Relevant bibliographies by topics / Ischemia – Complications

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  1. Journal articles
  2. Dissertations / Theses
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  5. Conference papers

Academic literature on the topic 'Ischemia – Complications'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Ischemia – Complications"

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Bolshedvorskaya, O. A., K. V. Protasov, Yu K. Batoroev, P. S. Ulybin, and V. V. Dvornichenko. "Postoperative Cardiac Ischemic Complications in Lung Cancer Patients." Acta Biomedica Scientifica 4, no. 5 (2019): 91–97. http://dx.doi.org/10.29413/abs.2019-4.5.15.

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Background. Perioperative myocardial ischemia often complicates extracardiac surgery. The problems of its prediction, diagnostics, treatment and prevention are not solved. Frequency, structure and clinical features of cardiac ischemic complications of surgical treatment of lung cancer are not well understood.The aim of the study was to investigate the frequency of postoperative myocardial infarction and myocardial ischemia in the surgical treatment of patients with non-small cell lung cancer.Methods. The frequency (%) of myocardial infarction (MI) with and without ST segment elevation of electrocardiogram, acute myocardial ischemia in a complete sample of cancer patients (n = 2051) who underwent treatment for non-small cell lung cancer for the last 10 years was calculated. By comparing the relative indicators and calculating the Odds Ratio (OR), we studied the relationship between the cardiac ischemic events with age, type of surgery, prevalence and localization of the tumour. The clinical manifestations and pathomorphology of postoperative myocardial infarction were analysed.Results. Cardiac ischemic complications of thoracotomy for lung cancer occurred in 2.73 % (95% CI 1.98–3.48) cases. Myocardial infarction with ST segment elevation was recorded in 1.07 % (95% CI 0.58–1.57) patients, MI without ST segment elevation – in 0.54 % (95% CI 0.17–0.9), myocardial ischemia – in 1.12 % (95% CI 0.62–1.63). An increase in the frequency of ischemic events after pneumonectomy was observed compared with lobectomy (OR 6.5, 95% CI 3.5–12.2) and after right-sided pneumonectomy compared with left-sided one (OR 3.2, 95% CI 1.6–6.3), and also the age over 70. Hospital mortality from MI was 39.3 %. According to autopsies of patients who died of МI, coronary atherothrombosis was detected in 2 of 22 cases.Conclusion. In the surgical treatment of non-small cell lung cancer, cardiac ischemic events develop in 2.73 % of patients. The greatest risk is associated with right-sided pneumonectomy.
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Zhao, Meng, Xiaofeng Deng, Dong Zhang, et al. "Risk factors for and outcomes of postoperative complications in adult patients with moyamoya disease." Journal of Neurosurgery 130, no. 2 (2019): 531–42. http://dx.doi.org/10.3171/2017.10.jns171749.

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OBJECTIVEThe risk factors and clinical significance of postoperative complications in moyamoya disease are still unclear. The aim of this study was to investigate the predictors of postoperative complications in moyamoya disease and examine the impact of complications on outcomes.METHODSThe authors reviewed consecutive cases involving adult moyamoya disease patients who underwent indirect, direct, or combined bypass surgery in their hospital between 2009 and 2015. Preoperative clinical characteristics and radiographic features were recorded. Postoperative complications within 14 days after surgery were examined. Multivariate logistic regression analyses were performed to identify the risk factors for either postoperative ischemia or postoperative cerebral hyperperfusion. Outcome data, including recurrent strokes and neurological status (modified Rankin Scale [mRS]) during follow-up, were collected. Outcomes were compared between patients who had complications with those without complications, using propensity-score analysis to account for between-group differences in baseline characteristics.RESULTSA total of 500 patients (610 hemispheres) were included in this study. Postoperative complications were observed in 74 operations (12.1%), including new postoperative ischemia in 30 cases (4.9%), hyperperfusion in 27 (4.4%), impaired wound healing in 12 (2.0%), and subdural effusion in 6 (1.0%). The complication rates for different surgery types were as follows: 12.6% (n = 25) for indirect bypass, 12.7% (n = 37) for direct bypass, and 10.0% (n = 12) for combined bypass (p = 0.726). Postoperative ischemic complications occurred in 30 hemispheres (4.9%) in 30 different patients, and postoperative symptomatic hyperperfusion occurred after 27 procedures (4.4%). Advanced Suzuki stage (OR 1.669, 95% CI 1.059–2.632, p = 0.027) and preoperative ischemic presentation (OR 5.845, 95% CI 1.654–20.653, p = 0.006) were significantly associated with postoperative ischemia. Preoperative ischemic presentation (OR 5.73, 95% CI 1.27–25.88, p = 0.023) and admission modified Rankin Scale (mRS) score (OR 1.81, 95% CI 1.06–3.10, p = 0.031) were significantly associated with symptomatic postoperative cerebral hyperperfusion syndrome (CHS). Compared with patients without postoperative complications, patients who experienced any postoperative complications had longer hospital stays and worse mRS scores at discharge (both p < 0.0001). At the final follow-up, no significant differences in functional disability (mRS score 3–6, 11.9% vs 4.5%, p = 0.116) and future stroke events (p = 0.513) between the 2 groups were detected.CONCLUSIONSAdvanced Suzuki stage and preoperative ischemic presentation were independent risk factors for postoperative ischemia; the mRS score on admission and preoperative ischemic presentation were independently associated with postoperative CHS. Although patients with postoperative complications had worse neurological status at discharge, postoperative complications had no associations with future stroke events or functional disability during follow-up.
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Hillberg, Nadine S., Jop Beugels, Sander M. J. van Kuijk, René R. J. W. van der Hulst, and Stefania M. H. Tuinder. "Increase of major complications with a longer ischemia time in breast reconstruction with a free deep inferior epigastric perforator (DIEP) flap." European Journal of Plastic Surgery 43, no. 2 (2019): 133–38. http://dx.doi.org/10.1007/s00238-019-01584-0.

