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Journal articles on the topic 'Islands of Langerhans'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Barakat, Hassan, Khaled Al-Roug, Raya Algonaiman, et al. "Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats." Molecules 28, no. 3 (2023): 940. http://dx.doi.org/10.3390/molecules28030940.

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Numerous food organizations have identified excessive calorie consumption and accompanying ailments as significant health risks associated with high sugar consumption. Administering stevioside (ST), sucralose (SU), and the two synergically (SU+ST) affected normal rats’ weight gain. In the current study, SU showed the highest undesired effect. Indeed, administering the three treatments to diabetic rats (DR) did not improve the rats’ weight gain. Although, insulin injection synergically with the treatments improved the weight gain, as recorded after three weeks. The best-improving rate was obser

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Aleydaputri, Andarista Diaz, and Nur Kuswanti. "Efek Ekstrak Daun Sawo Manila (Manilkara zapota L.) terhadap Profil Pulau Langerhans dan Berat Badan Mencit Diabetes." LenteraBio : Berkala Ilmiah Biologi 11, no. 1 (2021): 122–30. http://dx.doi.org/10.26740/lenterabio.v11n1.p122-130.

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Diabetes melitus adalah penyakit gangguan metabolisme. Penelitian bertujuan mengetahui pengaruh ekstrak daun sawo manila terhadap profil pulau Langerhans dan berat badan mencit diabetes. Studi ini merupakan penelitian ekperimental menggunakan RAL dengan 6 kelompok (kontrol normal, kontrol aloksan, dosis ekstrak 1 (28mg/kg BB), dosis ekstrak 2 (56mg/kg BB), dosis ekstrak 3 (112mg/kg BB) dan glibenclamide), masing-masing dengan 4 ulangan. Mencit diabetes induksi aloksan diberi ekstrak daun sawo dua kali sehari selama 14 hari. Profil pulau Langerhans ditentukan berdasarkan diameternya melalui pen

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3

Raffel, Andreas, Claus F. Eisenberger, Kenko Cupisti, et al. "Increased EpCAM expression in malignant insulinoma: potential clinical implications." European Journal of Endocrinology 162, no. 2 (2010): 391–98. http://dx.doi.org/10.1530/eje-08-0916.

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ObjectiveEpCAM (CD326) is overexpressed in progenitor cells of endocrine pancreatic islands of Langerhans during fetal development and was suggested to act as a morphoregulatory molecule in pancreatic island ontogeny. We tested whether EpCAM overexpression is reactivated in insulinomas, endocrine tumors arising in the pancreas.Design/methodWe used monoclonal anti-EpCAM antibody Ber-Ep4 for immunohistochemistry on formalin-fixed and paraffin-embedded tumor material. We analyzed 53 insulinomas: 40 benign (disease stage<IIa) and 13 malignant tumors (disease stage IIIb/IV). Disease stage dispos

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Jassim Abd, Sarah, and Satar Abood Faris. "Effect of Streptozocin on the Langerhans Islands in the pancreas of birds." Sumer 1 8, CSS 1 (2023): 1–8. http://dx.doi.org/10.21931/rb/css/2023.08.01.89.

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In the current study, birds (Columba livia ) were used as a new model to study the effect of streptozotocin on the pancreas gland and the blood glucose level. Three concentrations of 75,65,55 mg/kg were adopted for five consecutive days with one IP dose daily. The experimental animals showed a gradual rise in blood glucose the average glucose in the first week of the experiment was usual for the three groups compared with the control group, while there was a significant change in the blood glucose level in the three groups at the end of the experiment (4th week), where the average glucose in t

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5

Da Silva Xavier, Gabriela. "The Cells of the Islets of Langerhans." Journal of Clinical Medicine 7, no. 3 (2018): 54. http://dx.doi.org/10.3390/jcm7030054.

