Relevant bibliographies by topics / Islets of Langerhans Islets of Langerhans transplantation

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Academic literature on the topic 'Islets of Langerhans Islets of Langerhans transplantation'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Islets of Langerhans Islets of Langerhans transplantation"

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Lakey, Jonathan R. T., Garth L. Warnock, Ziliang Ao, and Ray V. Rajotte. "Bulk Cryopreservation of Isolated Islets of Langerhans." Cell Transplantation 5, no. 3 (1996): 395–404. http://dx.doi.org/10.1177/096368979600500306.

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Current methods to isolate human islets of Langerhans are limited and multiple donors are required for successful reversal of longstanding Type 1 diabetes mellitus. Cryopreservation of isolated islets is an effective method of storing and pooling islets. Current cryopreservation protocols are cumbersome due to current practices of placing small aliquots of islets per individual freezer tube. In the present study, we examined the application of a blood freezer bag for the cryopreservation of isolated islets by slow cooling and rapid thawing. Freezing and thawing profiles generated using thermoc
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Samejima, Tadashi, Kenji Yamaguchi, Hiroo Iwata, Noriyuki Morikawa, and Yoshito Ikada. "Gelatin Density Gradient for Isolation of Islets of Langerhans." Cell Transplantation 7, no. 1 (1998): 37–45. http://dx.doi.org/10.1177/096368979800700106.

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Isolation of islets of Langerhans (islets) has been performed by means of collagenase digestion of the pancreatic tissue combined with density gradient separation of islets from unwanted exocrine tissues. An enormous number of islets are necessary for clinical islet transplantation. The density gradient used for isolation of a large number of islets should satisfy several requirements in addition to those for the conventional density gradients, such as high viscosity for creating fine interfaces with a large area, easy sterilization, and low cost. This study is concerned with the development o
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Pakhomov, Oleg, Jiry Honiger, Edouard Gouin, Roland Cariolet, Gerard Reach та Sylviane Darquy. "Insulin Treatment of Mice Recipients Preserves β-Cell Function in Porcine Islet Transplantation". Cell Transplantation 11, № 7 (2002): 721–28. http://dx.doi.org/10.3727/000000002783985422.

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Encapsulation of islets of Langerhans confers protection against cell-mediated immune destruction and so should allow the transplantation of islets without immunosuppression. Xenotransplantation of encapsulated islets of Langerhans might therefore help overcome problems of human organ donor shortage. Given that islets exposed to sustained hyperglycemia show impaired β-cell function, we set out to determine whether recipient treatment with insulin could improve transplantation success rate. Islets of Langerhans were obtained from Specific Germ-Free (SPF) pig pancreas and cultured overnight. Isl
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Bucher, Mathe, Bosco, et al. "Islet of Langerhans Transplantation for the Treatment of Type 1 Diabetes." Swiss Surgery 9, no. 5 (2003): 242–46. http://dx.doi.org/10.1024/1023-9332.9.5.242.

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Islet of Langerhans transplantation is gaining recognition as a therapy for type 1 diabetes. The procedure involves enzymatic digestion of the pancreatic tissue, purification of the islets from the exocrine tissue, infusion of the islets into the portal vein and implantation in the liver. Until 1999, an overall rate of insulin independence of 14% at one year was reported in the International Islet Transplant Registry. The results of the "Edmonton protocol" since 2000 were a breakthrough in the field, with reports of 80% insulin independence at 1-year after solitary islet transplantation in non
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Gerő, László. "Őssejtterápia, β-sejt- és Langerhans-sziget-neogenezis: a jövő lehetséges terápiái 1-es típusú diabetesben?" Orvosi Hetilap 157, № 19 (2016): 740–45. http://dx.doi.org/10.1556/650.2016.30440.

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In type 1 diabetic patients perfect normoglycaemia can only be achieved by successful transplantation of the pancreas or Langerhans’ islets. Surgical transplantation of the whole pancreas is an invasive operation exerting great burden on the patients. Transplantation of the islets of Langerhans does not burden the patients but the survival of the islet grafts is limited. Both interventions are hampered by the lack of donor organs. However, much of these difficulties could be overcome by the use of “artificial β-cells” which ought to have an ultrastructure identical with that of natural β-cells
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Crowther, N. J., C. F. Gotfredsen, A. J. Moody, and I. C. Green. "Immunological and insulin secretory studies on isolated porcine islets of Langerhans." Journal of Endocrinology 126, no. 1 (1990): 43–49. http://dx.doi.org/10.1677/joe.0.1260043.