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Abstract Background The deep inferior epigastric artery perforator (DIEP) flap is one of the most used free flaps for postmastectomy breast reconstruction. Prolonged ischemia can result in (partial) flap loss. The aim of this study was to evaluate the association between ischemia time and postoperative complications of DIEP flap breast reconstruction. Methods A retrospective study of all patients who received a breast reconstructionwith aDIEP flap atMaastricht University Medical Center in theNetherlands, between January 2010 and June 2017 (n = 677). The flaps were divided into two groups: flaps with an ischemia time less than 60 min and those with 60 min or more. Recipient site complications, in particular major complications equal to re-exploration, and partial or total flap loss were the primary outcome measures. Results In 23.9% of the 677 included DIEP flaps, the ischemia time was 60 min or longer. Within this group, a complication of the recipient site occurred in 30.9% of the flaps. A major complication occurred in 17.3% of the flaps with 60 min or more ischemia time.With regard to the flaps with less than 60-min ischemia time, a complication occurred in 22.1% of the cases of which 8.9%would be considered amajor complication. A significant association was found between ischemia time and major complications on univariate (p value = 0.003) and multivariate analyses (p value = 0.016). Conclusions This study demonstrates that an ischemia time less than 60 min is associated with a significantly lower risk of major recipient site complications compared to an ischemia time of 60 min or more. Level of evidence: Level III, therapeutic, risk/prognostic study.
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Afrin, Syeda Fahmida, Md Hasanur Rahman, Md Asadul Millat, Md Shafiul Alam Quarashi, Asma Begum, and Meherunnesa Begum. "Minor Myocardial Injury: An Early Post Intervention Complication." Delta Medical College Journal 5, no. 2 (2017): 94–98. http://dx.doi.org/10.3329/dmcj.v5i2.33348.

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Percutaneous Coronary Intervention (PCI) is the most commonly performed invasive therapeutic cardiac procedure and plays an important role in the treatment of ischemic heart disease. Complications of Percutaneous Coronary Intervention (PCI) are relatively infrequent. The most common complications include discomfort and bleeding at the puncture site where the catheter was inserted. Major complications include death, MI, or stroke and other infrequent complications include transient ischemic attacks (minor myocardial injury), vascular complication and contrast induced nephropathy, transient ischemia, or minor myocardial injury (MMI), myocardial necrosis due to compromisation of threatened coronary circulation during balloon inflation. Cardiac Troponin I (cTnI) assays for the assessment of myocardial injury has been demonstrated for the diagnosis of MMI and long term prognosis after PCI.Delta Med Col J. Jul 2017 5(2): 94-98
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Brinjikji, Waleed, Jonathan M. Morris, Robert D. Brown, et al. "Neuroimaging Findings in Cardiac Myxoma Patients: A Single-Center Case Series of 47 Patients." Cerebrovascular Diseases 40, no. 1-2 (2015): 35–44. http://dx.doi.org/10.1159/000381833.

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Background and Purpose: Cardiac myxomas can present with a myriad of neurological complications including stroke, cerebral aneurysm formation and metastatic disease. Our study had two objectives: (1) to describe the neuroimaging findings of patients with cardiac myxomas and (2) to examine the relationship between a history of embolic complications secondary to myxoma and intracranial aneurysm formation, hemorrhage and metastatic disease. We hypothesized that patients who present with embolic complications related to myxoma would be more likely to have such complications. Materials and Methods: We searched our institutional database for all patients with pathologically proven cardiac myxomas from 1995 to 2014 who received neuroimaging. Neuroimaging findings were categorized as acute ischemic stroke, intracerebral hemorrhage, oncotic aneurysm, and cerebral metastasis. Cardiac myxoma patients were divided into those presenting with embolic complications (i.e. lower extremity emboli or cerebral emboli) and those presenting with non-embolic complications prior to surgical resection of the myxoma. The prevalence of intracranial hemorrhage, myxomatous aneurysm formation, and cerebral metastases was compared in myxoma patients presenting with and without embolic complications using a Chi-squared test. Results: Forty-seven consecutive patients were included in this study. Sixteen patients (34.0%) had imaging evidence of acute ischemic stroke. Of these, 13 had acute ischemic strokes directly attributed to the cardiac myxoma (27.7%) and 3 had acute ischemic strokes secondary to causes other than myxoma (6.4%). Seven patients (14.9%) had aneurysms. Two patients (4.3%) had parenchymal metastatic disease on long-term imaging. Fourteen patients (29.8%) presented with ischemic symptoms that were attributed to cardiac myxoma (1 with lower extremity ischemia, 1 with lower extremity ischemia and ischemic stroke, and 12 with ischemic stroke). Patients presenting with embolic complications related to the myxoma (ischemic stroke or lower extremity ischemia) were more likely to have imaging evidence of intracranial hemorrhage (21.4 vs. 3.0%, p = 0.09), oncotic aneurysm (35.7 vs. 6.1%, p = 0.03), and cerebral metastasis (14.3 vs. 0.0%, p = 0.07) on follow-up imaging. Conclusions: Ischemic stroke and intracranial oncotic aneurysm were found in a substantial proportion of cardiac myxoma patients undergoing neuroimaging. Patients presenting with embolic complications of cardiac myxoma are more likely to have intracranial hemorrhage, intracranial oncotic aneurysms, and cerebral metastatic disease.
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Christenson, Jan T., Jorge Sierra, Jacques-André Romand, Marc Licker, and Afksendyios Kalangos. "Long Intraaortic Balloon Treatment Time Leads to More Vascular Complications." Asian Cardiovascular and Thoracic Annals 15, no. 5 (2007): 408–12. http://dx.doi.org/10.1177/021849230701500510.

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Intraaortic balloon counterpulsation is an established and efficient therapy. Limb ischemia is the most common complication. The impact of treatment duration on balloon-related complications was analyzed retrospectively in 135 patients who underwent balloon counterpulsation between 1998 and 2004. Thirty high-risk coronary patients required preoperative intraaortic balloon therapy, 41 were in preoperative cardiogenic shock, and 64 needed support for difficulties in weaning from cardiopulmonary bypass. No balloon-related mortality occurred. The overall balloon-related complication rate was 20/135 (14.8%); 18 had limb ischemia, of whom 6 (4.4%) required vascular interventions. Intraaortic balloon treatment time was significantly longer in patients who developed limb ischemia (99.8 ± 54.1 h) compared to those who did not (34.4 ± 30.4 h). Preoperative therapy had short treatment times and few complications. Intraaortic balloon pumping provides effective circulatory support with a low complication rate. A clear relationship was established between duration of treatment and balloon-related complications. Independent risk factors for balloon-related complications were long treatment time, acute myocardial infarction, age over 65 years, and ejection fraction less than 0.30.
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Park, Dong Soo, Jin Ho Hwang, Moon Hyung Kang, and Jong Jin Oh. "Association between R.E.N.A.L nephrometry score and perioperative outcomes following open partial nephrectomy under cold ischemia." Canadian Urological Association Journal 8, no. 3-4 (2014): 137. http://dx.doi.org/10.5489/cuaj.1372.

