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Journal articles on the topic 'Ischemic stroke'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Kern, Ralph Z. "Progress in Clinical Neurosciences: Migraine-Stroke: A Causal Relationship, but Which Direction?" Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 31, no. 4 (2004): 451–59. http://dx.doi.org/10.1017/s0317167100003620.

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A significant association between migraine and ischemic stroke has been demonstrated in population and case-control studies. The risk of ischemic stroke appears to be higher in migraine with aura (MWA) than migraine without aura (MwoA). Migraine-stroke comprises a number of distinct entities, including migrainous infarction, in which ischemic stroke occurs during an attack of MWA and migraine-related stroke, in which the causal link is less clear. Migrainous infarction accounts for only one-third of migraine-stroke, strokes may occur during attacks of MwoA, and a number of cerebrovascular diso

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Pan, Jingrui, Xiangpen Li, and Ying Peng. "Remote ischemic conditioning for acute ischemic stroke: dawn in the darkness." Reviews in the Neurosciences 27, no. 5 (2016): 501–10. http://dx.doi.org/10.1515/revneuro-2015-0043.

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AbstractStroke is a leading cause of disability with high morbidity and mortality worldwide. Of all strokes, 87% are ischemic. The only approved treatments for acute ischemic stroke are intravenous thrombolysis with alteplase within 4.5 h and thrombectomy within 8 h after symptom onset, which can be applied to just a few patients. During the past decades, ischemic preconditioning has been widely studied to confirm its neuroprotection against subsequent ischemia/reperfusion injury in the brain, including preconditioning in situ or in a remote organ (such as a limb) before onset of brain ischemi

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3

Boling, Bryan, and Katie Keinath. "Acute Ischemic Stroke." AACN Advanced Critical Care 29, no. 2 (2018): 152–62. http://dx.doi.org/10.4037/aacnacc2018483.

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Acute ischemic stroke is a major cause of mortality and morbidity in the United States and worldwide. Despite the development of specialized stroke centers, mortality and morbidity as a result of acute ischemic strokes can and do happen anywhere. These strokes are emergency situations requiring immediate intervention. This article covers the fundamentals of care involved in treating patients with acute ischemic stroke, including essentials for the initial evaluation, basic neuroimaging, reperfusion therapies, critical care management, and palliative care, as well as current controversies. Nati

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Brinjikji, Waleed, Jonathan M. Morris, Robert D. Brown, et al. "Neuroimaging Findings in Cardiac Myxoma Patients: A Single-Center Case Series of 47 Patients." Cerebrovascular Diseases 40, no. 1-2 (2015): 35–44. http://dx.doi.org/10.1159/000381833.

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Background and Purpose: Cardiac myxomas can present with a myriad of neurological complications including stroke, cerebral aneurysm formation and metastatic disease. Our study had two objectives: (1) to describe the neuroimaging findings of patients with cardiac myxomas and (2) to examine the relationship between a history of embolic complications secondary to myxoma and intracranial aneurysm formation, hemorrhage and metastatic disease. We hypothesized that patients who present with embolic complications related to myxoma would be more likely to have such complications. Materials and Methods:

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Khodjaeva, N. A. "PREVALENCE OF ISCHEMIC STROKE IN BUKHARA REGION." Oriental Journal of Medicine and Pharmacology 02, no. 01 (2022): 168–75. http://dx.doi.org/10.37547/supsci-ojmp-02-01-13.

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We analyzed the frequency of occurrence of various types of strokes and studied data on the epidemiology of ischemic stroke subtypes using the example of one neurological department. The most common was the atherothrombotic type of ischemic stroke, the least common was the hemodynamic type. The highest risk of ischemic stroke of various types are people with hypertension, tobacco users and overweight, the likelihood of ischemic stroke is higher in autumn and spring.

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Simats, Alba, Laura Ramiro, Teresa García-Berrocoso, et al. "A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke." Molecular & Cellular Proteomics 19, no. 12 (2020): 1921–35. http://dx.doi.org/10.1074/mcp.ra120.002283.

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Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke diagnosis, prognosis, and treatment. Data integration from high-throughput -omics techniques has become crucial to unraveling key interactions among different molecular elements in complex biological contexts, such as ischemic stroke. Thus, we used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics

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Nawab, Kalsoom, Anwar Ul Haq, Mehmood Akhtar Khattak, Hina Gul, Naheed Khan, and Irsa Shoaib. "A Systematic Review of Magnetic Resonance Imaging for the Diagnosis of Stroke." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 764–65. http://dx.doi.org/10.53350/pjmhs2023173764.