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ABSTRACT Since porcine islets are considered a likely tissue source for islet transplantation we have studied the insulin secretory responses to stimuli and some of the cell surface antigen characteristics of porcine islet cells. In a static incubation system, the threshold level of glucose required for the stimulation of insulin secretion from freshly isolated porcine islets was found to be between 2·8 and 4·2 mmol glucose/l. Arginine (5 mmol/l) and 3-isobutyl-1-methylxanthine (1 mmol/l) potentiated insulin release induced by 8·3 mmol glucose/l. Leucine (5 mmol/l) initiated release in the pre
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Portis, Andrew J., Ray V. Rajotte, and Teresa L. Krukoff. "Reinnervation of Isolated Islets of Langerhans Transplanted beneath the Kidney Capsule in the Rat." Cell Transplantation 3, no. 2 (1994): 163–70. http://dx.doi.org/10.1177/096368979400300204.

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Neural regulation of islets of Langerhans mediates responses to stress and food ingestion. Transplantation of isolated islets offers hope to patients with insulin dependent diabetes mellitus but denervation of isolated islets may affect the capacity for appropriate metabolic control. Previous examination of the endocrine response to stress in islet autografted dogs revealed differences consistent with loss of neural regulation. Therefore, in the present study, islets grafted in rats were examined for extent and nature of reinnervation. Islets isolated from syngeneic donors were grafted under t
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Nakagawara, Gizo. "Transplantation of islets of Langerhans." Journal of Hepato-Biliary-Pancreatic Surgery 1, no. 5 (1994): 542–45. http://dx.doi.org/10.1007/bf01211917.

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Van Der Burg, Michael P. M., Onno R. Guicherit, Marijke Frölich, Frans A. Prins, Jan Anthonie Bruijn, and Hein G. Gooszen. "Cell Preservation in University of Wisconsin Solution during Isolation of Canine Islets of Langerhans." Cell Transplantation 3, no. 4 (1994): 315–24. http://dx.doi.org/10.1177/096368979400300408.

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Allogeneic islet transplantation in Type I diabetic patients is considerably hampered by the variable outcome of islet isolation and purification. After collagenase digestion of the pancreas, islet isolation is traditionally performed under hypothermic conditions in physiological solutions such as Hanks and RPMI. The University of Wisconsin solution (UWS) has been shown superior for hypothermic preservation of the pancreas. We, therefore, compared the UWS and RPMI for canine islet isolation and subsequent purification in either a conventional hyperosmotic density gradient of dextran in Hanks,
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Chao, Seh-Huang, Madhusudan V. Peshwa, David E. R. Sutherland, and Wei-Shou Hu. "Entrapment of Cultured Pancreas Islets in Three-Dimensional Collagen Matrices." Cell Transplantation 1, no. 1 (1992): 51–60. http://dx.doi.org/10.1177/096368979200100109.

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In vitro culture of islets of Langerhans decreases their immunogenecity, presumably by eliminating passenger leukocytes and other Ia+ presenting cells within the islets. Islets cultivated in petri dishes either at 37°C or at 25°C gradually disintegrate during culture in a time-dependent manner which is related to the free-floating condition of the islets. Also, a fraction of the islets disperse as single cells and beta-cell aggregates or adhere to the bottom of the culture dishes. Thus, the retrieval rate of transplantable islets is dampened due to their disintegration and spontaneous dispersi
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Dissertations / Theses on the topic "Islets of Langerhans Islets of Langerhans transplantation"

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Ar'Rajab, Aamer. "Islet transplantation in the treatment of diabetes number of islets, functional regulation and metabolic control /." Lund : Dept. of Surgery, Lund University, 1991. http://catalog.hathitrust.org/api/volumes/oclc/38187937.html.

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Clayton, Heather Anne. "The encapsulation and transplantation of islets of Langerhans." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34306.