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Introduction: We investigate the clinical significance of the R.E.N.A.L. nephrometry score for renal neoplasm following open partial nephrectomy (PN) under cold ischemia.Methods: A retrospective analysis was conducted using clinical data of 98 consecutive patients with clear cell renal cell carcinoma who underwent open PN by a single surgeon from December 2000 to September 2012. Tumour complexity was stratified into 3 categories: low (4-6), moderate (7-9) and high (10-12) complexity. Perioperative outcomes, such as complications, cold ischemic time, estimated blood loss and renal function, were analyzed according to the complexity by NS. Complications were stratified using the Clavien-Dindo classification system.Results: Tumour complexity according to nephrometry score was assessed as low in 16 (16.3%), moderate in 48 (49.0%) and high in 34 (34.7%). The median cold ischemic time did not differ significantly among the 3 groups (36.0 minutes in low-, 40 minutes in moderate- and 43 minutes in the high-complexity group, p = 0.421). Total complications did not differ significantly (2 (2.0%) in low, 4 (4.1%) in moderate and 4 (4.1%) in high, p = 0.984). Each Grade 3 complication occurred in the moderate (urine leakage) and high groups (lymphocele). Postoperative renal functional outcomes were similar among the groups (p = 0.729). Only mean estimated blood loss was significantly different with nephrometry score (p = 0.049).Conclusions: The nephrometry score, as used in an open PN series under cold ischemia, was not significantly associated with perioperative outcomes (i.e., ischemia time, complications, renal functional preservation).
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Von Blotzheim, S. Glutz, and F. X. Borruat. "Neuro-Ophthalmic Complications of Biopsy-Proven Giant Cell Arteritis." European Journal of Ophthalmology 7, no. 4 (1997): 375–82. http://dx.doi.org/10.1177/112067219700700412.

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Purpose To define the spectrum of neuro-ophthalmic complications and clinical presentations of patients with giant cell arteritis (GCA). Methods Retrospective study (1977-1994) of clinical charts, fundus photographies and fluorescein angiographies of 66 patients with temporal artery biopsy positive for GCA. Results Clinical data were adquate for 47 patients. Headaches were reported by 83%, weight loss in 73%, jaw claudication in 68%, scapular pain in 64% and asthenia in 57%. Erythrocyte sedimentation rate was normal in 15%. Neuro-ophthalmic complications were present in 33 cases (70%), including anterior ischemic optic neuropathy (22 cases), choroidal ischemia (17 cases), central or branch retinal artery occlusion (seven cases), and oculomotility disturbances (four cases). Fluorescein angiography was very helpful for detecting choroidal ischemia (80.9% of our cases). Twenty-one patients presented with involvement of several distinct orbital arterial territories and one very unusual patient suffered from an orbital infarction (i.e. ischemia of all orbital structures). Conclusions In our series, two-thirds of biopsy-proven GCA patients presented with neuro-ophthalmic complications, ranging from transient visual loss to orbital infarction. Involvement of more than one orbital vascular territory is highly suggestive of an arteritic process. Clinicians should keep in mind the possibility of GCA even when ESR is normal, and fluorescein angiography should be performed. The finding of choroidal ischemia should prompt temporal artery biopsy and steroid therapy.
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Stewart, Jill, and Gary H. Bouley. "Cardiopulmonary Complications of Ischemia-Reperfusion Injury." American Journal of Nursing 100, no. 5 (2000): 42. http://dx.doi.org/10.2307/3521779.

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Stewart, Jill, and Gary H. Bouley. "Cardiopulmonary Complications of Ischemia-Reperfusion Injury." AJN, American Journal of Nursing &NA;, Supplement (2000): 42–46. http://dx.doi.org/10.1097/01.naj.0000370971.34624.78.

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Dissertations / Theses on the topic "Ischemia – Complications"

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Winnerkvist, Anders. "Management of thoracoabdominal aortic aneurysms and dissections : with emphasis on spinal cord protection in aneurysm repair and non-surgical treatment of type-B dissection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-768-5/.

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Patouraux, Stéphanie. "Rôle de l'ostéopontine dans les complications hépatiques induites par l'alcool, l'obésité et l'ischémie-reperfusion." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4134/document.

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L’ostéopontine (OPN) est une protéine synthétisée et sécrétée par de nombreux types cellulaires. Elle joue un rôle important dans la régulation de la réponse inflammatoire et immune. Elle est également pro-fibrogénique, et présente des propriétés anti-apoptiques. Les NAFLD et ALD sont les premières causes d’ hépatopathies en France. Le spectre de ces complications va de la stéatose à la stéatohépatite, la fibrose, la cirrhose voire le carcinome hépatocellulaire. Le tissu adipeux joue un rôle important dans la survenue et l’évolution des NAFLD. Nous montrons que l'OPN favorise l'inflammation du foie et du tissu adipeux dans les NAFLD, en favorisant le recrutement de macrophages, de cellules dendritiques et de lymphocytes T et en modulant la polarisation de ces cellules immunes. Chez les patients alcooliques, nous rapportons que l’OPN constitue un marqueur prédictif de la fibrose hépatique. Les lésions induites par l'IR hépatique sont la principale cause de dommages survenant au cours des chirurgies du foie. Le rôle de l'OPN lors de l’IR n’a pas été étudié dans le foie. Mes études ont mis en évidence que l'OPN pourrait jouer un rôle protecteur. Son invalidation (OPN-/-) aggrave les lésions hépatiques (inflammation, souffrance et nécrose hépatocytaire) induites par l’IR chez la souris. Ce rôle protecteur de l’OPN pourrait être dû à sa capacité à prévenir la mort hépatocytaire et à limiter la production toxique de NO dans les macrophages. L’ensemble de ces travaux a permis de mettre en évidence de nouveaux rôles de l'OPN dans les lésions induites par l'IR hépatique et pourrait constituer une cible thérapeutique pour les maladies chroniques du foie<br>Osteopontin (OPN) is a protein synthesized and secreted by many different types of cells. It plays an important part in the regulation of the inflammatory and immune response. OPN is also pro-fibrogenic, and has anti-apoptotic properties. The nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the leading causes of liver disease in France. The range of these complications goes from steatosis to steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma. Adipose tissue plays a significant part on the occurrence and evolution of the NAFLD. We show that OPN facilitates liver’s and adipose tissue’s inflammation in the NAFLD, by facilitating the intake of macrophages, dendritic cells and T cells, and by modulating the polarization of these immune cells. For alcoholic patients, we show that OPN is one of the predictive markers of liver fibrosis. The lesions induced by ischemia-reperfusion (IR) are the main cause of damages occurring during liver’s surgery. The role of OPN in hepatic injury induced by IR has not yet been investigated. My studies demonstrate that OPN could have a protecting role. OPN deficiency in mice (OPN-/-) increases hepatic lesions caused by IR (inflammation, and cell death). OPN could thus partially prevent hepatic injury and inflammation induced by IR. This could be due to its ability to prevent hepatocyte death and production of toxic NO by macrophages. OPN could thus be an important actor in the pathogenesis of chronic liver disease
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Kragsterman, Björn. "Carotid artery stenosis : surgical aspects /." Uppsala : Acta Universitatis Upsaliensis : Univ.bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6834.

