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Dissertations / Theses on the topic 'Islets of Langerhans Islets of Langerhans transplantation'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Ar'Rajab, Aamer. "Islet transplantation in the treatment of diabetes number of islets, functional regulation and metabolic control /." Lund : Dept. of Surgery, Lund University, 1991. http://catalog.hathitrust.org/api/volumes/oclc/38187937.html.

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2

Clayton, Heather Anne. "The encapsulation and transplantation of islets of Langerhans." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34306.

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Although several clinical human islet transplants have been performed, allograft rejection has been a major problem. Encapsulation in sodium alginate/poly-l-lysine has been proposed as a method to protect the islets from rejection and autoimmune destruction. The aims of this project were to determine optimum capsule composition and to assess encapsulated islet function following transplantation using the spontaneously diabetic BioBreeding (BB/d) rat as a model of autoimmune insulin-dependent diabetes. The membrane integrity of islets, determined by microfluorometry, was not adversely affected

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3

Koulmanda, Maria. "Transplantation of organ cultured foetal islets of Langerhans in mice." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29492.

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Foetal islets are functionally immature but retain their capacity for proliferation if harvested and cultured in an appropriate manner. Graft function was shown to depend largely on the gestational age and conditions of organ culture prior to transplantation. The required period of organ culture for optimal graft function was investigated for foetal mouse pancreas of different gestational ages. The growth of the graft in situ also depended on the diabetic state of the host, and chronic hyperglycaemia appeared to impair graft function. Subsequent studies using NOD recipient mice as a model for

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4

Coffey, Lane Claire Katherine. "Immune Cells, Inflammatory Molecules, and CD40 in Nonhuman Primate Islets of Langerhans." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/430.

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Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing beta cells in the pancreas. Amelioration of T1D and the prevention of its detrimental complications are possible through islet transplantation, wherein hormone-producing clusters of cells, islets of Langerhans (islets), are separated from the pancreas and transplanted into a diabetic patient. However, alterations due to the effects of organ recovery, cold ischemia time (CIT), and islet isolation may increase the inflammatory and immunogenic properties of these islets, thereby predisposing the

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5

King, Aileen. "Evaluation of Alginate Microcapsules for Use in Transplantation of Islets of Langerhans." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5113-6/.

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6

Cabrera, Over. "Autocrine/paracrine interactions modulating hormone release in the endocrine pancreas /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-378-8/.

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7

Mattsson, Göran. "Experimental studies on the vasculature of endogenous and transplanted islets of Langerhans /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3596.

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8

Bennet, William. "Isolated islets of Langerhans trigger an instant blood mediated inflammatory reaction : a finding with implications for intraportal islet transplantation /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4161-0/.

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9

Nyqvist, Daniel. "In vivo imaging of islet cells and islet revascularization /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-116-6/.

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10

Johansson, Åsa. "Properties of Endothelium and its Importance in Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109713.

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Transplantation of insulin producing cells is currently the only cure for type 1 diabetes. However, even though the Edmonton protocol markedly increased the success rate of pancreatic islet transplantation, the long term insulin independence is still very poor. An adequate engraftment is critical for islet graft survival and function. In the present thesis, isolated islet endothelial cells were found to have a low proliferatory and migratory capacity towards vascular endothelial growth factor (VEGF), but this could be reversed by using neutralizing antibodies to the angiostatic factors thrombo

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11

Mattsson, Göran. "Experimental Studies on the Vasculature of Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3596.

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<p>The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply as well as dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation. Previous studies have reported signs of poor engraftment of transplanted islets, presumably due to impaired revascularization. The aims of this thesis were to investigate the revascularization process of transplanted islets and to examine the role of islet endothelial cells. In this context, the lectin Bandeiraea simplicifolia

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12

Eriksson, Olof. "Imaging Islets of Langerhans by Positron Emission Tomography : Quantification of Beta-Cell Mass in the Native Pancreas and the Islet Graft." Doctoral thesis, Uppsala universitet, Enheten för radiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136372.