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Background: With the advancement of magnetic resonance imaging (MRI), a non-invasive imaging technique, ischemic and hemorrhagic stroke diagnostic accuracy has increased significantly. The intricate resolution of MRI enables better visualisation of the structure of the brain and vulnerable regions to ischemia. As a result, the detection of hypoperfused areas is now more accurate. Additionally, MRI makes it possible to see hematomas in the brain, revealing hemorrhagic strokes brought on by burst arteries. MRI has become an essential tool in the fight against strokes because to its crucial role

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Babirad, A. M. "ATTITUDES TOWARDS DISEASE IN PATIENTS WITH CHRONIC PHASE OF ISCHEMIC STROKE BY THE RESULTS OF THE PERSONAL QUESTIONNAIRE OF THE BEKHTEREV INSTITUTE." East European Journal of Parkinson`s Disease and Movement Disorders 6, no. 3-4 (2020): 19–26. http://dx.doi.org/10.33444/2414-0007.6.3-4.19-26.

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Every year, strokes are diagnosed in about 16 million people, of whom 5.7 million die and about the same number become disabled (Feigin V.L., Forouzanfar M.H., Krishnamurthi R., et al., 2014; Virani S.S., Alonso A., Benjamin E.J., et al., 2020; Kim J., Thayabaranathan T., Donnan G.A., et al. 2020). The objective of our research was to study the attitudes towards disease in patients with chronic phase of ischemic stroke. Material and methods. 100 consecutive patients with chronic phase of ischemic stroke and 17 patients with chronic cerebral ischemia were questioned in neurology in-patient depa

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Al-Mufti, Fawaz, Krishna Amuluru, William Roth, Rolla Nuoman, Mohammad El-Ghanem, and Philip M. Meyers. "Cerebral Ischemic Reperfusion Injury Following Recanalization of Large Vessel Occlusions." Neurosurgery 82, no. 6 (2017): 781–89. http://dx.doi.org/10.1093/neuros/nyx341.

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Abstract Although stroke has recently dropped to become the nation's fifth leading cause of mortality, it remains the top leading cause of morbidity and disability in the US. Recent advances in stroke treatment, including intravenous fibrinolysis and mechanical thromboembolectomy, allow treatment of a greater proportion of stroke patients than ever before. While intra-arterial fibrinolysis with recombinant tissue plasminogen is an effective for treatment of a broad range of acute ischemic strokes, endovascular mechanical thromboembolectomy procedures treat severe strokes due to large artery oc

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Berthet, Carole, Lijing Xin, Lara Buscemi, et al. "Non-Invasive Diagnostic Biomarkers for Estimating the Onset Time of Permanent Cerebral Ischemia." Journal of Cerebral Blood Flow & Metabolism 34, no. 11 (2014): 1848–55. http://dx.doi.org/10.1038/jcbfm.2014.155.

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The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ∼ 30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brains might allow the precise estimation of cerebral ischemia onset time. We modeled ischemic stroke in male ICR-CD1 mice using a permanent middle cerebral artery filament occlusion model with laser Doppler control of the regional cerebral blood flow. Mice were then subjected to repeated MRS measurements of ipsilateral striatum at 14.1 T. A stri

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Wang, Qianwen, Xu Liu, and Ruixia Zhu. "Long Noncoding RNAs as Diagnostic and Therapeutic Targets for Ischemic Stroke." Current Pharmaceutical Design 25, no. 10 (2019): 1115–21. http://dx.doi.org/10.2174/1381612825666190328112844.

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LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity, which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Altered lncRNA expression has been found in rodent focal cerebral ischemia models and oxygen–glucose deprived mouse brain microvascular endothelial cells as well as stroke patients. LncRNA

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Hasibuan, Hijriyah Putri Tarmizi, and Isra Thristy. "Comparison of Tryglicerides Levels and Total Cholesterol in Ischemic Stroke and Haemorrhagic Stroke Patients." Muhammadiyah Medical Journal 1, no. 2 (2020): 49. http://dx.doi.org/10.24853/mmj.1.2.49-56.

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Background: Stroke is the second largest cause of death in the world. Stroke is classified based on its etiology as ischemic stroke and hemorrhagic stroke. Most large-scale studies on the risk of total cholesterol and triglyceride levels in stroke are not distinguished between ischemic and hemorrhagic strokes. Purposes: The purpose of this study was to determine the comparison of triglyceride and total cholesterol levels in ischemic stroke patients with hemorrhagic stroke. Method: Descriptive analytic study using medical records of patients at Medan Haji General Hospital in 2018-2019. The numb

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Hasibuan, Hijriyah Putri Tarmizi, and Isra Thristy. "Comparison of Tryglicerides Levels and Total Cholesterol in Ischemic Stroke and Haemorrhagic Stroke Patients." Muhammadiyah Medical Journal 1, no. 2 (2020): 7. http://dx.doi.org/10.24853/mmj.1.2.7-14.

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Background: Stroke is the second largest cause of death in the world. Stroke is classified based on its etiology as ischemic stroke and hemorrhagic stroke. Most large-scale studies on the risk of total cholesterol and triglyceride levels in stroke are not distinguished between ischemic and hemorrhagic strokes. Purposes: The purpose of this study was to determine the comparison of triglyceride and total cholesterol levels in ischemic stroke patients with hemorrhagic stroke. Method: Descriptive analytic study using medical records of patients at Medan Haji General Hospital in 2018-2019. The numb

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Shakil, Saate S., Sophia Emmons-Bell, Christine Rutan, et al. "Stroke Among Patients Hospitalized With COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry." Stroke 53, no. 3 (2022): 800–807. http://dx.doi.org/10.1161/strokeaha.121.035270.