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Nseir, Saadalla. "Prévention des microinhalations et de l'ischémie trachéale liées à l'intubation : rôle de la régulation continue de la pression du ballonnet." Phd thesis, Université du Droit et de la Santé - Lille II, 2011. http://tel.archives-ouvertes.fr/tel-00743346.

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La sonde d'intubation est le facteur de risque principal des microinhalations. Sa présence empêche la fermeture des cordes vocales, favorisant ainsi la progression des sécrétions oropharyngées vers les voies respiratoires inférieures. Le ballonnet de la sonde trachéale prévient en partie cette microinhalation, mais la présence de microsillons sur les ballonnets en polyvinyl chloride (PVC) et la souspression du ballonnet (<20 cmH2O) favorisent les microinhalations autour du ballonnet. Alors que lésions ischémiques trachéales sévères liées à l'intubation ne sont pas fréquentes, elles sont associées à une morbidité et une mortalité élevées. Leurs principaux facteurs de risque sont la surpression du ballonnet trachéal (>30 cmH2O) et la durée de l'intubation. Hypothèse Malgré les précautions habituelles consistant à réguler la Pbal 3 fois par jour avec un manomètre manuel, les souspressions et surpressions du ballonnet trachéal sont probablement fréquentes. Si tel est le cas la régulation continue de la Pbal avec un régulateur de pression pneumatique permettrait de prévenir les microinhalations et l'ischémie trachéale liées à l'intubation. 1.Déterminer l'incidence et les facteurs de risque de souspression et de surpression du ballonnet trachéal chez les patients de réanimation. 2.Déterminer l'impact du matériau et de la forme du ballonnet sur les variations de la Pbal. 3.Déterminer l'impact de la régulation continue de la Pbal sur la survenue de complications liées à l'intubation sur un modèle animal d'abord puis chez le patient de réanimation. Incidence et facteurs de risque Tout d'abord nous avons réalisé une étude prospective observationnelle sur une cohorte de 101 patients intubés et ventilés afin de déterminer l'incidence des souspressions et surpressions du ballonnet et de déterminer leurs facteurs de risque. La Pbal a été ajustée manuellement toutes les 8h. Les Pbal et pressions des voies aériennes ont été enregistrées en continu sur 8h. Seuls 18% des patients avaient une Pbal constamment normale (20-30 cmH2O). 54% des patients ont présenté des souspressions, 73% des surpressions. De plus, 33% des patients ont présenté une souspression ou une surpression >30 minutes. Les facteurs de risque indépendamment associés à la survenue de souspressions étaient la durée d'intubation (OR=1,1(ICà95 %)1-1,2, p=0,039) et l'absence de sédation (2,5(1-6), p<0,01). Nous n'avons pas pu identifier de facteurs de risques de surpressions. 2.Impact du matériau et de la forme du ballonnet Nous avons réalisé ensuite une autre étude prospective observationnelle afin de déterminer l'impact du polyuréthane (PU) et de la forme du ballonnet sur les variations de la Pbal. 76 patients intubés et ventilés (26 ballonnets en PVC, 22 ballonnets en PU de forme cylindrique [Cy] et 28 ballonnets en PU de forme conique [Co]) ont été inclus. La Pbal a été ajustée manuellement toutes les 8h. Les Pbal et pressions des voies aériennes ont été enregistrées en continu sur 24h. Aucune différence significative n'a été retrouvée entre les 3 groupes quant au pourcentage du temps passé avec une souspression du ballonnet (moy±SD 26±22, 28±12, 30±13% dans les groupes PVC, PUCy et PUCo; respectivement) ou au pourcentage du temps passé avec une surpression (med[25è-75è centiles] 7[2-14], 6[3-14], 11%[5-20]). 3.Impact de la régulation continue de la Pbal sur la survenue de complications *Etude animale Il s'agit d'une étude randomisée contrôlée portant sur 12 porcs intubés et ventilés pendant 48h. L'objectif principal était de déterminer l'impact de la régulation continue de la Pbal sur les lésions ischémiques trachéales.
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Zimmerman, Angela D. "Nursing interventions in the care of patients undergoing induced hypothermia." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/531.

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Use of induced hypothermia for the purpose of lowering intracranial pressure and preserving neuronal function has increased as research data reveals a trend of positive outcomes in patients treated with this therapy. Recently induced hypothermia following cardiac arrest due to ventricular fibrillation has been deemed successful. Current research has expanded to evaluate the effectiveness of induced hypothermia as a treatment modality for severe stroke and head trauma. In spite of its efficacy, complications exist with this treatment modality. The purpose of this literature review is to examine potential complications secondary to induced hypothermia and highlight the nurse's role in managing patient care. At the present, patient protocols for induced hypothermia are lacking. The success of treatment is largely dependent on the skill of the healthcare team to prevent further harm and enhance therapeutic outcomes by providing astute assessment and management of complications in patients undergoing induced hypothermia. The desired outcome of this review is to promote integration of research in the development of evidence-based protocols for induced hypothermia.<br>B.S.N.<br>Bachelors<br>Nursing<br>Nursing
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Judas, Gustavo Ieno. "Efeito da injeção intratecal de células tronco do cordão umbilical humano na lesão isquêmica da medula espinhal em ratos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-04022014-120855/.

