with relapsed multiple myeloma (RMM) (HR 0.531; 99% CI, 0.318–0.889; P=0.0007), with a clinically meaningful increase in minimal residual disease negativity (MRD-) (29.6% vs 13.0%) and complete response (CR) (39.7% vs 27.6%) rates, and a manageable safety profile. This subgroup analysis of IKEMA examined efficacy and safety in pts aged <70 and ≥70 years. Methods: Pts with 1–3 prior lines of therapy were randomized 3:2 to receive Isa-Kd (n=179) or Kd (n=123). The primary end point was PFS, as assessed by an independent response committee. We compared outcomes in pts <70 vs ≥70 years; division into different or additional age groups resulted in smaller sample sizes. Results: Of the 302 randomized pts, 71.5% were aged <70 years (Isa-Kd: 70.9%; Kd: 72.4%) and 28.5% were aged ≥70 years (Isa-Kd: 29.1%; Kd: 27.6%). Consistent with the significant improvement of PFS in the overall population, the addition of Isa to Kd resulted in improved PFS independently of age (Table). The CR, ≥very good partial response (VGPR), and MRD- rates were higher with Isa-Kd vs Kd. Within the Isa-Kd arm, CR rate and ≥VGPR rate were similar in elderly and younger pts. MRD- was observed in 32.3% of younger pts and 23.1% of elderly pts with Isa-Kd. In both arms, Grade ≥3 and serious treatment-emergent adverse events (TEAEs) were more frequently reported in elderly pts vs pts <70 years old (Table). For both age groups, the incidence of Grade ≥3 TEAEs was higher whereas the incidence of serious TEAEs was similar between Isa-Kd and Kd. In the elderly subgroup, 3 (5.9%) pts receiving Isa-Kd and 1 (2.9%) receiving Kd had fatal TEAEs (Isa-Kd, infection; Kd, general health deterioration due to progressive disease). The most common Grade ≥3 TEAEs in pts aged <70 and ≥70 years treated with Isa-Kd vs Kd were hypertension (18.3% vs 17.0% [<70 years] and 25.5% vs 26.5% [≥70 years]) and pneumonia (14.3% vs 9.1% [<70 years] and 21.6% vs 20.6% [≥70 years]). Conclusions: The addition of Isa to Kd improved PFS and quality of response in elderly pts, with a manageable safety profile, consistent with the benefit observed in the overall IKEMA study population. Isa-Kd provides a potential new treatment option for elderly pts with RMM. Funding: Sanofi. Clinical trial information: NCT03275285. [Table: see text]
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Agaviezor, B. O., and C. S. Chukwuemeka. "Genetic diversity of pituitary transcription factor 1 (PIT 1) gene in Nigerian local and exotic chicken." Nigerian Journal of Animal Production 47, no. 1 (December 19, 2020): 12–18. http://dx.doi.org/10.51791/njap.v47i1.172.
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This study was carried out to investigate the genetic diversity of PIT1 gene in Nigerian local and exotic chicken breeds. Genomic DNA was extracted from the blood of Isa brown, Shika brown and Naked neck chickens which was used to amplify the PIT1 gene and later sequenced. Sequences were aligned and analyzed using Mega 6.0 and DNASp. The results revealed that Naked neck had 181 monomorphic sites and the least was observed in Isa brown (34). However, Isa brown had the highest number of polymorphic site (181) and the least was observed in Shika brown. Singleton variable sites also varied across breeds. Number of segregating sites was highest in Isa brown (174). The highest number of haplotypes was observed in Isa brown (11). Highest number of indel sites were observed in Isa brown (46) chickens. The highest estimates of average evolutionary divergence over sequence pairs within chicken breeds was observed in Isa brown (0.766) and the least in Shika brown (0.15). The highest genetic distance is between Isa brown and Naked neck and the least between Naked neck and Shika brown. The result obtained from this study revealed a clearer understanding of the genetic diversity in PIT1 gene across the different breeds. This information can be harnessed for better policies for conservation and breeding programs.
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Zimmermann, Philippe, Benoit Brethon, Julie Roupret-Serzec, Marion Caseris, Lauriane Goldwirt, André Baruchel, and Marie de Tersant. "Isavuconazole Treatment for Invasive Fungal Infections in Pediatric Patients." Pharmaceuticals 15, no. 3 (March 19, 2022): 375. http://dx.doi.org/10.3390/ph15030375.