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Background and Purpose: Coronavirus disease 2019 (COVID-19) may be associated with increased risk for ischemic stroke. We present prevalence and characteristics of strokes in patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection enrolled in the American Heart Association COVID-19 Cardiovascular Disease Registry. Methods: In this quality improvement registry study, we examined demographic, baseline clinical characteristics, and in-hospital outcomes among hospitalized COVID-19 patients. The primary outcomes were ischemic stroke or transient ischemic attack

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Amalia Amin, Assyifa. "POST ISCHEMIC STROKE IMAGING AND ITS CLINICAL RELEVANCE: A SYSTEMATIC REVIEW." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 9, no. 5 (2023): 45–50. http://dx.doi.org/10.53555/nnmhs.v9i5.1682.

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Stroke is a focal or global functional brain disorder that starts suddenly and lasts longer than 24 hours and is caused by changes in cerebral blood flow. It is not caused by transient cerebral circulatory abnormalities, brain tumors, or secondary strokes as a result of trauma or infection. Strokes can develop in any part of the brain. Ischemia or brain hemorrhage are also potential causes of a stroke that occurs suddenly and leads in neurologic impairments. Strokes are classified into two types: bleeding and non-bleeding. Both are potentially fatal. Several studies have found that imaging is

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Lobzin, V. Yu, and L. G. Nikiforova. "Dopplerographic features of venous cerebral blood flow disorders in acute period of ischemic stroke." Medical alphabet, no. 1 (March 2, 2022): 22–28. http://dx.doi.org/10.33667/2078-5631-2022-1-22-28.

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The article analyzes results of a Doppler study of brachiocephalic vessels in the acute period of ischemic stroke. The role of the venous link of blood flow in maintaining the intracerebral constant in the acute period of ischemic stroke was revealed. The features of the reactivity of cerebral venous hemodynamics in patients with different volumes of brain damage during the formation of ischemic foci of various localization are shown. Attention is paid to the importance of a comprehensive assessment of cerebral venous circulation in the acute period of ischemic stroke. It was shown that in pat

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Ramazanov, G. R., A. N. Trofimova, E. A. Kovaleva та E. V. Shevchenko. "Аortic arch atheroma as a source of arterio-arterial embolism and ischemic stroke". Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) 13, № 2 (2023): 31–39. http://dx.doi.org/10.20340/vmi-rvz.2023.2.clin.1.

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Introduction. Currently, despite the introduction of modern diagnostic algorithms in 20-40 % of patients with ischemic stroke, it is not possible to establish its cause. Potential causes of acute cerebral ischemia in patients with cryptogenic ischemic stroke include paroxysmal atrial fibrillation, patent foramen ovale, atrial cardiomyopathy, carotid network, aortic arch atheroma, and cancer-associated thrombophilia.Target: to systematize data on methods for diagnosing and preventing aortic arch atheroma.Material and methods. The literature search was carried out in electronic search systems Sc

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Lee, Kathy B. "Can the Use of Oral Minocycline Improve Ischemic Stroke Outcomes?" Journal of Pharmacy Practice 21, no. 2 (2008): 159–64. http://dx.doi.org/10.1177/0897190007312310.

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Cerebrovascular accident (CVA), also known as ischemic stroke, is the sudden onset of neurologic deficit attributable to a focal vascular cause.1 It is the third leading cause of death, with the death rate being reported as 50.0 (per 100,000 population) in the United States in 2004.2 It is also a leading cause for serious, long-term disability in the United States. While there are various causes, the large majority of strokes result from either global or focal ischemia of the brain. Ischemic stroke accounts for 87% of all strokes, while intracerebral and subarachnoid hemorrhage makes up the re

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fitria candradewi, susan, and Shinta Dewi Nur Rahmah. "ANALISIS HUBUNGAN TERAPI ANTIHIPERTENSI SEBAGAI PENCEGAHAN SEKUNDER TERHADAP KEJADIAN SERANGAN ULANG STROKE ISKEMIK PADA PASIEN STROKE ISKEMIK." Jurnal Insan Farmasi Indonesia 5, no. 1 (2022): 1–8. http://dx.doi.org/10.36387/jifi.v5i1.923.

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Individuals who survive a first ischemic stroke are at high risk for recurrent stroke. This study aims to analyze the relationship between antihypertensives on the incidence of ischemic stroke recurrence in ischemic stroke patients. Type of research is analytic observational with a retrospective cohort approach. The research sample was taken using purposive sampling technique. The research sample was patients who had an ischemic stroke at PKU Muhammadiyah Hospital Yogyakarta in 2018. There were 201 samples that met the inclusion criteria. Consisting of 135 treatment groups and 66 patients as t

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Kvistad, Christopher Elnan, Vojtech Novotny, Halvor Næss, et al. "Safety and predictors of stroke mimics in The Norwegian Tenecteplase Stroke Trial (NOR-TEST)." International Journal of Stroke 14, no. 5 (2018): 508–16. http://dx.doi.org/10.1177/1747493018790015.