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Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to help advance such treatment modalities: what should be the target islet/β-cell mass, does islet architecture matter to energy homeostasis, and what may happen if we lose a particular population of islet cells in favour of β-cells? These are all questions to which we wil

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Hultquist, Gosta T., and Bo Thorell. "CYTOLOGICAL CHANGES DURING THE EMBRYONAL FORMATION OF LANGERHANS' ISLANDS AS REVEALED BY ULTRAVIOLET MICROSCOPY." Acta Pathologica Microbiologica Scandinavica 32, no. 2 (2009): 245–50. http://dx.doi.org/10.1111/j.1699-0463.1953.tb00249.x.

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7

BEEK, CORNELIA, A. J. CH HAEX, and P. J. KOOREMAN. "Two cases of spontaneous hypoglycemia due to a tumor of the islands of Langerhans." Acta Medica Scandinavica 112, no. 2 (2009): 164–87. http://dx.doi.org/10.1111/j.0954-6820.1942.tb10011.x.

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TOVAR-HERNÁNDEZ, MARÍA ANA. "On some species of Chone Krøyer, 1856 (Polychaeta: Sabellidae) from world-wide localities." Zootaxa 1518, no. 1 (2007): 31–68. http://dx.doi.org/10.11646/zootaxa.1518.1.2.

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The present study deals with the revision of type and non-type material from species of Chone Krøyer, 1856 (Polychaeta: Sabellidae) that have been described from world-wide isolated localities. Chone australiensis Hartmann-Schröder, 1979, C. fauveli McIntosh, 1916, C. kroyerii Sars, 1862, C. letterstedti (Kinberg, 1867), C. murmanica Lukasch, 1910, C. normani McIntosh, 1916, C. paracincta Hartmann-Schröder, 1962, and C. rosea Hartmann-Schröder, 1965, are redescribed. Two additional forms are recognized as independent taxa, referred to as Chone sp. “Aleutian Islands” and Chone sp. “British Virg

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9

Myint, Myat Su Mon, and Antonio Pinero-Pilona. "LBSAT310 A Rare Disease Engulfing Thyroid And Masquerading As Common Thyroid Disorders." Journal of the Endocrine Society 6, Supplement_1 (2022): A747—A748. http://dx.doi.org/10.1210/jendso/bvac150.1542.

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Abstract Introduction – Langerhans cell histiocytosis (LCH) is a rare clonal disorder caused by the CD207+ Langerhans cells derived from the myeloid origin. We present a case of LCH where it mimicked Hashimoto's and Riedel's thyroiditis and completely infiltrated the thyroid gland. Case description – A 54-year-old female was initially diagnosed with hypothyroidism, goiter, and bilateral parotid and submandibular glands enlargement. CT imaging revealed a diffuse goiter which imposed infraglottic airway narrowing and a suspicious left inferior thyroid nodule. Biopsy revealed atypia of undetermin

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10

Al-Sharoot, Hassaneen Ali. "Anatomical, Histological and Histochemical Architecture of pancreases in Early Hatched Goose (Anser anser)." Kufa Journal For Veterinary Medical Sciences 7, no. 1 (2016): 147–53. http://dx.doi.org/10.36326/kjvs/2016/v7i14282.

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The present work includes anatomical, histological and histochemical study of the pancreas in early hatched Goose (Anser anser). The current study was performed on ten early-hatched goose ageing from 5-10 dayes clinically healthy. The animals were anaesthetized by the ether after which they were carefully dissected and examined. Anatomical study shown pancreas it is a vital lobulated organ, pale pinkish in coular, located on the right side of the abdominal cavity between the descending and ascending duodenal loops closely covered by mesentery pancreatic duodenal ligament and Its consist of dor

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Al-Sharoot, Hassaneen Ali. "Anatomical, Histological and Histochemical Architecture of pancreases in Early Hatched Goose (Anser anser)." Kufa Journal For Veterinary Medical Sciences 7, no. 1 (2016): 147–53. http://dx.doi.org/10.36326/kjvs/2016/v7i14282.