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INTRODUÇÃO: A isquemia da medula espinhal continua sendo uma importante complicação nas cirurgias das doenças da aorta descendente torácica e toracoabdominal. OBJETIVOS: Células-tronco são capazes de promover a regeneração do tecido nervoso. Células-tronco derivadas do cordão umbilical humano (CTCUH) são fortes candidatas para uso nas lesões da medula espinhal devido à sua baixa imunogenicidade e pronta disponibilidade. O estudo avaliou os efeitos da administração de CTCUH na lesão isquêmica da medula espinhal em ratos. MÉTODOS: Quarenta ratos Wistar receberam injeção intratecal de 10 uL de solução de HemoHes (6 %) e albumina humana (20 %) contendo 1x104 CTCUH, 30 minutos antes (grupo Tcpré; n=10) e 30 minutos após (grupo Tcpós n=10) oclusão da aorta torácica descendente através de um balão intraluminal por 12 minutos. Os grupos controle receberam apenas a solução de Hemohes (6 %) e albumina humana (20 %) (grupo Cpré; n=10 e grupo Cpós; n=10). O período observacional, para avaliação da função motora dos animais, foi de 28 dias. Cortes de três segmentos tóraco-lombares da medula espinhal foram submetidos à análise histológica e imunohistoquímica para detecção de apoptose (TUNEL) e quantificação de células-tronco humanas hematopoiéticas CD45 +. RESULTADOS: Todos os grupos mostraram incidência semelhante de paraplegia e mortalidade. A média de pontuação da função motora não mostrou diferença durante o período observacional nos grupos, com exceção do grupo Tcpós o qual melhorou de 8,14 ± 8,6 para 14,28 ± 9,8 (p < 0,01). Número de neurônios viáveis foi maior no grupo Tcpós (p=0,14) e a média de apoptose foi mais baixa nesse mesmo grupo (p=0,048), porém sem diferença estatística significativa em relação ao controle. Foi confirmada a presença de células CD45 + quatro semanas após a injeção intratecal em ambos os grupos terapêuticos, principalmente, no grupo Tcpós. CONCLUSÕES: A injeção intratecal de CTCUH é factível e melhora a função motora da medula espinhal em um modelo de oclusão endovascular da aorta torácica descendente<br>BACKGROUND: Spinal cord ischemia remains a complication after surgical repair of descending and thoracoabdominal aortic diseases. OBJECTIVES: Stem cells have the potential to induce nervous tissue regeneration processes. Human stem cells derived from the umbilical cord are one of strong candidates used in cell therapy for spinal cord injury due to weak immunogenicity and ready availability. We sought to evaluate the use of Human Umbilical Cord Blood Stem Cells (HUCBSC) attenuates the neurologic effects of spinal cord ischemia. METHODS: Fourty Wistar rats received intrathecally injection of 10 uL Hemohes (6 %) and human albumin (20 %) solution contained 1x104HUCBSC, 30 minutes before (Tcpré group; n=10) and 30 minutes after (Tcpós group; n=10) descending thoracic aortic occlusion by intraluminal balloon during 12 minutes. Control groups received only PBS solution (Cpré group; n=10 and Cpós group; n=10). During a 28-day observational period, animals motor function was assessed. Three segments of thoraco-lombar spinal cord specimens were analyzed for histologic and immunohistochemical assessment for detection and quantification of human hematopoietic cells CD45+ and apoptosis (TUNEL). RESULTS: All groups showed similar incidence of paraplegia and mortality. The mean motor function scores showed no difference during time, excepting for Tpos group which improved from 8.14(8.6) to 14.28(9.8)(p < 0,01). Number of viable neurons was higher in Tcpós group (p = 0.14) and apoptosis average was lower in the same animals (p = 0.048), but showed no difference with its respective control. We confirmed the presence of CD45+ cells four weeks after intrathecal injection in both therapeutic groups but mainly in Tpos group. CONCLUSIONS: Intrathecal transplantation of HUCBSC is feasible and improved spinal cord function in a model of endovascular descending aortic occlusion
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Cavalcante, Leonardo Pessoa. "Efeito da administração aguda de 17beta-estradiol ou de progesterona em modelo de isquemia-reperfusão medular em ratos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-06022017-103854/.

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INTRODUÇÃO: A lesão medular isquêmica continua sendo uma complicação devastadora das intervenções cirúrgicas na aorta torácica descendente e aorta toracoabdominal. Relatos das diferenças de desfechos clínicos neurológicos entre os gêneros após lesões cerebrais isquêmicas e traumáticas têm levantado o interesse nas influências hormonais, bem como gerado outros estudos buscando a comprovação dos efeitos neuroprotetores do estradiol e da progesterona. Nossa hipótese foi a de que a administração aguda de 17beta-estradiol ou de progesterona seria capaz de prevenir ou atenuar a lesão medular isquêmica causada pela oclusão transitória da aorta torácica descendente proximal. OBJETIVO: Analisar os efeitos na medula espinhal da administração aguda de 17?-estradiol ou de progesterona em modelo experimental de isquemia-reperfusão medular por oclusão transitória da aorta torácica descente proximal de ratos machos. MÉTODOS: Ratos machos, da linhagem wistar, foram divididos aleatoriamente em 3 grupos para a administração de 280ug/Kg de 17beta-estradiol (n=12) ou de 4mg/Kg de progesterona (n=8) ou do veículo de infusão (grupo controle) (n=12), 30 minutos antes da oclusão transitória da aorta torácica descendente por 12 minutos. A confirmação da oclusão efetiva aórtica deu-se por meio da monitorização contínua da pressão arterial média distal com o uso de cateter colocado na artéria caudal dos animais (mantida em 10mmHg). A oclusão da aorta torácica descendente deu-se por meio do posicionamento de um cateter de Fogarty no. 2, passado no sentido caudal, via dissecção da artéria carótida comum esquerda do animal. A função locomotora dos animais foi avaliada no 1o, 3o, 5o, 7o, e 14o dia pós-operatório. No 14o dia pós-operatório, os animais, após anestesia profunda, foram sacrificados e tiveram suas medulas espinhais retiradas para análise histológica e imunohistoquímica. RESULTADOS: Houve comprometimento significativo da função locomotora inicialmente nos 3 grupos de estudo, com recuperação parcial da mesma ao longo do período de observação, não havendo diferença entre os grupos durante o período de observação. A análise histológica da substância cinzenta evidenciou escassos neurônios viáveis e importante vacuolização celular nos 3 grupos de estudo no 14o dia. A análise imunohistoquímica da substância cinzenta medular com anticorpos anti-Bcl2 e anti-anexina V foi similar nos 3 grupos. Houve marcação positiva de necrose celular com o iodeto de propídio, sendo a mesma semelhante nos 3 grupos estudados. CONCLUSÃO: A administração aguda de estradiol ou de progesterona, 30 minutos antes da oclusão transitória da aorta descendente proximal de ratos machos não foi capaz de prevenir ou atenuar a lesão medular isquêmica, até o 14o dia de observação, do ponto vista funcional ou histológico<br>BACKGROUND: Spinal cord ischemic injury remains a dreadful complication following thoracic and thoracoabdominal aortic interventions. Reports on gender-related neurological outcomes after ischemic and traumatic brain injuries have raised interest in hormonal influences, and have generated studies into neuroprotective effects of estrogen and progesterone. We hypothesized that the acute pre-operative administration of estradiol or of progesterone would prevent or attenuate spinal cord ischemic injury induced by transitory occlusion of the proximal descending thoracic aorta. OBJECTIVE: Evaluate the spinal cord effects of the acute administration of 17beta-estradiol or of progesterone in a spinal cord ischemia-reperfusion model. METHODS: Male rats were divided to receive 280ug/Kg of 17beta-estradiol (n=12) or 4mg/Kg of progesterone (n=8) or vehicle (control group) (n=12) 30 minutes before transitory occlusion of the proximal descending thoracic aorta, mean distal arterial blood pressure was maintained at 10mmHg during 12 minutes. Hind limb motor function was assessed at 1, 3, 5, 7 and 14 days after reperfusion. At the 14th day, a segment of the thoracolumbar spinal cord was harvested and prepared to histological and imunohistochemical analyses. RESULTS: There was an important hind limb motor function impairment initially in the 3 study groups, with partial improvement along time, but no difference was detected between groups during de observational period. Gray matter analysis showed scarce viable neurons and a marked cellular vacuolation in all three groups, but the number of viable neurons per section areas was not different between study groups at day 14th. Immunostaining of the spinal cord gray matter with antibodies anti-Bcl2 and anti-annexin V was similar among the 3 study groups. There was positive staining for the necrotic marker propidium iodide, with all groups presenting a similar staining pattern. CONCLUSION: We found that a single-dose administration of estradiol or of progesterone, 30 minutes before transitory occlusion of the proximal descending thoracic aorta of male rats, was not able to prevent spinal cord ischemic injury through analysis of functional and histological outcomes at 14 days of observation
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Surugue, Georges Auguste Bourreli Bernard. "Complications ischémiques myocardiques après administration de sulprostone dans les hémorragies du post-partum." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=45656.

