Relevant bibliographies by topics / ISGs phenotype

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Reports

Academic literature on the topic 'ISGs phenotype'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "ISGs phenotype"

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Swieboda, Dominika, Erica Johnson, Ioanna Skountzou, and Rana Chakraborty. "Baby’s First Macrophage: How do placental macrophages (Hofbauer Cells, HCs) contribute to immune tolerance and infection response during pregnancy?" Journal of Immunology 202, no. 1_Supplement (2019): 126.28. http://dx.doi.org/10.4049/jimmunol.202.supp.126.28.

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Abstract Placental immunity is dichotomous: tolerance of the semiallogenic fetus is balanced with limiting transmission of maternal pathogens. HCs are the major fetal immune cell at the placenta, but mechanisms responsible for maintaining immune homeostasis while preventing infection require elucidation. We determined the phenotype of human HCs throughout gestation and analyzed stimulation response. Activated HCs were present in early pregnancy and reduced in number by term while maintaining similar phenotypes. Tolerant HC numbers were highest in midgestation, after a relatively intolerant phe
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Morrison, Robert J., Nicolas-George Katsantonis, Kevin M. Motz, et al. "Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals." Otolaryngology–Head and Neck Surgery 160, no. 1 (2018): 107–15. http://dx.doi.org/10.1177/0194599818803584.

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Objective To characterize the phenotype and function of fibroblasts derived from airway scar in idiopathic subglottic stenosis (iSGS) and to explore scar fibroblast response to interleukin 17A (IL-17A). Study Design Basic science. Setting Laboratory. Subjects and Methods Primary fibroblast cell lines from iSGS subjects, idiopathic pulmonary fibrosis subjects, and normal control airways were utilized for analysis. Protein, molecular, and flow cytometric techniques were applied in vitro to assess the phenotype and functional response of disease fibroblasts to IL-17A. Results Mechanistically, IL-
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Gluchowski, Marcel, Xiaoqiong Yu, Bernard Abrenica, et al. "Transient Increases in Inflammation and Proapoptotic Potential Are Associated with the HESN Phenotype Observed in a Subgroup of Kenyan Female Sex Workers." Viruses 14, no. 3 (2022): 471. http://dx.doi.org/10.3390/v14030471.

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Interferon (IFN) -stimulated genes (ISGs) are critical effectors of IFN response to viral infection, but whether ISG expression is a correlate of protection against HIV infection remains elusive. A well-characterized subcohort of Kenyan female sex workers, who, despite being repeatedly exposed to HIV-1 remain seronegative (HESN), exhibit reduced baseline systemic and mucosal immune activation. This study tested the hypothesis that regulation of ISGs in the cells of HESN potentiates a robust antiviral response against HIV. Transcriptional profile of a panel of ISGs with antiviral function in PB
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Gupta, Sarthak, Shuichiro Nakabo, Luz P. Blanco, et al. "Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism." Proceedings of the National Academy of Sciences 117, no. 28 (2020): 16481–91. http://dx.doi.org/10.1073/pnas.2003603117.

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Differences between female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. We previously reported that neutrophils from reproductive-age males are more immature and less activated than their female counterparts. To further characterize the mechanisms that drive differential neutrophil phenotypes, we performed RNA sequencing on circulating neutrophils from healthy adult females and males. Female neutrophils displayed significant up-regulation of type I IFN (IFN)-stimulated genes (ISGs). Single-cell RNA-sequencing analysis indicated th
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Hancock, Meaghan H., Karen L. Mossman, and James R. Smiley. "Cell Fusion-Induced Activation of Interferon-Stimulated Genes Is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed between Permissive and Restrictive Cells." Journal of Virology 83, no. 17 (2009): 8976–79. http://dx.doi.org/10.1128/jvi.00142-09.

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ABSTRACT Herpes simplex virus VP16 and ICP0 mutants replicate efficiently in U2OS osteosarcoma cells but are restricted in other cell types. We previously showed that the restrictive phenotype is dominant in a transient cell fusion assay, suggesting that U2OS cells lack an antiviral mechanism present in other cells. Recent data indicate that unscheduled membrane fusion events can activate the expression of interferon-stimulated genes (ISGs) in fibroblasts, raising the possibility that our earlier results were due to a fusion-induced antiviral state. However, we show here that the permissive ph
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Jurczyszak, Denise, Lara Manganaro, Sofija Buta, et al. "ISG15 deficiency restricts HIV-1 infection." PLOS Pathogens 18, no. 3 (2022): e1010405. http://dx.doi.org/10.1371/journal.ppat.1010405.

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Type I interferons (IFN-Is) are a group of potent inflammatory and antiviral cytokines. They induce IFN stimulated genes (ISGs), which act as proinflammatory mediators, antiviral effectors, and negative regulators of the IFN-I signaling cascade itself. One such regulator is interferon stimulated gene 15 (ISG15). Humans with complete ISG15 deficiency express persistently elevated levels of ISGs, and consequently, exhibit broad spectrum resistance to viral infection. Here, we demonstrate that IFN-I primed fibroblasts derived from ISG15-deficient individuals are more resistant to infection with s
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Chan, Jennie, Peter Liehl, Rosane DeOliveira, et al. "Dual role of type I IFN during plasmodium infection (P3056)." Journal of Immunology 190, no. 1_Supplement (2013): 125.6. http://dx.doi.org/10.4049/jimmunol.190.supp.125.6.