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Background Stroke mimics are frequently treated with thrombolysis in clinical practice and thrombolytic trials. Although alteplase in stroke mimics has proven to be safe, safety of tenecteplase in stroke mimics has not been assessed in an ischemic stroke study setting. We aimed to assess clinical characteristics and safety of stroke mimics treated with thrombolysis in the Norwegian Tenecteplase Stroke Trial. We also aimed to identify possible predictors of stroke mimics as compared to patients with acute cerebral ischemia. Methods Norwegian Tenecteplase Stroke Trial was a phase-3 trial investi

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Somasundaran, Abhilash, Hashik Mohammed, Jayaraj Kezhukatt, Alvin Treasa George, and S. Narayanan Potty. "Accuracy of Siriraj stroke scale in the diagnosis of stroke subtypes among stroke patients." International Journal of Research in Medical Sciences 5, no. 3 (2017): 1084. http://dx.doi.org/10.18203/2320-6012.ijrms20170666.

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Background: Early detection of intracranial blood is essential for the rational use of anti hemostatic drugs in stroke patients. CT scan is quite expensive as well as it is not easily available especially in the rural areas. Clinical stroke scores were developed to overcome these limitations. Aim of present study is to identify the stroke subtype using Siriraj stroke scoring and thus asses its accuracy by comparing with CT scan reports.Methods: A cross sectional study was conducted in a tertiary centre that evaluated 464 patients admitted with a diagnosis of stroke. Siriraj Stroke score was ca

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Halil, Eray. "CT perfusion – an up-to-date element of the contemporary multimodal diagnostic approach to acute ischemic stroke." Folia Medica 65, no. 4 (2023): 531–38. http://dx.doi.org/10.3897/folmed.65.e96954.

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Acute ischemic stroke is of great clinical and societal importance due to its high incidence and mortality rates, as well as the fact that those who are affected suffer from permanent acquired disability. Modern trends explicitly state that the disease’s diagnostic plan should use a multidisciplinary approach. The therapeutic steps that ultimately determine the clinical outcome are defined by an accurate diagnosis of acute ischemic stroke. Highly specialized facilities for the diagnosis and treatment of acute ischemic stroke (Stroke Units) are in operation in countries that make significant in

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Izbassarova, A.S., and A.S. Izbassarova. "THE COURSE OF ISCHEMIC STROKE IN PATIENTS WITH CARDIAC PATHOLOGY IN THE STROKE CENTER OF ALMATY (KAZAKHSTAN)." Deutsche internationale Zeitschrift für zeitgenössische Wissenschaft 43 (November 2, 2022): 21–23. https://doi.org/10.5281/zenodo.7273722.

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In the stroke center of the multidisciplinary clinic in Almaty (Kazakhstan), for the period from 2019 to 2020, 774 patients with a clinical diagnosis of "Acute cerebrovascular accident" were treated. We analyzed 489 medical records of an inpatient with only a diagnosis of "Ischemic stroke"; of these, the average age was 65.5±0.8 years, ischemic stroke predominated in women (1.4 times). We tried to identify the causes of ischemic stroke and found that, in general, of the admitted patients with ischemic stroke, it is (63±2.6%), of which 84.04% fall on the share

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Wu, Cheng-Tien, Ting-Hua Yang, Man-Chih Chen, Siao-Syun Guan, Chang-Mu Chen, and Shing-Hwa Liu. "Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model." Molecules 27, no. 18 (2022): 5783. http://dx.doi.org/10.3390/molecules27185783.

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An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe

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Kauw, Frans, Richard A. P. Takx, Hugo W. A. M. de Jong, Birgitta K. Velthuis, L. Jaap Kappelle, and Jan W. Dankbaar. "Clinical and Imaging Predictors of Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis." Cerebrovascular Diseases 45, no. 5-6 (2018): 279–87. http://dx.doi.org/10.1159/000490422.

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Background: Predictors of recurrent ischemic stroke are less well known in patients with a recent ischemic stroke than in patients with transient ischemic attack (TIA). We identified clinical and radiological factors for predicting recurrent ischemic stroke in patients with recent ischemic stroke. Methods: A systematic search in PubMed, Embase, Cochrane Library, and CINAHL was performed with the terms “ischemic stroke,” “predictors/determinants,” and “recurrence.” Quality assessment of the articles was performed and the level of evidence was graded for the articles included for the meta-analys

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Baule, Antonio. "About ESUS…" AboutOpen 4, no. 1 (2018): 179–84. http://dx.doi.org/10.19156/abtpn.2018.0070.

