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Relevant bibliographies by topics / Isatin mannich bases

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Academic literature on the topic 'Isatin mannich bases'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Isatin mannich bases"

1

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analg

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2

Mustafa Mahmood Mukhlif and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, and Preliminary Antimicrobial Evaluation of New Schiff Bases and Mannich Bases of Isatin." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Suppl. (2023): 156–63. http://dx.doi.org/10.31351/vol32isssuppl.pp156-163.

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Till now, isatin derivatives have received a lot of interest in organic and medicinal chemistry due to their significant biological and pharmacological activities. Schiff’s and Mannich bases of isatins are an effective group of heterocyclic derivatives that play a significant role in medicinal chemistry as antimicrobial agents. In light of these facts, new Schiff bases and Mannich bases of isatin were synthesized. The monomer Mannich bases; 3(a-e) have been synthesized by reacting isatin with different secondary amines, piperidine, morpholine, and pyrrolidine, dimethylamine, diphenylamine, sep

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3

Afsah, Elsayed M., Saad S. Elmorsy, Soha M. Abdelmageed, and Zaki E. Zaki. "Synthesis of some new mixed azines, Schiff and Mannich bases of pharmaceutical interest related to isatin." Zeitschrift für Naturforschung B 70, no. 6 (2015): 393–402. http://dx.doi.org/10.1515/znb-2014-0262.

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AbstractThe mixed azines 3a–h and 4 were obtained by treating 3-hydrazonoindolin-2-one (2) with the appropriate aldehyde or dialdehyde. Treatment of 3b or 3c with formaldehyde or glutaric dialdehyde and the appropriate amine afforded the azine Mannich bases 5–7. The condensation of isatin or its N-Mannich base 8 with 1-aminopiperidine, 4-aminomorpholine and 1,4-diaminopiperazine gave 10a–d, 12 and 13. The Mannich bases 14 and 15 were obtained from 10a and 10b. Treatment of 2 with succinic, phthalic and quinolinic anhydride and pyromellitic dianhydride afforded compounds 16, 17a, 17b and 18, re

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4

Deepthi, Kurni Lakshmi, N. J. P. Subhashini, and T. Maneshwar. "Synthesis, Molecular Docking Studies, Antimicrobial, Anticancer and Antioxidant Activity of Some Novel Mannich Bases of Isatin Scaffold." Asian Journal of Chemistry 34, no. 5 (2022): 1097–104. http://dx.doi.org/10.14233/ajchem.2022.23561.

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A series of novel Mannich bases of isatin derivatives (VIIIa-VIIIt) was synthesized and evaluated as potential antimicrobial, antioxidant, anticancer activities and molecular docking studies. Structure of all the isatin derivatives was evaluated by IR, 1H NMR and mass spectral analysis. The antimicrobial activity results indicated that compounds VIIIb, VIIIi, VIIIm and VIIIo showed good activity in comparison to the activities of the standard molecules. Further, all isatin derivatives (VIIIa-VIIIt) have studied for their antioxidant activity by using ferric reducing antioxidant power assay (FR

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5

V., J. Patro, S. Panda C., M. Sahoo B., K. Mishra N., and R. Panda J. "Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione." Journal of Indian Chemical Society Vol. 89, Jul 2012 (2012): 913–18. https://doi.org/10.5281/zenodo.5766824.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Orissa, India <em>E-mail</em> : jrpanda77@gmail.com Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa, India <em>Manuscript received 04 February 2011, revised 16 June 2011, accepted 08 November 2011</em> The reaction of isatin (1<em>H</em>-indole-2,3-dione) with substituted anilines in presence of acetic acid produces Schiff bases. Reaction of the Schiff bases with different secondary amines in presence of formaldehyde yields Mann

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6

Hajare, Rahul. "Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery." International Physiology Journal, no. 2 (May 3, 2018): 7–14. http://dx.doi.org/10.14302/issn.2578-8590.ipj-18-2113.

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Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reaction at C-3 and N-1 position and synthesized lead in present schme and seen the similarity of structure and analgesic-anti-inflammatory activity.

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7

Mohammed Sameer Abdul Shahed and Ahmed H. Mageed. "One-pot Multicomponent Synthesis and Biological Activity of Oxindole- linked Isatin Schiff Bases Derivatives." Journal of Kufa for Chemical Sciences 3, no. 2 (2024): 31–53. http://dx.doi.org/10.36329/jkcm/2024/v3.i2.12321.

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The study focuses on the synthesis of isatin- oxindole compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either oxindole, along with formaldehyde. This reaction results in the formation of Isatin- oxindole derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. The synthesized compounds are characterized using spectroscopic techniques such as FTIR, 1H NMR, and 13C NMR. The study also explores the biol

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8

Almusawi, Marwa hashim, and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, Molecular Docking, and Antimicrobial Evaluation of New Acetylenic Mannich Bases of Isatin–Thiazole Derivatives." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 77–88. https://doi.org/10.31351/vol33iss(4si)pp77-88.

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The isatin molecule is present in many natural substances, like plants and animals, and it is utilized to prepare compounds with various biological activities. A series of Schiff and Mannich bases derived from isatin were synthesized in this research. First, acetylenic Mannich bases (IIa-e) were prepared by a reaction of isatin with propargyl bromide and different secondary amines (morpholine, piperidine, pyrrolidine, dimethylamine, and diphenylamine) separately, and cuprous chloride (CuCl) was used as a catalyst. Second, these Mannich bases were treated with 2-aminothiazole to obtain the desi

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9

Al-Musawi, Marwa Hashim, and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, Molecular Docking, ADMET Study, and Antimicrobial Evaluation of New Mannich Bases of Isatin–Thiazole Imine Bases." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 6, no. 2 (2024): 201–8. http://dx.doi.org/10.54133/ajms.v6i2.835.

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Background: The isatin molecule is present in many natural substances, including plants and animals, and is used to prepare compounds with various biological activities. Objectives: To synthesize a new series of isatin derivatives with the expectation that they will have antimicrobial activity. Methods: Thiazole Schiff bases were synthesized from various Mannich bases of isatin to evaluate their antimicrobial properties. Initially, Mannich bases (2a–e) were synthesized by reacting isatin with formaldehyde and different secondary amines. Subsequently, they were treated with 2-aminothiazole to y

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10

Zhu, Jing-Yan, Wu-Lin Yang, Yang-Zi Liu, Shao-Jing Shang, and Wei-Ping Deng. "A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles." Organic Chemistry Frontiers 5, no. 1 (2018): 70–74. http://dx.doi.org/10.1039/c7qo00691h.

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