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Type 1 and 2 Diabetes Mellitus are a growing health problem throughout the world. There is an increasing need for methodologies, which are both reliable and non-invasive to measure the amount of insulin-producing tissue (Beta-cell mass, or BCM), as well as rapidly quantify changes in the BCM due to the onset of disease, beta-cell replacement therapy, or other treatments. Positron Emission Tomography (PET) is a non-invasive, quantitative functional imaging technique which can be used to study dynamical or static processes inside the body. In this thesis, we present a study protocol for in vivo

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13

Grapensparr, Liza. "Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327314.

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Type 1 diabetes develops through the progressive destruction of the insulin-producing beta-cells. Regeneration or replacement of beta-cells is therefore needed to restore normal glucose homeostasis. Presently, normoglycemia can be achieved by the transplantation of whole pancreas or isolated islets of Langerhans. Islet transplantation can be performed through a simple laparoscopic procedure, but the long-term graft survival is low due to poor revascularization and early cell death. This thesis examined the possibility of using different auxiliary cells (Schwann cells, endothelial progenitor ce

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14

Olsson, Richard. "The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7107.

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15

Christoffersson, Gustaf. "Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196486.

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Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. Understanding the mechanisms behind blood vessel growth generates increased means to control angiogenesis. In this thesis a model of pancreatic islet transplantation to muscle has been used to study the involvement of leukocytes in the development of new vasculature. Transplantation of isolated islets of Langerhans into m

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16

Cabric, Sanja. "Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8333.

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<p>During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. </p><p>The islets are infused into the liver via the portal vein, and once exposed to the blood, the grafted tissue has been shown to be damaged by the instant blood-mediated inflammatory reaction (IBMIR), which is characterized by coagulation and complement activation as well as leukocyte infiltration int

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17

Phelps, Edward Allen. "Bio-functionalized peg-maleimide hydrogel for vascularization of transplanted pancreatic islets." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45899.

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Type 1 diabetes affects one in every 400-600 children and adolescents in the US. Standard therapy with exogenous insulin is burdensome, associated with a significant risk of dangerous hypoglycemia, and only partially efficacious in preventing the long term complications of diabetes. Pancreatic islet transplantation has emerged as a promising therapy for type 1 diabetes. However, this cell-based therapy is significantly limited by inadequate islet supply (more than one donor pancreas is needed per recipient), instant blood-mediated inflammatory reaction, and loss of islet viability/function dur

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18

Hårdstedt, Maria. "Studies of Innate and Adaptive Immunity in Islet Transplantation." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232863.

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Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. Obstacles to advancing islet transplantation include limited engraftment resulting from an immediate blood-mediated inflammatory reaction (IBMIR), a life-long need for immunosuppression and the shortage of organs available. In this thesis, innate and adaptive immunity were explored in allogeneic and xenogeneic settings, with the long-term goal of preventing islet graft

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19

Beilke, Joshua Nathan. "NK cell involvement in the induction of allograft tolerance /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Immunology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 133-151). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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20

Moberg, Lisa. "The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4260.

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21

Lindeborg, Ellinor. "Immunity against porcine islet xenografts in man /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-628-6657-5/.

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22

Johansson, Helena. "Mechanisms and Therapeutic Interventions of Instant Blood-Mediated Inflammatory Reaction (IBMIR)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7786.

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23

Vaissié, Alix. "Alternatives to “native human islets” for research in vitro and in vivo : pseudo-islets and pancreatic endocrine cells from pluripotent stem cells – the role of progerin in differentiation and maturation." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S035.

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Introduction : L'utilisation des îlots humains de Langerhans est la référence pour la recherche, tant physiologique que pour le développement de nouvelles molécules thérapeutiques pour le traitement du diabète de type 2. La demande d'îlots de Langerhans humains pour des projets de recherche est en constante augmentation, cependant, la disponibilité est limitée et les différentes préparations d'îlots de Langerhans révèlent une grande variabilité entre elles.Objectifs : L'objectif principal de cette thèse était de proposer une alternative aux îlots de Langerhans humains natifs qui permettrait d’

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24

Lau, Joey. "Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8418.

