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Journal articles on the topic 'Ischaemic stroke research'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Chauhan, Anjali, Hope Moser, and Louise D. McCullough. "Sex differences in ischaemic stroke: potential cellular mechanisms." Clinical Science 131, no. 7 (2017): 533–52. http://dx.doi.org/10.1042/cs20160841.

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Stroke remains a leading cause of mortality and disability worldwide. More women than men have strokes each year, in part because women live longer. Women have poorer functional outcomes, are more likely to need nursing home care and have higher rates of recurrent stroke compared with men. Despite continued advancements in primary prevention, innovative acute therapies and ongoing developments in neurorehabilitation, stroke incidence and mortality continue to increase due to the aging of the U.S. population. Sex chromosomes (XX compared with XY), sex hormones (oestrogen and androgen), epigenet

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Lake, Evelyn M. R., Paolo Bazzigaluppi, and Bojana Stefanovic. "Functional magnetic resonance imaging in chronic ischaemic stroke." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1705 (2016): 20150353. http://dx.doi.org/10.1098/rstb.2015.0353.

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Ischaemic stroke is the leading cause of adult disability worldwide. Effective rehabilitation is hindered by uncertainty surrounding the underlying mechanisms that govern long-term ischaemic injury progression. Despite its potential as a sensitive non-invasive in vivo marker of brain function that may aid in the development of new treatments, blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has found limited application in the clinical research on chronic stage stroke progression. Stroke affects each of the physiological parameters underlying the BOLD contr

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Moxon, Joseph V., Alexandra F. Trollope, Brittany Dewdney, et al. "The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis." Journal of Cerebral Blood Flow & Metabolism 39, no. 12 (2019): 2343–54. http://dx.doi.org/10.1177/0271678x19876876.

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Clinical studies report that low circulating angiopoietin-1 concentration at presentation predicts worse outcomes after ischaemic stroke. Upregulating angiopoietin-1 may therefore have therapeutic benefit for ischaemic stroke. This systematic review assessed whether upregulating angiopoietin-1 improved outcomes in rodent models of ischaemic stroke. Random-effects models quantified the effect of angiopoietin-1 upregulation on stroke severity in terms of the size of cerebral infarction and the extent of blood–brain barrier permeability. Eleven studies utilising rat and mouse models of ischaemic

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Liu, Yan, Bo Yin, and Yanping Cong. "The Probability of Ischaemic Stroke Prediction with a Multi-Neural-Network Model." Sensors 20, no. 17 (2020): 4995. http://dx.doi.org/10.3390/s20174995.

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As is known, cerebral stroke has become one of the main diseases endangering people’s health; ischaemic strokes accounts for approximately 85% of cerebral strokes. According to research, early prediction and prevention can effectively reduce the incidence rate of the disease. However, it is difficult to predict the ischaemic stroke because the data related to the disease are multi-modal. To achieve high accuracy of prediction and combine the stroke risk predictors obtained by previous researchers, a method for predicting the probability of stroke occurrence based on a multi-model fusion convol

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Fraser, Justin F. "Standardisation of research strategies in acute ischaemic stroke." Lancet Neurology 15, no. 8 (2016): 784–85. http://dx.doi.org/10.1016/s1474-4422(16)30080-1.

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Appleton, Jason P., Randeep Mullhi, and Naginder Singh. "Initial management of acute ischaemic stroke." British Journal of Hospital Medicine 82, no. 1 (2021): 1–9. http://dx.doi.org/10.12968/hmed.2020.0193.

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The management of acute ischaemic stroke has been revolutionised by effective reperfusion therapies including thrombolysis and mechanical thrombectomy. In particular, mechanical thrombectomy has heralded a new era in stroke medicine. There have also been developments to improve clinical outcomes for patients who have had an acute ischaemic stroke but are not eligible for this procedure. This article presents an update on the initial management of acute ischaemic stroke, including reperfusion therapies, periprocedural considerations and ongoing research for potential improvements in the care of

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Jia, Jia, Jie Li, and Jian Cheng. "H2S-based therapies for ischaemic stroke: opportunities and challenges." Stroke and Vascular Neurology 4, no. 2 (2019): 63–66. http://dx.doi.org/10.1136/svn-2018-000194.

