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Journal articles on the topic 'Isatin mannich bases'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analg

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2

Mustafa Mahmood Mukhlif and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, and Preliminary Antimicrobial Evaluation of New Schiff Bases and Mannich Bases of Isatin." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Suppl. (2023): 156–63. http://dx.doi.org/10.31351/vol32isssuppl.pp156-163.

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Till now, isatin derivatives have received a lot of interest in organic and medicinal chemistry due to their significant biological and pharmacological activities. Schiff’s and Mannich bases of isatins are an effective group of heterocyclic derivatives that play a significant role in medicinal chemistry as antimicrobial agents. In light of these facts, new Schiff bases and Mannich bases of isatin were synthesized. The monomer Mannich bases; 3(a-e) have been synthesized by reacting isatin with different secondary amines, piperidine, morpholine, and pyrrolidine, dimethylamine, diphenylamine, sep

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3

Afsah, Elsayed M., Saad S. Elmorsy, Soha M. Abdelmageed, and Zaki E. Zaki. "Synthesis of some new mixed azines, Schiff and Mannich bases of pharmaceutical interest related to isatin." Zeitschrift für Naturforschung B 70, no. 6 (2015): 393–402. http://dx.doi.org/10.1515/znb-2014-0262.

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AbstractThe mixed azines 3a–h and 4 were obtained by treating 3-hydrazonoindolin-2-one (2) with the appropriate aldehyde or dialdehyde. Treatment of 3b or 3c with formaldehyde or glutaric dialdehyde and the appropriate amine afforded the azine Mannich bases 5–7. The condensation of isatin or its N-Mannich base 8 with 1-aminopiperidine, 4-aminomorpholine and 1,4-diaminopiperazine gave 10a–d, 12 and 13. The Mannich bases 14 and 15 were obtained from 10a and 10b. Treatment of 2 with succinic, phthalic and quinolinic anhydride and pyromellitic dianhydride afforded compounds 16, 17a, 17b and 18, re

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4

Deepthi, Kurni Lakshmi, N. J. P. Subhashini, and T. Maneshwar. "Synthesis, Molecular Docking Studies, Antimicrobial, Anticancer and Antioxidant Activity of Some Novel Mannich Bases of Isatin Scaffold." Asian Journal of Chemistry 34, no. 5 (2022): 1097–104. http://dx.doi.org/10.14233/ajchem.2022.23561.

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A series of novel Mannich bases of isatin derivatives (VIIIa-VIIIt) was synthesized and evaluated as potential antimicrobial, antioxidant, anticancer activities and molecular docking studies. Structure of all the isatin derivatives was evaluated by IR, 1H NMR and mass spectral analysis. The antimicrobial activity results indicated that compounds VIIIb, VIIIi, VIIIm and VIIIo showed good activity in comparison to the activities of the standard molecules. Further, all isatin derivatives (VIIIa-VIIIt) have studied for their antioxidant activity by using ferric reducing antioxidant power assay (FR

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5

V., J. Patro, S. Panda C., M. Sahoo B., K. Mishra N., and R. Panda J. "Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione." Journal of Indian Chemical Society Vol. 89, Jul 2012 (2012): 913–18. https://doi.org/10.5281/zenodo.5766824.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Orissa, India <em>E-mail</em> : jrpanda77@gmail.com Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa, India <em>Manuscript received 04 February 2011, revised 16 June 2011, accepted 08 November 2011</em> The reaction of isatin (1<em>H</em>-indole-2,3-dione) with substituted anilines in presence of acetic acid produces Schiff bases. Reaction of the Schiff bases with different secondary amines in presence of formaldehyde yields Mann

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6

Hajare, Rahul. "Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery." International Physiology Journal, no. 2 (May 3, 2018): 7–14. http://dx.doi.org/10.14302/issn.2578-8590.ipj-18-2113.

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Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reaction at C-3 and N-1 position and synthesized lead in present schme and seen the similarity of structure and analgesic-anti-inflammatory activity.

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7

Mohammed Sameer Abdul Shahed and Ahmed H. Mageed. "One-pot Multicomponent Synthesis and Biological Activity of Oxindole- linked Isatin Schiff Bases Derivatives." Journal of Kufa for Chemical Sciences 3, no. 2 (2024): 31–53. http://dx.doi.org/10.36329/jkcm/2024/v3.i2.12321.