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25

Sleater, Michelle Leigh. "Cellular and molecular effector mechanisms of islet allograft rejection /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Immunology) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 151-168). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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26

Scott, Ryan 1981. "Investigating the natural history of human islet-derived duct-like structures transplanted subcutaneously into nude mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112362.

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Islet plasticity has proven to be an important platform for the engineering of alternative islet tissue for transplantation. In vitro studies have shown the ability of islets to transdifferentiate into duct-like epithelial structures (DLS) thought to possess progenitor cells capable of replenishing damaged tissue within the pancreas. The aim of this study was to investigate the natural history of human derived duct-like epithelial structures transplanted into nude mice.<br>Human islet derived duct-like structures from three cadaver pancreases were subcutaneously transplanted into 6-8 week old

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27

Schmidt, Peter. "Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3942.

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28

Vågesjö, Evelina. "Exploring immune cell functions and ways to make use of them." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299683.

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In addition to host defense, alternative functions of immune cells are emerging. Immune cells are crucial during healing of injured tissue, in formation of new blood vessels, angiogenesis, and also in maintaining the balance in inflammation having immune regulating functions. Over the last decade a higher degree of heterogeneity and plasticity of immune cells have been reported and immune cells develop different characteristics in different situations in vivo. This thesis investigates roles for immune cells in situations of muscle hypoxia and reduced blood perfusion, wound healing in skin and

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29

Gargani, Sofia. "Adaptive changes of human islets to an obesogenic environment in the mouse." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S018/document.

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Dans les conditions normales, les organismes maintiennent une masse cellulaire endocrine stable tout au long de leur vie. En cas d’obésité, la masse de cellules b pancréatiques est capable de maintenir des taux de glucose plasmatique en augmentant la sécrétion en insuline. L’incapacité de ces cellules à fournir de l’insuline entraîne alors l’apparition d’une hyperglycémie et d’un diabète de type II. Cliniquement, la majorité des individus obèses ne développent pas de diabète car les îlots pallient à cette résistance à l’insuline. La preuve de l’adaptation de la masse d’îlots humains à l’obésit

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30

Giraud, Sébastien. "Stratégies de préservation et d'immunoprotection du greffon dans un modèle de transplantation d'îlots pancréatiques." Thesis, Poitiers, 2013. http://www.theses.fr/2013POIT1405/document.

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Actuellement les transplanteurs sont confrontés à une pénurie de greffons, conduisant à l'élargissement des critères de choix des donneurs. Cette démographie fait place à des greffons plus sensibles aux lésions d'ischémie-reperfusion (I/R). Ces lésions conduisent à des dysfonctions de reprises de fonction des greffons, et participent à l'augmentation de l'immunogénicité du greffon et à l'emergence de rejets aigus et chroniques. Dans un premier temps, il est donc nécessaire de limiter les lésions d'I/R et conserver l'intégrité du greffon. Dans un deuxième temps, il est important de réduire l'im

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31

Nguidjoe, Evrard. "Etude de la fonction de la cellule bêta pancréatique dans un modèle de souris présentant une mutation nulle partielle de l'échangeur sodium/calcium." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209833.

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Précédemment, nous avons montré que la surexpression de l'échangeur Na/Ca NCX1), une protéine responsable de la sortie de calcium (Ca2+) des cellules, augmentait la mort cellulaire programmée ou « apoptose » et réduisait la prolifération des cellules β. Afin d’étudier plus en profondeur le rôle de l’échangeur dans les cellules β in vivo, nous avons développé et caractérisé des souris présentant une inactivation de NCX1.<p>Des méthodes biologiques et morphologiques (imagerie du Ca2+, capture de Ca2+, métabolisme du glucose, sécrétion d'insuline et morphométrie par comptage de points) ont été ut

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32

Oliveira, Elizabeth Maria Costa de. "Avaliação funcional, in vitro e in vivo, de ilhotas pancreáticas humanas nuas e microencapsuladas." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-22012015-165806/.