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Abstract The molecular mechanisms regulating the inflammatory response during malaria are still poorly defined. Inflammatory cytokines and type I IFNs induced when innate immune sensors recognize components of the malaria parasite can contribute to clearance of the parasite and in some circumstances these same effectors lead to experimental cerebral malaria (ECM). Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) leads to ECM where animals succumb to infection and die. Upon infection with PbA infected red blood cells (iRBCs), C57/Bl6 mice succumb to death 6-12 days post-infection. R
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Thomas, Emmanuel, Mazen Noureddin, Yaron Rotman, and T. Jake Liang. "Mechanism of induction and genotype-phenotype correlation of IL28B and ISG expression in HCV-infected primary human hepatocytes and liver (P1383)." Journal of Immunology 190, no. 1_Supplement (2013): 57.3. http://dx.doi.org/10.4049/jimmunol.190.supp.57.3.

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Abstract Background: IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs. However, the intrinsic innate immune response following HCV infection remains poorly understood. Methods: Immunofluorescence staining of innate immune molecules (IRF3, ISG15) were performed on HCV infected PHHs. PHHs were also studied for correlation of IL28 genotype with type III IFN and ISG expression. In addition, RNA was extracted from 60 pre-treatment archived liver biopsies and hepatic expression of IFNs was measured by qPCR. Rs12979860 genotype
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Foxman, Ellen F., James A. Storer, Megan E. Fitzgerald, et al. "Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells." Proceedings of the National Academy of Sciences 112, no. 3 (2015): 827–32. http://dx.doi.org/10.1073/pnas.1411030112.

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Most isolates of human rhinovirus, the common cold virus, replicate more robustly at the cool temperatures found in the nasal cavity (33–35 °C) than at core body temperature (37 °C). To gain insight into the mechanism of temperature-dependent growth, we compared the transcriptional response of primary mouse airway epithelial cells infected with rhinovirus at 33 °C vs. 37 °C. Mouse airway cells infected with mouse-adapted rhinovirus 1B exhibited a striking enrichment in expression of antiviral defense response genes at 37 °C relative to 33 °C, which correlated with significantly higher expressi
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Ganguly, Payal, Agata Burska, Charlotte Davis, Jehan J. El-Jawhari, Peter V. Giannoudis та Elena Jones. "Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45lowCD271+ Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation". Biomedicines 8, № 7 (2020): 214. http://dx.doi.org/10.3390/biomedicines8070214.

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Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential stromal cells (MSCs). Recent data suggest the involvement of type 1 interferon (IFN1) signalling in hematopoietic stem cell (HSC) senescence. Considering that BM-HSCs and BM-MSCs share the same BM niche, we investigated IFN1 expression profile in human BM-MSCs in relation to donor age, culture-expansion and IFN1 (α and β) stimulation. Fluorescence-activated cell sorting was used to purify uncultured BM-MSCs from younger (19–41, n = 6) and older (59–89, n = 6) donors based on the CD45lowCD271+ p
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Dissertations / Theses on the topic "ISGs phenotype"

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RAUS, Svjetlana. "Reversion of anti-viral status in human tumors." Doctoral thesis, 2014. http://hdl.handle.net/11562/694361.

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Le terapie con virus oncolitici stanno diventando una possibile alternativa per tumori difficilmente trattabili con le terapie standard. Il nostro gruppo ha dimostrato l’esistenza in cellule neoplastiche di due possibili fenotipi distinguibili in base all’espressione di geni stimolati dagli interferoni (ISGs) e di geni indotti dallo stress virale (VSIG) che possono essere facilmente distinti utilizando la proteina MxA come marcatore. Abbiamo dimostrato che l’esistenza di questo fenotipo ISGs e’ capace di bloccare nelle cellule tumorali sia la lisi virale sia l’espressione genica di proteine
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Book chapters on the topic "ISGs phenotype"

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Berga, Sarah L. "The Brain Phenotype in Polycystic Ovary Syndrome (PCOS): Androgens, Anovulation, and Gender." In ISGE Series. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63650-0_1.

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Iaremenko, Oleg, and Daria Koliadenko. "CLINICAL PHENOTYPES OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH REGARD TO AGE AT DISEASE ONSET." In Traditional medicine and pharmacology. Achievements, innovations, and alternatives. International Science Group, 2021. http://dx.doi.org/10.46299/isg.2021.mono.med.ii-56-61.

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Ellison, Jay w. "SHOX and Dyschondrosteosis and Turner Syndrome." In Inborn Errors Of Development. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195306910.003.0077.

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Abstract The story of the short stature homeobox (SHOX) gene is an example of how observations of different clinical disorders can eventually converge on a single gene. The disorders in this case are dyschondrosteosis, a skeletal dysplasia; Turner syndrome, an aneuploid condition resulting from a missing sex chromosome; and idiopathic short stature (ISS). SHOX is implicated in each of these conditions, although its contribution to the phenotypes varies with respect to both level of involvement and level of experimental proof. The predicted nature of the gene product (as a DNA-binding transcrip
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Reports on the topic "ISGs phenotype"

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Blum, Abraham, and Henry T. Nguyen. Molecular Tagging of Drought Resistance in Wheat: Osmotic Adjustment and Plant Productivity. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7580672.bard.

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Drought stress is a major limitation to bread wheat (Triticumaestivum L.) productivity and its yield stability in arid and semi-arid regions of world including parts of Israel and the U.S. Currently, breeding for sustained yields under drought stress is totally dependent on the use of yield and several key physiological attributes as selection indices. The attempt to identify the optimal genotype by evaluating the phenotype is undermining progress in such breeding programs. Osmotic adjustment (OA) is an effective drought resistance mechanism in many crop plants. Evidence exists that there is a
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