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Pundik, Svetlana. "EFFECT OF OLDER AGE ON THE RISK OF HEMORRHAGIC COMPLICATIONS AFTER INTRAVENOUS AND/OR INTRA-ARTERIAL THROMBOLYSIS FOR ACUTE ISCHEMIC STROKE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207236995.

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Grigis, de Lagoutine Irène. "Les ischémies aiguës graves dans l'association endocardite infectieuse et thrombocytémie essentielle : à propos d'un cas." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2M166.

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Books on the topic "Ischemia – Complications"

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Napoli, Mario Di. Neuroinflammation: An important role in the pathogenic pathways of cerebral ischemia. Nova Science Publishers, 2008.

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Shioshvili, Tamaz J. Kidney transplantation: Denervation, reinnervation, ischemia, hypothermia. Nova Science, 2009.

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Smith, T. C. G. 1939-, ed. Ischaemia in head injury: 10th European Congress of Neurosurgery, Berlin 1995 ; proceedings of a special symposium. Springer, 1996.

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Johannes, Janse Michiel, ed. The ventricular arrhythmias of ischemia and infarction: Electrophysiological mechanisms. Futura Pub. Co., 1993.

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1938-, Rosen Michael R., and Palti Yoram, eds. Lethal arrhythmias resulting from myocardial ischemia and infarction: [proceedings of the Second Rappaport Symposium]. Kluwer Academic Publishers, 1989.

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Steinau, Hans-Ulrich. Major limb replantation and postischemia syndrome: Investigation of acute ischemia-induced myopathy and reperfusion injury. Springer-Verlag, 1987.

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Hayreh, Sohan Singh. Ischemic optic neuropathies. Springer, 2011.

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A, Baethmann, Go K. G, and Unterberg A, eds. Mechanisms of secondary brain damage. Plenum Press, 1986.

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Zoppo, Gregory J. Del. Innate inflammation and stroke. Edited by New York Academy of Sciences. Published by Blackwell Pub. on behalf of the New York Academy of Sciences, 2010.

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D, Silver Malcolm, ed. Sudden death in ischemic heart disease: An alternative view on the significance of morphologic findings. Springer-Verlag, 1995.

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Book chapters on the topic "Ischemia – Complications"

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Caranci, Ferdinando, Enrico Tedeschi, and Arturo Brunetti. "Early Complications: Perilesional Ischemia." In Imaging Gliomas After Treatment. Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2370-3_15.

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Beyer, D., Ch Kaiser, M. Kress, and S. Horsch. "Complications during and after percutaneous transluminal angioplasty (PTA) of iliac and peripheral arteries." In Critical Limb Ischemia. Steinkopff, 1995. http://dx.doi.org/10.1007/978-3-642-72515-9_10.

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Ricke, Simone, B. Oehm, K. Heye, S. Horsch, and D. Beyer. "Vascular surgical interventions required after complications caused by percutaneous transluminal angioplasty PTA." In Critical Limb Ischemia Carotid Surgery. Steinkopff, 1998. http://dx.doi.org/10.1007/978-3-642-53788-2_5.

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Beyer, Dieter, Ch Kaiser, M. Kress, and S. Horsch. "Complications during and after percutaneous transluminal angioplasty (PTA) of iliac and peripheral arteries." In Critical Limb Ischemia Carotid Surgery. Steinkopff, 1998. http://dx.doi.org/10.1007/978-3-642-53788-2_4.

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Isgro, Frank, Ch Schmidt, G. Grimm, and W. Saggau. "Cerebral ischemia and brain related complications after cardiac surgery." In Cerebral Protection in Cerebrovascular and Aortic Surgery. Steinkopff, 1997. http://dx.doi.org/10.1007/978-3-642-95987-5_20.

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Cuesta, Miguel A., and Donald L. van der Peet. "Case on Small Bowel Ischemia During Neoadjuvant Chemotherapy for Gastroesophageal Junction Cancer." In Case Studies of Postoperative Complications after Digestive Surgery. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01613-9_64.

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Caranci, Ferdinando, Enrico Tedeschi, and Arturo Brunetti. "Early Complications: Perilesional Ischemia—Postoperative MR Follow-Up in Glioblastoma Multiforme." In Imaging Gliomas After Treatment. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31210-7_17.