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Stroke is a cerebrovascular disease displaying high mortality and morbidity. Despite extensive efforts, only very few therapies are available for stroke patients as yet. Hydrogen sulfide (H2S) is thought to be a signalling molecule that is endogenously produced and plays functional roles in the central nervous system. Currently, numerous studies show that H2S impacts stroke outcomes in animal and cellular models. Here, we review the recent research regarding the effects of endogenously produced H2S as well as exogenous H2S donors on stroke pathology, focusing on the potential of H2S-based ther

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Kirkham, Fenella, Guillaume Sébire, Maja Steinlin, and Ronald Sträter. "Arterial ischaemic stroke in children." Thrombosis and Haemostasis 92, no. 10 (2004): 697–706. http://dx.doi.org/10.1160/th04-04-0209.

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SummaryConditions associated with arterial ischaemic stroke in children include a great variety of diseases and triggers such as congenital heart malformations, sickle cell disease, infections and vasculopathies, although up to 50% are cryptogenic. An abnormal vascular status can be demonstrated by vascular imaging in up to 80% of children with ischaemic stroke, and case control studies demonstrate an association between ischaemic stroke in children and hereditary prothrombotic risk factors and infections such as Varicella. Conventional risk factors such as hypertension and dyslipidaemia may a

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Kermode-Scott, Barbara. "Research suggests thrombolysis is effective for acute ischaemic stroke." BMJ 330, no. 7501 (2005): 1167.2. http://dx.doi.org/10.1136/bmj.330.7501.1167-a.

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Kang, Eugene Yu-Chuan, Yun-Hsuan Lin, Nan-Kai Wang, et al. "Aspirin use in central retinal arterial occlusion to prevent ischaemic stroke: a retrospective cohort study in Taiwan." BMJ Open 9, no. 2 (2019): e025455. http://dx.doi.org/10.1136/bmjopen-2018-025455.

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ObjectiveTo understand the efficacy of aspirin use for preventing ischaemic stroke after central retinal artery occlusion (CRAO).DesignThe retrospective cohort study was conducted using the National Health Insurance Research Database from 1998 to 2013.SettingA population-based study.ParticipantsA total of 9437 participants with newly diagnosed CRAO were identified. Participants who had a previous stroke and/or retinal vascular occlusion, were aged <20 years and used aspirin 3 months before the event were excluded. There were 3778 eligible participants matched by propensity score, and they w

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Damiza-Detmer, Agnieszka, Izabela Damiza, and Małgorzata Pawełczyk. "Wake-up stroke – diagnosis, management and treatment." Aktualności Neurologiczne 20, no. 2 (2020): 66–70. http://dx.doi.org/10.15557/an.2020.0009.

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Wake-up stroke is defined as ischaemic stroke with unknown time of symptom onset, when patients go to sleep normal and awaken with neurological symptoms. This type of stoke accounts for about 20% (14–24%) of all ischaemic strokes. The high incidence of wake-up stroke may be associated with diurnal variability of heart rate and blood pressure, coagulation processes, as well as episodes of atrial fibrillation, which are more common in the morning. The risk of wake-up stroke increases during REM sleep. Individuals with obstructive sleep apnoea account for the majority of patients with wake-up str

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Camen, Stephan, Francisco M. Ojeda, Teemu Niiranen, et al. "Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality." EP Europace 22, no. 4 (2019): 522–29. http://dx.doi.org/10.1093/europace/euz312.

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Abstract Aims Limited evidence is available on the temporal relationship between atrial fibrillation (AF) and ischaemic stroke and their impact on mortality in the community. We sought to understand the temporal relationship of AF and ischaemic stroke and to determine the sequence of disease onset in relation to mortality. Methods and results Across five prospective community cohorts of the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project we assessed baseline cardiovascular risk factors in 100 132 individuals, median age 46.1 (25th–75th percentile 35.8–57.5) years,

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Wang, Andrew, Abel N. Kho, and Dustin D. French. "Association of the Robert Wood Johnson Foundations’ social determinants of health and Medicare hospitalisations for ischaemic strokes: a cross-sectional data analysis." Open Heart 7, no. 1 (2020): e001189. http://dx.doi.org/10.1136/openhrt-2019-001189.

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ObjectiveSocial determinants of health (SDH) have previously demonstrated to be important risk factors in determining health outcomes. To document whether the SDH are associated with hospitalisations for ischaemic stroke.MethodsThis cross-sectional study examines data from fiscal year 2015. Patients from the national Medicare 100% Inpatient Limited Dataset were linked with SDH measures from the Robert Wood Johnson Foundation (RWJF) County Health Rankings. Medicare patients were included in the study group if they had either an admitting or primary diagnosis of ischaemic stroke. Counties withou

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Etherton, Mark R., Khawja A. Siddiqui, and Lee H. Schwamm. "Prestroke selective serotonin reuptake inhibitor use and functional outcomes after ischaemic stroke." Stroke and Vascular Neurology 3, no. 1 (2018): 9–16. http://dx.doi.org/10.1136/svn-2017-000119.