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Although several clinical human islet transplants have been performed, allograft rejection has been a major problem. Encapsulation in sodium alginate/poly-l-lysine has been proposed as a method to protect the islets from rejection and autoimmune destruction. The aims of this project were to determine optimum capsule composition and to assess encapsulated islet function following transplantation using the spontaneously diabetic BioBreeding (BB/d) rat as a model of autoimmune insulin-dependent diabetes. The membrane integrity of islets, determined by microfluorometry, was not adversely affected
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Koulmanda, Maria. "Transplantation of organ cultured foetal islets of Langerhans in mice." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29492.

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Foetal islets are functionally immature but retain their capacity for proliferation if harvested and cultured in an appropriate manner. Graft function was shown to depend largely on the gestational age and conditions of organ culture prior to transplantation. The required period of organ culture for optimal graft function was investigated for foetal mouse pancreas of different gestational ages. The growth of the graft in situ also depended on the diabetic state of the host, and chronic hyperglycaemia appeared to impair graft function. Subsequent studies using NOD recipient mice as a model for
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Coffey, Lane Claire Katherine. "Immune Cells, Inflammatory Molecules, and CD40 in Nonhuman Primate Islets of Langerhans." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/430.

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Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing beta cells in the pancreas. Amelioration of T1D and the prevention of its detrimental complications are possible through islet transplantation, wherein hormone-producing clusters of cells, islets of Langerhans (islets), are separated from the pancreas and transplanted into a diabetic patient. However, alterations due to the effects of organ recovery, cold ischemia time (CIT), and islet isolation may increase the inflammatory and immunogenic properties of these islets, thereby predisposing the
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King, Aileen. "Evaluation of Alginate Microcapsules for Use in Transplantation of Islets of Langerhans." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5113-6/.

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Cabrera, Over. "Autocrine/paracrine interactions modulating hormone release in the endocrine pancreas /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-378-8/.

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Mattsson, Göran. "Experimental studies on the vasculature of endogenous and transplanted islets of Langerhans /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3596.

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Bennet, William. "Isolated islets of Langerhans trigger an instant blood mediated inflammatory reaction : a finding with implications for intraportal islet transplantation /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4161-0/.

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Nyqvist, Daniel. "In vivo imaging of islet cells and islet revascularization /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-116-6/.

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Johansson, Åsa. "Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109713.

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Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. In the present thesis, isolated islet endothelial cells were found to have a low proliferatory and migratory capacity towards vascular endothelial growth factor (VEGF), but this could be reversed by using neutralizing antibodies to the angiostatic factors thrombo
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Books on the topic "Islets of Langerhans Islets of Langerhans transplantation"

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service), SpringerLink (Online, ed. The Islets of Langerhans. Springer Science+Business Media B.V., 2010.

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Islam, Md Shahidul, ed. The Islets of Langerhans. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3271-3.

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Islam, Md Shahidul, ed. Islets of Langerhans, 2. ed. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6884-0.

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Soria, Bernat, ed. Physiology and Pathophysiology of the Islets of Langerhans. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1819-2.

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Smith, Paul A. Electrophysiology of beta-cells from the Islets of Langerhans. University of EastAnglia, 1988.

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Kiranadi, Bambang. Electrophysiology of B-cells from the islets of Langerhans. University of East Anglia, 1990.

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Nikhilanandhan, Ganendra Srikrishn. Conformal coating of islets of Langerhans in HEMA-MMA. National Library of Canada, 1999.

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1942-, Brinn J. E., ed. The comparative physiology of the pancreatic islets. Springer-Verlag, 1987.

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Levesque, Lyne. Maintenance of secretory responses following microencapsulation of rat islets of langerhans. National Library of Canada, 1990.

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Pancreas, islet and stem cell transplantation for diabetes. 2nd ed. Oxford University Press, USA, 2010.

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Book chapters on the topic "Islets of Langerhans Islets of Langerhans transplantation"

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Cravedi, Paolo, Piero Ruggenenti, and Giuseppe Remuzzi. "Successes and Disappointments with Clinical Islet Transplantation." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_23.

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Cravedi, Paolo, Piero Ruggenenti, and Giuseppe Remuzzi. "Successes and Disappointments with Clinical Islet Transplantation." In Islets of Langerhans, 2. ed. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6884-0_23-1.

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Al-Abdullah, I. H., M. S. A. Kumar, M. S. Al-Adnani, and G. M. Abouna. "Does pretreatment of islets of Langerhans with deoxyguanosine improve allograft survival without immunosuppression?" In Organ Transplantation 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3386-9_54.