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The present work includes anatomical, histological and histochemical study of the pancreas in early hatched Goose (Anser anser). The current study was performed on ten early-hatched goose ageing from 5-10 dayes clinically healthy. The animals were anaesthetized by the ether after which they were carefully dissected and examined. Anatomical study shown pancreas it is a vital lobulated organ, pale pinkish in coular, located on the right side of the abdominal cavity between the descending and ascending duodenal loops closely covered by mesentery pancreatic duodenal ligament and Its consist of dor

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Tan, Esa Indah Ayudia, Irfannuddin Irfannuddin, and Krisna Murti. "PENGARUH DIET KETOGENIK TERHADAP PROLIFERASI DAN KETAHANAN SEL PADA JARINGAN PANKREAS." JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" 7, no. 1 (2019): 102–16. http://dx.doi.org/10.22437/jmj.v7i1.7127.

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ABSTRACT  The ketogenic diet is a diet that uses a lot of fat as an energy source and reduces carbohydrate and protein consumption when the body does not get enough glucose from carbohydrates, the body usually uses alternative energy sourced from the ketone body, namely acetoacetate and b-hydroxybutyrate. The ketone body comes from the breakdown of fatty acid metabolism in the liver where at the moment the concentration is low in the blood. Ketogenic diet is a diet that uses a lot of fat as an energy source and reduces carbohydrate consumption. The ketogenic diet makes the body burn fat

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13

ZONDEK, HERMANN, and GERDA WOLFSOHN. "A Contribution to the Question of the Secretion of the Fetal Islands of Langerhans. (Blood Sugar Analyses in the Newborn.)." Acta Medica Scandinavica 106, no. 5-6 (2009): 468–78. http://dx.doi.org/10.1111/j.0954-6820.1941.tb09097.x.

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14

Pramanik, Farina, Lusi Epsilawati, Yurika Ambar Lita, and Erna Herawati. "Analisis gambaran radiologis suspek ameloblastoma tipe solid pada radiograf CBCT 3D." Jurnal Radiologi Dentomaksilofasial Indonesia 3, no. 2 (2019): 15. http://dx.doi.org/10.32793/jrdi.v3i2.492.

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Objectives: The aim of this case report is to provide further information on the radiological features of a solid type ameloblastoma suspected on a 3D CBCT radiograph. Case Report: A patient came referred by a dentist for CBCT 3D radiography with suspected clinical diagnosis of a maxillary anterior dentigerous cyst. The results of the CBCT 3D radiographic examination showed a radiointermediate with a clear border on the anterior maxilla and in the right maxillary sinus accompanied by the impact of two supernumerary teeth. Radiological features of ameloblastoma generally show a multilocul

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15

Fitri, Yenni, and Elsa Yuniarti. "Effect of Boiled Water Tithonia diversifolia A. Gray Leaf Against the Pancreas Histology in Mus musculus L. Induced by Alloxan." Bioscience 3, no. 1 (2019): 69. http://dx.doi.org/10.24036/0201931103432-0-00.

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Traditional medicine is one of the drugs used by the community to be one of the efforts to treat diseases. One of them is Diabetes Mellitus (DM). DM is a metabolic disease characterized by hyperglycemia which results in an increase in free radicals in the cell. DM treatment is quite expensive so an alternative drug is needed. One of them is Tithonia diversifolia A. Gray. This study used a completely randomized design, consisting of 1 control, 4 treatments (P1: Only alloxan induced), P2: Alloxan 65 mg / kg BB, P3: Metformin 65 mg / kg BB, P4: Boiled leaves of moon leaves 24.6 mg / 10 ml and P4:

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16

Brink, Stuart J. "Insulin Past, Present, and Future: 100 Years from Leonard Thompson." Diabetology 3, no. 1 (2022): 117–58. http://dx.doi.org/10.3390/diabetology3010010.