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Diabetes mellitus tipo 1 resulta da produção insuficiente ou da ausência de insulina, decorrente da destruição de células β, por mecanismo auto-imune. O tratamento deste tipo de diabetes consiste na administração subcutânea de insulina exógena. Recentemente, foi demonstrado que o transplante de ilhotas pancreáticas é capaz de tornar o portador de diabetes tipo 1 independente de insulina exógena. Apesar do sucesso alcançado, a necessidade permanente de imunossupressão é uma das principais barreiras para que o transplante de ilhotas possa ser realizado em número maior de pacientes. Assim, o

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33

Lambert, Julie. "Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/344.

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NOD mice model human type 1 diabetes and have been used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. Costimulation blockade-based tolerance protocols that induce prolonged skin and permanent islet allograft survival in non-autoimmune mice have failed in NOD mice. To investigate the underlying mechanisms, we generated NOD hematopoietic chimeras. We were able to show that dendritic cell maturation defects seen in NOD mice are partially corrected in mixed hematopoietic chimeras. Furthermore, skin allograft survival was dependent upon the phe

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34

Dellê, Humberto. "Indução da expressão da molécula indoleamina 2,3-dioxigenase (IDO) como terapia gênica em transplante experimental de ilhotas pancreáticas." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-11092007-133551/.

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O transplante (Tx) de ilhotas pancreáticas (IP) é uma atraente alternativa para o tratamento do diabetes melito tipo 1. No entanto, para evitar a rejeição há necessidade de imunossupressão. Uma nova idéia de tolerância surge a partir do paradoxo imunológico, onde a mãe, imunologicamente competente, não rejeita o embrião durante a gravidez. Uma das hipóteses é que células da placenta expressam a molécula IDO, a qual protege o embrião do ataque imunológico materno. O objetivo do estudo foi analisar o efeito da indução da expressão da IDO em IP em transplante experimental de IP. Para tanto, as se

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35

Campos-Lisbôa, Ana Carolina Vale. "Ilhotas pancreáticas humanas viáveis para o transplante através do aumento da massa de células e do imunoisolamento com microcápsulas biocompatíveis." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-17062009-110527/.

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O transplante de ilhotas pancreáticas humanas representa uma estratégia promissora para a cura do diabetes mellitus tipo 1 (DM1), mas a aplicação a todos os pacientes diabéticos ainda é impraticável devido à limitada disponibilidade de ilhotas ou células β e à necessidade de utilização de drogas imunossupressoras pelo paciente transplantado. O tratamento com imunossupressores após o transplante de ilhotas pode ser abolido quando se realiza o microencapsulamento das ilhotas pancreáticas. Neste trabalho investigou-se um novo biomaterial, Biodritina® (alginato/sulfato de condroitina) adequad

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36

Westerlund, Johanna. "Pulsatile insulin release from single islets of Langerhans." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-494.

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<p>Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. Diabetic patients show an abnormal plasma insulin pattern, but the cause of the disturbance remains to be elucidated. Ithe present thesis the influence of the cytoplasmic calcium concentratio([Ca<sup>2+</sup>]<sub>i</sub>) and cell metabolism on pulsatile insulin release was examined in single islets of Langerhans from <i>ob/ob</i>-mi

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37

Pearson, Todd. "The Genetic Basis of Resistance to Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/16.

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The NOD mouse is a widely studied model of type 1 diabetes. The loss of self-tolerance leading to autoimmune diabetes in NOD mice involves at least 27 genetic loci. Curing type I diabetes in mice and humans by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction would be preferable. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation blockade using donor-specific transfusion and anti-CDl54 antibody.