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The study focuses on the synthesis of isatin- oxindole compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either oxindole, along with formaldehyde. This reaction results in the formation of Isatin- oxindole derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. The synthesized compounds are characterized using spectroscopic techniques such as FTIR, 1H NMR, and 13C NMR. The study also explores the biol

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8

Almusawi, Marwa hashim, and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, Molecular Docking, and Antimicrobial Evaluation of New Acetylenic Mannich Bases of Isatin–Thiazole Derivatives." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 77–88. https://doi.org/10.31351/vol33iss(4si)pp77-88.

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The isatin molecule is present in many natural substances, like plants and animals, and it is utilized to prepare compounds with various biological activities. A series of Schiff and Mannich bases derived from isatin were synthesized in this research. First, acetylenic Mannich bases (IIa-e) were prepared by a reaction of isatin with propargyl bromide and different secondary amines (morpholine, piperidine, pyrrolidine, dimethylamine, and diphenylamine) separately, and cuprous chloride (CuCl) was used as a catalyst. Second, these Mannich bases were treated with 2-aminothiazole to obtain the desi

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9

Al-Musawi, Marwa Hashim, and May Mohammed Jawad Al-Mudhafar. "Synthesis, Characterization, Molecular Docking, ADMET Study, and Antimicrobial Evaluation of New Mannich Bases of Isatin–Thiazole Imine Bases." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 6, no. 2 (2024): 201–8. http://dx.doi.org/10.54133/ajms.v6i2.835.

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Background: The isatin molecule is present in many natural substances, including plants and animals, and is used to prepare compounds with various biological activities. Objectives: To synthesize a new series of isatin derivatives with the expectation that they will have antimicrobial activity. Methods: Thiazole Schiff bases were synthesized from various Mannich bases of isatin to evaluate their antimicrobial properties. Initially, Mannich bases (2a–e) were synthesized by reacting isatin with formaldehyde and different secondary amines. Subsequently, they were treated with 2-aminothiazole to y

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10

Zhu, Jing-Yan, Wu-Lin Yang, Yang-Zi Liu, Shao-Jing Shang, and Wei-Ping Deng. "A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles." Organic Chemistry Frontiers 5, no. 1 (2018): 70–74. http://dx.doi.org/10.1039/c7qo00691h.

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11

Jithendra, Ch, G. Saravanan, V. Alagarsamy, T. Panneerselvam, K. Selvaraj, and P. Parasuraman. "Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs." Asian Journal of Chemistry 32, no. 4 (2020): 970–74. http://dx.doi.org/10.14233/ajchem.2020.22596.

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A sequence of new isoxazole substituted Schiff base and Mannich base of 5-nitroisatin are synthesized by a multi-step synthesis from 5-nitroisatin. Whole synthesized analogs were characterized using IR, NMR, Mass spectroscopy and microanalyses. All the Schiff and Mannich bases were tested for their antimicrobial potencies against some human pathogenic microorganism using agar well diffusion technique. The relationship between the biological activity and the functional group variation of the Schiff and Mannich bases were analyzed. Standard ciprofloxacin and ketoconazole were used to compare the

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12

Isgor, Kucukgul, Karaman, et al. "IN VITRO AND IN SILICO CYTOTOXICITY EVALUATION OF SOME ISATIN MANNICH BASES ON HUMAN MELANOMA CELLS." Apoptosis, cytotoxicity, isatin mannich bases, melanoma, molecular docking 16, no. 1 (2022): 102–14. https://doi.org/10.5281/zenodo.5826186.

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Mannich bases tend to suppress cell proliferation in damaged tissues because of particular metal chelation properties. Amine components of isatin mannich bases - piperidine (P1), morpholine (P2) and N-methyl piperazine (P3) – were evaluated for their cytotoxicity potentials on melanoma cells. P1, P2 and P3 products were purified using crystallization and characterized by NMR. Human melanoma cells (G361) were produced in DMEM medium including 10% FBS, 1% penicillin/streptomycin at 37°C and 5% CO<sub>2</sub> conditions. Compounds were applied to medium containers separated to 24 pieces

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13

Pandeya, S. N., D. Sriram, P. Yogeeswari, and S. Ananthan. "Antituberculous Activity of Norfloxacin Mannich Bases with Isatin Derivatives." Chemotherapy 47, no. 4 (2001): 266–69. http://dx.doi.org/10.1159/000048533.

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14

Sriram, Dharmarajan, Tanushree Ratan Bal, and Perumal Yogeeswari. "Synthesis, Antiviral and Antibacterial Activities of Isatin Mannich Bases." Medicinal Chemistry Research 14, no. 4 (2005): 211–28. http://dx.doi.org/10.1007/s00044-005-0135-x.