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Before the discovery of insulin and the critical role of the pancreas vis-à-vis diabetes mellitus pathophysiology, childhood diabetes or what we now call type 1 or autoimmune diabetes mellitus was almost universally fatal. In limited-resource countries (LRC) around the world, this remains sadly true because of the expense and unavailability of medical care, medical information, and/or medications. In 1889, Minkowski and Mering identified the pancreas as the likely source of the problem in pancreatectomized dog experiments, and Langerhans, working with Virchow, identified the islands of pancrea

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Ashrafihelan, Javad, Jamileh Salar Amoli, Mehran Alamdari, et al. "Arsenic toxicosis in sheep: The first report from Iran." Interdisciplinary Toxicology 6, no. 2 (2013): 93–98. http://dx.doi.org/10.2478/intox-2013-0016.

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Abstract Arsenic contamination of groundwater has been previously reported in Ghopuz, a village located in the Northwest of Iran. Samples were taken from consuming and irrigation water and plants of the region for chemical analysis. A seven-year old ewe, which had lived in and fed a lifelong at the same place, with clinical signs such as weakness, wasting and inappropriate integument was necropsied. Grossly, buccal erosion, stomatitis, cutaneous ulcers and serous atrophy of fat deposits were observed. Rumen contents, wool and several tissue samples were obtained for toxicological and histopath

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Taheri, Horiyie, Mehran Mesgari-Abbasi, and Mahdieh Abbasalizad-Farhangi. "Spleen and Pancreatic Tissue Change after Genetically Modified Soybean Oil Consumption Among Male Wistar Rats." International Journal of Drug Research in Clinics 2 (February 21, 2024): e5. http://dx.doi.org/10.34172/ijdrc.2024.e5.

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<strong data-sider-select-id="b8bf10e1-996e-4fe0-a16e-f65aaaaf6a6c">Background: Over the past 20 years, the increased consumption of transgenic products for humans and animals led to the conduction of nutritional studies in this regard. However, these studies were limited, and they did not find a definitive answer to the possible health hazards of transgenic products. Therefore, this study was designed to evaluate the effects of a diet containing transgenic soybean oil on rats. <strong data-sider-select-id="0d24514e-9731-4303-8701-71ae0f71f52c">Methods: Accordingly, male Wistar rat

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Salmon-Divon, Mali, Refael Meyuchas, Jamal Benhamida, et al. "Deciphering the Epigenetic Landscape in Histiocytic Neoplasms." Blood 142, Supplement 1 (2023): 1161. http://dx.doi.org/10.1182/blood-2023-185965.

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Background: Histiocytic neoplasms are driven by mutations activating the MAPK/ERK pathway; however, their epigenetic landscape remains poorly understood. MicroRNAs (miRNAs) are epigenetic regulators implicated in cancer development. Moreover, DNA methylation of miRNAs affects hematological malignancies development. Our previous study identified a unique miRNA expression signature in Erdheim-Chester Disease (ECD) patients. To further understand the biological mechanisms of ECD, we investigated the involvement of miRNAs, genes, and their methylation status in ECD, Langerhans cell histiocytosis (

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Ismawati, Ismawati, Mukhyarjon Mukhyarjon, Ilhami Romus, and Dinda Sonia. "Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2." Jurnal Gizi Klinik Indonesia 16, no. 2 (2019): 58. http://dx.doi.org/10.22146/ijcn.31701.

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Effect of alpha lipoic acid on insulitis in type 2 diabetic ratBackground: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of Wistar strain were segregated into three groups (n=5) labeled as co

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Voltarelli, Julio C., Carlos E. B. Couri, Maria-Carolina B. Oliveira, et al. "Autologous Hematopoietic Stem Cell Transplantation for Type I Diabetes Mellitus." Blood 104, no. 11 (2004): 5224. http://dx.doi.org/10.1182/blood.v104.11.5224.5224.

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Abstract Insulin-dependent type I diabetes mellitus (IDDM) is caused by autoimmune destruction of pancreatic β-islet cells mediated by inflammatory T cells. The pathogenic process evolves gradually for several years and becomes symptomatic when most Langerhans islands are destroyed. Antibodies against β-cell antigens (like anti-glutamic acid decarboxylase, GAD) are markers of the autoimmune reaction and levels of proinsulin C-peptide correlate with endogenous insulin secretion. Several immunosuppressive regimens have demonstrated clinical and laboratorial benefit in early onset IDDM, presumabl

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Ningsih, Purnama, Sitti Rahmawati, Baharuddin Hamzah, et al. "Histology of hematoxylin–eosin and immunohistochemical diabetes rat pancreas after giving combination of moringa leaves (Moringa oleifera) and clove flower (Syzygium aromaticum) extracts." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 257–62. http://dx.doi.org/10.3889/oamjms.2021.5928.