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BackgroundSelective serotonin reuptake inhibitors (SSRIs) have been implicated in contributing to recovery after acute ischaemic stroke. In particular, poststroke initiation of an SSRI has been demonstrated to improve motor recovery. The role of prestroke SSRI use on functional outcomes and stroke recovery is less clear. We aimed to examine the effect of prestroke SSRI use on metrics of hospitalisation and functional recovery.MethodsWe included 4968 consecutive patients from January 2006 to June 2015 in our local Get With The Guidelines-Stroke registry in whom a preadmission drug list could be

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Rachmawati, Mayori, Paulus Sugianto, and Rr Indrayuni Lukitra Wardhani. "LDL Level in Ischaemic Stroke Patients at Dr. Soetomo General Hospital Surabaya." Biomolecular and Health Science Journal 2, no. 1 (2019): 41. http://dx.doi.org/10.20473/bhsj.v2i1.12743.

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Introduction: Stroke is one of the top killers amongst the non-infectious diseases. Ischemic stroke dominates the rate by 87.0% amongst all type of strokes. One of the risk factors for stroke ischemic stroke is atherosclerosis which caused by lipid build-up in the arteries.Methods: This research is a retrospective study on secondary data. Admitted Ischaemic stroke patients. Lipid profile, and Barthel Index were collected from medical record and presented descriptively.Results: Of the 248 patients, 144 (58.1%) were men, mean age was 59.33. 61.7% ischemic stroke patients have their LDL level ele

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Rehni, Ashish K., Inderbir Singh, Nirmal Singh, and Manoj Kumar. "Stem Cells: Implications in Experimental Ischaemic Stroke Therapy." Stem Cell Reviews 4, no. 3 (2008): 227–33. http://dx.doi.org/10.1007/s12015-008-9025-1.

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Lucaci, Paul, Marius Neculaes, and Danisia Haba. "The Contribution of Imaging and Functional Diagnosis to the Rehabilitation of Patients with Stroke." Revista de Chimie 70, no. 8 (2019): 2847–50. http://dx.doi.org/10.37358/rc.19.8.7440.

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The research conducted is based on the clinical evaluation through magnetic resonance and on functional testing using the stabilometric platform, of a sample of 23 subjects with a stroke ischemic localised in the area of the middle cerebral artery. With the help of magnetic resonance, the structural changes of the ischaemic focus were determined. At the same time, the evolution in time of the ischaemia and the alteration at the level of the ischaemic area were monitored. By using the stabilometric platform GPS 400, the distribution of the load at the level of the lower limbs was analysed, as w

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Evans, Nicholas R., Jasmine Wall, Benjaman To, Stephen J. Wallis, Roman Romero-Ortuno, and Elizabeth A. Warburton. "Clinical frailty independently predicts early mortality after ischaemic stroke." Age and Ageing 49, no. 4 (2020): 588–91. http://dx.doi.org/10.1093/ageing/afaa004.

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Abstract Background Clinical frailty is an important syndrome for clinical care and research, independently predicting mortality and rates of institutionalisation in a range of medical conditions. However, there has been little research into the role of frailty in stroke. Objective This study investigates the effect of frailty on 28-day mortality following ischaemic stroke and outcomes following stroke thrombolysis. Methods Frailty was measured using the Clinical Frailty Scale (CFS) for all ischaemic stroke admissions aged ≥75 years. Stroke severity was measured using the National Institutes o

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Zlokovic, Berislav, John Griffin, and Laurent Mosnier. "Cytoprotective-selective activated protein C therapy for ischaemic stroke." Thrombosis and Haemostasis 112, no. 11 (2014): 883–92. http://dx.doi.org/10.1160/th14-05-0448.

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SummaryDespite years of research and efforts to translate stroke research to clinical therapy, ischaemic stroke remains a major cause of death, disability, and diminished quality of life. Primary and secondary preventive measures combined with improved quality of care have made significant progress. However, no novel drug for ischaemic stroke therapy has been approved in the past decade. Numerous studies have shown beneficial effects of activated protein C (APC) in rodent stroke models. In addition to its natural anticoagulant functions, APC conveys multiple direct cytoprotective effects on ma

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Mcneill, A. "How Accurate are Primary Care Referral Letters for Presumed Acute Stroke?" Scottish Medical Journal 53, no. 4 (2008): 11–12. http://dx.doi.org/10.1258/rsmsmj.53.4.11.