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Five subtypes of Ischemic stroke are classified based on therir causes. ESUS (Embolic Stroke of Undetermined Source) stands for a non-lacunar cerebral infarct, in the absence of stenosis of large arteries or causes of cardioembolic stroke. It is estimated that ESUS accounts for about 25% of all ischemic strokes. A multidisciplinary, multistep diagnostic investigation is needed for a correct diagnosis, in order to exclude other possible causes of stroke. At present there are limited indications on how to plan secondary prevention of ischemic stroke in patients with ESUS. In the patient describe

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Mandal, SK, M. Majumder, MS Hossain, and M. Sarker. "Serum Ferritin and Plasma Fibrinogen Level in Acute Ischemic Stroke." Bangladesh Journal of Medical Biochemistry 10, no. 1 (2018): 16–20. http://dx.doi.org/10.3329/bjmb.v10i1.36694.

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Acute ischemic stroke is the primary pathology of brain vascular system that temporarily or permanently affects brain functions as a result of ischemia. In ischemic stroke events, many biochemical and immunological reactions occur secondarily in response to the reduced cerebral blood flow. Brain tissue damage after acute ischemic stroke is mediated partly by inflammation induced by ischemia-reperfusion injury. It is thought that acute ischemic stroke due to cerebral ischemia triggers acute phase reaction and the blood concentration of ferritin and fibrinogen could rise during brain infarction.

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Liu, Shimin, Honglian Shi, Wenlan Liu, Takamitsu Furuichi, Graham S. Timmins, and Ke Jian Liu. "Interstitial pO2 in Ischemic Penumbra and Core are Differentially Affected following Transient Focal Cerebral Ischemia in Rats." Journal of Cerebral Blood Flow & Metabolism 24, no. 3 (2004): 343–49. http://dx.doi.org/10.1097/01.wcb.0000110047.43905.01.

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Stroke causes heterogeneous changes in tissue oxygenation, with a region of decreased blood flow, the penumbra, surrounding a severely damaged ischemic core. Treatment of acute ischemic stroke aims to save this penumbra before its irreversible damage by continued ischemia. However, effective treatment remains elusive due to incomplete understanding of processes leading to penumbral death. While oxygenation is central in ischemic neuronal death, it is unclear exactly what actual changes occur in interstitial oxygen tension (pO2) in ischemic regions during stroke, particularly the penumbra. Usin

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Cao, Cathy, Ashley Martinelli, Brian Spoelhof, Rafael H. Llinas, and Elisabeth B. Marsh. "In Potential Stroke Patients on Warfarin, the International Normalized Ratio Predicts Ischemia." Cerebrovascular Diseases Extra 7, no. 2 (2017): 111–19. http://dx.doi.org/10.1159/000478793.

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Background: Stroke can occur in patients on warfarin despite anticoagulation. Patients with a low international normalized ratio (INR) should theoretically be at greater risk for ischemia than those who are therapeutic. Therefore, INR may be able to indicate whether new neurological deficits are more likely strokes or stroke mimics in patients on warfarin. This study evaluates the association and predictive value of INR in determining the likelihood of ischemia. Methods: Patients were identified using the acute stroke registry at a Primary Stroke Center from January 2013 through December 2014.

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Sun, Xiaohui, Tian Wang, Lin Zhou, et al. "How antidepressants affect the cerebral ischemic injury and ischemic stroke." Journal of Pharmaceutical and Biopharmaceutical Research 4, no. 2 (2023): 318–25. http://dx.doi.org/10.25082/jpbr.2022.02.003.

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Ischemic stroke is the main cause of long-term disability and death worldwide. Studies have pointed out that antidepressants not only can be used to treat depression, but also promote nerve regeneration, nerve plasticity, and recovery of nerve function after stroke. Some evidences indicated that antidepressants have beneficial effects on ischemic stroke. At the same time, there are also risks in treatment process. The mechanisms of the effects of antidepressants on ischemic stroke are complicated and rarely reported. This review summarizes the roles of antidepressants in patients and animal mo

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Zhan, Xinhua, Bradley P. Ander, Glen Jickling, et al. "Brief Focal Cerebral Ischemia That Simulates Transient Ischemic Attacks in Humans Regulates Gene Expression in Rat Peripheral Blood." Journal of Cerebral Blood Flow & Metabolism 30, no. 1 (2009): 110–18. http://dx.doi.org/10.1038/jcbfm.2009.189.

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Blood gene expression profiles of very brief (5 and 10 mins) focal ischemia that simulates transient ischemic attacks in humans were compared with ischemic stroke (120 mins focal ischemia), sham, and naïve controls. The number of significantly regulated genes after 5 and 10 mins of cerebral ischemia was 39 and 160, respectively (fold change ⩾∣1.5∣ and P<0.05). There were 103 genes common to brief focal ischemia and ischemic stroke. Ingenuity pathway analysis showed that genes regulated in the 5 mins group were mainly involved in small molecule biochemistry. Genes regulated in the 10 mins gr

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Shahar, Eyal, Lloyd E. Chambless, Wayne D. Rosamond, et al. "Plasma Lipids, Lipoproteins, and Apolipoproteins and Incident Ischemic Stroke:." Circulation 103, suppl_1 (2001): 1363. http://dx.doi.org/10.1161/circ.103.suppl_1.9998-63.