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The purpose of this study was to determine the regeneration activity of pancreatic beta cells by a combination of the ethanol extracts of Moringa leaves and Clove flower. These extracts prepared by maceration with ethanol as solvent . This is an experimental laboratory research by using post test only group design . The subject of this research is 40 white male rats of Wistar strain ( Rattus norvegicus ) and were conditioned DM by streptozotozine-nicotinamide induction . The rats randomly divided into 8 groups , and each group consisted of 5 rats . Combination dose of Moringa leaves and Clove

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Sassa, Mariko, Yasuhiro Iwanaga, and Yuichiro Yamada. "3. Transplantation of Island of Langerhans and Regenerative Therapy." Nihon Naika Gakkai Zasshi 98, no. 4 (2009): 817–23. http://dx.doi.org/10.2169/naika.98.817.

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Tandri, Taufan Hendra, Wiryatun Lestariana, and Fatma Zuhrotun Nisa. "Ekstrak air daun ceplikan (Ruellia tuberosa L.) serta pengaruhnya terhadap kadar glukosa darah dan gambaran histologis pankreas tikus putih (Rattus norvegicus) diabetes mellitus." Jurnal Gizi Klinik Indonesia 6, no. 2 (2009): 64. http://dx.doi.org/10.22146/ijcn.17713.

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Background: Effective control of blood glucose and activities of antioxidant are key factors that prevent diabetes mellitus (DM) and its complications. There are lots of herbal plants that have those both effects. Ceplikan leaves (Ruellia tuberosa L.) is a traditional medicine which is empirically used to lower blood glucose level. Instead of antioxidant compound, there is assumed other compound in ceplikan leaves that has side effect to pancreatic beta cells.Objective: To identify the effect of ceplikan leaves extract to blood glucose level and pancreas histology description in white diabetic

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Gagaev, S. Yu. "First record of a fossil serpulid tube (Polychaeta: Serpulidae) from the Miocene sediments of Sakhalin (NW Pacific)." Zoosystematica Rossica 31, no. 2 (2022): 286–88. http://dx.doi.org/10.31610/zsr/2022.31.2.286.

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A fossil tube of a polychaete from the family Serpulidae Rafinesque, 1815 was found during an expedition of the Zoological Institute of the Russian Academy of Sciences in 1998 in the western part of Sakhalin Island. The fossil is dated to the Middle–Late Miocene. There were no previous records of fossil serpulids in the area. Based on the examination of the morphology and microstructure of the tube, it was established that the fossil belongs either to the genus Chitinopoma Levinsen 1884 or to Filogranula (Langerhans, 1884) and is very similar to the tube of the species Chitinopoma rzhavskii (K

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BAILEY-BROCK, JULIE H., and WAGNER F. MAGALHÃES. "A new species and record of Serpulidae (Annelida: Polychaeta) from Cross Seamount in the Hawaiian Chain." Zootaxa 3192, no. 1 (2012): 49. http://dx.doi.org/10.11646/zootaxa.3192.1.4.

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A new species of the serpulid genus Metavermilia Bush, 1905 and a new record of the genus Omphalopomopsis Saint-Joseph, 1894 are described from deep-sea lava rocks collected from 2,013 m at Cross Seamount, southwest of the Hawaiiarchipelago. Metavermilia zibrowii sp. nov., differs from its congeners mostly by the presence of a simple and concaveoperculum, extent of the thoracic membrane and tube morphology. Omphalopomopsis langerhansii (Marenzeller, 1885)is the type species of the genus and it is only known through its type specimen. This species is characterized by a simpleoperculum with a sh

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Setiawan, Muhammad Azdar, Muhammad Syaiful Saehu, and Kartini Kartini. "Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)." WARTA FARMASI 8, no. 2 (2019): 43–52. http://dx.doi.org/10.46356/wfarmasi.v8i2.94.