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15

Isgor, Mehmet Mustafa, Altug Kucukgul, Muhammet Karaman, et al. "IN VITRO AND IN SILICO CYTOTOXICITY EVALUATION OF SOME ISATIN MANNICH BASES ON HUMAN MELANOMA CELLS." Journal of Applied Biological Sciences 16, no. 1 (2022): 102–14. https://doi.org/10.71336/jabs.968.

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Mannich bases tend to suppress cell proliferation in damaged tissues because of particular metal chelation properties. Amine components of isatin mannich bases - piperidine (P1), morpholine (P2) and N-methyl piperazine (P3) – were evaluated for their cytotoxicity potentials on melanoma cells. P1, P2 and P3 products were purified using crystallization and characterized by NMR. Human melanoma cells (G361) were produced in DMEM medium including 10% FBS, 1% penicillin/streptomycin at 37°C and 5% CO2 conditions. Compounds were applied to medium containers separated to 24 pieces plates as 1x105 mela

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16

Ilango, K., P. Valentina, B. Sudhakar, and K. Subhakar. "Synthesis and Antimicrobial Screening of some Mannich Bases of Isatin." Journal of Pharmaceutical Research 8, no. 2 (2009): 93. http://dx.doi.org/10.18579/jpcrkc/2009/8/2/79772.

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17

Orlova, D. D., D. S. Novikova, A. V. Garabadzhiu, and V. G. Tribulovich. "A Study on Hydrolytic Stability of Isatin N-Mannich Bases." Russian Journal of General Chemistry 88, no. 1 (2018): 48–56. http://dx.doi.org/10.1134/s1070363218010085.

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18

Afsah, Elsayed M., Saad S. Elmorsy, Soha M. Abdelmageed, and Zaki E. Zaki. "Synthesis of some new hydrazide-hydrazones related to isatin and its Mannich and Schiff bases." Zeitschrift für Naturforschung B 71, no. 11 (2016): 1147–57. http://dx.doi.org/10.1515/znb-2016-0130.

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AbstractThe hydrazide-hydrazones 6a–d and 7a, b were obtained by treating isatin (1) or its Mannich base 2 with hydrazides incorporating piperidine, morpholine, and piperazine units. The reaction of 1 and 2 with hydrazides related to triazenes having piperidine, morpholine, and 1,2,3,4-tetrahydroisoquinoline moieties gave 12a–c and 13a–c. Treatment of 1 and 2 with iminodiacetohydrazide (14) and ethylenediamine tetraacetohydrazide (18) afforded 15–17 and 19a, b, respectively. The Mannich reaction of the Schiff base 20 with formaldehyde and the appropriate hydrazide or bis(hydrazide) gave 21a, b

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19

Sammaiah G., Venkatesh E., Sunitha T., and Sri Ramya T. "Evaluation of Antimicrobial and Antioxidant Activity of Newly Synthesized NMannich Bases from Methyl Salicylate." International Journal of Zoological Investigations 08, Special Issue (2022): 75–84. http://dx.doi.org/10.33745/ijzi.2022.v08i0s.009.

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Isatin reacted with formaldehyde and a number of secondary amines in order to produce the N-Mannich bases of isatin derivatives. FT-IR, 1H-NMR, and mass spectrum data were used to demonstrate that their chemical structures were accurate. An agar diffusion method was used to examine the antibacterial activity of compounds against Gram (+) bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram (-) bacteria (Escherichia coli and Klebsiella pneumonia), with streptomycin employed as control. The antifungal activity of fluconazole against Candida albicans and Aspergillus niger was measured

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20

Sridhar, Seshaiah Krishnan, Surendra N. Pandeya, James P. Stables, and Atmakuru Ramesh. "Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives." European Journal of Pharmaceutical Sciences 16, no. 3 (2002): 129–32. http://dx.doi.org/10.1016/s0928-0987(02)00077-5.

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21

NIKOLAEV, A. YU, O. M. LAVROVA, R. G. TAGASHEVA, D. K. KOMUNAROVA, E. L. GAVRILOVA, and A. V. BOGDANOV. "SYNTHESIS OF HYBRID COMPOUNDS BASED ON ISATIN DERIVATIVES AND PHOSPHORYLCARBOXYLIC ACID HYDRAZIDES." Herald of Technological University 27, no. 8 (2024): 29–33. https://doi.org/10.55421/1998-7072_2024_27_8_29.