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P63 The role of plasma lipids, lipoproteins, and apolipoproteins in the pathogenesis of ischemic stroke is unclear. We examined the association of incident hospitalized ischemic stroke with baseline plasma measurements of LDL-cholesterol, apoB, HDL-cholesterol, apoA-1, and triglycerides in a population-derived sample of 14,175 middle-aged men and women. Over an average follow up of 8.2 years, we documented 233 incident ischemic strokes (120 in men; 113 in women). After multivariable adjustment for stroke risk factors, categorical analysis revealed weak, inconsistent, and statistically non-sign

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Basu, Elora, Setareh Salehi Omran, Hooman Kamel, and Neal S. Parikh. "Sex differences in the risk of recurrent ischemic stroke after ischemic stroke and transient ischemic attack." European Stroke Journal 6, no. 4 (2021): 367–73. http://dx.doi.org/10.1177/23969873211058568.

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Background Sex differences in stroke outcomes have been noted, but whether this extends to stroke recurrence is unclear. We examined sex differences in recurrent stroke using data from the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial. Patients and methods We assessed the risk of recurrent stroke in women compared to men using data from the POINT trial. Adults >18 years old were randomized within 12 hours of onset of minor ischemic stroke or transient ischemic attack (TIA), and followed for up to 90 days for ischemic stroke, our primary outcome. We used Cox

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Damayanti, Ervin, and Ceria Nurhayati. "EFFECTIVITY OF OXYGEN THERAPY IN NEUROLOGICAL DEFICITS IN ACUTE ISCHEMIC STROKE PATIENTS." Nurse and Health: Jurnal Keperawatan 14, no. 1 (2025): 39–49. https://doi.org/10.36720/nhjk.v14i1.656.

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Background: Neurological deficits in acute ischemic stroke patients cause disrupted day living activities. The study aimed to analyze the difference in neurological deficits of acute ischemics stroke between patients with oxygen therapy in the stroke center room of Dr. Ramelan Hospital. Objectives: The study sample used total random sampling technique. Variable of this study were neurological deficit, using the NIHSS scale instrument is the National Institute of Health Stroke Scale and using the statistical Mann Whitney test. Methods: The research design used was quasi experiment. The populati

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Wang, Lei, Xu Zhang, Xiaoxing Xiong, et al. "Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke." Antioxidants 11, no. 12 (2022): 2377. http://dx.doi.org/10.3390/antiox11122377.

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Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there are limited effective clinical treatments for cerebral ischemic stroke, and the recovery of cerebral blood circulation will lead to cerebral ischemia-reperfusion injury (CIRI). Cerebral ischemic stroke involves many pathological processes such as oxidative stress, inflammation, and mitochondrial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2), as one of the most critical antioxidant transcript

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Su, Zhongzhou, Yingze Ye, Chengen Shen, et al. "Pathophysiology of Ischemic Stroke: Noncoding RNA Role in Oxidative Stress." Oxidative Medicine and Cellular Longevity 2022 (September 12, 2022): 1–12. http://dx.doi.org/10.1155/2022/5815843.

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Stroke is a neurological disease that causes significant disability and death worldwide. Ischemic stroke accounts for 75% of all strokes. The pathophysiological processes underlying ischemic stroke include oxidative stress, the toxicity of excitatory amino acids, ion disorder, enhanced apoptosis, and inflammation. Noncoding RNAs (ncRNAs) may have a vital role in regulating the pathophysiological processes of ischemic stroke, as confirmed by the altered expression of ncRNAs in blood samples from acute ischemic stroke patients, animal models, and oxygen-glucose-deprived (OGD) cell models. Due to

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Vashchenko, Vladimir I., Elena F. Sorokoletova, and Petr D. Shabanov. "Molecular mechanisms of interaction between ferroptosis and cuproptosis in ischemic stroke. Pharmacological perspectives on preventing brain dysfunction." Psychopharmacology & biological narcology 16, no. 1 (2025): 43–60. https://doi.org/10.17816/phbn653994.

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Ischemic stroke is one of the most severe and common neurological disorders, posing a significant threat to the health and life expectancy of affected individuals. Resulting from impaired blood flow, ischemic stroke leads to hypoxia and cerebral tissue ischemia, triggering a cascade of pathophysiological changes that markedly exacerbate neuronal damage and may ultimately result in cell death. New recent studies increasingly focus on newly discovered mechanisms of cell death, such as ferroptosis and cuproptosis. There is growing evidence supporting the independent roles of ferroptosis and cupro

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Huang, Jyun-Bin, Nai-Ching Chen, Chien-Liang Chen, et al. "Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 Associated with the Severity and Outcome of Acute Ischemic Stroke." Journal of Clinical Medicine 10, no. 1 (2020): 61. http://dx.doi.org/10.3390/jcm10010061.