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ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosi

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Colovic, Radoje, Marjan Micev, Nikica Grubor, and Vladimir Radak. "Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease." Vojnosanitetski pregled 64, no. 3 (2007): 219–22. http://dx.doi.org/10.2298/vsp0703219c.

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Background. Somatostatinomas of the gastrointestinal tract secret hormone somatostatin which can cause "inhibitory syndrome" comprising diabetes mellitus, cholelithiasis and steatorrheic diarrhea. It is also secreted by the D cells of Langerhans's islands of the pancreas as well as endocrine cells of the stomack, small bowel, salivary glands and parafollicular cells of the thiroid gland. Somatostatinomas of the digestive tract appear within the pancreas and duodenum. Patients suffering from von Recklinghausens's disease are paticularly prone to the somatostatinomas of the duodenum. Case report

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Lewis, Julia M., Patrick F. Monico, Fatima N. Mirza та ін. "Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion". Proceedings of the National Academy of Sciences 118, № 37 (2021): e2016963118. http://dx.doi.org/10.1073/pnas.2016963118.

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Chronic ultraviolet (UV) radiation exposure is the greatest risk factor for cutaneous squamous cell carcinoma (cSCC) development, and compromised immunity accelerates this risk. Having previously identified that epidermal Langerhans cells (LC) facilitate the expansion of UV-induced mutant keratinocytes (KC), we sought to more fully elucidate the immune pathways critical to cutaneous carcinogenesis and to identify potential targets of intervention. Herein, we reveal that chronic UV induces and LC enhance a local immune shift toward RORγt+ interleukin (IL)-22/IL-17A–producing cells that occurs i

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Fugere, Tyler, Brad Fugere, Fnu Amisha, et al. "Interdigitating Dendritic Cell Sarcoma and Indeterminate Dendritic Cell Tumor: Patient Characteristics, Prognostic Factors, and Survival Outcomes for Rare Dendritic Cell Neoplasms." Blood 142, Supplement 1 (2023): 5346. http://dx.doi.org/10.1182/blood-2023-187700.

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Background Dendritic cells are nonlymphoid, nonphagocytic, antigen-presenting cells present in lymphoid and nonlymphoid tissue. There are 4 types of dendritic cells: follicular, interdigitating, Langerhans, and fibroblastic cells. The WHO 2022 classification system groups dendritic cell and histiocytic neoplasms into 3 categories: plasmacytoid dendritic cell neoplasms, Langerhans cell and other dendritic cell neoplasms, and histiocytic neoplasms. The 2nd category is subdivided into “Langerhans cells neoplasms” and “other dendritic cell neoplasms”, which contains indeterminate dendritic cell tu

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Casey, Mycal, Monirul Islam, Mahran Shoukier, Lorriane Odhiambo, and Jorge E. Cortes. "Are Pivotal Trials for Drugs Approved for Leukemia, Myelodysplastic Syndromes, and Multiple Myeloma Representative of the Population Demographics Affected By These Diseases?" Blood 138, Supplement 1 (2021): 846. http://dx.doi.org/10.1182/blood-2021-151235.

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Abstract Background: There are significant disparities in cancer care and outcomes. Many new drugs have been recently approved for hematologic malignancies through randomized clinical trials (RCTs). Equitable population participation in RCTs is important to ensure proper representation of the populations suffering from the malignancies being targeted. It is uncertain whether patients enrolled in clinical trials represent the demographics of a given malignancy. In this study, we evaluate the extent to which trials match disease burden and how trial methods and results differ across racial/ethni

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Dharma, Surya, Dedy Almasdy, Dwisari Dillasamola, Roslinda Rasyid, Dianty Dwi Wahyuni та Fadhilah Afifi. "THE EFFECT OF AMINO ACID COMPOUNDS IN FERMENTED SOYBEANS AGAINST FIBROBLAST GROWTH FACTOR IN MICE PANCREATIC β-CELLS FIGURES". Asian Journal of Pharmaceutical and Clinical Research 11, № 9 (2018): 157. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.26475.