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Federlin, K., B. J. Hering, and R. G. Bretzel. "Transplantation of Isolated Islets of Langerhans as Treatment of Diabetes Mellitus." In Cellular Therapy. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-03509-2_6.

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Cohrs, Christian M., Chunguang Chen, and Stephan Speier. "Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0385-7_11.

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In’t Veld, Peter, and Silke Smeets. "Microscopic Anatomy of the Human Islet of Langerhans." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_1.

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Bertram, Richard, Arthur Sherman, and Leslie S. Satin. "Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_10.

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Kasai, Haruo, Hiroyasu Hatakeyama, Mitsuyo Ohno, and Noriko Takahashi. "Exocytosis in Islet β-Cells." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_11.

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Ahmed, Meftun. "Proteomics Proteomics and Islet Research." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_12.

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Habener, Joel F., and Zhengyu Liu. "Wnt Signaling in Pancreatic Islets." In Islets of Langerhans. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-6686-0_13.

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Conference papers on the topic "Islets of Langerhans Islets of Langerhans transplantation"

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Mendoza-Elias, Joshua E., José Oberholzer, and Yong Wang. "Microfluidics for Live-Cell Imaging Pancreatic Islets of Langerhans for Human Transplant." In ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting collocated with the ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/fedsm2014-21159.

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Since the introduction of the Edmonton Protocol in 2000, islet transplantation has been emerging as promising therapy for Type I diabetes mellitus (T1DM) and currently is the only therapy that can achieve glycemic control without the need for exogenous insulin. Transplanting islet cells has several advantages over transplanting a whole pancreas in that it involves only a minor surgical procedure with low morbidity and mortality, and at a significantly lower cost. However, an obstacle to realizing this goal is a lack of an islet potency index as required by the U.S. Food and Drug Administration
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Švihlík, Jan, Jan Kybic, and David Habart. "Automated separation of merged Langerhans islets." In SPIE Medical Imaging, edited by Martin A. Styner and Elsa D. Angelini. SPIE, 2016. http://dx.doi.org/10.1117/12.2216798.

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Švihlík, Jan, Jan Kybic, David Habart, et al. "Classification of microscopy images of Langerhans islets." In SPIE Medical Imaging, edited by Sebastien Ourselin and Martin A. Styner. SPIE, 2014. http://dx.doi.org/10.1117/12.2043621.

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Jansen, T., M. Buitinga, M. Boss, et al. "Assessment of intrahepatic islet of Langerhans transplantation with dynamic Ga-68-NODAGA-exendin PET imaging." In NuklearMedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1683646.

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South, Jack C. M., and William J. Gullick. "Abstract C48: The role of the neuregulins and their receptors in the islets of Langerhans." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c48.

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Schönecker, S., KH Boven, and U. Kraushaar. "Beta-Screen: Non-invasive and easy to use MEA-based parallelized screening system for intact islets of Langerhans." In Late breaking Abstracts – Diabetes Kongress 2018 – 53. Jahrestagung der DDG. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1657802.

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Nieto-Chaupis, Huber. "Frequency-Based Releasing of Insulin in the Langerhans Islets To Counteract the Beginning of the Type-2 Diabetes in Pre-diabetes Patients." In 2019 IEEE 9th Annual Computing and Communication Workshop and Conference (CCWC). IEEE, 2019. http://dx.doi.org/10.1109/ccwc.2019.8666461.

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Husen, Saikhu Akhmad, Salamun, Arif Nur Muhammad Ansori, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, and Dwi Winarni. "The Effect of Alpha-mangostin in Glucose Level, Cholesterol Level, and Diameter of the Islets of Langerhans of STZ-induced Diabetic Mice." In 2nd International Conference Postgraduate School. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0007547005610566.

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Apáthy, Á., and M. Bély. "AB0327 Clinical significance of hormone-related (ISOLATED) amyloidosis of the islets of langerhans – a postmortem clinicopathologic statistical study of 234 rheumatoid arthritis patients." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.1042.

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Jansen, T., M. Boss, M. Buitinga, et al. "Validation of exendin for beta cell imaging: ex vivo autoradiography of human pancreas demonstrates specific accumulation of radiolabeled exendin in islets of Langerhans." In NuklearMedizin 2021 – digital. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1726802.

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