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38

Nikhilanandhan, Ganendra S. "Conformal coating of islets of Langerhans in HEMA-MMA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0001/MQ45898.pdf.

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39

Smith, P. A. "Electrophysiology of #beta#-cells form the islets of Langerhans." Thesis, University of East Anglia, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380117.

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40

Shenkman, Rustin M. "Quadrupole Magnetic Sorting (QMS) of Porcine Islets of Langerhans." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229640573.

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41

LUAN, NGUYEN MINH. "PROTECTION OF ISLETS OF LANGERHANS FROM COMPLEMENT MEDIATED CYTOTOXICITY." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/151986.

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42

Alves, Figueiredo Hugo Jorge. "Improving islet-graft revascularization." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586309.

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El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de islotes donantes así como el uso de regímenes de inmunosupresores libres de esteroides. Además es un procedimiento quirúrgico menos invasivo y que conlleva menos complicaciones comparado con el trasplante de páncreas. A pesar de los importantes avances establecidos por el protocolo de Edmonton, el uso clínico del trasplante de islotes para el tratamiento de pacientes DT1 cont

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43

Moëll, Annika. "Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8501.

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<p>Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. Induction of such genes has previously been shown in EV-infected islets <i>in vitro</i>. Modulation of inflammatory mediators expressed in the islets could be a possible strategy to reduce β-cell destruction.</p><p>In the first paper we screened uni

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44

Paraskevas, Steven. "Pathways signaling apoptosis and survival in isolated islets of Langerhans." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84306.

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The transplantation of islets of Langerhans is a promising procedure which could, if successful, restore normal glucose homeostasis in a recipient with type 1 diabetes, while avoiding the risks associated with whole organ pancreas transplantation.<br>The studies presented here observed the cellular and subcellular response to the process of islet isolation. The first paper made the primary observation of apoptosis after isolation, as manifested by the appearance of apoptotic bodies, DNA fragmentation, and the activation of the enzyme tissue transglutaminase. Importantly, the fact that c

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Moëll, Annika. "Inflammatory mediators and enterovirus infections in human islets of Langerhans /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8501.

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46

Lundén, Mattias. "Mathematical modeling of insulin response in encapsulated islets of Langerhans." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231163.

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Transplantation of the islets of Langerhans is a promising technique for restoring the impairedinsulin production in brittle type 1 diabetics. The downside is that the patient will have to takeimmunosuppressant drugs in order to protect the islet cells from the immune system. Donorsare also sparse, making the quest of finding sufficient amounts of islets for transplantationhard. Encapsulation of the islets of Langerhans has been proposed as a means of protectingthe cells from the immune system taking away the need for immunosuppresives. The mostcommon encapsulation technique is extravascular c

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Hadjivassiliou, Vicky. "Cytokine inhibitory actions and gene expression in islets of Langerhans." Thesis, University of Sussex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311334.

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Marshall, Jonathon J. A. "Regulation of insulin gene expression in rat islets of Langerhans." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/35103.

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The rate of glucose stimulated in vitro (pro)insulin synthesis in islets of Langerhans isolated from fed male rats was determined. Increases in the glucose concentration of the incubation medium, over the physiological range (2 to 20 mM), stimulated the rates of both (pro)insulin and total protein synthesis during a two hour incubation. This stimulation was preferential for (pro)insulin synthesis and had a sigmoidal dose response curve with a concentration threshold of between 2.5 mM and 5.0 mM and a maximal rate at 20 mM glucose. Inhibition of islet RNA synthesis by.;ctinomycin D depressedthe

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Sandberg, Monica. "Intracellular Degradation of Insulin in Pancreatic Islets." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7586.

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Axcrona, Ulrika Myrsén. "Expression and regulation of neuropeptide Y (NPY) in the Islets of Langerhans." Lund : Dept. of Physiology and Neuroscience, Section for Neuroendocrine Cellbiology, Lund University, 1997. http://books.google.com/books?id=Ew5rAAAAMAAJ.

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