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Objective: The aim of this study is to determine the effect of the amino acid compound in fermented soybeans against fibroblast growth factor (FGF) in mice’s pancreatic β-cell figures. This study was also done to know the effect of given combination of fertilized egg whites powder with tempe (Indonesian conventional food and the fermentation product of soybeans fermentation) in a dose of 7250 mg/kg.Methods: All of the experimental animals pancreases were designed to be damaged by given alloxan in a dose of 150 mg/kg, except for the negative control group without anything given. The experimenta

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Mohammed, Sarah W., Zainab M. Qassam, Ekhlass M. Taha, and Nameer M. Salih. "Role of F-box WD Repeat Domain Containing 7 in Type 1 Diabetes." Ibn AL-Haitham Journal For Pure and Applied Sciences 36, no. 3 (2023): 167–76. http://dx.doi.org/10.30526/36.3.3030.

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Type I diabetes (T1DM) is a chronic immune system disease characterized by the devastation or injury of ß-cells in the Langerhans Island, resulting in insulin deficiency and hyperglycemia. This study determines the new marker F-box and WD repeat domain containing 7 (FBXW7). One hundred twenty type 1 diabetic patients from three different places (central child hospital, Alkindi center for diabetes and endocrinology, Children’s Education Hospital) in Iraq during the period from (20 December 2021 to 25 March 2022) an age ranges of (4-17) years. The patient group consisted of being derived to thre

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Desai, Krishna, Kristal Pereira, Sivaguha Yadunath Prabhakaran, et al. "Anatomical and demographic prognosticators of pancreatic cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e16310-e16310. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e16310.

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e16310 Background: Pancreatic cancer is known to have one of the poorest median of survival (mOS) of all cancers. It is now the third leading cause of cancer-related mortality after lung & colorectal cancer. With the current trends, understanding & knowing prognosticators can aid in determining outcomes of pancreatic cancer. Methods: The data was collected from Surveillance, Epidemiology and End Result database Research Plus Data, 17 Registries, Nov 2022 Sub (2000-2020). We extracted pancreatic cancer cases based on primary site encoding for head, body & tail of pancreas, Islets of

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Kovpak, V. V. "Вплив трансплантації культур клітин на перебіг експериментального цукрового діабету у тварин". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, № 78 (2017): 41–47. http://dx.doi.org/10.15421/nvlvet7809.

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As we know from the literature data, type 1 diabetes mellitus occurs due to the loss of β-cells of island of Langerhans, manufacturing insulin, by the organism, which causes its deficiency. The treatment of this type of diabetes, even at early stages, lies in the substitution therapy together with a careful control of blood glucose which may last for life. It is for this reason that the cellular technologies as an alternative method of treatment of this pathology are growing more and more relevant.Objective of the study: to study the impact of allogenic transplantation of the cultures of bone

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Susilawati, Elis, I. Ketut Adnyana, and Neng Fisheri. "Aktivitas ekstrak etanol daun singawalang (Petiveria alliacea L.) dan fraksinya sebagai antidiabetes." Kartika : Jurnal Ilmiah Farmasi 5, no. 2 (2017): 68. http://dx.doi.org/10.26874/kjif.v5i2.113.

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<p><strong>Abstrak</strong><strong></strong></p><p><strong> </strong></p><p>Diabetes melitus (DM) adalah sekelompok gangguan metabolik yang ditandai dengan hiperglikemia. Salah satu tanaman yang mempunyai efek antidiabetes adalah daun singawalang (<em>Petiveria alliacea</em> L.). Penelitian ini bertujuan untuk menguji aktivitas antidiabetes dengan model hewan defisiensi insulin dan penghambatan enzim alfa glukosidase. Pengujian defisiensi insulin dilakukan menggunakan mencit induksi aloksan. Mencit dikelompokkan menj

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Susilawati, Elis, I. Ketut Adnyana, and Neng Fisheri. "Aktivitas ekstrak etanol daun singawalang (Petiveria alliacea L.) dan fraksinya sebagai antidiabetes." Kartika : Jurnal Ilmiah Farmasi 5, no. 2 (2018): 68. http://dx.doi.org/10.26874/kjif.v5i2.131.