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The development of new biologically active substances and pharmaceuticals often involves the strategic combination of different pharmacophore elements into hybrid structures. Drugs created using this method may have increased efficacy, reduced toxicity and a multifaceted spectrum of biological action. Isatin is isolated as a synthetically versatile substance, often used in the creation of various heterocyclic structures. There are two active sites in its structure - a carbonyl group and a lactam segment, which makes isatin an excellent basis for the development of hybrid biologically active co

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22

Nisheeth, Rastogi, Anil Harrison Darwin, Tripathi Diwakar, and Shukla Sarveshwar. "Synthesis and antimicrobial potential of Mannich bases of 4-chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones." Journal of Indian Chemical Society Vol. 86, Sep 2009 (2009): 991–95. https://doi.org/10.5281/zenodo.5820060.

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Department of Chemistry, Lucknow Christian Post-Graduate College, Lucknow-226 018, Uttar Pradesh, India <em>E-mail </em>: nisheethrastogi2003@yahoo.co.in Department of Chemistry, Sri Jai Narain Post-Graduate College, Lucknow-226 001, Uttar Pradesh, India <em>Manuscript received 3 March 2009, accepted 26 May 2009</em> 4-Chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones (1-4) were synthesised by the condensation of 4-(chlorobenzyloxy)-benzoylhydrazines and 4-chloroisatin. On being subjected to aminomethylation in the presence of formaldehyde and heterocyclic secondary amines, indol

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23

Afsah, Elsayed M., Ahmad A. Fadda, and Ahlam H. Hanash. "Synthesis of a New Series ofN-Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases." Journal of Heterocyclic Chemistry 55, no. 3 (2018): 736–42. http://dx.doi.org/10.1002/jhet.3097.

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24

Panda, Jnyanaranjan, Biswa Mohan Sahoo, Nikunja Kishor Mishra, Sai Krushna Padhi, and Jitendriya Mishra. "Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives." Journal of Nanomaterials 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/272598.

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A simple and efficient method has been developed for the synthesis of 1,3-dihydro-2H-indol-2-one derivatives using microwave irradiation technique. By taking advantage of the efficient source of energy of microwave, compound libraries for lead generation and optimization can be assembled in a fraction of time. In the present work, first the Schiff’s bases are synthesized by reaction of isatin with substituted anilines in the presence of acetic acid under microwave heating. Then the condensation of Schiff bases with different secondary amines in the presence of formaldehyde produces Mannich bas

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25

Ozgun, Dilan Ozmen, Cem Yamali, Halise Inci Gul, et al. "Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. 6 (2016): 1498–501. http://dx.doi.org/10.3109/14756366.2016.1149479.

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26

Venkateshan, N., R. Rajapandi, and P. Kaniga. "SYNTHESIS, ANTIBACTERIAL EVALUATION AND DOCKING STUDIES OF SOME NOVEL ISATIN DERIVATIVES." INDIAN DRUGS 55, no. 03 (2018): 7–12. http://dx.doi.org/10.53879/id.55.03.11284.

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Benzylimino isatin Mannich bases (IS1 & IM1-IM6) were designed manually and synthesized by the simple Mannich reaction. The synthesized compounds were confirmed by means of their spectral evidence (FTIR, 1H NMR and ESI-MS). The antibacterial activities were carried out with Gram +ve as well as Gram -ve bacteria by disc diffusion method. All the compounds showed moderate In vitro antibacterial activity, particularly, compound IM4 (E)-3-(benzylimino)-1-[(4-methylpiperazin-1-yl)methyl]indolin-2 -one showed better activity with 19, 17, 17 and 11 mm zone of inhibition at 100 μg/0.1 mL concentra

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27

SRIDHAR, Seshaiah Krishnan, and Atmakuru RAMESH. "Synthesis and Pharmacological Activities of Hydrazones, Schiff and Mannich Bases of Isatin Derivatives." Biological & Pharmaceutical Bulletin 24, no. 10 (2001): 1149–52. http://dx.doi.org/10.1248/bpb.24.1149.

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28

Sridhar, Seshaiah Krishnan, Muniyandy Saravanan, and Atmakuru Ramesh. "Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives." European Journal of Medicinal Chemistry 36, no. 7-8 (2001): 615–25. http://dx.doi.org/10.1016/s0223-5234(01)01255-7.

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29

Mondal, P., S. Jana, A. Bose, and M. Banerjee. "Synthesis and Evaluation of 1,3 Di-Substituted Schiff, Mannich Bases and Spiro Isatin Derivatives." Journal of Young Pharmacists 2, no. 2 (2010): 169–72. http://dx.doi.org/10.4103/0975-1483.63164.