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The introduction of thrombolysis for the treatment of acute ischaemic stroke has increased the importance of prompt and accurate diagnosis. Research has shown a high rate of misdiagnosis of acute stroke in the community by paramedics and primary care doctors (PCDs). In this study, referral letters for presumed acute stroke or Transient Ischaemic Attack (TIA) were audited to assess the diagnostic accuracy of PCDs and the quality of the referral letters. In 30 % of cases, the diagnosis of stroke was correct. Important stroke mimics included sepsis, delirium and functional disorders. PCDs may ben

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Dawson, Jesse, Niall Broomfield, Krishna Dani, et al. "Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) – Protocol for a randomised double blind placebo-controlled clinical trial." European Stroke Journal 3, no. 3 (2018): 281–90. http://dx.doi.org/10.1177/2396987318771426.

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Background Allopurinol, a xanthine oxidase inhibitor, reduced progression of carotid-intima media thickness and lowered blood pressure in a small clinical trial in people with ischaemic stroke. Xanthine oxidase inhibition for improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) aims to assess the effect of allopurinol treatment on white matter hyperintensity progression and blood pressure after stroke. This paper describes the XILO-FIST protocol. Methods XILO-FIST is a multicentre randomised double-blind, placebo-controlled, parallel group cli

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Macrae, I. Mhairi, and Stuart M. Allan. "Stroke: The past, present and future." Brain and Neuroscience Advances 2 (January 2018): 239821281881068. http://dx.doi.org/10.1177/2398212818810689.

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Since the inception of the British Neuroscience Association, there have been major advances in our knowledge of the mechanistic basis for stroke-induced brain damage. Identification of the ischaemic cascade led to the development of hundreds of new drugs, many showing efficacy in preclinical (animal-based) studies. None of these drugs has yet translated to a successful stroke treatment, current therapy being limited to thrombolysis/thrombectomy. However, this translational failure has led to significant improvements in the quality of animal-based stroke research, with the refinement of rodent

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Chen, Mu-Hong, Tai-Long Pan, Cheng-Ta Li, et al. "Risk of stroke among patients with post-traumatic stress disorder: nationwide longitudinal study." British Journal of Psychiatry 206, no. 4 (2015): 302–7. http://dx.doi.org/10.1192/bjp.bp.113.143610.

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BackgroundPrevious evidence has shown positive associations between post-traumatic stress disorder (PTSD) and hypertension, dyslipidaemia and diabetes mellitus, which are all risk factors for stroke, but the role of PTSD in the subsequent development of stroke is still unknown.AimsTo investigate the temporal association between PTSD and the development of stroke.MethodIdentified from the Taiwan National Health Insurance Research Database, 5217 individuals aged 18 years, with PTSD but with no history of stroke, and 20 868 age- and gender-matched controls were enrolled between 2002 and 2009, and

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Wu, Simiao, Ruozhen Yuan, Yao Xiong, Shihong Zhang, Bo Wu, and Ming Liu. "Clinical features, management and outcomes of severe ischaemic stroke in tertiary hospitals in China: protocol for a prospective multicentre registry-based observational study." BMJ Open 8, no. 10 (2018): e024900. http://dx.doi.org/10.1136/bmjopen-2018-024900.

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IntroductionSevere ischaemic stroke is a devastating condition with high mortality and morbidity; however, there is insufficient evidence on its management. The aim of this study is to investigate causes, risk factors, clinical course, management and outcomes of severe ischaemic stroke in a real-world setting in tertiary hospitals in China.Methods and analysisThis is a prospective, multicentre, registry-based observational study. We will recruit 2500 patients with acute ischaemic stroke from nine tertiary hospitals in Western China. Patients with acute ischaemic stroke admitted to the Departme

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Wang, C. X., A. Stroink, J. M. Casto, and K. Kattner. "Hyperthermia Exacerbates Ischaemic Brain Injury." International Journal of Stroke 4, no. 4 (2009): 274–84. http://dx.doi.org/10.1111/j.1747-4949.2009.00317.x.

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Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.

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Best, Jonathan Gordon, Robert Bell, Mohammed Haque, Arvind Chandratheva, and David John Werring. "Atrial fibrillation and stroke: a practical guide." Practical Neurology 19, no. 3 (2019): 208–24. http://dx.doi.org/10.1136/practneurol-2018-002089.