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<p><strong>Abstrak</strong><strong></strong></p><p><strong> </strong></p><p>Diabetes melitus (DM) adalah sekelompok gangguan metabolik yang ditandai dengan hiperglikemia. Salah satu tanaman yang mempunyai efek antidiabetes adalah daun singawalang (<em>Petiveria alliacea</em> L.). Penelitian ini bertujuan untuk menguji aktivitas antidiabetes dengan model hewan defisiensi insulin dan penghambatan enzim alfa glukosidase. Pengujian defisiensi insulin dilakukan menggunakan mencit induksi aloksan. Mencit dikelompokkan menj

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Sarbaz Hoseini, Zahra, Mahdi Alizadeh Vaghasloo, Shima Ababzadeh, et al. "The Effect of Combination Therapy (Thermal Therapy and Oxymel) on Insulin Resistance and Langerhans Islands in Diabetic Rats." Iranian Red Crescent Medical Journal 21, no. 8 (2019). http://dx.doi.org/10.5812/ircmj.90752.

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Yaturramadhan Harahap, Hasni, Cory Linda Futri, Dalimunthe Aminah, and Widyawati Tri. "Dayak Onion Tuber (Eleutherine Bulbosa (Mill) (Urb) Extract Ethanol Test on The Histopatological Description of Pancreas Wistar Rat Inducted Streptozotocin." KnE Social Sciences, March 3, 2023. http://dx.doi.org/10.18502/kss.v8i4.12972.

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This study aimed to determine the effect of Dayak Union tuber (Eleutherine bulbosa (Mill) Urb) ethanol extract on the regeneration of pancreatic β cells of Wistar rats induced streptozotocin. This research is laboratory experimental study by using 30 rats, they are divided into 5 groups, each group consisting of 6 rats, they are group 1 (normal control), group 2 (sick control) was given Na CMC 1 % b/v, Group 3 (positive control) was given glibenclamide at a dose of 0.25 mg / KgBW, Group 4,5 and 6 were given (Eleutherine bulbosa (Mill) Urb) extract at a dose of 125 mg / KgBB, 250 mg / KgBB and

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Corbin, Kathryn L., Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch, and Craig S. Nunemaker. "A Practical Guide to Rodent Islet Isolation and Assessment Revisited." Biological Procedures Online 23, no. 1 (2021). http://dx.doi.org/10.1186/s12575-021-00143-x.

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AbstractInsufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since insulin is released by the islets of Langerhans, obtaining viable and functional islets is critical for research and transplantation. The effective and efficient isolation of these small islands of endocrine cells from the sea of exocrine tissue that is the rest of the pancreas is not necessarily simple or quick. Choosing and administering the digestive enzyme, separation of the islets from acinar tissue, and culture of islets are all things that must be considered. The purpose of this review is

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"Arbutus Unedo Honey and Propolis Ameliorate Acute Kidney Injury, Acute Liver Injury, and Proteinuria via Hypoglycemic and Antioxidant Activity in Streptozotocin-Treated Rats." Cellular Physiology and Biochemistry 56, no. 1 (2022): 66–81. http://dx.doi.org/10.33594/000000496.

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BACKGROUND/AIMS: Honey and propolis have biological and therapeutic effects in various pathological and clinical conditions such as hyperglycemia and diabetes. However, the combined use of honey and propolis has not been reported. The study evaluated the protective effect of Arbutus unedo honey, propolis and their combination in streptozotocin (STR)-induced hyperglycemia, acute kidney injury (AKI), liver injury, dyslipidemia, and proteinuria in male Wistar rats. METHODS: The study identified physicochemical characteristics, mineral and antioxidant content, and antioxidant activity in honey and

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