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30

Hussein, Mostafa, Tarek Aboul-Fadl, and Asmma Hussein. "SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME MANNICH BASES DERIVED FROM ISATIN ISONICOTINIC ACID HYDRAZONE." Bulletin of Pharmaceutical Sciences. Assiut 28, no. 1 (2005): 131–36. http://dx.doi.org/10.21608/bfsa.2005.65240.

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31

Kumar, NSaravana, T. Pradeep, G. Jani, Divya Silpa, and BVijaya Kumar. "Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases." Journal of Advanced Pharmaceutical Technology & Research 3, no. 1 (2012): 57. http://dx.doi.org/10.4103/2231-4040.93559.

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32

Chen, Gang, Yang Ning, Wei Zhao, et al. "Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases." Letters in Drug Design & Discovery 13, no. 5 (2016): 395–400. http://dx.doi.org/10.2174/1570180812666150907203342.

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33

Shrivastava, Shobhit, and Dharmendra Ahuja. "Synthesis, Characterization and Antimicrobial Activity of Some Novel Mannich Bases of Indole-2,3-dione." Asian Journal of Chemistry 35, no. 5 (2023): 1183–88. http://dx.doi.org/10.14233/ajchem.2023.27738.

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Indole-2,3-dione (isatin) and its 5-substituted derivatives have been reacted with N2-benzylidenepyridine-2,6-diamine to form Schiff bases and the Mannich bases of these compounds were synthesized by reacting them with some secondary amines in presence of formaldehyde. Their chemical structures have been confirmed by mean of their IR and 1H NMR. Antimicrobial screening of synthesized compounds was done by well diffusion method against 4 pathogenic bacteria and 2 pathogenic fungi. Amongst the tested compounds 3-{[6-(benzylideneamino)pyridin-2-yl]imino}-1- (piperazin-1-ylmethyl)-5-fluoro-indolin

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34

Jnyanaranjan, Panda, Kumar Anjan, Mohan Sahoo Biswa, and Krishna Banik Bimal. "Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1283–88. https://doi.org/10.5281/zenodo.5652463.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India Department of Pharmacy, Vikas Group of Institution, Vijayawada-521 212, Andhra Pradesh, India Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: jrpanda77@gmail.com, drbiswamohansahoo@gmail.com <em>Manuscript received 28 September 2018, accepted 01 November 2018</em> An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considerin

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35

Pandeya, S. N., P. Yogeeswari, D. Sriram, E. de Clercq, C. Pannecouque, and M. Witvrouw. "Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives." Chemotherapy 45, no. 3 (1999): 192–96. http://dx.doi.org/10.1159/000007182.

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36

Bogdanov, Andrei V., Vladimir F. Mironov, Lenar I. Musin, Rashid Z. Musin, Dmitry B. Krivolapov, and Igor A. Litvinov. "A convenient synthetic route from isatin N-Mannich bases to nitrogen-containing derivatives of isoindigo." Monatshefte für Chemie - Chemical Monthly 142, no. 1 (2010): 81–85. http://dx.doi.org/10.1007/s00706-010-0416-z.

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37

Al-Syari, Abdulkarim H., and Saieba S. Hassan. "Synthesis and Spectroscopic Study of Some New 1,2,4-Triazino[5,6-b]indole Derivatives." Thamar University Journal of Natural & Applied Sciences 2, no. 2 (2023): 57–68. http://dx.doi.org/10.59167/tujnas.v2i2.1274.

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The Scheme of this work included the synthesis and characterization of new two series of 1,2,4-triazino[5,6-b] indole and 8-bromo-1,2,4-triazino[5,6-b] indole derivatives according to the starting material used. Both, derivatives of 3-thione-1,2,4-triazino[5,6-b] indole and 8-bromo-3-thione-1,2,4-triazino[5,6-b] indole (3a & 3b) were prepared by using Isatin and 5-bromo isatin as a starting material, the new schiff`s bases (5a & 5b) were synthesized by the reaction of hydrazino indole derivatives (4a & 4b) with aromatic aldehydes. Tetracyclic derivatives (7a & 7b) were prepared

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38

Gupta, R. P., B. N. Yadav, and Ashutosh K. Srivastava. "Synthesis of some Mannich bases of isatin-3-(4′-phenyl-3′-thiosemicarbazone) and their antibacterial activity." Proceedings / Indian Academy of Sciences 94, no. 3 (1985): 475–80. http://dx.doi.org/10.1007/bf02867443.