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Stroke is a neurological emergency, where the mechanism of the blood supply to the brain is impaired, resulting in brain cell ischemia and death. Neuroinflammation is a key component in the ischemic cascade that results in cell damage and death after cerebral ischemia. The triggering receptor expressed on myeloid cells-1 (TREM-1) modulates neuroinflammation after acute ischemic stroke. In the present study, 60 patients with acute ischemic stroke, who had been subjected to neurological examinations and National Institutes of Health Stroke Scale (NIHSS) and brain magnetic resonance imaging studi

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M, Konda, Varalakshmi EA, Patil A, et al. "Risk factors and subtypes of ischemic strokes in young adults: A tertiary care hospital study from southern part of India." Journal of Medical and Scientific Research 13, no. 2 (2025): 101–6. https://doi.org/10.17727/jmsr.2024/13-18.

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Background: In the last few decades ischemic stroke in young adults (15-45 years) has been increasingly reported. This study was aimed to evaluate the epidemiological features, risk factors and mechanisms of ischemic stroke in young adults. Methods: From June 2018 to February 2020, patients diagnosed with ischemic stroke in the age group of 15-45 years from a tertiary care referral hospital in Hyderabad, India, were consecutively enrolled to study their risk factors, mechanisms and outcome. Results: Out of 971 patients of ischemic strokes 164 (16.8%) were young adults, among whom 113 (69%) wer

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Sundukov, Dmitrii I., Vera N. Grigoryeva, Daria A. Pavlova, and Ivan Nikolaevich Vaneev. "Risk Factors for Auditory-Verbal and Visual-Spatial Memory Impairments in Patients with Ischemic Stroke." Neurology Bulletin LVII, no. 2 (2025): 140–49. https://doi.org/10.17816/nb636730.

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INTRODUCTION.: Auditory-verbal and visual-spatial memory impairments, which significantly impact patients' daily functioning, may potentially suggest acute ischemic stroke. However, these impairments are not always recognized by medical professionals at vascular centers. The early detection of significant memory impairments can be facilitated by identifying the factors that increase the probability of detecting such impairments in patients with acute ischemic stroke. AIM: To identify the risk factors associated with significant memory impairments, both auditory-verbal and visual-spatial, in th

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Bernick, Charles B., Lewis H. Kuller, Will T. Longstreth, et al. "Silent Brain MRI Infarcts and Subsequent Stroke Type In the Cardiovascular health Study." Stroke 32, suppl_1 (2001): 363. http://dx.doi.org/10.1161/str.32.suppl_1.363-d.

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P136 Objective: Silent infarcts seen on cranial MRI scans are a risk factor for subsequent clinical stroke in the elderly. This study examines the type of clinical strokes seen in those with silent infarcts. Methods: Cranial MRI examination was completed on 3324 Cardiovascular Health Study (CHS) participants aged 65+ who were without a prior history of clinical stroke. Incident strokes were identified over an average follow-up of 4 years and classified as hemorrhagic or ischemic. Ischemic strokes were further subdivided into lacunar, cardioembolic, atherosclerotic or other/unknown. Results: Si

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Eide, Sarah, and Zhong-Ping Feng. "Implications of age-related changes in the blood-brain barrier for ischemic stroke and new treatment strategies." Advanced Neurology 1, no. 2 (2022): 1. http://dx.doi.org/10.36922/an.v1i2.1.

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Ischemic strokes are prevalent across all age groups. Recent research has highlighted the importance of better understanding ischemia-induced damage of the blood-brain barrier (BBB) because it is related to both the severity of ischemic injury and neurological outcomes. The influence of advancing age on the structure and function of the BBB and the potential influence of these changes on ischemic stroke injury have received little consideration to date. Therefore, the present review outlines how ischemic injury influences the structure and function of the BBB at the anatomical, cellular, and m

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Rogozhina, A. A. "Sphingolipids in ischemic stroke." Ateroscleroz 17, no. 4 (2022): 93–100. http://dx.doi.org/10.52727/2078-256x-2021-17-4-93-100.

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Determination of new biomarkers involved in the pathogenesis of ischemic stroke is an extremely important task from the point of view of identifying possible mechanisms for preventing the occurrence of an acute event, better diagnosis, and influencing the stages of pathogenesis to reduce the inflammatory focus. Sphingolipids belong to new biomarkers of atherosclerosis, which are involved in inflammation, apoptosis, and ischemia. The widespread introduction of mass spectrometry has made it possible to study sphingolipids in more detail. This review aims to summarize the available data on the ro

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Femi S V, Nakshathra R. Nath, Amaya Prasannan, Anurag Maniyath, Susheela Rani, and E. Satheesh Kumar. "A comparative study on risk factors, clinical presentation, recovery rates and cost burden of patients with ischemic and hemorrhagic stroke." Indian Journal of Pharmacy and Pharmacology 11, no. 4 (2024): 205–12. https://doi.org/10.18231/j.ijpp.2024.034.