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Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly intracranial haemorrhage. Atrial fibrillation management requires interdisciplinary collaboration with colleagues in cardiology and haematology. Recent advances, especially the now-widespread availability o

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Selvik, Henriette Aurora, Anna Therese Bjerkreim, Lars Thomassen, Ulrike Waje-Andreassen, Halvor Naess, and Christopher Elnan Kvistad. "When to Screen Ischaemic Stroke Patients for Cancer." Cerebrovascular Diseases 45, no. 1-2 (2018): 42–47. http://dx.doi.org/10.1159/000484668.

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Background and Purpose: Ischemic stroke can be the first manifestation of cancer and it is therefore important to ascertain which stroke patients should be considered for cancer-diagnostic investigations. We aimed to determine the frequency of active cancer in patients with acute ischemic stroke and to compare clinical findings in stroke patients with active cancer to ischemic stroke patients with no history of cancer. Finally, we aimed to develop a predictive and feasible score for clinical use to uncover underlying malignancy. Methods: All ischemic stroke patients admitted to the stroke unit

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McGreevy, Cora, Alan Moore, Ciaran Donegan, and David JP Williams. "Stroke thrombolysis in the very elderly." Reviews in Clinical Gerontology 20, no. 4 (2010): 261–67. http://dx.doi.org/10.1017/s0959259810000298.

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SummaryAcute ischaemic stroke is common in older people and is associated with a higher morbidity and mortality compared with younger patients. Intravenous thrombolysis with recombinant tissue plasminogen activator (r-tPA) has become the mainstay of treatment and is the only evidence-based specific treatment for acute ischaemic stroke. However, little data are available on the safety of thrombolysis in the over-80 years age group due to under-representation of this group in trials and the upper age limit for licensing of the drug. In this review, we look at the pathophysiology of stroke and re

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Zhang, Jing, Ping Zhu, Bingqing Liu, et al. "Time to recurrence after first-ever ischaemic stroke within 3 years and its risk factors in Chinese population: a prospective cohort study." BMJ Open 9, no. 12 (2019): e032087. http://dx.doi.org/10.1136/bmjopen-2019-032087.

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ObjectiveThis study aimed to estimate the time of recurrent ischaemic stroke events among the first 3 years of follow-up after hospitalisation discharge.Study designA prospective cohort study.SettingThe research was conducted in the Department of Neurology at a tertiary hospital, Chengdu of China, from January 2010 to June 2016.Outcome measuresWe estimated the restricted mean survival time (RMST) of ischaemic stroke recurrence for the first 3 years after discharge. Basic sociodemographic characteristics and major potential risk factors for recurrence were collected using a semistructured quest

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Hayreh, Sohan Singh. "Controversies on neuroprotection therapy in non-arteritic anterior ischaemic optic neuropathy." British Journal of Ophthalmology 104, no. 2 (2019): 153–56. http://dx.doi.org/10.1136/bjophthalmol-2019-314656.

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ObjectiveThere has long been a great interest in neuroprotection therapy for ischaemic stroke and various types of optic neuropathies. In view of that, I reviewed the literature on the role of neuroprotection for non-arteritic anterior ischaemic optic neuropathy (NA-AION).MethodsThe review is based on a PubMed search of literature about the use of neuroprotectors in stroke and optic neuropathies and about current clinical trials of RPh201 and QPI-1007 in NA-AION.ResultsSeveral neuroprotection agents for ischaemic stroke and various types of optic neuropathies have been evaluated extensively in

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Suo, Yue, Jing Jing, Xia Meng, et al. "Inconsistent centralised versus non-centralised ischaemic stroke aetiology." Stroke and Vascular Neurology 5, no. 4 (2020): 337–47. http://dx.doi.org/10.1136/svn-2020-000576.

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Background and purposeThe Trial of Org 10 172 in Acute Stroke Treatment (TOAST) system is the most widely used aetiological categorisation system in clinical practice and research. Limited studies have validated the accuracy of routine aetiological diagnosis of patients with ischaemic stroke according to the TOAST criteria when the reported subtype is assumed to be correct. We investigated the agreement between centralised and non-centralised (site-reported, at discharge) stroke subtypes in the Third China National Stroke Registry (CNSR-III), and analysed the influence of classification consis

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Liu, Liping, Jing Ding, Xinyi Leng, et al. "Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017." Stroke and Vascular Neurology 3, no. 3 (2018): 117–30. http://dx.doi.org/10.1136/svn-2017-000135.