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39

Pandeya, S. N., D. Sriram, G. Nath, and E. De Clercq. "Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine." Il Farmaco 54, no. 9 (1999): 624–28. http://dx.doi.org/10.1016/s0014-827x(99)00075-0.

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40

Bogdanov, Andrei V., Al’bina M. Vazykhova, Nadezhda R. Khasiyatullina, et al. "New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity." Chemistry of Heterocyclic Compounds 52, no. 1 (2016): 25–30. http://dx.doi.org/10.1007/s10593-016-1826-6.

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41

Bogdanov, Andrei V., Vladimir F. Mironov, Lenar I. Musin, Rashid Z. Musin, Dmitry B. Krivolapov, and Igor A. Litvinov. "ChemInform Abstract: A Convenient Synthetic Route from Isatin N-Mannich Bases to Nitrogen-Containing Derivatives of Isoindigo." ChemInform 42, no. 17 (2011): no. http://dx.doi.org/10.1002/chin.201117182.

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Singh, Ashish Kumar, and M. A. Quraishi. "Inhibiting effects of 5-substituted isatin-based Mannich bases on the corrosion of mild steel in hydrochloric acid solution." Journal of Applied Electrochemistry 40, no. 7 (2010): 1293–306. http://dx.doi.org/10.1007/s10800-010-0079-9.

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43

Abdulghani, Ahlam J., and Nada M. Abbas. "Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide." Bioinorganic Chemistry and Applications 2011 (2011): 1–15. http://dx.doi.org/10.1155/2011/706262.

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Abstract:

Two new Schiff and Mannich bases, namely, 1-Morpholinomethyl-3(1′ -N-dithiooxamide)iminoisatin (LIH) and 1-diphenylaminomethyl-3-1′-N-dithiooxamide)iminoisatin (LIIH), were prepared from condensation reaction of new Schiff base 3-(1′-N-dithiooxamide)iminoisatin (SBH) with morpholine or diphenylamine respectively in presence of formaldehyde . The structures were characterized by IR,1HNMR, mass spectrometry, and CHN analyses. Metal complexes of the two ligands were synthesized, and their structures were characterized by elemental analyses, atomic absorption, IR and UV-visible spectra, molar cond

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Bekircan, Olcay, and Hakan Bektas. "Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones." Molecules 13, no. 9 (2008): 2126–35. http://dx.doi.org/10.3390/molecules13092126.

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Ravichandran, V., S. Mohan, and K. Suresh Kumar. "Synthesis and antimicrobial activity of Mannich bases of isatin and its derivatives with 2-[(2,6-dichlorophenyl)amino]phenylacetic acid." Arkivoc 2007, no. 14 (2007): 51–57. http://dx.doi.org/10.3998/ark.5550190.0008.e07.

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Pandeya, Surendra, Dharmarajan Sriram, Gopal Nath, and Erik Clercq. "Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and its Derivatives with Triazole." Arzneimittelforschung 50, no. 01 (2011): 55–59. http://dx.doi.org/10.1055/s-0031-1300164.

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Ahamad, Ishtiaque, Rajendra Prasad, and M. A. Quraishi. "Adsorption and inhibitive properties of some new Mannich bases of Isatin derivatives on corrosion of mild steel in acidic media." Corrosion Science 52, no. 4 (2010): 1472–81. http://dx.doi.org/10.1016/j.corsci.2010.01.015.

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Bhushan D. Varpe and Shailaja B. Jadhav. "Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity." Russian Journal of Bioorganic Chemistry 48, no. 2 (2022): 372–79. http://dx.doi.org/10.1134/s1068162022020030.

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Pandeya, Surendra N., Dharmarajan Sriram, Gopal Nath, and Erik de Clercq. "ChemInform Abstract: Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and Its Derivatives with Triazole." ChemInform 31, no. 15 (2010): no. http://dx.doi.org/10.1002/chin.200015118.

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Murthy, Yellajyosula Lakshmi Narasimha, Boddeti Govindh, Bhagavathula S. Diwakar, Karthikeyan Nagalakshmi, and Kothagorla Venkata Raghava Rao. "Synthesis and bioevaluation of Schiff and Mannich bases of isatin derivatives with 4-amino-5-benzyl-2,4-dihydro-3H-1,2,4-triazole-3-thione." Medicinal Chemistry Research 21, no. 10 (2011): 3104–10. http://dx.doi.org/10.1007/s00044-011-9838-3.

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