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Stroke is a significant cause of morbidity and mortality worldwide, with ischemic and hemorrhagic strokes being the two major types. Understanding their distinct risk factors, clinical presentations, recovery rates, and cost burden is crucial for optimizing patient management and healthcare resource allocation.To evaluate and compare the risk factors, clinical presentation, recovery rates, and cost burden associated with ischemic and hemorrhagic strokes in patients admitted to a tertiary care hospital.A comparative observational study was conducted on 300 stroke patients admitted to a tertiary

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Hamblin, Milton H., Austin C. Boese, Rabi Murad та Jean-Pyo Lee. "PPARα Genetic Deletion Reveals Global Transcriptional Changes in the Brain and Exacerbates Cerebral Infarction in a Mouse Model of Stroke". International Journal of Molecular Sciences 26, № 9 (2025): 4082. https://doi.org/10.3390/ijms26094082.

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Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is an unmet clinical need for pharmacological treatments that can improve ischemic stroke outcomes. In this study, we investigated the role of brain peroxisome proliferator-activated receptor alpha (PPARα) in ischemic stroke pathophysiology. We used a well-established model of cerebral ischemia in PPARα transgenic mice and conducted the RNA sequencing (RNA-seq) of mouse stroke brains harvested 48 h post-middle cerebral artery occlusion (MCAO). PPARα knockout (KO) increased brain infarct size following stroke

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Jayantilal, Lalji Sathavara, Datraniya Mohini, and Gamit Dileep. "Comparison of SIRIRAJ Stroke Score with Computerized Tomography in Ascertaining Type among 50 cases of Cerebrovascular Stroke Patients." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 84–88. https://doi.org/10.5281/zenodo.11455546.

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<strong>Background: </strong>Timely diagnosis is especially important in ischemic stroke, because early thrombolytic therapy and anti-platelet drugs not only improve the functional outcome but also reduce mortality and recurrent strokes. Vast majority of patients do not have access to brain imaging. Therefore, the clinical criteria for distinguishing between ischemic and hemorrhagic stroke has been emphasized. <strong>Objectives:</strong> Present study is done with following objectives. To determine the accuracy of the Sirriraj stroke score in differentiating the ischemic from t

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Alotaibi, Badi A., Jehad A. Aldali, Hamzah J. Aldali, et al. "The Risk Factors for Acute Cerebrovascular Accident (Stroke) in Patients with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2)." Viruses 15, no. 5 (2023): 1140. http://dx.doi.org/10.3390/v15051140.

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Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) patients may experience an acute ischemic stroke; however, risk factors, in-hospital deaths, and outcomes have not been thoroughly investigated. This study investigates the risk factors, comorbidities, and outcomes in patients with SARS-VoV-2 infection and acute ischemic stroke compared to patients without these conditions. The present retrospective study was conducted in the King Abdullah International Medical Research Centre (KAIMRC), Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia, during the period from April 2020

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Cabral, Norberto Luiz, Vivian Nagel, Adriana B. Conforto, et al. "High five-year mortality rates of ischemic stroke subtypes: A prospective cohort study in Brazil." International Journal of Stroke 14, no. 5 (2018): 491–99. http://dx.doi.org/10.1177/1747493018806197.

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Background Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil. Methods All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. Results We included 334 ischemic stroke patients. Over five years, 156 died, 51 had a recurrent stroke, and 128 were free of recurrent stroke. The overall cumulative risk of death was 17% (95% CI, 13% to 22%) at 30 days and 47% (95% CI, 41% to 52%) after five years. Undeter

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Rizos, Timolaos, Andreas D. Meid, Andrea Huppertz, et al. "Low Exposure to Direct Oral Anticoagulants Is Associated with Ischemic Stroke and Its Severity." Journal of Stroke 24, no. 1 (2022): 88–97. http://dx.doi.org/10.5853/jos.2020.04952.

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Background and purpose In acute stroke patients, plasma concentrations of direct oral anticoagulants (DOAC) at hospital admission only poorly mirror DOAC exposure or the coagulation status at the time of the event. Here, we evaluated whether DOAC exposure and DOAC plasma concentration at the time of transient ischemic attacks (TIA) and ischemic strokes correlate with their likelihood of occurrence.Methods Prospectively, consecutive DOAC patients with acute ischemic stroke or TIA were included. Admission DOAC plasma concentrations were measured by ultraperformance liquid chromatography– tandem

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Safari, Anahid, Rasool Safari, and Afshin Borhani-Haghighi. "Immunology of stroke." Galen Medical Journal 5 (May 24, 2016): 10–17. http://dx.doi.org/10.31661/gmj.v5is1.592.

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Stroke, a multifactorial disease, has distinct pathophysiologic mechanisms, among which inflammation plays a pivotal role. Various types of inflammatory cells, substances, and molecules emerge in the ischemic stroke. Neutrophils, Tcell subtypes, macrophages, microglial cells, dendritic cell, mast cells, asrocytes, as influential cell, tumor necrosis factor_α, interleukin-17, interleukin-10, as released substances, and vascular cell adhesion molecule-1 (VCAM-1), leukocyte very late antigen-4 (VLA-4), and glial fibrillary acidic protein (GFAP), as cellular adhesion molecules. Lymphocytes' invasi

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