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Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute, subacute or chronic phases after an ischaemic stroke or transient ischaemic attack. Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment. Over the past decade, the importance of collateral circulation has attracted more attention and is becoming a hot spot for research. However, the diversity in imaging methods and criteria to ev

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Bath, Philip M., Lisa J. Woodhouse, Jason P. Appleton, et al. "Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT." Health Technology Assessment 22, no. 48 (2018): 1–76. http://dx.doi.org/10.3310/hta22480.

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BackgroundTwo antiplatelet agents are better than one for preventing recurrent stroke after acute ischaemic stroke or transient ischaemic attack (TIA). Therefore, intensive treatment with three agents might be better still, providing it does not cause undue bleeding.ObjectiveTo compare the safety and efficacy of intensive therapy with guideline antiplatelet therapy for acute ischaemic stroke and TIA.DesignInternational prospective randomised open-label blinded end-point parallel-group superiority clinical trial.SettingAcute hospitals at 106 sites in four countries.ParticipantsPatients > 50

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Urimubenshi, Gerard, Peter Langhorne, Dominique A. Cadilhac, Jeanne N. Kagwiza, and Olivia Wu. "Association between patient outcomes and key performance indicators of stroke care quality: A systematic review and meta-analysis." European Stroke Journal 2, no. 4 (2017): 287–307. http://dx.doi.org/10.1177/2396987317735426.

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Purpose Translating research evidence into clinical practice often uses key performance indicators to monitor quality of care. We conducted a systematic review to identify the stroke key performance indicators used in large registries, and to estimate their association with patient outcomes. Method We sought publications of recent (January 2000–May 2017) national or regional stroke registers reporting the association of key performance indicators with patient outcome (adjusting for age and stroke severity). We searched Ovid Medline, EMBASE and PubMed and screened references from bibliographies

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Kaur, Inderjeet, Ashok Khurana, Jasmine Kaur Sachdev, and Gurinder Mohan. "Evaluation of serum uric acid in acute ischaemic stroke." International Journal of Advances in Medicine 4, no. 1 (2017): 60. http://dx.doi.org/10.18203/2349-3933.ijam20170036.

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Background: The role of serum uric acid as a risk factor for acute ischaemic stroke is controversial and there is little information about it. Present study was done to estimate serum uric acid levels in patients of acute ischaemic stroke and to assess its risk factor potential.Methods: It was a prospective case control study carried out in the department of Medicine at Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Sri Amritsar, Punjab, India from January 2015 to July 2016. 50 cases of acute ischaemic stroke were enrolled and were compared with same number of age and sex

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Wan Zain, Wan Mohd Saifuhisam, Julia Omar, Tuan Salwani Tuan Ismail, and Noor Azlin Azraini Che Soh. "Acute Ischaemic Stroke With Hyperprolactinemia:A Case Report." Journal of the Endocrine Society 5, Supplement_1 (2021): A570. http://dx.doi.org/10.1210/jendso/bvab048.1162.

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Abstract Background: Macroincidentalomas were reported in 0.2% of patient underwent imaging (CT scans) for central nervous symptoms (1). In acute ischaemic stroke with hyperprolactinemia, the diagnosis of a double pathology of ischemic stroke and sellar tumour especially prolactinoma need to be considered. Hyperprolactinemia itself may be considered as a risk factor for ischemic stroke due to its thrombogenic effect (3). Clinical Case: A 47-year old man underlying hypertension and diabetes mellitus for 5 years presented with sudden onset of right sided body weakness associated with facial asym

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Wu, Victor Chien-Chia, Michael Wu, Victor Aboyans, et al. "Female sex as a risk factor for ischaemic stroke varies with age in patients with atrial fibrillation." Heart 106, no. 7 (2019): 534–40. http://dx.doi.org/10.1136/heartjnl-2019-315065.

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ObjectivesFemale sex is an inconsistent ischaemic stroke risk factor in patients with atrial fibrillation (AF). We hypothesised that the ischaemic stroke risk varies with age among women compared with men.MethodsWe retrieved the patients with newly diagnosed AF during 2001–2013 from Taiwan’s National Health Insurance Research Database. Patients with missing information, age <20 years, history of valvular heart disease and surgery, rheumatic heart disease, hyperthyroidism or anticoagulation and/or antiplatelet use were excluded. Propensity score matching (PSM) included patient comorbidities,

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Reiff, Tilman, Christoph Gumbinger, Sibu Mundiyanapurath, and Peter A. Ringleb. "Update on Extracranial Carotid Stenosis." European Neurological Review 11, no. 1 (2016): 18. http://dx.doi.org/10.17925/enr.2016.11.01.18.