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de Bruin, Jorg. "Case on Ischemia–Necrosis of the Sigmoid After Repair of a Ruptured Juxtarenal Aneurysm." In Case Studies of Postoperative Complications after Digestive Surgery. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01613-9_85.

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Zafar, Atif, and Enrique C. Leira. "Post-discharge Complications of Stroke." In Ischemic Stroke Therapeutics. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-17750-2_7.

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Aysenne, Aimee M., and S. Andrew Josephson. "Supportive Care and Management of Inhospital Complications." In Ischemic Stroke Therapeutics. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-17750-2_6.

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Conference papers on the topic "Ischemia – Complications"

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Киреева, Виктория, Viktoriya Kireeva, Ю. Усольцев, et al. "Intermediate results 2016 of a search study of translational diagnostic methods Mitochondrial dysfunction in patients with chronic myocardial ischemia and/or head Brain." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec94893.

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Purpose of the study. To rate prognostic properties of changes in mitochondrial DNA concentration in the blood plasma of patients with chronic cerebral ischemia and ischemic heart disease in relation to the disease and the effectiveness of the therapy. Materials and methods. The study involved patients suffering from coronary heart disease (CHD) and chronic cerebral ischemia (CCI) with stable and unstable atherosclerotic plaques, who have signed informed consent to the data processing within the framework of scientific research. The patients were admitted to the hospital for examination and treatment of CHD and CCI in Cardiology and Neurology Unit of the Hospital of ISC SB RAS. The subjects underwent laboratory and instrumental examination and analysis of the level of free circulating serum mitochondrial DNA by real-time PCR (copies/ml). The examination results considered as satisfactory were compared with the mtDNA levels before and after the treatment. Results. The average value of the mtDNA levels before and after the treatment in patients of neurological and cardiological profile were significantly different: 1 093 686 copies/ml vs 418 046 copies/ml, respectively (p = 0.02). Unlike women, men mtDNA levels statistically significantly (p = 0.03) decreased after the treatment. We revealed statistically significant differences in mtDNA level indicators before and after the treatment, depending on the definition of the series (p = 0.0010) for rank test Kruskal – Wallis test. The results of the proposed research will help to identify prognostic factors of destabilization of cell damage and plaques in endothelial dysfunction, atherosclerosis and its complications, to conduct clinical test of the method for predicting and diagnostics of cellular damage in chronic ischemia on a background of atherosclerosis.
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Loerakker, Sandra, Anke Stekelenburg, Gustav J. Strijkers, et al. "Effect of Continuous and Intermittent Mechanical Loading on the Development of Skeletal Muscle Damage - A Combined Experimental/Numerical Approach." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206354.

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Prolonged mechanical loading of soft tissues, as present when individuals are bedridden or wheelchair-bound, can lead to degeneration of skeletal muscle tissue. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, e.g. skeletal muscle, near bony prominences and progresses towards the skin. Complications associated with DTI include sepsis, renal failure, and myocardial infarction. Damage pathways leading to DTI involve ischemia, ischemia-reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, the role of tissue deformation in the onset of skeletal muscle damage was established by combining animal experiments with finite element (FE) modeling [1]. After 2 hours of continuous loading, a clear correlation between maximum shear strain and damage was found.
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Attaluri, Anilchandra, Liang Zhu, and Zhongping Huang. "Targeted Brain Hypothermia Induced by an Interstitial Cooling Device in Human Neck: An Experimental Study." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205558.

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In recent years, mild or moderate hypothermia during which brain temperature is reduced to 30–35°C, has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia during cardiac bypass injury [Nussmeier 2002], carotid endarterectomy [Jamieson et al., 2003] and resection of extra-cranial aneurysm [Wagner and Zuccarello 2005], as well as stroke and traumatic brain injury [Marion et al., 1996; Marion 1997]. It has been shown that a reduction in brain temperature as small as 2°C substantially reduced ischemic cell damage [Clark et al., 1996], or improved significantly post-ischemic regional histopathology [Wass et al., 1995]. Most of the currently used clinical studies have examined only systemic hypothermia by whole body cooling. The major methodological drawback of this approach is slow cooling rate (∼0.5°/hour) due to the large volume of the human body and arteriovenous shunt vasoconstriction [Krieger et al., 2001; Marion et al., 1997; Schwab et al., 1998]. Whole body cooling does induce systemic complications. The systemic risks may outweigh the beneficial effects of neuro-hypothermia in the current clinical practice. Selective brain cooling which keeps the rest of body at normal temperature, on the other hand, can be used to maximize the neuroprotection of hypothermia.
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Boire, Timothy, Mukesh Gupta, Brendan Lynch, and Hak-Joon Sung. "Development of a Shape Memory Patch for Vascular Injuries." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14710.

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There is a high risk of surgical complications when treating vascular injuries such as ruptures and ischemia associated with strokes, aneurysms, and other vascular diseases. Moreover, it is still challenging to repair injuries of small diameter blood vessels through currently available therapeutic approaches because of limited access and small path length. To address these issues, a vascular patch made of biodegradable shape memory polymers (SMPs) can be deployed to the injured or ruptured site in a minimally invasive manner via a catheter or laparoscope, as shown in Figure 1. SMPs are capable of achieving minimally-invasive implantation and repair vascular injuries because they can be fixed into a temporary shape (i.e. an injectable shape for placement through a laparoscope) and recover their original, permanent shape (i.e. a ruptured tissue-specific shape) when triggered by an external stimulus such as heating above its melting temperature (T m).
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Teddy Weiss, A., David G. Fine, David Applebaum, et al. "PREHOSPITAL CORONARY THROMBOLYSIS: A NEW STRATEGY IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642979.

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Thirty-four patients with acute myocardial infarction were treated prospectively using a new strategy of pre-hospital intravenous streptokinase given by a physician-operated mobile intensive care unit. Prehospital treated patients who had experienced no previous myocardial infarction were compared to a similar group treated with streptokinase in-hospital. All patients underwent cardiac catheterization on day 6.Patients receiving streptokinase in the pre-hospital phase of acute myocardial infarction had smaller infarcts and better residual myocardial function than the group given streptokinase in-hospital in terms of peak creatine phosphokinase (900 v.1298 IU, p=0.023), ejection fraction (62 v. 55%, p=0,004), computer-derived dysfunction index (427 v. 727, p=0.003), and electrocardiographic QRS score (4.1 v. 6.4, p=0.001). The only difference between these groups at baseline was the duration of pain prior to initiation of streptokinase therapy (1.0 ± 0.4 hours vs. 1.9 ± 0.9 hours). There were no major complications related to pre-hospital administration of streptokinase.Pre-hospital stretokinase infusion is feasible, safe and practical. It reduces ischemia time because treatment is not delayed until hospital arrival and therapy limits infarct size. Thrombolytic therapy for acute myocardial infarction can be initiated at home and should not be limited to hospitalized patients.
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Fayssal, Iyad, Fadl Moukalled, Samir Alam, Robert Habib, and Hussain Ismaeel. "The Development of a Robust Low Computational Cost Diagnostic Tool to Evaluate Stenosis Functional Significance in Human Coronary Arteries." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51532.