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This work’s objective was to evaluate the safety of isavuconazole (ISA) as a treatment or prophylaxis for invasive fungal infections (IFIs) in immunocompromised children. IFI was reported as proven or probable according to international definitions. Therapeutic drug monitoring was performed using mass tandem spectrometry to quantify trough plasma concentrations. Targeted ISA levels were 2–4 mg/L, as reported in adult series. Nine patients received ISA as a curative treatment, and six received ISA as prophylaxis. IFIs were proven in four cases and probable in five. The median ISA trough plasma concentration in curative use was 3.19 mg/L [0.88;5.00], and it was 2.94 mg/L [2.77;3.29] in the prophylactic use. The median durations of treatment were 81 days [15;276] and 95 days [15;253], respectively. Three patients had elevated aspartate aminotransferase and alanine aminotransferase, and three patients had elevated creatinine serum. The IFI response was satisfactory in all cases at day 90. No side effects were reported. No patients developed an IFI. Our data underline the safety of an ISA 100 mg dosing regimen in children of <30 kg, which we recommend in this fragile population. We suggest that ISA plasma levels are monitored 10 days after ISA initiation and then every two weeks, alongside guided therapeutic drug monitoring (TDM) administration.
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Sun, Caige, Hao Chen, and Fenglei Fan. "Improving Accuracy of Impervious Surface Extraction Based on a Threshold Hierarchical Method (THM)." Applied Sciences 10, no. 23 (November 26, 2020): 8409. http://dx.doi.org/10.3390/app10238409.
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Impervious surface area (ISA) is an important representation of urban area. It is very popular to extract ISA by using linear spectral mixture analysis (LSMA). However, there are still some defects in this method: underestimated in areas with a large amount of ISA. Hence, we designed a threshold hierarchical method (THM) to test this underestimation and understand which scale is the best to mixture. The capacity of the THM and the optimal threshold in the impervious surface extraction are the focus in this work. In THM model, the medium-resolution image (Landsat 8 OLI) and the high-resolution image (Gaofen-2, GF-2) were used, the LSMA and the object-oriented method (OOM) were applied for the area with a larger amount of impervious surfaces, which was extracted from the Landsat 8 OLI image after finishing the LSMA procedure by a threshold of the ISA abundance data, the GF-2 image was employed to extract the ISA by OOM. The results show that the THM had the capacity to achieve higher ISA extraction accuracy and ameliorate the ISA underestimate problem.
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Richardson, Paul G., Aurore Perrot, Jesús F. San-Miguel, Meral Beksac, Ivan Spicka, Xavier Leleu, Fredrik Schjesvold, et al. "Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma (RRMM)." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 8017. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.8017.
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8017 Background: Isa is an approved monoclonal antibody that binds to a specific epitope on the CD38 receptor. The Phase 3 ICARIA-MM study (NCT02990338) demonstrated significantly improved progression-free survival (PFS) with Isa-Pd vs Pd ( P= 0.001) and a manageable safety profile (Attal M, et al. Lancet 2019;394:2096-2107). Here we report updated ICARIA results. Methods: Pts with RRMM (N = 307) who have received ≥2 prior therapies, including lenalidomide (Len) and a proteasome inhibitor (PI), were randomized to Isa-Pd (n = 154) or Pd (n = 153). Isa was administered intravenously at 10 mg/kg weekly for 4 weeks, and every other week thereafter. This preplanned second interim analysis assessed longer term outcomes, including time to next treatment (TTNT), overall survival (OS), time from randomization to disease progression on first subsequent therapy or death (PFS2), and safety. Results: Pts had a median of 3 prior lines of therapy (IQR 2–4; table). As of Oct 1, 2020 (median follow-up, 35.3 months [mo]), 27 Isa-Pd pts (18%) vs 12 Pd pts (8%) were still on treatment; 60% vs 72% had proceeded to subsequent therapy. Median TTNT was 15.5 mo with Isa-Pd vs 8.9 mo with Pd (hazard ratio [HR] 0.56; 95% confidence interval [CI] 0.42–0.74; P< 0.0001); 24% vs 58% of pts with subsequent therapy received daratumumab (dara). Overall response rate (ORR) in subsequent treatment with dara monotherapy was higher after Pd (38%) than Isa-Pd (14%), but was similar (32% vs 31%) with dara combination therapy (table). Median PFS2 in the intent-to-treat population was 17.5 mo with Isa-Pd vs 12.9 mo with Pd (HR 0.76; 95% CI 0.58–0.99; P= 0.0202). Median OS was 24.6 mo with Isa-Pd vs 17.7 mo with Pd (HR 0.76; 95% CI 0.58–1.01; one-sided P= 0.0280). Median treatment duration was 47.6 weeks (range 1.3–171.6) with Isa-Pd vs 24.0 weeks (range 1.0–168.6) with Pd. Serious treatment-emergent adverse event (TEAEs) were seen in 73% of Isa-Pd pts vs 60% of Pd pts. Most frequent non-hematologic TEAEs (any grade) with Isa-Pd were infusion reaction (38%), upper respiratory tract infection (34%), and diarrhea (30%). Grade 3–4 neutropenia (85% vs 71%) and thrombocytopenia (34% vs 25%) were more frequent with Isa-Pd than with Pd. Conclusions: Isa-Pd demonstrates a significant improvement in TTNT and PFS2 compared with Pd. A strong trend in OS benefit was also seen in the Isa-Pd arm, with approximately 7 mo improvement in median OS. The overall safety profile remains unchanged from prior analyses. Funding: Sanofi. Clinical trial information: NCT02990338. [Table: see text]
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Holme, Francis. "The ISA Research Program." Arboriculture & Urban Forestry 12, no. 7 (July 1, 1986): 185–88. http://dx.doi.org/10.48044/jauf.1986.040.