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Carotid stenosis is a risk factor of ischaemic stroke and has an increasing prevalence with age. Stroke risk under optimised medical therapy, as well as recommendations of carotid artery endarterectomy/stenting, as therapy in high risk carotid stenosis, are discussed in consideration of recent research results.

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deVeber, G. "Paediatric stroke." Hämostaseologie 29, no. 01 (2009): 88–90. http://dx.doi.org/10.1055/s-0037-1616948.

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SummaryThe past decade has seen a dramatic increase in pediatric stroke research. However few studies have addressed anti-thrombotic safety or effectiveness. Three paediatric stroke guidelines combining research data with expert consensus have been published in the past five years. For most patients treatment recommendations are consistent. Newborns with arterial ischaemic stroke (AIS) rarely require antithrombotic treatment given their extremely low risk of recurrence. In children with AIS a substantial recurrence risk means that antithrombotic treatment is required unless contraindicated. An

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Robak, Tadeusz, Joanna Góra-Tybor, Krzysztof Tybor, et al. "Richter's Syndrome in the Brain First Manifested as an Ischaemic Stroke." Leukemia & Lymphoma 45, no. 6 (2004): 1261–67. http://dx.doi.org/10.1080/10428190310001638823.

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Zhang, Haojie, Zixiao Li, Yunyi Dai, Enhui Guo, Changqing Zhang, and Yongjun Wang. "Ischaemic stroke etiological classification system: the agreement analysis of CISS, SPARKLE and TOAST." Stroke and Vascular Neurology 4, no. 3 (2019): 123–28. http://dx.doi.org/10.1136/svn-2018-000226.

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Background and purposeThe ideal stroke classification system needs to have validity, high reliability and applicability among different stroke research settings. The Chinese Ischemic Stroke Subclassification (CISS) and the Subtypes of Ischemic Stroke Classification System (SPARKLE) have emerged recently but have not been tested using agreement analysis. As a result, the objective of this study is to investigate the level of agreement among stroke subtype classifications using CISS, SPARKLE and Trial of Org 10172 in Acute Stroke Treatment (TOAST). We also analyse the inter-rater reliability of

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Gupta, Navnika, and Sanjay Pandey. "Post-Thalamic Stroke Movement Disorders: A Systematic Review." European Neurology 79, no. 5-6 (2018): 303–14. http://dx.doi.org/10.1159/000490070.

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Background: After a stroke, movement disorders are rare manifestations mainly affecting the deep structures of the brain like the basal ganglia (44%) and thalamus (37%), although there have been case studies of movement disorders in strokes affecting the cerebral cortex also. Summary: This review aims to delineate the various movement disorders seen in association with thalamic strokes and tries to identify the location of the nuclei affected in each of the described movement disorders. Cases were identified through a search of PubMed database using different search terms related to post-thala

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Buchtele, Nina, Michael Schwameis, James Gilbert, Christian Schörgenhofer, and Bernd Jilma. "Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence." Thrombosis and Haemostasis 118, no. 06 (2018): 959–78. http://dx.doi.org/10.1055/s-0038-1648251.

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AbstractDespite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges between vascular sub-endothelial collagen and platelets. The rationale for vWF as a potential target in stroke comes from four bodies of evidence. (1) Animal models which recapitulate the pathogenesis of stroke and validate the concept of targeting vWF for stroke preventio

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Hildick-Smith, David, Ulf Landmesser, A. John Camm, et al. "Left atrial appendage occlusion with the Amplatzer™ Amulet™ device: full results of the prospective global observational study." European Heart Journal 41, no. 30 (2020): 2894–901. http://dx.doi.org/10.1093/eurheartj/ehaa169.

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Abstract Aims To evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) with the Amplatzer™ Amulet™ occluder. Methods and results Patients with atrial fibrillation eligible for LAAO were recruited to a prospective global study. Implant procedures were undertaken with echocardiographic guidance. Transoesophageal echocardiography (TOE) was undertaken 1–3 months post-LAAO. Implant and follow-up TOEs were evaluated by a CoreLab. The primary endpoint was a composite of ischaemic stroke and cardiovascular death at 2 years. Serious adverse events were adjudicated by an independent

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Li, Ce, Tingting Zhang, Kewei Yu та ін. "Neuroprotective Effect of Electroacupuncture and Upregulation of Hypoxia-Inducible Factor-1α during Acute Ischaemic Stroke in Rats". Acupuncture in Medicine 35, № 5 (2017): 360–65. http://dx.doi.org/10.1136/acupmed-2016-011148.