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There is discordance between the anatomic severities of the coronary narrowing and their corresponding functional significance. Fractional Flow Reserve (FFR) is among the physiological parameters invasively measured to assess the hemodynamic significance of a stenosis during maximal hyperemia. FFR values ≤ 0.8 indicate that the downstream heart tissue perfused by this vessel is at risk for ischemia. While measuring FFR is an invasive procedure that is expensive, time consuming, and not without complications, recently, noninvasive estimation of FFR was shown to be possible from comprehensive predictive techniques allowing the computation of in-vivo FFR. However, these non-invasive methods are associated with high computational cost and require high performance computing technology, thus, reducing their wide adoption in clinics. This paper is steered to achieve two main goals: (1) to develop a fast numerical method to aid clinicians assessing ischemia level and determine if coronary revascularization (PCI) is required in human diseased coronary arteries with minimum time and computer resources; (2) to develop a robust method which allows predicting the patient FFR independently of the actual in-vivo physiologic conditions (mainly pressure) of the specific patient. The numerical framework was designed by adopting the finite volume method to generate the discrete model of the Reynolds average form of conservation equations used to predict blood hemodynamics. Two strategies were investigated to reduce computational cost while retaining solution accuracy. The first strategy is based on isolating the diseased artery from its branch tree and simulating it separately without implicitly integrating other arterial segments. A lumped dynamic model with special numerical treatment is coupled to the 3D domain outlet boundary to account for the downstream effects from the vascular bed. The second strategy is based on replacing a full transient simulation by a steady state one performed under mean conditions of pressure and blood volume flow rate. The strategy was applied on a healthy (hypothetical) and stenosed arterial segments with different stenosis severities simulated under rest and hyperemic conditions. An excellent agreement was achieved for FFR values computed from full transient simulations with the ones obtained from steady state simulation (error &lt; 0.2 % was obtained for all test cases). The computational cost for the mean condition scenario was 0.1 that of a full transient simulation. The robustness of the method was tested by varying inflow conditions and reporting their effect on FFR. Interestingly, the predicted ischemia level was not altered when the inlet pressure was increased by 10 % from the base case. An analytical model was derived to explain the FFR independency of patient in-vivo coronary pressure. These promising findings from the numerical tests performed on idealized healthy and stenosed arterial models could significantly impact the applicability of the developed methodology and translating it into future practical clinical applications.
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Septiani, Anissa Eka, Bhisma Murti, Setyo Sri Rahardjo, and Hanung Prasetya. "Meta-Anaylsis: Gender and the Risk of Lower Extremity Amputation in Patients with Type 2 Diabetes Mellitus and Foot Ulcer." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.37.

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ABSTRACT Background: Diabetes is an independent predictor of limb amputation (versus revascularization) for the treatment of critical limb ischemia. Much of the cost related to diabetes results from macrovascular and microvascular complications, such as myocardial infarctions, end-stage renal disease, and lower extremity amputations (LEAs). This study aimed to examine the associations between gender and the risk of lower extremity amputation in patients with type 2 diabetes mellitus and foot ulcer. Subjects and Method: A meta-analysis and systematic review was conducted by collected published articles from Pubmed, Scopus, Google Scholar, and Springer Link databases. Lower limb amputation, lower extremity amputation, diabetic foot, and diabetic ulcer keywords were used to collect the articles. The inclusion criteria were full text, cohort study, and reporting adjusted odds ratio. The selected articles were analyzed by PRISMA flow chart and revman 5.3. Results: 9 articles were reported that male increased the risk of lower extremity amputation in type 2 DM patients (aOR= 1.60; 95% CI= 1.32 to 1.94; p&lt;0.001). Conclusion: Male increases the risk of lower extremity amputation in type 2 DM patients. Keywords: lower extremity amputation, type 2 diabetes mellitus, foot ulcer Correspondence: Anissa Eka Septiani. Masters Program in Public Heath, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: sanissaeka@gmail.com. Mobile: 089514646458. DOI: https://doi.org/10.26911/the7thicph.01.37
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Zhu, Liang, and Chenguang Diao. "Computer-Aided Analysis of Transient and Steady State Temperature Distribution in Human Brain During Selective Cooling of Head Surface and Rewarming for Head Injury Patients." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33686.

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In recent years, mild or moderate hypothermia during which brain temperature is reduced to 30–35°C has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia and traumatic brain injury. There are two approaches for achieving a reduction in brain temperature. One is via systemic hypothermia where the whole body is cooled. This approach may produce deleterious systemic complications and require intensive monitoring. Another approach is called selective brain cooling (SBC) in which the brain is selectively cooled while the rest of the body is kept at normal temperature. Clinically feasible SBC protocols include head hood or helmet with water or chemical cooling, head immersion in iced water, nasophyaryngeal cooling after tracheal intubation, and intro-carotid flushing. Simply packing ice or wearing cooling helmet is easy to implement. Previous theoretical study [Zhu and Diao, 2001] suggests that it is feasible to achieve mild hypothermia via head surface cooling. However, most physicians believe that it takes a much longer time to reduce the brain temperature using head surface cooling. In this study, a three-dimensional theoretical model is developed to study the transient and steady state temperature distribution in the brain during SBC. The effect of regionally varying local blood perfusion rate in the brain tissue on the temporal and spatial temperature gradient is examined. Other factors including the brain size and the thermal contact resistance between the cooling medium and the head scalp are evaluated in the simulation.
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Nangrani, K., A. Kumari, and J. Zeibeq. "Unilateral Testicle Ischemia as a Complication of Extending Abdominal Aortic Dissection." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2926.

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Gao, Bo, and Zhaoming He. "Coaptation Mechanism of Dilated Mitral Valves." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19601.

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Abstract:
Functional mitral regurgitation, which occurs as a consequence of regional of global left ventricular or global left ventricular dysfunction despite structurally normal mitral valve (MV), is a common complication in patients with ischemic or non-ischemic cardiomyopathies [1].
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