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Over the 12-year period 1975 through 1986, ISA has extended 116 research grants totaling $118,500, to 102 investigators at 57 institutions, and indexed as covering 294 subjects. Besides bringing about discoveries needed for practical arboriculture, the grants have generally stimulated research in this field. The annual deadline for proposals is December 1st. Proposal rules and requirements are listed.
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Jackson, J. C., G. N. Fallon, and J. R. Bishop. "DHEM at Isa Mine." Exploration Geophysics 27, no. 2-3 (June 1996): 91–104. http://dx.doi.org/10.1071/eg996091.
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Bussel, David. "ISA GENZKEN'S OUTDOOR SCULPTURE." Afterall: A Journal of Art, Context and Enquiry 2 (January 2000): 38–42. http://dx.doi.org/10.1086/aft.2.20711401.
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Cheema, Muhammad Aamir, and Mohammed Eunus Ali. "ISA 2016 workshop report." SIGSPATIAL Special 9, no. 1 (July 13, 2017): 46. http://dx.doi.org/10.1145/3124104.3124114.
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Jensen, Christian S., Ki-Joune Li, and Stephan Winter. "ISA 2010 workshop report." SIGSPATIAL Special 3, no. 1 (March 2011): 10–12. http://dx.doi.org/10.1145/1966478.1966483.
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McCready, Jim. "McCready Recognized by ISA." Forestry Chronicle 89, no. 05 (October 2013): 706. http://dx.doi.org/10.5558/tfc2013-126.
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Claramunt, Christophe, and Ki-Joune Li. "ISA 2012 workshop report." SIGSPATIAL Special 5, no. 1 (March 2013): 11–12. http://dx.doi.org/10.1145/2505403.2505408.
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Huang, Xin, Jie Yang, Wenrui Wang, and Zhengrong Liu. "Mapping 10 m global impervious surface area (GISA-10m) using multi-source geospatial data." Earth System Science Data 14, no. 8 (August 11, 2022): 3649–72. http://dx.doi.org/10.5194/essd-14-3649-2022.
Full textAbstract:
Abstract. Artificial impervious surface area (ISA) documents the human footprint. Accurate, timely, and detailed ISA datasets are therefore essential for global climate change studies and urban planning. However, due to the lack of sufficient training samples and operational mapping methods, global ISA datasets at a 10 m resolution are still lacking. To this end, we proposed a global ISA mapping method leveraging multi-source geospatial data. Based on the existing satellite-derived ISA maps and crowdsourced OpenStreetMap (OSM) data, 58 million training samples were extracted via a series of temporal, spatial, spectral, and geometric rules. We then produced a 10 m resolution global ISA dataset (GISA-10m) from over 2.7 million Sentinel optical and radar images on the Google Earth Engine platform. Based on test samples that are independent of the training set, GISA-10m achieves an overall accuracy of greater than 86 %. In addition, the GISA-10m dataset was comprehensively compared with the existing global ISA datasets, and the superiority of GISA-10m was confirmed. The global road area was further investigated, courtesy of this 10 m dataset. It was found that China and the US have the largest areas of ISA and road. The global rural ISA was found to be 2.2 times that of urban while the rural road area was found to be 1.5 times larger than that of the urban regions. The global road area accounts for 14.2 % of the global ISA, 57.9 % of which is located in the top 10 countries. Generally speaking, the produced GISA-10m dataset and the proposed sampling and mapping method are able to achieve rapid and efficient global mapping, and have the potential for detecting other land covers. It is also shown that global ISA mapping can be improved by incorporating OSM data. The GISA-10m dataset could be used as a fundamental parameter for Earth system science, and will provide valuable support for urban planning and water cycle study. The GISA-10m can be freely downloaded from https://doi.org/10.5281/zenodo.5791855 (Huang et al., 2021a).