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Background Acupuncture is a traditional method that has been widely used in various fields of medicine with therapeutic effect. However, evidence of effectiveness to support the application of electroacupuncture (EA) during the process of ischaemia is scarce. Objectives To investigate dynamic changes in hypoxia-inducible factor (HIF)-1α expression as well as its association with neurological status in rats subjected to acute ischaemic stroke and EA intervention. Methods Forty adult male rats were randomly divided into three groups that received sham surgery (Control group, n=10) or underwent m

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Williams, A., M. Sittampalam, N. Barua, and A. Mohd Nor. "Case Series of Post-Thrombolysis Patients Undergoing Hemicraniectomy for Malignant Anterior Circulation Ischaemic Stroke." Cardiovascular Psychiatry and Neurology 2011 (April 18, 2011): 1–4. http://dx.doi.org/10.1155/2011/254569.

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While ischaemic stroke remains a leading cause of death and disability, there have been recent advancements in treatment modalities including thrombolysis and decompressive hemicraniectomy. A retrospective review of patients treated in our NHS teaching hospital, in Plymouth (UK), over a 2 year period identified 17 thrombolysed patients, of whom two had undergone subsequent decompressive hemicraniectomy. These were non-dominant hemisphere strokes in young patients, aged 51 and 57. Initial NIHSS scores were 16 and 17, and they received thrombolysis at 2 hrs 42 min and 5 hrs 10 min post onset of

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Venema, Esmee, Martijne H. C. Duvekot, Hester F. Lingsma, et al. "Prehospital triage of patients with suspected stroke symptoms (PRESTO): protocol of a prospective observational study." BMJ Open 9, no. 7 (2019): e028810. http://dx.doi.org/10.1136/bmjopen-2018-028810.

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IntroductionThe efficacy of both intravenous treatment (IVT) and endovascular treatment (EVT) for patients with acute ischaemic stroke strongly declines over time. Only a subset of patients with ischaemic stroke caused by an intracranial large vessel occlusion (LVO) in the anterior circulation can benefit from EVT. Several prehospital stroke scales were developed to identify patients that are likely to have an LVO, which could allow for direct transportation of EVT eligible patients to an endovascular-capable centre without delaying IVT for the other patients. We aim to prospectively validate

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Harshfield, Eric L., Matthew C. Sims, Matthew Traylor, Willem H. Ouwehand, and Hugh S. Markus. "The role of haematological traits in risk of ischaemic stroke and its subtypes." Brain 143, no. 1 (2019): 210–21. http://dx.doi.org/10.1093/brain/awz362.

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Abstract Thrombosis and platelet activation play a central role in stroke pathogenesis, and antiplatelet and anticoagulant therapies are central to stroke prevention. However, whether haematological traits contribute equally to all ischaemic stroke subtypes is uncertain. Furthermore, identification of associations with new traits may offer novel treatment opportunities. The aim of this research was to ascertain causal relationships between a wide range of haematological traits and ischaemic stroke and its subtypes. We obtained summary statistics from 27 published genome-wide association studie

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Joo, Heesoo, Guijing Wang, and Mary G. George. "A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke." Stroke and Vascular Neurology 2, no. 2 (2017): 73–83. http://dx.doi.org/10.1136/svn-2016-000063.

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BackgroundIntravenous recombinant tissue plasminogen activator (IV rtPA) is recommended treatment for patients with acute ischaemic stroke, but the cost-effectiveness of IV rtPA within different time windows after the onset of acute ischaemic stroke is not well reviewed.AimsTo conduct a literature review of the cost-effectiveness studies about IV rtPA by treatment times.Summary of reviewA literature search was conducted using MEDLINE, EMBASE, CINAHL and Cochrane Library, with the keywords acute ischemic stroke, tissue plasminogen activator, cost, economic benefit, saving and incremental cost-e

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Wang, Yongjun, Zixiao Li, Yilong Wang, et al. "Chinese Stroke Center Alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings." Stroke and Vascular Neurology 3, no. 4 (2018): 256–62. http://dx.doi.org/10.1136/svn-2018-000154.

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BackgroundIn June 2015, the Chinese Stroke Association (CSA) initiated the Chinese Stroke Center Alliance (CSCA) to establish the national hospital-based stroke care quality assessment and improvement platform. This article outlines its objectives, operational structure, patient population, quality improvement (QI) intervention tools, data elements, data collection methodology and current patient and hospital data.MethodsThe CSCA is a national, hospital-based, multicentre, voluntary, multifaceted intervention and continuous QI initiative. This multifaceted intervention includes stroke centre d

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